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https://www.readbyqxmd.com/read/28749624/synthesis-characterization-and-evaluation-of-cytotoxic-effects-of-novel-hybrid-steroidal-heterocycles-as-peg-based-nanoparticles
#1
Mervat M Abd Elhalim, Nasser S M Ismail, Shaymaa M M Yahya, Yasmin Y Omar, Ahmed A Abd Rabou, Deena S Lasheen, Mahmoud F Zawrah, Gamal A Elmegeed
Anticancer agents featuring hybrid molecules can improve effectiveness and diminish drug resistance. The current study aimed to introduce newly synthesized heterocyclic steroids of promising anticancer effects loaded in polyethylene glycol (PEG)•based nanoparticles form. Several heterocyclic steroids (1-9) were synthesized via multicomponent reactions (MCRs) and confirmed via the analytical and spectral data. Compounds 1, 2, 3, 4, 5, 6, 7 and 9, were investigated individually in their free and PEG based nano-size hybrid forms as anticancer agents against three human cell lines: hepatocellular carcinoma cells (HepG2); breast cancer cells (MCF-7); and colon cancer cells (HCT116)...
July 27, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28749603/protection-motivation-theory-in-predicting-intention-to-receive-cervical-cancer-screening-in-rural-chinese-women
#2
Yang Bai, Qing Liu, Xinguang Chen, Yanduo Gao, Huiyun Gong, Xiaodong Tan, Min Zhang, Jiyu Tuo, Yuling Zhang, Qunying Xiang, Fenghua Deng, Guiling Liu
OBJECTIVE: Despite the significance of cervical cancer screening, motivating more women to participate remains a challenge in resource-limited settings. In this study, we tested the protection motivation theory (PMT) in predicting screening intentions. METHODS: Participants were women from Wufeng, a typical rural county in China. Participants (n=3000) with no cervical cancer history were recruited from 10 randomly selected villages. As mediating variables, six PMT constructs (Perceived Risk, Fear Arousal, Perceived Severity, Response Efficacy, Response Cost and Self-Efficacy) were measured using the standardized questionnaire...
July 27, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/28749495/characterization-of-a-highly-efficient-antibiotic-degrading-metallo-%C3%AE-lactamase-obtained-from-an-uncultured-member-of-a-permafrost-community
#3
Marcelo Monteiro Pedroso, Christopher Selleck, Charmaine Enculescu, Jeffrey R Harmer, Nataša Mitić, Whitney R Craig, Waleed Helweh, Philip Hugenholtz, Gene W Tyson, David L Tierney, James A Larrabee, Gerhard Schenk
Antibiotic resistance is a major global health problem, one that threatens to derail the benefits garnered from arguably the greatest success of modern medicine, the discovery of antibiotics. Among the most potent agents contributing to antibiotic resistance are metallo-β-lactamases (MBLs). The discovery of MBL-like enzymes in microorganisms that are not in contact with the human population is of particular concern as these proteins already have the in-built capacity to inactivate antibiotics, even though they may not need MBL activity for their survival...
July 27, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28749478/molecular-autopsy-in-maternal-fetal-medicine
#4
Hanan E Shamseldin, Wesam Kurdi, Fatima Almusafri, Maha Alnemer, Alya Alkaff, Zeneb Babay, Amal Alhashem, Maha Tulbah, Nada Alsahan, Rubina Khan, Bahauddin Sallout, Elham Al Mardawi, Mohamed Zain Seidahmed, Niema Meriki, Yasser Alsaber, Alya Qari, Ola Khalifa, Wafaa Eyaid, Zuhair Rahbeeni, Ahmed Kurdi, Mais Hashem, Tarfa Alshidi, Eman Al-Obeid, Firdous Abdulwahab, Niema Ibrahim, Nour Ewida, Karen El-Akouri, Mariam Al Mulla, Tawfeg Ben-Omran, Matthias Pergande, Sebahattin Cirak, Saeed Al Tala, Ranad Shaheen, Eissa Faqeih, Fowzan S Alkuraya
PurposeThe application of genomic sequencing to investigate unexplained death during early human development, a form of lethality likely enriched for severe Mendelian disorders, has been limited.MethodsIn this study, we employed exome sequencing as a molecular autopsy tool in a cohort of 44 families with at least one death or lethal fetal malformation at any stage of in utero development. Where no DNA was available from the fetus, we performed molecular autopsy by proxy, i.e., through parental testing.ResultsPathogenic or likely pathogenic variants were identified in 22 families (50%), and variants of unknown significance were identified in further 15 families (34%)...
