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https://www.readbyqxmd.com/read/29036635/barbara-fish-and-a-short-history-of-the-neurodevelopmental-hypothesis-of-schizophrenia
#1
Assen Jablensky, Thomas F McNeil, Vera A Morgan
The neurodevelopmental hypothesis of schizophrenia has become a paradigm broadly accepted in today's research in schizophrenia and its spectrum. This article traces the historical development of the neurodevelopmental hypothesis of schizophrenia up until the time of its explicit formulation in 1987, by Weinberger and by Murray and Lewis, with a main focus on the seminal contribution of Barbara Fish to its conception and elaboration.
July 14, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/29036497/forecasting-residue-residue-contact-prediction-accuracy
#2
P P Wozniak, B M Konopka, J Xu, G Vriend, M Kotulska
Motivation: Apart from meta-predictors, most of today's methods for residue-residue contact prediction are based entirely on Direct Coupling Analysis (DCA) of correlated mutations in multiple sequence alignments (MSAs). These methods are on average ∼40% correct for the 100 strongest predicted contacts in each protein. The end-user who works on a single protein of interest will not know if predictions are either much more or much less correct than 40%, which is especially a problem if contacts are predicted to steer experimental research on that protein...
June 26, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29036142/standardized-target-specific-detectivity-metric-for-computational-imaging-systems
#3
Bradley L Preece, George Nehmetallah
Multifunctional cameras capable of performing a wide variety of nearly simultaneous imaging tasks are expected to play a major role in the near future. Computational imaging (CI) systems will serve as one of the main enabling technologies for multifunctional cameras, especially due to the abundance of low-cost, high-speed computational processing available today. An important aspect of these systems is to be able to quantify their performance with respect to specific imaging tasks. However, the non-traditional design of CI systems, both available and proposed, presents a considerable challenge to modeling, comparing, specifying, and measuring their performance...
September 1, 2017: Journal of the Optical Society of America. A, Optics, Image Science, and Vision
https://www.readbyqxmd.com/read/29035965/effectiveness-of-bedrails-in-preventing-falls-among-hospitalized-older-adults-a-systematic-review
#4
Paulo Marques, Carmen Queirós, João Apóstolo, Daniela Cardoso
BACKGROUND: Falls are a major problem today affecting adults of any age, but the elderly are a population that is more susceptible to falls. Falls are the leading cause of injury or death among older adults. Hospitalized older people are particularly vulnerable to falls. Falls cause direct injuries (minor injuries, severe wounds of the soft tissues and bone fractures) to patients and increased length of stay. The prevention of falls is commonly considered an indicator of the quality of care...
October 2017: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/29035646/electronic-health-record-portals-adoption-empirical-model-based-on-utaut2
#5
Jorge Tavares, Amélia Goulão, Tiago Oliveira
BACKGROUND: The future of healthcare delivery is becoming more citizen centered, as today's user is more active and better informed. Governmental institutions are promoting the deployment and use of online services such as Electronic Health Record (EHR) portals. This makes the adoption of EHR portals an important field to study and understand. OBJECTIVE: The aim of this study is to understand the factors that drive individuals to adopt EHR portals. METHODS: This study applies the extended unified theory of acceptance and usage technology (UTAUT2) to explain patients' individual adoption of EHR portals...
October 16, 2017: Informatics for Health & Social Care
https://www.readbyqxmd.com/read/29034941/selective-photocatalysis-of-lignin-inspired-chemicals-by-integrating-hybrid-nanocatalysis-in-microfluidic-reactors
#6
Juan Carlos Colmenares, Rajender S Varma, Vaishakh Nair
This tutorial review assesses the available and possible strategies for attaining higher selectivity and yield of value-added chemicals from lignin using nanocatalysts embedded in a photomicroreactor. The design of the photomicroreactor, the choice of photocatalysts and the techniques for assembling the catalysts in such confined spaces are crucial elements. Lignin, a predominant industrial byproduct and pollutant, has been recognized today as a rich reservoir for aromatic chemicals and a prominent resource...
October 16, 2017: Chemical Society Reviews
https://www.readbyqxmd.com/read/29034834/challenges-and-advances-in-gene-therapy-approaches-for-neurodegenerative-disorders
#7
Aneesh Donde, Philip C Wong, Liam L Chen
INTRODUCTION: The recent approval of Spinraza (nusinersen), an antisense oligonucleotide, by U.S. Food and Drug Administration to treat patients with spinal muscular atrophy, has reignited interests of researchers in designing and testing new gene therapy approaches to treat neurological disorders, in particular, to curb neurodegenerative diseases of the central nervous system which represent an everincreasing public health burden to today's society. CONCLUSION: This review highlights several key factors to be taken into consideration to design successful preclinical and clinical gene therapy experiments with respect to the vehicle of delivery and the route of administration to CNS-specific targets, with an additional focus on antisense oligonucleotide therapy and recent clinical trial developments...
