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https://www.readbyqxmd.com/read/28548897/evening-light-exposure-to-computer-screens-disrupts-human-sleep-biological-rhythms-and-attention-abilities
#1
A Green, M Cohen-Zion, A Haim, Y Dagan
The use of electronic devices with light-emitting screens has increased exponentially in the last decade. As a result, humans are almost continuously exposed to unintentional artificial light. We explored the independent and combined effects of two aspects of screen illumination, light wavelength, and intensity, on sleep, its biological regulation, and related functional outcomes. The 2 × 2 repeated-measure design included two independent variables: screen light intensity (low ([LI] versus high [HI]) and wavelength (short [SWL] versus long [LWL])...
May 26, 2017: Chronobiology International
https://www.readbyqxmd.com/read/28547936/fragment-based-drug-discovery-as-alternative-strategy-to-the-drug-development-for-neglected-diseases
#2
REVIEW
Juliana da Fonseca Rezende E Mello, Renan Augusto Gomes, Drielli Gomes Vital-Fujii, Glaucio Monteiro Ferreira, Gustavo Henrique Goulart Trossini
Neglected diseases (NDs) affect large populations and almost whole continents, representing 12% of the global health burden. In contrast, the treatment available today is limited and sometimes ineffective. Under this scenery, the Fragment-Based Drug Discovery (FBDD) emerged as one of the most promising alternatives to the traditional methods of drug development. This method allows achieving new lead compounds with smaller size of fragment libraries. Even with the wide Fragment-Based Drug Discovery success resulting in new effective therapeutic agents against different diseases, until this moment few studies have been applied this approach for NDs area...
May 26, 2017: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/28547934/endo-laparoscopic-inguinal-hernia-repair-what-is-its-role
#3
REVIEW
Anil Sharma, Priyank Chelawat
Hernia repair techniques vary greatly depending upon the setting, surgeons, insurance reimbursement systems, resources, and logistical capabilities. Open mesh repair is the most frequently used technique. Choosing the best technique for inguinal hernia repair is a challenge. There is no single technique to manage every type of hernia. Today, laparoscopy and robotics are at the forefront of advanced surgical tools and offer a range of options for general surgeons who are critically evaluating new procedures...
May 2017: Asian Journal of Endoscopic Surgery
https://www.readbyqxmd.com/read/28547519/kurt-goldstein-and-his-nonlocationist-thoughts-on-aphasia-a-pioneer-of-early-network-theories-at-the-beginning-of-the-twentieth-century
#4
Holger Joswig, Gerhard Hildebrandt
In between Carl Wernicke's locationist aphasia concept from 1874 and Norman Geschwind's new connectionist model of human brain functions in 1965, little notice was taken of the historical debate on aphasia and brain plasticity. Interestingly, Kurt Goldstein made long-forgotten, but highly relevant remarks on the connectionist model and thereby served as an important connecting link between Wernicke and Geschwind. With the original contributions of Goldstein and contemporary authors, we analyzed the historical background of the aphasia debate in the time period between Wernicke and Geschwind, which still influences current aphasia concepts and neurosurgical practice of today...
May 25, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28546777/effectiveness-of-a-participatory-eye-care-program-in-reducing-eye-strain-among-staff-computer-users-in-thailand
#5
Sudaw Lertwisuttipaiboon, Tepanata Pumpaibool, Karl J Neeser, Ngamjit Kasetsuwan
BACKGROUND: The increased usage of computers results in a variety of health problems, particularly eye strain, which is the most common workplace complaint today. OBJECTIVES: This study aimed to evaluate the effectiveness of a participatory eye care (PEC) program by comparing eye care knowledge, attitude, and practice (KAP), as well as eye strain symptoms in staff computer users at Sukhothai Thammathirat Open University, Thailand. METHODS: A participatory approach was held by organizing a meeting of 26 stakeholders to get opinions for developing the PEC program...
