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Vaccines post transplant

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https://www.readbyqxmd.com/read/29093083/dynamics-of-sendai-virus-spread-clearance-and-immunotherapeutic-efficacy-after-hematopoietic-cell-transplant-imaged-non-invasively-in-mice
#1
Heba H Mostafa, Peter Vogel, Ashok Srinivasan, Charles J Russell
There are no approved vaccines or virus-specific treatments for human parainfluenza viruses (PIVs), which have recently been reclassified into species human respirovirus 1 and 3 and human rubulavirus 2 and 4 These viruses cause morbidity and mortality in immunocompromised patients including those undergoing hematopoietic cell transplant (HCT). No small-animal models exist for non-invasive imaging of respiratory viral infection in the HCT host despite the utility such a system would offer to monitor prolonged infection, its clearance, and treatment options...
November 1, 2017: Journal of Virology
https://www.readbyqxmd.com/read/29042204/antibody-response-to-human-papillomavirus-vaccination-and-natural-exposure-in-individuals-with-fanconi-anemia
#2
Parinda A Mehta, Sharon Sauter, Xue Zhang, Stella M Davies, Suzanne I Wells, Kasiani C Myers, Gitika Panicker, Elizabeth R Unger, Melinda Butsch Kovacic
Fanconi anemia (FA) is a rare genetic disorder associated with predisposition to head and neck and gynecological squamous cell cancers. In the general population, these cancers are commonly linked to human papillomavirus (HPV) infection. Antibodies to natural HPV infection and HPV vaccination were evaluated in 63 individuals with FA while considering host immune factors. Approximately 30% of reportedly unvaccinated participants were seropositive (HPV6-38%, HPV11-25%, HPV16-26%, and HPV18-26%). Seropositivity was significantly associated with having had sex regardless of age (p=...
October 14, 2017: Vaccine
https://www.readbyqxmd.com/read/29036810/naturalizing-activity-and-safety-of-human-monoclonal-antibodies-against-of-hepatitis-c-virus
#3
Tawfeek H Abelhafez, Ashraf A Tabll, Mostafa K El-Awady, Mohammad M Mashaly, Reem El Shenawy, Yasmine S El-Abd, Maysa H Shaker, Camelia A Abdel Malak
AIM: Assessment of neutralizing activity of the human monoclonal antibodies against HCV and also study its safety in experimental small animals (Swiss mice). MATERIALS AND METHODS: Assessment of neutralizing activity of the human monoclonal antibodies against HCV envelope regions (E1, E2) by two methods (by HCV cc infectious system and by using positive HCV positive serum as source of HCV particles (neutralizing assay 2). Dot ELISA were used to study the activity of the generated antibodies...
September 29, 2017: Human Antibodies
https://www.readbyqxmd.com/read/29017655/-application-of-active-immunization-in-the-prevention-of-de-novo-hepatitis-b-virus-infection-after-pediatric-liver-transplantation-with-hbcab-positive-donor-liver
#4
Yufeng Cui, Wei Lu, Wei Gao, Chong Dong, Chao Han, Yihe Liu
OBJECTIVE: To investigate the effect of active immunization on prevention of post-transplantation de novo hepatitis B virus (HBV) infection in patients receiving liver grafts from hepatitis B core antibody (HBcAb) positive donors. METHODS: A retrospective analysis was conducted. Eighty-seven children undergoing liver transplantation from HBcAb positive donors admitted to Tianjin First Center Hospital from October 2012 to December 2016 were enrolled, and the data of donors and recipients were collected...
October 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/28983694/incomplete-vaccination-coverage-in-european-children-with-end-stage-kidney-disease-prior-to-renal-transplantation
#5
Britta Höcker, Martin Aguilar, Paul Schnitzler, Lars Pape, Luca Dello Strologo, Nicholas J A Webb, Martin Bald, Gurkan Genc, Heiko Billing, Jens König, Anja Büscher, Markus J Kemper, Stephen D Marks, Martin Pohl, Marianne Wigger, Rezan Topaloglu, Susanne Rieger, Kai Krupka, Thomas Bruckner, Alexander Fichtner, Burkhard Tönshoff
BACKGROUND: Because infections constitute a major cause of morbidity and mortality in paediatric renal allograft recipients, avoidance of preventable systemic infections by vaccination before transplantation is of utmost importance. However, data on the completeness of vaccinations and factors associated with incomplete vaccination coverage are scarce. METHODS: Within the framework of the Cooperative European Paediatric Renal Transplant Initiative (CERTAIN), we therefore performed a multi-centre, multi-national, retrospective study investigating the vaccination coverage before transplantation of 254 European children with end-stage renal disease (mean age 10...
