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https://www.readbyqxmd.com/read/27911295/efficacy-and-safety-of-plasma-exchange-with-5-albumin-to-modify-cerebrospinal-fluid-and-plasma-amyloid-%C3%AE-concentrations-and-cognition-outcomes-in%C3%A2-alzheimer-s-disease-patients-a%C3%A2-multicenter-randomized-controlled-clinical-trial
#1
Mercè Boada, Fernando Anaya, Pilar Ortiz, Javier Olazarán, Joshua R Shua-Haim, Thomas O Obisesan, Isabel Hernández, Joan Muñoz, Mar Buendia, Montserrat Alegret, Asunción Lafuente, Lluís Tárraga, Laura Núñez, Mireia Torres, Joan Ramon Grifols, Isidre Ferrer, Oscar L Lopez, Antonio Páez
BACKGROUND: Studies conducted in animal models and humans suggest the presence of a dynamic equilibrium of amyloid-β (Aβ) peptide between cerebrospinal fluid (CSF) and plasma compartments. OBJECTIVE: To determine whether plasma exchange (PE) with albumin replacement was able to modify Aβ concentrations in CSF and plasma as well as to improve cognition in patients with mild-moderate Alzheimer's disease (AD). METHODS: In a multicenter, randomized, patient- and rater-blind, controlled, parallel-group, phase II study, 42 AD patients were assigned (1 : 1) to PE treatment or control (sham) groups...
November 28, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27893859/hippocampal-calcification-on-computed-tomography-in-relation-to-cognitive-decline-in-memory-clinic-patients-a-case-control-study
#2
Remko Kockelkoren, Jill B De Vis, Willem P Th M Mali, Jeroen Hendrikse, Pim A de Jong, Annemieke M Rozemuller, Huiberdina L Koek
BACKGROUND: It was recently shown that calcification of the hippocampus can be detected on computed tomography (CT) images and these calcifications occur in up to 20% of people over 50 years of age. However, little is known about hippocampal calcification and its relation to cognition and cognitive decline. Therefore, the aim of this study was to (1) determine the prevalence of hippocampal calcification on CT in memory clinic patients controls, and (2) to assess its relation with cognitive decline...
2016: PloS One
https://www.readbyqxmd.com/read/27891725/cognitive-task-demands-and-discourse-performance-after-traumatic-brain-injury
#3
Lindsey Byom, Lyn S Turkstra
BACKGROUND: Social communication problems are common in adults with traumatic brain injury (TBI), particularly problems in spoken discourse. Social communication problems are thought to reflect underlying cognitive impairments. AIMS: To measure the contribution of two cognitive processes, executive functioning (EF) and theory of mind (ToM), to the communication of adults with TBI, and to investigate the relationships between discourse performance and potential communication partners' perceptions...
November 27, 2016: International Journal of Language & Communication Disorders
https://www.readbyqxmd.com/read/27885963/coping-with-discrimination-among-hiv-positive-black-men-who-have-sex-with-men
#4
Laura M Bogart, Sannisha K Dale, Jana Christian, Kinjal Patel, Gary K Daffin, Kenneth H Mayer, David W Pantalone
In the USA, HIV-positive Black men who have sex with men show large disparities in disease outcomes compared to other racial/ethnic and risk groups. This study examined the strategies that HIV-positive Black men who have sex with men use to cope with different types of discrimination. A total of 27 HIV-positive Black men who have sex with men participated in semi-structured interviews, which were transcribed verbatim and coded using thematic analysis by multiple raters. Major coping themes included reactive avoidance (using behaviours, cognitions and emotions to escape from discrimination), a common reaction to racism; proactive avoidance (avoiding situations in which discrimination is anticipated), manifested as selective disclosure of HIV-serostatus; external attribution for discrimination (versus self-blame), used more for sexual orientation and HIV discrimination; and social support-seeking, which most often emerged in response to racism...
November 25, 2016: Culture, Health & Sexuality
https://www.readbyqxmd.com/read/27873423/the-power-of-the-pen-how-to-make-physicians-more-friendly-and-patients-more-attractive
#5
Nurith Epstein, Thomas Brendel, Inga Hege, Diana L Ouellette, Ralf Schmidmaier, Jan Kiesewetter
CONTEXT: Studies have shown that patients' subjective perceptions of physicians' competence and friendliness are relevant aspects of a successful treatment, influencing patients' well-being and trust in the physician. Psychological research has repeatedly shown that unconsciously contracting muscles that are usually used to smile can intensify and even elicit positive feelings (known as facial feedback). Empirical evidence also suggests that a smiling person is favourably judged by others with respect to attractiveness and trustworthiness...
