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https://www.readbyqxmd.com/read/28548954/a-single-nucleotide-polymorphism-of-aire-gene-located-in-the-21q22-3-increases-the-risk-of-rheumatoid-arthritis
#1
Yuan-Sheng Xu, Xi-Jia Jiang, Jian-Min Chen
Several studies addressed the association of autoimmune regulator (AIRE) gene polymorphism with the risk of rheumatoid arthritis (RA); however, their conclusions were inconsistent. For better investigating the effects of this polymorphism on the risk of RA, we conducted this study to evaluate the role of AIRE rs2075786 polymorphism in the risk of RA. Four eligible studies involving 6,755 cases and 7,970 controls were identified by searching the databases of PubMed, CNKI and EMBASE up to February 2017. Our study revealed that AIRE rs2075786 polymorphism was associated with an increased risk of RA under all genetic models...
May 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/28548863/visible-light-promoted-synthesis-of-indoles-by-single-photosensitizer-under-aerobic-conditions
#2
Wen-Qiang Liu, Tao Lei, Zi-Qi Song, Xiu-Long Yang, Cheng-Juan Wu, Xin Jiang, Bin Chen, Chen-Ho Tung, Li-Zhu Wu
The construction of substituted indole skeletons is always an important concern of synthetic chemists because of its prevalent structure found in natural products and biological molecules. Here, we succeeded in preparing indoles and their derivatives from a wide variety of simple enamines via radical cyclization only with catalytic amounts of an iridium(III) photosensitizer (PS) in DMSO solution under air atmosphere. The mechanistic investigation suggests that the reaction involves a radical course to accomplish the conversion of enamines to indoles under visible light irradiation...
May 26, 2017: Organic Letters
https://www.readbyqxmd.com/read/28548846/ambient-size-distributions-and-lung-deposition-of-aerosol-dithiothreitol-measured-oxidative-potential-a-contrast-between-soluble-and-insoluble-particles
#3
Ting Fang, Linghan Zeng, Dong Gao, Vishal Verma, Aleksandr B Stefaniak, Rodney J Weber
Ambient particulate matter (PM) may upset redox homeostasis leading to oxidative stress and adverse health effects. Size distributions of water-insoluble and water-soluble OP^DTT (dithiothreitol assay, measure of oxidative potential per air volume) are reported for a road-side and urban site. The average water-insoluble fractions were 23% and 51%, and 37% and 39% for fine and coarse mode at the road-side and urban site, respectively, measured during different periods. Water-soluble OP^DTT was unimodal peaked near 1-2...
May 26, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28548610/harnessing-youth-and-young-adult-culture-improving-the-reach-and-engagement-of-the-truth%C3%A2-campaign
#4
Elizabeth Hair, Lindsay Pitzer, Morgane Bennett, Michael Halenar, Jessica Rath, Jennifer Cantrell, Nicole Dorrler, Eric Asche, Donna Vallone
The national youth and young adult tobacco prevention mass media campaign, truth®, relaunched in 2014 with the goal of creating "the generation that ends smoking." The objective of this study was to assess whether the strategy of airing truth ads during popular, culturally relevant televised events was associated with higher ad and brand awareness and increases in social media engagement. Awareness of six truth advertisements that aired during popular television events and self-reported social media engagement were assessed via cross-sectional online surveys of youth and young adults aged 15-21 years...
May 26, 2017: Journal of Health Communication
https://www.readbyqxmd.com/read/28548280/air-core-detectors-for-cerenkov-free-scintillation-dosimetry-of-brachytherapy-%C3%AE-sources
#5
Marion Eichmann, Benedikt Thomann
PURPOSE: Plastic scintillation detectors are used for dosimetry in small radiation fields with high dose gradients, green e.g. provided by β-emitting sources like (106) Ru/(106) Rh eye plaques. A drawback is a background signal caused by Cerenkov radiation generated by electrons passing the optical fibers (light guides) of this dosimetry system. Common approaches to correct for the Cerenkov signal are influenced by uncertainties resulting from detector positioning and calibration procedures...
