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https://www.readbyqxmd.com/read/29786945/a-comparative-study-of-dietary-habits-and-nutritional-intakes-among-korean-adults-according-to-current-depression-status
#1
Yuri Seo, Youjin Je
INTRODUCTION: Data regarding the association between depression and dietary factors in Korean adults are limited. We hypothesized that Korean men and women with depression would have poorer nutritional intakes and different dietary habits than those without depression. METHODS: This study was based on data from the Korea National Health and Nutrition Examination Survey conducted during 2012 to 2014. Overall, 10 591 subjects (4308 men, 6529 women) aged 19 to 64 years were selected and categorized according to current depression status...
May 21, 2018: Asia-Pacific Psychiatry: Official Journal of the Pacific Rim College of Psychiatrists
https://www.readbyqxmd.com/read/29786902/engineered-metalloenzymes-with-non-canonical-coordination-environments
#2
Takahiro Hayashi, Donald Hilvert, Anthony P Green
Nature employs a limited number of genetically encoded, metal coordinating residues to create metalloenzymes with diverse structures and functions. Engineered components of the cellular translation machinery can now be exploited to genetically encode non-canonical ligands with user-defined electronic and structural properties. This ability to efficiently install 'chemically programmed' ligands into proteins can provide powerful chemical probes of metalloenzyme mechanisms and presents excellent opportunities to create metalloprotein catalysts with augmented properties and novel activities...
May 22, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29786901/degradable-polymers-and-nanoparticles-built-from-salicylic-acid
#3
Saeed Akkad, Christopher J Serpell
As more evidence emerges supporting the possibility that nonsteroidal anti-inflammatory drugs, especially aspirin (acetyl salicylic acid), might have a role in the prevention and management of certain types of cancer, there have been several attempts to fabricate salicylic acid-based polymers that can be employed in the targeted therapy of tumors. The primary disadvantage so far has been in use of nontherapeutic polymeric backbones that constitute the majority of the therapeutic particle's size. The focus of this research is the creation of a biodegradable polymer consisting only of salicylic acid, and its use as the main building block in targeted nanotherapeutics that would consequently provide both high local dose and sustained release of the active moiety...
May 22, 2018: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/29786855/speciation-of-bio-available-iodine-in-abalone-haliotis-discus-hannai-by-high-performance-liquid-chromatography-hyphenated-with-inductively-coupled-plasma-mass-spectrometry-using-an-in-vitro-method
#4
Han Sol Doh, Hyun Jin Park
Abalone is one of the most valuable marine products found in East Asia because it is rich in nutritious substances including iodine. In this study, the in vitro dialyzability approach was used to assess the bio-available iodine species in abalone. Iodide, iodate, 3-iodo-L-tyrosine (MIT), and 3,5-diiodo-L-tyrosine (DIT) were separated by high-performance liquid chromatography hyphenated with inductively coupled plasma-mass spectrometry (HPLC-ICP-MS). To assure the consistency, reliability, and accuracy of the data, the method was validated...
May 22, 2018: Journal of Food Science
https://www.readbyqxmd.com/read/29786845/a-simple-and-portable-screening-method-for-adulterated-olive-oils-using-the-hand-held-ftir-spectrometer-and-chemometrics-tools
#5
Meng Pan, Suqin Sun, Qun Zhou, Jianbo Chen
Extra virgin olive oil has been one of the most common targets for economically motivated food adulteration. This research employed the hand-held FTIR spectrometer to develop the simple and portable screening methods for extra virgin olive oils adulterated with other cheaper vegetable oils. With the help of the ATR probe and chemometrics tools, oil samples can be measured directly without any pretreatment, then the spectra can be interpreted automatically to determine the possibility of adulteration and estimate the content of adulterant oil...
