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https://www.readbyqxmd.com/read/28544989/impact-of-mediolateral-episiotomy-on-incidence-of-obstetrical-anal-sphincter-injury-diagnosed-by-endoanal-ultrasound
#1
Kristina Drusany Staric, Adolf Lukanovic, Petra Petrocnik, Vita Zacesta, Corrado Cescon, Miha Lucovnik
OBJECTIVE: to examine potential association between mediolateral episiotomy and reduced incidence of obstetrical anal sphincter injuries (OASIS) diagnosed by endoanal ultrasound. DESIGN: prospective cohort study. SETTING: tertiary referral university hospital. PARTICIPANTS: sixty nulliparous women at 28-33 weeks of gestation with singleton pregnancies were included between 2010 and 2012. MEASUREMENTS AND FINDINGS: participants were examined with endoanal ultrasound at 28-33 weeks gestation and at 6-7 weeks post-partum...
May 18, 2017: Midwifery
https://www.readbyqxmd.com/read/28544499/preventing-progression-from-gestational-diabetes-mellitus-to-diabetes-a-thought-filled-review
#2
REVIEW
Michal Kasher-Meron, Martin M Grajower
Women with a history of gestational diabetes (GDM) are at high risk for developing type 2 diabetes mellitus (T2DM). In studies with long periods of follow up, diabetes incidence of up to 70% has been reported. The appropriate follow up of women following a pregnancy complicated by GDM has not been studied. Published guidelines recommend that obstetrician/gynecologists, who are often the de facto primary care physicians for these otherwise healthy young women, make glucose monitoring in the post-partum period part of their annual examinations...
May 19, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28544232/peripartum-cytokine-flares-in-a-multiethnic-cohort-of-chronic-hepatitis-b-carriers-does-not-correlate-with-hepatitis-b-virus-suppression-or-increased-risk-of-liver-disease
#3
Shivali S Joshi, Daniel Wong, Eliana Castillo, Mark G Swain, Carla S Coffin
PROBLEM: In chronic hepatitis B (CHB) carriers, alanine transaminase (ALT) flares are common in the peripartum period. There are limited data on immunological changes of pregnancy in CHB. We hypothesize that in pregnant CHB carriers, the Th1/Th2 cytokine ratio is altered resulting in changes in biochemical/virological and liver fibrosis markers. STUDY METHODS: Serum from 38 pregnant/post-partum CHB carriers (median age 32 years, 53% Asian, 8 HBeAg(+) ) was tested for HBV DNA, quantitative HBV surface antigen, ALT and liver fibrosis by transient elastography (TE)...
May 19, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28542790/transition-to-motherhood-in-women-with-an-infant-with-special-care-needs
#4
O Korukcu, A Deliktaş, K Kukulu
BACKGROUND: Mothers of infants with special care needs experience multiple transitions, as their babies are diagnosed with congenital anomalies and hospitalized during their transition to motherhood. AIM: To examine the transition to motherhood in mothers of infants with special care needs, under the guidance of Meleis's Theory of Transition. METHODS: A descriptive qualitative approach was used. We followed a semi-structured form prepared in accordance with Meleis's Theory of Transition's concepts...
May 25, 2017: International Nursing Review
https://www.readbyqxmd.com/read/28536980/a-retrospective-cohort-study-of-obstetric-outcomes-in-opioid-dependent-women-treated-with-implant-naltrexone-oral-methadone-or-sublingual-buprenorphine-and-non-dependent-controls
#5
Erin Kelty, Gary Hulse
BACKGROUND: Opioid pharmacotherapies play an important role in the treatment of opioid-dependent women; however, very little is known about the safety of naltrexone in pregnant patients. OBJECTIVE: This study examined the obstetric health of opioid-dependent women who were treated with implant naltrexone during pregnancy, and compared them with women treated with methadone and/or buprenorphine and a cohort of non-opioid-dependent controls. METHODS: Women treated with implant naltrexone, oral methadone or sublingual buprenorphine between 2001 and 2010, along with a cohort of age-matched controls, were linked with records from midwives, hospital and emergency departments (EDs) and the death registry to identify pregnancy and health events that occurred during pregnancy and in the post-partum period...
