keyword
MENU ▼
Read by QxMD icon Read
search

MDD

keyword
https://www.readbyqxmd.com/read/28749091/efficacy-of-ziprasidone-augmentation-of-escitalopram-for-cognitive-symptoms-of-major-depressive-disorder
#1
Nadia Iovieno, Richard C Shelton, Samuel R Petrie, Cristina Cusin, Maurizio Fava, George I Papakostas
OBJECTIVE: To examine the efficacy of adjunctive ziprasidone for cognitive symptoms in adult patients with major depressive disorder (MDD) experiencing persistent symptoms after 8 weeks of open-label escitalopram. METHODS: This post hoc analysis was conducted on a database derived from a previously published study. The parent study was a multicenter, parallel, randomized, double-blind, placebo-controlled trial conducted at 3 academic medical centers in the United States from July 2008 to October 2013...
July 25, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28749090/relationships-of-cerebrospinal-fluid-monoamine-metabolite-levels-with-clinical-variables-in-major-depressive-disorder
#2
Hyung Shin Yoon, Kotaro Hattori, Shintaro Ogawa, Daimei Sasayama, Miho Ota, Toshiya Teraishi, Hiroshi Kunugi
OBJECTIVE: Many studies have investigated cerebrospinal fluid (CSF) monoamine metabolite levels in depressive disorders. However, their clinical significance is still unclear. We tried to determine whether CSF monoamine metabolite levels could be a state-dependent marker for major depressive disorder (MDD) based on analyses stratified by clinical variables in a relatively large sample. METHODS: Subjects were 75 patients with MDD according to DSM-IV criteria and 87 healthy controls, matched for age, sex, and ethnicity (Japanese)...
July 25, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28749089/cognitive-deficits-in-patients-with-neuropsychiatric-symptoms-a-comparative-study-between-behavioral-variant-frontotemporal-dementia-and-primary-psychiatric-disorders
#3
Everard G B Vijverberg, Sigfried Schouws, Paul David Meesters, Esmée Verwijk, Hannie Comijs, Ted Koene, Charlotte Schreuder, Aartjan Beekman, Philip Scheltens, Max Stek, Yolande Pijnenburg, Annemieke Dols
OBJECTIVE: To compare neuropsychological profiles in behavioral variant frontotemporal dementia (bvFTD) with its most common primary psychiatric differential diagnoses, major depressive disorder (MDD), bipolar disorder (BD), and schizophrenia, in older patients with active symptoms. METHODS: We included patients from different cohorts with MDD (DSM-IV-TR: 296.20-296.23, 296.30-296.33; n = 42; mean ± SD age, 72.0 ± 8.0 years; female = 57.1%) included from 2002 to 2007, noneuthymic BD (DSM-IV-TR: 296...
July 25, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28748306/low-emotion-oriented-coping-and-informal-help-seeking-behaviour-as-major-predictive-factors-for-improvement-in-major-depression-at-5-year-follow-up-in-the-adult-community
#4
S Rodgers, C L Vandeleur, M-P F Strippoli, E Castelao, A Tesic, J Glaus, A M Lasserre, M Müller, W Rössler, V Ajdacic-Gross, M Preisig
PURPOSE: Given the broad range of biopsychosocial difficulties resulting from major depressive disorder (MDD), reliable evidence for predictors of improved mental health is essential, particularly from unbiased prospective community samples. Consequently, a broad spectrum of potential clinical and non-clinical predictors of improved mental health, defined as an absence of current major depressive episode (MDE) at follow-up, were examined over a 5-year period in an adult community sample...