July 27, 2017: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/28749450/evaluation-of-shifted-excitation-raman-difference-spectroscopy-and-comparison-to-computational-background-correction-methods-applied-to-biochemical-raman-spectra
#5
Eliana Cordero, Florian Korinth, Clara Stiebing, Christoph Krafft, Iwan W Schie, Jürgen Popp
Raman spectroscopy provides label-free biochemical information from tissue samples without complicated sample preparation. The clinical capability of Raman spectroscopy has been demonstrated in a wide range of in vitro and in vivo applications. However, a challenge for in vivo applications is the simultaneous excitation of auto-fluorescence in the majority of tissues of interest, such as liver, bladder, brain, and others. Raman bands are then superimposed on a fluorescence background, which can be several orders of magnitude larger than the Raman signal...
July 27, 2017: Sensors
https://www.readbyqxmd.com/read/28749432/screening-hepatotoxic-components-in-euodia-rutaecarpa-by-uhplc-qtof-ms-based-on-the-spectrum-toxicity-relationship
#6
Jian Liang, Yang Chen, Gang Ren, Wei Dong, Min Shi, Li Xiong, Jiankang Li, Jiahao Dong, Fei Li, Jinbin Yuan
Euodia rutaecarpa is a common traditional Chinese medicine (TCM) in clinical practice, having the ability to suppress pain and cease coughing; however, with the increasing reports showing that it is toxic, particularly hepatotoxic, the concerns raised by what cause its toxicity is growing. In the current study, an analysis method based on the spectrum effect has been employed to screen the major hepatotoxic components in Euodia rutaecarpa so that the toxic material's basis would be elucidated. A fingerprinting method of the Euodia rutaecarpa extracts (which were petroleum ether, chloroform, ethyl acetate, n-butanol, and water) using ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometer (UHPLC-QTOF/MS) has been developed...
July 27, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28749431/iot-service-clustering-for-dynamic-service-matchmaking
#7
Shuai Zhao, Le Yu, Bo Cheng, Junliang Chen
As the adoption of service-oriented paradigms in the IoT (Internet of Things) environment, real-world devices will open their capabilities through service interfaces, which enable other functional entities to interact with them. In an IoT application, it is indispensable to find suitable services for satisfying users' requirements or replacing the unavailable services. However, from the perspective of performance, it is inappropriate to find desired services from the service repository online directly. Instead, clustering services offline according to their similarity and matchmaking or discovering service online in limited clusters is necessary...
July 27, 2017: Sensors
https://www.readbyqxmd.com/read/28749417/modeling-the-effect-of-physical-activity-on-obesity-in-china-evidence-from-the-longitudinal-china-health-and-nutrition-study-1989-2011
#8
Tao Zhang
Although physical activity has been widely recognized as an important influential factor in determining the risk of obesity, the results in the existing literature empirically examining such issue are mixed. Especially for China, relevant studies are rarely found. One aim of this study is to test the direction of effects between obesity and physical activity. It uses longitudinal data to investigate the relationship and causality between physical activity and obesity for both children and adults in China. The longitudinal data and dynamic panel model used here can yield more solid results than the other studies employing cross-sectional data, particularly considering strict endogeneity and self-selection...
