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https://www.readbyqxmd.com/read/29778935/different-levels-of-pro-and-anti-inflammatory-cytokines-in-patients-with-unipolar-and-bipolar-depression
#1
Ruizhi Mao, Chen Zhang, Jun Chen, Guoqing Zhao, Rubai Zhou, Fan Wang, Jingjing Xu, Tao Yang, Yousong Su, Jia Huang, Zhiguo Wu, Lan Cao, Yong Wang, Yingyan Hu, Chengmei Yuan, Zhenghui Yi, Wu Hong, Zuowei Wang, Daihui Peng, Yiru Fang
BACKGROUND: Immune system dysregulation is critical in the physiopathology of major depressive disorder (MDD) and bipolar disorder (BD). However, it is unclear whether both diseases present the same inflammatory patterns during depressive episodes. We explored the differences in pro- and anti-inflammatory cytokines between unipolar and bipolar depression (BDD) and the trajectory of these cytokines after acute-phase treatment. METHODS: Sixty-four MDD patients, 61 BDD patients, and 62 healthy controls (HCs) were enrolled...
April 25, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29778712/validation-reliability-and-specificity-of-clinicom%C3%A2-psychiatric-assessment-software
#2
Nelson Handal, James LePage, Philip Dayley, Barbara Baldwin, Amellia Roeser, Joni Kay, Heather Ann Theobald, Michael Nellamattathil, Scott Drotar, Connor Weir, Neil Tindell, Kevin Tice
The purpose of this study was to determine the specificity and reproducibility of CliniCom™ Psychiatric Assessment Software to appropriately diagnose five prevalent mental health disorders. This online assessment tool incorporates proprietary algorithms for its propensity assessment. Unlike other questionnaires, which require a survey per specific mental disorder, CliniCom can simultaneously assess multiple mental disorders for an individual. CliniCom was concordant with other commonly used assessment tools in diagnosing five prevalent disorders including: Attention Deficit and Hyperactivity Disorder, Generalized Anxiety Disorder, Major Depressive Disorder, Obsessive Compulsive Disorder, and Social Phobia...
May 12, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29778546/imaging-genetics-paradigms-in-depression-research-systematic-review-and-meta-analysis
#3
REVIEW
Lícia P Pereira, Cristiano A Köhler, Brendon Stubbs, Kamilla W Miskowiak, Gerwyn Morris, Bárbara P de Freitas, Trevor Thompson, Brisa S Fernandes, André R Brunoni, Michael Maes, Diego A Pizzagalli, André F Carvalho
Imaging genetics studies involving participants with major depressive disorder (MDD) have expanded. Nevertheless, findings have been inconsistent. Thus, we conducted a systematic review and meta-analysis of imaging genetics studies that enrolled MDD participants across major databases through June 30th, 2017. Sixty-five studies met eligibility criteria (N = 4034 MDD participants and 3293 controls), and there was substantial between-study variability in the methodological quality of included studies. However, few replicated findings emerged from this literature with only 22 studies providing data for meta-analyses (882 participants with MDD and 616 controls)...
May 17, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29778071/anxious-distress-in-depressed-outpatients-prevalence-comorbidity-and-incremental-validity
#4
Anthony J Rosellini, Michelle L Bourgeois, Jeannette Correa, Esther S Tung, Svetlana Goncharenko, Timothy A Brown
The goals of this study were to estimate the prevalence of the DSM-5 anxious distress specifier (AD) among depressed outpatients, to examine associations of AD with comorbid diagnoses, and to test the incremental validity of AD over comorbidity in predicting functional impairment and severity of anxiety and depression symptoms. The sample was 237 outpatients diagnosed with major depressive disorder (MDD) or persistent depressive disorder (PDD), with and without AD, using the Anxiety and Related Disorders Interview Schedule for DSM-5...
