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https://www.readbyqxmd.com/read/29166752/immunotherapy-treatment-an-issue-for-metabolic-response
#1
Luca Tagliabue, Antonella Capozza, Claudio Maioli, Andrea Luciani, Anna M Ierardi, Gianpaolo Carrafiello
Since the beginning of second decade of this century, when it was introduced in many oncologic scenarios, immunotherapy has become an important tool in the management of a growing number of cancers. Engaging the host immune system in cancer therapy seems to be useful, improving not only progression free survival but also overall survival, until the achieving the goal that many advanced cancers, previously considered without effective treatment options, have now become successfully treatable. Moreover, considering the relatively recent introduction of these drugs in clinical scenarios and the continuous releasing of new drugs, large validated clinical experiences are lacking and many issues are today debated; by the way, the evaluation of the response to immune-therapy poses major concerns...
November 22, 2017: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29166725/-effect-and-related-mechanism-of-mirna-21-on-hydrogen-peroxide-induced-c-kit-cardiac-stem-cells-apoptosis
#2
R Z Zhao, Y Wang, W W Deng, B Shi, X P Long, Z L Wang, W M Chen
Objective: To explored the effect and related mechanism of miRNA-21 on hydrogen peroxide-induced C-kit(+) cardiac stem cells apoptosis. Methods: C-kit(+) cardiac stem cells were isolated from SD rats by the methods of enzyme digestion and magnetic bead. Cells were divided into the following experimental groups: (1) negative control mimics (NCM)group: cells were transfected with negative control miRNA-21 mimics for 48 hours; (2)mimics group: cells were transfected with miRNA-21 mimics for 48 hours; (3) NCM+ H(2)O(2) group: negative control miRNA-21 mimics were transfected into cells for 48 hours and then treated with 100 μmol H(2)O(2) for 2 hours; (4)mimics+ H(2)O(2) group: miRNA-21 mimics were transfected into cells for 48 hours and then treated with 100 μmol H(2)O(2) for 2 hours...
November 24, 2017: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/29166705/comprehensive-analysis-of-nine-monoamines-and-metabolites-in-small-amounts-of-peripheral-murine-c57bl-6j-tissues
#3
Joachim Nagler, Sonja C Schriever, Meri De Angelis, Paul T Pfluger, Karl-Werner Schramm
Monoamines, acting as hormones and neurotransmitters, play a critical role in multiple physiological processes ranging from cognitive function and mood to sympathetic nervous system activity, fight-or-flight response, or glucose homeostasis. In addition to brain and blood, monoamines are abundant in several tissues, and dysfunction in their synthesis or signaling is associated with various pathological conditions. It was our goal to develop a method to detect these compounds in peripheral murine tissues. In this study, we employed a high performance liquid chromatography method using electrochemical detection that allows not only detecting the catecholamines but a detailed analysis of nine monoamines and metabolites in murine tissues...
November 22, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29166661/ultraconserved-elements-uces-resolve-the-phylogeny-of-australasian-smurf-weevils
#4
Matthew H Van Dam, Athena W Lam, Katayo Sagata, Bradley Gewa, Raymond Laufa, Michael Balke, Brant C Faircloth, Alexander Riedel
Weevils (Curculionoidea) comprise one of the most diverse groups of organisms on earth. There is hardly a vascular plant or plant part without its own species of weevil feeding on it and weevil species diversity is greater than the number of fishes, birds, reptiles, amphibians and mammals combined. Here, we employ ultraconserved elements (UCEs) designed for beetles and a novel partitioning strategy of loci to help resolve phylogenetic relationships within the radiation of Australasian smurf-weevils (Eupholini)...
2017: PloS One
https://www.readbyqxmd.com/read/29166660/great-apes-are-sensitive-to-prior-reliability-of-an-informant-in-a-gaze-following-task
#5
Benjamin Schmid, Katja Karg, Josef Perner, Michael Tomasello
Social animals frequently rely on information from other individuals. This can be costly in case the other individual is mistaken or even deceptive. Human infants below 4 years of age show proficiency in their reliance on differently reliable informants. They can infer the reliability of an informant from few interactions and use that assessment in later interactions with the same informant in a different context. To explore whether great apes share that ability, in our study we confronted great apes with a reliable or unreliable informant in an object choice task, to see whether that would in a subsequent task affect their gaze following behaviour in response to the same informant...