July 27, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28749410/awareness-of-the-risk-of-exposure-to-infectious-material-and-the-behaviors-of-polish-paramedics-with-respect-to-the-hazards-from-blood-borne-pathogens-a-nationwide-study
#9
Anna Garus-Pakowska, Mariusz Górajski, Franciszek Szatko
(1) Background: To determine paramedics' frequency of contact with blood and other body fluids, as well as the analysis of knowledge of paramedics about blood-borne infections, their attitudes to patients infected with blood-borne viruses, and the post-exposure procedures implemented by paramedics; (2) Methods: An anonymous questionnaire among 190 paramedics working in various health care facilities in Poland (adjusted response rate, 76.3%); (3) Results: 78% of paramedics had contact with potentially infectious material at least several times a week...
July 27, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28749361/output-feedback-control-of-unknown-linear-discrete-time-systems-with-stochastic-measurement-and-process-noise-via-approximate-dynamic-programming
#10
Jun-Sheng Wang, Guang-Hong Yang
This paper studies the optimal output-feedback control problem for unknown linear discrete-time systems with stochastic measurement and process noise. A dithered Bellman equation with the innovation covariance matrix is constructed via the expectation operator given in the form of a finite summation. On this basis, an output-feedback-based approximate dynamic programming method is developed, where the terms depending on the innovation covariance matrix are available with the aid of the innovation covariance matrix identified beforehand...
July 25, 2017: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/28749354/real-time-cloth-rendering-with-fiber-level-detail
#11
Kui Wu, Cem Yuksel
Modeling cloth with fiber-level geometry can produce highly realistic details. However, rendering fiber-level cloth models not only has a high memory cost but it also has a high computation cost even for offline rendering applications. In this paper we present a real-time fiber-level cloth rendering method for current GPUs. Our method procedurally generates fiber-level geometric details on-the-fly using yarn-level control points for minimizing the data transfer to the GPU. We also reduce the rasterization operations by collectively representing the fibers near the center of each ply that form the yarn structure...
July 26, 2017: IEEE Transactions on Visualization and Computer Graphics
https://www.readbyqxmd.com/read/28749347/approximate-message-passing-reconstruction-of-quantitative-acoustic-microscopy-images
#12
J-H Kim, J Mamou, P R Hill, N Canagarajah, D Kouame, A Basarab, A Achim
A novel framework for compressive sensing (CS) data acquisition and reconstruction in quantitative acoustic microscopy (QAM) is presented. Three different compressive sensing patterns, adapted to the specifics of QAM systems, were investigated as an alternative to the current raster-scanning approach. They consist of diagonal sampling, a row random and a spiral scanning pattern and they can all significantly reduce both the acquisition time and the amount of sampled data. For subsequent image reconstruction, we design and implement an innovative technique, whereby a recently proposed approximate message passing (AMP) method is adapted to account for the underlying data statistics...
July 24, 2017: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/28749245/advances-in-our-understanding-of-immunization-and-vaccines-for-patients-with-systemic-lupus-erythematosus
#13
Nicola Luigi Bragazzi, Abdulla Watad, Kassem Sharif, Mohammad Adawi, Gali Aljadeff, Howard Amital, Yehuda Shoenfeld
INTRODUCTION: Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease. In SLE, immune system dysfunction is postulated to result by virtue of the disease itself as well as by the impact of treatment modalities employed. A myriad of immune dysregulations occur including complement system dysfunction among others. Infectious agents are known to complicate the disease course in close to 25-45 % of SLE patients. METHODS: In this review a discussion of the immunogenicity and safety of viral and bacterial vaccinations in SLE was performed...
July 27, 2017: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/28749197/cardiovascular-benefits-and-safety-of-non-insulin-medications-used-in-the-treatment-of-type-2-diabetes-mellitus
#14
Srikanth Yandrapalli, George Jolly, Adam Horblitt, Abdallah Sanaani, Wilbert S Aronow
Diabetes mellitus is a growing in exponential proportions. If the current growth trend continues, it may result in every third adult in the United States having diabetes mellitus by 2050, and every 10(th) adult worldwide. Type 2 diabetes mellitus (T2DM) confers a 2- to 3-fold increased risk of cardiovascular (CV) events compared with non-diabetic patients, and CV mortality is responsible for around 80% mortality in this population. Patients with T2DM can have other features of insulin resistance-metabolic syndrome like hypertension, lipid abnormalities, and obesity which are all associated with increased CV disease and stroke risk even in the absence of T2DM...
