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Composite tissue transplant

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https://www.readbyqxmd.com/read/29766773/effects-of-a-structured-physical-activity-program-on-habitual-physical-activity-and-body-composition-in-patients-with-chronic-kidney-disease-and-in-kidney-transplant-recipients
#1
Anna Masajtis-Zagajewska, Katarzyna Muras, Michał Nowicki
OBJECTIVES: In this study, we compared the effects of an individualized physical activity program on lifestyle, metabolic profile, body composition, and quality of life in kidney transplant recipients and patients with chronic kidney disease. MATERIALS AND METHODS: Our study included 24 kidney transplant recipients and 15 patients with chronic kidney disease at stage 3/4. Body composition (impedance spectroscopy) and habitual physical activity (accelerometry) assessed at baseline were used to prepare the individualized physical activity program...
May 16, 2018: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/29765440/prevalence-of-bacteria-and-fungi-in-samples-of-cornea-preservation-fluid
#2
Grażyna Broniek, Ewa Langwińska-Wośko, Małgorzata Sybilska, Jerzy Szaflik, Jacek P Szaflik, Marta Wróblewska
Introduction: Recipients of corneal transplants are at risk of healthcare-associated infections, which, apart from other causes of surgical site infections, may also occur as a result of the transfer of infected corneal tissue. In this study we assessed the risk of bacterial and fungal infections based on the results of routine microbiological testing of cornea preservation fluid samples. Material and methods: We examined a total of 725 samples of corneal preservation fluid, obtained during a period of 3 years (2011-2013)...
April 2018: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/29765410/comparison-of-regenerative-tissue-quality-following-matrix-associated-cell-implantation-using-amplified-chondrocytes-compared-to-synovium-derived-stem-cells-in-a-rabbit-model-for-cartilage-lesions
#3
Hagen Schmal, Justyna M Kowal, Moustapha Kassem, Michael Seidenstuecker, Anke Bernstein, Katharina Böttiger, Tanshiyue Xiong, Norbert P Südkamp, Eva J Kubosch
Known problems of the autologous chondrocyte implantation motivate the search for cellular alternatives. The aim of the study was to test the potential of synovium-derived stem cells (SMSC) to regenerate cartilage using a matrix-associated implantation. In an osteochondral defect model of the medial femoral condyle in a rabbit, a collagen membrane was seeded with either culture-expanded allogenic chondrocytes or SMSC and then transplanted into the lesion. A tailored piece synovium served as a control. Rabbit SMSC formed typical cartilage in vitro...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29756133/biology-of-teeth-and-implants-host-factors-pathology-regeneration-and-the-role-of-stem-cells
#4
F-Michael Eggert, Liran Levin
In chronic periodontitis and peri-implantitis, cells of the innate and adaptive immune systems are involved directly in the lesions within the tissues of the patient. Absence of a periodontal ligament around implants does not prevent a biologic process similar to that of periodontitis from affecting osseointegration. Our first focus is on factors in the biology of individuals that are responsible for the susceptibility of such individuals to chronic periodontitis and to peri-implantitis. Genetic factors are of significant importance in susceptibility to these diseases...
2018: Quintessence International
https://www.readbyqxmd.com/read/29746324/extracorporeal-perfusion-in-vascularized-composite-allotransplantation-current-concepts-and-future-prospects
#5
Maximilian Kueckelhaus, Flemming Puscz, Alexander Dermietzel, Mehran Dadras, Sebastian Fischer, Nicco Krezdorn, Bohdan Pomahac, Tobias Hirsch
Severe injuries of the face and limbs remain a major challenge in today's reconstructive surgery. Vascularized composite allotransplantation (VCA) has emerged as a promising approach to restore these defects. Yet, there are major obstacles preventing VCA from broad clinical application. Two key restrictions are (1) the graft's limited possible ischemia time, keeping the potential donor radius extremely small, and (2) the graft's immunogenicity, making extensive lifelong monitoring and immunosuppressive treatment mandatory...
