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https://www.readbyqxmd.com/read/29793190/comparative-hazards-of-acute-myocardial-infarction-among-hospitalized-patients-with-methamphetamine-or-cocaine-use-disorders-a-retrospective-cohort-study
#1
Russell C Callaghan, Montana Halliday, Jodi Gatley, Jenna Sykes, Lawren Taylor, Claire Benny, Stephen J Kish
BACKGROUND: It is assumed that recreational use of methamphetamine can trigger acute myocardial infarction (AMI) events, but estimates of longitudinal hazards of AMI among methamphetamine users are lacking. METHODS: Retrospective cohort study: Competing-risks analysis was used to estimate time-to-AMI patterns in methamphetamine versus matched appendicitis (population-proxy) and matched cocaine (drug-control) groups. Cohorts were propensity-score-matched using demographic and clinical variables...
April 26, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29793177/long-noncoding-rna-gas5-suppresses-triple-negative-breast-cancer-progression-through-inhibition-of-proliferation-and-invasion-by-competitively-binding-mir-196a-5p
#2
Shuqin Li, Jun Zhou, Zhaoxin Wang, Peishun Wang, Xitao Gao, Yan Wang
Triple-negative breast cancer (TNBC) is considered to be the most aggressive and lethal type of breast cancer. Many studies have suggested that the dysfunction of long noncoding RNAs (lncRNAs) is correlated with breast cancer metastasis and progression. Here, we show that levels of the lncRNA, growth arrest-specific transcript 5 (GAS5), are decreased in TNBC tissues, and this down-regulation of GAS5 is associated with an aggressive tumor phenotype in patients, affecting clinical stage, lymph node metastasis and overall survival...
May 21, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29792768/thai-nursing-students-experiences-of-caring-for-patients-at-the-end-of-life-a-phenomenological-study
#3
Yaowarat Matchim, Parinya Raetong
AIM: To describe Thai nursing students' experiences of providing end-of-life care (EoLC). METHODS: Data were collected via in-depth interviews with 21 nursing students and were analysed using Van Manen's method. FINDINGS: Eight themes emerged based on Van Manen's four lived worlds: feeling excited and worried when receiving an assigned case; feeling disappointed with the health-care team's provision of psychosocial support for patients at the end-of-life and their families; being in a time of uncertainty; recognising that EoLC is a time for gaining merit; knowing that a peaceful place and privacy are needed for promoting a peaceful death; knowing that the real-life classroom is around the patient's bedside; feeling lonely and needing help and support; and creating relationships with patients and families as a nurse...
May 2, 2018: International Journal of Palliative Nursing
https://www.readbyqxmd.com/read/29792543/restructuring-saudi-board-in-restorative-dentistry-sbrd-curriculum-using-canmeds-competency
#4
Bahiah Abdulaziz Al Askar, Fahad Saleh Al Sweleh, Ebtesam Ibrahim Al Wasill, Zubair Amin
OBJECTIVE: The purpose of this paper is to describe the process of adopting the Canadian Medical Education Directions for Specialists (CanMEDS) 2015 competency framework in a dental specialty program to reconstruct the Saudi Board in Restorative Dentistry (SBRD) curriculum and disseminate the lessons learned. Method and development process: The process of curriculum development was started with the selection of SBRD curriculum committee and review of CanMEDS framework. The Committee conducted needs assessment among the stakeholders and adopted CanMEDS 2015 competencies through a careful process...
May 24, 2018: Medical Teacher
https://www.readbyqxmd.com/read/29792461/teamwork-in-the-intensive-care-unit
#5
Jennifer N Ervin, Jeremy M Kahn, Taya R Cohen, Laurie R Weingart
Intensive care units (ICUs) provide care to the most severely ill hospitalized patients. Although ICUs increasingly rely on interprofessional teams to provide critical care, little about actual teamwork in this context is well understood. The ICU team is typically comprised of physicians or intensivists, clinical pharmacists, respiratory therapists, dieticians, bedside nurses, clinical psychologists, and clinicians-in-training. ICU teams are distinguished from other health care teams in that they are low in temporal stability, which can impede important team dynamics...