May 23, 2017: Drugs
https://www.readbyqxmd.com/read/28536510/influence-of-pre-reproductive-maternal-enrichment-on-coping-response-to-stress-and-expression-of-c-fos-and-glucocorticoid-receptors-in-adolescent-offspring
#6
Debora Cutuli, Erica Berretta, Greta Pasqualini, Paola De Bartolo, Paola Caporali, Daniela Laricchiuta, Patricia Sampedro-Piquero, Francesca Gelfo, Matteo Pesoli, Francesca Foti, Azucena Begega, Laura Petrosini
Environmental enrichment (EE) is an experimental setting broadly used for investigating the effects of complex social, cognitive, and sensorimotor stimulations on brain structure and function. Recent studies point out that parental EE experience, even occurring in the pre-reproductive phase, affects neural development and behavioral trajectories of the offspring. In the present study we investigated the influences of pre-reproductive EE of female rats on maternal behavior and adolescent male offspring's coping response to an inescapable stressful situation after chronic social isolation...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/28532844/effects-of-d-cloprostenol-on-different-layers-and-regions-of-the-bovine-uterus-during-the-follicular-and-luteal-phases
#7
M Piccinno, R L Sciorsci, V Masciopinto, M De Rosa, A Rizzo
INTRODUCTION: D-cloprostenol is a synthetic PGF2α, commonly used in bovine reproduction, that increases myometral contractility. However, little is known regarding its contractile behaviour and how it depends on the reproductive state and uterine topography (regions and muscular layers). HYPOTHESIS AND OBJECTIVES: These aspects would affect the action of d-cloprostenol on the uterus. Therefore, we hypothesize a possible use of this drug at the time of artificial insemination, to improve conception rates and, in the post-partum, in order to accelerate uterine involution in dairy cattle...
July 1, 2017: Theriogenology
https://www.readbyqxmd.com/read/28527083/shared-mechanisms-of-epilepsy-migraine-and-affective-disorders
#8
Davide Zarcone, Simona Corbetta
Since the nineteenth century several clinical features have been observed in common between migraine and epilepsy (such as episodic attacks, triggering factors, presence of aura, frequent familiarity), but only in recent years researchers have really engaged in finding a common pathogenic mechanism. From studies of disease incidence, we understand how either migraine among patients with epilepsy or epilepsy among migraine patients are more frequent than in the general population. This association may result from a direct causality, by the same environmental risk factors and/or by a common genetic susceptibility...
May 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28526027/description-of-inter-institutional-referrals-after-admission-for-labor-and-delivery-a-prospective-population-based-cohort-study-in-rural-maharashtra-india
#9
Archana B Patel, Amber Abhijeet Prakash, Camille Raynes-Greenow, Yamini V Pusdekar, Patricia L Hibberd
BACKGROUND: In 2008, the Indian government introduced financial assistance to encourage health facility deliveries. Facility births have increased, but maternal and neonatal morbidity and mortality have not decreased raising questions about the quality of care provided in facilities and access to a quality referral system. We evaluated the potential role of inter-institutional transfers of women admitted for labor and delivery on adverse maternal and neonatal outcomes in an ongoing prospective, population-based Maternal and Newborn Health Registry in Central India...
May 19, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28507834/clinical-and-radiological-improvement-following-ozone-disc-nucleolysis-a-case-report
#10
Sharad Ghatge, Pranav D Modi, Dhaval B Modi
The results of traditional open surgery for herniated intervertebral disc are often limited by complications and failed back surgery syndrome (FBSS). Over the past few decades, a considerable amount of research has been done in the field of minimally invasive procedures as a treatment option for herniated intervertebral disc disease. Ozone disc nucleolysis is one such procedure which has results equal to or better than traditional surgery with virtually no complications. A 27-year-old post-partum female presented to the clinic with acute onset of severe lower back pain radiating to the left lower limb for one month...
April 13, 2017: Curēus
https://www.readbyqxmd.com/read/28503319/an-unexpected-delivery-pregnancy-experience-of-a-paraplegic-lady
#11
Nadia M Mustafah, Noriani A Bakar, Aishah A Fauzi, Norhayati Hussein
INTRODUCTION: Spinal cord injury (SCI) has increased over the years, and so has the survival. Women with SCI remain fertile and have equal chance of pregnancy. CASE PRESENTATION: We described a case of a 29-year-old lady with traumatic spinal cord injury (SCI) resultant with paraplegia in 2008, who conceived naturally 2 years after the injury. She only had her antenatal check-up at a low-risk antenatal center throughout her pregnancy and was not referred to specialized obstetric care...