2017: Risk Management and Healthcare Policy
https://www.readbyqxmd.com/read/28546768/effectiveness-of-various-formulations-of-local-anesthetics-and-additives-for-topical-anesthesia-a-prospective-randomized-double-blind-placebo-controlled-study
#6
Christian Weilbach, Christian Hoppe, Matthias Karst, Michael Winterhalter, Konstantinos Raymondos, Arthur Schultz, Niels Rahe-Meyer
BACKGROUND: Topical anesthesia is used to control pain associated with many procedures in medicine. Today, the product most commonly applied for topical anesthesia in Germany is EMLA(®) (lidocaine/prilocaine). However, since prilocaine is a methemoglobin-inducing agent, there are limitations to its use, especially in neonates and infants. The aim of this study was to evaluate the effect of prilocaine and lidocaine as well as propylene glycol, a penetration enhancer, and trometamol, a buffer substance, in anesthetic creams...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28546680/the-impact-of-the-yogic-lifestyle-on-cancer-prognosis-and-survival-can-we-target-cancer-stem-cells-with-yoga
#7
Kavita Beri
Cancer has recently been known to originate from stem cell-like cells, called cancer stem cells (CSCs). Their unique properties of self-duplication, multiplication, as well as migration give the CSC resistance over conventional cancer therapies. Newer therapies are in developmental stage to target these stem cell-like populations and become the vanguard of future treatments. Several complementary and alternative treatments have been used in cancer management as an adjunct to conventional therapy to improve the overall quality of life and reduce recurrence...
May 2017: International Journal of Yoga
https://www.readbyqxmd.com/read/28546462/alternative-donor-graft-sources-for-adults-with-hematologic-malignancies-a-donor-for-all-patients-in-2017
#8
REVIEW
Tamila L Kindwall-Keller, Karen K Ballen
Hematopoietic stem cell transplant (HSCT) is potentially curative for a wide variety of malignant diseases, including acute and leukemias, lymphoma, and myelodysplasia. Choice of a stem cell donor is dependent on donor availability, donor compatibility and health, recipient disease type, and recipient condition. Current sources of stem cell donation for HSCT are matched sibling donors (MSDs), matched unrelated donors (MUDs), 1-antigen mismatched unrelated donors (MMUDs), haploidentical donors (haplo), and umbilical cord blood (UCB) units...
May 25, 2017: Oncologist
https://www.readbyqxmd.com/read/28546370/pediatric-oxygen-therapy-a-review-and-update
#9
Brian K Walsh, Craig D Smallwood
Oxygen is a colorless, odorless, tasteless gas that is utilized by the body for respiration. Oxygen has played a major role in respiratory care. Oxygen therapy is useful in treating hypoxemia but is often thought of as a benign therapy. After many years of study, we have learned a great deal of the benefits and potential risk of this powerful drug. Today oxygen gas is cheap, widely available, and easy to administer. Oxygen delivery devices vary in cost from a few cents for a simple nasal cannula to $25-$50 for some humidified systems...
June 2017: Respiratory Care
https://www.readbyqxmd.com/read/28546061/primary-biliary-cholangitis-advances-in-management-and-treatment-of-the-disease
#10
Pietro Invernizzi', Annarosa Floreani, Marco Carbone, Marco Marzioni, Antonio Craxi, Luigi Muratori, Umberto Vespasiani Gentilucci, Ivan Gardini, Antonio Gasbarrini, Paola Krugeri, Francesco Saverio Mennini, Virginia Ronco, Elena Lanati, Pier Luigi Canonico, Domenico Alvaro
Primary Biliary Cholangitis, previously known as Primary Biliary Cirrhosis, is a rare disease, which mainly affects women in their fifth to seventh decades of life. It is a chronic autoimmune disease characterized by a progressive damage of interlobular bile ducts leading to ductopenia, chronic cholestasis and bile acids retention. Even if the disease usually presents a long asymptomatic phase and a slow progression, in many patients it may progress faster toward cirrhosis and its complications. The 10year mortality is greater than in diseases such as human immunodeficiency virus/Hepatitis C Virus coinfection and breast cancer...
