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https://www.readbyqxmd.com/read/28651421/-effects-of-change-in-the-activity-of-vacuolar-adenosine-triphosphatase-of-myocardial-lysosome-on-myocardial-damage-in-rats-after-severe-burn-and-its-mechanism
#1
X P Yan, D X Zhang, T T Yan, Q Zhang, J Z Jia, Y S Huang
Objective: To explore the effects of change of activity of vacuolar adenosine triphosphatase (V-ATPase) of myocardial lysosome on myocardial damage in rats after severe burn and its mechanism. Methods: The myocardial lysosomes were extracted from the hearts of 12 SD rats with ultra-high speed gradient density centrifugation, then Western blotting and transmission electron microscope observation were conducted for identification. One hundred and twenty rats were divided into pure burn group, ATP group, normal control group, and bafilomycin group according to the random number table, with 30 rats in each group...
May 20, 2017: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/28651310/clinicopathological-characteristics-of-extremely-young-korean-multiple-myeloma-patients-therapeutic-implications
#2
Junghoon Shin, Youngil Koh, Jeonghwan Youk, Miso Kim, Byung Soo Kim, Chul Won Choi, Hwa Jung Sung, Yong Park, Sung-Soo Yoon, Inho Kim
Background/Aims: Although multiple myeloma (MM) is typically a disease of the elderly, a certain subset of extremely young patients exists. It is necessary to establish clinicopathological characteristics for this population. Methods: We reviewed the medical records of MM patients whose age was 40 years or younger at diagnosis. Results: A total of 32 patients were analyzed (male to female ratio 19:13, median age 37 years). According to International Staging System, 29%, 48%, and 16% were in stage I, II, and III, respectively...
June 26, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28651226/insight-in-body-dysmorphic-disorder-bdd-relative-to-obsessive-compulsive-disorder-ocd-and-psychotic-disorders-revisiting-this-issue-in-light-of-dsm-5
#3
Wei Lin Toh, David J Castle, Rachel L Mountjoy, Ben Buchanan, John Farhall, Susan L Rossell
INTRODUCTION: In DSM-5, body dysmorphic disorder (BDD) was reclassified under the obsessive-compulsive and related disorders (OCRDs), but little is known about the nature of BDD beliefs. This study aimed to compare level of insight in BDD and consider related implications for DSM-5 classification. METHOD: Participants were 27 BDD, 19 obsessive-compulsive disorder (OCD), and 20 psychosis (SZ) participants as well as 42 non-clinical controls (NC), who completed the Brown Assessment of Beliefs Scale (BABS) and Peters Delusions Inventory (PDI)...
June 8, 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/28651206/an-investigation-of-the-role-of-defect-levels-on-the-radiation-response-of-synthetic-diamond-crystals-when-used-as-sensors-for-the-detection-of-mammography-x-rays
#4
Nicholas Ade
This study evaluates the role of defects on the performances of synthetic diamond sensors on exposure to mammography X-rays. Through systematic investigations, the main cause of instability of response of examined sensors necessitating pre-irradiation was isolated and ascribed to the presence of ambient light which has the effect of emptying shallow trapping levels. The changes in response between measurements in light and dark conditions varied from 2.8 ± 1.2% to 63.0 ± 0.3%. Sensitivities between 0.4 and 6...
June 17, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28651205/understanding-size-dependent-properties-of-biocl-nanosheets-and-exploring-more-catalysis
#5
Benxia Li, Liangzhi Shao, Baoshan Zhang, Renshan Wang, Mei Zhu, Xiaowei Gu
Investigating the dependence of the catalysis on the size and structure of materials is of great significance for exploiting catalysts with characteristics of high activity, low cost, and new property. Non-precious metal catalysts bear high hope to meet the increasing demands of industrial applications in a cost-effective and environmentally friendly way. In this work, we take size-controlled BiOCl nanosheets as examples, which are synthesized via a hydrothermal method by changing the reaction conditions. The BiOCl nanosheets were characterized in details to understand their size-property relationships, and were found to exhibit a series of thickness-dependent physicochemical properties, including specific surface area, light absorption, and the separation efficiency of photo-generated charge carriers...
