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Sam Jacob, Donald J Deyo, Robert A Cox, Daniel L Traber, David N Herndon, Hal K Hawkins
The effects of neutral endopeptidase (NEP) in acute inflammation in the lung were studied using a newly developed murine model of smoke and burn (SB) injury. C57BL/6 mice were pretreated with an i.v. dose of a specific NEP antagonist CGS-24592 (10 mg/Kg) 1 h prior to SB injury (n = 5-8/group). Mice were anesthetized with i.p. ketamine/xylazine, intubated, and exposed to cooled cotton smoke (2 x 30 s). After s.c. injection of 1 ml 0.9% saline, each received a 40% total body surface area (TBSA) flame burn. Buprenorphene (2 mg/kg) was given i...
March 2009: Toxicology Mechanisms and Methods
A Iruín, I Aizpurua, J Ruiz de Apodaka, E Zapiraín, A Aizpuru
The implementation of the methadone maintenance treatment programs marked a true milestone in the treatment of those opioid-dependent patients who had met with failure in the different treatment alternatives which had existed up until that time. The purpose of this paper is that of reviewing the scientific evidence regarding the advantages and drawbacks involved in the different drug-related alternatives for use in lieu of methadone for opioid-dependent individuals. To pinpoint the clinical tests conducted, searches were run on Medline (1966-1999), the IDIS (Iowa Drug Information System (1985-1999) and the Cochrane Library 1999 clinical testing database (3rd quarter)...
May 2001: Revista Española de Salud Pública
E Tønnesen, H Mickley, N Grunnet
Natural killer (NK) cell activity of peripheral blood mononuclear cells was measured against K-562 target cells in a 51Cr release assay in eight patients undergoing total hip replacement surgery. Eight consecutive blood samples were taken from each patient. A significant increase of NK cell activity was observed after premedication with diazepam per os. The activity increased further during a combined anaesthesia (thiopentone + N2O + O2 + buprenorphene + pancuronium) and remained increased during surgery. Postoperatively, NK cell activity fell and remained depressed for a period of at least 5 days...
June 1983: Acta Anaesthesiologica Scandinavica
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