July 26, 2017: Social Psychiatry and Psychiatric Epidemiology
https://www.readbyqxmd.com/read/28744228/adolescent-major-depressive-disorder-neuroimaging-evidence-of-sex-difference-during-an-affective-go-no-go-task
#5
Jie-Yu Chuang, Cindy C Hagan, Graham K Murray, Julia M E Graham, Cinly Ooi, Roger Tait, Rosemary J Holt, Rebecca Elliott, Adrienne O van Nieuwenhuizen, Edward T Bullmore, Belinda R Lennox, Barbara J Sahakian, Ian M Goodyer, John Suckling
Compared to female major depressive disorder (MDD), male MDD often receives less attention. However, research is warranted since there are significant sex differences in the clinical presentation of MDD and a higher rate of suicide in depressed men. To the best of our knowledge, this is the first functional magnetic resonance imaging (fMRI) study with a large sample addressing putative sex differences in MDD during adolescence, a period when one of the most robust findings in psychiatric epidemiology emerges; that females are twice as likely to suffer from MDD than males...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28739537/differing-antidepressant-maintenance-methodologies
#6
REVIEW
Daniel J Safer
BACKGROUND: The principle evidence that antidepressant medication (ADM) is an effective maintenance treatment for adults with major depressive disorder (MDD) is from placebo substitution trials. These trials enter responders from ADM efficacy trials into randomized, double-blind placebo-controlled (RDBPC) effectiveness trials to measure the rate of MDD relapse over time. However, other randomized maintenance trial methodologies merit consideration and comparison. METHODS: A systematic review of ADM randomized maintenance trials included research reports from multiple databases...
July 21, 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/28739277/selection-and-implementation-of-emotion-regulation-strategies-in-major-depressive-disorder-an-integrative-review
#7
REVIEW
Daphne Y Liu, Renee J Thompson
Emotion regulation (ER), broadly defined, has been implicated in mental health, including major depressive disorder (MDD). We review empirical studies examining selection and implementation of ER strategies in adults with current or past MDD. We focus on eight strategies (rumination, distraction, cognitive reappraisal, suppression, acceptance, savoring, positive rumination, dampening), organizing the review by research design: (1) self-reported habitual use (i.e., trait) of ER strategies, (2) spontaneous use of ER strategies in laboratory settings, (3) experimentally instructed ER strategies, and (4) use of ER strategies in naturalistic settings...
July 13, 2017: Clinical Psychology Review
https://www.readbyqxmd.com/read/28739164/a-sparse-representation-based-method-for-parcellation-of-the-resting-brain-and-its-application-to-treatment-resistant-major-depressive-disorder
#8
Ruiyang Ge, Daniel M Blumberger, Jonathan Downar, Zafiris J Daskalakis, Joseph Tham, Raymond Lam, Fidel Vila-Rodriguez
BACKGROUND: Parcellating brain regions into functionally homogeneous subdivisions is critical for understanding normal and abnormal brain functions. NEW METHOD: In this study, we developed a new sparse representation-based parcellation method for functional magnetic resonance imaging (fMRI) data, and applied the new method to investigate functional insular subdivisions in treatment-resistant major depressive disorder (MDD). Realistic simulations were implemented to demonstrate the feasibility of the method...
July 21, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/28738369/inflammatory-and-innate-immune-markers-of-neuroprogression-in-depressed-and-teenage-suicide-brain
#9
Ghanshyam N Pandey
Several studies suggest that major depressive disorder (MDD) and bipolar disorder (BPD) are neuroprogressive illnesses. Besides clinical features, neurobiological mechanisms have been suggested to contribute to the neuroprogression of mood disorders. Biological factors that have been shown to contribute significantly toward the neuroprogressive course of these disorders are inflammatory markers, such as cytokines. Cytokines have been extensively investigated, primarily in the serum of MDD and BPD patients, and these studies show cytokine abnormalities in both adolescent and adult patients with mood disorders...
2017: Modern Trends in Pharmacopsychiatry
https://www.readbyqxmd.com/read/28738332/neuroprogression-and-immune-activation-in-major-depressive-disorder
#10
Jeffrey H Meyer
Traditionally, the neurobiology of major depressive disorder (MDD) has been largely considered from the perspective of the state of major depressive episodes (MDE) versus being in remission, but the current accumulation of disease markers, largely acquired cross-sectionally, is strongly suggestive of neuroprogressive aspects of MDD. This chapter focuses on the changes in disease markers involved in the reorganization of the nervous system in MDD, including the translocator protein (TSPO; an index of microglial activation), glial fibrillary acidic protein (GFAP; an index of astroglial activation), [11C]harmine (a marker of monoamine oxidase A; MAO-A), and several other indices (metabotropic glutamate receptor 5 [mGluR5], excitatory amino acid transporters, and magnetic resonance imaging spectroscopy measurements) of glutamate dysregulation...
