keyword
MENU ▼
Read by QxMD icon Read
search

Spinal cord protection

keyword
https://www.readbyqxmd.com/read/29679457/burst-spinal-cord-stimulation-in-peripherally-injured-chronic-neuropathic-rats-a-delayed-effect
#1
Koen P V Meuwissen, Jianwen Wendy Gu, Tianhe C Zhang, Elbert A J Joosten
OBJECTIVE: Two well-known spinal cord stimulation (SCS) paradigms, Conventional (Con) and Burst-SCS, are hypothesized to exert their anti-nociceptive effects through different stimulation-induced mechanisms. We studied the course of the behavioral anti-nociceptive effect during 60 minutes of SCS and 30 minutes post SCS, in a rat model of chronic neuropathic pain. MATERIAL AND METHODS: Animals received a unilateral partial sciatic nerve ligation, after which they were implanted with quadripolar electrodes into the epidural space at vertebral level T13 (n=43 rats)...
April 20, 2018: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/29674624/brain-and-spinal-cord-injury-repair-by-implantation-of-human-neural-progenitor-cells-seeded-onto-polymer-scaffolds
#2
Jeong Eun Shin, Kwangsoo Jung, Miri Kim, Kyujin Hwang, Haejin Lee, Il-Sun Kim, Bae Hwan Lee, Il-Shin Lee, Kook In Park
Hypoxic-ischemic (HI) brain injury and spinal cord injury (SCI) lead to extensive tissue loss and axonal degeneration. The combined application of the polymer scaffold and neural progenitor cells (NPCs) has been reported to enhance neural repair, protection and regeneration through multiple modes of action following neural injury. This study investigated the reparative ability and therapeutic potentials of biological bridges composed of human fetal brain-derived NPCs seeded upon poly(glycolic acid)-based scaffold implanted into the infarction cavity of a neonatal HI brain injury or the hemisection cavity in an adult SCI...
April 20, 2018: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/29664452/protective-role-of-astragalus-injection-in-spinal-cord-ischemia-reperfusion-injury-in-rats
#3
Liya Zhou, Zhenfei Song, Liwen Zhou, Yongchi Qiu, Nan Hu, Yong Hu, Xingming Hu
OBJECTIVE: To investigate the neuroprotective effect of Astragalus injection in a spinal cord ischemia-reperfusion (I/R) injury model. METHODS: A total of 27 Sprague Dawley rats were randomly divided into 3 groups: control group (n=3), I/R group (n=12), and Astragalus injection group (Ast group, n=12). Spinal cord ischemia was induced by occlusion of the abdominal aorta above the right renal artery for 32 min. Animals in the Ast group were administered Astragalus injection (6...
April 2018: Neurosciences: the Official Journal of the Pan Arab Union of Neurological Sciences
https://www.readbyqxmd.com/read/29663708/the-postmigratory-alar-topography-of-visceral-cranial-nerve-efferents-challenges-the-classical-model-of-hindbrain-columns
#4
Luis Puelles, Petr Tvrdik, Margaret Martínez-de-la-Torre
The classic columnar model of cranial nerve central representation assumes that all motor and sensory hindbrain neurons develop within four radial migration domains, held to be separated by a sulcal alar-basal boundary (sulcus limitans). This essay reviews a number of developmental data that challenge these concepts. These results are interpreted within the framework of present day neuromeric conception of the brainstem (the prosomeric model). Advances in dorsoventral patterning of the spinal cord and hindbrain now show that there exist up to eight alar microzones and five basal microzones (molecularly and histogenetically distinct longitudinal progenitor domains)...
April 16, 2018: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/29663410/the-negotiated-equilibrium-model-of-spinal-cord-function
#5
Jonathan R Wolpaw
The belief that the spinal cord is hardwired is no longer tenable. Like the rest of the CNS, the spinal cord changes during growth and aging, when new motor behaviours are acquired, and in response to trauma and disease. This paper describes a new model of spinal cord function that reconciles its recently appreciated plasticity with its long recognized reliability as the final common pathway for behaviour. According to this model, the substrate of each motor behaviour comprises brain and spinal plasticity: the plasticity in the brain induces and maintains the plasticity in the spinal cord...