December 2016: Medical Education
https://www.readbyqxmd.com/read/27863317/evaluating-promis-%C3%A2-applied-cognition-items-in-a-sample-of-older-adults-at-risk-for-cognitive-decline
#6
Molly Howland, Curtis Tatsuoka, Kathleen A Smyth, Martha Sajatovic
PROMIS(®) Applied Cognition is a short self-assessment of cognitive abilities and concerns that eliminates the need for a trained rater and provides online question banks that can be uniformly used across health care providers. This 12-month prospective study of 281 elderly individuals evaluates self-perceptions of cognitive functioning in relation to objective cognition, or assessment by an external rater, and compares PROMIS® Applied Cognition Abilities and Concerns subsets with commonly used "legacy" instruments...
November 1, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/27847706/reliability-and-validity-of-korean-version-of-apraxia-screen-of-tulia-k-ast
#7
Soo Jin Kim, You-Na Yang, Jong Won Lee, Jin-Youn Lee, Eunhwa Jeong, Bo-Ram Kim, Jongmin Lee
OBJECTIVE: To evaluate the reliability and validity of Korean version of AST (K-AST) as a bedside screening test of apraxia in patients with stroke for early and reliable detection. METHODS: AST was translated into Korean, and the translated version received authorization from the author of AST. The performances of K-AST in 26 patients (21 males, 5 females; mean age 65.42±17.31 years) with stroke (23 ischemic, 3 hemorrhagic) were videotaped. To test the reliability and validity of K-AST, the recorded performances were assessed by two physiatrists and two occupational therapists twice at a 1-week interval...
October 2016: Annals of Rehabilitation Medicine
https://www.readbyqxmd.com/read/27825402/assessing-capacity-to-consent-to-treatment-with-cholinesterase-inhibitors-in-dementia-using-a-specific-and-standardized-version-of-the-macarthur-competence-assessment-tool-maccat-t
#8
Tanja Mueller, Julia Haberstroh, Maren Knebel, Frank Oswald, Roman Kaspar, Christoph J Kemper, Petra Halder-Sinn, Johannes Schroeder, Johannes Pantel
BACKGROUND: The use of assessment tools has been shown to improve the inter-rater reliability of capacity assessments. However, instrument-based capacity assessments of people with dementia face challenges. In dementia research, measuring capacity with instruments like the MacArthur Competence Assessment Tool for Treatment (MacCAT-T) mostly employ hypothetical treatment vignettes that can overwhelm the abstraction capabilities of people with dementia and are thus not always suitable for this target group...
November 9, 2016: International Psychogeriatrics
https://www.readbyqxmd.com/read/27799289/challenges-and-strategies-for-implementing-mental-health-measurement-for-research-in-low-resource-settings
#9
Robert L Tennyson, Christopher G Kemp, Deepa Rao
The gap between need and access to mental health care is widest in low-resource settings. Health systems in these contexts devote few resources to expanding mental health care, and it is missing from the agenda of most global health donors. This is partially explained by the paucity of data regarding the nature and extent of the mental health burden in these settings, so accurate and comparable measurement is essential to advocating for, developing, and implementing appropriate policies and services. Inaccurate estimation of mental illness prevalence, and misunderstandings regarding its etiologies and expressions, are associated with unnecessary costs to health systems and people living with mental illness...
November 2016: International Health
https://www.readbyqxmd.com/read/27798645/there-s-more-to-groove-than-bass-in-electronic-dance-music-why-some-people-won-t-dance-to-techno
#10
Brian C Wesolowski, Alex Hofmann
The purpose of this study was to explore the relationship between audio descriptors for groove-based electronic dance music (EDM) and raters' perceived cognitive, affective, and psychomotor responses. From 198 musical excerpts (length: 15 sec.) representing 11 subgenres of EDM, 19 low-level audio feature descriptors were extracted. A principal component analysis of the feature vectors indicated that the musical excerpts could effectively be classified using five complex measures, describing the rhythmical properties of: (a) the high-frequency band, (b) the mid-frequency band, and (c) the low-frequency band, as well as overall fluctuations in (d) dynamics, and (e) timbres...