October 5, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/28965937/pneumococcal-polysaccharide-vaccination-in-allogeneic-hematopoietic-stem-cell-transplantation-recipients-a-prospective-single-center-study
#6
Keiji Okinaka, Yukihiro Akeda, Saiko Kurosawa, Shigeo Fuji, Kinuko Tajima, Kazunori Oishi, Takahiro Fukuda
Few studies have evaluated the response of allogeneic hematopoietic stem cell transplantation [allo-HSCT] recipients to pneumococcal polysaccharide vaccine-23 [PPSV23] in the modern transplant era when more elderly patients undergo allo-HSCT. We administered a single dose of PPSV23 to 30 allo-HSCT recipients and evaluated serotype-specific antibody responses using IgG measured by enzyme-linked immunosorbent assay and opsonophagocytic assay [OPA] titers in a multiplexed opsonophagocytic killing assay. The median patient age was 54 years [range, 23-68], and the interval from allo-HSCT to vaccination was 756 days [range, 389-1903]...
September 29, 2017: Microbes and Infection
https://www.readbyqxmd.com/read/28965331/post-transplant-viral-respiratory-infections-in-the-older-patient-epidemiology-diagnosis-and-management
#7
REVIEW
Nancy Law, Deepali Kumar
Organ and stem cell transplantation has been one of the greatest advances in modern medicine, and is the primary treatment modality for many end-stage diseases. As our population ages, so do the transplant recipients, and with that comes many new challenges. Respiratory viruses have been a large contributor to the mortality and morbidity of solid organ transplant (SOT) and hematopoietic stem cell transplant (HSCT) recipients. Respiratory viruses are generally a long-term complication of transplantation and primarily acquired in the community...
October 2017: Drugs & Aging
https://www.readbyqxmd.com/read/28945107/herpes-zoster-incidence-and-cost-in-patients-receiving-autologous-hematopoietic-stem-cell-transplant
#8
Jianbin Mao, Jeffrey T McPheeters, Dongmu Zhang, Camilo J Acosta, Lyn Finelli
OBJECTIVE: Among patients receiving autologous hematopoietic stem cell transplant (Auto-HSCT), we estimated the incidence of herpes zoster (HZ), compared health care costs among patients with and without HZ, and evaluated antiviral prophylaxis (AP) use. RESEARCH DESIGN AND METHODS: We conducted a retrospective study using data from a large health plan to identify patients ≥18 years with ≥1 claim for an Auto-HSCT procedure during 2006-2011 (N = 2,530). Patients were followed from date of Auto-HSCT until risk-end date, defined as development of HZ, end of enrollment, death, or 12/31/2011...
September 25, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28928210/analysis-of-individuals-from-a-dengue-endemic-region-helps-define-the-footprint-and-repertoire-of-antibodies-targeting-dengue-virus-3-type-specific-epitopes
#9
Daniela V Andrade, Leah C Katzelnick, Doug G Widman, Angel Balmaseda, Aravinda M de Silva, Ralph S Baric, Eva Harris
The four dengue virus serotypes (DENV1 to 4) cause dengue, a major public health problem worldwide. Individuals exposed to primary DENV infections develop serotype-specific neutralizing antibodies, including strongly neutralizing antibodies targeting quaternary epitopes. To date, no studies have measured the levels and kinetics of serum antibodies directed to such epitopes among populations in regions where dengue is endemic. Here, we use a recombinant DENV4 (rDENV4/3-M14) displaying a major DENV3 type-specific quaternary epitope recognized by human monoclonal antibody 5J7 to measure the proportion, magnitude, and kinetics of DENV3 type-specific neutralizing antibody responses targeting this epitope...