June 20, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28651185/treatment-of-neurocognitive-symptoms-in-unipolar-depression-a-systematic-review-and-future-perspectives
#6
REVIEW
E Salagre, B Solé, Y Tomioka, B S Fernandes, D Hidalgo-Mazzei, M Garriga, E Jimenez, J Sanchez-Moreno, E Vieta, I Grande
BACKGROUND: Cognitive symptoms in Major Depressive Disorder (MDD) are persistent and commonly entail neurocognitive impairment and a decline in quality of life. This systematic review gathers the current scientific evidence on therapeutic strategies for neuropsychological impairment in MDD. METHOD: A systematic search on PubMed, PsycINFO and Clinicaltrials.gov was carried out on December 2016 according to PRISMA using Boolean terms to identify interventions for the treatment of cognitive dysfunction in MDD...
June 19, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28651104/autophagy-is-an-important-event-for-low-dose-cytarabine-treatment-in-acute-myeloid-leukemia-cells
#7
Liyun Chen, Pei Guo, Yunxiang Zhang, Xiaoyang Li, Peimin Jia, Jianhua Tong, Junmin Li
Cytarabine (Ara-c) has been an important agent in acute myeloid leukemia (AML) treatment for more than 40 years. While, the mechanisms underlying low dose cytarabine (LD Ara-c) is poorly understood. In this study, we investigated the therapeutic effect of LD Ara-C in vitro. U937 and HEL cell lines were treated with increasing dose of Ara-C and showed growth inhibition rates in a time and dose-dependent manner. Treatment with LD Ara-C (50nM) induced a time-dependent increase in expression of microtubule-associated protein light chain 3 (LC3) and beclin1, but degradation of sequestosome1 (p62) in both U937 and HEL cells...
June 16, 2017: Leukemia Research
https://www.readbyqxmd.com/read/28651076/application-of-water-assisted-ultraviolet-light-in-combination-of-chlorine-and-hydrogen-peroxide-to-inactivate-salmonella-on-fresh-produce
#8
Shuanghuan Guo, Runze Huang, Haiqiang Chen
With the demand for fresh produce increases in recent decades, concerns for microbiological safety of fresh produce are also raised. To identify effective ultraviolet (UV) light treatment for fresh produce decontamination, we first determined the effect of three forms of UV treatment, dry UV (samples were treated by UV directly), wet UV (samples were dipped in water briefly and then exposed to UV), and water-assisted UV (samples were treated by UV while being immersed in agitated water) on inactivation of Salmonella inoculated on tomatoes and fresh-cut lettuce...
June 19, 2017: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/28651057/how-to-identify-plasmons-from-the-optical-response-of-nanostructures
#9
Runmin Zhang, Luca Bursi, Joel D Cox, Yao Cui, Caroline M Krauter, Alessandro Alabastri, Alejandro Manjavacas, Arrigo Calzolari, Stefano Corni, Elisa Molinari, Emily A Carter, F Javier Garcia de Abajo, Hui Zhang, Peter Nordlander
A promising trend in plasmonics involves shrinking the size of plasmon-supporting structures down to a few nanometers, thus enabling control over light-matter interaction at extreme-subwavelength scales. In this limit, quantum-mechanical effects, such as nonlocal screening and size quantization, strongly affect the plasmonic response, rendering it substantially different from classical predictions. For very small clusters and molecules, collective plasmonic modes are hard to distinguish from other excitations such as single-electron transitions...
June 26, 2017: ACS Nano
https://www.readbyqxmd.com/read/28651054/importance-and-nature-of-short-range-excitonic-interactions-in-light-harvesting-complexes-and-organic-semiconductors
#10
Rocco Peter Fornari, Patrick Rowe, Daniele Padula, Alessandro Troisi
The singlet excitonic coupling between many pairs of chromophores is evaluated in three different Light Harvesting Complexes (LHCs) and two organic semiconductors (amorphous and crystalline). This large database of structures is used to assess the relative importance of short-range (exchange, overlap, orbital) and long-range (Coulombic) excitonic coupling. We find that atomic transition charges can introduce systematic errors on the Coulombic coupling and that the dipole-dipole interaction fails to capture the true Coulombic coupling even at intermolecular distances of up to 50 Å...
