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https://www.readbyqxmd.com/read/28938746/women-s-career-priority-is-associated-with-attitudes-towards-family-planning-and-ethical-acceptance-of-reproductive-technologies
#1
Michael K Simoni, Lin Mu, Stephen C Collins
STUDY QUESTION: Do women who place high importance on career success have different perceptions of pregnancy planning, delayed reproduction, and the ethical acceptability of ART than women with less emphasis on their career? SUMMARY ANSWER: Career-focused women place more importance on pregnancy planning, have greater confidence in delayed childbearing, and are more ethically accepting of donor gamete ART than women who do not place as much importance on career success...
October 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28938569/evaluation-of-autoantibody-signatures-in-meningioma-patients-using-human-proteome-arrays
#2
Shabarni Gupta, Shuvolina Mukherjee, Parvez Syed, Narendra Goud Pandala, Saket Choudhary, Vedita Anand Singh, Namrata Singh, Heng Zhu, Sridhar Epari, Santosh B Noronha, Aliasgar Moiyadi, Sanjeeva Srivastava
Meningiomas are one of the most common tumors of the Central nervous system (CNS). This study aims to identify the autoantibody biomarkers in meningiomas using high-density human proteome arrays (~17,000 full-length recombinant human proteins). Screening of sera from 15 unaffected healthy individuals, 10 individuals with meningioma grade I and 5 with meningioma grade II was performed. This comprehensive proteomics based investigation revealed the dysregulation of 489 and 104 proteins in grades I and II of meningioma, respectively, along with the enrichment of several signalling pathways, which might play a crucial role in the manifestation of the disease...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938513/increased-anterior-default-mode-network-homogeneity-in-first-episode-drug-naive-major-depressive-disorder-a-replication-study
#3
Wenbin Guo, Xilong Cui, Feng Liu, Jindong Chen, Guangrong Xie, Renrong Wu, Zhikun Zhang, Huafu Chen, Jingping Zhao
BACKGROUND: Abnormal default-mode network (DMN) homogeneity has been involved in the neurophysiology of major depressive disorder (MDD) with inconsistent findings. The inconsistency may be due to clinical and methodological variability, and the reproducibility of the findings is limited. The present study aimed to examine alterations of the DMN homogeneity in two independent samples of patients with first-episode, drug-naive MDD. METHODS: The samples included 59 patients with MDD and 31 comparison subjects from Sample 1 and 29 patients with MDD and 24 comparison subjects from Sample 2...
September 12, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28938470/genetic-disruption-of-21-hydroxylase-in-zebrafish-causes-interrenal-hyperplasia
#4
Helen Eachus, Andreas Zaucker, James A Oakes, Aliesha Griffin, Meltem Weger, Tülay Güran, Angela Taylor, Abigail Harris, Andy Greenfield, Jonathan L Quanson, Karl-Heinz Storbeck, Vincent T Cunliffe, Ferenc Müller, Nils Krone
Congenital adrenal hyperplasia is a group of common inherited disorders leading to glucocorticoid deficiency. Most cases are caused by 21-hydroxylase deficiency (21OHD). The systemic consequences of imbalanced steroid hormone biosynthesis due to severe 21OHD remains poorly understood. Therefore, we have developed a zebrafish model for 21OHD, which focuses on the impairment of glucocorticoid biosynthesis. A single 21-hydroxylase gene (cyp21a2) is annotated in the zebrafish genome based on sequence homology. Our in silico analysis of the Cyp21a2 protein sequence suggests a sufficient degree of similarity for the usage of zebrafish cyp21a2 to model aspects of human 21OHD in vivo...
