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Tim Beausire, Mohamed Faouzi, Cristian Palmiere, Tony Fracasso, Katarzyna Michaud
INTRODUCTION: Ischemic heart disease (IHD) related to atherosclerotic coronary artery disease (CAD) is one of the most prevalent causes of death in Europe. Postmortem evaluation of IHD remains a challenge because of possible non-specific autopsy finding in some autopsy cases, especially in early myocardial ischemia. High-sensitive cardiac troponin T (hs-TnT) is used today in clinical practice as the "gold standard" to diagnose the myocardial ischemia, and might also be applied as an ancillary tool for post-mortem evaluation...
June 4, 2018: Forensic Science International
Zeng-Hui Diao, Jian-Jun Du, Dan Jiang, Ling-Jun Kong, Wen-Yi Huo, Cui-Mei Liu, Qi-Hang Wu, Xiang-Rong Xu
Cr6+ and Pb2+ are both highly toxic pollutants and commonly co-exist in some industrial effluents and contaminated waters. In this study, simultaneous removal of Cr6+ and Pb2+ by a novel sewage sludge-derived biochar immobilized nanoscale zero-valent iron (SSB-nZVI) was systematically investigated. It was well demonstrated that a porous structure was successfully formed on the SSB-nZVI when the starch was used as an additive. A synergistic effect on the adsorption and reduction over the SSB-nZVI was achieved, resulting in nearly 90 and 82% of Cr6+ and Pb2+ removal within 30 min, respectively...
June 13, 2018: Science of the Total Environment
Barouch Giechaskiel, Michael Clairotte, Victor Valverde-Morales, Pierre Bonnel, Zlatko Kregar, Vicente Franco, Panagiota Dilara
European regulation 2016/427 (the first package of the so-called Real-Driving Emissions (RDE) regulation) introduced on-road testing with Portable Emissions Measurement Systems (PEMS) to complement the chassis dynamometer laboratory (Type I) test for the type approval of light-duty vehicles in the European Union since September 2017. The Not-To-Exceed (NTE) limit for a pollutant is the Type I test limit multiplied by a conformity factor that includes a margin for the additional measurement uncertainty of PEMS relative to standard laboratory equipment...
June 13, 2018: Environmental Research
Tariq Khan, Bilal Haider Abbasi, Mubarak Ali Khan
Manipulation in the light regimes combined with the effects of plant growth regulators (PGRs) and elicitors through plant cell culture technology is a promising strategy for enhancing the yield of medicinally important secondary metabolites. In this study, the effects of interplay between PGRs, elicitors and light regimes on cell cultures of F. indica have been investigated. The results showed that callus cultures resulted in maximum biomass formation (13.2 g/L) when incubated on solid MS (Murashige and Skoog) medium containing 1...
June 9, 2018: Journal of Photochemistry and Photobiology. B, Biology
Filippo Mandelli, Simon Tiziani, Jürgen Schmitt, Clément M L Werner, Hans-Peter Simmen, Georg Osterhoff
BACKGROUND: A breach of the medial acetabular wall is a phenomenon seen frequently due to over-reaming during total hip arthroplasty (THA). The consequences of this issue are not fully understood particularly in cementless THA. A retrospective study was performed to answer whether: 1) immediate postoperative full-weight bearing in the presence of a medial acetabular wall breach after THA results in more short-term revisions of the acetabular component, 2) increases the risk for migration of the acetabular component? HYPOTHESIS: Immediate full-weight bearing in the presence of a medial breach is not associated with an increased likelihood for acetabular-related revision surgery or migration of the cup...
June 13, 2018: Orthopaedics & Traumatology, Surgery & Research: OTSR
Yusuf Olgar, Sinan Degirmenci, Aysegul Durak, Deniz Billur, Belgin Can, Gizem Kayki Mutlu, Ebru Arioglu Inan, Belma Turan
Aging in humans represents declining in cardio-protective systems, however its mechanisms are not known yet. We aimed to analyse how aging affects key mechanisms responsible for contractile dysfunction via comparing the improperly synchrony between electrical and mechanical activities in male aged-rats (24-month old) comparison to those of adult-rats (6-month old). We determined significantly increased systemic oxidative stress with decreased antioxidant capacity, clear insulin resistance and hypertrophy in aged-rats with normal fasting blood glucose...
June 13, 2018: Experimental Gerontology
Wen-Ju Pan, Seung Yup Lee, Jacob Billings, Maysam Nezafati, Waqas Majeed, Erin Buckley, Shella Keilholz
Optical studies of ex vivo brain slices where blood is absent show that neural activity is accompanied by significant intrinsic optical signals (IOS) related to activity-dependent scattering changes in neural tissue. However, the neural scattering signals have been largely ignored in vivo in widely-used IOS methods where absorption contrast from hemoglobin was employed. Changes in scattering were observed on a time scale of seconds in previous brain slice IOS studies, similar to the time scale for the hemodynamic response...
