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Spinal cord protection

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https://www.readbyqxmd.com/read/29473323/adult-spinal-opioid-receptor-%C3%A2%C2%B51-expression-after-incision-is-altered-by-early-life-repetitive-tactile-and-noxious-procedures-in-rats
#1
Nynke J van den Hoogen, Roel Ri van Reij, Jacob Patijn, Dick Tibboel, Elbert Aj Joosten
Clinical and experimental data suggests that noxious stimulation at critical stages of development results in long-term changes on nociceptive processing in later life. Here, we use an established, well-documented rat model of repetitive noxious procedures closely mimicking the clinical situation in the NICU. In order to understand molecular changes underlying the long-term consequences of repetitive stimulation of the developing nociceptive system the present study aims to analyse the presence of the µ-opioid-receptor-1 (OPRM1)...
February 22, 2018: Developmental Neurobiology
https://www.readbyqxmd.com/read/29473171/nimodipine-confers-clinical-improvement-in-two-models-of-experimental-autoimmune-encephalomyelitis
#2
Jens Ingwersen, Lorenzo De Santi, Britta Wingerath, Jonas Graf, Barbara Koop, Reiner Schneider, Christina Hecker, Friederike Schröter, Mary Bayer, Anna Dorothee Engelke, Michael Dietrich, Philipp Albrecht, Hans-Peter Hartung, Pasquale Annunziata, Orhan Aktas, Tim Prozorovski
Multiple sclerosis (MS) is characterized by inflammatory neurodegeneration, with axonal injury and neuronal cell death occurring in parallel to demyelination. Regarding the molecular mechanisms responsible for demyelination and axonopathy, energy failure, aberrant expression of ion channels and excitotoxicity have been suggested to lead to Ca2+ overload and subsequent activation of calcium-dependent damage pathways. Thus, the inhibition of Ca2+ influx by pharmacological modulation of Ca2+ channels may represent a novel neuroprotective strategy in the treatment of secondary axonopathy...
February 23, 2018: Journal of Neurochemistry
https://www.readbyqxmd.com/read/29472775/resveratrol-an-antioxidant-protects-spinal-cord-injury-in-rats-by-suppressing-mapk-pathway
#3
Song Fu, Renhua Lv, Longqiang Wang, Haitao Hou, Haijun Liu, Shize Shao
Resveratrol, a polyphenol found in various plants, including grapes, plums and peanuts has shown various medIRInal properties, including antioxidant, protection of cardiovascular disease and cancer risk. However, the effects of resveratrol on spinal cord reperfusion injury have not been investigated. Hence, the present study was designed to evaluate the effect of resveratrol on nitric oxide synthase (iNOS)/p38MAPK signaling pathway and to elucidate its regulating effect on the protection of spinal cord injury...
February 2018: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/29467717/thioredoxin-1-protects-spinal-cord-from-demyelination-induced-by-methamphetamine-through-suppressing-endoplasmic-reticulum-stress-and-inflammation
#4
Lihua Yang, Yinli Guo, Mengbin Huang, Xiaoli Wu, Xiang Li, Guobing Chen, Ye Li, Jie Bai
Methamphetamine (METH) is a psychostimulant abused around the world. Emerging evidence indicates that METH causes brain damage. However, there are very few reports on METH-induced demyelination. Thioredoxin-1 (Trx-1) is a redox regulating protein and plays the roles in protecting neurons from various stresses. However, whether Trx-1 resists demyelination induced by METH has not been reported. In this study, we found that METH-induced thin myelin sheaths in spinal cord, whereas Trx-1 overexpression transgenic (TG) mice restored the myelin sheaths thickness...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29465295/predicting-complicated-outcomes-in-spinal-cord-injury-patients-with-urinary-tract-infection-development-and-internal-validation-of-a-risk-model
#5
Sheng Si, Yan Yan, Brian M Fuller, Stephen Y Liang
CONTEXT/OBJECTIVE: Patients with chronic SCI hospitalized for UTI can have significant morbidity. It is unclear whether SIRS criteria, SOFA score, or quick SOFA score can be used to predict complicated outcome. DESIGN: Retrospective cohort study. A risk prediction model was developed and internally validated using bootstrapping methodology. SETTING: Urban, academic hospital in St. Louis, Missouri. PARTICIPANTS: 402 hospitalizations for UTI between October 1, 2010 and September 30, 2015, arising from 164 patients with chronic SCI, were included in the final analysis...