September 13, 2017: Endocrinology
https://www.readbyqxmd.com/read/28938451/antibody-mediated-targeting-of-the-fgfr1c-isoform-increases-glucose-uptake-in-white-and-brown-adipose-tissue-in-male-mice
#5
Jo E Lewis, Ricardo J Samms, Scott Cooper, Jeni C Luckett, Alan C Perkins, James D Dunbar, Dennis P Smith, Paul J Emmerson, Andrew C Adams, Francis J P Ebling, Kostas Tsintzas
The increased prevalence of obesity and its cardiometabolic implications demonstrates the imperative to identify novel therapeutic targets able to effect meaningful metabolic changes in this population. Antibody-mediated targeting of fibroblast growth factor receptor 1c isoform (FGFR1c) has been shown to ameliorate hyperglycaemia and protect from diet- and genetically-induced obesity in rodents and non-human primates. However, it is currently unknown which tissue(s) contribute to this glucose lowering effect...
August 16, 2017: Endocrinology
https://www.readbyqxmd.com/read/28938435/the-role-of-sequential-bmp-signaling-in-directing-human-embryonic-stem-cells-to-bipotential-gonadal-cells
#6
Kirsi Sepponen, Karolina Lundin, Katri Knuus, Pia Väyrynen, Taneli Raivio, Juha S Tapanainen, Timo Tuuri
Context: Human gonads arise as a pair of epithelial ridges on the surface of intermediate mesoderm (IM)-derived mesonephros. Toxic environmental factors and mutations in various genes are known to disturb normal gonadal development, but due to a lack of suitable in vitro models, detailed studies characterizing the molecular basis of the observed defects have not been performed. Objective: Our objective was to establish an in vitro method for studying differentiation of bipotential gonadal progenitors using human embryonic stem cells (hESCs), and to investigate the role of bone morphogenetic protein (BMP) in gonadal differentiation...
August 29, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28938361/columellar-reconstruction-following-nasal-cpap-injury
#7
Catherine S Chang, Jordan W Swanson, Anthony Wilson, David W Low, Scott P Bartlett
Nasal continuous positive airway pressure (nCPAP) is utilized increasingly to treat pulmonary immaturity in premature neonates. Nasal injury is common with nCPAP use, with full thickness tissue loss at the columella among the most devastating complications.Columellar necrosis often imparts a full thickness injury to the overlying columellar skin, the medial crura of the lower lateral nasal cartilages, as well as the anteromedial inner nasal mucosal lining, and potentially the anterior septal cartilage. Consequently, the columella can become scarred and shortened...
September 15, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28938264/2016-neonatal-nurse-practitioner-workforce-survey-report-of-findings
#8
Suzanne Staebler, Robin Bissinger
The National Association of Neonatal Nurse Practitioners (NANNP) conducted its second workforce survey of certified neonatal nurse practitioners in the fall of 2016. National Association of Neonatal Nurse Practitioners partnered with the National Certification Corporation and the American Association of Nurse Practitioners to conduct this electronic survey, containing 69 questions and focusing on practice sites and total compensation packages (including benefits) and workforce deficits.Findings indicate a rising neonatal nurse practitioners (NNPs) position vacancy rate across the country...
October 2017: Advances in Neonatal Care: Official Journal of the National Association of Neonatal Nurses
https://www.readbyqxmd.com/read/28938186/electrochemiluminescence-resonance-energy-transfer-system-between-gnrs-and-ru-bpy-3-2-application-in-magnetic-aptasensor-for-%C3%AE-amyloid
#9
Hong Ke, Haifeng Sha, Yinfang Wang, Weiwei Guo, Xin Zhang, Zhiming Wang, Chusen Huang, Nengqin Jia
Electrochemiluminescent (ECL) assay has gradually drawn increasing interest in the biomedical analysis. This paper proposed a new methodology for ultrasensitive and facile detection of Alzheimer's disease marker β-amyloid (Aβ) by fabricating a sandwich-type ECL sensing platform. Herein, electrochemiluminescence resonance energy transfer (ECL-RET) was employed to determine Aβ concentration, which can be attributed to the quenching effect from RET between Ru(bpy)3(2+) and gold nanorods (GNRs) acting as ECL-RET electron donor and acceptor, respectively...
