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https://www.readbyqxmd.com/read/29452401/understanding-communication-breakdown-in-the-outpatient-referral-process-in-latin-america-a-cross-sectional-study-on-the-use-of-clinical-correspondence-in-public-healthcare-networks-of-six-countries
#1
Ingrid Vargas, Irene Garcia-Subirats, Amparo-Susana Mogollón-Pérez, Marina Ferreira-de-Medeiros-Mendes, Pamela Eguiguren, Angelica-Ivonne Cisneros, María-Cecilia Muruaga, Fernando Bertolotto, María-Luisa Vázquez
An adequate use of referral and reply letters-the main form of communication between primary care (PC) and out-patient secondary care (SC)-helps to avoid medical errors, test duplications and delays in diagnosis. However, it has been little studied to date in Latin America. The aim is to determine the level and characteristics of PC and SC doctors' use of referral and reply letters and to explore influencing factors in public healthcare networks of Argentina, Brazil, Chile, Colombia, Mexico and Uruguay. A cross-sectional study was conducted through a survey of PC and SC doctors working in public healthcare networks (348 doctors per country)...
February 14, 2018: Health Policy and Planning
https://www.readbyqxmd.com/read/29452283/posterolateral-fusion-plf-vs-transforaminal-lumbar-interbody-fusion-tlif-for-spondylolisthesis-a-systematic-review-and-meta-analysis
#2
REVIEW
Jay M Levin, Joseph E Tanenbaum, Michael P Steinmetz, Thomas E Mroz, Samuel C Overley
BACKGROUND CONTEXT: Lumbar fusion is an effective and durable treatment for symptomatic lumbar spondylolisthesis, however the current literature provides insufficient evidence to recommend an optimal surgical fusion strategy. PURPOSE: To compare the clinical outcomes, fusion rates, blood loss, and operative times between open posterolateral lumbar fusion (PLF) alone and open transforaminal lumbar interbody fusion + posterolateral fusion (TLIF) for spondylolisthesis...
February 13, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29451998/predicting-the-integrated-visual-field-with-wide-scan-optical-coherence-tomography-in-glaucoma-patients
#3
Masaaki Yoshida, Shiho Kunimatsu-Sanuki, Kazuko Omodaka, Toru Nakazawa
PURPOSE: This study aimed to calculate a predicted integrated visual field (IVF) based on predicted monocular visual fields (MVFs) derived, with a new method, from wide-scan optical coherence tomography (OCT) data. MATERIALS AND METHODS: Visual field testing used the central (6 × 4) 24 points of the Humphrey Field Analyzer 24-2 program. OCT scans of a corresponding retinal area, centered on the fovea, were divided into a 6 × 4 grid. The thickness of the macular retinal nerve fiber layer (mRNFL), ganglion cell layer + inner plexiform layer (GCIPL), and mRNFL + GCIPL (GCC) was measured in each grid area...
February 16, 2018: Current Eye Research
https://www.readbyqxmd.com/read/29451907/timber-isoscapes-a-case-study-in-a-mountain-area-in-the-italian-alps
#4
Yuri Gori, Ana Stradiotti, Federica Camin
BACKGROUND: Local timber is still one of the main sources of work and income for mountain communities. However, illegal logging is a major cause of deforestation in many countries and has significant impacts on local communities and biodiversity. Techniques for tracing timber would provide a useful tool to protect local timber industries and contribute to the fight against illegal logging. Although considerable progress has been made in food traceability, timber provenance is still a somewhat neglected research area...
2018: PloS One
https://www.readbyqxmd.com/read/29451897/selective-identification-of-somatic-mutations-in-pancreatic-cancer-cells-through-a-combination-of-next-generation-sequencing-of-plasma-dna-using-molecular-barcodes-and-a-bioinformatic-variant-filter
#5
Yoji Kukita, Kazuyoshi Ohkawa, Ryoji Takada, Hiroyuki Uehara, Kazuhiro Katayama, Kikuya Kato
The accuracy of next-generation sequencing (NGS) for detecting tumor-specific mutations in plasma DNA is hindered by errors introduced during PCR/sequencing, base substitutions caused by DNA damage, and pre-existing mutations in normal cells that are present at a low frequency. Here, we performed NGS of genes related to pancreatic cancer (comprising 2.8 kb of genomic DNA) in plasma DNA (average 4.5 ng) using molecular barcodes. The average number of sequenced molecules was 900, and the sequencing depth per molecule was 100 or more...