May 8, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28545931/validating-a-questionnaire-prehospital-preparedness-for-pediatric-trauma-patients
#11
Karin Bölenius, Christin Vestin, Britt-Inger Saveman, Lina Gyllencreutz
In recent decades, prehospital emergency care has undergone extensive development. Today, prehospital emergency nurses (PENs) are well trained and provide advanced care to patients of all ages. Caring for pediatric trauma patients is considered to be particularly demanding. However, in Sweden and internationally, there is a lack of research regarding PENs' preparedness for caring for pediatric trauma patients. OBJECTIVE: The development and testing of a questionnaire on self-reported preparedness among PENs caring for pediatric trauma patients in a prehospital emergency setting...
May 22, 2017: International Emergency Nursing
https://www.readbyqxmd.com/read/28545389/structural-insight-into-the-inactivation-of-mycobacterium-tuberculosis-non-classical-transpeptidase-ldtmt2-by-biapenem-and-tebipenem
#12
Mario A Bianchet, Ying H Pan, Leighanne A Brammer Basta, Harry Saavedra, Evan P Lloyd, Pankaj Kumar, Rohini Mattoo, Craig A Townsend, Gyanu Lamichhane
BACKGROUND: The carbapenem subclass of β-lactams is among the most potent antibiotics available today. Emerging evidence shows that, unlike other subclasses of β-lactams, carbapenems bind to and inhibit non-classical transpeptidases (L,D-transpeptidases) that generate 3 → 3 linkages in bacterial peptidoglycan. The carbapenems biapenem and tebipenem exhibit therapeutically valuable potencies against Mycobacterium tuberculosis (Mtb). RESULTS: Here, we report the X-ray crystal structures of Mtb L,D-transpeptidase-2 (LdtMt2) complexed with biapenem or tebipenem...
May 25, 2017: BMC Biochemistry
https://www.readbyqxmd.com/read/28545260/thermostabilization-of-the-uronate-dehydrogenase-from-agrobacterium-tumefaciens-by-semi-rational-design
#13
Teresa Roth, Barbara Beer, André Pick, Volker Sieber
Aldaric acids represent biobased 'top value-added chemicals' that have the potential to substitute petroleum-derived chemicals. Until today they are mostly produced from corresponding aldoses using strong chemical oxidizing agents. An environmentally friendly and more selective process could be achieved by using natural resources such as seaweed or pectin as raw material. These contain large amounts of uronic acids as major constituents such as glucuronic acid and galacturonic acid which can be converted into the corresponding aldaric acids via an enzyme-based oxidation using uronate dehydrogenase (Udh)...
December 2017: AMB Express
https://www.readbyqxmd.com/read/28545257/the-reactive-sulfur-species-concept-15-years-on
#14
REVIEW
Gregory I Giles, Muhammad Jawad Nasim, Wesam Ali, Claus Jacob
Fifteen years ago, in 2001, the concept of "Reactive Sulfur Species" or RSS was advocated as a working hypothesis. Since then various organic as well as inorganic RSS have attracted considerable interest and stimulated many new and often unexpected avenues in research and product development. During this time, it has become apparent that molecules with sulfur-containing functional groups are not just the passive "victims" of oxidative stress or simple conveyors of signals in cells, but can also be stressors in their own right, with pivotal roles in cellular function and homeostasis...
May 23, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/28544421/japan-s-115-year-trend-of-inter-prefectural-disparities-in-under-five-mortality
#15
Chie Nagata, Akinori Moriichi, Naho Morisaki, Ruoyan Gai-Tobe, Akira Ishiguro, Rintaro Mori
BACKGROUND: Child poverty is a growing, serious issue in Japan, where various social disparities are widening. Numerous reports have focused on the relationship between social inequity and health. However, few studies have assessed how the overall magnitude of disparities in child health has changed over the course of drastic social and economic transitions from 1899 to more recent times. In this study, we assessed the trend of the under-five mortality rate (U5MR) and its inter-prefectural disparities in Japan...