September 14, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28938165/a-novel-dopa-albumin-based-tissue-adhesive-for-internal-medical-applications
#10
Wenzhen Zhu, Yvonne Peck, Jabed Iqbal, Dong-An Wang
To date, existing tissue adhesives have various weak points in gluing kinetics and stability - particularly, in biocompatibility, which make most of them remain suboptimal for internal conditions. Herein, a novel mussel-inspired "BCD" tissue glue made of bovine serum albumin (BSA), citrate acid (CA) and dopamine was developed aiming at internal medical applications. BSA was employed as a natural and biocompatible macromolecular backbone; CA was introduced as a dual-functional intermediate to increase reactive carboxyl sites for engraftment of dopamine onto BSA backbone and also block the competing reactive amines from the proteinic backbone...
September 14, 2017: Biomaterials
https://www.readbyqxmd.com/read/28938162/characterization-of-wedge-waves-propagating-along-wedge-tips-with-defects
#11
Ming-I Chen, Seng-Po Tesng, Pei-Yuan Lo, Che-Hua Yang
Wedge waves are guided acoustic waves propagating along the tip of a wedge with the energy tightly confined near the wedge. Anti-symmetric flexural (ASF) modes are wedge waves with their particle motion anti-symmetric with the apex mid-plane. This study investigates the behaviors of ASF modes propagation along wedge tips with perfect and imperfect rectangular defects. Numerical finite element simulations and experimental measurements using a laser ultrasound technique are employed to explore the behaviors of ASF modes interacting with defects...
September 14, 2017: Ultrasonics
https://www.readbyqxmd.com/read/28937995/enzootic-mosquito-vector-species-at-equine-encephalitis-transmission-foci-in-the-rep%C3%A3%C2%BAblica-de-panam%C3%A3
#12
Rolando Torres, Rafael Samudio, Jean-Paul Carrera, Josue Young, Ricardo Márquez, Lisbeth Hurtado, Scott Weaver, Luis Fernando Chaves, Robert Tesh, Lorenzo Cáceres
The identification of mosquito vector species present at arboviral enzootic transmission foci is important to understand transmission eco-epidemiology and to propose and implement prevention and control strategies that reduce vector-borne equine encephalitis transmission. The goal of this study was to identify mosquito species potentially involved in the transmission of enzootic equine encephalitis, in relation to their abundance and diversity at three endemic regions in the República de Panamá. We sampled adult mosquitoes during the dry and rainy season of Panamá...
2017: PloS One
https://www.readbyqxmd.com/read/28937937/self-compassion-and-suicidal-behavior-in-college-students-serial-indirect-effects-via-depression-and-wellness-behaviors
#13
Jessica Kelliher Rabon, Fuschia M Sirois, Jameson K Hirsch
OBJECTIVE: College students may be at heightened risk for suicide and suicidal behavior due to maladaptive cognitive-emotional factors and failure to practice basic health behaviors. However, self-compassion and wellness behaviors may protect against risk. The relation between self-compassion and suicidal behavior and the contributing roles of depressive symptoms and wellness behaviors was examined. PARTICIPANTS: Participants were 365 undergraduate students. Data was collected in April 2015...
September 22, 2017: Journal of American College Health: J of ACH
https://www.readbyqxmd.com/read/28937910/loneliness-and-social-internet-use-pathways-to-reconnection-in-a-digital-world
#14
Rebecca Nowland, Elizabeth A Necka, John T Cacioppo
With the rise of online social networking, social relationships are increasingly developed and maintained in a digital domain. Drawing conclusions about the impact of the digital world on loneliness is difficult because there are contradictory findings, and cross-sectional studies dominate the literature, making causation difficult to establish. In this review, we present our theoretical model and propose that there is a bidirectional and dynamic relationship between loneliness and social Internet use. When the Internet is used as a way station on the route to enhancing existing relationships and forging new social connections, it is a useful tool for reducing loneliness...
September 1, 2017: Perspectives on Psychological Science: a Journal of the Association for Psychological Science
https://www.readbyqxmd.com/read/28937898/selective-reduction-of-talon-cusps-a-case-series
#15
Rona Leith, Anne C O'Connell
Talon cusps associated with permanent incisors are a rare occurrence but can cause numerous complications. When treatment is indicated options include radical or selective reduction of the accessory cusp, but there is no standard protocol for management. STUDY DESIGN: Patients referred to the Dublin Dental University Hospital for treatment of talon cusps were identified, contacted and consent obtained. Clinical notes, photographs and radiographs were retrospectively reviewed. RESULTS: Eleven patients with 14 talon cusps were identified...