May 8, 2018: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29777198/aberrant-working-memory-processing-in-major-depression-evidence-from-multivoxel-pattern-classification
#5
Matti Gärtner, M Elisabetta Ghisu, Milan Scheidegger, Luisa Bönke, Yan Fan, Anna Stippl, Ana-Lucia Herrera-Melendez, Sophie Metz, Emilia Winnebeck, Maria Fissler, Anke Henning, Malek Bajbouj, Karsten Borgwardt, Thorsten Barnhofer, Simone Grimm
Major depressive disorder (MDD) is often accompanied by severe impairments in working memory (WM). Neuroimaging studies investigating the mechanisms underlying these impairments have produced conflicting results. It remains unclear whether MDD patients show hyper- or hypoactivity in WM-related brain regions and how potential aberrations in WM processing may contribute to the characteristic dysregulation of cognition-emotion interactions implicated in the maintenance of the disorder. In order to shed light on these questions and to overcome limitations of previous studies, we applied a multivoxel pattern classification approach to investigate brain activity in large samples of MDD patients (N = 57) and matched healthy controls (N = 61) during a WM task that incorporated positive, negative, and neutral stimuli...
May 2, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29776355/can-deep-transcranial-magnetic-stimulation-dtms-be-used-to-treat-substance-use-disorders-sud-a-systematic-review
#6
Karina Karolina Kedzior, Imke Gerkensmeier, Maria Schuchinsky
BACKGROUND: Deep transcranial magnetic stimulation (DTMS) is a non-invasive method of stimulating widespread cortical areas and, presumably, deeper neural networks. The current study assessed the effects of DTMS in the treatment of substance use disorders (SUD) using a systematic review. METHODS: Electronic literature search (PsycInfo, Medline until April 2017) identified k = 9 studies (k = 4 randomized-controlled trials, RCTs, with inactive sham and k = 5 open-label studies)...
May 18, 2018: BMC Psychiatry
https://www.readbyqxmd.com/read/29775886/sprint-interval-training-sit-substantially-reduces-depressive-symptoms-in-major-depressive-disorder-mdd-a-randomized-controlled-trial
#7
Alice Minghetti, Oliver Faude, Henner Hanssen, Lukas Zahner, Markus Gerber, Lars Donath
Continuous aerobic exercise training (CAT) is considered a complementary treatment option in patients with major depressive disorder (MDD). Intermittent exercise training protocols, such as sprint interval training (SIT) have gained increasing popularity, but no studies on depressive symptoms following SIT in patients with MDD are available. Fifty-nine in-patients with MDD were randomly assigned to a SIT or CAT group. Medication was counterbalanced in both intervention arms. Both intervention groups received 3 weekly training sessions for 4-weeks (12 sessions in total)...
May 8, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29770839/are-multidose-drug-dispensing-systems-initiated-for-the-appropriate-patients
#8
Bram J Mertens, H F Kwint, Rob J van Marum, Marcel L Bouvy
PURPOSE: It is unknown if multidose drug dispensing (MDD) systems are initiated for the appropriate patients. Therefore, the objective of this study was to compare the medication management problems of patients who were about to start with a MDD system (MDD patients) and patients who continued manually dispensed medication (non-MDD users) in order to identify if the appropriate patients receive a MDD system. METHODS: Patient interviews (semi-structured) were conducted by 44 community pharmacists at the patient's home...
May 16, 2018: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29769159/empirical-evidence-for-definitions-of-episode-remission-recovery-relapse-and-recurrence-in-depression-a-systematic-review
#9
P L de Zwart, B F Jeronimus, P de Jonge
AIMS: For the past quarter of a century, Frank et al.'s (1991) consensus-based definitions of major depressive disorder (MDD) episode, remission, recovery, relapse and recurrence have been the paramount driving forces for consistency in MDD research as well as in clinical practice. This study aims to review the evidence for the empirical validation of Frank et al.'s proposed concept definitions and to discuss evidence-based modifications. METHODS: A literature search of Web of Science and PubMed from 1/1/1991 to 08/30/2017 identified all publications which referenced Frank et al...
May 17, 2018: Epidemiology and Psychiatric Sciences
https://www.readbyqxmd.com/read/29764522/treatment-resistant-depression-and-peripheral-c-reactive-protein
#10
Samuel R Chamberlain, Jonathan Cavanagh, Peter de Boer, Valeria Mondelli, Declan N C Jones, Wayne C Drevets, Philip J Cowen, Neil A Harrison, Linda Pointon, Carmine M Pariante, Edward T Bullmore
BACKGROUND: C-reactive protein (CRP) is a candidate biomarker for major depressive disorder (MDD), but it is unclear how peripheral CRP levels relate to the heterogeneous clinical phenotypes of the disorder.AimTo explore CRP in MDD and its phenotypic associations. METHOD: We recruited 102 treatment-resistant patients with MDD currently experiencing depression, 48 treatment-responsive patients with MDD not currently experiencing depression, 48 patients with depression who were not receiving medication and 54 healthy volunteers...