June 13, 2018: NeuroImage
Noémi Papp, Szilvia Vas, Emese Bogáthy, Zita Kátai, Diána Kostyalik, György Bagdy
Brain oscillations in the gamma frequency band of the electroencephalogram (EEG) have been implicated in several sensory and cognitive processes, and have also been associated with numerous neuropsychiatric disorders, including depression. The widely prescribed selective serotonin reuptake inhibitors (SSRIs), similarly to other antidepressants, are known to produce markedly different effects on sleep and behavioral measures with acute and chronic administration. Although there are studies examining the acute effect of escitalopram on slower (<30 Hz) oscillations, we hardly could find any data about the effect of the drug on higher-frequency EEG oscillations (>30 Hz) in different sleep-wake stages, particularly comparing the acute and chronic effects of the drug concerning gamma oscillations...
June 13, 2018: European Journal of Pharmaceutical Sciences
Nannan Song, Zhilan Xu, Jing Wang, Qianqian Qin, Haiyang Jiang, Weina Si, Xiaoyu Li
The CONSTANS-LIKE (COL) gene has an important role both in regulation flowering through photoperiodic control and response to abiotic stress. In the present study, we performed a genome-wide analysis of maize COL gene family and identified 19 non-redundant ZmCOL genes, which were unequally distributed on ten maize chromosomes. Analysis of compound phylogenetic tree (maize, sorghum, rice and Arabidopsis) showed high bootstrap, as well as conserved domain and semblable gene structures among members within the same clade, revealing that COL genes in same clade were from the common ancestral and prior to the divergence of monocots and dicots lineages...
June 13, 2018: Gene
Zhengfei Wang, Ziqian Wang, Xuejia Shi, Qiong Wu, Yitao Tao, Huayun Guo, Chenyao Ji, Yuze Bai
In this study, the complete mitochondrial DNA (mtDNA) sequence of the crab Parasesarma affine is determined, characterized and compared with other decapod crustaceans. The P. affine mitochondrial genome (mitogenome) is 15,638 bp in size, and contains 13 protein-coding genes (PCGs), 2 ribosomal RNA (rRNA) genes, 22 transfer RNA (tRNA) genes and a control region (CR). Then, 23 of the 37 genes are encoded by the heavy (+) strand while 14 are encoded by the light (-) strand. All PCGs are initiated by ATN codons and 4 of the 13 PCGs harbored the incomplete termination codon by T or TA...
June 13, 2018: International Journal of Biological Macromolecules
Mayson H Alkhatib, Waad A Al-Otaibi, Abdulwahab Noor Wali
Combining the essential oils (ESSOs) with the chemotherapeutic agent, mitomycin C (MMC), in nanoparticle can be beneficial in cancer therapy. The aim of the current study was to in vitro evaluate the antineoplastic effect of MMC, formulated in two different nanoemulsions (NE) based on two ESSOs, chamomile (Ch) and garlic (Gar), on HeLa cervical cancer cells. The z-average diameter of Ch-NE has slightly increased from 83.39 ± 12.85 nm to 91.18 ± 5.79 nm when mixed with MMC (Ch-MMC) whereas the z-average diameter of Gar-NE has markedly increased from 50...
June 13, 2018: Chemico-biological Interactions
Vibor Laketa
A comprehensive understanding of host-pathogen interactions requires quantitative assessment of molecular events across a wide range of spatiotemporal scales and organizational complexities. Due to recent technical developments, this is currently only achievable with microscopy. This article is providing a general perspective on the importance of microscopy in infectious disease research, with a focus on new imaging modalities that promise to have a major impact in biomedical research in the years to come. Every major technological breakthrough in light microscopy depends on, and is supported by, advancements in computing and information technologies...
June 13, 2018: Journal of Molecular Biology
Cristina Meregalli, Giulia Fumagalli, Paola Alberti, Annalisa Canta, Valentina Alda Carozzi, Alessia Chiorazzi, Laura Monza, Eleonora Pozzi, Åsa Sandelius, Kaj Blennow, Henrik Zetterberg, Paola Marmiroli, Guido Cavaletti
The objective of this study is to test the feasibility of using serum neurofilament light chain (NfL) as a disease biomarker in Chemotherapy Induced Peripheral Neuropathy (CIPN) since this easy accessible biological test may have a large impact on clinical management and safety of cancer patients. We performed this preclinical study using a well-characterized rat model based on repeated administration of the cytostatic drug vincristine (VCR, 0.2 mg/kg intravenously via the tail vein once/week for 4 times)...
June 13, 2018: Experimental Neurology
Ila Mishra, Neha Agarwal, Sangeeta Rani, Vinod Kumar
Circannual rhythm regulates annual timing of reproduction in spotted munia, with sex-differences in its relationship with the external photoperiod environment. Interestingly, munia show an atypical photosensitivity and exhibit gonadal maturation when acutely exposed to an unnatural short photoperiod (e.g. 3 h light per day; i.e. a long scotoperiod). The proximate mechanisms regulating scotoperiod-induced hypothalamus-pituitary-gonadal (HPG) activation are unclear. Since thyroid hormone signalling plays a central role in photoperiodic induction, we hypothesized the involvement of similar mechanism, i...