May 2018: American Psychologist
https://www.readbyqxmd.com/read/29791590/lncrna-ccat1-promotes-cell-proliferation-migration-and-invasion-by-down-regulation-of-mir-143-in-ftc-133-thyroid-carcinoma-cell-line
#6
Tianzheng Yang, Hongyan Zhai, Ruihong Yan, Zhenhu Zhou, Lei Gao, Luqing Wang
Thyroid cancer is a common malignant tumor. Long non-coding RNA colon cancer-associated transcript 1 (lncRNA CCAT1) is highly expressed in many cancers; however, the molecular mechanism of CCAT1 in thyroid cancer remains unclear. Hence, this study aimed to investigate the effect of CCAT1 on human thyroid cancer cell line FTC-133. FTC-133 cells were transfected with CCAT1 expressing vector, CCAT1 shRNA, miR-143 mimic, and miR-143 inhibitor, respectively. After different treatments, cell viability, proliferation, migration, invasion, and apoptosis were measured...
2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/29791212/indian-novice-nurses-perceptions-of-their-role-in-caring-for-women-who-have-experienced-intimate-partner-violence
#7
Sailaxmi Gandhi, Vijayalakshmi Poreddi, Reddy Ss Nikhil, Marimuthu Palaniappan, Suresh Bada Math
BACKGROUND: intimate partner violence (IPV) is a significant health problem and a gross violation of the human rights of women. Nurses play an important role in providing support for these women. There is limited research on nurses' understanding and perceptions of their role in caring for women with IPV issues in India. AIM: to assess novice nurses' perceptions of self-efficacy, educational preparedness and their role in this area. METHODS: this was a cross-sectional descriptive survey carried out among a convenience sample of novice nurses (n=83) at a tertiary care centre using self-reported questionnaires...
May 24, 2018: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/29790441/competences-management-for-improving-performance-in-health-organizations
#8
Simone Fanelli, Gianluca Lanza, Antonello Zangrandi
Purpose The purpose of this paper is to describe the design and construction of a privilege mapping system (clinical and organizational competences) of the medical staff of the Niguarda Hospital in Milan, Italy. The second aim is to measure and assess the impact of implementing an evaluation process of clinical competences at the same hospital. Design/methodology/approach The paper retraces the development and implementation of the evaluation of the privilege system, highlighting the subjects involved, the phases and outputs...
May 14, 2018: International Journal of Health Care Quality Assurance
https://www.readbyqxmd.com/read/29790228/evidence-based-dentistry-skill-acquisition-by-second-year-dental-students
#9
T A Marshall, S C McKernan, C L Straub-Morarend, S Guzman-Armstrong, L Marchini, N Q Handoo, M A Cunningham
INTRODUCTION: Identification and assessment of Evidence-based dentistry (EBD) outcomes have been elusive. Our objective was to describe EBD skill acquisition during the second (D2) year of pre-doctoral dental education and student competency at the end of the year. METHODS: The first and fourth (final) curricular-required EBD Exercises (ie, application of the first 4 steps of the 5-Step evidence-based practice process applied to a real or hypothetical situation) completed by D2 students (n = 151) during 2014-2015 and 2015-2016 were evaluated to measure skill acquisition through use of a novel rubric with measures of performance from novice to expert...
May 22, 2018: European Journal of Dental Education: Official Journal of the Association for Dental Education in Europe
https://www.readbyqxmd.com/read/29790179/merkel-cell-carcinoma-clinical-outcome-and-prognostic-factors-in-351-patients
#10
Linde M van Veenendaal, Alexander C J van Akkooi, Cees Verhoef, Dirk Jan Grünhagen, W Martin C Klop, Gerlof D Valk, Margot E T Tesselaar
BACKGROUND: Merkel cell carcinoma (MCC) is a rare and aggressive neuroendocrine carcinoma of the skin. AIM: To describe clinical outcome and prognostic factors of MCC patients in two expert-centers. METHOD: Patients with histologically confirmed MCC in 1990-2014 were included. Data on patient, tumor characteristics and treatment were retrospectively collected. RESULTS: A total of 351 Patients were evaluated, 153 (44%) males, median age 74 years (range 28-94)...
