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Liv Reidun Tverelv, Sveinung Wergeland Sørbye, Finn Egil Skjeldestad
OBJECTIVE: The Norwegian Cervical Cancer Screening Programme recommends follow-up of histologically confirmed normal/cervical intraepithelial neoplasia (CIN) 1 with combined cytology and human papillomavirus testing within 6 to 12 months. This study examines adherence to guidelines and subsequent risk for CIN 3+ within this subset of women. MATERIALS AND METHODS: Women aged 25 to 69 years attending the Norwegian Cervical Cancer Screening Programme in Norway's 2 northernmost counties were included...
March 14, 2018: Journal of Lower Genital Tract Disease
Srividya Budithi, Richard Peevor, David Pugh, Emmanouil Papagiannakis, Amanda Durman, Nassera Banu, Aderemi Alalade, Simon Leeson
BACKGROUND: The diagnostic accuracy of colposcopy is poor for detecting precancerous cervical lesions. OBJECTIVES: We assessed the performance of colposcopy for identifying cervical intraepithelial neoplasia grade 2 or worse (CIN2+), before and after including a dynamic spectral imaging (DSI) map that quantifies and maps acetowhitening to assist subsequent biopsy of suspicious lesions. METHODS: Four hundred and twenty-five women were examined at a multi-center setting in Wales, of which 393 women were included in the final analysis...
March 14, 2018: Gynecologic and Obstetric Investigation
Sarah Cotton, Robert E Brown, Elizabeth K Nugent, Sonia C Robazetti, Pamela D Berens, Judith A Smith
OBJECTIVE: To assess the consistency between human papillomavirus (HPV) mRNA testing in women with a history of previous HPV infections diagnosed by HPV DNA assay and the potential effects on follow-up HPV screening. METHODS: This was a quality improvement study that used data from a pathology laboratory software database reviewed from November 2014 to June 2016 to identify female patients aged 30 years or older with greater than one HPV-positive result, including one or more HPV mRNA assay results and one or more documented HPV DNA assay results for comparison...
March 8, 2018: Obstetrics and Gynecology
Radmila Sparić, Dimitrios Papoutsis, Saša Kadija, Radomir Stefanović, Angeliki Antonakou, Lazar Nejković, Vesna Kesić
PURPOSE: To investigate the long-term psychosexual outcomes in women following excisional cervical treatment. MATERIALS AND METHODS: Women with cold-knife conization (CKC) or large loop excision of the transformation zone (LLETZ) treatment were interviewed after a follow-up colposcopy visit. Their demographics, treatment and psychosexual characteristics were recorded. RESULTS: One hundred and forty six women with a mean age of 35.2 ± 5...
March 12, 2018: Journal of Psychosomatic Obstetrics and Gynaecology
Ravit Bassal, Yoav Guilburd, Hagit Shapira, Joseph Azuri, Judith Zandbank, Eduardo Schejter
BACKGROUND: The human papillomavirus (HPV) test has proven to be efficient in triaging women with abnormal Pap findings in women with low cytological atypia, but there is no data about the accuracy for large loop excision of transformation zone in cases of recurrent atypia. OBJECTIVES: To assess the clinical correlation between results of HPV typing and conization histology in women who had recurrent abnormal Pap test results with no colposcopy findings. METHODS: Our retrospective cohort study included 138 women enrolled in the Maccabi Healthcare Services who had consecutive atypical Pap test results for 2 years in which no abnormal colposcopic findings were detected...
March 2018: Israel Medical Association Journal: IMAJ
Nguyen Vu Quoc Huy, Le Minh Tam, Ngo Viet Quynh Tram, Dang Cong Thuan, Truong Quang Vinh, Cao Ngoc Thanh, Linus Chuang
This study aims to determine the diagnostic values of visual inspection with acetic acid (VIA) and Pap smear in a cervical cancer screening program at a community level in Vietnam. A cross-sectional analysis was obtained, including 1034 women of reproductive age from Thua Thien Hue Province, Vietnam from 09/2012 to 09/2013. Samples were taken from cervixes for Pap smear testing, followed by visual inspection with acetic acid. Subjects with abnormal VIA and/or positive cytology results were invited for colposcopy and biopsy...
May 2018: Gynecologic Oncology Reports
Lulu Yu, Mingyue Jiang, Pengpeng Qu, Zeni Wu, Peisong Sun, Mingrong Xi, Yu Qin, Xin Liu, Guangdong Liao, Xiaoqin Lei, Lixin Sun, Yongzhen Zhang, Zhifang Li, Wen Chen, You-Lin Qiao
HPV-16 and -18 account for about 80% of cervical cancers. We evaluated the performance of HPV-16/18 oncoprotein to predict precancer and cancer in corresponding tissue biopsy specimens. 1008 women attending cervical cancer screening program and 638 women referred to colposcopy with biopsy-confirmed cervical intraepithelial neoplasia grade 2 or worse (CIN2+) from 4 hospitals were recruited (1646 in total). All women were tested OncoE6 (AVC), Liquid Based Cytology (Hologic) and cobas HPV test (Roche). Colposcopy was performed on women with any abnormal results...