2016: PloS One
https://www.readbyqxmd.com/read/27788313/efficacy-of-cognitive-behavioral-therapy-for-insomnia-combined-with-antidepressant-pharmacotherapy-in-patients-with-comorbid-depression-and-insomnia-a-randomized-controlled-trial
#11
Rachel Manber, Daniel J Buysse, Jack Edinger, Andrew Krystal, James F Luther, Stephen R Wisniewski, Mickey Trockel, Helena C Kraemer, Michael E Thase
OBJECTIVES: The Treatment of Insomnia and Depression (TRIAD) study evaluated the efficacy of combining depression pharmacotherapy (using MED, an ecologically valid and generalizable antidepressant medication algorithm) with cognitive-behavioral therapy for insomnia (CBT-I) among individuals with comorbid insomnia and major depressive disorder (MDD) to determine if change in insomnia severity mediates antidepressant outcome. METHODS: This 16-week, 3-site, randomized controlled trial (RCT) randomly assigned 150 participants (recruited between March 2009 and August 2013), who met DSM-IV-TR criteria for insomnia and MDD and were not receiving treatment for either, to receive depression pharmacotherapy plus 7 sessions of either CBT-I or a credible control therapy for insomnia (CTRL)...
October 2016: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/27779445/determining-cannabis-use-status-from-a-photograph-an-assessment-of-the-jay-dar-in-neuropsychologists
#12
Rayna B Hirst, Anna M Teague, Louise M Sodos, Robert E Wickham, L Taighlor Whittington, Brent M Mills, Mitch Earleywine
BACKGROUND: Few studies examining the cognitive effects of chronic cannabis use utilize research designs where examiners are blind to user status. Even in those that do, researchers may be able to guess the user status of participants, leaving these studies vulnerable to the expectancy effect confound. OBJECTIVES: The present study examined the ability of neuropsychologists (those who would conduct research on the cognitive effects of cannabis) to differentiate cannabis users and nonusers based on physical appearance from photographs...
October 25, 2016: Substance Use & Misuse
https://www.readbyqxmd.com/read/27771201/validation-of-the-tablet-administered-brief-assessment-of-cognition-bac-app
#13
Alexandra S Atkins, Tina Tseng, Adam Vaughan, Elizabeth W Twamley, Philip Harvey, Thomas Patterson, Meera Narasimhan, Richard S E Keefe
Computerized tests benefit from automated scoring procedures and standardized administration instructions. These methods can reduce the potential for rater error. However, especially in patients with severe mental illnesses, the equivalency of traditional and tablet-based tests cannot be assumed. The Brief Assessment of Cognition in Schizophrenia (BACS) is a pen-and-paper cognitive assessment tool that has been used in hundreds of research studies and clinical trials, and has normative data available for generating age- and gender-corrected standardized scores...
October 19, 2016: Schizophrenia Research
https://www.readbyqxmd.com/read/27765611/manual-segmentation-of-the-fornix-fimbria-and-alveus-on-high-resolution-3t-mri-application-via-fully-automated-mapping-of-the-human-memory-circuit-white-and-grey-matter-in-healthy-and-pathological-aging
#14
Robert S C Amaral, Min Tae M Park, Gabriel A Devenyi, Vivian Lynn, Jon Pipitone, Julie Winterburn, Sofia Chavez, Mark Schira, Nancy J Lobaugh, Aristotle N Voineskos, Jens C Pruessner, M Mallar Chakravarty
Recently, much attention has been focused on the definition and structure of the hippocampus and its subfields, while the projections from the hippocampus have been relatively understudied. Here, we derive a reliable protocol for manual segmentation of hippocampal white matter regions (alveus, fimbria, and fornix) using high-resolution magnetic resonance images that are complementary to our previous definitions of the hippocampal subfields, both of which are freely available at https://github.com/cobralab/atlases...
