Giorgia Maroni, Indira Krishnan, Roberta Alfieri, Valerie A Maymi, Nicole Pandell, Eva Csizmadia, Junyan Zhang, Marla Weetall, Art Branstrom, Giulia Braccini, Eva Cabrera San Millán, Barbara Storti, Ranieri Bizzarri, Olivier Kocher, Daniela S Daniela Sanchez Bassères, Robert S Welner, Maria Cristina Magli, Ivan Merelli, John G Clohessy, Azhar Ali, Daniel G Tenen, Elena Levantini
UNLABELLED: Lung cancer is the leading cause of cancer deaths. Lethal pulmonary adenocarcinomas (ADC) present with frequent mutations in the EGFR. Genetically engineered murine models of lung cancer expedited comprehension of the molecular mechanisms driving tumorigenesis and drug response. Here, we systematically analyzed the evolution of tumor heterogeneity in the context of dynamic interactions occurring with the intermingled tumor microenvironment (TME) by high-resolution transcriptomics...
March 26, 2024: Cancer Res Commun