September 19, 2017: MBio
https://www.readbyqxmd.com/read/28920950/impact-of-a-dedicated-post-transplant-vaccination-service-at-an-australian-cancer-centre
#10
B W Teh, T Joyce, M A Slavin, K A Thursky, L J Worth
No abstract text is available yet for this article.
September 18, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28751095/a-comprehensive-review-of-immunization-practices-in-solid-organ-transplant-and-hematopoietic-stem-cell-transplant-recipients
#11
REVIEW
Pearlie P Chong, Robin K Avery
BACKGROUND: Vaccine-preventable diseases, especially influenza, varicella, herpes zoster, and invasive pneumococcal infections, continue to lead to significant morbidity and mortality in solid organ transplant (SOT) and hematopoietic stem cell transplant (HSCT) recipients. METHODS: We highlight guideline recommendations for the use of key vaccines in SOT and HSCT recipients and to review the latest evidence and developments in the field. RESULTS: Physicians should vaccinate individuals with end-stage organ disease, as vaccine seroresponse rates are higher pretransplantation...
July 24, 2017: Clinical Therapeutics
https://www.readbyqxmd.com/read/28691231/active-immunization-for-prevention-of-de-novo-hbv-infection-after-adult-living-donor-liver-transplantation-with-hbc-graft
#12
Shih-Ho Wang, Poh-Yen Loh, Ting-Lung Lin, Li-Man Lin, Wei-Feng Lee, Yu-Hung Lin, Chih-Che Lin, Chao-Long Chen
Background De novo hepatitis B infection (DNHB) may occur in recipients who do not receive prophylaxis after liver transplantation (LT) with anti-HBc(+) donor grafts. Active immunization has been shown to prevent DNHB in pediatric recipients. Our aim is to investigate the efficacy of HBV vaccination for preventing DNHB in adult living donor LT (LDLT). Patients and Methods 71 adult HBsAg(-) LDLT patients who received anti-HBc(+) grafts from 2000 to 2010 were enrolled into this study. Patients were given HBV vaccinations with the aim of achieving anti-HBs >1000 IU/L pre-transplant and >100 IU/L post-transplant...
July 10, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28677269/impact-of-a-pharmacist-led-vaccine-recommendation-program-for-pediatric-kidney-transplant-candidates
#13
Clarice E Carthon, Reed C Hall, Pamela R Maxwell, Barrett R Crowther
Pediatric transplant recipients commonly have deficient vaccination status at the time of transplantation. Utilizing transplant pharmacists to improve vaccination rates has not previously been described. This single-center, retrospective study evaluated the impact of transplant pharmacist interventions on the completion rate of vaccination schedules at time of kidney transplant. Patients who received pharmacist-led vaccination recommendations prior to transplant were compared to patients without pharmacist recommendations...
September 2017: Pediatric Transplantation
https://www.readbyqxmd.com/read/28674683/infusion-of-sibling-marrow-in-a-patient-with-purine-nucleoside-phosphorylase-deficiency-leads-to-split-mixed-donor-chimerism-and-normal-immunity
#14
Laura Yeates, Mary A Slatter, Andrew R Gennery
Purine nucleoside phosphorylase (PNP) deficiency, a rare autosomal recessive metabolic disease causes combined immunodeficiency and developmental delay, hypotonia, and spasticity. Patients present with recurrent infections associated with T-lymphocytopenia, characteristically presenting later than patients with classical severe combined immunodeficiency (SCID). PNP, with adenosine deaminase (ADA), is part of the purine salvage pathway. The only curative therapy is hematopoietic stem cell transplantation. Myeloablative conditioning is recommended to prevent rejection caused by residual immune function...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/28582321/cytomegalovirus-in-liver-transplant-recipients
#15
David Herman, Hyosun Han
PURPOSE OF REVIEW: Cytomegalovirus (CMV) is the most common opportunistic infection following solid-organ transplant and remains a cause of life-threatening disease and allograft rejection in liver transplant recipients. The purpose of this review is to highlight the current strategies in diagnosis and management of this disease in this vulnerable population. RECENT FINDINGS: Identification of high-risk individuals and aggressive treatment with antiviral agents, either via prophylaxis or by early initiation during active disease, has become the standard of care...