May 16, 2018: British Journal of Psychiatry: the Journal of Mental Science
https://www.readbyqxmd.com/read/29763645/agmatine-potentiates-neuroprotective-effects-of-subthreshold-concentrations-of-ketamine-via-mtor-s6-kinase-signaling-pathway
#11
Mauren K Tavares, Suellen Dos Reis, Nicolle Platt, Isabella A Heinrich, Ingrid A V Wolin, Rodrigo B Leal, Manuella P Kaster, Ana Lúcia S Rodrigues, Andiara E Freitas
Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis is one of the most robust neurobiological findings in the pathophysiology of major depressive disorder (MDD) over the last 40 years. The persistent increase in glucocorticoids levels induces morphological and anatomical changes in the brain, especially in the hippocampus. Ketamine represents a major advance for the treatment of MDD, however the psychotomimetic effects of this compound limit its widespread use. Agmatine is a neuromodulator that has been shown to be a putative novel and well-tolerated antidepressant/augmenter drug...
May 12, 2018: Neurochemistry International
https://www.readbyqxmd.com/read/29759821/using-multilevel-modeling-to-examine-blunted-neural-responses-to-reward-in-major-depression
#12
Christopher J Brush, Peter J Ehmann, Greg Hajcak, Edward A Selby, Brandon L Alderman
BACKGROUND: Major depressive disorder (MDD) is a pernicious disorder characterized by deficits in reward processing. A better understanding of these deficits may help to elucidate the underlying pathophysiology and guide treatment development. METHODS: This study assessed reward positivity and feedback negativity event-related potentials and their difference scores elicited in response to monetary gains and losses among 100 young adults (52 with MDD). Multilevel modeling was used to assess individual- and trial-level change in neural responses over time...
April 17, 2018: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://www.readbyqxmd.com/read/29759000/biological-sex-differences-in-depression-a-systematic-review
#13
Ainitze Labaka, Olatz Goñi-Balentziaga, Andrea Lebeña, Joana Pérez-Tejada
Depression is the leading cause of disability worldwide, and its prevalence is 2 times higher in women than in men. There is, however, a lack of data on sex-specific pathophysiology of this disorder. The purpose of this systematic review is to identify the biological sex differences found in major depressive disorder (MDD) in studies published in the last 10 years. We conducted a literature search using the Medline, PsycInfo, PubMed, and Web of Science databases, selecting English-language studies that included physiological measures compared by sex in addition to MDD...
January 1, 2018: Biological Research for Nursing
https://www.readbyqxmd.com/read/29756958/poor-breastfeeding-complementary-feeding-and-dietary-diversity-in-children-and-their-relationship-with-stunting-in-rural-communities
#14
Jessica Zaragoza Cortes, Luis Eduardo Trejo Osti, Moisés Ocampo Torres, Laura Maldonado Vargas, Alicia Arminda Ortiz Gress
INTRODUCTION: stunted growth is the most common manifestation of malnutrition in México. Breastfeeding, adequate introduction of complementary feeding and dietary diversity can avoid this. OBJECTIVE: to characterize the feeding practices in children 1-24 months of age in rural communities of Hidalgo and define their relationship with stunting. METHODS: a 24-hour recall was used to obtain information. Z-scores for length-for-age (ZLA), complementary feeding (CF) and minimal dietary diversity (MDD) were determined...
February 27, 2018: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/29756354/neural-correlates-of-suicidality-in-adolescents-with-major-depression-resting-state-functional-connectivity-of-the-precuneus-and-posterior-cingulate-cortex
#15
Melinda Westlund Schreiner, Bonnie Klimes-Dougan, Kathryn R Cullen
OBJECTIVE: Major depressive disorder (MDD) is associated with suicidal thoughts and behaviors ("suicidality"). Of the three components of Joiner's interpersonal theory of suicide, two involve negatively valenced, self-related beliefs: perceived burdensomeness and thwarted belongingness. However, the neurocircuitry underlying self-processing and suicidality has not been fully explored. This study examined the association between suicidality and the neurocircuitry of regions relevant to self-referential processing in adolescents with depression...
