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https://www.readbyqxmd.com/read/28110351/determining-lead-cadmium-and-mercury-in-cosmetics-using-sweeping-via-dynamic-chelation-by-capillary-electrophoresis
#1
Kuan-Ling Chen, Shiuh-Jen Jiang, Yen-Ling Chen
International limits have been established for metal impurities in cosmetics to prevent overexposure to heavy metal ions. Sweeping via dynamic chelation was developed using capillary electrophoresis to analyze lead (Pb), cadmium (Cd) and mercury (Hg) impurities in cosmetics. The sweeping via dynamic chelation mechanism involves a large volume of metal ions being swept by a small quantity of chelating agents that were electrokinetically injected into the capillary to chelate metal ions and increase the detection sensitivity...
January 21, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28110270/assessment-of-neonatal-pain-during-heel-prick-lancet-vs-needle-a-randomized-controlled-study
#2
Carl Britto, Suman P N Rao
BACKGROUND: Heel prick is a frequent painful procedure in newborns. A lancet or a 26-gauge needle is used for a heel prick in India. OBJECTIVE: To compare the pain caused by heel prick with a lancet or a 26-gauge needle in newborns admitted in the neonatal intensive care unit (NICU) using the preterm infant pain profile (PIPP). METHODS: This randomized controlled trial was conducted over 2 months in a Level III NICU with a sample size of 40 subjects (20 in each group), which was required for the study to have a power of 80% with an alpha error of 0...
January 21, 2017: Journal of Tropical Pediatrics
https://www.readbyqxmd.com/read/28110244/quantification-of-postural-control-deficits-in-patients-with-recent-concussion-an-inertial-sensor-based-approach
#3
Cailbhe Doherty, Liang Zhao, John Ryan, Yusuke Komaba, Akihiro Inomata, Brian Caulfield
BACKGROUND: The aim of this study was to quantify postural control ability in a group with concussion compared with a healthy control group. METHOD: Fifteen concussion patients (4 females, 11 males) and a group of fifteen age- and sex-matched controls were recruited. Participants were tested during the performance of the three stance variants (bilateral, tandem and unilateral) of the balance error scoring system standing on a force place, while wearing an inertial measurement unit placed at the posterior aspect of the sacrum...
January 16, 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/28110243/a-biomechanical-testing-system-to-determine-micromotion-between-hip-implant-and-femur-accounting-for-deformation-of-the-hip-implant-assessment-of-the-influence-of-rigid-body-assumptions-on-micromotions-measurements
#4
Steven Leuridan, Quentin Goossens, Jorg Roosen, Leonard Pastrav, Kathleen Denis, Michiel Mulier, Wim Desmet, Jos Vander Sloten
BACKGROUND: Accurate pre-clinical evaluation of the initial stability of new cementless hip stems using in vitro micromotion measurements is an important step in the design process to assess the new stem's potential. Several measuring systems, linear variable displacement transducer-based and other, require assuming bone or implant to be rigid to obtain micromotion values or to calculate derived quantities such as relative implant tilting. METHODS: An alternative linear variable displacement transducer-based measuring system not requiring a rigid body assumption was developed in this study...
January 16, 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/28110223/guilt-without-fault-a-qualitative-study-into-the-ethics-of-forgiveness-after-traumatic-childbirth
#5
Katja Schrøder, Karen la Cour, Jan Stener Jørgensen, Ronald F Lamont, Niels Christian Hvidt
When a life is lost or severely impaired during childbirth, the midwife and obstetrician involved may experience feelings of guilt in the aftermath. Through three empirical cases, the paper examines the sense of guilt in the context of the current patient safety culture in healthcare where a blame-free approach is promoted in the aftermath of adverse events. The purpose is to illustrate how healthcare professionals may experience guilt without being at fault after adverse events, and Gamlund's theory on forgiveness without blame is used as the theoretical framework for this analysis...
January 16, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28110107/controller-design-for-global-fixed-time-synchronization-of-delayed-neural-networks-with-discontinuous-activations
#6
Leimin Wang, Zhigang Zeng, Junhao Hu, Xiaoping Wang
This paper addresses the controller design problem for global fixed-time synchronization of delayed neural networks (DNNs) with discontinuous activations. To solve this problem, adaptive control and state feedback control laws are designed. Then based on the two controllers and two lemmas, the error system is proved to be globally asymptotically stable and even fixed-time stable. Moreover, some sufficient and easy checked conditions are derived to guarantee the global synchronization of drive and response systems in fixed time...