2018: PloS One
https://www.readbyqxmd.com/read/29451851/validation-of-a-pre-existed-safety-climate-scale-for-turkish-furniture-manufacturing-industry
#6
Kadri Cemil Akyuz, Ibrahim Yıldirim, Celal Gungor
Understanding the safety climate level is essential to implement a proactive safety program. The objective of this study is to explore the possibility of having a safety climate scale for the Turkish furniture manufacturing industry since there has not been any scale available. The questionnaire recruited 783 subjects. A confirmatory factor analysis (CFA) tested a pre-existed safety scale's fit to the industry. The CFA indicated that the structures of the model present a non-satisfactory fit with the data (χ 2 = 2,033...
February 16, 2018: International Journal of Occupational Safety and Ergonomics: JOSE
https://www.readbyqxmd.com/read/29451414/comparing-methods-of-misclassification-correction-for-studies-of-adolescent-alcohol-use
#7
Melvin D Livingston, Brad Cannell, Keith Muller, Kelli A Komro
BACKGROUND: Despite concerns over measurement error, self-report continues to be the most common measure of adolescent alcohol use used by researchers. Objective measures of adolescent alcohol use continue to advance; however, they tend to be cost prohibitive for larger studies. By combining appropriate statistical techniques and validation subsamples, the benefits of objective alcohol measures can be made more accessible to a greater number of researchers. OBJECTIVES: To compare three easily implemented methods to correct for measurement error when objective measures of alcohol use are available for a subsample of participants, regression calibration, multiple imputation for measurement error (MIME), and probabilistic sensitivity analysis (PSA), and provide guidance regarding the use of each method in scenarios likely to occur in practice...
2018: American Journal of Drug and Alcohol Abuse
https://www.readbyqxmd.com/read/29451098/the-association-between-preaxial-polydactyly-and-radial-longitudinal-deficiency-in-syndromic-cases-a-report-on-nine-families
#8
Mohammad M Al-Qattan
Preaxial polydactyly and radial longitudinal deficiency are usually viewed as two different entities. We present nine families with different disorders in which both preaxial polydactyly and radial longitudinal deficiency were seen in the phenotype. This indicates that both entities may be caused by the same developmental error or insult. The pathogenesis is complex and may be related to the interactions of two signalling loops: the first loop (named as the radial longitudinal deficiency loop) contains genes/proteins responsible for the development of the radial ray; and the second loop (named as the preaxial polydactyly loop) contains the Sonic Hedgehog involved in the pathogenesis of preaxial polydactyly...
January 1, 2018: Journal of Hand Surgery, European Volume
https://www.readbyqxmd.com/read/29451093/adjustment-for-time-invariant-and-time-varying-confounders-in-unexplained-residuals-models-for-longitudinal-data-within-a-causal-framework-and-associated-challenges
#9
K F Arnold, Gth Ellison, S C Gadd, J Textor, Pwg Tennant, A Heppenstall, M S Gilthorpe
'Unexplained residuals' models have been used within lifecourse epidemiology to model an exposure measured longitudinally at several time points in relation to a distal outcome. It has been claimed that these models have several advantages, including: the ability to estimate multiple total causal effects in a single model, and additional insight into the effect on the outcome of greater-than-expected increases in the exposure compared to traditional regression methods. We evaluate these properties and prove mathematically how adjustment for confounding variables must be made within this modelling framework...
January 1, 2018: Statistical Methods in Medical Research
https://www.readbyqxmd.com/read/29451087/multiple-imputation-with-sequential-penalized-regression
#10
Faisal M Zahid, Christian Heumann
Missing data is a common issue that can cause problems in estimation and inference in biomedical, epidemiological and social research. Multiple imputation is an increasingly popular approach for handling missing data. In case of a large number of covariates with missing data, existing multiple imputation software packages may not work properly and often produce errors. We propose a multiple imputation algorithm called mispr based on sequential penalized regression models. Each variable with missing values is assumed to have a different distributional form and is imputed with its own imputation model using the ridge penalty...
January 1, 2018: Statistical Methods in Medical Research
https://www.readbyqxmd.com/read/29451086/efficient-robust-doubly-adaptive-regularized-regression-with-applications
#11
Rohana J Karunamuni, Linglong Kong, Wei Tu
We consider the problem of estimation and variable selection for general linear regression models. Regularized regression procedures have been widely used for variable selection, but most existing methods perform poorly in the presence of outliers. We construct a new penalized procedure that simultaneously attains full efficiency and maximum robustness. Furthermore, the proposed procedure satisfies the oracle properties. The new procedure is designed to achieve sparse and robust solutions by imposing adaptive weights on both the decision loss and the penalty function...