May 22, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29789616/rbfox1-mbnl1-competition-for-ccug-rna-repeats-binding-contributes-to-myotonic-dystrophy-type-1-type-2-differences
#11
Chantal Sellier, Estefanía Cerro-Herreros, Markus Blatter, Fernande Freyermuth, Angeline Gaucherot, Frank Ruffenach, Partha Sarkar, Jack Puymirat, Bjarne Udd, John W Day, Giovanni Meola, Guillaume Bassez, Harutoshi Fujimura, Masanori P Takahashi, Benedikt Schoser, Denis Furling, Ruben Artero, Frédéric H T Allain, Beatriz Llamusi, Nicolas Charlet-Berguerand
Myotonic dystrophy type 1 and type 2 (DM1, DM2) are caused by expansions of CTG and CCTG repeats, respectively. RNAs containing expanded CUG or CCUG repeats interfere with the metabolism of other RNAs through titration of the Muscleblind-like (MBNL) RNA binding proteins. DM2 follows a more favorable clinical course than DM1, suggesting that specific modifiers may modulate DM severity. Here, we report that the rbFOX1 RNA binding protein binds to expanded CCUG RNA repeats, but not to expanded CUG RNA repeats...
May 22, 2018: Nature Communications
https://www.readbyqxmd.com/read/29789017/leveraging-routine-clinical-materials-and-mobile-technology-to-assess-cbt-fidelity-the-innovative-methods-to-assess-psychotherapy-practices-imapp-study
#12
Shannon Wiltsey Stirman, Luana Marques, Torrey A Creed, Cassidy A Gutner, Robert DeRubeis, Paul G Barnett, Eric Kuhn, Michael Suvak, Jason Owen, Dawne Vogt, Booil Jo, Sonja Schoenwald, Clara Johnson, Kera Mallard, Matthew Beristianos, Heidi La Bash
BACKGROUND: Identifying scalable strategies for assessing fidelity is a key challenge in implementation science. However, for psychosocial interventions, the existing, reliable ways to test treatment fidelity quality are often labor intensive, and less burdensome strategies may not reflect actual clinical practice. Cognitive behavioral therapies (CBTs) provide clinicians with a set of effective core elements to help treat a multitude of disorders, which, evidence suggests, need to be delivered with fidelity to maximize potential client impact...
May 22, 2018: Implementation Science: IS
https://www.readbyqxmd.com/read/29788462/clinicopathological-predictors-for-progression-of-chronic-kidney-disease-in-nephrosclerosis-a-biopsy-based-cohort-study
#13
Masayuki Yamanouchi, Junichi Hoshino, Yoshifumi Ubara, Kenmei Takaichi, Keiichi Kinowaki, Takeshi Fujii, Kenichi Ohashi, Koki Mise, Tadashi Toyama, Akinori Hara, Miho Shimizu, Kengo Furuichi, Takashi Wada
Background: Biopsy-based studies on nephrosclerosis are lacking and the clinicopathological predictors for progression of chronic kidney disease (CKD) are not well established. Methods: We retrospectively assessed 401 patients with biopsy-proven nephrosclerosis in Japan. Progression of CKD was defined as new-onset end-stage renal disease, decrease of estimated glomerular filtration rate (eGFR) by  ≥50% or doubling of serum creatinine, and the sub-distribution hazard ratio (SHR) with 95% confidence interval (CI) for CKD progression was determined for various clinical and histological characteristics in competing risks analysis...
May 19, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29788322/outcomes-and-risk-factors-associated-with-tricuspid-valve-repair-in-children-with-hypoplastic-left-heart-syndrome
#14
Bahaaldin Alsoufi, Raina Sinha, Courtney McCracken, Janet Figueroa, Firat Altin, Kirk Kanter
OBJECTIVES: Tricuspid valve (TV) competence is important for successful palliation of hypoplastic left heart syndrome (HLHS). We report our experience with TV repair in HLHS patients with a focus on TV and right ventricular (RV) function and associated clinical outcomes. METHODS: From 2002 to 2012, 219 neonates with HLHS underwent the Norwood operation. Thirty patients who underwent TV repair at various stages comprised our current series cohort. Echocardiographic and clinical data were reviewed to determine the effectiveness of TV repair and outcomes of the patients...
May 19, 2018: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29788275/feasibility-and-effectiveness-of-laparoscopic-transgastric-stapler-assisted-circumferential-esophageal-mucosectomy-and-simultaneous-fundoplication-in-a-pig-model
#15
D C Steinemann, P C Müller, A-C Schwarz, A Zerz, G R Linke, B P Müller-Stich
Laparoscopic transgastric stapler-assisted mucosectomy (SAM) has been described for minimally invasive circumferential en bloc resection of Barrett's esophagus (BE). Conceivably long-term disease control might be achieved by adding antireflux surgery after resection of BE by SAM. The aim of this study was to assess the feasibility of combined SAM and fundoplication in one laparoscopic procedure in six pigs. Furthermore, the competence of the gastroesophageal junction (GEJ) was assessed at baseline, after SAM, and after subsequent laparoscopic fundoplication...