June 16, 2018: Journal of Neuroendocrinology
Benjamin Gille, Maxim De Schaepdryver, Janne Goossens, Lieselot Dedeene, Joke De Vocht, Emanuela Oldoni, An Goris, Ludo Van Den Bosch, Bart Depreitere, Kristl G Claeys, Jos Tournoy, Philip Van Damme, Koen Poesen
AIMS: Amyotrophic Lateral Sclerosis (ALS) is the most common motor neuron degeneration disease with a diagnostic delay of about one year after symptoms onset. In ALS, blood neurofilament light chain (NfL) levels are elevated, but it is not entirely clear what drives this increase and what the diagnostic performance of serum NfL is in terms of predictive values and likelihood ratios. The aims of this study were to further explore the prognostic and diagnostic performances of serum NfL to discriminate between patients with ALS and ALS mimics, and to investigate the relationship between serum NfL with motor neuron degeneration...
June 16, 2018: Neuropathology and Applied Neurobiology
Mozhgan Aghajanzadeh, Mostafa Zamani, Hamid Rashidzadeh, Kobra Rostamizadeh, Ali Sharafi, Hossein Danafar
In this project, a core-shell Polymersome based on miktoarm star-copolymer: methoxy Poly Ethylene Glycol-Lysine-(Poly Caprolactone)2 (PEG-Lys-PCL2 ) was synthesized by a new method as controlled targeted drug delivery systems for co-delivery of the chemotherapeutic methotrexate (MTX) and curcumin (CUR). Some properties of these nano carriers (NCs) such as surface morphology, structure, surface charge, stability and biocompatibility were evaluated by Proton nuclear magnetic resonance (1 HNMR), dynamic scanning colorimetry (DSC), Fourier-transform infrared spectroscopy (FT-IR), Dynamic light scattering (DLS), atomic force microscopy (AFM), Critical aggregation concentration (CAC), hemolysis test, MTT assay and lethal dose 50 (LD50)...
June 16, 2018: Journal of Biomedical Materials Research. Part A
Wathiq Sattar Abdul-Hassan, Denis Roux, Christophe Bucher, Saioa Cobo, Florian Molton, Eric Saint-Aman, Guy Royal
We report the study of stimuli-responsive Zn(II) and Fe(II) coordination polymers (MC34+ or MC24+ with M = Fe2+ or Zn2+). These soluble metallopolymers were formed spontaneously by reaction of an organic ligand (C34+ or C24+) with one molar equivalent of metal ions. The C34+ and C24+ ligands incorporate two chelating terpyridine groups bridged by a redox responsive hinge featuring two viologen units (viologen = N,N'-dialkyl-4,4'-bipyridinium) linked either through propyl (C34+) or ethyl (C24+) chains. The viologen units in the polymer chains were reduced (1e per viologen group) either by bulk electrolysis or by visible-light irradiation carried out in the presence of a photosensitizer...
June 15, 2018: Chemistry: a European Journal
Jin Young Bae, Cheol Ju Mun, Yun Sook Kim, Dong Kuk Ahn, Yong Chul Bae
Parvalbumin (PV), calretinin (CR), calbindin D-28k (CB), stage specific embryonic antigen-4 (SSEA4), and phosphorylated neurofilament 200 (pNF200) have been commonly used as markers for primary afferent neurons with large myelinated (A) fibers but detailed information on the expression of these markers in specific primary afferent fiber types is still lacking. We here examined the fibers that express PV, CR, CB, SSEA4, and pNF200 in the trigeminal ganglion and its peripheral sensory root by light- and electron-microscopic immunohistochemistry and quantitative analysis...
June 15, 2018: Journal of Comparative Neurology
Nicholas V Sarlis, Efthimios S Skordas, Apostolis Mintzelas, Konstantina A Papadopoulou
The magnitude time-series of the global seismicity is analyzed by the empirical mode decomposition giving rise to 14 intrinsic mode functions (IMF) and a trend. Using Hurst analysis one can identify three different sums of these IMFs and the trend which exhibit distinct multifractal behaviour and correspond to micro-, mid- and macro-scales. Their multifractal detrended fluctuation analysis reveals that the micro-scale time-series exhibits anticorrelated behaviour in contrast to the mid-scale one which is long-range correlated...
June 15, 2018: Scientific Reports
Simona Bussotti, Antonio Di Franco, Carlo Nike Bianchi, Pierre Chevaldonné, Lea Egea, Emanuela Fanelli, Christophe Lejeusne, Luigi Musco, Carlos Navarro-Barranco, Alexis Pey, Serge Planes, Jean Vincent Vieux-Ingrassia, Paolo Guidetti
Dark marine habitats are often characterized by a food-limited condition. Peculiar dark habitats include marine caves, characterized by the absence of light and limited water flow, which lead to reduced fluxes of organic matter for cave-dwelling organisms. We investigated whether the most abundant and common cave-dwelling fish Apogon imberbis has the potential to play the role of trophic vector in Mediterranean marine caves. We first analysed stomach contents to check whether repletion changes according to a nycthemeral cycle...
June 15, 2018: Scientific Reports
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