May 26, 2017: Medical Physics
https://www.readbyqxmd.com/read/28547992/spatial-and-temporal-variations-in-characteristic-ratios-of-elemental-carbon-with-carbon-monoxide-and-nitrogen-oxides-across-the-united-states
#6
Aishwarya Raman, Avelino Florentino Arellano
A ratio-based method is used to characterize anthropogenic elemental carbon (ECa) using in-situ measurements and emissions of carbon monoxide (CO) and nitrogen oxides (NOX). We use long-term records of ground-based measurements from United States Environmental Protection Agency Air Quality System (USEPA/AQS) and Interagency Monitoring of Protected Visual Environments to assess the patterns in anthropogenic combustion ratios (ΔECa/ΔCO and ΔECa/ΔNOX) across the US Petroleum Administration for Defense Districts (PADD) regions for the years 2000-2015...
May 26, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28547826/cspbbr3-qd-alox-inorganic-nanocomposites-with-exceptional-stability-in-water-light-and-heat
#7
Anna Loiudice, Seryio Saris, Emad Oveisi, Duncan T L Alexander, Raffaella Buonsanti
Herein, the assembly of CsPbBr3 QD/AlOx inorganic nanocomposite, using atomic layer deposition (ALD) for the growth of the amorphous alumina matrix (AlOx), is proven as a novel protection scheme for this new class of QDs. The nucleation and growth process of AlOx on the QD surface was thoroughly investigated by a miscellanea of techniques which highlighed the importance of the interaction between the ALD precursor and the QD surface to uniformely coat the QDs while preserving the optoelectronic properties. These nanocomposites show an exceptional stability against exposure to air (for at least 45 days), irradiation under simulated solar spectrum (for at least 8h), to thermal treatment (at least up to 200ºC in air), and finally against immersion in water...
May 26, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28547531/neonatal-hyperoxia-perturbs-neuronal-development-in-the-cerebellum
#8
Till Scheuer, Yuliya Sharkovska, Victor Tarabykin, Katharina Marggraf, Vivien Brockmöller, Christoph Bührer, Stefanie Endesfelder, Thomas Schmitz
Impaired postnatal brain development of preterm infants often results in neurological deficits. Besides pathologies of the forebrain, maldeveolopment of the cerebellum is increasingly recognized to contribute to psychomotor impairments of many former preterm infants. However, causes are poorly defined. We used a hyperoxia model to define neonatal damage in cerebellar granule cell precursors (GCPs) and in Purkinje cells (PCs) known to be essential for interaction with GCPs during development. We exposed newborn rats to 24 h 80% O2 from age P6 to P7 to identify postnatal and long-term damage in cerebellar GCPs at age P7 after hyperoxia and also after recovery in room air thereafter until P11 and P30...
May 25, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28547375/the-effects-of-ozone-on-human-health
#9
Daniela Nuvolone, Davide Petri, Fabio Voller
Ozone is a highly reactive, oxidative gas associated with adverse health outcome, including mortality and morbidity. Data from monitoring sites worldwide show levels of ozone often exceeding EU legislation threshold and the more restrictive WHO guidelines for the protection of human health. Well-established evidence has been produced for short-term effects, especially on respiratory and cardiovascular systems, associated to ozone exposure. Less conclusive is the evidence for long-term effects, reporting suggestive associations with respiratory mortality, new-onset asthma in children and increased respiratory symptom effects in asthmatics...
May 25, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28547369/air-protection-programmes-in-poland-in-the-context-of-the-low-emission
#10
Janusz Adamczyk, Arkadiusz Piwowar, Maciej Dzikuć
The protection of the air against pollutants from individual boiler plants is a big challenge in Poland. It results mainly from the preference for coal, the national energy carrier, the use of old low-efficiency boilers and the location of Poland in a temperate climate where the heating period lasts at least 5 months. This article presents a wide range of activities aimed at the reduction of the environmental impact of the emissions of pollutants from individual heat sources-the so-called low emission. The article presents the extent of the national legislation resulting from the European Union regulations...