May 22, 2018: Journal of Food Science
https://www.readbyqxmd.com/read/29786812/the-microrna-expression-profile-in-rat-lung-tissue-early-after-burn-injury
#6
Donghai Zhang, Yang Chang, Shaofang Han, Longlong Yang, Quan Hu, Yonghui Yu, Lingying Liu, Jiake Chai
BACKGROUND: Severe burn causes acute lung injury in many victims, but the related mechanisms have been barely investigated. microRNAs (miRNAs) important regulators in numerous physiological and pathophysiological process. However, the roles of miRNAs in burn lung injury are untested. METHODS: Six healthy male Sprague-Dawley rats were randomly assigned into burn and sham groups. Lung injury was evaluated by hematoxylin and eosin (HE) staining at 24 h after injury...
May 2018: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
https://www.readbyqxmd.com/read/29786782/preclinical-impact-of-high-dose-intermittent-antiangiogenic-tyrosine-kinase-inhibitor-pazopanib-in-intrinsically-resistant-tumor-models
#7
Elaine Reguera-Nuñez, Shan Man, Ping Xu, Robert S Kerbel
Antiangiogenic tyrosine kinase inhibitors (TKIs) target vascular endothelial growth factor receptors and other receptor tyrosine kinases. As a result of toxicity, the clinical failures or the modest benefits associated with antiangiogenic TKI therapy may be related in some cases to suboptimal drug dosing and scheduling, thereby facilitating resistance. Most antiangiogenic TKIs, including pazopanib, are administered on a continuous daily basis. Here, instead, we evaluated the impact of increasing the dose and administering the drug intermittently...
May 21, 2018: Angiogenesis
https://www.readbyqxmd.com/read/29786777/the-biomechanics-of-the-inter-lamellar-matrix-and-the-lamellae-during-progression-to-lumbar-disc-herniation-which-is-the-weakest-structure
#8
Javad Tavakoli, Dhara B Amin, Brian J C Freeman, John J Costi
While microstructural observations have improved our understanding of possible pathways of herniation progression, no studies have measured the mechanical failure properties of the inter-lamellar matrix (ILM), nor of the adjacent lamellae during progression to herniation. The aim of this study was to employ multiscale, biomechanical and microstructural techniques to evaluate the effects of progressive induced herniation on the ILM and lamellae in control, pre-herniated and herniated discs (N = 7), using 2 year-old ovine spines...
May 21, 2018: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/29786776/a-framework-for-image-based-modeling-of-acute-myocardial-ischemia-using-intramurally-recorded-extracellular-potentials
#9
Brett M Burton, Kedar K Aras, Wilson W Good, Jess D Tate, Brian Zenger, Rob S MacLeod
The biophysical basis for electrocardiographic evaluation of myocardial ischemia stems from the notion that ischemic tissues develop, with relative uniformity, along the endocardial aspects of the heart. These injured regions of subendocardial tissue give rise to intramural currents that lead to ST segment deflections within electrocardiogram (ECG) recordings. The concept of subendocardial ischemic regions is often used in clinical practice, providing a simple and intuitive description of ischemic injury; however, such a model grossly oversimplifies the presentation of ischemic disease-inadvertently leading to errors in ECG-based diagnoses...
May 21, 2018: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/29786727/rational-design-of-multi-functional-gold-nanoparticles-with-controlled-biomolecule-adsorption-a-multi-method-approach-for-in-depth-characterization
#10
Isaac Ojea-Jiménez, Robin Capomaccio, Inês Osório, Dora Mehn, Giacomo Ceccone, Rohanah Hussain, Giuliano Siligardi, Pascal Colpo, François Rossi, Douglas Gilliland, Luigi Calzolai
Multi-functionalized nanoparticles are of great interest in biotechnology and biomedicine, especially for diagnostic and therapeutic purposes. However, at the moment the characterization of complex, multi-functional nanoparticles is still challenging and this hampers the development of advanced nanomaterials for biological applications. In this work, we have designed a model system consisting of gold nanoparticles functionalized with two differentially-terminated poly(ethylene oxide) ligands, providing both "stealth" properties and protein-binding capabilities to the nanoparticles...