May 21, 2018: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/29787962/long-term-outcomes-of-acute-and-transient-psychotic-disorders-the-missed-opportunity-of-preventive-interventions
#16
Grazia Rutigliano, Sergio Merlino, Amedeo Minichino, Rashmi Patel, Cathy Davies, Dominic Oliver, Andrea De Micheli, Philip McGuire, Paolo Fusar-Poli
BACKGROUND: Acute and transient psychotic disorders (ATPD) are characterized by an acute onset and a remitting course, and overlap with subgroups of the clinical high-risk state for psychosis. The long-term course and outcomes of ATPD are not completely clear. METHODS: Electronic health record-based retrospective cohort study, including all patients who received a first index diagnosis of ATPD (F23, ICD-10) within the South London and Maudsley (SLaM) National Health Service Trust, between 1 st April 2006 and 15th June 2017...
May 19, 2018: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/29787791/pathogen-dependent-modulation-of-milk-neutrophils-competence-plasma-inflammatory-cytokines-and-milk-quality-during-intramammary-infection-of-sahiwal-bos-indicus-cows
#17
Mohanned Naif Alhussien, Ajay Kumar Dang
The aim of the current study was to investigate the responses of milk neutrophils and plasma inflammatory cytokines to various mastitis pathogens and subsequently on milk composition. Milk was collected from healthy (n = 10) and clinical mastitis indigenous Sahiwal cows naturally infected either with gram-positive bacteria mainly S. aureus (n = 10) and Strep. agalactiae (n = 10) or with gram-negative bacteria, E. coli (n = 10). Phagocytic activity of milk neutrophils decreased in all mastitis cows with the lowest values recorded during gram-positive bacterial infections...
May 19, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29787546/selective-non-operative-management-of-pharyngo-esophageal-injuries-secondary-to-penetrating-neck-trauma-a-single-center-review-of-86-cases
#18
Andre S Madsen, George V Oosthuizen, John L Bruce, Wanda Bekker, Grant L Laing, Damian L Clarke
BACKGROUND: This paper describes our experience with penetrating pharyngo-esophageal injuries (PEI) in the light of a selective conservative approach, and has the objective to define criteria for non-operative management (NOM). METHODS: This retrospective single-center review of patients with penetrating neck injury (PNI) treated for confirmed PEI over a 6-year period aimed to test our proposed hypothesis that NOM is safe for hemodynamically stable patients with PEI, who have no competing indications for exploration, have no established sepsis and who have a water-soluble contrast swallow (WS-swallow) either showing no- or a contained extravasation...
May 4, 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29786947/does-general-experience-affect-self-assessment
#19
Parisa Rezaiefar, Kelly Forse, Joseph K Burns, Sharon Johnston, Elizabeth Muggah, Claire Kendall, Douglas Archibald
BACKGROUND: The assessment of clinical competence is critical in medical education. Understanding the effect of general experience on a physician's self-assessment would help design more effective curricula and evaluations of procedural skills in postgraduate training and continuing professional development (CPD). In this observational study, we assessed the effect of general experience on the correlation between confidence and competence amongst experienced clinicians (ECs) and postgraduate trainees (PGTs) when learning an office-based procedure in pessary care...
May 22, 2018: Clinical Teacher
https://www.readbyqxmd.com/read/29786524/veterinary-herd-health-management-experience-among-farmers-and-farm-managers-in-swedish-dairy-production
#20
C Svensson, K Alvåsen, A C Eldh, J Frössling, H Lomander
A preventive herd health approach will most likely reduce incidences of clinical and subclinical disease. Swedish veterinary organizations offer specific veterinary herd health management (HHM) programs, but these services are not used to a large extent. The aim of this study was to investigate dairy farmers' experience of HHM and the conditions for collaboration with veterinarians in HHM. Six focus group discussions were conducted in March 2015 in West Sweden. In total, 33 dairy farmers participated. The recordings were transcribed and coded using thematic analysis, and the transcripts were reviewed to identify potential factors indicating barriers for farmers to engage a veterinarian in HHM...
July 1, 2018: Preventive Veterinary Medicine
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