September 22, 2017: Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/28937838/protein-supplements-pros-and-cons
#16
Jay Rabindra Kumar Samal, Indira R Samal
To provide a comprehensive analysis of the literature examining the pros and cons of protein supplementation, various articles on protein supplementation were obtained from Google Scholar, PubMed, and National Center for Biotechnology Information. Over the past few years, protein supplementation has become commonplace for gym-goers as well as for the public. A large segment of the general population relies on protein supplementation for meal replacement, weight reduction, and purported health benefits. These protein supplements have varying pros and cons associated with them, which are often overlooked by the public...
September 22, 2017: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/28937785/gaining-access-to-providing-medical-care-to-male-sport-teams-the-female-athletic-trainer-perspective
#17
Alicia Pike, Stephanie M Mazerolle, Jessica L Barrett
CONTEXT:   Female athletic trainers (ATs) can face barriers to employment within the profession. Although there is evidence for an increasing percentage of women in athletic training, the portion providing medical care to male sport teams within the professional sport and collegiate settings continues to be small. OBJECTIVE:   To investigate the experiences of female ATs when seeking employment with male sport teams within the Division I setting. DESIGN:   Qualitative study...
September 22, 2017: Journal of Athletic Training
https://www.readbyqxmd.com/read/28937769/an-efficient-molecular-approach-for-quantifying-solvent-mediated-interaction
#18
Hongguan Wu, Yu Li, Damir Kadirov, Shuangliang Zhao, Xiaohua Lu, Honglai Liu
The solvent-mediated interaction, or equivalently the depletion force, play a pivotal role in the processes, by which two objects in solution such as lock and key particles, antibody and antigen, macromolecule and substrate, are attracted to each other. The quantification of this interaction is important yet challenging since it depends on the microscopic solvent structure in the surrounding. Here, we report an efficient molecular approach for predicting the solvent-mediated interaction by combining the classical density functional theory with a reversible solvation thermodynamic circle...
September 22, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28937766/approach-toward-the-understanding-of-coupling-mechanism-for-edc-reagent-in-solvent-free-mechanosynthesis
#19
Aneta Wróblewska, Piotr Paluch, Ewelina Wielgus, Grzegorz Bujacz, Marta K Dudek, Marek J Potrzebowski
A unique approach in mechanosynthesis, joining solid-state NMR spectroscopy, X-ray crystallography, and theoretical calculations, is employed for the first time to study the mechanism of the formation of the C-N amide bond using EDC·HCl as a coupling reagent. It has been proved that EDC·HCl, which in the crystal lattice exists exclusively in the cyclic form (X-ray data), easily undergoes transformation to a pseudocyclic stable intermediate in reaction with carboxylic acid forming a low-melt phase (differential scanning calorimetry, solid-state NMR)...
September 22, 2017: Organic Letters
https://www.readbyqxmd.com/read/28937765/origin-of-substitution-mechanism-for-the-binding-of-organic-ligands-on-the-surface-of-cspbbr3-perovskite-nanocubes
#20
Vikash Kumar Ravi, Pralay K Santra, Niharika Joshi, Jeetender Chugh, Sachin Kumar Singh, Håkan Rensmo, Prasenjit Ghosh, Angshuman Nag
Optoelectronic properties of CsPbBr3 perovskite nanocubes (NCs) depend strongly on the interaction of the organic passivating molecules with the inorganic crystal. To understand this interaction, we employed a combination of synchrotron-based X-ray photoelectron spectroscopy (XPS), nuclear magnetic resonance (NMR) spectroscopy and first principles density functional theory (DFT) based calculations. XPS elucidated the internal structure of inorganic part in a layer-by-layer fashion, whereas, NMR characterized the organic ligands...
September 22, 2017: Journal of Physical Chemistry Letters
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