Anthi C Krontira, Cristiana Cruceanu, Leander Dony, Christina Kyrousi, Marie-Helen Link, Nils Rek, Dorothee Pöhlchen, Catarina Raimundo, Signe Penner-Goeke, Alicia Schowe, Darina Czamara, Marius Lahti-Pulkkinen, Sara Sammallahti, Elina Wolford, Kati Heinonen, Simone Roeh, Vincenza Sportelli, Barbara Wölfel, Maik Ködel, Susann Sauer, Monika Rex-Haffner, Katri Räikkönen, Marta Labeur, Silvia Cappello, Elisabeth B Binder
Glucocorticoids are important for proper organ maturation, and their levels are tightly regulated during development. Here, we use human cerebral organoids and mice to study the cell-type-specific effects of glucocorticoids on neurogenesis. We show that glucocorticoids increase a specific type of basal progenitors (co-expressing PAX6 and EOMES) that has been shown to contribute to cortical expansion in gyrified species. This effect is mediated via the transcription factor ZBTB16 and leads to increased production of neurons...
February 27, 2024: Neuron