2017: Spinal Cord Series and Cases
https://www.readbyqxmd.com/read/28502190/two-rare-risk-factors-for-post-partum-haemorrhage-a-case-report-of-a-carrier-of-severe-haemophilia-a-with-a-uterine-arteriovenous-malformation
#12
Gemma L Malin, Gillian Swallow, Jane Rutherford
No abstract text is available yet for this article.
May 14, 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28500083/hepatic-thyroid-signaling-of-heat-stressed-late-pregnant-and-early-lactating-cows
#13
Joachim Weitzel, Thorsten Viergutz, Dirk Albrecht, Rupert M Bruckmaier, Marion Schmicke, Armin Tuchscherer, Franziska Koch, Björn Kuhla
During the transition between late gestation and early lactation dairy cows experience severe metabolic stress due to the high energy and nutrient requirements of the fetus and the mammary gland. Additional thermal stress as occurring with rising temperatures during the ongoing climate change has further adverse implications on energy intake, metabolism and welfare. The thyroid hormone (TH)-mediated cellular signaling has a pivotal role in regulation of body temperature, energy intake and metabolic adaptation to heat...
May 12, 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28496535/spontaneous-rupture-of-a-choledochal-cyst-during-post-partum-a-rare-presentation
#14
Ashish Gupta, Karikal Chakaravarthi, Lileswar Kaman
With the advent of newer radiological investigations, choledochal cysts are being diagnosed more often in present era. These cysts are commonly diagnosed in early childhood and infancy, although some go undetected to be diagnosed in adulthood. These malformations are associated with multiple complications like cholangitis, jaundice, pancreatitis, rupture or even malignancy. Here we describe a post partum female, who was diagnosed to have choledochal cyst during sixth month of pregnancy. She presented with obstructive jaundice in cholangitis and was subjected to endoscopic retrograde cholangiopancreatography (ERCP) with stenting...
April 2017: Gastroenterology Research
https://www.readbyqxmd.com/read/28494018/pathogenic-outcome-following-experimental-infection-of-sheep-with-chlamydia-abortus-variant-strains-llg-and-pos
#15
Morag Livingstone, Nicholas Wheelhouse, Hannah Ensor, Mara Rocchi, Stephen Maley, Kevin Aitchison, Sean Wattegedera, Kim Wilson, Michelle Sait, Victoria Siarkou, Evangelia Vretou, Gary Entrican, Mark Dagleish, David Longbottom
This study investigated the pathogenesis of two variant strains (LLG and POS) of Chlamydia abortus, in comparison to a typical wild-type strain (S26/3) which is known to be responsible for late term abortion in small ruminants. Challenge with the three strains at mid-gestation resulted in similar pregnancy outcomes, with abortion occurring in approximately 50-60% of ewes with the mean gestational lengths also being similar. However, differences were observed in the severity of placental pathology, with infection appearing milder for strain LLG, which was reflected in the lower number of organisms shed in vaginal swabs post-partum and less gross pathology and organisms present in placental smears...
2017: PloS One
https://www.readbyqxmd.com/read/28489856/randomized-trial-of-stopping-or-continuing-art-among-postpartum-women-with-pre-art-cd4-%C3%A2-400-cells-mm3
#16
Judith S Currier, Paula Britto, Risa M Hoffman, Sean Brummel, Gaerolwe Masheto, Esau Joao, Breno Santos, Linda Aurpibul, Marcelo Losso, Marie F Pierre, Adriana Weinberg, Devasena Gnanashanmugam, Nahida Chakhtoura, Karin Klingman, Renee Browning, Anne Coletti, Lynne Mofenson, David Shapiro, Jose Pilotto
BACKGROUND: Health benefits of postpartum antiretroviral therapy (ART) for human immunodeficiency virus (HIV) positive women with high CD4+ T-counts have not been assessed in randomized trials. METHODS: Asymptomatic, HIV-positive, non-breastfeeding women with pre-ART CD4+ T-cell counts ≥ 400 cells/mm3 started on ART during pregnancy were randomized up to 42 days after delivery to continue or discontinue ART. Lopinavir/ritonavir plus tenofovir/emtricitabine was the preferred ART regimen...