January 1, 2018: Statistical Methods in Medical Research
https://www.readbyqxmd.com/read/29451082/the-short-term-placebo-response-in-children-with-attention-deficit-hyperactivity-disorder-adhd
#12
Ayala Cohen, Moran Plonsky-Toder, Emanuel Tirosh
To assess short-term placebo response in 6- to 13-year-old children with ADHD, children who were administered a double-blind placebo-methylphenidate trial, 1 week each, were included in the analysis. Conners' parents and Teacher Rating scales, the Aggregate Neurobehavioral Student Health and Educational Review inventory, and the Matching Familiar Figure Test were employed. A reduction of 30% or more in one or more of the teachers report subscales was observed in 18.8% of the participants. Attention test performance resulted in 58% of children exhibiting reduction in error rates and 36...
January 1, 2018: Journal of Child Neurology
https://www.readbyqxmd.com/read/29451021/the-uva-padova-type-1-diabetes-simulator-goes-from-single-meal-to-single-day
#13
Roberto Visentin, Enrique Campos-Náñez, Michele Schiavon, Dayu Lv, Martina Vettoretti, Marc Breton, Boris P Kovatchev, Chiara Dalla Man, Claudio Cobelli
BACKGROUND: A new version of the UVA/Padova Type 1 Diabetes (T1D) Simulator is presented which provides a more realistic testing scenario. The upgrades to the previous simulator, which was accepted by the Food and Drug Administration in 2013, are described. METHOD: Intraday variability of insulin sensitivity (S I ) has been modeled, based on clinical T1D data, accounting for both intra- and intersubject variability of daily S I . Thus, time-varying distributions of both subject's basal insulin infusion and insulin-to-carbohydrate ratio were calculated and made available to the user...
February 1, 2018: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/29451016/evaluation-of-a-new-noninvasive-glucose-monitoring-device-by-means-of-standardized-meal-experiments
#14
Andreas Pfützner, Stephanie Strobl, Filiz Demircik, Lisa Redert, Johannes Pfützner, Anke H Pfützner, Alexander Lier
BACKGROUND: Frequent blood glucose readings are the most cumbersome aspect of diabetes treatment for many patients. The noninvasive TensorTip Combo Glucometer (CoG) component employs dedicated mathematical algorithms to analyze the collected signal and to predict tissue glucose at the fingertip. This study presents the performance of the CoG (the invasive and the noninvasive components) during a standardized meal experiment. METHODS: Each of the 36 participants (18 females and males each, age: 49 ± 18 years, 14 healthy subjects, 6 type 1 and 16 type 2 patients) received a device for conducting calibration at home...
February 1, 2018: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/29451014/the-music-method-a-fast-and-quasi-optimal-solution-to-the-muscle-forces-estimation-problem
#15
A Muller, C Pontonnier, G Dumont
The present paper aims at presenting a fast and quasi-optimal method of muscle forces estimation: the MusIC method. It consists in interpolating a first estimation in a database generated offline thanks to a classical optimization problem, and then correcting it to respect the motion dynamics. Three different cost functions - two polynomial criteria and a min/max criterion - were tested on a planar musculoskeletal model. The MusIC method provides a computation frequency approximately 10 times higher compared to a classical optimization problem with a relative mean error of 4% on cost function evaluation...
February 16, 2018: Computer Methods in Biomechanics and Biomedical Engineering
https://www.readbyqxmd.com/read/29450992/assessment-of-fragmentation-strategies-for-large-proteins-using-the-multilayer-molecules-in-molecules-approach
#16
Bishnu Thapa, Daniel Beckett, K V Jovan Jose, Krishnan Raghavachari
We present a rigorous evaluation of the potential for the multilayer Molecules-in-Molecules (MIM) fragmentation method to be applied to large biomolecules. Density functional total energies of a test set of 8 peptides, sizes ranging from 107 to 721 atoms, were evaluated with MIM and compared to unfragmented energies to help develop a protocol for the treatment of large proteins. Fragmentation schemes involving subsystems of 4 to 5 covalently bonded fragments (tetramer or pentamer schemes) were tested with a single level of theory (MIM1) and produced errors on the order of 100 kcal/mol due to the relatively small size of the subsystems and the neglect of nonbonded interactions...