October 13, 2017: Current Gene Therapy
https://www.readbyqxmd.com/read/29034477/hybrid-bodies-and-the-materiality-of-everyday-life-how-people-living-with-pacemakers-and-defibrillators-reinvent-everyday-routines-and-intimate-relations
#8
Nelly Oudshoorn
Technologies inside bodies pose new challenges in a technological culture. For people with pacemakers and defibrillators, activities such as passing security controls at airports, using electromagnetic machines, electrical domestic appliances and electronic devices, and even intimate contacts with their loved ones can turn into events where the proper functioning of their device may be at risk. Anticipation of potentially harmful events and situations thus becomes an important part of the choreography of everyday life...
October 15, 2017: Sociology of Health & Illness
https://www.readbyqxmd.com/read/29034240/dark-chocolate-opportunity-for-an-alliance-between-medical-science-and-the-food-industry
#9
Ivan M Petyaev, Yuriy K Bashmakov
Dark chocolate (DC) was originally introduced in human nutrition as a medicinal product consumable in a liquid form. Century-long efforts of food industry transformed this hardly appealing product into a valuable modern culinary delight with clear predominance of confectionery brands of DC on the market. However, current epidemiological data as well as multiple experimental and clinical observations reveal that DC consumption may have a profound effect on cardiovascular, central nervous systems, hemostasis, and lipid metabolism...
2017: Frontiers in Nutrition
https://www.readbyqxmd.com/read/29034191/pharmacological-properties-of-salvia-officinalis-and-its-components
#10
Ahmad Ghorbani, Mahdi Esmaeilizadeh
Salvia officinalis (Sage) is a plant in the family of Labiatae/Lamiaceae. It is native to Middle East and Mediterranean areas, but today has been naturalized throughout the world. In folk medicine, S. officinalis has been used for the treatment of different kinds of disorders including seizure, ulcers, gout, rheumatism, inflammation, dizziness, tremor, paralysis, diarrhea, and hyperglycemia. In recent years, this plant has been a subject of intensive studies to document its traditional use and to find new biological effects...
October 2017: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/29033604/chronic-pain-and-adult-hippocampal-neurogenesis-translational-implications-from-preclinical-studies
#11
Mariagrazia Grilli
Adult hippocampal neurogenesis (ahNG) occurs in the human brain. Adult generated neurons have been proposed to functionally contribute to relevant hippocampal functions such as learning and memory, mood regulation, and stress response. Learning, environmental enrichment, and physical exercise exert positive effects on ahNG. In parallel, these proneurogenic stimuli have been shown to ameliorate cognitive performance and/or depressive-like behavior in animal models. Conversely, aging, social isolation, and chronic stress exert negative effects on ahNG...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/29033394/diagnostic-biomarkers-for-lung-cancer-prevention
#12
Roberto Gasparri, Rosalia Romano, Giulia Sedda, Alessandro Borri, Francesco Petrella, Domenico Galetta, Monica Casiraghi, Lorenzo Spaggiari
Lung cancer is the leading cause of death for neoplasm. The lung cancer mortality is frequently associated with late diagnosis, therefore an early diagnosis is a key factor to significantly improve overall survival in high risk populations of asymptomatic patients. Conventional cancer screenings (low-dose computed tomography or chest x-ray) today offers early detection but are invasive and expensive. Up to date these studies evaluated the solid and topographic cancer structure and morphology. Today the concept of tumor has been remodeled and it has been defined as a disease that has its own genetic, biological and metabolic identity and on this new awareness we should base the new screening methods...
October 16, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/29033327/40-000-year-old-individual-from-asia-provides-insight-into-early-population-structure-in-eurasia
#13
Melinda A Yang, Xing Gao, Christoph Theunert, Haowen Tong, Ayinuer Aximu-Petri, Birgit Nickel, Montgomery Slatkin, Matthias Meyer, Svante Pääbo, Janet Kelso, Qiaomei Fu
By at least 45,000 years before present, anatomically modern humans had spread across Eurasia [1-3], but it is not well known how diverse these early populations were and whether they contributed substantially to later people or represent early modern human expansions into Eurasia that left no surviving descendants today. Analyses of genome-wide data from several ancient individuals from Western Eurasia and Siberia have shown that some of these individuals have relationships to present-day Europeans [4, 5] while others did not contribute to present-day Eurasian populations [3, 6]...
October 11, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/29033326/genetic-discontinuity-between-the-maritime-archaic-and-beothuk-populations-in-newfoundland-canada
#14
Ana T Duggan, Alison J T Harris, Stephanie Marciniak, Ingeborg Marshall, Melanie Kuch, Andrew Kitchen, Gabriel Renaud, John Southon, Ben Fuller, Janet Young, Stuart Fiedel, G Brian Golding, Vaughan Grimes, Hendrik Poinar
Situated at the furthest northeastern edge of Canada, the island of Newfoundland (approximately 110,000 km(2)) and Labrador (approximately 295,000 km(2)) today constitute a province characterized by abundant natural resources but low population density. Both landmasses were covered by the Laurentide ice sheet during the Last Glacial Maximum (18,000 years before present [YBP]); after the glacier retreated, ice patches remained on the island until ca. 9,000 calibrated (cal) YBP [1]. Nevertheless, indigenous peoples, whose ancestors had trekked some 5,000 km from the west coast, arrived approximately 10,000 cal YBP in Labrador and ca...