2017: PloS One
https://www.readbyqxmd.com/read/28488736/inhibition-of-mtor-pathway-decreases-the-expression-of-pre-meiotic-and-meiotic-markers-throughout-postnatal-development-and-in-adult-testes-in-mice
#17
P Sahin, N E Gungor-Ordueri, C Celik-Ozenci
Rapamycin (mTOR inhibitor) has been reported to have negative effect on human male gonadal function. Previously, we showed that mTOR signalling molecules are expressed during early spermatogenesis in mice. The objective of this study was to investigate the role of mTOR signalling in meiosis both during the first wave of spermatogenesis and also during adult spermatogenesis. Day 5 post-partum mice were administered rapamycin and retinoic acid (RA; a Stra8 activator), and expression of p-p70S6K and Stra8 proteins was evaluated...
May 10, 2017: Andrologia
https://www.readbyqxmd.com/read/28486633/development-of-a-murine-vertical-transmission-model-for-toxoplasma-gondii-oocyst-infection-and-studies-on-the-efficacy-of-bumped-kinase-inhibitor-bki-1294-and-the-naphthoquinone-buparvaquone-against-congenital-toxoplasmosis
#18
Joachim Müller, Adriana Aguado-Martínez, Luis-Miguel Ortega-Mora, Javier Moreno-Gonzalo, Ignacio Ferre, Matthew A Hulverson, Ryan Choi, Molly C McCloskey, Lynn K Barrett, Dustin J Maly, Kayode K Ojo, Wes Van Voorhis, Andrew Hemphill
Objectives: Establishment of a mouse model for congenital toxoplasmosis based on oral infection with oocysts from Toxoplasma gondii ME49 and its application for investigating chemotherapeutic options against congenital toxoplasmosis. Methods: CD1 mice were mated, orally infected with 5, 25, 100, 500 or 2000 oocysts and monitored for clinical signs and survival of dams and pups until 4 weeks post partum . The parasite burden in infected mice was quantified by real-time PCR in lungs, brains and, in the case of surviving pups, also in eyes...
May 9, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28482923/transplacental-transmission-of-theileria-orientalis-occurs-at-a-low-rate-in-field-affected-cattle-infection-in-utero-does-not-appear-to-be-a-major-cause-of-abortion
#19
Emma Swilks, Shayne A Fell, Jade F Hammer, Narelle Sales, Gaye L Krebs, Cheryl Jenkins
BACKGROUND: Bovine theileriosis, caused by the haemoprotozoan Theileria orientalis, is an emerging disease in East Asia and Australasia. Previous studies have demonstrated transplacental transmission of various Theileria spp. but molecular confirmation of transplacental transmission of T. orientalis has never been confirmed in the field. In this study, cow-calf (< 48 h old) pairs were sampled across 3 herds; opportunistic samples from aborted foetuses or stillborn calves were also examined...
May 8, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28481028/preservation-of-chromosomal-integrity-in-murine-spermatozoa-derived-from-gonocytes-and-spermatogonial-stem-cells-surviving-prenatal-and-postnatal-exposure-to-%C3%AE-rays-in-mice
#20
Hiroyuki Watanabe, Atsushi Kohda, Jun-Ichiro Komura, Hiroyuki Tateno
Pre- and postnatal male mice were acutely (659 - 690 mGy/min) and continuously (0.303 mGy/min) exposed to 2 Gy γ-rays to evaluate spermatogenic potential and chromosome damage in their germ cells as adults. Acute irradiation on Days 15.5, 16.5, and 17.5 post-coitus affected testicular development, as a result of massive quiescent gonocyte loss; the majority of the seminiferous tubules in these testes were devoid of germ cells. Acute irradiation on Days 18.5 and 19.5 post-coitus had less effect on testicular development and spermatogenesis, even though germ cells were quiescent gonocytes on these days...
May 8, 2017: Molecular Reproduction and Development
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