May 25, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28547129/quantitative-analysis-of-dynamic-18-f-fdg-pet-ct-for-measurement-of-lung-inflammation
#11
Christopher Coello, Marie Fisk, Divya Mohan, Frederick J Wilson, Andrew P Brown, Michael I Polkey, Ian Wilkinson, Ruth Tal-Singer, Philip S Murphy, Joseph Cheriyan, Roger N Gunn
BACKGROUND: An inflammatory reaction in the airways and lung parenchyma, comprised mainly of neutrophils and alveolar macrophages, is present in some patients with chronic obstructive pulmonary disease (COPD). Thoracic fluorodeoxyglucose ((18)F-FDG) positron emission tomography (PET) has been proposed as a promising imaging biomarker to assess this inflammation. We sought to introduce a fully quantitative analysis method and compare this with previously published studies based on the Patlak approach using a dataset comprising (18)F-FDG PET scans from COPD subjects with elevated circulating inflammatory markers (fibrinogen) and matched healthy volunteers (HV)...
December 2017: EJNMMI Research
https://www.readbyqxmd.com/read/28546506/age-dependent-effects-of-water-striders-moving-on-perturbed-water-surfaces
#12
Victor Manuel Ortega-Jimenez, Lisa von Rabenau, Robert Dudley
Surface roughness is a ubiquitous phenomenon in both oceanic and terrestrial waters. For insects that live at the air-water interface, such as water striders, non-linear and multi-scale perturbations produce dynamic surface deformations which may impair locomotion. We studied escape jumps of adults, juveniles, and first-instar larvae of the water strider Aquarius remigis on smooth, wave-dominated, and bubble-dominated water surfaces. Effects of substrate on takeoff jumps were substantial, with significant reductions in take-off angles, peak translational speeds, attained heights, and power expenditure on more perturbed water surfaces...
May 25, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28546266/health-related-quality-of-life-and-risk-factors-associated-with-spirometric-restriction
#13
Stefano Guerra, Anne-Elie Carsin, Dirk Keidel, Jordi Sunyer, Bénédicte Leynaert, Christer Janson, Debbie Jarvis, Daiana Stolz, Thomas Rothe, Marco Pons, Alexander Turk, Josep M Anto, Nicole Probst-Hensch
The restrictive spirometric pattern is associated with a substantial morbidity and mortality burden. We sought to determine to what extent spirometric restriction is associated with impaired quality of life.We used data from two large population-based European cohorts: 6698 European Community Respiratory Health Survey (ECRHS) and 6069 Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults (SAPALDIA) adult participants. The restrictive pattern was defined as forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) ≥lower limit of normal (LLN) and FVC <LLN; an obstructive pattern was defined as FEV1/FVC <LLN independent of FVC...
May 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28546109/background-activity-and-visual-responsiveness-of-caudate-nucleus-neurons-in-halothane-anaesthetised-and-in-awake-behaving-cats
#14
Balázs Barkóczi, Tamás Nagypál, Diána Nyujtó, Xénia Katona, Gabriella Eördegh, Balázs Bodosi, György Benedek, Gábor Braunitzer, Attila Nagy
This study focuses on the important question whether brain activity recorded from anaesthetised, paralyzed animals is comparable to that recorded from awake, behaving ones. We compared neuronal activity recorded from the caudate nucleus (CN) of two halothane-anaesthetised, paralyzed and two awake, behaving cats. In both models, extracellular recordings were made from the CN during static and dynamic visual stimulation. The anaesthesia was maintained during the recordings by a gaseous mixture of air and halothane (1...
May 22, 2017: Neuroscience
https://www.readbyqxmd.com/read/28546050/shared-decision-making-in-argentina-in-2017
#15
Mariela Barani, Karin Kopitowski, Carolina Carrara, María Victoria Ruiz Yanzi
Argentina is a high-middle income country located in Southern South America with an estimated population of 44 million inhabitants. The epidemiological profile of the population is characterised by an increase of non-communicable diseases. The health system is heterogeneous, fragmented and loosely integrated. There are no unified research agenda or government initiatives encouraging the implementation of and research on Shared Decision-Making (SDM). Progress has been made lately to respect patient autonomy through the enactment of the 'Patients' Rights Act', which expressly enshrines the right of patients to get information as a key element of decision-making...
