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https://www.readbyqxmd.com/read/28091349/intranasal-oxytocin-increases-facial-expressivity-but-not-ratings-of-trustworthiness-in-patients-with-schizophrenia-and-healthy-controls
#1
J D Woolley, B Chuang, C Fussell, S Scherer, B Biagianti, D Fulford, D H Mathalon, S Vinogradov
BACKGROUND: Blunted facial affect is a common negative symptom of schizophrenia. Additionally, assessing the trustworthiness of faces is a social cognitive ability that is impaired in schizophrenia. Currently available pharmacological agents are ineffective at improving either of these symptoms, despite their clinical significance. The hypothalamic neuropeptide oxytocin has multiple prosocial effects when administered intranasally to healthy individuals and shows promise in decreasing negative symptoms and enhancing social cognition in schizophrenia...
January 16, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28087270/examining-the-reliability-and-validity-of-the-clinical-assessment-interview-for-negative-symptoms-within-the-management-of-schizophrenia-in-clinical-practice-mosaic-multisite-national-study
#2
Jack J Blanchard, Kristen R Bradshaw, Cristina P Garcia, Henry A Nasrallah, Philip D Harvey, Daniel Casey, Csilla T Csoboth, James I Hudson, Laura Julian, Ellen Lentz, Keith H Nuechterlein, Diana O Perkins, Tracey G Skale, Lonnie R Snowden, Rajiv Tandon, Cenk Tek, Dawn Velligan, Sophia Vinogradov, Cedric O'Gorman
The current study sought to expand on prior reports of the validity and reliability of the CAINS (CAINS) by examining its performance across diverse non-academic clinical settings as employed by raters not affiliated with the scale's developers and across a longer test-retest follow-up period. The properties of the CAINS were examined within the Management of Schizophrenia in Clinical Practice (MOSAIC) schizophrenia registry. A total of 501 participants with a schizophrenia spectrum diagnosis who were receiving usual care were recruited across 15 national Patient Assessment Centers and evaluated with the CAINS, other negative symptom measures, and assessments of functioning, quality of life and cognition...
January 11, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28069563/brief-cognitive-behavioural-therapy-for-patients-in-the-community-with-schizophrenia-randomised-controlled-trial-in-beijing-china
#3
Zhi-Hua Guo, Zhan-Jiang Li, Yun Ma, Jing Sun, Jun-Hua Guo, Wen-Xiu Li, Zhi-Qiang Wang, Hui-Li Xu, Roger M K Ng, Douglas Turkington, David Kingdon
BACKGROUND: Brief cognitive-behavioural therapy (CBT) is an emerging treatment for schizophrenia in community settings; however, further trials are needed, especially in non-Western countries. AIMS: To test the effects of brief CBT for Chinese patients with schizophrenia in the community (trial registration: ChiCTR-TRC-13003709). METHOD: A total of 220 patients with schizophrenia from four districts of Beijing were randomly assigned to either brief CBT plus treatment as usual (TAU) or TAU alone...
January 9, 2017: British Journal of Psychiatry: the Journal of Mental Science
https://www.readbyqxmd.com/read/28069027/reliability-of-health-related-quality-of-life-assessments-made-by-older-adults-and-significant-others-for-health-states-of-increasing-cognitive-impairment
#4
Gina Bravo, Modou Sene, Marcel Arcand
BACKGROUND: Older adults are encouraged by many organizations to engage in advance care planning in the event of decisional incapacity. Planning for future health care often involves anticipating health-related quality of life (HRQoL) in states of reduced cognitive functioning. No study has yet examined whether anticipated HRQoL is stable over time. The accuracy with which significant others can predict how an older adult envisions HRQoL in a future state of cognitive impairment is also unknown...
January 7, 2017: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/28052841/preventing-depression-in-adults-with-subthreshold-depression-health-economic-evaluation-alongside-a-pragmatic-randomized-controlled-trial-of-a-web-based-intervention
#5
Claudia Buntrock, Matthias Berking, Filip Smit, Dirk Lehr, Stephanie Nobis, Heleen Riper, Pim Cuijpers, David Ebert
BACKGROUND: Psychological interventions for the prevention of depression might be a cost-effective way to reduce the burden associated with depressive disorders. OBJECTIVE: To evaluate the cost-effectiveness of a Web-based guided self-help intervention to prevent major depressive disorder (MDD) in people with subthreshold depression (sD). METHODS: A pragmatic randomized controlled trial was conducted with follow-up at 12 months. Participants were recruited from the general population via a large statutory health insurance company and an open access website...
