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vitamin d and pregnant

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https://www.readbyqxmd.com/read/27904548/the-effect-of-vitamin-d-supplementation-on-gestational-diabetes-in-high-risk-women-results-from-a-randomized-placebo-controlled-trial
#1
Shole Shahgheibi, Fariba Farhadifar, Bahar Pouya
BACKGROUND: Vitamin D deficiency is common in pregnancy, leading to increase in the frequency of preeclampsia, cesarean delivery, neonatal bacterial vaginosis, and gestational diabetes. The current study was designed and implemented to investigate the effect of vitamin D during the first and second trimesters of pregnancy in reducing the risk of gestational diabetes mellitus (GDM) in women who are at high risk [history of GDM, birth macrosomia, family history, and high body mass index (BMI)]...
2016: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/27903815/neonatal-vitamin-d-status-and-risk-of-multiple-sclerosis-a-population-based-case-control-study
#2
Nete Munk Nielsen, Kassandra L Munger, Nils Koch-Henriksen, David M Hougaard, Melinda Magyari, Kristian T Jørgensen, Marika Lundqvist, Jacob Simonsen, Tine Jess, Arieh Cohen, Egon Stenager, Alberto Ascherio
OBJECTIVE: As previous research has suggested that exposure to vitamin D insufficiency in utero may have relevance for the risk of multiple sclerosis (MS), we aimed to examine the direct association between level of neonatal vitamin D and risk of MS. METHODS: We carried out a matched case-control study. Dried blood spots samples (DBSS) belonging to 521 patients with MS were identified in the Danish Newborn Screening Biobank. For every patient with MS, 1-2 controls with the same sex and birth date were retrieved from the Biobank (n = 972)...
November 30, 2016: Neurology
https://www.readbyqxmd.com/read/27903510/vitamin-d-supplementation-reduces-some-at1-aa-induced-downstream-targets-implicated-in-preeclampsia-including-hypertension
#3
Jessica L Faulkner, Lorena M Amaral, Denise C Cornelius, Mark W Cunningham, Tarek Ibrahim, Autumn Heep, Nathan Campbell, Nathan Usry, Kedra Wallace, Florian Herse, Ralf Dechend, Babbette D LaMarca
Autoantibodies to the angiotensin II (ANGII) type I receptor (AT1-AA) are associated with preeclampsia (PE). We found that Vitamin D supplementation reduced AT1-AA and blood pressure (MAP) in the RUPP rat model of PE. However, it was undetermined if the decrease in AT1-AA was the mechanism whereby Vitamin D lowered MAP or if it was through factors downstream of AT1-AA. Uterine artery resistance index, placental ET-1 and sFlt-1 are increased with AT1-AA induced hypertension and considered markers of PE in pregnant women...
November 30, 2016: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/27896937/effect-of-tailored-dietary-guidance-for-pregnant-women-on-nutritional-status-a-double-cohort-study
#4
Megumi Haruna, Mie Shiraishi, Masayo Matsuzaki, Yuko Yatsuki, SeonAe Yeo
This double cohort study aimed to evaluate the effect of tailored dietary guidance for pregnant women on dietary intake, nutritional status, and infant birth weight. Healthy pregnant women were recruited at an antenatal clinic during two phases over 2 years. The historical controls were analyzed a year prior to the intervention group. In both groups, data were collected at 19-26 gestational weeks (baseline) and at 34-37 gestational weeks (outcome measurement). The intervention included the following: (a) assessments of maternal dietary nutritional intake using the brief self-administered diet history questionnaire, (b) individual feedback based on the assessments of maternal nutritional status, (c) tailored guidance for a healthy diet, (d) original cooking recipes, and (e) goal sharing...
November 29, 2016: Maternal & Child Nutrition
https://www.readbyqxmd.com/read/27870560/effect-of-prenatal-versus-postnatal-vitamin-d-deficiency-on-pulmonary-structure-and-function-in-mice
#5
Ammar Saadoon, Namasivayam Ambalavanan, Kurt Zinn, Ambika P Ashraf, Mark MacEwen, Teodora Nicola, Michelle V Fanucchi, William T Harris
Epidemiologic studies have linked gestational vitamin D deficiency to respiratory diseases, although mechanisms have not been defined. We hypothesized that antenatal vitamin D deficiency would impair airway development and alveolarization in a mouse model. We studied the effect of antenatal vitamin D deficiency by inducing vitamin D deficiency in pregnant mice and then compared lung development and function in their offspring to littermate controls. Postnatal vitamin D deficiency and sufficiency models from each group were also studied...
