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https://www.readbyqxmd.com/read/28441785/evaluation-of-cytotoxic-and-genotoxic-effects-of-euphorbia-triaculeata-forssk-extract
#1
Zarraq I A Al-Faifi, Yahya S Masrahi, Magdy Sayed Aly, Turki A Al-Turki, Tarek Dardeer
Objective: To evaluate the cytotoxic and genotoxic activity of Euphorbia triaculeata Forssk. plant extract from Jazan region, Saudi Arabia, in an in vitro cancer model, which could be beneficial in anticancer therapy against human breast cancer cell line (MCF-7), prostate cell line (PC-3), human hepatocellular carcinoma cell line (HEPG2) and normal breast epithelial cell line (MCF-10A). The human foreskin fibroblast cell line, (Hs68), was also included in the cell panel. Doxorubicin and 5-Flurouracil, broad-spectrum anticancer drugs, were used as the positive control...
March 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28441773/overview-of-four-functional-classification-systems-commonly-used-in-cerebral-palsy
#2
REVIEW
Andrea Paulson, Jilda Vargus-Adams
Cerebral palsy (CP) is the most common physical disability in childhood. CP comprises a heterogeneous group of disorders that can result in spasticity, dystonia, muscle contractures, weakness and coordination difficulty that ultimately affects the ability to control movements. Traditionally, CP has been classified using a combination of the motor type and the topographical distribution, as well as subjective severity level. Imprecise terms such as these tell very little about what a person is able to do functionally and can impair clear communication between providers...
April 24, 2017: Children
https://www.readbyqxmd.com/read/28441767/inhibitory-effect-of-triterpenoids-from-panax-ginseng-on-coagulation-factor-x
#3
Lingxin Xiong, Zeng Qi, Bingzhen Zheng, Zhuo Li, Fang Wang, Jinping Liu, Pingya Li
Enzymes involved in the coagulation process have received great attention as potential targets for the development of oral anti-coagulants. Among these enzymes, coagulation factor Xa (FXa) has remained the center of attention in the last decade. In this study, 16 ginsenosides and two sapogenins were isolated, identified and quantified. To determine the inhibitory potential on FXa, the chromogenic substrates method was used. The assay suggested that compounds 5, 13 and 18 were mainly responsible for the anti-coagulant effect...
April 24, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28441763/improving-passive-time-reversal-underwater-acoustic-communications-using-subarray-processing
#4
Chengbing He, Lianyou Jing, Rui Xi, Qinyuan Li, Qunfei Zhang
Multichannel receivers are usually employed in high-rate underwater acoustic communication to achieve spatial diversity. In the context of multichannel underwater acoustic communications, passive time reversal (TR) combined with a single-channel adaptive decision feedback equalizer (TR-DFE) is a low-complexity solution to achieve both spatial and temporal focusing. In this paper, we present a novel receiver structure to combine passive time reversal with a low-order multichannel adaptive decision feedback equalizer (TR-MC-DFE) to improve the performance of the conventional TR-DFE...
April 24, 2017: Sensors
https://www.readbyqxmd.com/read/28441751/implementation-issues-of-adaptive-energy-detection-in-heterogeneous-wireless-networks
#5
Iker Sobron, Iñaki Eizmendi, Wallace A Martins, Paulo S R Diniz, Juan Luis Ordiales, Manuel Velez
Spectrum sensing (SS) enables the coexistence of non-coordinated heterogeneous wireless systems operating in the same band. Due to its computational simplicity, energy detection (ED) technique has been widespread employed in SS applications; nonetheless, the conventional ED may be unreliable under environmental impairments, justifying the use of ED-based variants. Assessing ED algorithms from theoretical and simulation viewpoints relies on several assumptions and simplifications which, eventually, lead to conclusions that do not necessarily meet the requirements imposed by real propagation environments...