February 21, 2018: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/29462125/increased-expression-of-trek-1-k-channel-in-the-dorsal-root-ganglion-of-rats-with-detrusor-overactivity-after-partial-bladder-outlet-obstruction
#6
Junlong Zhang, Mingxin Cao, Yu Chen, Zi Wan, Hua Wang, Huanyi Lin, Weijie Liang, Yueyou Liang
BACKGROUND Changes in expression and activity of ion channels are important pathophysiological mechanisms underlying detrusor overactivity (DO) in partial bladder outlet obstruction (PBOO). The objective of this study was to examine the expression of TREK-1 channel in the bladder and central nervous system of DO rats. MATERIAL AND METHODS Thirty Sprague-Dawley rats were subjected to PBOO operations and those displaying non-voiding contractions (NVCs) in cystometry were classified as DO. Sham-operated rats without NVCs in cystometry served as controls...
February 20, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29461585/microrna-125b-promotes-the-regeneration-and-repair-of-spinal-cord-injury-through-regulation-of-jak-stat-pathway
#7
J Dai, L-J Xu, G-D Han, H-L Sun, G-T Zhu, H-T Jiang, G-Y Yu, X-M Tang
OBJECTIVE: Spinal cord injury (SCI) is a severe trauma to the central nervous system. Long non-coding RNAs have been reported to play essential roles in spinal cord injury. This study mainly explored the role of micro-125 in the regulation of spinal cord injury by regulating STAT3. MATERIALS AND METHODS: The stable mouse model of cervical spinal cord contusion was established by Infinite Horizon spinal cord striker, and the model mice' motor function was analyzed...
February 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29455542/neuroprotective-effects-of-high-dose-human-albumin-against-traumatic-spinal-cord-injury-in-rats
#8
T Yildirim, O Okutan, E Akpinar, A Yilmaz, H S Isik
BACKGROUND AND OBJECTIVES: Human serum albumin (HA) is a unique multifunctional protein with neuroprotective properties. We aimed to delineate the mechanisms of HA-induced neuroprotection, supresses inflammatory response and lipid peroxidation after spinal cord injury (SCI). METHODS AND STUDY DESIGN: Adult female Wistar rats weighing 210-250 g were used for the study. The rats were randomly and blindly allocated into five groups. The one-way analysis of variance (ANOVA) for parametric data and Shapiro-Wilk test was used for evaluating the normal distribution of the variables...
2018: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/29453977/amelioration-of-progressive-autoimmune-encephalomyelitis-by-epigenetic-regulation-involves-selective-repression-of-mature-neutrophils-during-the-preclinical-phase
#9
Arathi Jayaraman, Monica Sharma, Bellur Prabhakar, Mark Holterman, Sundararajan Jayaraman
We have recently demonstrated that treatment of NOD mice with the epigenetic drug Trichostatin A (TSA) ameliorated myelin peptide induced progressive experimental autoimmune encephalomyelitis (P-EAE). Protection was accompanied by induction of antigen-specific T-cell tolerance in the periphery and reduced the influx of T cells into the spinal cord. In this investigation, we examined whether the epigenetic drug could impact the innate immune system as well. Whereas the mature (MHC class II + ) CD11b + Ly-6G + neutrophils expanded substantially in the peripheral lymphoid compartment during the preclinical phase, the MHC class II + , CD11b + Ly-6C + mature monocytes increased modestly throughout the disease course...
February 14, 2018: Experimental Neurology
https://www.readbyqxmd.com/read/29451306/supraspinal-modulation-of-neuronal-synchronization-by-nociceptive-stimulation-induces-an-enduring-reorganization-of-dorsal-horn-neuronal-connectivity
#10
E Contreras-Hernández, D Chávez, E Hernández, E Velázquez, P Reyes, J Bejar, M Martín, U Cortés, S Glusman, P Rudomin
Despite the profuse information on the molecular and cellular mechanisms involved in the central sensitization produced by intense nociceptive stimulation, the changes in the patterns of functional connectivity between spinal neurones associated with the development of secondary hyperalgesia and allodynia remain largely unknown. Here we show that the state of central sensitization produced by the intradermal injection of capsaicin is associated with structured transformations in neuronal synchronization that lead to an enduring reorganization of the functional connectivity within a segmentally distributed ensemble of dorsal horn neurones...