June 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29744467/3d-bioactive-composite-scaffolds-for-bone-tissue-engineering
#6
REVIEW
Gareth Turnbull, Jon Clarke, Frédéric Picard, Philip Riches, Luanluan Jia, Fengxuan Han, Bin Li, Wenmiao Shu
Bone is the second most commonly transplanted tissue worldwide, with over four million operations using bone grafts or bone substitute materials annually to treat bone defects. However, significant limitations affect current treatment options and clinical demand for bone grafts continues to rise due to conditions such as trauma, cancer, infection and arthritis. Developing bioactive three-dimensional (3D) scaffolds to support bone regeneration has therefore become a key area of focus within bone tissue engineering (BTE)...
September 2018: Bioactive Materials
https://www.readbyqxmd.com/read/29714035/myocardial-extracellular-volume-quantified-by-magnetic-resonance-is-increased-in-cirrhosis-and-related-to-poor-outcome
#7
Signe Wiese, Jens Hove, Silje Mo, Rajeshwar P Mookerjee, Claus L Petersen, Marianne K Vester-Andersen, Naja D Mygind, Jens P Goetze, Andreas Kjaer, Flemming Bendtsen, Søren Møller
BACKGROUND & AIMS: The underlying pathogenesis of cirrhotic cardiomyopathy is unclear. Structural myocardial changes including diffuse fibrosis may be involved and can be accurately assessed by cardiac MRI (CMR) with quantification of the extracellular volume (ECV).This is the first application of this technique in patients with cirrhosis. We aimed to investigate the presence of diffuse myocardial fibrosis and to determine the relation to disease severity, cardiac function, and outcome...
April 30, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29709682/low-subcutaneous-adiposity-associates-with-higher-mortality-in-female-patients-with-cirrhosis
#8
Maryam Ebadi, Puneeta Tandon, Carlos Moctezuma-Velazquez, Sunita Ghosh, Vickie E Baracos, Vera C Mazurak, Aldo J Montano-Loza
BACKGROUND & AIMS: Two main body compartments, skeletal muscle and adipose tissue, exhibit independent functions. We aimed to explore the prognostic significance of skeletal muscle, visceral and subcutaneous adipose tissue, according to sex, in patients with cirrhosis assessed for liver transplantation (LT). METHODS: CT images taken at the 3rd. lumbar vertebra from 677 patients were quantified for three body composition indexes (cm2 /m2 ), visceral adipose tissue index (VATI), subcutaneous adipose tissue index (SATI), and skeletal muscle index (SMI)...
April 27, 2018: Journal of Hepatology
https://www.readbyqxmd.com/read/29670623/human-immune-system-mice-for-the-study-of-human-immunodeficiency-virus-type-1-infection-of-the-central-nervous-system
#9
REVIEW
Teresa H Evering, Moriya Tsuji
Immunodeficient mice transplanted with human cell populations or tissues, also known as human immune system (HIS) mice, have emerged as an important and versatile tool for the in vivo study of human immunodeficiency virus-type 1 (HIV-1) pathogenesis, treatment, and persistence in various biological compartments. Recent work in HIS mice has demonstrated their ability to recapitulate critical aspects of human immune responses to HIV-1 infection, and such studies have informed our knowledge of HIV-1 persistence and latency in the context of combination antiretroviral therapy...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29669585/endoplasmic-reticulum-stress-in-perivascular-adipose-tissue-promotes-destabilization-of-atherosclerotic-plaque-by-regulating-gm-csf-paracrine
#10
Ru Ying, Sheng-Wei Li, Jia-Yuan Chen, Hai-Feng Zhang, Ying Yang, Zhen-Jie Gu, Yang-Xin Chen, Jing-Feng Wang
BACKGROUND: Perivascular adipose tissue (PVAT) accelerates plaque progression and increases cardiovascular risk. We tested the hypothesis that PVAT contributed to plaque vulnerability and investigated whether endoplasmic reticulum stress (ER stress) in PVAT played an important role in vulnerable plaque. METHODS: We transplanted thoracic aortic PVAT or subcutaneous adipose tissue as a control, from donor mice to carotid arteries of recipient apolipoprotein E deficient (apoE-/- ) mice after removing carotid artery collar placed for 6 weeks...
