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https://www.readbyqxmd.com/read/28340482/the-effect-of-interprofessional-team-based-learning-among-nursing-students-a-quasi-experimental-study
#1
Arkers Kwan Ching Wong, Frances Kam Yuet Wong, Lap Ki Chan, Namkiu Chan, Fraide A Ganotice, Jacqueline Ho
BACKGROUND: Although interprofessional education has received attention in recent years as a means of providing opportunities for health-care professionals to learn with, from and about other disciplines and enhance the quality of patient care, evidence of its effectiveness is limited. Interprofessional team-based learning was introduced to make it possible for students in different healthcare disciplines to interact with each other, and to prepare them to function effectively within a team in their future career...
March 9, 2017: Nurse Education Today
https://www.readbyqxmd.com/read/28340475/irinotecan-upregulates-fibroblast-growth-factor-receptor-3-expression-in-colorectal-cancer-cells-which-mitigates-irinotecan-induced-apoptosis
#2
Zeynep N Erdem, Stefanie Schwarz, Daniel Drev, Christine Heinzle, Andrea Reti, Petra Heffeter, Xenia Hudec, Klaus Holzmann, Bettina Grasl-Kraupp, Walter Berger, Michael Grusch, Brigitte Marian
BACKGROUND: Irinotecan (IRI) is an integral part of colorectal cancer (CRC) therapy, but response rates are unsatisfactory and resistance mechanisms are still insufficiently understood. As fibroblast growth factor receptor 3 (FGFR3) mediates essential survival signals in CRC, it is a candidate gene for causing intrinsic resistance to IRI. METHODS: We have used cell line models overexpressing FGFR3 to study the receptor's impact on IRI response. For pathway blockade, a dominant-negative receptor mutant and a small molecule kinase inhibitor were employed...
March 21, 2017: Translational Oncology
https://www.readbyqxmd.com/read/28340466/a-flexible-and-disposable-battery-powered-by-bacteria-using-eyeliner-coated-paper-electrodes
#3
Ramya Veerubhotla, Debabrata Das, Debabrata Pradhan
Herein, an environment friendly paper-based biobattery is demonstrated that yields a power of 12.5W/m(3). Whatman filter papers were used not only as support for electrode fabrication but also as separator of the biobattery. To provide electrical conductivity to the paper-based cathode and anode, commercially available eyeliner containing carbon nanoparticles and Fe3O4 was directly employed as conductive ink without any binder. With an instant start-up, the as-fabricated biocompatible electrodes could hold bacteria in an active form at the anode allowing chemical oxidation of organic fuel producing current...
March 9, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28340459/transcriptional-profiling-of-porcine-granulosa-cells-exposed-to-2-3-7-8-tetrachlorodibenzo-p-dioxin
#4
Agnieszka Sadowska, Anna Nynca, Monika Ruszkowska, Lukasz Paukszto, Kamil Myszczynski, Karina Orlowska, Sylwia Swigonska, Tomasz Molcan, Jan P Jastrzebski, Renata E Ciereszko
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a toxic man-made chemical compound contaminating the environment. An exposure of living organisms to TCDD may result in numerous disorders, including reproductive pathologies. The aim of the current study was to examine the effects of TCDD on the transcriptome of porcine granulosa cell line AVG-16. By employing next-generation sequencing (NGS) we aimed to identify genes potentially involved in the mechanism of TCDD action and toxicity in porcine granulosa cells...
March 16, 2017: Chemosphere
https://www.readbyqxmd.com/read/28340456/macroscopic-and-microscopic-investigation-of-adsorption-and-precipitation-of-zn-on-%C3%AE-alumina-in-the-absence-and-presence-of-as
#5
Yu-Jun Wang, Ting-Ting Fan, Cun Liu, Wei Li, Meng-Qiang Zhu, Jian-Xin Fan, Hua Gong, Dong-Mei Zhou, Donald L Sparks
Contaminants zinc (Zn) and arsenate (As) often coexist in soils. However, little is known concerning the impacts of coexisting As on Zn adsorption and precipitation on soil minerals. In the present study, adsorption and precipitation of Zn on γ-alumina in the absence and presence of arsenate was investigated employing batch experiments and Extended X-ray Absorption Fine Structure (EXAFS) spectroscopy. Results indicated that Zn formed edge-sharing tetrahedral surface complexes at pH 5.5 and Zn-Al LDH-like (layered double hydroxide) precipitates at pH 7...