March 9, 2018: International Journal of Cancer. Journal International du Cancer
Aiping Fan, Chen Wang, Liqin Zhang, Ye Yan, Cha Han, Fengxia Xue
Objective: To evaluate the diagnostic accuracy of the 2011 International Federation for Cervical Pathology and Colposcopy (IFCPC) colposcopic terminology. Methods: The clinicopathological data of 2262 patients who underwent colposcopy from September 2012 to September 2016 were reviewed. The colposcopic findings, colposcopic impression, and cervical histopathology of the patients were analyzed. Correlations between variables were evaluated using cervical histopathology as the gold standard...
February 6, 2018: Oncotarget
Christina Founta, Emmanouil Papagiannakis, Nithya Ratnavelu, Arlene Feusi, Stavros Natsis, Melissa Bradbury, Ann Fisher, Raj Naik
After treatment for cervical intraepithelial neoplasia (CIN), in the UK women who are cytology-negative, high-risk (HR) human papilloma virus (HPV) positive are referred to colposcopy. This pilot study assessed the incidence of residual/recurrent CIN and the diagnostic accuracy of colposcopy with dynamic spectral imaging (DSI) mapping in their detection.This was a prospective service evaluation carried out in a UK National Health Service (NHS) colposcopy clinic. All women, referred with negative cytology/HR-HPV positive result following treatment for CIN from March 2013 until November 2014, who were examined with the DSI digital colposcope were included...
January 2018: Medicine (Baltimore)
H R Wang, Y Lin, X Y Zhang, X T Ma
This study aims to assess the value of transvaginal color Doppler sonography (TVCD) combined with colposcopy for diagnosis of early stage cervical cancer and precancerous lesions. From January 2015 to September 2016, one hundred patients, diagnosed as having early stage cervical cancer and precancerous lesions by histopathological study, were selected as the observation subjects. All patients were examined by TVCD and colposcopy, and the results were compared with histopathological findings. The diagnostic accuracy, sensitivity and specificity of TVCD alone, colposcopy alone, and TVCD combined with colposcopy in early stage of cervical cancer and precancerous lesion were compared...
January 2018: Journal of Biological Regulators and Homeostatic Agents
Ayodele Gomih, Jennifer S Smith, Kari E North, Michael G Hudgens, Wendy R Brewster, Zhiqing Huang, David Skaar, Fidel Valea, Rex C Bentley, Adriana C Vidal, Rachel L Maguire, Randy L Jirtle, Susan K Murphy, Cathrine Hoyo
The role of host epigenetic mechanisms in the natural history of low-grade cervical intraepithelial neoplasia (CIN1) is not well characterized. We explored differential methylation of imprinted gene regulatory regions as predictors of the risk of CIN1 regression. A total of 164 patients with CIN1 were recruited from 10 Duke University clinics for the CIN Cohort Study. Participants had colposcopies at enrollment and up to five follow-up visits over three years. DNA was extracted from exfoliated cervical cells for methylation quantitation at CpG (cytosine-phosphate-guanine) sites and human papillomavirus (HPV) genotyping...
February 28, 2018: International Journal of Cancer. Journal International du Cancer
L Stewart Massad
Cervical cancer prevention guidelines are benchmarked to risk of cervical precancer. In younger age cohorts, vaccination against high-risk types of human papillomavirus (HPV) has reduced HPV 16/18 prevalence and cervical intraepithelial neoplasia. Lower prevalence of precancer will impair the sensitivity of cytology and colposcopy, but negative predictive value will rise. Training and skills maintenance will become more difficult as abnormalities become less common. Primary screening with HPV assays will become more attractive but will require HPV genotyping as most positive HPV tests will reflect non-16/18 infections with lower oncogenicity...
February 23, 2018: Journal of Lower Genital Tract Disease
Laura R Daily, Britt K Erickson, Daniel N Pasko, J Michael Straughn, Warner K Huh, Charles A Leath
OBJECTIVE: The aim of the study was to determine rates of cervical intraepithelial neoplasia (CIN) 2 or greater in high-risk, racially diverse, young women with low-grade cytology. MATERIALS AND METHODS: After institutional review board approval, a cross-sectional study of 21- to 24-year-old women with low-grade cytology (atypical squamous cells of undetermined significance, high-risk human papillomavirus+, low-grade squamous intraepithelial lesion, or human papillomavirus+ only) managed with colposcopy at our university-based clinic between May 2011 and April 2013 were identified...
