keyword
https://read.qxmd.com/read/37005129/rheumatological-adverse-events-secondary-to-immune-checkpoint-inhibitors
#1
REVIEW
María Cecilia Garbarino, Natalia Manzano, Osvaldo Messina, Marcelo Zylberman
The first experiences with a group of drugs called immune checkpoint inhibitors for the treatment of cancer were described in 2010. They are currently used in many tumours, with successful survival outcomes but a new profile of adverse events. This new spectrum of immune-mediated toxicities includes an exaggerated inflammatory response of T lymphocyte and the development of autoimmune diseases or similar pathologies. Of these, of particular note are the rheumatological toxicities. This review aims to alert internists and rheumatologists to their recognition and clinical management...
April 2023: Reumatología clinica
https://read.qxmd.com/read/36906390/peripheral-t-helper-subset-profiling-in-idiopathic-inflammatory-myositis-proof-of-concept
#2
JOURNAL ARTICLE
Anamika Kumari Anuja, Pankti Mehta, Mantabya Kumar Singh, Harshit Singh, Alok Nath, Zia Hashim, Ajmal Khan, Mansi Gupta, Durga P Misra, Vikas Agarwal, Latika Gupta
INTRODUCTION: There is a dearth of biomarkers in Idiopathic Inflammatory Myopathies (IIM) to recognize ongoing muscle inflammation and distinguish damage from activity. Since IIM is an autoantibody-mediated disease with tertiary lymphoid organogenesis reported in the diseased muscles, we aimed to study the peripheral blood T helper (Th) subset profiling as a plausible reflection of ongoing muscle inflammation. METHODS: Fifty-six patients of IIM were compared with 21 healthy controls (HC) and 18 patients with sarcoidosis...
March 2023: Reumatología clinica
https://read.qxmd.com/read/36867574/fibrodysplasia-ossificans-progressiva-in-a-3-year-old-female-patient
#3
JOURNAL ARTICLE
Cecilia Moreira, Gabriel Dapueto, Gabriel Peluffo, Alejandra Vomero, Alejandra Tapié, Soledad Rodríguez, Victor Raggio, Rodrigo Suárez, Gustavo Giachetto, Loreley García
BACKGROUND: Fibrodysplasia ossificans progressiva (FOP) is a rare autosomal dominant disease affecting connective tissue, primarily caused by de novo mutations of the ACVR1 gene. FOP is a disease with congenital malformations of the toes and heterotopic ossification in characteristic patterns that progresses with flare-ups and remissions. Cumulative damage results in disability and, eventually, death. This report aimed to describe a case of FOP to highlight the importance of early diagnosis of this rare condition...
2023: Boletín Médico del Hospital Infantil de México
https://read.qxmd.com/read/36842785/imaging-palpable-tumors-in-pediatrics-part-2
#4
JOURNAL ARTICLE
D Llanos, I de la Pedraja, L Campos, J Armijo, L F Ávila
Palpable tumors in children are a common reason for consulting a radiologist. The origin of these lesions varies widely, and although they are common, classic radiology books do not cover some of them. This series of two articles aims to review the clinical and radiological characteristics of a selection of palpable tumors in children that radiologists need to be familiar with.
2023: Radiología
https://read.qxmd.com/read/36710163/-streptococcus-canis-as-a-cause-of-osteosynthesis-material-and-myositis
#5
Domingo Fernández Vecilla, Fernando Díez Renovales, José Luis Díaz de Tuesta Del Arco
No abstract text is available yet for this article.
January 27, 2023: Enfermedades infecciosas y microbiologia clinica
https://read.qxmd.com/read/35568443/myositis-associated-interstitial-lung-disease-clinical-characteristics-and-factors-related-to-pulmonary-function-improvement-a-latin-american-multicenter-cohort-study
#6
MULTICENTER STUDY
María Laura Alberti, Verónica Wolff, Felipe Reyes, Ernesto Juárez-León, Leandro Fassola, Gabriel Carballo, Ivette Buendía-Roldán, Jorge Rojas-Serrano, Fabián Caro, Matías Florenzano, Francisco Paulín
BACKGROUND AND OBJECTIVES: ILD patients can be positive to highly specific autoantibodies of connective tissue diseases (CTD). Among them stand out myositis-specific and associated autoantibodies (MSA/MAA). There is limited knowledge about treatment response and prognosis of ILD patients positive to MSA/MAA (MSA/MAA-ILD). Our aim was to describe clinical, radiological and pulmonary function (PF) of MSA/MAA-ILD Latin-American patients and risk factors associated to PF at onset and long term follow up...
May 2022: Reumatología clinica
https://read.qxmd.com/read/35338824/-bartonella-henselae-myositis-case-report-in-an-adolescent
#7
Pablo Gómez Garrido, M Lourdes Calleja Gero, Juan C López Robledillo, Celia Martín Villaescusa
Infectious myositis, whether viral or bacterial, is frequent in pediatric age. It causes muscle pain and weakness, associated with fever and general malaise. One cause is Bartonella henselae, responsible for cat scratch disease, which sometimes causes systemic symptoms. We report the case of an adolescent who came to the emergency room with intense myalgia, malaise, weight loss and splenomegaly. Blood tests showed high inflammatory markers. She had been in touch with a cat. Studies were carried out including: lower limbs MRI suggestive of bilateral inflammatory myositis, abdominal MRI with three previously undetected splenic lesions and dilated fundus examination that showed possible retinal arterial occlusion or vasculitis...
