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Good Clinical Practices

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https://www.readbyqxmd.com/read/29679141/ethical-considerations-of-researchers-conducting-pediatric-clinical-drug-trials-a-qualitative-survey-in-two-belgian-university-children-s-hospitals
#1
Wannes Van Hoof, Kevin Meesters, Lien Dossche, Daphné Christiaens, Pauline De Bruyne, Johan Vande Walle
There is a general consensus about the underlying theoretical ethical principles that ground the practice of pediatric clinical trials: scientific necessity, good risk/benefit ratio, minimized burden, and parental consent/child assent. However, these principles are so broadly construed that it is not always clear how they should be applied in clinical practice. We conducted a qualitative study at Ghent University Hospital and the hospital of the Dutch-speaking university of Brussels on how researchers weigh ethical principles, assess the risk/benefit balance, estimate patient experience, and experience informed consent procedures in pediatric drug studies...
April 21, 2018: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29679132/-self-reported-vision-in-gerontological-health-services-research-and-practice-an-opening-plea
#2
REVIEW
J Köberlein-Neu, A Seifert, I Himmelsbach
The use of self-reported vision is an integral part of most population surveys and is primarily used for healthcare monitoring. Since the patient's assessment is not always consistent with the objectively measured clinical parameters, the majority of the literature looks critically at the adequacy of self-reported vision, particularly with respect to answering epidemiological questions; however, it is often misunderstood that self-reported vision measures far more than the directly derived information show...
April 20, 2018: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/29679116/arthroscopic-treatment-for-intratendinous-rotator-cuff-tear-results-in-satisfactory-clinical-outcomes-and-structural-integrity
#3
Sang Jin Cheon, Hyo Yeol Lee, Woong Ki Jeon
PURPOSE: This study aimed to evaluate the clinical outcomes and structural integrity of arthroscopic repair of intratendinous rotator cuff tear. METHODS: Patients who were diagnosed with an intratendinous tear but in whom conservative treatment failed were selected and underwent arthroscopic repair. Between 2008 and 2014, a total of 30 patients (6 men, 24 women; mean age, 59 ± 3.7 years) met the inclusion criteria and were followed up. The mean follow-up period was 26...
April 20, 2018: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29678987/protocol-for-a-phase-iii-non-inferiority-randomised-comparison-of-a-new-fibrinogen-concentrate-versus-cryoprecipitate-for-treating-acquired-hypofibrinogenaemia-in-bleeding-cardiac-surgical-patients-the-fibres-trial
#4
Keyvan Karkouti, Jeannie Callum, Vivek Rao, Nancy Heddle, Michael E Farkouh, Mark A Crowther, Damon C Scales
INTRODUCTION: Coagulopathic bleeding is a serious complication of cardiac surgery to which an important contributor is acquired hypofibrinogenaemia (plasma fibrinogen <1.5-2.0 g/L). The standard intervention for acquired hypofibrinogenaemia is cryoprecipitate, but purified fibrinogen concentrates are also available. There is little comparative data between the two therapies and randomised trials are needed. METHODS AND ANALYSIS: FIBrinogen REplenishment in Surgery (FIBRES) is a multicentre, randomised (1:1), active-control, single-blinded, phase III trial in adult cardiac surgical patients experiencing clinically significant bleeding related to acquired hypofibrinogenaemia...
April 20, 2018: BMJ Open
https://www.readbyqxmd.com/read/29678379/desquamative-gingivitis-diagnosis-and-treatment
#5
REVIEW
Andrea D Maderal, Paul Lee Salisbury, Joseph L Jorizzo
Desquamative gingivitis is a clinical finding with several potential etiologies, and therefore histologic examination should be performed to confirm the diagnosis before the implementation of systemic therapy. The best methods for obtaining a mucosal biopsy specimen are discussed to aid the dermatologist in approaching these patients, and indications for additional testing, such as immunofluorescence studies, are reviewed. Desquamative gingivitis is uncommon, and there are no systematic guidelines to assist the physician in treatment, producing a practice gap in management...