April 18, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29661422/graft-protection-against-cold-ischemia-preservation-an-institute-george-lopez-1-and-histidine-tryptophan-ketoglutarate-solution-appraisal
#11
A Panisello-Rosello, C Castro-Benítez, A Lopez, S Balloji, E Folch-Puy, R Adam, J Roselló-Catafau
Cold storage of organs in preservation solutions, such as Institute George Lopez 1 (IGL-1) or histidine-tryptophan-ketoglutarate (HTK), is a mandatory step for organ transplantation. This preservation leads to an ischemic injury that affects the outcome of the organ. This article studies the liver graft eluate after organ recovery using IGL-1 or HTK solutions. We explore the influence of the volume used for washing out the liver and the consequences in the graft preservation when both solutions are used. Livers were washed out with different volumes of HTK and IGL-1 according to manufacturers' instructions and then preserved in both solutions for 24 hours at 4°C...
April 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29657091/injectable-polypeptide-hydrogels-via-methionine-modification-for-neural-stem-cell-delivery
#12
A L Wollenberg, T M O'Shea, J H Kim, A Czechanski, L G Reinholdt, M V Sofroniew, T J Deming
Injectable hydrogels with tunable physiochemical and biological properties are potential tools for improving neural stem/progenitor cell (NSPC) transplantation to treat central nervous system (CNS) injury and disease. Here, we developed injectable diblock copolypeptide hydrogels (DCH) for NSPC transplantation that contain hydrophilic segments of modified l-methionine (Met). Multiple Met-based DCH were fabricated by post-polymerization modification of Met to various functional derivatives, and incorporation of different amino acid comonomers into hydrophilic segments...
April 5, 2018: Biomaterials
https://www.readbyqxmd.com/read/29623937/efficacy-of-chitosan-and-sodium-alginate-scaffolds-for-repair-of-spinal-cord-injury-in-rats
#13
Zi-Ang Yao, Feng-Jia Chen, Hong-Li Cui, Tong Lin, Na Guo, Hai-Ge Wu
Spinal cord injury results in the loss of motor and sensory pathways and spontaneous regeneration of adult mammalian spinal cord neurons is limited. Chitosan and sodium alginate have good biocompatibility, biodegradability, and are suitable to assist the recovery of damaged tissues, such as skin, bone and nerve. Chitosan scaffolds, sodium alginate scaffolds and chitosan-sodium alginate scaffolds were separately transplanted into rats with spinal cord hemisection. Basso-Beattie-Bresnahan locomotor rating scale scores and electrophysiological results showed that chitosan scaffolds promoted recovery of locomotor capacity and nerve transduction of the experimental rats...
March 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/29613762/synthetic-nanofiber-reinforced-amniotic-membrane-via-interfacial-bonding
#14
Huanhuan Liu, Zhengbing Zhou, Hui Lin, Juan Wu, Brian Ginn, Ji Suk Choi, Xuesong Jiang, Liam Chung, Jennifer H Elisseeff, Samuel Yiu, Hai-Quan Mao
Severe damage to the ocular surface can result in limbal stem cell (LSC) deficiency, which contributes to loss of corneal clarity, potential vision loss, chronic pain, photophobia, and keratoplasty failure. Human amniotic membrane (AM) is the most effective substrate for LSC transplantation to treat patients with LSC deficiency. However, the widespread use of the AM in the clinic remains a challenge because of the high cost for preserving freshly prepared AM and the weak mechanical strength of lyophilized AM...
April 19, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29595735/a-new-composite-eyeball-periorbital-transplantation-model-in-humans-an-anatomical-study-in-preparation-for-eyeball-transplantation
#15
Maria Siemionow, Mehmet Bozkurt, Fatih Zor, Yalcin Kulahci, Safak Uygur, Can Ozturk, Risal Djohan, Frank Papay
BACKGROUND: Vascularized composite allotransplantation offers a new hope for restoration of orbital content and perhaps vision. The aim of this study was to introduce a new composite eyeball-periorbital transplantation model in fresh cadavers in preparation for composite eyeball allotransplantation in humans. METHODS: The composite eyeball-periorbital transplantation flap borders included the inferior border, outlined by the infraorbital rim; the medial border, created by the nasal dorsum; the lateral border, created by the lateral orbital rim; and the superior border, created by the superior part of the eyebrow...
