keyword
MENU ▼
Read by QxMD icon Read
search

Postconditioning

keyword
https://www.readbyqxmd.com/read/29331396/autophagy-in-ischemic-stroke
#1
REVIEW
Pei Wang, Bo-Zong Shao, Zhiqiang Deng, Shi Chen, Zhenyu Yue, Chao-Yu Miao
Autophagy is a self-eating cellular catabolic pathway, through which long-lived proteins, damaged organelles and misfolded proteins are degraded and recycled for the maintenance of cellular homeostasis and normal cellular functions. Autophagy plays an important homeostatic role in the regulation of cell survival. Accumulating evidence shows that autophagy is activated in various cell types in the brain such as neurons, glia cells, and brain microvascular cells upon ischemic stroke. However, the exact role and molecular mechanisms of autophagy process that is implicated in ischemic stroke have yet to be elucidated...
January 10, 2018: Progress in Neurobiology
https://www.readbyqxmd.com/read/29328382/propofol-postconditioning-protects-h9c2-cells-from-hypoxia-reoxygenation-injury-by-inducing-autophagy-via-the-sapk-jnk-pathway
#2
Hao Li, Xuan Zhang, Jian Tan, Li Sun, Long-He Xu, Yu-Ge Jiang, Jing-Sheng Lou, Xue-Yin Shi, Wei-Dong Mi
Propofol postconditioning (P‑PostC) offers cardioprotection in mice, and the upregulation of autophagy protects cardiac cells against ischemia/reperfusion injury. The present study aimed to examine the effects of P‑PostC on the induction of autophagy and its potential roles in hypoxia/reoxygenation (H/R) injury. Rat heart‑derived H9c2 cells were exposed to H/R, comprising 6 h of hypoxia followed by 4 h of reoxygenation, as well as postconditioning with various concentrations of propofol at the onset of reperfusion...
January 11, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29306618/milrinone-induced-postconditioning-requires-activation-of-mitochondrial-ca2-sensitive-potassium-mbkca-channels
#3
Friederike Behmenburg, Lara Trefz, Marianne Dorsch, Martin Ströthoff, Alexander Mathes, Annika Raupach, André Heinen, Markus W Hollmann, Marc M Berger, Ragnar Huhn
OBJECTIVES: Cardioprotection by postconditioning requires activation of mitochondrial large-conductance Ca2+-sensitive potassium (mBKCa) channels. The involvement of these channels in milrinone-induced postconditioning is unknown. The authors determined whether cardioprotection by milrinone-induced postconditioning involves activation of mBKCa channels in the rat heart in vitro. DESIGN: Randomized, prospective, blinded laboratory investigation. SETTING: Experimental laboratory...
November 29, 2017: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29288664/hydrogen-postconditioning-promotes-survival-of-rat-retinal-ganglion-cells-against-ischemia-reperfusion-injury-through-the-pi3k-akt-pathway
#4
Jiangchun Wu, Ruobing Wang, Dianxu Yang, Wenbin Tang, Zeli Chen, Qinglei Sun, Lin Liu, Rongyu Zang
Retinal ischemia/reperfusion injury (IRI) plays a crucial role in the pathophysiology of various ocular diseases. Our previous study have shown that postconditioning with inhaled hydrogen (H2) (HPC) can protect retinal ganglion cells (RGCs) in a rat model of retinal IRI. Our further study aims to investigate potential mechanisms underlying HPC-induced protection. Retinal IRI was performed on the right eyes of rats and was followed by inhalation of 67% H2 mixed with 33% oxygen immediately after ischemia for 1 h daily for one week...
December 27, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29273639/adverse-effects-on-%C3%AE-adrenergic-receptor-coupling-ischemic-postconditioning-failed-to-preserve-long-term-cardiac-function
#5
Rolf Schreckenberg, Péter Bencsik, Martin Weber, Yaser Abdallah, Csaba Csonka, Kamilla Gömöri, Krisztina Kiss, János Pálóczi, Judit Pipis, Márta Sárközy, Péter Ferdinandy, Rainer Schulz, Klaus-Dieter Schlüter
BACKGROUND: Ischemic preconditioning (IPC) and ischemic postconditioning (IPoC) are currently among the most efficient strategies protecting the heart against ischemia/reperfusion injury. However, the effect of IPC and IPoC on functional recovery following ischemia/reperfusion is less clear, particularly with regard to the specific receptor-mediated signaling of the postischemic heart. The current article examines the effect of IPC or IPoC on the regulation and coupling of β-adrenergic receptors and their effects on postischemic left ventricular function...