May 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29678333/small-animal-neonatal-health
#6
REVIEW
Robyn R Wilborn
Although most veterinarians have been caring for neonates successfully for several years, it is often good to review our methods and aim to incorporate new practices that will increase survivability, especially of the weaker neonates. These tips are easy to incorporate and do not require radical change by the doctors or staff. Armed with some key pearls of neonatal knowledge and basic clinical skills, one can successfully prevent and treat the most common clinical presentations of neonatal puppies and kittens...
April 17, 2018: Veterinary Clinics of North America. Small Animal Practice
https://www.readbyqxmd.com/read/29678037/semi-automatically-measuring-shoulders-range-of-motion-objective-measurements-with-good-reliability-and-accuracy
#7
Birgit Saalfeld, Ilonka Pingel, Klaus-Hendrik Wolf
The shoulder's range of motion (ROM) is an important measurement for the diagnostic process and course of treatment for patients with shoulder disorders or injuries. Visual estimation to assess a shoulder's ROM is a fast measuring method, and therefore routinely used in clinical practice. Studies already proved this method as very subjective and unreliable. Misestimating the severity of a patient's disability can lead to improper treatment and should be avoided. Modern technology may help measuring the ROM more reliable, objective, non-invasive and still fast...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29677010/rasch-analysis-of-the-9-item-shared-decision-making-questionnaire-in-women-with-breast-cancer
#8
Tzu-Yi Wu, Cheng-Te Chen, Yi-Jing Huang, Wen-Hsuan Hou, Jung-Der Wang, Ching-Lin Hsieh
BACKGROUND: Shared decision making (SDM) is a best practice to help patients make optimal decisions by a process of healthcare, especially for women diagnosed with breast cancer and having heavy burden in long-term treatments. To promote successful SDM, it is crucial to assess the level of perceived involvement in SDM in women with breast cancer. OBJECTIVE: The aims of this study were to apply Rasch analysis to examine the construct validity and person reliability of the 9-item Shared Decision Making Questionnaire (SDM-Q-9) in women with breast cancer...
April 19, 2018: Cancer Nursing
https://www.readbyqxmd.com/read/29676111/-research-progress-on-quality-evaluation-of-salviae-miltiorrhizae-radix-et-rhizoma-danshen
#9
REVIEW
Wen-Tao Fang, Ai-Ping Deng, Zhen-Li Ren, Tie-Gui Nan, Li-Ping Kang, Lan-Ping Guo, Lu-Qi Huang, Zhi-Lai Zhan
Salviae Miltiorrhizae Radix et Rhizoma (Danshen) is one of the commonly used bulk medicinal materials in China. It is widely used in clinical practice, and has many pharmacological effects, such as antithrombotic,antibacterial,anti-inflammatory,anti-oxidative and immunomodulatory activities. The quality of Danshen determines the quality of the curative effect. The current wild resources of Danshen gradually decrease, the cultivation area is widely distributed, among them, Shandong, Sichuan, Anhui, Shanxi, Hebei, Henan and other provinces have large acreage for Danshen...
March 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29675390/childhood-glaucoma-profile-in-dakahelia-egypt-a-retrospective-study
#10
Tharwat H Mokbel, Eman M El Hefney, Sherein M Hagras, Ahmed A ALNagdy, Amani E Badawi, Manal A Kasem, Shereen M El Shaer
AIM: To analyze childhood glaucoma regarding its demographics, presentations, different causes and surgical modalities used among patients in Dakahelia and to apply the Childhood Glaucoma Research Network (CGRN) classification retrospectively to evaluate its convenience. METHODS: A retrospective study in which the medical files of all glaucoma patients <16 years old presented to Mansoura Ophthalmic Center, Mansoura University from 2014 to 2017, were retrieved and analyzed...
