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https://www.readbyqxmd.com/read/28926579/cervical-screening-with-primary-hpv-testing-or-cytology-in-a-population-of-women-in-which-those-aged-33-years-or-younger-had-previously-been-offered-hpv-vaccination-results-of-the-compass-pilot-randomised-trial
#1
Karen Canfell, Michael Caruana, Val Gebski, Jessica Darlington-Brown, Stella Heley, Julia Brotherton, Dorota Gertig, Chloe J Jennett, Annabelle Farnsworth, Jeffrey Tan, C David Wrede, Philip E Castle, Marion Saville
BACKGROUND: Using primary human papillomavirus (HPV) testing for cervical screening increases detection of high-grade cervical intraepithelial neoplastic lesions and invasive cancer (cervical intraepithelial neoplasia grade 2+ [CIN2+]) compared to cytology, but no evaluation has been conducted in a population previously offered HPV vaccination. We aimed to assess colposcopy referral and CIN2+ detection rates for HPV-screened versus cytology-screened women in Australia's HPV-vaccinated population (by 2014, resident women ≤33 years had been age-eligible for HPV vaccination, with 3-dose uptake across age cohorts being about 50%-77%)...
September 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28919616/detection-of-human-papilloma-virus-by-molecular-method-from-patients-attending-at-colposcopy-clinic-of-mymensingh-medical-college-hospital-mymensingh
#2
H Begum, M A Hossain, S K Paul, S A Nasreen, S Ahmed, S Nahar, S Monwar, F Nahar, S Roy, S A Abdullah, S Abedin, M U Ahmed, T K Barman
Cervical cancer is the second most common cancer in women worldwide. Human papillomavirus (HPV) is considered as the main cause of invasive cervical cancer and cervical intra-epithelial neoplasia. High risk HPV DNA has been shown to be present in 99.7% of cervical cancers. So HPV DNA testing for screening of cervical cancers may play a potential role in early detection and management of cervical cancer. With above background a cross sectional study was undertaken to estimate the prevalence and to identify the associated risk factors of human Papillomavirus infection among Visual Inspection with Acetic acid (VIA) positive women attending at colposcopy clinic of Mymensingh Medical College Hospital (MMCH), Mymensingh, Bangladesh from July 2013 to December 2014...
July 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/28919602/comparative-study-of-cytology-and-histopathology-of-cervical-lesion-in-via-positive-patients-and-its-correlation-with-high-risk-human-papilloma-virus
#3
N P Ansari, F M Saleh, S M Shahida, E N Rahman
Cervical cancer is the second most frequent type of cancer and leading cause of mortality among women worldwide. The present study was undertaken to assess precancerous and cancerous cervical lesion by cytology as well as HPV DNA identification and their comparison with histopathology in VIA positive cases. This descriptive, cross-sectional type of observational study was carried out in the Department of Pathology, Mymensingh Medical College in collaboration with the Department of Gynecology and Obstetrics, Mymensingh Medical College Hospital and Department of Microbiology and Hygiene in Bangladesh Agriculture University for HPV DNA detection from July 2012 to June 2013...
July 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/28916509/risk-prediction-of-cervical-cancer-and-precancers-by-type-specific-human-papillomavirus-%C3%A2-evidence-from-a-population-based-cohort-study-in-china
#4
Li Dong, Shang-Ying Hu, Qian Zhang, Ruimei Feng, Li Zhang, Xuelian Zhao, Xun Zhang, Fang-Hui Zhao, You-Lin Qiao
Risk stratification of human papillomavirus (HPV)-positive women is needed to avoid excessive colposcopy and overtreatment in cervical cancer screening. We aimed to evaluate the predictive value of type-specific HPV in detecting cervical cancer and precancers in a Chinese population-based cohort and provide evidence of HPV genotyping to triage HPV-positive women. We typed all Hybrid Capture 2-positive cytological samples of 1,742 women in Shanxi Province Cervical Cancer Screening Study cohort. Cumulative risks of cervical intraepithelial neoplasia grade 2 or worse (CIN2+) among HPV positive women and cumulative detection rates of CIN2+ among general women by type-specific HPV were estimated during the course of ten-year follow-up...