December 22, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29273367/the-rat-groin-flap-model-redesigned-for-evaluating-treatment-effects-on-ischemia-reperfusion-injury
#6
Chung-En Hsu, Victor Bong-Hang Shyu, Chih-Jen Wen, Fu-Chan Wei, Xiao-Ting Huang, Hui-Yun Cheng
BACKGROUND: Although there is a wide application of the rat extended groin flap (epigastric skin flap) in studying different clinical issues, inconsistency arises between studies because many parameters of the extended groin flap have not been well defined. MATERIALS AND METHODS: The flap is based on the superficial inferior epigastric vessels, which give into a lateral and a medial branch distally. Herein, three steps were taken to redesign this model: First, the ventral vascular anatomy was visualized through an imaging study to determine the flap borders...
February 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29242986/pre-and-postconditioning-the-heart-with-hydrogen-sulfide-h2s-against-ischemia-reperfusion-injury-in-vivo-a-systematic-review-and-meta-analysis
#7
REVIEW
Qutuba G Karwi, Justin S Bice, Gary F Baxter
Conditioning-like infarct limitation by enhanced level of hydrogen sulfide (H2S) has been demonstrated in many animal models of myocardial ischemia/reperfusion injury (MIRI) in vivo. We sought to evaluate the effect of H2S on myocardial infarction across in vivo pre-clinical studies of MIRI using a comprehensive systematic review followed by meta-analysis. Embase, Pubmed and Web of Science were searched for pre-clinical investigation of the effect of H2S on MIRI in vivo. Retained records (6031) were subjected to our pre-defined inclusion criteria then were objectively critiqued...
December 14, 2017: Basic Research in Cardiology
https://www.readbyqxmd.com/read/29225152/a-randomized-controlled-trial-of-intra-aortic-adenosine-infusion-before-release-of-the-aortic-cross-clamp-during-coronary-artery-bypass-surgery
#8
Amany Ammar, Khaled Mahmoud, Ahmed Elkersh, Zeinab Kasemy
OBJECTIVES: To assess the feasibility, safety, and potential useful effect of adenosine as a postconditioning agent in patients undergoing coronary artery bypass grafting surgeries. DESIGN: Prospective randomized controlled study. SETTING: University hospital. PARTICIPANTS: The study comprised 60 patients scheduled for coronary artery bypass grafting surgery. INTERVENTIONS: Adenosine (postconditioning group) or placebo (control group)...
December 7, 2017: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29221232/ischemic-postconditioning-during-primary-percutaneous-coronary-interventions-not-ready-for-prime-time
#9
EDITORIAL
Shahar Lavi, Ronit Lavi
No abstract text is available yet for this article.
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29195182/a-mitochondrial-targeting-near-infrared-fluorescent-probe-for-bioimaging-and-evaluating-endogenous-superoxide-anion-changes-during-ischemia-reperfusion-injury
#10
Xiaoyue Han, Rui Wang, Xinyu Song, Fabiao Yu, Changjun Lv, Lingxin Chen
The outburst of superoxide anion (O2-) in mitochondrial during ischemia/reperfusion (I/R) process will cause a series of oxidative damage including polarity loss of mitochondrial membrane potential, overload of secondary cellular calcium, and cascade apoptosis. To monitor the O2- level fluctuations as well as to evaluate the relationship between O2- concentration and the degree of cell apoptosis during I/R process, we propose a ratiometric near-infrared mitochondrial targeting fluorescent probe Mito-Cy-Tfs for the detection of level changes of O2- in cells and in vivo...
November 23, 2017: Biomaterials
https://www.readbyqxmd.com/read/29180332/-effect-of-dexmedetomidine-postconditioning-on-myocardial-ischemia-reperfusion-injury-and-inflammatory-response-in-diabetic-rats
#11
Jing Hu, Xiao-Yu Gu, Yan Meng, Ya Wang, Qin Gao, Zheng-Hong Li, Xiao-Hong Li, Xiang-Yang Cheng
OBJECTIVE: To investigate the effect of dexmedetomidine postconditioning in alleviating myocardial ischemia-reperfusion (IR) injury and inflammation in diabetic mellitus rats. METHODS: Thirty normal male Sprauge Dawley (SD) rats were randomly allocated into 3 groups (n=10), namely the sham-operated group, IR group, and dexmedetomidine postconditioning (DP) group. Similarly, another thirty diabetic SD rats were also randomly allocated into diabetic sham (DM-S) group, diabetic IR (DM-IR) group and diabetic dexmedetomidine postconditioning (DM-DP) group...
