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https://www.readbyqxmd.com/read/29353407/role-of-the-petrous-ridge-and-angulation-of-the-trigeminal-nerve-in-the-pathogenesis-of-trigeminal-neuralgia-with-implications-for-microvascular-decompression
#1
Andrei Brinzeu, Chloé Dumot, Marc Sindou
INTRODUCTION: Vascular compression is the main pathogenetic factor in apparently primary trigeminal neuralgia; however some patients may present with clinically classical neuralgia but no vascular conflict on MRI or even at surgery. Several factors have been cited as alternative or supplementary factors that may cause neuralgia. This work focuses on the shape of the petrous ridge at the point of exit from the cavum trigeminus as well as the angulation of the nerve at this point. METHODS: Patients with trigeminal neuralgia that had performed a complete imagery workup according to our protocol and had microvascular decompression were included as well as ten controls...
January 20, 2018: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29353381/effect-of-kaempferol-pretreatment-on-myocardial-injury-in-rats
#2
Anamika Vishwakarma, Thakur Uttam Singh, Soya Rungsung, Tarun Kumar, Arunvikram Kandasamy, Subhashree Parida, Madhu Cholenahalli Lingaraju, Ajay Kumar, Asok Kumar, Dinesh Kumar
The present study was undertaken to evaluate the effect of kaempferol in isoprenaline (ISP)-induced myocardial injury in rats. ISP was administered subcutaneously for two subsequent days to induce myocardial injury. Assessment of myocardial injury was done by estimation of hemodynamic functions, myocardial infarcted area, cardiac injury markers, lipid profile, oxidative stress, pro-inflammatory cytokines and histopathology of heart and liver. Rats pretreated with kaempferol showed reduction in the myocardial infarcted area and heart rate...
January 20, 2018: Cardiovascular Toxicology
https://www.readbyqxmd.com/read/29353319/management-strategies-for-noncardiac-surgery-following-a-coronary-artery-event
#3
REVIEW
Thomas F Whayne, Sibu P Saha
PURPOSE OF REVIEW: Coronary artery event includes acute coronary syndrome (ACS), percutaneous coronary intervention (PCI), and coronary artery bypass graft (CABG) surgery. Following such an event, risk of noncardiac surgery is increased. Of major concern is what can make this surgery safer? RECENT FINDINGS: High functional capacity improves cardiovascular (CV) risk; at least 4.0 metabolic equivalents (METs) on stress test are favorable. Risk scores can suggest need for further evaluation...
January 20, 2018: Current Cardiology Reports
https://www.readbyqxmd.com/read/29353281/the-effectiveness-of-dietary-approaches-to-stop-hypertension-diet-intervention-in-persons-with-arterial-hypertension-and-obesity-a-key-role-of-the-patients-personality-profile
#4
Alicja Kucharska, Mariusz Jaworski, Mariusz Panczyk, Magdalena Pilska, Danuta Gajewska, Joanna Niegowska
BACKGROUND/AIMS: Benefits resulting from weight loss and dietary approaches to stop hypertension (DASH) diet in the treatment of arterial hypertension led to a search for a better therapy that would include psychological factors. The present study aimed to assess the relationship between the personality traits included in the Big Five personality traits and the effectiveness of treatment for weight loss in patients with essential hypertension and excessive body weight. METHODS: The study involved 84 patients with essential hypertension, overweight or obesity, managed by a hypertensiologist...
January 19, 2018: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/29353224/coronary-microvascular-dysfunction-may-be-related-to-igf-1-in-acromegalic-patients-and-can-be-restored-by-therapy
#5
Sara Tellatin, Pietro Maffei, Elena Osto, Francesca Dassie, Giulia Famoso, Roberta Montisci, Chiara Martini, Francesco Fallo, Martina Perazzolo Marra, Roberto Mioni, Sabino Iliceto, Roberto Vettor, Francesco Tona
BACKGROUND AND AIMS: Acromegaly increases the risk of cardiovascular mortality. Data on the cardiovascular risk in asymptomatic acromegaly are limited. In particular, data on coronary microvascular abnormalities are lacking. We assessed coronary flow reserve (CFR) as a marker of coronary microvascular function in asymptomatic acromegaly. METHODS: We studied 40 acromegalic patients (23 male, age 52 ± 11 years) without clinical evidence of cardiovascular disease, and 40 control subjects matched for age and sex...