February 23, 2018: Journal of Lower Genital Tract Disease
Emmanouil Kalampokas, Judith Wilson, Mahalakshmi Gurumurthy, Margaret E Cruickshank
OBJECTIVE: In United Kingdom., test of cure after treatment of any grade of cervical intraepithelial neoplasia (CIN) incorporates high-risk human papillomavirus (Hr-HPV) test and cytology at 6-month follow-up. The aims of the study were to determine the rate of recurrent CIN in women who are Hr-HPV positive and cytology negative and to explore possible associated risk factors. METHODS: A retrospective observational cohort study was performed in women treated for any grade CIN between 2010 and 2015 from a regional population, who were Hr-HPV positive and cytology negative at first follow-up...
February 23, 2018: Journal of Lower Genital Tract Disease
Liat Binyamin, Meirav Segev, Yoav Peled, Haim Krissi, Gad Sabah, Oded Raban, Ariella Jakobson-Setton, Avi Ben-Haroush, Ram Eitan
OBJECTIVE: Many patients undergo hysterectomy for the treatment of cervical dysplasia. Factors that correlate with residual high-grade squamous intraepithelial lesions (HGSIL) at hysterectomy are not clear. We set out to determine preoperative features that may predict residual disease for patients treated for cervical dysplasia. MATERIALS AND METHODS: A retrospective database was reviewed for women who underwent simple hysterectomy for HGSIL between 1990 and 2013...
February 23, 2018: Journal of Lower Genital Tract Disease
Dorothy L Patton, Yvonne C Sweeney, Audrey E Baldessari, Linda Cles, Laszlo Kari, Gail L Sturdevant, Chunfu Yang, Harlan D Caldwell
The Chlamydia trachomatis plasmid and inclusion membrane protein CT135 are virulence factors in the pathogenesis of murine female genital tract infection. To determine if these virulence factors play a similar role in female non-human primates, we infected pig-tailed macaques with the same C. trachomatis strains shown to be important in the murine model. Wild type C. trachomatis and its isogenic mutant strain deficient in both plasmid and CT135 were used to infect macaques. Macaques were given primary and repeated cervicovaginal challenges with the wild type and mutant strains...
February 20, 2018: Infection and Immunity
Nicolas Wentzensen, Joan Walker, Katie Smith, Michael A Gold, Rosemary Zuna, L Stewart Massad, Angela Liu, Michelle I Silver, S Terence Dunn, Mark Schiffman
OBJECTIVE: Sensitivity for detection of precancers at colposcopy and reassurance provided by a negative colposcopy are in need of systematic study and improvement. We sought to evaluate whether selecting the appropriate women for multiple targeted cervical biopsies based on screening cytology, HPV testing, and colposcopic impression could improve accuracy and efficiency of cervical precancer detection. METHODS: 690 women aged 18-67 referred to colposcopy subsequent to abnormal cervical cancer screening results were included in the study (ClinicalTrials...
February 17, 2018: American Journal of Obstetrics and Gynecology
İbrahim Karaca, Mustafa Öztürk, Cihan Comba, Gökhan Demirayak, İsmail Alay, Volkan Şakir Erdoğan, Murat Hoşgören, Levent Yaşar
BACKGROUND: According to the American Society of Colposcopy and Cervical Pathology (ASCCP), a co-test is recommended for patients one year after the detection of non-HPV 16/18 viral types in association with a negative cervical cytology. In this study, we used immediate colposcopy to evaluate the risks to the patient during the one year waiting period. METHODS: We included 544 Hpv-positive/cervical cytology-negative patients who underwent cervical cancer screening from June 2015 to June 2017...
February 19, 2018: Diagnostic Cytopathology
Natacha Phoolcharoen, Nuttavut Kantathavorn, Wasanai Krisorakun, Thaniya Sricharunrat, Narongchai Teerayathanakul, Chantanee Taepisitpong, Gaidganok Sornsamdang, Waraphorn Krongthong, Siriporn Saeloo
OBJECTIVE: To study the concordance between vaginal self- and endocervical physician-collected high-risk (hr) HPV testing in Thai women who attended a colposcopy clinic. Vaginal samples were obtained by self-sampling with a dry brush before endocervical samples were obtained by physicians. Both specimens were analyzed for hrHPV by Cobas4800 HPV test. RESULTS: Of the 247 pairs of samples, overall hrHPV prevalence from self- and physician-collected samples was 41...
February 20, 2018: BMC Research Notes
Masakazu Sato, Koji Horie, Aki Hara, Yuichiro Miyamoto, Kazuko Kurihara, Kensuke Tomio, Harushige Yokota
The objective of the present study was to investigate whether deep learning could be applied successfully to the classification of images from colposcopy. For this purpose, a total of 158 patients who underwent conization were enrolled, and medical records and data from the gynecological oncology database were retrospectively reviewed. Deep learning was performed with the Keras neural network and TensorFlow libraries. Using preoperative images from colposcopy as the input data and deep learning technology, the patients were classified into three groups [severe dysplasia, carcinoma in situ (CIS) and invasive cancer (IC)]...
March 2018: Oncology Letters
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