November 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/29179175/novel-functional-role-of-heat-shock-protein-90-in-mitochondrial-connexin-43-mediated-hypoxic-postconditioning
#12
Rong-Hui Tu, Qing-Jie Li, Zheng Huang, Yan He, Jian-Jun Meng, Hui-Lei Zheng, Zhi-Yu Zeng, Guo-Qiang Zhong
BACKGROUND/AIMS: Previous studies have shown that heat shock protein 90 (HSP90)-mediated mitochondrial import of connexin 43 (Cx43) is critical in preconditioning cardioprotection. The present study was designed to test whether postconditioning has the same effect as preconditioning in promoting Cx43 translocation to mitochondria and whether mitochondrial HSP90 modulates this effect. METHODS: Cellular models of hypoxic postconditioning (HPC) from rat heart-derived H9c2 cells and neonatal rat cardiomyocytes were employed...
November 27, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29170412/ischemic-postconditioning-protects-against-intestinal-ischemia-reperfusion-injury-via-the-hif-1%C3%AE-mir-21-axis
#13
Zhongzhi Jia, Weishuai Lian, Haifeng Shi, Chuanwu Cao, Shilong Han, Kai Wang, Maoquan Li, Xiaoping Zhang
Intestinal ischemia/reperfusion (I/R) can lead to tissue damage associated with inflammation and mucosal apoptosis. Ischemic postconditioning (IPostC), a series of repeated, brief, intermittent periods of ischemia and reperfusion, has beneficial effects against I/R-induced injury in the heart and intestine, although the underlying mechanisms for these effects remain unclear. We evaluated the involvement of microRNA-21 (miR-21) in the protective effects of IPostC in a rat model of I/R induced by superior mesenteric artery occlusion and reopening...
November 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29169417/-overexpression-of-ppenk-reduces-myocardial-ischemia-reperfusion-injury-by-promoting-mitophagy-in-rats
#14
Yan Wang, Xiaoe Lu, Pin Zhao, Jing Jiang, Linong Yao
Objective To investigate the effect of preproenkephalin-minimalistic immunologically defined gene expression-nuclear localization signal (PPENK-MIDGE-NLS) vector postconditioning on mitophagy during myocardial ischemia reperfusion in rats. Methods Forty male SD rats were randomly divided into 4 groups: sham operation group, ischemia reperfusion group, PPENK-MIDGE-NLS group and Control-MIDGE-NLS group. Myocardial ischemia reperfusion injury model was induced by ligating left anterior descending branch of coronary artery (LAD)...
October 2017: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://www.readbyqxmd.com/read/29159507/stat3-as-a-common-signal-of-ischemic-conditioning-a-lesson-on-rigor-and-reproducibility-in-preclinical-studies-on-cardioprotection
#15
Petra Kleinbongard, Andreas Skyschally, Sabine Gent, Marion Pesch, Gerd Heusch
Ischemic conditioning before (ischemic preconditioning, IPC) or after (ischemic postconditioning, POCO) sustained myocardial ischemia/reperfusion (I/R), induced locally or remotely from the heart (remote IPC, RIPC), reduces infarct size. However, none of the identified signaling steps of ischemic conditioning was robust across models and species to be successfully translated to humans. In prior separate studies in pigs, activation of signal transducer and activator of transcription 3 (STAT3) was causal for infarct size reduction by IPC, POCO, and RIPC but it remains unclear whether or not STAT3 is truly a common denominator of cardioprotective signaling...
November 20, 2017: Basic Research in Cardiology
https://www.readbyqxmd.com/read/29147482/combined-postconditioning-with-ischemia-and-cyclosporine-a-restore-oxidative-stress-and-histopathological-changes-in-reperfusion-injury-of-diabetic-myocardium
#16
Reza Badalzadeh, Seyed Mahmoud Tabatabaei, Mustafa Mohammadi, Arash Khaki, Dariush Mohammadnezhad
Objectives: Chronic diabetes impedes cardioprotection in reperfusion injury and hence protecting the diabetic heart would have important outcomes. In this study, we evaluated whether combined postconditioning with ischemia and cyclosporine-A can restore oxidative stress and histopathological changes in reperfusion injury of the diabetic myocardium. Materials and Methods: Streptozocin-induced diabetic hearts and nondiabetic controls in eight subgroups (with or without receiving ischemic-postconditioning (IPostC), cyclosporine-A, an inhibitor of mitochondrial permeability transition, or both of them) suffered from 30 min regional ischemia followed by 45 min reperfusion on an isolated-heart Langendorff system...