November 21, 2016: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/27862673/vitamin-d-restores-angiogenic-balance-and-decreases-tumor-necrosis-factor-%C3%AE-in-a-rat-model-of-pre-eclampsia
#6
Jing Song, Yue Li, Ruifang An
AIM: Deficiency of vitamin D is correlated with pre-eclampsia (PE), a hypertensive disorder of pregnancy, and is characterized by angiogenic imbalance and inflammation. The aim of this study was to investigate whether vitamin D supplementation can restore the angiogenic balance and ameliorate inflammation in a rat model of PE. METHODS: PE was induced using l-nitroarginine methylester. Normal pregnant and PE-induced rats were supplemented with vitamin D on gestation days 14-19...
November 12, 2016: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/27851719/the-correlation-between-serum-vitamin-d-deficiency-and-preterm-birth
#7
Lixia Yang, Shilei Pan, Yufeng Zhou, Xiaoyang Wang, Aikai Qin, Yuxin Huang, Suxia Sun
BACKGROUND Preterm birth is an important cause of death and developmental disorder in neonates. Vitamin D deficiency has been shown to regulate body inflammatory factor levels that stimulate elevation of uterine contraction hormones, such as prostaglandin, thus causing preterm birth. However, current observations regarding the relationship between vitamin D and preterm birth are inconsistent. We performed a nested case-control study to investigate the effect of vitamin D on preterm birth. MATERIAL AND METHODS A prospective cohort study included 200 cases of pregnant women in our hospital from May 2013 to May 2015...
November 16, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27846821/long-term-adherence-and-effects-on-grip-strength-and-upper-leg-performance-of-prescribed-supplemental-vitamin-d-in-pregnant-and-recently-pregnant-women-of-somali-and-swedish-birth-with-25-hydroxyvitamin-d-deficiency-a-before-and-after-treatment-study
#8
Paul Kalliokoski, Nils Rodhe, Yngve Bergqvist, Monica Löfvander
BACKGROUND: Muscular weakness and severe vitamin D deficiency is prevalent in Somali (veiled) pregnant women, Sweden. The study aims here were to explore adherence to prescribed supplemental vitamin D in new mothers with vitamin D deficiency and its effects on grip strength and upper leg performance in Somali (target group TG) and Swedish women (reference group RG) from spring through winter. METHODS: A before- and after study was designed. A cross-sectional sample of women in antenatal care with serum 25-OHD ≤50 nmol/L were prescribed one or two tablets daily (800 or 1600 IU vitamin D3 with calcium) for 10 months...
November 15, 2016: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/27836660/decreased-nutrient-intake-is-associated-with-premature-cervical-remodeling
#9
Mary Dawn Koenig, Barbara L McFarlin, Alana D Steffen, Lisa Tussing-Humphreys, Carmen Giurgescu, Christopher G Engeland, Michelle A Kominiarek, Christina Ciezczak-Karpiel, William D O'Brien, Rosemary White-Traut
OBJECTIVE: To examine the direct relationship between nutrient intake and cervical remodeling. DESIGN: Longitudinal descriptive design. SETTING: Maternal-fetal medicine clinic in a Midwestern urban city. PARTICIPANTS: Forty-seven pregnant African American women. METHODS: Participants completed the Block brief food frequency questionnaire at 19 to 24 weeks and 27 to 29 weeks gestation and had quantitative ultrasonic attenuation estimates at 19 to 21 weeks, 23 to 25 weeks, 27 to 29 weeks, 31 to 33 weeks, and 35 to 37 weeks gestation...
November 8, 2016: Journal of Obstetric, Gynecologic, and Neonatal Nursing: JOGNN
https://www.readbyqxmd.com/read/27834063/clinical-utility-of-measurement-of-vitamin-d-binding-protein-and-calculation-of-bioavailable-vitamin-d-in-assessment-of-vitamin-d-status
#10
Hyun Jeong Kim, Misuk Ji, Junghan Song, Hee Won Moon, Mina Hur, Yeo Min Yun
BACKGROUND: The associations of vitamin D deficiency with various clinical conditions highlighted the importance of vitamin D testing. Currently, clinicians measure only the total 25-hydroxyvitamin D [25(OH)D] concentration, regardless of its bioavailability. We aimed to determine the effect of vitamin D-binding protein (VDBP) on 25(OH)D bioavailability. METHODS: Serum samples were collected from 60 healthy controls, 50 pregnant women, and 50 patients in intensive care units (ICUs)...