April 16, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29659196/lessons-from-amphioxus-bauplan-about-origin-of-cranial-nerves-of-vertebrates-that-innervates-extrinsic-eye-muscles
#6
José Luis Ferran, Luis Puelles
Amphioxus is the living chordate closest to the ancestral form of vertebrates, and in a key position to reveal essential aspects of the evolution of the brain Bauplan of vertebrates. The dorsal neural cord of this species at the larval stage is characterized by a small cerebral vesicle at its anterior end and a large posterior region. The latter is comparable in some aspects to the hindbrain and spinal cord regions of vertebrates. The rostral end of the cerebral vesicle contains a median pigment spot and associated rows of photoreceptor and other nerve cells; this complex is known as "the frontal eye"...
April 16, 2018: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/29659159/spinal-accessory-motor-neurons-in-the-mouse-a-special-type-of-branchial-motor-neuron
#7
Charles Watson, Petr Tvrdik
The spinal accessory nerve arises from motor neurons in the upper cervical spinal cord. The axons of these motor neurons exit dorsal to the ligamentum denticulatum and form the spinal accessory nerve. The nerve ascends in the spinal subarachnoid space to enter the posterior cranial fossa through the foramen magnum. The spinal accessory nerve then turns caudally to exit through the jugular foramen alongside the vagus and glossopharyngeal nerves, and then travels to supply the sternomastoid and trapezius muscles in the neck...
April 16, 2018: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/29658149/coagulation-parameters-following-ehv-1-infection-in-horses
#8
M E Wilson, C L Holz, A K Kopec, J J Dau, J P Luyendyk, G Soboll Hussey
BACKGROUND: Equine herpesvirus type 1 (EHV-1) is the cause of respiratory disease, abortion storms, and outbreaks of herpesvirus myeloencephalopathy (EHM). Infection of the spinal cord is characterised by multifocal regions of virally infected vascular endothelia, associated with vasculitis, thrombosis and haemorrhage that result in ischaemia and organ dysfunction. However, the mechanism of thrombosis in affected horses is unknown. OBJECTIVES: To evaluate tissue factor (TF) procoagulant activity and thrombin-antithrombin complexes (TAT) levels in horses following infection with EHV-1...
April 15, 2018: Equine Veterinary Journal
https://www.readbyqxmd.com/read/29658103/genioglossus-reflex-responses-to-negative-upper-airway-pressure-are-altered-in-people-with-tetraplegia-and-obstructive-sleep-apnoea
#9
Nirupama S Wijesuriya, Laura Gainche, Amy S Jordan, David J Berlowitz, Mariannick LeGuen, Peter D Rochford, Fergal J O'Donoghue, Warren R Ruehland, Jayne C Carberry, Jane E Butler, Danny J Eckert
More than 60% of people with tetraplegia have obstructive sleep apnoea (OSA). However, the specific causes are unknown. Genioglossus, the largest upper-airway dilator muscle, is important in maintaining upper-airway patency. Impaired genioglossus muscle function following spinal cord injury may contribute to OSA. This study aimed to determine if genioglossus reflex responses to negative upper-airway pressure are altered in people with OSA and tetraplegia compared to non-neurologically impaired able-bodied individuals with OSA...
April 15, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29658057/combined-effects-of-rat-schwann-cells-and-17%C3%AE-estradiol-in-a-spinal-cord-injury-model
#10
Zeinab Namjoo, Fateme Moradi, Roya Aryanpour, Abbas Piryaei, Mohammad Taghi Joghataei, Yusef Abbasi, Amir Hosseini, Sajad Hassanzadeh, Fatemeh Ranjbar Taklimie, Cordian Beyer, Adib Zendedel
Spinal cord injury (SCI) is a devastating traumatic event which burdens the affected individuals and the health system. Schwann cell (SC) transplantation is a promising repair strategy after SCI. However, a large number of SCs do not survive following transplantation. Previous studies demonstrated that 17β-estradiol (E2) protects different cell types and reduces tissue damage in SCI experimental animal model. In the current study, we evaluated the protective potential of E2 on SCs in vitro and investigated whether the combination of hormonal and SC therapeutic strategy has a better effect on the outcome after SCI...