April 23, 2017: Sensors
https://www.readbyqxmd.com/read/28441728/imaging-of-the-finger-vein-and-blood-flow-for-anti-spoofing-authentication-using-a-laser-and-a-mems-scanner
#6
Jaekwon Lee, Seunghwan Moon, Juhun Lim, Min-Joo Gwak, Jae Gwan Kim, Euiheon Chung, Jong-Hyun Lee
A new authentication method employing a laser and a scanner is proposed to improve image contrast of the finger vein and to extract blood flow pattern for liveness detection. A micromirror reflects a laser beam and performs a uniform raster scan. Transmissive vein images were obtained, and compared with those of an LED. Blood flow patterns were also obtained based on speckle images in perfusion and occlusion. Curvature ratios of the finger vein and blood flow intensities were found to be nearly constant, regardless of the vein size, which validated the high repeatability of this scheme for identity authentication with anti-spoofing...
April 22, 2017: Sensors
https://www.readbyqxmd.com/read/28441639/antecubital-fossa-venous-access-for-right-heart-catheterization
#7
Omar Waheed, Abhinav Sharma, Maninder Singh, Edo Kaluski
With the advance of radial access and ulnar access there has been an increased interest in performing right heart catheterization (RHC) and right-heart based procedures via antecubital venous access. Our purpose is to describe the venous anatomy of the upper extremities, technique, equipment, and cost for employing this approach. Reported also is the international experience based on publications assessing procedural success, complications, fluoroscopy time and radiation dose, access-site compression time, and time to ambulation...
May 2017: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/28441605/biological-effects-and-medical-applications-of-infrared-radiation
#8
Shang-Ru Tsai, Michael R Hamblin
Infrared (IR) radiation is electromagnetic radiation with wavelengths between 760nm and 100,000nm. Low-level light therapy (LLLT) or photobiomodulation (PBM) therapy generally employs light at red and near-infrared wavelengths (600-100nm) to modulate biological activity. Many factors, conditions, and parameters influence the therapeutic effects of IR, including fluence, irradiance, treatment timing and repetition, pulsing, and wavelength. Increasing evidence suggests that IR can carry out photostimulation and photobiomodulation effects particularly benefiting neural stimulation, wound healing, and cancer treatment...
April 13, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28441579/geldanamycin-inspired-compounds-induce-direct-trans-differentiation-of-human-mesenchymal-stem-cells-to-neurons
#9
Srinivas Jogula, Anand Ram Soorneedi, Jagan Gaddam, Srinivas Chamakuri, Girdhar Singh Deora, Ranjith Kumar Indarapu, Murali Krishna Ramgopal, Subhadra Dravida, Prabhat Arya
Inspired from geldanamycin, the synthesis of a new series of 20-membered macrocyclic compounds is developed. The key features in our design are (i) retention of the fragment having the precise chiral functional groups of geldanamycin at C10, C11, C12 and C14, and (ii) replacement of an olefin moiety with the ester group, and the quinoid sub-structure with the triazole ring. The southern fragment needed for the macrocyclic ring formation was obtained from Evans' syn aldol as the key reaction and with the use of D-mannitol as the cheap source of a chiral starting material...
April 18, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28441482/the-value-of-nmr-parameters-and-dft-calculations-for-quantum-information-processing-utilizing-phosphorus-heterocycles
#10
Jessica Boreli Dos Reis Lino, Eduardo P Rocha, Teodorico Castro Ramalho
Quantum computing is the field of science that uses quantum-mechanical phenomena, such as superposition and entanglement, to perform operations on data. The fundamental information unit used in quantum computing is the quantum bit or qubit. It is well-known that quantum computers could theoretically be able to solve problems much more quickly than any classical computers. Currently, the first and still the most successful implementations of quantum information processing (QIP) have been based on nuclear spins in liquids...