October 10, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/29032878/the-anterolateral-thigh-perforator-flap-in-pharyngo-esophageal-reconstruction
#15
M K De Frémicourt, S Temam, F Janot, F Kolb, Q Qassemyar
Today's customary techniques for pharyngo-esophageal reconstruction are jejunum and radial forearm free flaps. In this type of reconstruction, the jejunum flap is considered as the reference, but when its harvesting is not possible, the radial forearm flap is used. Since perforator flaps have begun to be developed, the anterolateral thigh flap (ATF) has become increasingly prominent in pharyngo-esophageal reconstruction. The aim of our study was to describe the use of the anterolateral perforator flap in pharyngo-esophageal reconstruction (indications, harvesting method, flap design) and to discuss its advantages and drawbacks as regards oral feeding and esophageal speech...
October 9, 2017: Annales de Chirurgie Plastique et Esthétique
https://www.readbyqxmd.com/read/29032757/an-evidence-based-review-of-medicinal-herbs-for-the-treatment-of-gastroesophageal-reflux-disease-gerd
#16
Ayda Hosseinkhani, Kamran Bagheri Lankarani, Abdolali Mohagheghzadeh, Chunlin Long, Mehdi Pasalar
BACKGROUND: Gastroesophageal reflux disease (GERD) is one of the most common diseases in society, affecting up to 40% of the population. It has major impact on the quality of life and a high burden on medical expenditure. In this work, herbs used by ancient Iranians to treat GERD have been introduced. METHODS: Different well-known Persian textbooks and recent electronic databases were searched to explore the treatment of GERD and the pharmacological mechanisms of the identified medicinal plants...
October 10, 2017: Current Drug Discovery Technologies
https://www.readbyqxmd.com/read/29032698/text-messages-promoting-mental-imagery-increase-self-reported-physical-activity-in-older-adults-a-randomized-controlled-study
#17
Nicolas Robin, Lucette Toussaint, Guillaume R Coudevylle, Shelly Ruart, Olivier Hue, Stéphane Sinnapah
This study tested whether text messages prompting adults over 50 years of age to perform mental imagery would increase Aerobic Physical Activity (APA) duration using a randomized parallel trial design. METHOD: Participants were assigned to an Imagery 1, Imagery 2 or Placebo group. For 4 weeks, each group was exposed to two conditions (morning text message vs. no morning text message). In the morning message condition, the Imagery groups received a text message with the instruction to mentally imagine performing an APA and the Placebo group received a placebo message...
October 14, 2017: Journal of Aging and Physical Activity
https://www.readbyqxmd.com/read/29032489/away-from-the-islands-diaspora-s-effects-on-native-hawaiian-elders-and-families-in-california
#18
Colette V Browne, Kathryn L Braun
Native Hawaiians, the indigenous people of Hawai'i, were once a healthy and hardy people. But today they are affected by varying social and health disparities that have led to poor social and health outcomes. Most of the research on Hawaiians in general and Native Hawaiian elders in particular has been conducted in Hawai'i, even though the Hawaiian Diaspora has resulted in 45% of this population residing in North America and Alaska. This qualitative study used key informant interviews and focus group methods to examine reasons for migration and perspectives on aging and caregiving in a sample of Native Hawaiian elders and family caregivers residing in Southern California...
October 14, 2017: Journal of Cross-cultural Gerontology
https://www.readbyqxmd.com/read/29032425/heterologous-expression-of-wheat-tarub1-gene-enhances-disease-resistance-in-arabidopsis-thaliana
#19
Yanlin Yang, Wenqiang Wang, Tian Xu, Na Liu, Honggang Wang, Deshun Feng
Expression of TaRUB1 gene in Arabidopsis thaliana elevates the level of disease-related genes in response to pathogen invasion through the accumulation of callose, necrotic cells, and the outbreak of ROS. Ubiquitin (Ub) and ubiquitin-like proteins are highly conserved in sequence and can covalently bind and modify many intracellular proteins which can be recognized and degraded by 26S proteasome. Post-translational modification of proteins has become a hot research spot today. In the previous study, a cDNA of related-to-ubiquitin protein belonged to ubiquitin-like proteins, whose spatial structure comprised Ub and NEDD8, was obtained from wheat SN6306 by suppression-subtractive hybridization and was named TaRUB1...
October 14, 2017: Plant Cell Reports
https://www.readbyqxmd.com/read/29032348/systems-proteomics-approaches-to-study-bacterial-pathogens-application-to-mycobacterium-tuberculosis
#20
REVIEW
Amir Banaei-Esfahani, Charlotte Nicod, Ruedi Aebersold, Ben C Collins
Significant developments and improvements in basic and clinical research notwithstanding, infectious diseases still claim at least 13 million lives annually. Classical research approaches have deciphered many molecular mechanisms underlying infection. Today it is increasingly recognized that multiple molecular mechanisms cooperate to constitute a complex system that is used by a given pathogen to interfere with the biochemical processes of the host. Therefore, systems-level approaches now complement the standard molecular biology techniques to investigate pathogens and their interactions with the human host...
October 12, 2017: Current Opinion in Microbiology
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