October 18, 2016: NeuroImage
https://www.readbyqxmd.com/read/27757137/the-thai-version-of-the-addenbrooke-s-cognitive-examination-iii
#15
Thammanard Charernboon, Kankamol Jaisin, Tiraya Lerthattasilp
The objective of our study was to assess the accuracy of the Thai version of the Addenbrooke's Cognitive Examination III (ACE-T). We used the ACE-T to assess 107 participants aged 60 or over, divided into the following groups: early dementia, n=30; mild cognitive impairment (MCI), n=29; and normal controls (NC), n=48. The ACE-T exhibited good internal consistency (0.93) and inter-rater reliability (1.0). The optimal cut-off score for the ACE-T to differentiate MCI from NC was 75/76, giving a sensitivity of 0...
September 2016: Psychiatry Investigation
https://www.readbyqxmd.com/read/27756567/study-design-and-methodology-for-a-multicentre-randomised-controlled-trial-of-transcranial-direct-current-stimulation-as-a-treatment-for-unipolar-and-bipolar-depression
#16
Angelo Alonzo, Scott Aaronson, Marom Bikson, Mustafa Husain, Sarah Lisanby, Donel Martin, Shawn M McClintock, William M McDonald, John O'Reardon, Zeinab Esmailpoor, Colleen Loo
Transcranial Direct Current Stimulation (tDCS) is a new, non-invasive neuromodulation approach for treating depression that has shown promising efficacy. The aim of this trial was to conduct the first international, multicentre randomised controlled trial of tDCS as a treatment for unipolar and bipolar depression. The study recruited 120 participants across 6 sites in the USA and Australia. Participants received active or sham tDCS (2.5mA, 20 sessions of 30min duration over 4weeks), followed by a 4-week open label active treatment phase and a 4-week taper phase...
October 15, 2016: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/27749468/chronic-pain-patients-perceptions-of-their-future-a-verbal-fluency-task
#17
Adina C Rusu, Tamar Pincus
Depression is a common feature of chronic pain, but the content of depressed cognitions in groups with chronic pain may be qualitatively different from other depressed groups. Future thinking has been extensively studied in depressed population, however, to our knowledge this is the first study to investigate future thinking, using a verbal fluency task, in chronic pain. This study investigated the content of cognitions about the future, which are postulated to be a key mechanism in the development of clinical depression, but have not been studies in groups with chronic pain...
October 1, 2016: Pain
https://www.readbyqxmd.com/read/27721186/the-properties-and-utility-of-the-core-measure-of-melancholia
#18
REVIEW
Gordon Parker, Stacey McCraw
BACKGROUND: The CORE measure was designed to assess a central feature of melancholia - signs of psychomotor disturbance (PMD) - and so provide an alternate non-symptom based measure of melancholia or of its probability. This review evaluates development and application studies undertaken over the last 25 years to consider how well it has met its original objectives. METHODS: All studies published using the CORE measure as either the only or an adjunctive measure of melancholia were obtained and are considered in this review...
January 1, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27692808/surgery-clerkship-evaluations-are-insufficient-for-clinical-skills-appraisal-the-value-of-a-medical-student-surgical-objective-structured-clinical-examination
#19
Kathryn L Butler, David A Hirsh, Emil R Petrusa, D Dante Yeh, Dana Stearns, David E Sloane, Jeffrey A Linder, Gaurab Basu, Lisa A Thompson, Marc A de Moya
OBJECTIVE: Optimal methods for medical student assessment in surgery remain elusive. Faculty- and housestaff-written evaluations constitute the chief means of student assessment in medical education. However, numerous studies show that this approach has poor specificity and a high degree of subjectivity. We hypothesized that an objective structured clinical examination (OSCE) in the surgery clerkship would provide additional data on student performance that would confirm or augment other measures of assessment...
September 27, 2016: Journal of Surgical Education
https://www.readbyqxmd.com/read/27682625/the-acceptability-and-feasibility-of-using-the-adult-social-care-outcomes-toolkit-ascot-to-inform-practice-in-care-homes
#20
Ann-Marie Towers, Nick Smith, Sinead Palmer, Elizabeth Welch, Ann Netten
BACKGROUND: The Adult Social Care Outcomes Toolkit (ASCOT) measures social care related quality of life (SCRQoL) and can be used to measure outcomes and demonstrate impact across different social care settings. This exploratory study built on previous work by collecting new inter-rater reliability data on the mixed-methods version of the toolkit and exploring how it might be used to inform practice in four case study homes. METHOD: We worked with two care home providers to agree an in-depth study collecting SCRQoL data in four case-study homes...
September 29, 2016: BMC Health Services Research
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