April 25, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28441474/dendrimer-modified-mos2-nanoflakes-as-a-platform-for-combinational-gene-silencing-and-photothermal-therapy-of-tumors
#11
Lingdan Kong, Lingxi Xing, Benqing Zhou, Lianfang Du, Xiangyang Shi
Exploitation of novel hybrid nanomaterials for combinational tumor therapy is challenging. In this work, we synthesized dendrimer-modified MoS2 nanoflakes for combinational gene silencing and photothermal therapy (PTT) of cancer cells. Hydrothermally synthesized MoS2 nanoflakes were modified with generation 5 (G5) poly(amidoamine) dendrimers partially functionalized with lipoic acid via disulfide bond. The formed G5-MoS2 nanoflakes display good colloidal stability and superior photothermal conversion efficiency and photothermal stability...
April 25, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28441463/rapidsnps-a-new-computational-pipeline-for-rapidly-identifying-key-genetic-variants-reveals-previously-unidentified-snps-that-are-significantly-associated-with-individual-platelet-responses
#12
Bajuna Rashid Salehe, Chris Ian Jones, Giuseppe Di Fatta, Liam James McGuffin
Advances in omics technologies have led to the discovery of genetic markers, or single nucleotide polymorphisms (SNPs), that are associated with particular diseases or complex traits. Although there have been significant improvements in the approaches used to analyse associations of SNPs with disease, further optimised and rapid techniques are needed to keep up with the rate of SNP discovery, which has exacerbated the 'missing heritability' problem. Here, we have devised a novel, integrated, heuristic-based, hybrid analytical computational pipeline, for rapidly detecting novel or key genetic variants that are associated with diseases or complex traits...
2017: PloS One
https://www.readbyqxmd.com/read/28441392/radiation-effects-on-the-mixed-convection-flow-induced-by-an-inclined-stretching-cylinder-with-non-uniform-heat-source-sink
#13
Tasawar Hayat, Sajid Qayyum, Ahmed Alsaedi, Saleem Asghar
This study investigates the mixed convection flow of Jeffrey liquid by an impermeable inclined stretching cylinder. Thermal radiation and non-uniform heat source/sink are considered. The convective boundary conditions at surface are imposed. Nonlinear expressions of momentum, energy and concentration are transformed into dimensionless systems. Convergent homotopic solutions of the governing systems are worked out by employing homotopic procedure. Impact of physical variables on the velocity, temperature and concentration distributions are sketched and discussed...
2017: PloS One
https://www.readbyqxmd.com/read/28441356/a-simple-cost-effective-sensor-for-detecting-lead-ions-in-water-using-under-potential-deposited-bismuth-sub-layer-with-differential-pulse-voltammetry-dpv
#14
Yifan Dai, Chung Chiun Liu
This research has developed a simple to use, cost effective sensor system for the detection of lead ions in tap water. An under-potential deposited bismuth sub-layer on a thin gold film based electrochemical sensor was designed, manufactured, and evaluated. Differential pulse voltammetry (DPV) measurement technique was employed in this detection. Tap water from the Cleveland, OH, USA regional water district was the test medium. Concentrations of lead ion in the range of 8 × 10(-7) M to 5 × 10(-4) M were evaluated, showing a good sensitivity over this concentration range...
April 25, 2017: Sensors
https://www.readbyqxmd.com/read/28441352/high-throughput-determination-of-sodium-danshensu-in-beagle-dogs-by-the-lcms-ms-method-employing-liquid-liquid-extraction-based-on-96-well-format-plates
#15
Jingjing Jiang, Xin Zhao, Xiuxiu Li, Shengyuan Wu, Shidan Yu, Yuefen Lou, Guorong Fan
Sodium Danshensu (sodium d-(+)-β-(3,4-dihydroxyphenyl) lactate), one of the water-soluble ingredients in Salvia miltiorrhiza, exhibits potent relaxation of the coronary artery and anticoagulation effection. A high-throughput, rapid, and sensitive method combining liquid chromatography with electrospray ionization tandem mass spectrometry to determine the sodium danshensu in beagle dog plasma was developed and validated, using gallic acid as an internal standard (IS). Acidified plasma samples were extracted using 96-well liquid-liquid extraction, and were eluted on a CNW Athena C18 column (3 μm, 2...