September 15, 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/28901302/the-clinical-application-of-hpv-e6-e7-mrna-testing-in-triaging-women-with-atypical-squamous-cells-of-undetermined-significance-or-low-grade-squamous-intra-epithelial-lesion-pap-smear-a-meta-analysis
#5
REVIEW
Li Yang, Yuanhang Zhu, Yang Bai, Xiaoan Zhang, Chenchen Ren
OBJECTIVE: The aim is to evaluate the clinical application value and correlation with cervical lesions' progression of human papillomavirus (HPV) E6/E7 mRNA test in women with atypical squamous cells of undetermined significance (ASCUS/borderline) or low-grade squamous intraepithelial lesions (LSILs/mild dyskaryosis) cytological abnormalities. METHODS: A meta-analysis was conduct by searching China National Knowledge Infrastructure (1979-2016), Wanfang Date (1998-2016), VIP (1989-2016), PubMed (1950-2016), Web of Science (1950-2016) and Elsevier Science Direct (1998-2016), for studies on effect of HPV E6/E7 mRNA detection in women with ASCUS/LSIL/dyskaryosis...
2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28890676/the-effect-of-music-in-gynaecological-office-procedures-on-pain-anxiety-and-satisfaction-a-randomized-controlled-trial
#6
N Mak, I M A Reinders, S A Slockers, E H M N Westen, J W M Maas, M Y Bongers
BACKGROUND: Pain can interfere with office procedures in gynaecology. The aim of this study is to measure the positive effect of music in gynaecological office procedures. METHODS: A randomized controlled trial was performed between October 2014 and January 2016. Women scheduled for an office hysteroscopy or colposcopy were eligible for randomization in the music group or control group. Stratification for hysteroscopy and colposcopy took place. The primary outcome is patients' level of pain during the procedure measured by the visual analogue scale (VAS)...
2017: Gynecological Surgery
https://www.readbyqxmd.com/read/28887297/defining-optimal-triage-strategies-for-hrhpv-screen-positive-women-an-evaluation-of-hpv-16-18-genotyping-cytology-and-p16-ki-67-cyto-immunochemistry
#7
Grazyna A Stanczuk, Gwen J Baxter, Heather Currie, William Forson, James R Lawrence, Kate Cuschieri, Allan Wilson, Lynne Patterson, Lynn Govan, Janice Black, Tim Palmer, Marc Arbyn
BACKGROUND: Several options for the triage of high-risk HPV screen positive (hrHPV+) women were assessed. METHODS: This study incorporated CIN2+ cases and controls, all of whom tested hrHPV+ and whose results of liquid-based cytology (LBC), HPV16/18 genotyping and p16/Ki67 cyto-immunochemistry were available. Sensitivity and specificity for the CIN2+ of these triage tests were evaluated. RESULTS: Absolute sensitivities of HPV 16/18 typing, LBC and p16/Ki-67 cyto-immunochemistry for CIN2+ detection were 61...
September 8, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28885082/human-papillomavirus-testing-by-veterans-administration-women-s-health-providers-are-they-adhering-to-guidelines
#8
Laura D Hallett, Megan R Gerber
BACKGROUND: Evidence-based guidelines have been created by professional societies, including the United States Preventive Services Task Force (USPSTF) and American Society for Colposcopy and Cervical Pathology (ASCCP), for use of human papillomavirus (HPV) cotesting in cervical cancer screening. We investigated whether Veterans Health Administration (VA) providers at one VA medical center follow these guidelines. MATERIALS AND METHODS: Retrospective chart review of women aged 21-65 who had an HPV test ordered with pap testing in fiscal year 2014 at one Veterans Administration (VA) medical center to evaluate concordance of HPV ordering with screening (USPSTF) and management (ASCCP) guidelines...