April 15, 2018: Metabolic Brain Disease
https://www.readbyqxmd.com/read/29656591/amp-activated-protein-kinase-dependent-induction-of-autophagy-by-erythropoietin-protects-against-spinal-cord-injury-in-rats
#11
Peng Wang, Zhong-Dong Xie, Chang-Nan Xie, Chao-Wei Lin, Ji-Li Wang, Li-Na Xuan, Chun-Wu Zhang, Yu Wang, Zhi-Hui Huang, Hong-Lin Teng
AIMS: Autophagy has been regarded as a promising therapeutic target for spinal cord injury (SCI). Erythropoietin (EPO) has been demonstrated to exhibit neuroprotective effects in the central nervous system (CNS); however, the molecular mechanisms of its protection against SCI remain unknown. This study aims to investigate whether the neuroprotective effects of EPO on SCI are mediated by autophagy via AMP-activated protein kinase (AMPK) signaling pathways. METHODS: Functional assessment and Nissl staining were used to investigate the effects of EPO on SCI...
April 15, 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29649627/overexpression-of-hipk2-attenuates-spinal-cord-injury-in-rats-by-modulating-apoptosis-oxidative-stress-and-inflammation
#12
Renbo Li, Jingbo Shang, Wei Zhou, Li Jiang, Donghui Xie, Guanjun Tu
HIPK2 is considered to be a tumor suppressor. It also has been implicated in several functions such as apoptosis and inflammation that are linked to spinal cord injury (SCI). However, whether HIPK2 ameliorates the neurological pain of SCI remains unclear. Here, we investigated the effects of HIPK2 on neurological function, oxidative stress, levels of inflammatory cytokines and expression of Bcl-2/Bax in an SCI model. Firstly, we evaluated the therapeutic effects of HIPK2 on neurological pain in the SCI rat using the Basso, Beattie and Bresnahan scores and H & E staining...
April 9, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29649262/antinociceptive-antibiotics-loaded-into-solid-lipid-nanoparticles-of-prolonged-release-measuring-pharmacological-efficiency-and-time-span-on-chronic-monoarthritis-rats
#13
Carlos Valdes, Gonzalo Bustos, Jose L Martinez, Claudio Laurido
Pain is a sensory experience of a complex physiological nature in which is not only involved the nervous system. Among its many features is the development of chronic pain that is more complicated to treat because of the central somatization processes involved, becoming inefficient treatments used in other forms of pain. Among them is the role of glial cells, whose participation is such that some authors have proposed to chronic pain as a gliopathy. Because of this, the drug target of possible treatments focuses on modulating nociceptive response affecting transduction into the central nervous system through affecting synapses in the dorsal horn of the spinal cord...
2018: PloS One
https://www.readbyqxmd.com/read/29627918/protective-effect-of-moderate-exogenous-electric-field-stimulation-on-activating-netrin-1-dcc-expression-against-mechanical-stretch-induced-injury-in-spinal-cord-neurons
#14
Meili Liu, Chuanwei Yin, Zhengtai Jia, Kun Li, Zhifa Zhang, Yuchen Zhao, Xianghui Gong, Xiaoyu Liu, Ping Li, Yubo Fan
Nerve cells detect and respond to electric field stimulation and extrinsic chemical guidance cues during development and regeneration; therefore, the development and optimization of an approach for functional neuronal regeneration are necessary for a nerve injury. In this study, we proposed using electric field stimulation to repair a nerve injury triggered by serious mechanical stretch loading. A device that provides continuous mechanical stretch and constant electric field stimulation was designed. Primary dissociated spinal cord neurons were stimulated by mechanical stretch (tensile strain 2...
April 7, 2018: Neurotoxicity Research
https://www.readbyqxmd.com/read/29624623/motion-and-dural-sac-compression-in-the-upper-cervical-spine-during-the-application-of-a-cervical-collar-in-case-of-unstable-craniocervical-junction-a-study-in-two-new-cadaveric-trauma-models
#15
Shiyao Liao, Niko R E Schneider, Petra Hüttlin, Paul A Grützner, Frank Weilbacher, Stefan Matschke, Erik Popp, Michael Kreinest
BACKGROUND: Unstable conditions of the craniocervical junction such as atlanto-occipital dislocation (AOD) or atlanto-axial instability (AAI) are severe injuries with a high risk of tetraplegia or death. Immobilization by a cervical collar to protect the patient from secondary damage is a standard procedure in trauma patients. If the application of a cervical collar to a patient with an unstable craniocervical condition may cause segmental motion and secondary injury to the spinal cord is unknown...