April 2022: Archivos Argentinos de Pediatría
https://read.qxmd.com/read/34400117/myo-spain-spanish-registry-of-patients-with-idiopathic-inflammatory-myopathy-methodology
#8
MULTICENTER STUDY
Tatiana Cobo-Ibáñez, Carlos Sánchez-Piedra, Laura Nuño-Nuño, Iván Castellví, Irene Carrión-Barberà, Fredeswinda Romero-Bueno, Javier Narváez, Ernesto Trallero-Araguás, Eva Tomero, María Esther Ruiz-Lucea, Carmen Larena, Carmen Carrasco Cubero, Vega Jovaní, Carmen Barbadillo, Francisca Sivera, Joaquín Belzunegui, Ana Pérez Gómez, Alejandro Gómez Gómez, Esmeralda Delgado-Frías, José María Pego-Reigosa, Beatriz Joven, Mónica Ibáñez, Olga Martínez-González, Alberto Ruiz-Román, Jordi Camins, Rafaela Ortega-Castro, Pilar Trenor Larra, Marina Rodríguez López, Mercedes Freire, Patricia Alcocer, Susana Holgado, Iñigo Rúa-Figueroa, Nuria Lozano, Julia Martínez-Barrio
OBJECTIVES: To describe the methods of the Spanish Registry of patients with idiopathic inflammatory myopathy (IIM) (Myo-Spain), as well as its strengths and limitations. The main objective of the project is to analyse the evolution and clinical management of a cohort of patients with IIM. METHODS: Observational, longitudinal, ambispective and multicentre study of a cohort of patients with IIM seen in rheumatology units in Spain. All patients with a diagnosis of IMM will be included in the regular follow-up of the participating centres, regardless of age on initiation of the process...
May 2022: Reumatología clinica
https://read.qxmd.com/read/34137710/sarcoid-like-granulomatous-myositis-associated-hypercalcemia-an-infrequent-case-to-consider
#9
JOURNAL ARTICLE
Thomas Uslar, Roberto Olmos, Jaime Godoy-Santin, Patricio Mellado, Gilberto Gonzalez
PTH-independent hypercalcemia due to granulomatous disease is well-documented and sarcoidosis is the most characteristic disease, although there are others. We describe a case of sarcoid-like granulomatous myositis. An 87-year-old man was referred with tetraparesis and hypercalcemia (albumin-corrected calcium of 13.4 mg/dl) following a trip to the Caribbean. The evaluation showed a suppressed PTH, 25-hydroxy vitamin D of 7.5 ng/ml, 18F-FDG PET/CT showed markedly increased uptake in intercostal, back, shoulder, buttock and thigh muscles and a deltoid biopsy confirmed extensive granulomatous myositis...
2021: Medicina
https://read.qxmd.com/read/33867271/myo-spain-spanish-registry-of-patients-with-idiopathic-inflammatory-myopathy-methodology
#10
JOURNAL ARTICLE
Tatiana Cobo-Ibáñez, Carlos Sánchez-Piedra, Laura Nuño-Nuño, Iván Castellví, Irene Carrión-Barberà, Fredeswinda Romero-Bueno, Javier Narváez, Ernesto Trallero-Araguás, Eva Tomero, María Esther Ruiz-Lucea, Carmen Larena, Carmen Carrasco Cubero, Vega Jovaní, Carmen Barbadillo, Francisca Sivera, Joaquín Belzunegui, Ana Pérez Gómez, Alejandro Gómez Gómez, Esmeralda Delgado-Frías, José María Pego-Reigosa, Beatriz Joven, Mónica Ibáñez, Olga Martínez-González, Alberto Ruiz-Román, Jordi Camins, Rafaela Ortega-Castro, Pilar Trenor Larra, Marina Rodríguez López, Mercedes Freire, Patricia Alcocer, Susana Holgado, Iñigo Rúa-Figueroa, Nuria Lozano, Julia Martínez-Barrio
OBJECTIVES: To describe the methods of the Spanish Registry of patients with idiopathic inflammatory myopathy (IIM) (Myo-Spain), as well as its strengths and limitations. The main objective of the project is to analyse the evolution and clinical management of a cohort of patients with IIM. METHODS: Observational, longitudinal, ambispective and multicentre study of a cohort of patients with IIM seen in rheumatology units in Spain. All patients with a diagnosis of IMM will be included in the regular follow-up of the participating centres, regardless of age on initiation of the process...