March 21, 2017: Chemosphere
https://www.readbyqxmd.com/read/28340408/ongoing-evolution-of-pseudomonas-aeruginosa-pao1-sublines-complicates-studies-of-dna-damage-repair-and-tolerance
#6
Julia Sidorenko, Tatjana Jatsenko, Maia Kivisaar
Sublines of the major P. aeruginosa reference strain PAO1 are derivatives of the original PAO1 isolate, which are maintained in laboratories worldwide. These sublines display substantial genomic and phenotypic variation due to ongoing microevolution. Here, we examined four sublines, MPAO1, PAO1-L, PAO1-DSM and PAO1-UT, originated from different laboratories, and six DNA polymerase-deficient mutants from the P. aeruginosa MPAO1 transposon library for their employment in elucidation of DNA damage repair and tolerance mechanisms in P...
March 16, 2017: Mutation Research
https://www.readbyqxmd.com/read/28340406/a-local-adjustment-strategy-for-the-initialization-of-dynamic-causal-modelling-to-infer-effective-connectivity-in-brain-epileptic-structures
#7
Wentao Xiang, Ahmad Karfoul, Huazhong Shu, Régine Le Bouquin Jeannès
This paper addresses the question of effective connectivity in the human cerebral cortex in the context of epilepsy. Among model based approaches to infer brain connectivity, spectral Dynamic Causal Modelling is a conventional technique for which we propose an alternative to estimate cross spectral density. The proposed strategy we investigated tackles the sub-estimation of the free energy using the well-known variational Expectation-Maximization algorithm highly sensitive to the initialization of the parameters vector by a permanent local adjustment of the initialization process...
March 7, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28340400/pharmacoinformatics-exploration-of-polyphenol-oxidases-leading-to-novel-inhibitors-by-virtual-screening-and-molecular-dynamic-simulation-study
#8
Mubashir Hassan, Qamar Abbas, Zaman Ashraf, Ahmed A Moustafa, Sung-Yum Seo
Polyphenol oxidases (PPOs)/tyrosinases are metal-dependent enzymes and known as important targets for melanogenesis. Although considerable attempts have been conducted to control the melanin-associated diseases by using various inhibitors. However, the exploration of the best anti-melanin inhibitor without side effect still remains a challenge in drug discovery. In present study, protein structure prediction, ligand-based pharmacophore modeling, virtual screening, molecular docking and dynamic simulation study were used to screen the strong novel inhibitor to cure melanogenesis...
March 15, 2017: Computational Biology and Chemistry
https://www.readbyqxmd.com/read/28340397/quantification-of-hydrocarbon-species-on-surfaces-by-combined-microbalance-ftir
#9
Andrew I McNab, Tom Heinze, Alan J McCue, Davide Dionisi, James A Anderson
Absorption coefficients for the asymmetric stretching modes of CH3 and CH2 groups formed by adsorbing alkyl chained species from the vapour phase onto two different adsorbents; a γ-alumina support material and a supported metal catalyst have been determined using a custom made thermogravimetric-infrared cell. Results show that despite variations in the individually calculated absorption coefficients (ca. ±20%), the ratio of the absorption coefficients (CH2:CH3) remained consistent despite employing adsorbates of varying chain length and functionality, and despite the choice of adsorbents which exhibited different surface areas and light scattering characteristics...
March 16, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28340392/-237-np-analytical-method-using-239-np-tracers-and-application-to-a-contaminated-nuclear-disposal-facility
#10
Mathew S Snow, Samuel S Morrison, Sue B Clark, John E Olson, Matthew G Watrous
Environmental (237)Np analyses are challenged by low (237)Np concentrations and lack of an available yield tracer; we report a rapid, inexpensive (237)Np analytical approach employing the short lived (239)Np (t1/2 = 2.3 days) as a chemical yield tracer followed by (237)Np quantification using inductively coupled plasma-mass spectrometry. (239)Np tracer is obtained via separation from a (243)Am stock solution and standardized using gamma spectrometry immediately prior to sample processing. Rapid digestions using a commercial, 900 W "Walmart" microwave and Parr microwave vessels result in 99...