January 4, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28051967/introducing-a-novel-applicant-ranking-tool-to-predict-future-resident-performance-a-pilot-study
#6
Sarah N Bowe, Erik K Weitzel, William N Hannah, Brian M Fitzgerald, Gregory P Kraus, Christopher J Nagy, Stephen A Harrison
The purposes of this study are to (1) introduce our novel Applicant Ranking Tool that aligns with the Accreditation Council for Graduate Medical Education competencies and (2) share our preliminary results comparing applicant rank to current performance. After a thorough literature review and multiple roundtable discussions, an Applicant Ranking Tool was created. Feasibility, satisfaction, and critiques were discussed via open feedback session. Inter-rater reliability was assessed using weighted kappa statistic (κ) and Kendall coefficient of concordance (W)...
January 2017: Military Medicine
https://www.readbyqxmd.com/read/28051902/the-clinical-utility-reliability-and-validity-of-the-rivermead-behavioural-memory-test-third-edition-rbmt-3-in-hong-kong-older-adults-with-or-without-cognitive-impairments
#7
K N K Fong, K K L Lee, Z P Y Tsang, J Y H Wan, Y Y Zhang, A F C Lau
This study examined the use of the Hong Kong version of the Rivermead Behavioral Memory Test-Third Edition (RBMT-3) for older adults, and by presenting the optimal cut-off scores for patients with cognitive impairments, and for a group of peers who have functional everyday cognition. Hundred older adults residing in community dwellings were recruited from three non-government organisations and completed the RBMT-3: 29 patients with mild to moderate dementia, 34 persons at risk for MCI, and 37 matched older adults with everyday functional cognition for a healthy control group (NC)...
January 4, 2017: Neuropsychological Rehabilitation
https://www.readbyqxmd.com/read/28030422/factors-influencing-mini-cex-rater-judgments-and-their-practical-implications-a-systematic-literature-review
#8
Victor Lee, Keira Brain, Jenepher Martin
PURPOSE: At present, little is known about how mini-clinical evaluation exercise (mini-CEX) raters translate their observations into judgments and ratings. The authors of this systematic literature review aim both to identify the factors influencing mini-CEX rater judgments in the medical education setting and to translate these findings into practical implications for clinician assessors. METHOD: The authors searched for internal and external factors influencing mini-CEX rater judgments in the medical education setting from 1980 to 2015 using the Ovid MEDLINE, PsycINFO, ERIC, PubMed, and Scopus databases...
December 27, 2016: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/27966045/inter-rater-variability-of-visual-interpretation-and-comparison-with-quantitative-evaluation-of-11-c-pib-pet-amyloid-images-of-the-japanese-alzheimer-s-disease-neuroimaging-initiative-j-adni-multicenter-study
#9
Tomohiko Yamane, Kenji Ishii, Muneyuki Sakata, Yasuhiko Ikari, Tomoyuki Nishio, Kazunari Ishii, Takashi Kato, Kengo Ito, Michio Senda
PURPOSE: The aim of this study was to assess the inter-rater variability of the visual interpretation of (11)C-PiB PET images regarding the positivity/negativity of amyloid deposition that were obtained in a multicenter clinical research project, Japanese Alzheimer's Disease Neuroimaging Initiative (J-ADNI). The results of visual interpretation were also compared with a semi-automatic quantitative analysis using mean cortical standardized uptake value ratio to the cerebellar cortex (mcSUVR)...
December 13, 2016: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27943055/reproducible-segmentation-of-white-matter-hyperintensities-using-a-new-statistical-definition
#10
Soheil Damangir, Eric Westman, Andrew Simmons, Hugo Vrenken, Lars-Olof Wahlund, Gabriela Spulber
OBJECTIVES: We present a method based on a proposed statistical definition of white matter hyperintensities (WMH), which can work with any combination of conventional magnetic resonance (MR) sequences without depending on manually delineated samples. MATERIALS AND METHODS: T1-weighted, T2-weighted, FLAIR, and PD sequences acquired at 1.5 Tesla from 119 subjects from the Kings Health Partners-Dementia Case Register (healthy controls, mild cognitive impairment, Alzheimer's disease) were used...