October 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29142491/impact-of-remote-ischemic-postconditioning-during-primary-percutaneous-coronary-intervention-on-left-ventricular-remodeling-after-anterior-wall-st-segment-elevation-myocardial-infarction-a-single-center-experience
#17
Ayman Elbadawi, Omar Awad, Ramy Raymond, Haytham Badran, Ahmad E Mostafa, Marwan Saad
The role of remote ischemic postconditioning (RIPostC) in improving left ventricular (LV) remodeling after primary percutaneous coronary intervention (PCI) is not well established. To determine the efficacy and safety of RIPostC in improving LV remodeling and cardiovascular outcomes after primary PCI for anterior ST-elevation myocardial infarction (STEMI). Seventy-one patients with anterior STEMI were randomized to primary PCI with RIPostC protocol ( n  = 36) versus conventional primary PCI ( n  = 35)...
December 2017: International Journal of Angiology: Official Publication of the International College of Angiology, Inc
https://www.readbyqxmd.com/read/29113143/sevoflurane-postconditioning-induced-anti-inflammation-via-inhibition-of-the-toll-like-receptor-4-nuclear-factor-kappa-b-pathway-contributes-to-neuroprotection-against-transient-global-cerebral-ischemia-in-rats
#18
Jung-Won Hwang, Young-Tae Jeon, Young-Jin Lim, Hee-Pyoung Park
The anti-inflammatory actions of sevoflurane postconditioning are suggested as an important mechanism of sevoflurane postconditioning-induced neuroprotection against cerebral ischemia. Here, we determined whether the anti-inflammatory effects of sevoflurane postconditioning were mediated via inhibition of the toll-like receptor (TLR)-4/nuclear factor kappa B (NF-κB) pathway after global transient cerebral ischemia in rats. Forty-five rats were randomly assigned to five groups as follows: (1) control (10 min of ischemia, n = 10); (2) sevoflurane postconditioning (two periods of sevoflurane inhalation after ischemia for 10 min with a wash period of 10 min, n = 10); (3) resatorvid (intraperitoneal injection of a selective TLR-4 antagonist (3 mg/kg) 30 min before ischemia, n = 10); (4) sevoflurane postconditioning plus resatorvid (n = 10), and sham (n = 5)...
November 6, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29108311/remote-ischemic-conditioning-for-the-prevention-of-contrast-induced-acute-kidney-injury-in-patients-undergoing-intravascular-contrast-administration-a-meta-analysis-and-trial-sequential-analysis-of-16-randomized-controlled-trials
#19
Chang-Cheng Zhou, Wen-Tao Yao, Yu-Zheng Ge, Lu-Wei Xu, Ran Wu, Xiao-Fei Gao, Kai-Wei Song, Xiao-Min Jiang, Min Wang, Wen-Juan Huang, Yun-Peng Zhu, Liang-Peng Li, Liu-Hua Zhou, Zhong-Le Xu, Sheng-Li Zhang, Jia-Geng Zhu, Wen-Cheng Li, Rui-Peng Jia
Objective: We conducted this meta-analysis to examine the effect of remote ischemic conditioning (RIC) on contrast-induced acute kidney injury (CI-AKI) in patients undergoing intravascular contrast administrationon. Methods: Pubmed, Embase, and Cochrane Library were comprehensively searched to identify all eligible studies by 15th March, 2017. Risk ratio (RR) and weighted mean difference with the corresponding 95% confidence intervals (CI) were used to examine the treatment effect...
October 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29076346/a-systematic-review-and-meta-analysis-evaluating-ischemic-conditioning-during-percutaneous-coronary-intervention
#20
David I Blusztein, Matthew J Brooks, David T Andrews
AIM: A systematic review and meta-analysis, evaluating ischemic conditioning during percutaneous coronary intervention (PCI). METHODS & RESULTS: A database search of randomized trials of ischemic conditioning in PCI created three subgroups for meta-analysis: mortality in elective PCI with remote ischemic preconditioning (RIPreC; subgroup 1a, n = 3) - no outcome difference between RIPreC and control (odds ratio: 0.34; 95% CI: 0.08-1.56), myocardial salvage index in ST-elevation myocardial infarction (STEMI) with RIPreC (subgroup 1b, n = 2) - favored RIPreC (mean difference: 0...
November 2017: Future Cardiology
keyword
keyword
13305
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"