September 8, 2017: Journal of Women's Health
https://www.readbyqxmd.com/read/28866125/the-impact-of-using-electrical-impedance-spectroscopy-zedscan-on-the-performance-of-colposcopy-in-diagnosing-high-grade-squamous-lesions-of-the-cervix
#9
C Muszynski, E Dupont, B Vaysse, S Lanta, J Tidy, F Sergent, J Gondry
OBJECTIVES: To determine the efficacy of colposcopy plus ZedScan, which measures changes in tissue electrical impedance, for detecting intraepithelial high-grade lesions compared to colposcopy alone. METHODS: A prospective study conducted at a university hospital colposcopy clinic. Patients referred following abnormal cervical cytology or colposcopic follow up were examined by colposcopy plus ZedScan to assess the cervix. The results of ZedScan directed and colposcopically directed biopsies were compared...
September 1, 2017: Journal of gynecology obstetrics and human reproduction
https://www.readbyqxmd.com/read/28843222/accuracy-of-cervical-visual-inspection-with-acetic-acid-guide-for-4-quadrant-random-cervical-biopsies-by-general-practitioners-in-women-with-abnormal-pap-smears
#10
Patrada Suwansura, Darigar Darojn
Objective: To study the performance of visual inspection with acetic acid plus 4-quadrant cervical biopsy (V4B) by general practitioners in detecting high grade cervical lesion, compared to highest histopathologic grade from the American Society for Colposcopy and Cervical Pathology American Society for Colposcopy and Cervical Pathology (ASCCP) 2013 work up guidelines. Materials and methods: Patients with abnormal cervical cytologic screening results suggesting low grade lesions underwent V4B by general practitioners followed by colposcopy on the same day bases on ASCCP 2013 guidelines...
August 27, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28830493/unsatisfactory-colposcopy-clinical-decision-making-in-conditions-of-uncertainty
#11
Kristyn M Manley, Rebecca A Simms, Sarah Platt, Amit Patel, Rachna Bahl
BACKGROUND: Unsatisfactory colposcopy, where the cells of interest are not visible in women with a positive cervical screening test, is a common area of clinical uncertainty due to the lack of clear evidence and guidance. Colposcopists' opinions and experiences are likely to have a significant influence on service provision and the development of national policy. The aim of this study was to analyse decision-making when applied to women with unsatisfactory colposcopy. METHODS: A multi-centre qualitative study utilizing a series of focus groups in an English healthcare region...
August 22, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/28821890/detection-rate-of-high-grade-cervical-neoplasia-and-cost-effectiveness-of-high-risk-human-papillomavirus-genotyping-with-reflex-liquid-based-cytology-in-cervical-cancer-screening
#12
Sun Kuie Tay, Lynette Eo Lin, Ronald Ch Goh
INTRODUCTION: This study aimed to determine the prevalence of cervical intraepithelial neoplasia grade 3 or worse (≥CIN3) and cost-effectiveness of human papillomavirus (HPV) genotyping with reflex liquid-based cytology (LBC) for cervical cancer screening in Singapore. MATERIALS AND METHODS: Women who were ≥25 years old and undertook co-testing with LBC and HPV-genotyping (Cobas-4800, Roche, USA) for HPV-16, HPV-18 and 12 high-risk HPV types in a single institution were studied retrospectively...
July 2017: Annals of the Academy of Medicine, Singapore
https://www.readbyqxmd.com/read/28820421/-the-role-of-papillomavirus-infection-in-the-development-of-background-disease-of-the-cervix
#13
S Muslimova
Papillomavirus infection is one of the most common sexually transmitted infections. The aim of the study was to study the etiologic significance of the papillomavirus infection in the development of background diseases of the cervix and neoplasia. Under observation were 62 patients aged 18 to 55 years infected with human papillomavirus. All patients underwent complex clinical and anamnestic, laboratory and instrumental examination. Also, a review and advanced colposcopy was performed. As a result of the study, 53 (85...
July 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28819938/see-and-treat-strategy-by-leep-conization-in-patients-with-abnormal-cervical-cytology
#14
Fuat Demirkiran, Ilker Kahramanoglu, Hasan Turan, Nevin Yilmaz, Aslihan Yurtkal, Elif Meseci, Tugan Bese, Sennur Ilvan, Macit Arvas
OBJECTIVES: To determine the overtreatment and re-LEEP rates of see and treat strategy (S & T) in women who underwent S & T by LEEP and to identify the risk factors for overtreatment and surgical margin and/or endocervical curettage positivity. MATERIAL AND METHODS: A total of 800 patients who underwent S & T in Istanbul University Cerrahpasa Medical Faculty between June 2010 and June 2016 were retrospectively analyzed. RESULTS: Overtreatment rate was found to be 46...