December 23, 2016: Neural Networks: the Official Journal of the International Neural Network Society
https://www.readbyqxmd.com/read/28109918/%C3%AE-ct-based-trabecular-anisotropy-can-be-reproducibly-computed-from-hr-pqct-scans-using-the-triangulated-bone-surface
#7
Hadi S Hosseini, Ghislain Maquer, Philippe K Zysset
The trabecular structure can be assessed at the wrist or tibia via high-resolution peripheral quantitative computed tomography (HR-pQCT). Yet on this modality, the performance of the existing methods, evaluating trabecular anisotropy is usually overlooked, especially in terms of reproducibility. We thus proposed to compare the TRI routine used by SCANCO Medical AG (Brüttisellen, Switzerland), the classical mean intercept length (MIL), and the grey-level structure tensor (GST) to the mean surface length (MSL), a new method for evaluating a second-order fabric tensor based on the triangulation of the bone surface...
January 18, 2017: Bone
https://www.readbyqxmd.com/read/28109841/disruption-of-aromatase-homeostasis-as-the-cause-of-a-multiplicity-of-ailments-a-comprehensive-review
#8
REVIEW
Seema Patel
Human health is beset with a legion of ailments, which is exacerbated by the lifestyle errors. Out of the numerous enzymes in human body, aromatase, a cytochromes P450 enzyme is particularly very critical. Occurring at the crossroads of multiple signalling pathways, its homeostasis is vital. Unfortunately, medications, hormone therapy, chemical additives in food, and endocrine-disrupting personal care products are oscillating the aromatase concentration beyond the permissible level. As this enzyme converts androgens (C19) into estrogens (C18), its agitation has different outcomes in different genders and age groups...
January 18, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28109777/physiological-tremor-8-12hz-component-in-isometric-force-control
#9
Thomas Novak, Karl M Newell
The experiment investigated the influence of physiological tremor (8-12Hz band) on the variability of isometric force control as a function of force level and hand dominance. Subjects were instructed to match a constant force level target line on a computer screen and minimize error in a uni-manual isometric finger abduction task at 5%, 25%, 45%, 65%, and 85% of their maximal voluntary contraction (MVC). The experimental protocol was performed independently with the left and right hands in separate blocks of performance...
January 18, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28109564/development-of-a-surgical-navigation-system-based-on-3d-slicer-for-intraoperative-implant-placement-surgery
#10
Xiaojun Chen, Lu Xu, Huixiang Wang, Fang Wang, Qiugen Wang, Ron Kikinis
Implant placement has been widely used in various kinds of surgery. However, accurate intraoperative drilling performance is essential to avoid injury to adjacent structures. Although some commercially-available surgical navigation systems have been approved for clinical applications, these systems are expensive and the source code is not available to researchers. 3D Slicer is a free, open source software platform for the research community of computer-aided surgery. In this study, a loadable module based on Slicer has been developed and validated to support surgical navigation...
January 18, 2017: Medical Engineering & Physics
https://www.readbyqxmd.com/read/28109534/categorization-based-stranger-avoidance-does-not-explain-the-uncanny-valley-effect
#11
Karl F MacDorman, Debaleena Chattopadhyay
The uncanny valley hypothesis predicts that an entity appearing almost human risks eliciting cold, eerie feelings in viewers. Categorization-based stranger avoidance theory identifies the cause of this feeling as categorizing the entity into a novel category. This explanation is doubtful because stranger is not a novel category in adults; infants do not avoid strangers while the category stranger remains novel; infants old enough to fear strangers prefer photographs of strangers to those more closely resembling a familiar person; and the uncanny valley's characteristic eeriness is seldom felt when meeting strangers...
January 18, 2017: Cognition
https://www.readbyqxmd.com/read/28109469/associations-between-neighbourhood-support-and-financial-burden-with-unmet-needs-of-head-and-neck-cancer-survivors
#12
Katie M O'Brien, Aileen Timmons, Phyllis Butow, Rachael Gooberman-Hill, Eleanor O'Sullivan, Myles Balfe, Linda Sharp
PURPOSE: To assess the unmet needs of head and neck cancer survivors and investigate associated factors. In particular, to explore whether social support (family/friends and neighbours) and financial burden are associated with unmet needs of head and neck cancer (HNC) survivors. METHODS: This was a cross-sectional study of HNC survivors, with 583 respondents included in the analysis. Information was collected on unmet supportive care needs as measured by the Supportive Care Needs Survey (SCNS-SF34)...
February 2017: Oral Oncology
https://www.readbyqxmd.com/read/28109326/from-the-evolution-of-protein-sequences-able-to-resist-self-assembly-to-the-prediction-of-aggregation-propensity
#13
F Bemporad, M Ramazzotti
Folding of polypeptide chains into biologically active entities is an astonishingly complex process, determined by the nature and the sequence of residues emerging from ribosomes. While it has been long believed that evolution has pressed genomes so that specific sequences could adopt unique, functional three-dimensional folds, it is now clear that complex protein machineries act as quality control system and supervise folding. Notwithstanding that, events such as erroneous folding, partial folding, or misfolding are frequent during the life of a cell or a whole organism, and they can escape controls...