January 2017: Annals of Laboratory Medicine
https://www.readbyqxmd.com/read/27826434/development-and-piloting-of-a-food-based-intervention-to-increase-vitamin-e-intake-in-pregnant-women-in-a-randomized-controlled-trial
#11
Julia Clark, Nikki Holgan, Leone Craig, Heather Morgan, Peter Danielian, Graham Devereux
Low maternal vitamin E intake during pregnancy is associated with childhood asthma and a trial is required to test whether increasing maternal vitamin E intake reduces childhood asthma. This study investigated whether such a trial is possible using food to increase vitamin E intake. Three soup varieties with enhanced vitamin E content (16-19 mg/can) from food ingredients were developed. Near identical retail versions (vitamin E 1-4 mg/can) acted as placebo. In a pilot double-blind randomized controlled trial, pregnant women were randomized 1:1 to enhanced or placebo soups (three tins/week) from 12 weeks gestation to delivery...
November 2016: Food Science & Nutrition
https://www.readbyqxmd.com/read/27817876/vitamin-d-supplementation-cord-25-hydroxyvitamin-d-and-birth-weight-findings-from-the-odense-child-cohort
#12
Sine Lykkedegn, Signe Sparre Beck-Nielsen, Grith Lykke Sorensen, Louise Bjoerkholt Andersen, Palle Bach Nielsen Fruekilde, Jan Nielsen, Henriette Boye Kyhl, Jan Stener Joergensen, Steffen Husby, Henrik Thybo Christesen
BACKGROUND & AIMS: Hypovitaminosis D, defined as serum 25-hydroxyvitamin D (s-25(OH)D) <50 nmol/L, is frequent in pregnant women and neonates worldwide and has been associated with both low birth weight (BW) and placental weight (PW) as well as reduced placental development. We aimed to assess the prevalence and the risk factors of cord vitamin D deficiency (s-25(OH)D <25 nmol/L) and insufficiency (s-25(OH)D 25-50 nmol/L) and to evaluate the association between cord s-25(OH)D levels and neonatal outcomes (BW, PW and PW/BW ratio)...
October 27, 2016: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/27807601/maternal-dietary-nutrient-intake-during-pregnancy-and-offspring-linear-growth-and-bone-the-vitamin-d-in-pregnancy-cohort-study
#13
Natalie K Hyde, Sharon L Brennan-Olsen, John D Wark, Sarah M Hosking, Julie A Pasco
Magnesium, phosphorus, zinc, calcium, potassium and protein all play integral roles in maintaining bone health in adults; however, less is known about the importance of these minerals in utero. We aimed to determine associations between maternal dietary consumption of these nutrients during gestation and birth measures in offspring. Of 475 pregnant women recruited from a single antenatal clinic before 16-week gestation (2002-2003) as part of the vitamin D in pregnancy study, 346 with recorded maternal dietary intakes at 28- to 32-week gestation and offspring measures at birth were included...
November 2, 2016: Calcified Tissue International
https://www.readbyqxmd.com/read/27795767/vitamin-d-status-in-moroccan-pregnant-women-and-newborns-reports-of-102-cases
#14
Fouzia Mnebhi Loudyi, Jalal Kassouati, Meryem Kabiri, Naima Chahid, Aicha Kharbach, Hassan Aguenaou, Amina Barkat
INTRODUCTION: Vitamin D insufficiency to pregnant women has been associated with a number of adverse consequences, and has been recognized as a public health concern. The aim of this study was to evaluate vitamin D status of Morrocan pregnant women and their newborns. Our study is being the first of its kind in Morocco, as it supports the program of systematic supplementation of pregnant women in the third quarter. Its results have established a new program for the fight against the deficit of various nutrients, thereby intake of vitamin D has become routine...
2016: Pan African Medical Journal
https://www.readbyqxmd.com/read/27793368/loss-of-placental-thrombomodulin-in-oocyte-donation-pregnancies
#15
Manon Bos, Hans J Baelde, Jan A Bruijn, Kitty W M Bloemenkamp, Marie-Louise P van der Hoorn, Rosanne J Turner
OBJECTIVE: To investigate whether thrombomodulin dysregulation is involved in the development of preeclampsia after oocyte donation (OD). Women who become pregnant after OD are prone to develop preeclampsia, a syndrome characterized by an aberrant immunologic response, hypercoagulability, and endothelial dysfunction. A mediator of inflammation and coagulation is thrombomodulin, which has a possible role to play in this syndrome. DESIGN: Case-control study. SETTING: Not applicable...