April 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29576752/nutrient-and-antinutrient-compositions-and-heavy-metal-uptake-and-accumulation-in-s-nigrum-cultivated-on-different-soil-types
#16
Adijat Funke Ogundola, Callistus Bvenura, Anthony Jide Afolayan
Solanum nigrum cultivated on different soil texture types, sandy clay loam, silty clay loam, clay loam, loam, and control soils, were evaluated for proximate compositions, antinutrients, vitamins, and mineral composition with plant age using standard analytical methods. Accumulation of trace elements using translocation factor was studied to determine their toxic levels in plant tissues. Data were analysed by ANOVA and results expressed as means and standard deviation. Ash content, crude fibre, protein, alkaloid, phytate, and saponin ranged between 11...
2018: TheScientificWorldJournal
https://www.readbyqxmd.com/read/29561493/lacrimal-apparatus-procurement-in-face-transplantation
#17
Asif Hasan, Colin Maciver, Gaoussou Toure, Jean-Paul Meningaud
The aesthetic outcome of a well-planned and executed vascularized composite tissue face allotransplant is unquestionable; however, complete functional restoration is necessary. The authors studied the possibility of restoring tear duct function in face transplant recipients. They also examined the technical specifics and feasibility of incorporating a lacrimal drainage apparatus into facial allografting. The authors performed a standardized face vascularized composite allograft on 4 hemi-faces (2 fresh cadavers)...
March 20, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29556804/differential-degradation-rate-and-underlying-mechanism-of-a-collagen-chitosan-complex-in-subcutis-spinal-cord-and-brain-tissues-of-rat
#18
Feng Fu, Xiang Zhu, Zhe Qin, Jing-Jing Wang, Chao Xu, Li-Na Wang, Yue Tu, Sai Zhang, Rui-Xin Li, Xiao-Hong Li, Ming-Liang Zhao
Degradation rate is an important index for evaluating biomaterials. The authors' aim was to determine whether the degradation rate of biomaterials is different in distinct tissues and to clarify the underlying mechanism of degradation. The collagen-chitosan (CG-CS) composite scaffolds were prepared using freeze-drying technology. The porosity, water absorption and swelling ratio of the scaffolds were tested in vitro. The scaffolds were implanted into the subcutis, spinal cord and brain tissues of SD rats, the rate of degradation was assessed by continuous monitoring of weight loss, the pathological changes of target areas were observed by histological staining, and matrix metalloproteinase 9 (MMP-9) and lysozyme were detected at the rapid stage of degradation of the scaffolds...
March 19, 2018: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/29555463/genipin-cross-linked-type-ii-collagen-chondroitin-sulfate-composite-hydrogel-like-cell-delivery-system-induces-differentiation-of-adipose-derived-stem-cells-and-regenerates-degenerated-nucleus-pulposus
#19
Xiaopeng Zhou, Jingkai Wang, Weijing Fang, Yiqing Tao, Tengfei Zhao, Kaishun Xia, Chengzhen Liang, Jianming Hua, Fangcai Li, Qixin Chen
Nucleus pulposus (NP) degeneration is usually the origin of intervertebral disc degeneration and consequent lower back pain. Although adipose-derived stem cell (ADSC)-based therapy is regarded to be promising for the treatment of degenerated NP, there is a lack of viable cell carriers to transplant ADSCs into the NP while maintaining cell function. In this study, we developed a type II collagen/chondroitin sulfate (CS) composite hydrogel-like ADSC (CCSA) delivery system with genipin as the cross-linking agent...
April 15, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29551009/assessment-of-physical-performance-and-body-composition-in-male-renal-transplant-patients
#20
Andrea Petronio Rossi, Gianluigi Zaza, Marina Zanardo, Francesco Pedelini, Laura Dalla Verde, Chiara Caletti, Alessia D'Introno, Antonio Lupo, Mauro Zamboni
BACKGROUND: Renal transplant (RTX) recipients seem to experience a better quality of life compared to dialysis patients. However, the factors responsible for this positive effect are not completely defined. Conceivably, a change in the physical performance of these patients could play a role. METHODS: To assess this, we measured: (1) waist circumference, fat mass and appendicular fat-free mass (aFFM) by dual-energy X-ray densitometry, (2) physical performance with the Short Physical Performance Battery, and (3) muscle strength with the handgrip test, in 59 male RTX, 11 chronic kidney disease in conservative treatment (CKD) and 10 peritoneal dialysis (PD) patients...
March 17, 2018: Journal of Nephrology
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