March 21, 2017: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/28340385/experimental-study-of-polyethylene-pyrolysis-and-combustion-over-hzsm-5-husy-and-mcm-41
#11
Que Huang, Changcheng Liu, Ruichao Wei, Jian Wang
The effects of temperatures, catalysts, and catalyst contents on polyethylene (PE) pyrolysis were investigated by using single-photon ionization time-of-flight mass spectrometry (SPI-TOFMS). The mass spectra of pyrolyzed PE and PE/catalysts from 300°C to 800°C illustrate that the pyrolysis reactions were apparently promoted and varied by introducing HZSM-5, HUSY, and MCM-41. As microporous catalysts, HZSM-5 and HUSY were found to accelerate the BTX formation at 400°C, which could not be observed for pure PE until 800°C...
March 14, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28340379/knockdown-of-ska1-gene-inhibits-cell-proliferation-and-metastasis-in-human-adenoid-cystic-carcinoma
#12
Li-Juan Zhao, Hong-Li Yang, Ke-Yi Li, Yue-Hua Gao, Kai Dong, Zhong-Hao Liu, Le-Xin Wang, Bin Zhang
The spindle and kinetochore-associated complex subunit 1(SKA1) is a newly discovered gene, which has been associated with mitosis and tumorigenesis. However, its role insalivary adenoid cystic carcinoma (SACC) is still unknown, and the invasive and metastatic mechanism in SACC is still unclear. To explore the molecular mechanism of SKA1 in the process of malignant proliferation and metastasis in adenoid cystic cancer (ACC) cells, we employed lentivirus-mediated short hairpin RNA to knockdown SKA1 in SACC-83 cells...
March 21, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28340369/degradation-of-diclofenac-by-uv-activated-persulfate-process-kinetic-studies-degradation-pathways-and-toxicity-assessments
#13
Xian Lu, Yisheng Shao, Naiyun Gao, Juxiang Chen, Yansen Zhang, Huiming Xiang, Youluo Guo
Diclofenac (DCF) is the frequently detected non-steroidal pharmaceuticals in the aquatic environment. In this study, the degradation of DCF was evaluated by UV-254nm activated persulfate (UV/PS). The degradation of DCF followed the pseudo first-order kinetics pattern. The degradation rate constant (kobs) was accelerated by UV/PS compared to UV alone and PS alone. Increasing the initial PS dosage or solution pH significantly enhanced the degradation efficiency. Presence of various natural water constituents had different effects on DCF degradation, with an enhancement or inhibition in the presence of inorganic anions (HCO3(-) or Cl(-)) and a significant inhibition in the presence of NOM...
March 21, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28340299/bifurcation-of-regeneration-and-recombination-in-dye-sensitized-solar-cells-via-electronic-manipulation-of-tandem-cobalt-redox-shuttles
#14
Josh Baillargeon, Yuling Xie, Thomas W Hamann
A cobalt(IV/III) redox shuttle, cobalt tris(2-(p-tolyl)pyridine), [Co(ptpy)3]+/0, was synthesized and investigated for use in dye-sensitized solar cells, DSSCs. An incredibly fast self-exchange rate constant of (9.2  3.9) × 108 M-1s-1 was determined for [Co(ptpy)3]+/0, making it an ideal candidate for dye regeneration. To avoid fast recombination and solubility limitations, a tandem electrolyte containing [Co(ptpy)3]+/0 and cobalt tris(2,2'-bipyridine), [Co(bpy)3]3+/2+, was utilized. An improved short circuit current density is achieved for DSSCs employing the tandem electrolyte, compared to electrolytes containing only [Co(bpy)3]3+/2+, consistent with superior dye regeneration expected based on predictions using Marcus Theory, which is also discussed...