December 24, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29353219/blocking-mitochondrial-cyclophilin-d-ameliorates-tsh-impaired-defensive-barrier-of-artery
#6
Xiaojing Liu, Heng Du, Qiang Chai, Qing Jia, Lu Liu, Meng Zhao, Jun Li, Hui Tang, Wenbin Chen, Lifang Zhao, Li Fang, Ling Gao, Jiajun Zhao
AIMS: Endothelial cells (ECs) constitute the defensive barrier of vasculature, which maintains the vascular homeostasis. Mitochondrial oxidative stress (mitoOS) in ECs significantly affects the initiation and progression of vascular diseases. The higher serum thyroid stimulating hormone (TSH) level is being recognized as a nonconventional risk factor responsible for the increased risk of cardiovascular diseases in subclinical hypothyroidism (SCH). However, effects and underlying mechanisms of elevated TSH on ECs are still ambiguous...
January 9, 2018: Redox Biology
https://www.readbyqxmd.com/read/29353133/maternal-serum-uric-acid-levels-and-blood-pressure-during-pregnancy-a-community-based-cohort-study
#7
Guoli Zhou, Claudia Holzman, Zhehui Luo, Claire Margerison
OBJECTIVE: Studies find both very low and high serum uric acid (UA) levels are related to oxidative stress and to conditions such as cardiovascular diseases and chronic kidney disease in the general population. Pregnancy studies have focused only on high maternal UA. In present study, we tested whether unusually high and low levels of maternal serum UA are associated with increases in blood pressure (BP) during pregnancy. STUDY DESIGN: The Pregnancy Outcomes and Community Health Study enrolled 3019 pregnant women between their 16th-27th week of pregnancy from 52 clinics in 5 Michigan communities (1998-2004)...
January 9, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29353043/progression-of-vasogenic-edema-induced-by-activated-microglia-under-permanent-middle-cerebral-artery-occlusion
#8
Miki Tanaka, Yasuhiro Ishihara, Shodo Mizuno, Atsuhiko Ishida, Christoph F Vogel, Mayumi Tsuji, Takeshi Yamazaki, Kouichi Itoh
Brain edema is a severe complication that accompanies ischemic stroke. Increasing evidence shows that inflammatory cytokines impair tight junctions of the blood-brain barrier, suggesting the involvement of microglia in brain edema. In this study, we examined the role of microglia in the progression of ischemic brain edema using mice with permanent middle cerebral artery occlusion. The intensity of T2-weighted imaging (T2WI) in the cerebral cortex and the striatum was elevated 3 h after occlusion and spread to peripheral regions of the ischemic hemisphere...
January 15, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29352997/microglia-and-neonatal-brain-injury
#9
Carina Mallard, Marie-Eve Tremblay, Zinaida S Vexler
Microglial cells are now recognized as the "gate-keepers" of healthy brain microenvironment with their disrupted functions adversely affecting neurovascular integrity, neuronal homeostasis, and network connectivity. The perception that these cells are purely toxic under neurodegenerative conditions has been challenged by a continuously-increasing understanding of their complexity, the existence of a broad array of microglial phenotypes, and their ability to rapidly change in a context-dependent manner to attenuate or exacerbate injuries of different nature...
January 15, 2018: Neuroscience
https://www.readbyqxmd.com/read/29352881/carbon-nanotube-modified-oxidized-regenerated-cellulose-gauzes-for-hemostatic-applications
#10
Feng Cheng, Changyu Liu, Hongbin Li, Xinjing Wei, Tingsheng Yan, Yunfeng Wang, Yunjia Song, Jinmei He, Yudong Huang
Functionalized carbon nanotubes have recently received interest because of their unique properties, especially in the biomedical field. In this research, unmodified multiwalled carbon nanotubes (MWCNTs), and functionalized carbon nanotubes with amino groups (MWCNTs-NH2) and carboxyl groups (MWCNTs-COOH) were grafted to oxidized regenerated cellulose (ORC) gauze to fabricate novel functionalized ORC, and the performance of the functionalized gauze was investigated. The functionalized ORC was characterized by FT-IR, XPS and SEM, which showed the different kinds of CNTs grafted on its surface...