April 15, 2021: Reumatología clinica
https://read.qxmd.com/read/33861830/-orbital-myositis-a-cause-of-pediatric-painful-ophthalmoplegia
#11
JOURNAL ARTICLE
Luisa María Parra-Rodas, Elizabeth Parra-Rodas, María José Jiménez-Villegas, Yulieth Cartagena-Agudelo, Dagoberto Cabrera-Hemer
INTRODUCTION: Orbital myositis (OM) is a serious inflammation of extraocular muscles with unknown etiology. Pe diatric presentation is rare and often affects more than one individual in a family, suggesting a genetic predisposition. OBJECTIVE: To describe a pediatric case of orbital myositis, its clinical characteristics, and the usefulness of MRI for confirming the diagnosis. CLINICAL CASE: A 13-year-old female patient presenting with acute headache, right periorbital pain, exacerbated by eye movements, and blurred vision...
December 2020: Revista Chilena de Pediatría
https://read.qxmd.com/read/33674248/-acute-haematogenous-osteomyelitis-in-lisbon-an-unexpectedly-high-association-with-myositis-and-arthritis
#12
JOURNAL ARTICLE
Catarina Gouveia, Joana Branco, Susana Norte, Joana Arcangelo, Pedro Alves, Margarida Pinto, Delfin Tavares
INTRODUCTION: Despite the current trend towards less aggressive therapeutic approaches, acute haematogenous osteomyelitis (AHO) continues to be a challenge and is associated with significant morbidity worldwide. Our aim was to determine if 80% compliance with current protocol was achieved, identify complications and associated risk factors and analyse trends in aetiology and management of AHO in children. METHODS: We conducted a longitudinal, observational, single-centre study in patients with AHO aged less than 18 years admitted to a paediatric hospital, between 2008 and 2018, divided into 2 cohorts (before and after 2014)...
March 2, 2021: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://read.qxmd.com/read/33602594/myositis-associated-interstitial-lung-disease-clinical-characteristics-and-factors-related-to-pulmonary-function-improvement-a-latin-american-multicenter-cohort-study
#13
JOURNAL ARTICLE
María Laura Alberti, Verónica Wolff, Felipe Reyes, Ernesto Juárez-León, Leandro Fassola, Gabriel Carballo, Ivette Buendía-Roldán, Jorge Rojas-Serrano, Fabián Caro, Matías Florenzano, Francisco Paulín
BACKGROUND AND OBJECTIVES: ILD patients can be positive to highly specific autoantibodies of connective tissue diseases (CTD). Among them stand out myositis-specific and associated autoantibodies (MSA/MAA). There is limited knowledge about treatment response and prognosis of ILD patients positive to MSA/MAA (MSA/MAA-ILD). Our aim was to describe clinical, radiological and pulmonary function (PF) of MSA/MAA-ILD Latin-American patients and risk factors associated to PF at onset and long term follow up...
February 15, 2021: Reumatología clinica
https://read.qxmd.com/read/22081461/an-unusual-case-of-lumbar-paravertebral-miositis-ossificans-mimicking-muscular-skeletal-tumor
#14
JOURNAL ARTICLE
C Zoccali, G Chichierchia, R Covello
Several lesions have clinical and radiological characteristics mimicking muscular skeletal tumor. Myositis ossificans usually presents a typical pattern making biopsy unnecessary; nevertheless, in rare cases, neoplasm must be ruled out. Biopsy is often sufficient to allow a diagnosis and a correct related treatment, but, unfortunately, sometimes it may lead to erroneous treatment. We report an unusual case of a lumbar paravertebral mass that had an MRI aspect similar to a chondrosarcoma, a histology pattern based on biopsy compatible with neurinoma and a definitive diagnosis of myosistis ossificans...
December 2013: Musculoskeletal Surgery
https://read.qxmd.com/read/21794447/-antisynthetase-syndrome-without-muscle-involvement
#15
JOURNAL ARTICLE
Enrique Júdez Navarro, Myriam Martínez Carretero, Gonzalo Fidel Martínez Jiménez
Antisynthetase syndrome is a well defined syndrome characterized by the presence of interstitial lung disease in association with arthritis, miositis, mechanic's hands and Ruynaud's phenomenon in the presence of antisynthetase antibodies, especially Ac anti-Jo1. We described the case of a 68-year-old man with this syndrome in the absence of inflammatory muscle disease.
November 2007: Reumatología Clinica
https://read.qxmd.com/read/16462964/-invasive-infections-caused-by-haemophilus-influenzae-type-b-after-the-institution-of-the-conjugated-vaccine-on-the-expanded-programm-on-immunization-in-chile
#16
JOURNAL ARTICLE
Pablo Cruces R, Alejandro Donoso F, Jorge Camacho A, Marcela Llorente H
After almost a decade since the introduction of Haemophilus influenzae type b (Hib) conjugate vaccines in Chile (in a 2-4-6 month schedule), Hib invasive infections have dramatically decreased, albeit they remain to occasionally produce disease in pediatric patients. We report our experience with children whom developed Hib invasive disease in children since 2000 to 2004. Medical records of children with Hib were reviewed in order to describe the epidemiology, main clinical and laboratory findings, management and complications...
March 2006: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
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