February 16, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29444353/healthcare-resource-utilisation-associated-with-skeletal-related-events-in-european-patients-with-multiple-myeloma-results-from-a-prospective-multinational-observational-study
#11
John Ashcroft, Ignacio Duran, Herbert Hoefeler, Vito Lorusso, Diana Lueftner, Marco Campioni, Michele Intorcia, Amit Bahl
OBJECTIVES: Patients with multiple myeloma (MM) often experience debilitating skeletal-related events (SREs: pathologic fracture, radiation to bone [RB], surgery to bone [SB] or spinal cord compression [SCC]). This is the first comprehensive, prospective, observational analysis of healthcare resource utilisation (HRU), independently attributed to SREs by investigators, in patients with MM. METHODS: Eligible patients had lytic bone lesions, life expectancy ≥6 months, Eastern Cooperative Oncology Group performance status ≤2, and ≥1 SRE in the 97 days before enrolment...
February 14, 2018: European Journal of Haematology
https://www.readbyqxmd.com/read/29441625/biodegradable-spheres-protect-traumatically-injured-spinal-cord-by-alleviating-the-glutamate-induced-excitotoxicity
#12
Dongfei Liu, Jian Chen, Tao Jiang, Wei Li, Yao Huang, Xiyi Lu, Zehua Liu, Weixia Zhang, Zheng Zhou, Qirui Ding, Hélder A Santos, Guoyong Yin, Jin Fan
New treatment strategies for spinal cord injury with good therapeutic efficacy are actively pursued. Here, acetalated dextran (AcDX), a biodegradable polymer obtained by modifying vicinal diols of dextran, is demonstrated to protect the traumatically injured spinal cord. To facilitate its administration, AcDX is formulated into microspheres (≈7.2 µm in diameter) by the droplet microfluidic technique. Intrathecally injected AcDX microspheres effectively reduce the traumatic lesion volume and inflammatory response in the injured spinal cord, protect the spinal cord neurons from apoptosis, and ultimately, recover the locomotor function of injured rats...
February 14, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29436158/spinal-cord-stimulator-electrode-dislodging-into-the-ligamentum-flavum-a-case-report
#13
Aaron J Martin, Devang Padalia, Neal Shah, Jaspreet Singh, Navdeep Jassal
Since the introduction of spinal cord stimulation for the treatment of pain in 1967, the technology has progressed dramatically with continual device evolution and increasing number of approved indications. Despite constant refinement of the device design, the average complication rate has been estimated at 30-40%, with 74% of the reported complications being device related. The most common of these include lead migration, fracture, and disconnection from the generator. To date, no cases specifically reporting an electrode dislodging from its lead wire have been reported...
February 12, 2018: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/29434186/preconditioning-induced-by-sub-toxic-dose-of-the-neurotoxin-l-bmaa-delays-als-progression-in-mice-and-prevents-na-ca2-exchanger-3-downregulation
#14
Serenella Anzilotti, Paola Brancaccio, Giuseppe Simeone, Valeria Valsecchi, Antonio Vinciguerra, Agnese Secondo, Tiziana Petrozziello, Natascia Guida, Rossana Sirabella, Ornella Cuomo, Pasquale Cepparulo, Andrè Herchuelz, Salvatore Amoroso, Gianfranco Di Renzo, Lucio Annunziato, Giuseppe Pignataro
Preconditioning (PC) is a phenomenon wherein a mild insult induces resistance to a later, severe injury. Although PC has been extensively studied in several neurological disorders, no studies have been performed in amyotrophic lateral sclerosis (ALS). Here we hypothesize that a sub-toxic acute exposure to the cycad neurotoxin beta-methylamino-L-alanine (L-BMAA) is able to delay ALS progression in SOD1 G93A mice and that NCX3, a membrane transporter able to handle the deregulation of ionic homeostasis occurring during ALS, takes part to this neuroprotective effect...
February 12, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29432301/adenovirus-delivered-gfp-ho-1c-increment-23-attenuates-blood-spinal-cord-barrier-permeability-after-rat-spinal-cord-contusion
#15
Sheng Chang, Yunlong Bi, Xiangwei Meng, Lin Qu, Yang Cao
The blood-spinal cord barrier (BSCB) plays a key role in maintaining the microenvironment and is primarily composed of tight junction proteins and nonfenestrated capillary endothelial cells. After injury, BSCB damage results in increasing capillary permeability and release of inflammatory factors. Recent studies have reported that haem oxygenase-1 (HO-1) fragments lacking 23 amino acids at the C-terminus (HO-1C[INCREMENT]23) exert novel anti-inflammatory and antioxidative effects in vitro. However, no study has identified the role of HO-1C[INCREMENT]23 in vivo...