March 1, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29352859/is-selective-5-ht1f-receptor-agonism-an-entity-apart-from-that-of-the-triptans-in-antimigraine-therapy
#11
REVIEW
Eloísa Rubio-Beltrán, Alejandro Labastida-Ramírez, Carlos M Villalón, Antoinette MaassenVanDenBrink
Migraine is a neurovascular disorder that involves activation of the trigeminovascular system and cranial vasodilation mediated by release of calcitonin gene-related peptide (CGRP). The gold standard for acute migraine treatment are the triptans, 5-HT1B/1D/(1F) receptor agonists. Their actions are thought to be mediated through activation of: (i) 5-HT1B receptors in cranial blood vessels with subsequent cranial vasoconstriction; (ii) prejunctional 5-HT1D receptors on trigeminal fibers that inhibit trigeminal CGRP release; and (iii) 5-HT1B/1D/1F receptors in central nervous system involved in (anti)nociceptive modulation...
January 17, 2018: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29352850/ultrasound-to-detect-involvement-of-vertebral-artery-in-giant-cell-arteritis
#12
Martin Gehlen, Nikolaus Schaefer, Michael Schwarz-Eywill, A Maier
No abstract text is available yet for this article.
January 11, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29352769/resolvin-e1-resolvin-d1-and-resolvin-d2-inhibit-constriction-of-rat-thoracic-aorta-and-human-pulmonary-artery-induced-by-the-thromboxane-mimetic-u46619
#13
Melanie Jannaway, Christopher Torrens, Jane A Warner, Anthony P Sampson
BACKGROUND AND PURPOSE: Omega-6 fatty acid-derived lipid mediators such as prostanoids, thromboxane and leukotrienes have well-established roles in regulating both inflammation and smooth muscle contractility. Resolvins are derived from omega-3 fatty acids and have important roles in promoting the resolution of inflammation, but their activity on smooth muscle contractility is unknown. We investigated whether resolvin E1 (RvE1), resolvin D1 (RvD1) and resolvin D2 (RvD2) can modulate contractions of isolated segments of rat thoracic aorta (RTA) or human pulmonary artery (HPA) induced by the α1 -adrenoceptor agonist phenylephrine or the stable thromboxane A2 mimetic U46619...
January 20, 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29352760/endothelial-function-estimated-by-digital-reactive-hyperemia-in-patients-with-atherosclerotic-risk-factors-or-coronary-artery-disease
#14
Jeehoon Kang, Hack-Lyoung Kim, Jae-Bin Seo, Jin-Yong Lee, Min-Kyong Moon, Woo-Young Chung
Due to the complex profile of atherosclerotic risk factors, an integrated analysis of a specific individual is difficult. Endothelial function reflects a composite of various risk factors, and may be used as an optimal tool to estimate the overall atherosclerotic risk. In this study, we investigated the value of digital Reactive Hyperemia Index (RHI) in an actual population with multiple atherosclerotic risk factors or coronary artery disease (CAD). A total of 417 patients from the Seoul National University Boramae Medical Center RHI registry were enrolled in this study...
January 19, 2018: Heart and Vessels
https://www.readbyqxmd.com/read/29352759/regional-myocardial-function-abnormalities-are-associated-with-macro-and-microcirculation-dysfunction-in-the-metabolic-syndrome-the-resolve-study
#15
Philippe Obert, Guillaume Walther, Frédéric Dutheil, Bruno Lesourd, Robert Chapier, Daniel Courteix, Agnes Vinet
Abnormalities in myocardial and vascular function have been reported in the metabolic syndrome (MetS), but whether these alterations are related remains poorly documented. Our aim was accordingly to investigate interrelationships between macro- and microcirculatory vasoreactivity and left ventricular (LV) myocardial function in MetS patients. Eighty-eight MetS individuals and 44 age- and gender-matched healthy controls were enrolled. LV global longitudinal strain (GLS) was measured using Vector Velocity Imaging...