February 16, 2018: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/29450980/prediction-of-enteric-methane-production-yield-and-intensity-in-dairy-cattle-using-an-intercontinental-database
#17
Mutian Niu, Ermias Kebreab, Alexander N Hristov, Joonpyo Oh, Claudia Arndt, André Bannink, Ali R Bayat, André F Brito, Tommy Boland, David Casper, Les A Crompton, Jan Dijkstra, Maguy A Eugène, Phil C Garnsworthy, Md Najmul Haque, Anne L F Hellwing, Pekka Huhtanen, Michael Kreuzer, Bjoern Kuhla, Peter Lund, Jørgen Madsen, Cécile Martin, Shelby C McClelland, Mark McGee, Peter J Moate, Stefan Muetzel, Camila Muñoz, Padraig O'Kiely, Nico Peiren, Christopher K Reynolds, Angela Schwarm, Kevin J Shingfield, Tonje M Storlien, Martin R Weisbjerg, David R Yáñez-Ruiz, Zhongtang Yu
Enteric methane (CH 4 ) production from cattle contributes to global greenhouse gas emissions. Measurement of enteric CH 4 is complex, expensive and impractical at large scales; therefore, models are commonly used to predict CH 4 production. However, building robust prediction models requires extensive data from animals under different management systems worldwide. The objectives of this study were to (1) collate a global database of enteric CH 4 production from individual lactating dairy cattle; (2) determine the availability of key variables for predicting enteric CH 4 production (g/d per cow), yield [g/kg dry matter intake (DMI)], and intensity (g/kg energy corrected milk) and their respective relationships; (3) develop intercontinental and regional models and cross-validate their performance; and (4) assess the trade-off between availability of on-farm inputs and CH 4 prediction accuracy...
February 16, 2018: Global Change Biology
https://www.readbyqxmd.com/read/29450936/correcting-for-missing-and-irregular-data-in-home-range-estimation
#18
C H Fleming, D Sheldon, W F Fagan, P Leimgruber, T Mueller, D Nandintsetseg, M J Noonan, K A Olson, E Setyawan, A Sianipar, J M Calabrese
Home-range estimation is an important application of animal tracking data that is frequently complicated by autocorrelation, sampling irregularity, and small effective sample sizes. We introduce a novel, optimal weighting method that accounts for temporal sampling bias in autocorrelated tracking data. This method corrects for irregular and missing data, such that oversampled times are downweighted and undersampled times are upweighted to minimize error in the home-range estimate. We also introduce computationally efficient algorithms that make this method feasible with large datasets...
February 16, 2018: Ecological Applications: a Publication of the Ecological Society of America
https://www.readbyqxmd.com/read/29450843/detection-of-lung-contour-with-closed-principal-curve-and-machine-learning
#19
Tao Peng, Yihuai Wang, Thomas Canhao Xu, Lianmin Shi, Jianwu Jiang, Shilang Zhu
Radiation therapy plays an essential role in the treatment of cancer. In radiation therapy, the ideal radiation doses are delivered to the observed tumor while not affecting neighboring normal tissues. In three-dimensional computed tomography (3D-CT) scans, the contours of tumors and organs-at-risk (OARs) are often manually delineated by radiologists. The task is complicated and time-consuming, and the manually delineated results will be variable from different radiologists. We propose a semi-supervised contour detection algorithm, which firstly uses a few points of region of interest (ROI) as an approximate initialization...
February 15, 2018: Journal of Digital Imaging: the Official Journal of the Society for Computer Applications in Radiology
https://www.readbyqxmd.com/read/29450592/under-reported-dosimetry-errors-due-to-interplay-effects-during-vmat-dose-delivery-in-extreme-hypofractionated-stereotactic-radiotherapy
#20
Tobias Gauer, Thilo Sothmann, Oliver Blanck, Cordula Petersen, René Werner
BACKGROUND AND PURPOSE: Radiotherapy of extracranial metastases changed from normofractioned 3D CRT to extreme hypofractionated stereotactic treatment using VMAT beam techniques. Random interaction between tumour motion and dynamically changing beam parameters might result in underdosage of the CTV even for an appropriately dimensioned ITV (interplay effect). This study presents a clinical scenario of extreme hypofractionated stereotactic treatment and analyses the impact of interplay effects on CTV dose coverage...
February 15, 2018: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
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