June 26, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/28651050/brillouin-oscillations-from-single-au-nanoplate-opto-acoustic-transducers
#11
Kuai Yu, Tuphan Devkota, Gary Beane, Guo Ping Wang, Gregory V Hartland
Brillouin oscillations, which are GHz frequency waves that arise from the interaction of light with acoustic waves, are experiencing increasing applications in biology and materials science. They provide information about the speed of sound in the material they propagate in, and have recently been used in imaging applications. In the current study Brillouin oscillations in glass, water and polymer (PMMA) are observed through ultrafast transient reflectivity measurements using chemically synthesized Au nanoplates as opto-acoustic transducers...
June 26, 2017: ACS Nano
https://www.readbyqxmd.com/read/28651045/photoinduced-charge-transfer-versus-fragmentation-pathways-in-lanthanum-cyclopentadienyl-complexes
#12
Yulun Han, Qingguo Meng, Bakhtiyor Rasulev, P Stanley May, Mary T Berry, Dmitri S Kilin
This study compares two competing pathways of photoexcitations in gas-phase metal-organic complexes: first, a sequence of phonon-assisted electronic transitions leading to dissipation of the energy of photoexcitations and second, a sequence of light-driven electronic transitions leading to photolysis. Phonon-assisted charge carrier dynamics is investigated by combination of the density matrix formalism and on-the-fly nonadiabatic couplings. Light-driven fragmentation is modeled by a time-dependent excited-state molecular dynamics (TDESMD) algorithm based on Rabi theory and principles similar to the trajectory surface hopping approximation...
June 26, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/28651035/material-efficient-microfluidic-platform-for-exploratory-studies-of-visible-light-photoredox-catalysis
#13
Connor W Coley, Milad Abolhasani, Hongkun Lin, Klavs F Jensen
We present an automated microfluidic platform for in-flow studies of visible-light photoredox catalysis in liquid or gas-liquid reactions at the 15 μL scale. An oscillatory flow strategy enables flexible residence time while preserving the mixing and heat transfer advantages of flow systems. The adjustable photon flux possible with the platform is characterized using actinometry. Case studies of oxidative hydroxylation of phenylboronic acids and dimerization of thiophenol demonstrate the capabilities and advantages of the system...
June 26, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28651016/enhanced-light-microscopy-visualization-of-virus-particles-from-zika-virus-to-filamentous-ebolaviruses
#14
George G Daaboul, David S Freedman, Steven M Scherr, Erik Carter, Alexandru Rosca, David Bernstein, Chad E Mire, Krystle N Agans, Thomas Hoenen, Thomas W Geisbert, M Selim Ünlü, John H Connor
Light microscopy is a powerful tool in the detection and analysis of parasites, fungi, and prokaryotes, but has been challenging to use for the detection of individual virus particles. Unlabeled virus particles are too small to be visualized using standard visible light microscopy. Characterization of virus particles is typically performed using higher resolution approaches such as electron microscopy or atomic force microscopy. These approaches require purification of virions away from their normal millieu, requiring significant levels of expertise, and can only enumerate small numbers of particles per field of view...
2017: PloS One
https://www.readbyqxmd.com/read/28650999/an-ancestral-haplotype-of-the-human-period2-gene-associates-with-reduced-sensitivity-to-light-induced-melatonin-suppression
#15
Tokiho Akiyama, Takafumi Katsumura, Shigeki Nakagome, Sang-Il Lee, Keiichiro Joh, Hidenobu Soejima, Kazuma Fujimoto, Ryosuke Kimura, Hajime Ishida, Tsunehiko Hanihara, Akira Yasukouchi, Yoko Satta, Shigekazu Higuchi, Hiroki Oota
Humans show various responses to the environmental stimulus in individual levels as "physiological variations." However, it has been unclear if these are caused by genetic variations. In this study, we examined the association between the physiological variation of response to light-stimulus and genetic polymorphisms. We collected physiological data from 43 subjects, including light-induced melatonin suppression, and performed haplotype analyses on the clock genes, PER2 and PER3, exhibiting geographical differentiation of allele frequencies...