2018: PloS One
https://www.readbyqxmd.com/read/29619775/current-strategies-of-spinal-cord-protection-during-thoracoabdominal-aortic-surgery
#16
REVIEW
Akiko Tanaka, Hazim J Safi, Anthony L Estrera
Despite improved survival rates after thoracoabdominal aortic aneurysm repairs, paraplegia remains a devastating complication with high incidence, ranging from 3 to 10%. Ischemic insults to the spinal cord are unavoidable during thoracoabdominal aortic aneurysm repairs. There is no single measure that can prevent paraplegia alone. A multimodality approach is required to minimize the ischemic insults during thoracoabdominal aortic aneurysm repairs and postoperative second hit to the spinal cord. Distal aortic perfusion is important to maintain the collateral network perfusion pressure, while cerebrospinal drainage allows to directly maintain the spinal cord perfusion...
April 4, 2018: General Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29615863/the-d2-dopamine-receptor-interferes-with-the-protective-effect-of-the-a-2a-adenosine-receptor-on-tdp-43-mislocalization-in-experimental-models-of-motor-neuron-degeneration
#17
Chia-You Lai, Yu-Ju Liu, Hsing-Lin Lai, Hui-Mei Chen, Hung-Chi Kuo, Yu-Ping Liao, Yijuang Chern
The A2A adenosine receptor (A2A R) and D2 dopamine receptor (D2 R) are two G-protein-coupled receptors that can form dimers and negatively regulate their partners. TAR DNA-binding protein (TDP-43) is a nuclear protein that has been implicated in amyotrophic lateral sclerosis (ALS). Mislocalization of TDP-43 from the nucleus to the cytoplasm is an early step of TDP-43 proteinopathy. Our previous studies indicated that A2A R is a potential drug target for ALS because treatment with an A2A R agonist (JMF1907; a T1-11 analog) prevents reactive oxygen species (ROS)-induced TDP-43 mislocalization in a motor neuron cell line (NSC34) and delays motor impairment in a TDP-43 transgenic ALS mouse model...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29614353/necrosulfonamide-attenuates-the-spinal-cord-injury-via-necroptosis-inhibition
#18
Yongxiang Wang, Jingcheng Wang, Hua Wang, Xinmin Feng, Yuping Tao, Jiandong Yang, Jun Cai
Spinal cord injury (SCI) is a serious trauma without efficient treatment currently. Necroptosis can be blocked post injury by special inhibitors. To investigate the effects of Necrosulfonamide (NSA) in the treatment of SCI, pathological condition, necroptosis related factors, mitochondrial function and ethological performance were detected. Pathological detection using HE staining was performed first. Reduced lesions and protected neurons were found in the injured spinal cord after treatment with NSA. No obvious toxicity on rat liver, kidney, heart and spleen was detected using HE staining...
March 31, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29607694/taurine-attenuates-acrylamide-induced-apoptosis-via-a-pi3k-akt-dependent-manner
#19
G Sun, X Wang, T Li, S Qu, J Sun
As a potent neurotoxic agent, acrylamide (ACR) is formed in food processing at higher temperature. Taurine (TAU), a nonessential amino acid, is used to cure neurodegenerative disorders, followed by activation of the phosphatidylinositol 3-kinase/protein kinase B (PI3K/AKT) signaling pathway. In this article, we certified that antiapoptotic efficacy of TAU in vivo and vitro. ACR-treated rats received TAU by drinking water 2 weeks after ACR intoxication. The results showed that in treated rats, TAU alleviated ACR-induced neuronal apoptosis, which was associated with the activation of PI3K/AKT signaling pathway...
January 1, 2018: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/29605960/moderate-hypothermic-circulatory-arrest-%C3%A2-28%C3%A2-c-with-selective-antegrade-cerebral-perfusion-for-total-arch-replacement-with-frozen-elephant-trunk-technique
#20
Ali El-Sayed Ahmad, Petar Risteski, Mahmut Ay, Nestoras Papadopoulos, Anton Moritz, Andreas Zierer
OBJECTIVES:  The optimal hypothermic level during circulatory arrest in aortic arch surgery remains controversial, particularly in frozen elephant trunk (FET) procedures. We describe herein our experience for total arch replacement with FET technique under moderate systemic hypothermic circulatory arrest (≥ 28°C) during selective antegrade cerebral perfusion. METHODS:  Between January 2009 and January 2016, 38 consecutive patients underwent elective total arch replacement for various aortic arch pathologies with FET technique using the E-vita Open hybrid prosthesis (Jotec GmbH, Hechingen, Germany)...
April 1, 2018: Thoracic and Cardiovascular Surgeon
keyword
keyword
13306
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"