December 9, 2016: Magma
https://www.readbyqxmd.com/read/27919404/individualized-metacognitive-therapy-for-delusions-a-randomized-controlled-rater-blind-study
#11
Christina Andreou, Charlotte E Wittekind, Martina Fieker, Ulrike Heitz, Ruth Veckenstedt, Francesca Bohn, Steffen Moritz
BACKGROUND: Theory-driven interventions targeting specific factors that contribute to delusions are receiving increased interest. The present study aimed to assess the efficacy of individualized metacognitive therapy (MCT+), a short manualized intervention that addresses delusion-associated cognitive biases. METHODS: 92 patients with current or past delusions were randomized to receive 12 twice-weekly sessions of either MCT+ or a control intervention within a randomized controlled rater-blind design...
November 29, 2016: Journal of Behavior Therapy and Experimental Psychiatry
https://www.readbyqxmd.com/read/27911295/efficacy-and-safety-of-plasma-exchange-with-5-albumin-to-modify-cerebrospinal-fluid-and-plasma-amyloid-%C3%AE-concentrations-and-cognition-outcomes-in%C3%A2-alzheimer-s-disease-patients-a%C3%A2-multicenter-randomized-controlled-clinical-trial
#12
Mercè Boada, Fernando Anaya, Pilar Ortiz, Javier Olazarán, Joshua R Shua-Haim, Thomas O Obisesan, Isabel Hernández, Joan Muñoz, Mar Buendia, Montserrat Alegret, Asunción Lafuente, Lluís Tárraga, Laura Núñez, Mireia Torres, Joan Ramon Grifols, Isidre Ferrer, Oscar L Lopez, Antonio Páez
BACKGROUND: Studies conducted in animal models and humans suggest the presence of a dynamic equilibrium of amyloid-β (Aβ) peptide between cerebrospinal fluid (CSF) and plasma compartments. OBJECTIVE: To determine whether plasma exchange (PE) with albumin replacement was able to modify Aβ concentrations in CSF and plasma as well as to improve cognition in patients with mild-moderate Alzheimer's disease (AD). METHODS: In a multicenter, randomized, patient- and rater-blind, controlled, parallel-group, phase II study, 42 AD patients were assigned (1 : 1) to PE treatment or control (sham) groups...
November 28, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27893859/hippocampal-calcification-on-computed-tomography-in-relation-to-cognitive-decline-in-memory-clinic-patients-a-case-control-study
#13
Remko Kockelkoren, Jill B De Vis, Willem P Th M Mali, Jeroen Hendrikse, Pim A de Jong, Annemieke M Rozemuller, Huiberdina L Koek
BACKGROUND: It was recently shown that calcification of the hippocampus can be detected on computed tomography (CT) images and these calcifications occur in up to 20% of people over 50 years of age. However, little is known about hippocampal calcification and its relation to cognition and cognitive decline. Therefore, the aim of this study was to (1) determine the prevalence of hippocampal calcification on CT in memory clinic patients controls, and (2) to assess its relation with cognitive decline...
2016: PloS One
https://www.readbyqxmd.com/read/27891725/cognitive-task-demands-and-discourse-performance-after-traumatic-brain-injury
#14
Lindsey Byom, Lyn S Turkstra
BACKGROUND: Social communication problems are common in adults with traumatic brain injury (TBI), particularly problems in spoken discourse. Social communication problems are thought to reflect underlying cognitive impairments. AIMS: To measure the contribution of two cognitive processes, executive functioning (EF) and theory of mind (ToM), to the communication of adults with TBI, and to investigate the relationships between discourse performance and potential communication partners' perceptions...
November 27, 2016: International Journal of Language & Communication Disorders
https://www.readbyqxmd.com/read/27885963/coping-with-discrimination-among-hiv-positive-black-men-who-have-sex-with-men
#15
Laura M Bogart, Sannisha K Dale, Jana Christian, Kinjal Patel, Gary K Daffin, Kenneth H Mayer, David W Pantalone
In the USA, HIV-positive Black men who have sex with men show large disparities in disease outcomes compared to other racial/ethnic and risk groups. This study examined the strategies that HIV-positive Black men who have sex with men use to cope with different types of discrimination. A total of 27 HIV-positive Black men who have sex with men participated in semi-structured interviews, which were transcribed verbatim and coded using thematic analysis by multiple raters. Major coping themes included reactive avoidance (using behaviours, cognitions and emotions to escape from discrimination), a common reaction to racism; proactive avoidance (avoiding situations in which discrimination is anticipated), manifested as selective disclosure of HIV-serostatus; external attribution for discrimination (versus self-blame), used more for sexual orientation and HIV discrimination; and social support-seeking, which most often emerged in response to racism...