March 24, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28340294/a-well-defined-osmium-cupin-complex-hyperstable-artificial-osmium-peroxygenase
#15
Nobutaka Fujieda, Takumi Nakano, Yuki Taniguchi, Haruna Ichihashi, Hideki Sugimoto, Yuma Morimoto, Yosuke Nishikawa, Genji Kurisu, Shinobu Itoh
Thermally stable TM1459 cupin superfamily protein from Thermotoga maritima was repurposed as an osmium (Os) peroxygenase by metal-substitution strategy employing the metal-binding promiscuity. This novel artificial metalloenzyme bears a datively bound Os ion supported by the 4-histidine motif. The well-defined Os center is responsible for not only the catalytic activity but also the thermodynamic stability of the protein folding, leading to the robust biocatalyst (Tm ≈ 120 °C). The spectroscopic analysis and atomic resolution X-ray crystal structures of Os-bound TM1459 revealed two types of donor sets to Os center with octahedral coordination geometry...
March 24, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28340267/digital-phenotyping-for-quantification-of-genetic-diversity-in-inbred-guava-psidium-guajava-families
#16
W Krause, A P Viana, N R Cavalcante, M Ambrósio, E A Santos, H D Vieira
Digital image analysis of seeds has been used for the identification of cultivars, determination of seed color and mechanical damage, and classification of different seed sizes. The aim of the present study was to evaluate the efficiency of digital image analysis of seeds for the quantification of genetic diversity among genotypes of inbred guava (Psidium guajava L.) families. The SAS Mini equipment, which consists of a capture module and a software program for analysis, was employed for the capture and analysis of the seed images...
March 22, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28340164/denervation-of-the-extrinsic-cardiac-sympathetic-nervous-system-as-a-treatment-modality-for-arrhythmia
#17
Chance M Witt, Luciana Bolona, Michelle O Kinney, Christopher Moir, Michael J Ackerman, Suraj Kapa, Samuel J Asirvatham, Christopher J McLeod
Denervation of the extrinsic cardiac sympathetic nervous system is a method of altering the autonomic tone experienced by the heart and vasculature. It has been studied and employed as a therapy for cardiac disease for decades. Currently, there is a high level of interest in using cardiac denervation for treatment of arrhythmias. This review describes the anatomy and physiology of the cardiac autonomic nervous system followed by a discussion of the mechanistic studies which provide a basis for the therapeutic use of sympathetic denervation...
March 10, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28340135/modeling-longitudinal-data-and-its-impact-on-survival-in-observational-nephrology-studies-tools-and-considerations
#18
Elani Streja, Leanne Goldstein, Melissa Soohoo, Yoshitsugu Obi, Kamyar Kalantar-Zadeh, Connie M Rhee
Nephrologists and kidney disease researchers are often interested in monitoring how patients' clinical and laboratory measures change over time, what factors may impact these changes, and how these changes may lead to differences in morbidity, mortality, and other outcomes. When longitudinal data with repeated measures over time in the same patients are available, there are a number of analytical approaches that could be employed to describe the trends and changes in these measures, and to explore the associations of these changes with outcomes...
March 3, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28340051/protective-factors-for-work-ability-in-preschool-teachers
#19
I Sottimano, S Viotti, G Guidetti, D Converso
Background: Work ability (WA) describes the physical and intellectual resources on which individuals can rely to respond to work demands. While several studies have investigated the protective role of work-related psychosocial factors on WA, only a few have examined differences across age cohorts. Moreover, few studies have investigated WA in the educational context and most of those did not consider preschool teachers. Aims: To examine the role of psychosocial factors (support from colleagues, support from supervisors, work meaning, reward, skill discretion and autonomy) in sustaining WA among preschool teachers in different age cohorts...
March 8, 2017: Occupational Medicine
https://www.readbyqxmd.com/read/28339985/effects-of-dietary-rapeseed-meal-supplementation-on-cecal-microbiota-in-laying-hens-with-different-flavin-containing-monooxygenase-3-genotypes
#20
C Long, J Wang, H J Zhang, S G Wu, G H Qi
To evaluate the effect of dietary rapeseed meal (RM) supplementation on cecal trimethylamine and bacteria in laying hens with different flavin-containing monooxygenase 3 (FMO3) genotypes, a 3 × 2 2-factorial arrangement was employed using FMO3 genotypes (AA, AT, and TT) and dietary RM (0 and 14% of diet) as the main effects. At 50 wk of age, 36 hens of AT genotype and 36 hens of TT genotype were randomly allotted to one of the 2 dietary treatments, and each dietary treatment consisted of 3 replicates with 6 birds each...
March 4, 2017: Poultry Science
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