2017: International Review of Cell and Molecular Biology
https://www.readbyqxmd.com/read/28109237/atomic-orbital-based-sos-mp2-with-tensor-hypercontraction-ii-local-tensor-hypercontraction
#14
Chenchen Song, Todd J Martínez
In the first paper of the series [Paper I, C. Song and T. J. Martinez, J. Chem. Phys. 144, 174111 (2016)], we showed how tensor-hypercontracted (THC) SOS-MP2 could be accelerated by exploiting sparsity in the atomic orbitals and using graphical processing units (GPUs). This reduced the formal scaling of the SOS-MP2 energy calculation to cubic with respect to system size. The computational bottleneck then becomes the THC metric matrix inversion, which scales cubically with a large prefactor. In this work, the local THC approximation is proposed to reduce the computational cost of inverting the THC metric matrix to linear scaling with respect to molecular size...
January 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28109216/does-the-ionization-potential-condition-employed-in-qtp-functionals-mitigate-the-self-interaction-error
#15
Duminda S Ranasinghe, Johannes T Margraf, Yifan Jin, Rodney J Bartlett
Though contrary to conventional wisdom, the interpretation of all occupied Kohn-Sham eigenvalues as vertical ionization potentials is justified by several formal and numerical arguments. Similarly, the performance of density functional approximations (DFAs) for fractionally charged systems has been extensively studied as a measure of one- and many-electron self-interaction errors (MSIEs). These complementary perspectives (initially recognized in ab initio dft) are shown to lead to the unifying concept that satisfying Bartlett's IP theorem in DFA's mitigates self-interaction errors...
January 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28108981/accuracy-of-sonographically-estimated-fetal-weight-near-delivery-in-pregnancies-complicated-with-diabetes-mellitus
#16
Amy M Valent, Tondra Newman, Sara Kritzer, Kristin Magner, Carri R Warshak
OBJECTIVES: The purpose of this study was to evaluate the accuracy of sonographic estimations of fetal weight (FW) and signed percent error between pregnant patients with and without diabetes mellitus (DM). METHODS: We conducted a retrospective cohort study of all singleton nonanomalous live births who delivered after 34 weeks and received a sonographic estimation of FW within 2 weeks of delivery at the University of Cincinnati Medical Center between 2008 and 2011...
January 21, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28108852/missing-the-target-the-neural-processing-underlying-the-omission-error
#17
Rinaldo Livio Perri, Donatella Spinelli, Francesco Di Russo
The omissions are infrequent errors consisting in missing responses to the target stimuli. This is the first study aimed at investigating the brain activities associated with omissions in a decision-making task. We recorded event-related potentials (ERPs) in 12 subjects which reported a suitable number of omissions in a visual go/no-go task. We investigated both the pre- and post-stimulus brain activities associated with correct and omitted trials. The electrical neuroimaging technique (BESA) was adopted to extract the anterior insula (aIns) activity associated with the prefrontal P2 component (pP2) peaking about 300 ms after the stimulus and reflecting the stimulus-response mapping process...
January 20, 2017: Brain Topography
https://www.readbyqxmd.com/read/28108552/predicted-residual-error-sum-of-squares-of-mixed-models-an-application-to-genomic-prediction
#18
Shizhong Xu
Genomic prediction is a statistical method to predict phenotypes of polygenic traits using high throughput genomic data. Most diseases and behaviors in human and animals are polygenic traits. The majority of agronomic traits in crops are also polygenic. Accurate prediction of these traits can help medical professionals diagnose acute diseases and breeders to increase food products, and therefore, significantly contribute to human health and global food security. The best linear unbiased prediction (BLUP) is an important tool to analyze high throughput genomic data for prediction...
January 20, 2017: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/28108551/genotype-calling-from-population-genomic-sequencing-data
#19
Takahiro Maruki, Michael Lynch
Genotype calling plays important roles in population-genomic studies, which have been greatly accelerated by sequencing technologies. To take full advantage of the resultant information, we have developed maximum-likelihood (ML) methods for calling genotypes from high-throughput sequencing data. As the statistical uncertainties associated with sequencing data depend on depths of coverage, we have developed two types of genotype callers. One approach is appropriate for low-coverage sequencing data, and incorporates population-level information on genotype frequencies and error rates pre-estimated by an ML method...
January 20, 2017: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/28108451/gwar-robust-analysis-and-meta-analysis-of-genome-wide-association-studies
#20
Niki L Dimou, Konstantinos D Tsirigos, Arne Elofsson, Pantelis G Bagos
MOTIVATION: In the context of genome-wide association studies (GWAS), there is a variety of statistical techniques in order to conduct the analysis, but, in most cases, the underlying genetic model is usually unknown. Under these circumstances, the classical Cochran-Armitage trend test is suboptimal. Robust procedures that maximize the power and preserve the nominal type I error rate are preferable. Moreover, performing a meta-analysis using robust procedures is of great interest and has never been addressed in the past...
January 20, 2017: Bioinformatics
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