April 25, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28441351/probing-temperature-and-ph-dependent-binding-between-quantum-dots-and-bovine-serum-albumin-by-fluorescence-correlation-spectroscopy
#16
Zonghua Wang, Qiyan Zhao, Menghua Cui, Shichao Pang, Jingfang Wang, Ying Liu, Liming Xie
Luminescent quantum dots (QDs) with unique optical properties have potential applications in bio-imaging. The interaction between QDs and bio-molecules is important to the biological effect of QDs in vivo. In this paper, we have employed fluorescence correlation spectroscopy (FCS) to probe the temperature- and pH-dependent interactions between CdSe QDs with carboxyl (QDs-COOH) and bovine serum albumin (BSA) in buffer solutions. The results have shown that microscopic dissociation constant K'D is in the range of (1...
April 25, 2017: Nanomaterials
https://www.readbyqxmd.com/read/28441343/immune-stimulatory-effects-of-althaea-rosea-flower-extracts-through-the-mapk-signaling-pathway-in-raw264-7-cells
#17
Yon-Suk Kim, Eun-Kyung Kim, Weligala Pahalagedara Amila Srilal Nawarathna, Xin Dong, Woen-Bin Shin, Jin-Su Park, Sang-Ho Moon, Pyo-Jam Park
Althaea rosea (Linn.) is a medicinal plant from China and Korea that has been traditionally used to control inflammation, to stop bedwetting and as a mouthwash in cases of bleeding gums. Its flowers are employed medicinally for their emollient, demulcent and diuretic properties, which make them useful in chest complaints. Furthermore, a flower extract decoction is used to improve blood circulation, for the treatment of constipation, dysmenorrhoea, haemorrhages, etc. However, the possible mechanisms of the immune-stimulatory effect remains to be elucidated...
April 25, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28441328/a-gradient-field-pulsed-eddy-current-probe-for-evaluation-of-hidden-material-degradation-in-conductive-structures-based-on-lift-off-invariance
#18
Yong Li, Haoqing Jing, Ilham Mukriz Zainal Abidin, Bei Yan
Coated conductive structures are widely adopted in such engineering fields as aerospace, nuclear energy, etc. The hostile and corrosive environment leaves in-service coated conductive structures vulnerable to Hidden Material Degradation (HMD) occurring under the protection coating. It is highly demanded that HMD can be non-intrusively assessed using non-destructive evaluation techniques. In light of the advantages of Gradient-field Pulsed Eddy Current technique (GPEC) over other non-destructive evaluation methods in corrosion evaluation, in this paper the GPEC probe for quantitative evaluation of HMD is intensively investigated...
April 25, 2017: Sensors
https://www.readbyqxmd.com/read/28441323/gold-nanoplates-for-a-localized-surface-plasmon-resonance-based-boric-acid-sensor
#19
Marlia Morsin, Muhamad Mat Salleh, Akrajas Ali Umar, Mohd Zainizan Sahdan
Localized surface plasmon resonance (LSPR) properties of metallic nanostructures, such as gold, are very sensitive to the dielectric environment of the material, which can simply be adjusted by changing its shape and size through modification of the synthesizing process. Thus, these unique properties are very promising, particularly for the detection of various types of chemicals, for example boric acid which is a non-permitted preservative employed in food preparations. For the sensing material, gold (Au) nanoplates with a variety of shapes, i...
April 25, 2017: Sensors
https://www.readbyqxmd.com/read/28441315/an-overview-of-chronic-spinal-pain-revisiting-diagnostic-categories-and-exploring-an-evolving-role-for-neurostimulation
#20
Ashwini Sharan, Jonathan Riley, Christian Hoelscher
STUDY DESIGN: Topic Overview OBJECTIVE.: To describe the varied etiologies resulting in chronic spinal pain and review the current available evidence for treatments. SUMMARY OF BACKGROUND DATA: Chronic pain conditions, especially those that affect the axial back and radiate to the extremities, affect a large population. This results in pronounced disability and a high socioeconomic burden. Our understanding of the underlying mechanisms for chronic pain is limited...
April 24, 2017: Spine
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