Pradip K Kamat, Mohammad Badruzzaman Khan, Shahneela Siddiqui, Dylan Williams, Evila da Silva Lopes Salles, Sahar Emami Naeini, Ali S Arbab, Daniel R Rudic, Babak Baban, Krishnan M Dhandapani, David C Hess
Ischemic stroke is caused by obstructed cerebral blood flow, which results in neurological injury and poor outcomes. Pro-inflammatory signaling from both residential and infiltrating immune cells potentiates cerebral injury and worsens patient outcomes after stroke. While the occurrence of a stroke exhibits a time-of-day-dependent pattern, it remains unclear whether disrupted circadian rhythms modulate post-stroke immunity. In this study, we hypothesized that stroke timing differentially affects immune activation in mice...
December 13, 2023: Translational Stroke Research