2017: PloS One
https://www.readbyqxmd.com/read/29166617/spatiotemporal-proteomic-profiling-of-huntington-s-disease-inclusions-reveals-widespread-loss-of-protein-function
#6
Fabian Hosp, Sara Gutiérrez-Ángel, Martin H Schaefer, Jürgen Cox, Felix Meissner, Mark S Hipp, F-Ulrich Hartl, Rüdiger Klein, Irina Dudanova, Matthias Mann
Aggregation of polyglutamine-expanded huntingtin exon 1 (HttEx1) in Huntington's disease (HD) proceeds from soluble oligomers to late-stage inclusions. The nature of the aggregates and how they lead to neuronal dysfunction is not well understood. We employed mass spectrometry (MS)-based quantitative proteomics to dissect spatiotemporal mechanisms of neurodegeneration using the R6/2 mouse model of HD. Extensive remodeling of the soluble brain proteome correlated with insoluble aggregate formation during disease progression...
November 21, 2017: Cell Reports
https://www.readbyqxmd.com/read/29166602/mucus-detachment-by-host-metalloprotease-meprin-%C3%AE-requires-shedding-of-its-inactive-pro-form-which-is-abrogated-by-the-pathogenic-protease-rgpb
#7
Rielana Wichert, Anna Ermund, Stefanie Schmidt, Matthias Schweinlin, Miroslaw Ksiazek, Philipp Arnold, Katharina Knittler, Frederike Wilkens, Barbara Potempa, Björn Rabe, Marit Stirnberg, Ralph Lucius, Jörg W Bartsch, Susanna Nikolaus, Maren Falk-Paulsen, Philip Rosenstiel, Marco Metzger, Stefan Rose-John, Jan Potempa, Gunnar C Hansson, Peter J Dempsey, Christoph Becker-Pauly
The host metalloprotease meprin β is required for mucin 2 (MUC2) cleavage, which drives intestinal mucus detachment and prevents bacterial overgrowth. To gain access to the cleavage site in MUC2, meprin β must be proteolytically shed from epithelial cells. Hence, regulation of meprin β shedding and activation is important for physiological and pathophysiological conditions. Here, we demonstrate that meprin β activation and shedding are mutually exclusive events. Employing ex vivo small intestinal organoid and cell culture experiments, we found that ADAM-mediated shedding is restricted to the inactive pro-form of meprin β and is completely inhibited upon its conversion to the active form at the cell surface...
November 21, 2017: Cell Reports
https://www.readbyqxmd.com/read/29166449/caesarean-birth-rates-in-public-and-privately-funded-hospitals-a-cross-sectional-study
#8
Bruna Dias Alonso, Flora Maria Barbosa da Silva, Maria do Rosário Dias de Oliveira Latorre, Carmen Simone Grilo Diniz, Debra Bick
OBJECTIVE: To examine maternal and obstetric factors influencing births by cesarean section according to health care funding. METHODS: A cross-sectional study with data from Southeastern Brazil. Caesarean section births from February 2011 to July 2012 were included. Data were obtained from interviews with women whose care was publicly or privately funded, and from their obstetric and neonatal records. Univariate and multivariate analyses were conducted to generate crude and adjusted odds ratios (OR) with 95% confidence intervals (95%CI) for caesarean section births...
2017: Revista de Saúde Pública
https://www.readbyqxmd.com/read/29166384/neanderthal-hunting-strategies-inferred-from-mortality-profiles-within-the-abric-roman%C3%A3-sequence
#9
Juan Marín, Palmira Saladié, Antonio Rodríguez-Hidalgo, Eudald Carbonell
Ungulate mortality profiles are commonly used to study Neanderthal subsistence strategies. To assess the hunting strategies used by Neanderthals, we studied the ages at death of the cervids and equids found in levels E, H, I, Ja, Jb, K, L and M of the Abric Romaní sequence. These levels date between 43.2 ± 1.1 ka BP (14C AMS) and 54.5 ± 1.7 ka BP (U-series). The degree of eruption and development of the teeth and their wear stages were used to determine the ages of these animals at death, and mortality profiles were constructed using these data...