May 13, 2018: Suicide & Life-threatening Behavior
https://www.readbyqxmd.com/read/29753295/major-depressive-disorder-in-epilepsy-clinics-a-meta-analysis
#16
REVIEW
Minjung Kim, Young-Soo Kim, Do-Hyung Kim, Tae-Won Yang, Oh-Young Kwon
BACKGROUND AND PURPOSE: Although depression is a frequent psychiatric comorbidity in people with epilepsy (PWE), its prevalence has been underestimated. Comorbid depression has negative impacts on treatment outcomes and quality of life (QOL). It also causes various problems in PWE, such as fatigue, irritability, and suicidality. This meta-analysis was performed to estimate the frequency of major depression disorder (MDD) in clinics managing PWE. METHODS: We searched MEDLINE, EMBASE, Cochrane Library, Web of Science, and SCOPUS to identify studies...
May 9, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29753198/prefrontal-alterations-in-gabaergic-and-glutamatergic-gene-expression-in-relation-to-depression-and-suicide
#17
J Zhao, R W H Verwer, S-F Gao, X-R Qi, P J Lucassen, H W Kessels, D F Swaab
People that committed suicide were reported to have enhanced levels of gene transcripts for synaptic proteins in their prefrontal cortex (PFC). Given the close association of suicide with major depressive disorder (MDD), we here assessed whether these changes are related to suicide or rather to depression per se. We used quantitative PCR to determine mRNA levels of 32 genes encoding for proteins directly involved in glutamatergic or GABAergic synaptic transmission in postmortem samples of the anterior cingulate cortex (ACC) and the dorsolateral PFC (DLPFC)...
April 30, 2018: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29752492/novel-antidepressant-effects-of-paeonol-alleviate-neuronal-injury-with-concomitant-alterations-in-bdnf-rac1-and-rhoa-levels-in-chronic-unpredictable-mild-stress-rats
#18
Xiu-Ling Zhu, Jing-Jing Chen, Fei Han, Chuan Pan, Ting-Ting Zhuang, Ya-Fei Cai, Ya-Ping Lu
RATIONALE: Increasing evidence has suggested that major depressive disorder (MDD) is highly associated with brain-derived neurotrophic factor (BDNF) levels, dendrites atrophy, and loss of dendritic spines, especially in emotion-associated brain regions including the hippocampus. Paeonol is a kind of polyphenols natural product with a variety of therapeutic effects. Recent studies have reported its antidepressant effects. However, it is unclear what signaling pathways contribute to improve MDD...
May 12, 2018: Psychopharmacology
https://www.readbyqxmd.com/read/29751242/local-functional-connectivity-alterations-in-schizophrenia-bipolar-disorder-and-major-depressive-disorder
#19
Yange Wei, Miao Chang, Fay Y Womer, Qian Zhou, Zhiyang Yin, Shengnan Wei, Yifang Zhou, Xiaowei Jiang, Xudong Yao, Jia Duan, Ke Xu, Xi-Nian Zuo, Yanqing Tang, Fei Wang
BACKGROUND: Local functional connectivity (FC) indicates local or short-distance functional interactions and may serve as a neuroimaging marker to investigate the human brain connectome. Local FC alterations suggest a disrupted balance in the local functionality of the whole brain network and are increasingly implicated in schizophrenia (SZ), bipolar disorder (BD), and major depressive disorder (MDD). METHODS: We aim to examine the similarities and differences in the local FC across SZ, BD, and MDD...
April 10, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29748628/7t-1-h-mrs-in-major-depressive-disorder-a-ketamine-treatment-study
#20
Jennifer W Evans, Níall Lally, Li An, Ningzhi Li, Allison C Nugent, Dipavo Banerjee, Sam L Snider, Jun Shen, Jonathan P Roiser, Carlos A Zarate
The glutamatergic modulator ketamine has striking and rapid antidepressant effects in major depressive disorder (MDD), but its mechanism of action remains unknown. Proton magnetic resonance spectroscopy (1H-MRS) is the only non-invasive method able to directly measure glutamate levels in vivo; in particular, glutamate and glutamine metabolite concentrations are separable by 1H-MRS at 7T. This double-blind, placebo-controlled, crossover study that included 1 H-MRS scans at baseline and at 24 h post ketamine and post-placebo infusions sought to determine glutamate levels in the pregenual anterior cingulate (pgACC) of 20 medication-free MDD subjects and 17 healthy volunteers (HVs) 24 h post ketamine administration, and to evaluate any other measured metabolite changes, correlates, or predictors of antidepressant response...
April 5, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
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