February 9, 2018: Neuroreport
https://www.readbyqxmd.com/read/29430715/characterization-and-comparison-of-rat-monosodium-iodoacetate-and-medial-meniscal-tear-models-of-osteoarthritic-pain
#16
Jill-Desiree Brederson, Katharine L Chu, Jun Xu, Arthur L Nikkel, Stella Markosyan, Michael F Jarvis, Rebecca Edelmayer, Robert S Bitner, Steve McGaraughty
Osteoarthritis (OA) is a degenerative form of arthritis that can result in loss of joint function and chronic pain. The pathological pain state that develops with OA disease involves plastic changes in the peripheral and central nervous systems, however, the cellular mechanisms underlying OA are not fully understood. We characterized the medial meniscal tear (MMT) surgical model and the intra-articular injection of monosodium iodoacetate (MIA) chemical model of OA in rats. Both models produced histological changes in the knee joint and associated bones consistent with OA pathology...
February 11, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29430662/on-the-feasibility-of-automatically-selecting-similar-patients-in-highly-individualized-radiotherapy-dose-reconstruction-for-historic-data-of-pediatric-cancer-survivors
#17
Marco Virgolin, Irma W E M van Dij, Jan Wiersma, Cécile M Ronckers, Cees Witteveen, Arjan Bel, Tanja Alderliesten, Peter A N Bosman
PURPOSE: The aim of this study is to establish the first step towards a novel and highly individualized 3D dose distribution reconstruction method, based on CT scans and organ delineations of recently treated patients. Specifically, the feasibility of automatically selecting the CT scan of a recently treated childhood cancer patient who is similar to a given historically treated child who suffered from Wilms' tumor is assessed. METHODS: A cohort of 37 recently treated children between 2 and 6 years old is considered...
February 12, 2018: Medical Physics
https://www.readbyqxmd.com/read/29428242/bu-shen-yi-sui-capsule-promotes-remyelination-correlating-with-sema3a-nrp-1-lif-lifr-and-nkx6-2-in-mice-with-experimental-autoimmune-encephalomyelitis
#18
Pei-Yuan Zhao, Yong-Qiang Wang, Xi-Hong Liu, Ying-Jun Zhu, Hui Zhao, Qiu-Xia Zhang, Fang Qi, Jun-Ling Li, Nan Zhang, Yong-Ping Fan, Kang-Ning Li, Yuan-Yuan Zhao, Jian-Feng Lei, Lei Wang
ETHNOPHARMACOLOGICAL RELEVANCE: Bu Shen Yi Sui capsule (BSYSC), based on traditional Chinese formula Liu Wei Di Huang pill, is effective for the treatment of multiple sclerosis (MS) in clinical experience and trials. Our previous studies confirmed that BSYSC had the neuroprotective effect in MS and its animal model, experimental autoimmune encephalomyelitis (EAE); however, its mechanism of action was not clear. Thus, the effect of BSYSC on remyelination and the underlying mechanisms were investigated in the EAE mice...
February 8, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29423951/early-calp2-expression-and-microglial-activation-are-potential-inducers-of-spinal-il-6-upregulation-and-bilateral-pain-following-motor-nerve-injury
#19
Shao-Xia Chen, Shao-Kun Wang, Pei-Wen Yao, Guang-Jie Liao, Xiao-Dong Na, Yong-Yong Li, Wei-An Zeng, Xian-Guo Liu, Ying Zang
Previous work from our laboratory showed that motor nerve injury by lumbar 5 ventral root transection (L5-VRT) led to interleukin-6 (IL-6) overexpression in bilateral spinal cord, and that intrathecal administration of IL-6 neutralizing antibody delayed the induction of mechanical allodynia in bilateral hind paws. However, early events and upstream mechanisms underlying spinal IL-6 expression following L5-VRT require elucidation. The model of L5-VRT was used to induce neuropathic pain, which was assessed with von Frey hairs and the plantar tester in adult male Sprague-Dawley rats...
February 9, 2018: Journal of Neurochemistry
https://www.readbyqxmd.com/read/29423932/protein-translation-proteolysis-and-autophagy-in-human-skeletal-muscle-atrophy-after-spinal-cord-injury
#20
Leonidas S Lundell, Mladen Savikj, Emil Kostovski, Per Ole Iversen, Juleen R Zierath, Anna Krook, Alexander V Chibalin, Ulrika Widegren
AIM: Spinal cord injury-induced loss of skeletal muscle mass does not progress linearly. In humans, peak muscle loss occurs during the first six weeks post-injury, and gradually continues thereafter. The aim of this study was to delineate the regulatory events underlying skeletal muscle atrophy during the first year following spinal cord injury. METHODS: Key translational, autophagic and proteolytic proteins were analyzed by immunoblotting of human vastus lateralis muscle obtained 1, 3 and 12 month's following spinal cord injury...
February 8, 2018: Acta Physiologica
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