2017: PloS One
https://www.readbyqxmd.com/read/29166381/risk-score-for-the-prediction-of-severe-obesity-in-pediatric-craniopharyngiomas-relative-to-tumor-origin
#10
Danling Li, Jun Pan, Junxiang Peng, Shichao Zhang, Guanglong Huang, Xi'an Zhang, Yun Bao, Songtao Qi
BACKGROUND: We aimed to develop a risk score to improve the prediction of severe obesity in pediatric craniopharyngiomas (PCs). METHODS: 612 consecutive PCs were prospectively enrolled from 6 hospitals. Data from 404 participants were analyzed. Participants from 3 of the 6 hospitals (n=290) were used to develop a risk score. External validation of the developed risk score was conducted using the participants from the other 3 hospitals (n=114). Sequential logistic regression was used to develop and validate the risk score...
November 22, 2017: Pediatric Research
https://www.readbyqxmd.com/read/29166349/developing-end-of-training-entrustable-professional-activities-for-psychiatry-results-and-methodological-lessons
#11
John Q Young, Caitlin Hasser, Erick H Hung, Martin Kusz, Patricia S O'Sullivan, Colin Stewart, Andrea Weiss, Nancy Williams
PURPOSE: To develop entrustable professional activities (EPAs) for psychiatry and to demonstrate an innovative, validity-enhancing methodology that may be relevant to other specialties. METHOD: A national task force employed a three-stage process from May 2014 to February 2017 to develop EPAs for psychiatry. In stage 1, the task force used an iterative consensus-driven process to construct proposed EPAs. Each included a title, full description, and relevant competencies...
November 21, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/29166346/options-in-acellular-dermal-matrix-device-assembly
#12
Steven Sigalove
Prepectoral prosthetic breast reconstruction has become increasingly popular during the last several years. Original shortcomings and poor outcomes in the 1970s have been overcome with the use of the bioengineered breast concept-namely, use of improved form stable breast implants, autologous fat grafting, and acellular dermal matrices (ADMs). Careful use of these reconstructive tools combined with improved mastectomy skin flaps has lead to successful early outcomes. Prepectoral breast reconstruction mitigates the animation deformities and muscle tightness previously associated with dual-plane prosthetic breast reconstruction while at the same time producing reproducible and outstanding aesthetic outcomes...
December 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29166297/assessing-patients-perceptions-of-safety-culture-in-the-hospital-setting-development-and-initial-evaluation-of-the-patients-perceptions-of-safety-culture-scale
#13
Clara Monaca, Beate Bestmann, Martina Kattein, Daria Langner, Hardy Müller, Tanja Manser
OBJECTIVES: Both, patient satisfaction and hospital safety culture have been recognized as key characteristics of healthcare quality and patient safety. Thus, both characteristics are measured widely to support quality and safety improvement efforts. However, because safety culture surveys focus exclusively on the perspective of hospital staff, the complimentary information to be gained from patients' perceptions of safety culture has received little research attention so far. We aimed to develop a measure explicitly focusing on patients' perceptions of safety culture in the hospital setting and perform an initial evaluation of its measurement properties...
November 21, 2017: Journal of Patient Safety
https://www.readbyqxmd.com/read/29166254/proactive-and-early-aggressive-wound-management-a-shift-in-strategy-developed-by-a-consensus-panel-examining-the-current-science-prevention-and-management-of-acute-and-chronic-wounds
#14
Gregory A Bohn, Gregory S Schultz, Brock A Liden, Michael N Desvigne, Eric J Lullove, Igor Zilberman, Mary B Regan, Marta Ostler, Karen Edwards, Georgia M Arvanitis, Jodi F Hartman
Normal wound healing is accomplished through a series of well-coordinated, progressive events with overlapping phases. Chronic wounds are described as not progressing to healing or not being responsive to management in a timely manner. A consensus panel of multidisciplinary wound care professionals was assembled to (1) educate wound care practitioners by identifying key principles of the basic science of chronic wound pathophysiology, highlighting the impact of metalloproteinases and biofilms, as well as the role of the extracellular matrix; and (2) equip practitioners with a systematic strategy for the prevention and healing of acute injuries and chronic wounds based upon scientific evidence and the panel members' expertise...