2017: Modern Trends in Pharmacopsychiatry
https://www.readbyqxmd.com/read/28735929/electrophysiological-and-microstructural-features-of-sleep-in%C3%A2-children%C3%A2-at-high-risk-for-depression-a-preliminary-study
#11
Gianluca Sesso, Flora Bat-Pitault, Aurore Guyon, Sabine Plancoulaine, Tommaso Banfi, Giulia Milioli, Liborio Parrino, Ugo Faraguna, Patricia Franco
OBJECTIVE: This preliminary study investigated electrophysiological and microstructural features of sleep in children and adolescents 4-18 years of age who were born to depressed mothers. METHODS: A total of 31 healthy subjects (15 male and 16 female) participated in the study. In this sample, 20 children born to mothers diagnosed with Major Depressive Disorder (MDD) were designated as "high-risk"; 11 children born to mothers without a personal history of depression were designated as "low-risk...
August 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28735173/detached-mindfulness-reduced-both-depression-and-anxiety-in-elderly-women-with-major-depressive-disorders
#12
Mohammad Ahmadpanah, Tayebe Akbari, Amineh Akhondi, Mohammad Haghighi, Leila Jahangard, Dena Sadeghi Bahmani, Hafez Bajoghli, Edith Holsboer-Trachsler, Serge Brand
We investigated the influence of detached mindfulness (DM) in treating symptoms of depression and anxiety among elderly women. Thirty-four elderly females (mean age: 69.23 years) suffering from moderate major depressive disorders (MDD) and treated with a standard medication (citalopram) at therapeutic doses were randomly assigned either to an intervention condition (DM; group treatment, twice weekly) or to a control condition (with leisure activities, twice weekly). At baseline (BL), four weeks later at study completion (SC), and four weeks after that at follow-up (FU), participants completed ratings for symptoms of depression and anxiety; experts blind to patients' group assignments rated patients' symptoms of depression...
July 15, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28733886/cognitive-reappraisal-and-depression-in-children-with-a-parent-history-of-depression
#13
Anastacia Y Kudinova, Kiera James, Brandon E Gibb
Although decades of research have documented that children whose parents have a history of Major Depressive Disorder (MDD) are at a higher risk of developing depression themselves, not all of these children go on to develop depression themselves, thus highlighting the need to understand potential moderators of risk. The current study examined whether child emotion regulation, specifically, the use of cognitive reappraisal and suppression, moderated the link between parent and child depression. We recruited 458 parents and their children between the ages of 7-11 from the community...
July 22, 2017: Journal of Abnormal Child Psychology
https://www.readbyqxmd.com/read/28732352/cerebral-blood-flow-changes-in-remitted-early-and-late-onset-depression-patients
#14
Wenxiang Liao, Ze Wang, Xiangrong Zhang, Hao Shu, Zan Wang, Duan Liu, Zhijun Zhang
Abnormal cerebral blood flow (CBF) is reportedly associated with major depressive disorder (MDD). We have investigated CBF changes in early-onset depression (EOD) and late-onset depression (LOD), and their impact on cognitive function. Thirty-two remitted EOD patients, 32 remitted LOD patients, and 43 age-matched healthy controls were recruited, and the pulsed arterial spin labeling data were scanned under 3.0T MRI and processed through voxel-by-voxel statistical analysis. Compared to healthy controls, LOD patients had decreased normalized CBF in the bilateral precuneus, cuneus, right fronto-cingulate-striatal areas, and right temporal, occipital and parietal lobes, but increased normalized CBF in the left frontal and temporal cortices and the cingulate gyrus...
July 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/28731911/expert-and-self-assessment-of-lifetime-symptoms-and-diagnosis-of-major-depressive-disorder-in-large-scale-genetic-studies-in-the-general-population-comparison-of-a-clinical-interview-and-a-self-administered-checklist
#15
Jessica Martin, Fabian Streit, Jens Treutlein, Maren Lang, Josef Frank, Andreas J Forstner, Franziska Degenhardt, Stephanie H Witt, Thomas G Schulze, Sven Cichon, Markus M Nöthen, Marcella Rietschel, Jana Strohmaier
Major depression disorder (MDD) is a complex neuropsychiatric disorder and an increasing number of genetic risk variants are being identified. Investigation of their influence in the general population requires accurate and efficient assessment of depressive symptoms. Here, clinical interviews conducted by clinicians are the gold standard. We investigated whether valid and reliable clinical phenotypes can be obtained efficiently using self-administered instruments. Lifetime depressive symptoms and lifetime MDD diagnosis were assessed in 464 population-based individuals using a clinical interview and a structured, self-administered checklist...