May 22, 2018: Nanoscale
https://www.readbyqxmd.com/read/29786725/a-convergent-strategy-towards-febrifugine-and-related-compounds
#11
T M M Maiden, N Mbelesi, P A Procopiou, S Swanson, J P A Harrity
We report a modular five step synthetic route to the febrifugines that employs 2-(chloromethyl)allyl-trimethylsilane as a conjunctive reagent for the coupling of the piperidine and quinazolinone groups. We also demonstrate the application of a recent Rh-catalyzed quinazolinone synthesis for the facile generation of febrifugine analogs.
May 22, 2018: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/29786716/unexpected-protonation-state-of-glu197-discovered-from-simulations-of-tacrine-in-butyrylcholinesterase
#12
Xiao Wan, Yuan Yao, Lei Fang, Junjun Liu
Butyrylcholinesterase (BChE) has been actively involved in drug discoveries from many fields for decades. In the crystal structure of the BChE-tacrine complex, there is an unanticipated formyl-proline molecule resolved very close to tacrine, raising an essential question on how reliable it is to apply the binding pose in a crystal structure to analyze related experimental observations, in which no formyl-proline is actually involved. In this study, by performing a series of 100 ns molecular dynamics simulations, we demonstrate that it is safe to employ the structural information from this crystal structure to analyze related experimental observations...
May 22, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29786680/-the-comprehensive-evaluation-of-the-bioclimatic-comfort-at-the-territories-of-the-russian-far-east-with-reference-to-winter-time-recreational-activities-and-primary-wellness-tourism
#13
N M Pestereva, A F Khechumyan, N Vorozbit
BACKGROUND: in the framework of the current tendency toward the further development of the socio-economic sphere in the Russian Far East (RFE), the relevant investigations aimed at creating the comfortable conditions for recreational and touristic activities as well as for rehabilitative therapy of the local population acquire the increasingly greater importance. AIM: The objective of the present study was the comprehensive evaluation of the bioclimatic comfort at the territories of interest with special reference to winter-time recreational activities and primary wellness tourism...
May 21, 2018: Voprosy Kurortologii, Fizioterapii, i Lechebnoĭ Fizicheskoĭ Kultury
https://www.readbyqxmd.com/read/29786673/fabrication-flexible-and-luminescent-nanofibrillated-cellulose-films-with-modified-sral%C3%A2-o%C3%A2-eu-dy-phosphors-via-nanoscale-silica-and-aminosilane
#14
Longfei Zhang, Shaoyi Lyu, Zhilin Chen, Siqun Wang
Flexible 2,2,6,6-tetramethylpiperidine-1-oxyl radical (TEMPO)-oxidized nanofibrillated cellulose (ONFC) films with long afterglow luminescence containing modified SrAl₂O₄: Eu2+ , Dy3+ (SAOED) phosphors were fabricated by a template method. Tetraethyl orthosilicate (TEOS) and (3-aminopropyl) trimethoxy-silane (APTMS) were employed cooperatively to improve the water resistance and compatibility of the SAOED particles in the ONFC suspension. The structure and morphology after modification evidenced the formation of a superior SiO₂ layer and coarse amino-compounds on the surface of the phosphors...
May 22, 2018: Nanomaterials
https://www.readbyqxmd.com/read/29786653/role-for-cystathionine-%C3%AE-lyase-cse-in-an-ethanol-e-induced-lesion-in-fetal-brain-gsh-homeostasis
#15
Dhyanesh Patel, Marylatha Rathinam, Courtney Jarvis, Lenin Mahimainathan, George Henderson, Madhusudhanan Narasimhan
Earlier, we reported that gestational ethanol (E) can dysregulate neuron glutathione (GSH) homeostasis partially via impairing the EAAC1-mediated inward transport of Cysteine (Cys) and this can affect fetal brain development. In this study, we investigated if there is a role for the transulfuration pathway (TSP), a critical bio-synthetic point to supply Cys in E-induced dysregulation of GSH homeostasis. These studies utilized an in utero E binge model where the pregnant Sprague⁻Dawley (SD) rat dams received five doses of E at 3...