July 27, 2017: Postgraduate Medicine
https://www.readbyqxmd.com/read/28749161/self-employment-personal-values-and-varieties-of-happiness-unhappiness
#15
Peter Warr
This study compares personal values and forms of happiness between self-employed workers and those employed in an organization. Values are examined through Schwartz's (1999) established model, and happiness is measured in terms of personal flourishing and both job-specific and general hedonic well-being. In two nationally representative samples, self-employed workers are found to value self-direction and stimulation in their lives to a significantly greater degree than do organizational employees, but not to differ in other types of value...
July 27, 2017: Journal of Occupational Health Psychology
https://www.readbyqxmd.com/read/28749122/tobacco-use-and-effects-of-professional-advice-on-smoking-cessation-among-youth-in-india
#16
Siddardha G Chandrupatla, Mary Tavares, Zuhair S Natto
Objective: Healthcare professionals and addiction programs play important roles in tobacco use prevention and cessation activities. In this study, we analyzed the prevalence of tobacco use and the impact of smoking cessation advice through programs/professionals among a nationally representative sample of youth in India. Methods: The data were obtained from the Global Youth Tobacco Survey (GYTS) 2009 dataset from a nationally representative school based survey of 8th to 10th grade students in India (n=14,543)...
July 27, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28749101/barriers-to-cervical-cancer-and-breast-cancer-screening-uptake-in-low-income-and-middle-income-countries-a-systematic-review
#17
Rakibul M Islam, Baki Billah, Md Nassif Hossain, John Oldroyd
Background: Cervical cancer (CCa) and breast cancer (BCa) are the two leading cancers in women worldwide. Early detection and education to promote early diagnosis and screening of CCa and BCa greatly increases the chances for successful treatment and survival. Screening uptake for CCa and BCa in low and middle - income countries (LMICs) is low, and is consequently failing to prevent these diseases. We conducted a systematic review to identify the key barriers to CCa and BCa screening in women in LMICs. Methods: We performed a systematic literature search using Ovid MEDLINE, EMBASE, PsycINFO, SCOPUS, CINHAL Plus, and Google scholar to retrieve all English language studies from inception to 2015...
July 27, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28749092/ketamine-for-depression-4-in-what-dose-at-what-rate-by-what-route-for-how-long-and-at-what-frequency
#18
Chittaranjan Andrade
BACKGROUND: Ketamine, administered in subanesthetic doses, is an effective off-label treatment for severe and even treatment-refractory depression; however, despite dozens of studies across nearly 2 decades of research, there is no definitive guidance on matters related to core practice issues. METHODS: This article presents a qualitative review and summary about what is known about ketamine dosing, rate of administration, route of administration, duration of treatment, and frequency of sessions...
July 25, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28749065/concise-review-the-high-cost-of-high-tech-medicine-planning-ahead-for-market-access
#19
REVIEW
Dawn Driscoll, Stephanie Farnia, Panos Kefalas, Richard T Maziarz
Cellular therapies and other regenerative medicines are emerging as potentially transformative additions to modern medicine, but likely at a staggering financial cost. Public health care systems' budgets are already strained by growing and aging populations, and many private insurer's budgets are equally stretched. The current systems that most payers employ to manage their cash flow are not structured to absorb a sudden onslaught of very expensive prescriptions for a large portion of their covered population...
August 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28749016/trends-in-study-design-and-the-statistical-methods-employed-in-a-leading-general-medicine-journal
#20
M Gosho, Y Sato, K Nagashima, S Takahashi
WHAT IS KNOWN AND OBJECTIVE: Study design and statistical methods have become core components of medical research, and the methodology has become more multifaceted and complicated over time. The study of the comprehensive details and current trends of study design and statistical methods is required to support the future implementation of well-planned clinical studies providing information about evidence-based medicine. Our purpose was to illustrate study design and statistical methods employed in recent medical literature...
July 27, 2017: Journal of Clinical Pharmacy and Therapeutics
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