January 19, 2018: Heart and Vessels
https://www.readbyqxmd.com/read/29352696/safety-and-efficacy-of-prostatic-artery-chemoembolization-for-prostate-cancer-initial-experience
#16
João Pisco, Tiago Bilhim, Nuno V Costa, Manuel Pinto Ribeiro, Lucia Fernandes, António G Oliveira
PURPOSE: To evaluate outcome of prostatic artery chemoembolization for patients with prostate cancer (PCa). MATERIALS AND METHODS: This single-center prospective cohort study was conducted between August 2013 and July 2016 in 20 patients with PCa who underwent chemoembolization. Mean patient age was 67.5 years ± 6.4. Gleason score was 6-10, and staging was T2N0M0. Fifteen patients refused prostatectomy and 5 wanted to stop hormonal therapy because of side effects...
January 15, 2018: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/29352676/cardiorespiratory-dynamics-of-rescuers-during-cardiopulmonary-resuscitation-in-a-hypoxic-environment
#17
Tomonobu Sato, Tomonori Takazawa, Masahiro Inoue, Yasunori Tada, Takashi Suto, Masaru Tobe, Shigeru Saito
OBJECTIVE: We had previously experienced a case involving prolonged cardiopulmonary resuscitation (CPR) on Mt. Fuji (3776 m), demanding strenuous work by the rescuers. The objective of this study was to compare the effect of compression-only and conventional CPR on oxygen saturation of rescuers in a hypoxemic environment. METHODS: Changes in percutaneous arterial oxygen saturation (SpO2) and heart rate during CPR action were measured in a hypobaric chamber with barometric pressure adjusted to be equivalent to 3700 m above sea level (630-640 hPa)...
January 8, 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29352673/chest-pain-in-a-young-female
#18
Paul S Basel, Daniel Reschke, Michael D April
Acute Coronary Syndrome (ACS) is a common diagnosis in the emergency department (ED), the most severe manifestation of which is ST elevation on electrocardiogram (ECG). ST elevation reflects obstruction of flow through the coronary arteries, most commonly due to coronary atherosclerotic plaque rupture. However, alternative causes of coronary obstruction causing ST elevation are possible. Spontaneous coronary artery dissection (SCAD) is an unusual cause of ST elevation in ED patients which providers may encounter in patients without traditional atherosclerosis risk factors...
January 11, 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29352651/catheter-injected-bone-marrow-mesenchymal-stem-cells-induce-efficacious-occlusion-of-arteriovenous-nidus-in-a-swine-model
#19
Joseph Touma, Jianping Dai, Andre Gaston, Marianne Gervais, Eric Allaire
OBJECTIVES: Arteriovenous malformations (AVMs) are complex vascular lesions. Surgical excision is the treatment of choice, but is often not achievable. Embolo-sclerotherapy alone is associated with high recurrence rates. This study tested the hypothesis that seeding hydrogel conditioned bone marrow derived mesenchymatous stem cells (BM-MSCs) in an AVM nidus model induces solid microvascular occlusion through endoluminal tissue growth. METHODS: AVMs were modelled as arteriovenous microvascular nidus, using swine rete mirabile, a plexiform intracranial structure composed of arterial microvessels that extensively anastomose...
January 15, 2018: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/29352594/systematic-review-of-uterine-artery-embolisation-practice-guidelines-are-all-the-guidelines-on-the-same-page
#20
H T Chen, S Athreya
AIM: To evaluate the degree of concordance amongst the currently available guidelines informing the use of uterine artery embolisation (UAE), and identify any inconsistencies present. MATERIALS AND METHODS: Standards of practice and quality improvement guidelines were retrieved through a search of PubMed and EMBASE. Additional sets of guidelines were retrieved directly from the websites of known obstetrics and gynaecology and radiological associations. RESULTS: Eleven guidelines were retrieved from organisations located in Europe, North America, and Australia...
January 15, 2018: Clinical Radiology
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