October 25, 2016: Fertility and Sterility
https://www.readbyqxmd.com/read/27788053/determinants-of-the-maternal-25-hydroxyvitamin-d-response-to-vitamin-d-supplementation-during-pregnancy
#16
Rebecca J Moon, Nicholas C Harvey, Cyrus Cooper, Stefania D'Angelo, Sarah R Crozier, Hazel M Inskip, Inez Schoenmakers, Ann Prentice, Nigel K Arden, Nicholas J Bishop, Andrew Carr, Elaine M Dennison, Richard Eastell, Robert Fraser, Saurabh V Gandhi, Keith M Godfrey, Stephen Kennedy, M Zulf Mughal, Aris T Papageorghiou, David M Reid, Sian M Robinson, M Kassim Javaid
CONTEXT: Current approaches to antenatal vitamin D supplementation do not account for interindividual differences in 25-hydroxyvitamin D (25(OH)D) response. OBJECTIVE: We assessed which maternal and environmental characteristics were associated with 25(OH)D after supplementation with cholecalciferol. DESIGN: Within-randomization-group analysis of participants in the Maternal Vitamin D Osteoporosis Study trial of vitamin D supplementation in pregnancy...
October 27, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27764194/vitamin-d-deficiency-increases-the-risk-of-adverse-neonatal-outcomes-in-gestational-diabetes
#17
Letícia Schwerz Weinert, Angela Jacob Reichelt, Leonardo Rauber Schmitt, Roberta Boff, Maria Lucia Rocha Oppermann, Joiza Lins Camargo, Sandra Pinho Silveiro
BACKGROUND: Gestational diabetes mellitus (GDM) and vitamin D deficiency have been associated with increased risk of adverse perinatal outcomes but the consequences of both conditions simultaneously present in pregnancy have not yet been evaluated. Our objective was to study the influence of vitamin D deficiency in neonatal outcomes of pregnancies with GDM. METHODS: 184 pregnant women with GDM referred to specialized prenatal monitoring were included in this cohort and had blood sampled for 25-hydroxyvitamin D measurement...
2016: PloS One
https://www.readbyqxmd.com/read/27764169/maternal-vitamin-d-status-at-week-30-of-gestation-and-offspring-cardio-metabolic-health-at-20-years-a-prospective-cohort-study-over-two-decades
#18
Dorte Rytter, Bodil Hammer Bech, Thorhallur Ingi Halldorsson, Tine Brink Henriksen, Charlotta Grandström, Arieh Cohen, Sjurdur Frodi Olsen
BACKGROUND/OBJECTIVES: Vitamin D deficiency is common among pregnant women and since the fetus relies exclusively on maternal supply, deficiency could potentially interfere with fetal development. Vitamin D blood concentrations during pregnancy have been associated with offspring cardio-metabolic health in a few previous studies but the evidence is still inconsistent and only one previous study has followed the offspring into adulthood. The aim of the present study was to investigate the association between maternal serum concentration of vitamin D (25(OH)D) in week 30 of gestation and offspring cardio-metabolic risk factors at 20 years...
2016: PloS One
https://www.readbyqxmd.com/read/27760474/maternal-serum-vitamin-d-levels-and-pregnancy-outcomes-from-lagos-nigeria
#19
Abidoye Gbadegesin, Adekunle Sobande, Oluwole Adedeji, Elizabeth Disu, Oluwatosin Korede, Adedoyin Dosunmu, Adebusola Shakunle
In an attempt to investigate the effect of vitamin D deficiency on pregnancy complications including caesarean section and foetal outcome in our population, blood samples of 461 pregnant women who attended antenatal booking clinic between 10 and 28 weeks of pregnancy were taken for vitamin D estimation and followed up. Details concerning pregnancy complications, labour and foetal outcome were obtained after delivery. They were divided into three groups according to the serum vitamin D level: group 1 (0-20)ng/ml (deficiency), group 2 (21-30)ng/ml (insufficiency), and group 3 (more than 30 mg/ml) normal...
October 20, 2016: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/27756413/fat-and-vitamin-intakes-during-pregnancy-have-stronger-relations-with-a-pro-inflammatory-maternal-microbiota-than-does-carbohydrate-intake
#20
Siddhartha Mandal, Keith M Godfrey, Daniel McDonald, Will V Treuren, Jørgen V Bjørnholt, Tore Midtvedt, Birgitte Moen, Knut Rudi, Rob Knight, Anne Lise Brantsæter, Shyamal D Peddada, Merete Eggesbø
BACKGROUND: Although diet is known to have a major modulatory influence on gut microbiota, knowledge of the specific roles of particular vitamins, minerals, and other nutrients is limited. Modulation of the composition of the microbiota in pregnant women is especially important as maternal microbes are transferred during delivery and initiate the colonization process in the infant. We studied the associations between intake of specific dietary nutrients during pregnancy and gut microbiota composition...
October 19, 2016: Microbiome
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