Xing Jin, Lei Liu, Dan Liu, Jia Wu, Congcong Wang, Siliang Wang, Fengying Wang, Guanzhen Yu, Xiaoxia Jin, Yu-Wen Xue, Dan Jiang, Yan Ni, Xi Yang, Ming-Song Wang, Zhi-Wei Wang, Yuriy L Orlov, Wei Jia, Gerry Melino, Ji-Bin Liu, Wen-Lian Chen
Esophageal squamous cell carcinoma (ESCC) is a deadly malignancy with notable metabolic reprogramming, yet the pivotal metabolic feature driving ESCC progression remains elusive. Here, we show that methionine cycle exhibits robust activation in ESCC and is reversely associated with patient survival. ESCC cells readily harness exogenous methionine to generate S-adenosyl-methionine (SAM), thus promoting cell proliferation. Mechanistically, methionine augments METTL3-mediated RNA m6 A methylation through SAM and revises gene expression...
April 3, 2024: Cell Death and Differentiation