2017: PloS One
https://www.readbyqxmd.com/read/28650979/expression-of-cerebral-serotonin-related-to-anxiety-like-behaviors-in-c57bl-6-offspring-induced-by-repeated-subcutaneous-prenatal-exposure-to-low-dose-lipopolysaccharide
#16
Pei-Tan Hsueh, Hsuan-Han Wang, Chiu-Lin Liu, Wei-Fen Ni, Ya-Lei Chen, Jong-Kang Liu
Prenatal exposure to lipopolysaccharide (LPS), which likely occurs due to infection or contact with environmental allergens during pregnancy, is a proposed risk factor that induces anxiety- and autism spectrum disorder-like behaviors in offspring. However, the molecular and behavioral changes in offspring after maternal immune activation have not been completely identified. We hypothesized that a subcutaneous injection of LPS in a pregnant mouse would induce changes in cerebral serotonin (5-HT) in parallel to the appearance of anxiety-like behaviors in the dam's offspring...
2017: PloS One
https://www.readbyqxmd.com/read/28650927/dexamethasone-prevents-lipopolysaccharide-induced-epithelial-barrier-dysfunction-in-rat-ileum
#17
Aline Barbosa Ribeiro, Humberto Giusti, Ana Paula Trevelin Souza, Celso Rodrigues Franci, Rafael Simone Saia
Inflammatory mediators have been postulated as elementary inducing factors to the disruption of the intestinal tight junctions (TJ) and consequently, gut permeability and bacterial translocation. Corticosteroids are considered the mainstay in the treatment of septic shock; however the impact of this therapy on the intestinal epithelial barrier dysfunction during septic shock remains unknown. Our aims were to demonstrate the role of low dexamethasone (DEX) doses in modulation of the inflammatory response, as well as the expression and the arrangement of TJ proteins in endotoxemic rats...
June 23, 2017: Shock
https://www.readbyqxmd.com/read/28650864/metabolic-syndrome-and-sexual-dysfunction
#18
Michael L Schulster, Sydney E Liang, Bobby B Najari
PURPOSE OF REVIEW: To describe the connection between metabolic syndrome and male sexual dysfunction. RECENT FINDINGS: Concurrent with the obesity epidemic, metabolic syndrome in the United States is reaching crisis levels. A myriad of comorbidities are rising as well, affecting cost and quality of life. Sexual dysfunction is one of these comorbidities, with an extremely high prevalence, which will only increase as the population ages.In light of this ubiquity, recent research has explored the mechanisms of decreased libido, hypogonadism and erectile dysfunction through the lens of metabolic syndrome and its individual components...
June 24, 2017: Current Opinion in Urology
https://www.readbyqxmd.com/read/28650685/colored-glasses-to-mitigate-photophobia-symptoms-posttraumatic-brain-injury
#19
Joseph Clark, Kim Hasselfeld, Katy Bigsby, Jon Divine
CONTEXT:   After a concussion or mild traumatic brain injury (mTBI), patients often suffer from light sensitivity, or photophobia, which contributes to decreased quality of life post-mTBI. Whereas sunglasses may provide some relief from photophobia, they are not practical indoors or in low light. A light-mitigation strategy that can be easily used indoors as needed to optimize the relief. We have found that many photophobic patients experience relief using colored sunglasses. OBJECTIVE:   To provide the athletic trainer with a means and method to assess whether an athlete is suffering from photophobia after concussion and to determine if colored glasses provide relief...
June 26, 2017: Journal of Athletic Training
https://www.readbyqxmd.com/read/28650666/labile-incorporation-of-cholesterol-terminated-poly-acrylic-acid-for-the-facile-surface-modification-of-lipid-vesicles
#20
Sang-Min Lee
An amphiphilic cholesterol-terminated poly[acrylic acid] (Chol-PAA) that can be self-aggregated into nanoscale micelles in aqueous media has been prepared via nitroxide-mediated radical polymerization for the facile postformation modification of lipid vesicles. By varying the amount of Chol-PAA addition, the incorporation of Chol-PAA on the liposome templates was verified with zeta potential while the dynamic light scattering measurements revealed the polymer length of Chol-PAA dictated the hydrodynamic diameter of the resulting polymer-grafted vesicles (PGVs)...
June 26, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
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