2018: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/29675096/nomograms-to-predict-individual-prognosis-of-patients-with-primary-small-cell-carcinoma-of-the-bladder
#11
Fan Dong, Yifan Shen, Fengbin Gao, Xiao Shi, Tianyuan Xu, Xianjin Wang, Xiaohua Zhang, Shan Zhong, Minguang Zhang, Shanwen Chen, Zhoujun Shen
Objectives: To develop reliable nomograms to estimate individualized overall survival (OS) and cancer specific survival (CSS) for patients with primary small cell carcinoma of the bladder (SCCB) and compare the predictive value with the AJCC stages. Patients and Methods: 582 eligible SCCB patients identified in the Surveillance, Epidemiology, and End Results (SEER) dataset were randomly divided into training (n=482) and validation (n=100) cohorts. Akaike information criterion was used to select the clinically important variables in multivariate Cox models when establishing nomograms...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29674329/regional-variability-in-fecal-microbiota-transplantation-practices-a-survey-of-the-southern-ontario-fecal-microbiota-transplantation-movement
#12
Susy S Hota, Salman Surangiwala, Aimee S Paterson, Bryan Coburn, Susan M Poutanen
BACKGROUND: There is growing evidence that fecal microbiota transplantation (FMT) is an effective treatment for recurrent Clostridium difficile infection, but little guidance exists for implementation of FMT programs. The objective of this study is to describe the program characteristics and protocols of 9 planned or operating FMT programs in the Southern Ontario Fecal Microbiota Transplantation (SOFT) Movement, to help guide future FMT program implementation. METHODS: A 59-item survey was administered electronically to clinical leads of the SOFT Movement on June 2, 2016...
April 18, 2018: CMAJ Open
https://www.readbyqxmd.com/read/29673984/bioinformatics-analysis-and-epitope-screening-of-a-potential-vaccine-antigen-tolb-from-acinetobacter-baumannii-outer-membrane-protein
#13
Xiaojie Song, Hua Zhang, Dongsheng Zhang, Weifeng Xie, Guanghui Zhao
The clinical isolation rate of multidrug-resistant or pan-resistant Acinetobacter baumannii (A. baumannii) is increasing, resulting that optional antibiotics are very limited in clinical practice. To deal with such a dilemma in treatment, the development of effective vaccines serves as a good strategy. Outer membrane proteins (Omp) often contain potential excellent vaccine antigens, and NCBI has published >300 Omp sequences of A. baumannii (including the duplicates). To accurately screen out the potential excellent antigen molecules from a large number of sequences, and avoid repetitive experimental processes is of great significance...
April 16, 2018: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/29670989/evaluation-of-the-perception-of-clinical-competencies-by-nursing-students-in-the-different-clinical-settings-an-observational-study
#14
I Notarnicola, A Stievano, A Pulimeno, L Iacorossi, A Petrizzo, F Gambalunga, G Rocco, C Petrucci, L Lancia
INTRODUCTION: The university educational sphere has many dilemmas. The question of sufficient knowledge and skills for students to acquire abilities to provide care in different clinical setting is one important dilemma. AIM: To measure the level of competencies by nursing students and its application in different clinical environments. METHODS: Nursing students of two Italian universities participated in the research. Data collection took place April to July 2015 using the Nurse Competence Scale...
May 2018: Annali di Igiene: Medicina Preventiva e di Comunità
https://www.readbyqxmd.com/read/29669940/generation-and-testing-of-clinical-grade-exosomes-for-pancreatic-cancer
#15
Mayela Mendt, Sushrut Kamerkar, Hikaru Sugimoto, Kathleen M McAndrews, Chia-Chin Wu, Mihai Gagea, Sujuan Yang, Elena V Rodriges Blanko, Qian Peng, Xiaoyan Ma, Joseph R Marszalek, Anirban Maitra, Cassian Yee, Katayoun Rezvani, Elizabeth Shpall, Valerie S LeBleu, Raghu Kalluri
Exosomes are extracellular vesicles produced by all cells with a remarkable ability to efficiently transfer genetic material, including exogenously loaded siRNA, to cancer cells. Here, we report on a bioreactor-based, large-scale production of clinical-grade exosomes employing good manufacturing practice (GMP) standards. A standard operating procedure was established to generate engineered exosomes with the ability to target oncogenic Kras (iExosomes). The clinical-grade GMP iExosomes were tested in multiple in vitro and in vivo studies to confirm suppression of oncogenic Kras and an increase in the survival of several mouse models with pancreatic cancer...