November 25, 2016: Culture, Health & Sexuality
https://www.readbyqxmd.com/read/27873423/the-power-of-the-pen-how-to-make-physicians-more-friendly-and-patients-more-attractive
#16
Nurith Epstein, Thomas Brendel, Inga Hege, Diana L Ouellette, Ralf Schmidmaier, Jan Kiesewetter
CONTEXT: Studies have shown that patients' subjective perceptions of physicians' competence and friendliness are relevant aspects of a successful treatment, influencing patients' well-being and trust in the physician. Psychological research has repeatedly shown that unconsciously contracting muscles that are usually used to smile can intensify and even elicit positive feelings (known as facial feedback). Empirical evidence also suggests that a smiling person is favourably judged by others with respect to attractiveness and trustworthiness...
December 2016: Medical Education
https://www.readbyqxmd.com/read/27863317/evaluating-promis-%C3%A2-applied-cognition-items-in-a-sample-of-older-adults-at-risk-for-cognitive-decline
#17
Molly Howland, Curtis Tatsuoka, Kathleen A Smyth, Martha Sajatovic
PROMIS(®) Applied Cognition is a short self-assessment of cognitive abilities and concerns that eliminates the need for a trained rater and provides online question banks that can be uniformly used across health care providers. This 12-month prospective study of 281 elderly individuals evaluates self-perceptions of cognitive functioning in relation to objective cognition, or assessment by an external rater, and compares PROMIS® Applied Cognition Abilities and Concerns subsets with commonly used "legacy" instruments...
January 2017: Psychiatry Research
https://www.readbyqxmd.com/read/27847706/reliability-and-validity-of-korean-version-of-apraxia-screen-of-tulia-k-ast
#18
Soo Jin Kim, You-Na Yang, Jong Won Lee, Jin-Youn Lee, Eunhwa Jeong, Bo-Ram Kim, Jongmin Lee
OBJECTIVE: To evaluate the reliability and validity of Korean version of AST (K-AST) as a bedside screening test of apraxia in patients with stroke for early and reliable detection. METHODS: AST was translated into Korean, and the translated version received authorization from the author of AST. The performances of K-AST in 26 patients (21 males, 5 females; mean age 65.42±17.31 years) with stroke (23 ischemic, 3 hemorrhagic) were videotaped. To test the reliability and validity of K-AST, the recorded performances were assessed by two physiatrists and two occupational therapists twice at a 1-week interval...
October 2016: Annals of Rehabilitation Medicine
https://www.readbyqxmd.com/read/27825402/assessing-capacity-to-consent-to-treatment-with-cholinesterase-inhibitors-in-dementia-using-a-specific-and-standardized-version-of-the-macarthur-competence-assessment-tool-maccat-t
#19
Tanja Mueller, Julia Haberstroh, Maren Knebel, Frank Oswald, Roman Kaspar, Christoph J Kemper, Petra Halder-Sinn, Johannes Schroeder, Johannes Pantel
BACKGROUND: The use of assessment tools has been shown to improve the inter-rater reliability of capacity assessments. However, instrument-based capacity assessments of people with dementia face challenges. In dementia research, measuring capacity with instruments like the MacArthur Competence Assessment Tool for Treatment (MacCAT-T) mostly employ hypothetical treatment vignettes that can overwhelm the abstraction capabilities of people with dementia and are thus not always suitable for this target group...
November 9, 2016: International Psychogeriatrics
https://www.readbyqxmd.com/read/27799289/challenges-and-strategies-for-implementing-mental-health-measurement-for-research-in-low-resource-settings
#20
Robert L Tennyson, Christopher G Kemp, Deepa Rao
The gap between need and access to mental health care is widest in low-resource settings. Health systems in these contexts devote few resources to expanding mental health care, and it is missing from the agenda of most global health donors. This is partially explained by the paucity of data regarding the nature and extent of the mental health burden in these settings, so accurate and comparable measurement is essential to advocating for, developing, and implementing appropriate policies and services. Inaccurate estimation of mental illness prevalence, and misunderstandings regarding its etiologies and expressions, are associated with unnecessary costs to health systems and people living with mental illness...
November 2016: International Health
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