August 2017: Current Opinion in Organ Transplantation
https://www.readbyqxmd.com/read/28524898/influenza-adherence-tool-kit-implementation-and-evaluation-among-allogeneic-hematopoietic-transplantation-recipients%C3%A2
#16
Tracy Krimmel, Rajat Bannerji, Maribel Borysyuk, Susan M Schneider
BACKGROUND: Allogeneic transplantation is associated with significant complications, such as influenza, a common virus in the post-transplantation setting that can be detrimental to patients. Therefore, patients should adhere to influenza vaccinations.
. OBJECTIVES: The objectives of this project were to improve influenza adherence rates from 2015-2016, to increase transplantation recipients' knowledge of the importance of vaccination, and to evaluate the barriers to and facilitators of adherence rates to influenza vaccinations...
June 1, 2017: Clinical Journal of Oncology Nursing
https://www.readbyqxmd.com/read/28524832/measles-outbreak-in-pediatric-hematology-and-oncology-patients-in-shanghai-2015
#17
Yan-Ling Ge, Xiao-Wen Zhai, Yan-Feng Zhu, Xiang-Shi Wang, Ai-Mei Xia, Yue-Fang Li, Mei Zeng
BACKGROUND: Despite substantial progress toward measles control are making in China, measles outbreaks in immunocompromised population still pose a challenge to interrupt endemic transmission. This study aimed to investigate the features of measles in pediatric hematology and oncology patients and explore the reasons behind the outbreak. METHODS: We collected demographic, epidemiological, and clinical data of immunocompromised measles children. All suspected measles cases were laboratory-confirmed based on the presence of measles IgM and/or identification of measles RNA...
June 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28495643/humoral-immune-reconstitution-kinetics-after-allogeneic-hematopoietic-stem-cell-transplantation-in-children-a-maturation-block-of-igm-memory-b-cells-may-lead-to-impaired-antibody-immune-reconstitution
#18
Hisham Abdel-Azim, Amro Elshoury, Kris M Mahadeo, Robertson Parkman, Neena Kapoor
Although T cell immune reconstitution after allogeneic hematopoietic stem cell transplantation (allo-HSCT) has been well studied, long-term B cell immune reconstitution remains less characterized. We evaluated humoral immune reconstitution among 71 pediatric allo-HSCT recipients. Although tetanus toxoid antibody levels were normal at 1 year after allo-HSCT, antipolysaccharide carbohydrate antibodies remained persistently low for up to 5 years. While naive B cell counts normalized by 6 months, IgM memory B cell deficiency persisted for up to 2 years (P = ...
September 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/28460154/hepatitis-b-infection-acquired-after-haematopioetic-stem-cell-transplant-through-horizontal-mode
#19
Martin C W Chan, Frankie W T Cheng, Kin H Sze, Ann H Wong, Alex W K Leung, Paul K S Chan, Chi K Li
A 22 month old child with thalassaemia major received unrelated umbilical cord blood transplantation. She was born to mother of HBsAg carrier and received hepatitis B immunoglobulin at birth and hepatitis B vaccination. She was HBsAg negative and anti-HBs positive before transplantation. After transplant, she was taken care by her mother and found to be HBsAg positive at 2 year post-transplant. Genotyping of the mother's and child's HBV status confirmed to be of same genotype and demonstrated horizontal transmission in post-transplant setting...
April 29, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28457920/antibody-response-to-hbv-vaccination-on-dialysis-does-not-correlate-with-the-development-of-denovo-anti-hla-antibodies-after-renal-transplantation
#20
Teresa Kauke, Maximilian Link, Markus Rentsch, Manfred Stangl, Markus Guba, Joachim Andrassy, Jens Werner, Bruno Meiser, Michael Fischereder, Antje Habicht
BACKGROUND: Response to Hepatitis B virus (HBV) vaccination can be diminished in some (50-80%) but not all dialysis patients. We hypothesized, that the response to vaccination on dialysis may correlate with the development of anti-HLA antibodies after renal transplantation and might therefore be a valuable parameter to predict alloresponses. METHODS: The response to HBV vaccination on dialysis and the development of deNovo anti-HLA antibodies post-transplant was analyzed in 188 non-immunized renal transplant recipients...
June 2017: Transplant Immunology
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