May 22, 2017: Zeitschrift Für Evidenz, Fortbildung und Qualität Im Gesundheitswesen
https://www.readbyqxmd.com/read/28546005/fast-epithermal-and-thermal-photoneutron-dosimetry-in-air-and-in-tissue-equivalent-phantom-for-a-high-energy-x-ray-medical-accelerator
#16
Mehdi Sohrabi, Amir Hakimi
Photoneutron (PN) dosimetry in fast, epithermal and thermal energy ranges originated from the beam and albedo neutrons in high-energy X-ray medical accelerators is highly important from scientific, technical, radiation protection and medical physics points of view. Detailed dose equivalents in the fast, epithermal and thermal PN energy ranges in air up to 2m as well as at 35 positions from the central axis of 12 cross sections of the phantom at different depths were determined in 18MV X-ray beams of a Siemens ONCOR accelerator...
May 22, 2017: Zeitschrift Für Medizinische Physik
https://www.readbyqxmd.com/read/28546003/thymic-epithelial-cell-specific-deletion-of-jmjd6-reduces-aire-protein-expression-and-exacerbates-disease-development-in-a-mouse-model-of-autoimmune-diabetes
#17
Toyoshi Yanagihara, Takahiro Tomino, Takehito Uruno, Yoshinori Fukui
Thymic epithelial cells (TECs) establish spatially distinct microenvironments in which developing T cells are selected to mature or die. A unique property of medullary TECs is their expression of thousands of tissue-restricted self-antigens that is largely under the control of the transcriptional regulator Aire. We previously showed that Jmjd6, a lysyl hydroxylase for splicing regulatory proteins, is important for Aire protein expression and that transplantation of Jmjd6-deficient thymic stroma into athymic nude mice resulted in multiorgan autoimmunity...
May 22, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28545948/numerical-investigation-of-mist-air-impingement-cooling-on-ribbed-blade-leading-edge-surface
#18
Qingfei Bian, Jin Wang, Yi-Tung Chen, Qiuwang Wang, Min Zeng
The working gas turbine blades are exposed to the environment of high temperature, especially in the leading-edge region. The mist/air two-phase impingement cooling has been adopted to enhance the heat transfer on blade surfaces and investigate the leading-edge cooling effectiveness. An Euler-Lagrange particle tracking method is used to simulate the two-phase impingement cooling on the blade leading-edge. The mesh dependency test has been carried out and the numerical method is validated based on the available experimental data of mist/air cooling with jet impingement on a concave surface...
May 23, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28545939/relationship-between-climatic-factors-and-air-quality-with-tuberculosis-in-the-federal-district-brazil-2003-2012
#19
Fernanda Monteiro de Castro Fernandes, Eder de Souza Martins, Daniella Melo Arnaud Sampaio Pedrosa, Maria do Socorro Nantua Evangelista
INTRODUCTION: Despite the high rate of tuberculosis (TB) indicators in Brazil, the Federal District (FD) shows a low prevalence of the disease. OBJECTIVE: To analyze the relationship between climatic factors and air quality with tuberculosis in the Brazilian Federal District. METHODOLOGY: This was an ecological and descriptive study comparing 3927 new cases of TB registered at the Federal District Tuberculosis Control Program with data from the National Institute of Meteorology, Brazilian Institute of Geography and Statistics, Brazilian Agricultural Research Institute, Brasilia Environmental Institute, and the Federal District Planning Company...
May 22, 2017: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28545896/morphological-identification-and-dna-barcoding-of-a-new-species-of-parabrachiella-siphonostomatoida-lernaeopodidae-with-aspects-of-their-intraspecific-variation
#20
M M Montes, R Castro-Romero, S R Martorelli
We present a detailed morphological description and a DNA barcoding of Parabrachiella platensis n. sp. collected from Mugil liza Valenciennes in Samborombon Bay (Buenos Aires, Argentina). This new species was compared with two Parabrachiella species parasitic on mugilids: Parabrachiella exilis (Shiino, 1956) and Parabrachiella mugilis (Kabata, Raibaut et Ben Hassine, 1971). Parabrachiella platensis n. sp. differs from those species in the shape of posterior processes, the anal slit with two pairs of bipartite papillae, the size of cephalothorax, the trunk, the maxilla, the microhabitat on the host, and the lack of caudal rami...
May 22, 2017: Acta Tropica
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