May 23, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/28544053/sickness-sin-and-discrimination-some-contemporary-challenges-for-uk-mental-health-nursing-practice-with-lesbian-gay-and-bisexual-lgb-people-and-communities
#16
Sarah Carr, Alfonso Pezzella
Curing 'homosexuality' or same-sex attraction has been a recurrent trope in Western psychiatry and mental health services for over a century. Despite the progress made in the UK with equality legislation, improvements in general social attitudes and the slowly increasing confidence of lesbian, gay and bisexual (LGB) individuals and communities (Carr, 2005), it appears to pose challenges for practice in the UK even today. This was recently highlighted in 2014 when the Department of Health requested the publication of a consensus statement from major UK mental health professional bodies outlining concern about and opposition to 'conversion' or 'reparative' therapy being offered to LGB people by practitioners (often working within a religious frame of reference) claiming to be able to 'cure' same-sex attraction (UK Council for Psychotherapy, 2014)...
May 25, 2017: Journal of Psychiatric and Mental Health Nursing
https://www.readbyqxmd.com/read/28543443/structural-review-of-ppar%C3%AE-in-complex-with-ligands-cartesian-and-dihedral-angle-principal-component-analyses-of-x-ray-crystallographic-data
#17
Åsmund Kaupang, Tuomo Laitinen, Antti Poso, Trond Vidar Hansen
Two decades of research into the ligand-dependent modulation of the activity of the peroxisome proliferator-activated receptor γ (PPARγ) have demonstrated the heterogeneous modes of action of PPARγ ligands, in terms of their interaction surfaces in the ligand-binding pocket, binding stoichiometry and ability to interact with functionally important parts of the receptor, through both direct and allosteric mechanisms. These findings signal the complex mechanistic bases of the distinct biological effects of different classes of PPARγ ligands...
May 24, 2017: Proteins
https://www.readbyqxmd.com/read/28542924/effects-of-mechanical-loading-on-human-mesenchymal-stem-cells-for-cartilage-tissue-engineering
#18
Jane Ru Choi, Kar Wey Yong, Jean Yu Choi
Today, articular cartilage damage is a major health problem, affecting people of all ages. The existing conventional articular cartilage repair techniques, such as autologous chondrocyte implantation (ACI), microfracture and mosaicplasty, have many shortcomings which negatively affect their clinical outcomes. Therefore, it is essential to develop an alternative and efficient articular repair technique that can address those shortcomings. Cartilage tissue engineering, which aims to create a tissue-engineered cartilage derived from human mesenchymal stem cells (MSCs), shows great promise for improving articular cartilage defect therapy...
May 19, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28542538/new-evidence-indicates-the-presence-of-barracuda-sphyraenidae-and-supports-a-tropical-marine-environment-in-the-miocene-of-madagascar
#19
Michael D Gottfried, Karen E Samonds, Summer A Ostrowski, Tsiory Harimalala Andrianavalona, Tolotra Niaina Ramihangihajason
Recent exploration of Miocene-age deposits at Nosy Makamby, a small island ~50 km southwest of Mahajanga city in northwestern Madagascar, has led to the recovery of a large sample [82] of isolated barracuda teeth (Sphyraena sp.). in a tropical marine fauna that also includes diverse marine invertebrates, chondrichthyans, bony fishes, turtles, crocodylians, and sirenians. Characteristically for barracudas, the teeth are labiolingually flattened and fang-like with a broadly triangular and blade-like acuminate outline and sharply edged but unserrated cutting margins...
2017: PloS One
https://www.readbyqxmd.com/read/28542239/projected-savings-through-public-health-voluntary-licences-of-hiv-drugs-negotiated-by-the-medicines-patent-pool-mpp
#20
Sandeep Juneja, Aastha Gupta, Suerie Moon, Stephen Resch
The Medicines Patent Pool (MPP) was established in 2010 to ensure timely access to low-cost generic versions of patented antiretroviral (ARV) medicines in low- and middle-income countries (LMICs) through the negotiation of voluntary licences with patent holders. While robust data on the savings generated by MPP and other major global public health initiatives is important, it is also difficult to quantify. In this study, we estimate the savings generated by licences negotiated by the MPP for ARV medicines to treat HIV/AIDS in LMICs for the period 2010-2028 and generate a cost-benefit ratio-based on people living with HIV (PLHIVs) in any new countries which gain access to an ARV due to MPP licences and the price differential between originator's tiered price and generics price, within the period where that ARV is patented...
2017: PloS One
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