July 20, 2017: Psychiatric Genetics
https://www.readbyqxmd.com/read/28730851/agomelatine-for-the-treatment-of-generalized-anxiety-disorder
#16
Massimiliano Buoli, Silvia Grassi, Marta Serati, A Carlo Altamura
Agomelatine is a melatonergic antidepressant, approved for the treatment of Major Depressive Disorder (MDD) in Europe and Australia, but not in the United States. This compound seems to be promising in the short-term and maintenance treatment of Generalized Anxiety Disorder (GAD). Areas covered: This paper presents an evaluation of the available data about the clinical efficacy and tolerability of agomelatine in the treatment of GAD. Expert opinion: First-line GAD treatments are limited by high rates of lack of clinical response...
July 21, 2017: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/28729943/relationship-between-cerebellar-structure-and-emotional-memory-in-depression
#17
Li-Yan Xu, Fang-Cheng Xu, Can Liu, Yi-Fu Ji, Jin-Min Wu, Ying Wang, Hai-Bao Wang, Yong-Qiang Yu
BACKGROUND: A few studies have been conducted on the relationship between cerebellar volume and emotional memory or clinical severity in major depressive disorder (MDD). In this study, we aimed to compare the volume and density of the cerebellar gray matter (GM) in patients with MDD and in healthy controls (HCs) and explore the association between these cerebellar parameters and measurements of emotional memory and clinical severity. METHOD: Voxel-based morphometry (VBM) and Individual Brain Atlases using Statistical Parametric Mapping (IBASPM) were used to assess GM density and volume in the cerebellum, respectively, in patients with MDD and the HCs...
July 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28729938/abnormal-resting-state-effective-connectivity-within-the-default-mode-network-in-major-depressive-disorder-a-spectral-dynamic-causal-modeling-study
#18
Liang Li, Baojuan Li, Yuanhan Bai, Wenlei Liu, Huaning Wang, Hoi-Chung Leung, Ping Tian, Linchuan Zhang, Fan Guo, Long-Biao Cui, Hong Yin, Hongbing Lu, Qingrong Tan
INTRODUCTION: Understanding the neural basis underlying major depressive disorder (MDD) is essential for the diagnosis and treatment of this mental disorder. Aberrant activation and functional connectivity of the default mode network (DMN) have been consistently found in patients with MDD. It is not known whether effective connectivity within the DMN is altered in MDD. OBJECTS: The primary object of this study is to investigate the effective connectivity within the DMN during resting state in MDD patients before and after eight weeks of antidepressant treatment...
July 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28728097/nonlinear-modulation-of-interacting-between-comt-and-depression-on-brain-function
#19
L Gong, C He, Y Yin, Q Ye, F Bai, Y Yuan, H Zhang, L Lv, H Zhang, Z Zhang, C Xie
BACKGROUND: The catechol-O-methyltransferase (COMT) gene is related to dopamine degradation and has been suggested to be involved in the pathogenesis of major depressive disorder (MDD). However, how this gene affects brain function properties in MDD is still unclear. METHODS: Fifty patients with MDD and 35 cognitively normal participants underwent a resting-state functional magnetic resonance imaging scan. A voxelwise and data-drive global functional connectivity density (gFCD) analysis was used to investigate the main effects and the interactions of disease states and COMT rs4680 gene polymorphism on brain function...
June 9, 2017: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/28728096/early-life-stress-explains-reduced-positive-memory-biases-in-remitted-depression
#20
J A Gethin, K E Lythe, C I Workman, A Mayes, J Moll, R Zahn
BACKGROUND: There is contradictory evidence regarding negative memory biases in major depressive disorder (MDD) and whether these persist into remission, which would suggest their role as vulnerability traits rather than correlates of mood state. Early life stress (ELS), common in patients with psychiatric disorders, has independently been associated with memory biases, and confounds MDD versus control group comparisons. Furthermore, in most studies negative biases could have resulted from executive impairments rather than memory difficulties per se...
July 10, 2017: European Psychiatry: the Journal of the Association of European Psychiatrists
keyword
keyword
13328
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"