November 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/29166213/relationship-of-ptsd-with-impulsivity-dimensions-while-controlling-the-effect-of-anxiety-and-depression-in-a-sample-of-inpatients-with-alcohol-use-disorder
#15
Cuneyt Evren, Gokhan Umut, Muge Bozkurt, Bilge Evren
OBJECTIVE: The aim of the present study was to evaluate the relationship of posttraumatic stress disorder (PTSD) with impulsivity dimensions while controlling the effect of anxiety and depression in a sample of inpatients with alcohol use disorder (AUD). METHODS: Participants were 190 male patients admitted to a specialized center for substance use disorders within a six month period. Participants were evaluated with the State-Trait Anxiety Inventory (STAI), Beck Depression Inventory (BDI), the Short Form Barratt Impulsiveness Scale (BIS-11-SF), the Traumatic Experiences Checklist (TEC) and PTSD Checklist Civilian version (PCL-C)...
November 22, 2017: Journal of Dual Diagnosis
https://www.readbyqxmd.com/read/29166200/effect-of-audiovisual-distraction-on-distress-and-oxygenation-status-in-children-receiving-aerosol-therapy
#16
Ni Luh Putu Shinta Devi, Nani Nurhaeni, Happy Hayati
Aerosol therapy, a treatment for children with disorders of the respiratory system, often causes distress, especially in young children. Distress during aerosol therapy can decrease the effectiveness of the treatment. This study aimed to determine the effect of audiovisual distraction on distress levels and oxygenation status (measured by oxygen saturation and respiratory frequency) in children who receive aerosol therapy for disorders of the respiratory system. A quasi-experimental design was employed, specifically a non-equivalent control group, pre-test-post-test design...
2017: Compr Child Adolesc Nurs
https://www.readbyqxmd.com/read/29166187/cognitive-behavioral-and-family-psychoeducational-therapies-for-adolescent-inmates-experiencing-anxiety-in-a-narcotics-correctional-facility
#17
Madepan Mulia, Budi Anna Keliat, Ice Yulia Wardani
Illicit substance use is becoming a major global issue. In Indonesia, inmates imprisoned for illicit substance offences accounted for 40% of the total inmate population. This study aimed to identify the effects of cognitive behavioral and family psychoeducational therapies on inmates' anxiety in the narcotics correctional facility. Quasi-experimental pre-test-post-test with control group was employed in this study. Intervention Group 1 received a general nursing intervention whereas Intervention Group 2 received a combination of general nursing intervention with cognitive behavioral and family psychoeducational therapies...
2017: Compr Child Adolesc Nurs
https://www.readbyqxmd.com/read/29166181/sensitivity-specificity-and-accuracy-of-kramer-examination-of-neonatal-jaundice-comparison-with-total-bilirubin-serum
#18
Zesi Aprillia, Dewi Gayatri, Fajar Tri Waluyanti
Neonatal jaundice often occurs in the first week after birth. Early detection of neonatal jaundice can prevent kernicterus as a complication of high levels of bilirubin in neonates. Visual assessment is one of the examinations introduced by Kramer to assess the presence of neonatal jaundice. The purpose of this study was to determine the sensitivity, specificity, and accuracy of Kramer's visual assessment in the examination of neonatal jaundice. This study used cross-sectional design to examine 102 infants, with the sample selected by the convenience sampling method...
2017: Compr Child Adolesc Nurs
https://www.readbyqxmd.com/read/29166125/rural-urban-differences-in-unpaid-caregivers-of-adults
#19
Elizabeth Crouch, Janice Probst, Kevin Bennett
INTRODUCTION:   Rural–urban differences in the characteristics of unpaid caregivers of adults in the USA were explored. METHODS:   Using 'Caregiving in the U.S. 2015', a survey fielded by the National Alliance for Caregiving and AARP, a national examination of rural caregivers (n=1352) is presented. RESULTS:   Rural caregivers reported lower socioeconomic status than urban caregivers (measured by income, education, and employment), suggesting greater likelihood of caregiver strain...
November 2017: Rural and Remote Health
https://www.readbyqxmd.com/read/29166114/communication-recovering-the-flat-plane-condition-in-electronic-structure-theory-at-semi-local-dft-cost
#20
Akash Bajaj, Jon Paul Janet, Heather J Kulik
The flat-plane condition is the union of two exact constraints in electronic structure theory: (i) energetic piecewise linearity with fractional electron removal or addition and (ii) invariant energetics with change in electron spin in a half filled orbital. Semi-local density functional theory (DFT) fails to recover the flat plane, exhibiting convex fractional charge errors (FCE) and concave fractional spin errors (FSE) that are related to delocalization and static correlation errors. We previously showed that DFT+U eliminates FCE but now demonstrate that, like other widely employed corrections (i...
November 21, 2017: Journal of Chemical Physics
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