May 22, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29786609/comparison-of-trapped-charges-and-hysteresis-behavior-in-hbn-encapsulated-single-mos-sub-2-sub-flake-based-field-effect-transistors-on-sio-sub-2-sub-and-hbn-substrates
#16
Changhee Lee, Servin Rathi, Muhammad Atif Khan, Dongsuk Lim, Yunseob Kim, Sun Jin Yun, Doo-Hyeb Youn, Kenji Watanabe, Takashi Taniguchi, Gil-Ho Kim
Molybdenum disulfide (MoS<sub>2</sub>) based field effect transistors (FETs) are of considerable interest in electronic and opto-electronic applications but often have large hysteresis and threshold voltage instabilities. In this study, by using advanced transfer techniques, hexagonal boron nitride (hBN) encapsulated FETs based on a single, homogeneous and atomic-thin MoS<sub>2</sub> flake are fabricated on hBN and SiO<sub>2</sub> substrates...
May 22, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29786551/three-dimensional-cell-culture-from-evolution-to-revolution
#17
REVIEW
Sharmin Alhaque, Michael Themis, Hassan Rashidi
Recent advances in the isolation of tissue-resident adult stem cells and the identification of inductive factors that efficiently direct differentiation of human pluripotent stem cells along specific lineages have facilitated the development of high-fidelity modelling of several tissues in vitro Many of the novel approaches have employed self-organizing three-dimensional (3D) culturing of organoids, which offer several advantages over conventional two-dimensional platforms. Organoid technologies hold great promise for modelling diseases and predicting the outcome of drug responses in vitro Here, we outline the historical background and some of the recent advances in the field of three-dimensional organoids...
July 5, 2018: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/29786441/x-ray-photoelectron-spectroscopy-studies-of-nanoparticles-dispersed-in-static-liquid
#18
Luan Nguyen, Paul Pengcheng Tao, Huimin Liu, Mohamed Al-Hada, Matteo Amati, Hikmet Sezen, Luca Gregoratti, Yu Tang, Stephen D House, Franklin Feng Tao
For nanoparticles active for chemical and energy transformations in liquid environment, chemistries of surface or near-surface regions of these catalyst nanoparticles in liquid are crucial for fundamentally understanding their catalytic performances at a molecular level. Compared to catalysis at a solid-gas interface, there is very limited information on surface of these catalyst nanoparticles under working condition or during catalysis. Photoelectron spectroscopy is a surface-sensitive technique; however, it is challenging to study the surfaces of catalyst nanoparticles dispersed in liquid due to the short inelastic mean free path of photoelectrons travelling in liquid...
May 22, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29786430/galaxygpcrloop-template-based-and-ab-initio-structure-sampling-of-the-extracellular-loops-of-g-protein-coupled-receptors
#19
Jonghun Won, Gyu Rie Lee, Hahnbeom Park, Chaok Seok
The second extracellular loops (ECL2s) of G-protein-coupled receptors (GPCRs) are often involved in GPCR functions, and their structures have important implications in drug discovery. However, structure prediction of ECL2 is difficult because of its long length and the structural diversity among different GPCRs. In this study, a new ECL2 conformational sampling method involving both template-based and ab initio sampling was developed. Inspired by observation of similar ECL2 structures of closely related GPCRs, a template-based sampling method employing loop structure templates selected from the structure database was developed...
May 22, 2018: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/29786429/development-of-a-nanostructured-%C3%AE-mno2-carbon-paper-composite-for-removal-of-ni2-mn2-ions-by-electrosorption
#20
Pengju Li, Yang Gui, Daniel John Blackwood
Toxic metal ions, such as Ni2+ and Mn2+, in industrial waste streams are non-biodegradable and can cause damage to the human body. Electrochemical cleaning techniques are attractive as they offer more control and produce less sludge than chemical / biological approaches without the high pressures needed for membranes. Here nanoneedle structured α-MnO2/carbon fiber paper (CFP) composites were synthesized by a hydrothermal approach and used as electrodes for combined electro-adsorption and capacitive deionization removal of nickel and manganese ions from pseudo industrial waste streams...
May 22, 2018: ACS Applied Materials & Interfaces
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