April 19, 2018: JCI Insight
https://www.readbyqxmd.com/read/29669529/improving-quality-of-life-through-the-routine-use-of-the-patient-concerns-inventory-for-head-and-neck-cancer-patients-a-cluster-preference-randomized-controlled-trial
#16
Simon N Rogers, Derek Lowe, Cher Lowies, Seow Tien Yeo, Christine Allmark, Dominic Mcavery, Gerald M Humphris, Robert Flavel, Cherith Semple, Steven J Thomas, Anastasios Kanatas
BACKGROUND: The consequences of treatment for Head and Neck cancer (HNC) patients has profound detrimental impacts such as impaired QOL, emotional distress, delayed recovery and frequent use of healthcare. The aim of this trial is to determine if the routine use of the Patients Concerns Inventory (PCI) package in review clinics during the first year following treatment can improve overall quality of life, reduce the social-emotional impact of cancer and reduce levels of distress. Furthermore, we aim to describe the economic costs and benefits of using the PCI...
April 18, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29669479/long-term-use-of-hydraulic-artificial-urethral-sphincters-in-nine-dogs-from-new-zealand-with-urethral-sphincter-mechanism-incompetence
#17
K R S Morgan, H R Milner, A Tikekar, H L Smith, A R Coomer
AIMS: To report on the long-term outcomes of hydraulic artificial urethral sphincter (HAUS) placement for the correction of urethral sphincter mechanism incompetence (USMI) in New Zealand dogs. METHODS: Retrospective data were obtained from cases of dogs which had a HAUS placed after failed medical and/or surgical management of USMI between August 2012 and November 2016. Owner assessment of urinary incontinence was evaluated by an online survey in May 2017 using a visual analogue scale (0 being normal, 100 being severely affected) for the frequency, volume and severity of any straining to urinate, immediately prior to the placement of the HAUS and at the time of the survey...
April 18, 2018: New Zealand Veterinary Journal
https://www.readbyqxmd.com/read/29669460/current-diagnosis-and-treatment-of-polymyositis-and-dermatomyositis
#18
Hirokazu Sasaki, Hitoshi Kohsaka
Idiopathic inflammatory myopathies (IIMs) are heterogeneous disorders that affect the skeletal muscles. Polymyositis, dermatomyositis, and inclusion body myositis are major IIM subsets. Immune-mediated necrotizing myopathy became recognized as a potentially new IIM subset. Since the new classification criteria published by the International Myositis Classification Criteria Project have higher sensitivity and specificity for IIM classification and subclassification than the previous criteria, they should help precise diagnosis...
April 18, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/29667535/clinical-features-and-short-term-outcome-of-presumptive-intracranial-complications-associated-with-otitis-media-interna-a-multi-center-retrospective-study-of-19-cats-2009-2017
#19
Sarah A Moore, R Timothy Bentley, Sheila Carrera-Justiz, Kari D Foss, Ronaldo C da Costa, Laurie B Cook
Objectives The aim of this study was to compile an overview of the clinical features of intracranial complication of otitis media/interna (OMI) in cats managed across five veterinary referral hospitals. Of additional interest were culture results that could inform empirical antibiotic selection, as well as outcome with both medical and surgical management. Methods A retrospective medical record review was conducted at five veterinary referral practices to identify cats with a diagnosis of intracranial complication secondary to OMI between 2009 and 2017...
April 1, 2018: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/29666802/advances-in-radiotherapy-for-esophageal-cancer
#20
REVIEW
Wei Deng, Steven H Lin
Esophageal cancer is a common type of malignancy worldwide and usually requires multidisciplinary care. Radiotherapy plays an important part in management of the disease. During the past few years, researchers have made much progress about radiotherapy for esophageal cancer, which was revealed in every aspect of clinical practice. Neoadjuvant chemoradiotherapy remains the standard treatment for locally advanced esophageal cancer, whereas neoadjuvant chemotherapy appears to show less toxicities and non-inferior prognosis...
February 2018: Annals of Translational Medicine
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