2017: Ginekologia Polska
https://www.readbyqxmd.com/read/28797154/-to-analyse-the-histopathological-results-of-patients-with-hpv16-18-positive-and-colposcopic-suspicious-lesions
#15
J X Zhang, T P Zheng, J Liu, Q X Wang, Y X Zhan, Z Y Zhang
Objective: To explore the value of histopathologic diagnosis after colposcopy for high-risk HPV16/18 positive patients with negative cytology or atypical squamous cells of undetermined significance (ASCUS) for early screening of cervical lesions. Methods: A retrospective study of cervical histopathologic diagnosis in the HPV16/18 positive patients received colposcopy evaluation before got the histology was carried out between January 2014 and January 2016. The cytology of the patients should be negative or ASCUS...
July 25, 2017: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/28791267/atypical-squamous-cells-of-undetermined-significance-and-low-grade-squamous-intraepithelial-lesion-triage-in-korean-women-revisiting-the-2012-american-society-of-colposcopy-and-cervical-pathology-screening-guidelines
#16
Ji Yeon Hyun, Kyung-Jin Min, Sun Young Yang, Jae-Kwan Lee, Jin Hwa Hong
OBJECTIVE: To determine whether triage for atypical squamous cells of undetermined significance (ASC-US) and low-grade squamous intraepithelial lesion (LSIL) from the updated American Society for Colposcopy and Cervical Pathology cervical cancer screening guidelines is applicable in Korean women. METHODS: We investigated women with ASC-US or LSIL including referred from local hospitals visited for cervical cancer screening at Korea University Guro Hospital from February 2004 to December 2014...
July 2017: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/28790867/cervical-cancer-screening-in-low-resource-settings-a-smartphone-image-application-as-an-alternative-to-colposcopy
#17
Caroline Gallay, Anne Girardet, Manuela Viviano, Rosa Catarino, Anne-Caroline Benski, Phuong Lien Tran, Christophe Ecabert, Jean-Philippe Thiran, Pierre Vassilakos, Patrick Petignat
BACKGROUND: Visual inspection after application of acetic acid (VIA) and Lugol's iodine (VILI) is a cervical cancer (CC) screening approach that has recently been adopted in low- and middle-income countries (LMIC). Innovative technologies allow the acquisition of consecutive cervical images of VIA and VILI using a smartphone application. The aim of this study was to evaluate the quality of smartphone images in order to assess the feasibility and usability of a mobile application for CC screening in LMIC...
2017: International Journal of Women's Health
https://www.readbyqxmd.com/read/28777141/cytologic-histologic-discrepancies-in-pathology-of-the-uterine-cervix-analysis-of-the-clinical-and-pathologic-factors
#18
Fadi W Abdul-Karim, Bin Yang
Cytologic-histologic correlation (CHC) represents a documented effort to obtain and compare, when available, gynecologic cytology reports with an interpretation of high-grade squamous intraepithelial lesion or malignancy, with the subsequent histopathology report, and to determine the possible cause of any discrepancy. The correlation is influenced by multiple closely interdependent clinical and pathologic factors. Many of these factors including the sensitivity and accuracy of colposcopy-directed biopsy, the diligence of the colposcopist, and the attributes of the cervical lesion represent "preanalytical" factors which can significantly affect the CHC outcome, but are often less emphasized during CHC process...
September 2017: Advances in Anatomic Pathology
https://www.readbyqxmd.com/read/28772279/choosing-wisely-a-model-based-analysis-evaluating-the-trade-offs-in-cancer-benefit-and-diagnostic-referrals-among-alternative-hpv-testing-strategies-in-norway
#19
Emily A Burger, Kine Pedersen, Stephen Sy, Ivar Sønbø Kristiansen, Jane J Kim
BACKGROUND: Forthcoming cervical cancer screening strategies involving human papillomavirus (HPV) testing for women not vaccinated against HPV infections may increase colposcopy referral rates. We quantified health and resource trade-offs associated with alternative HPV-based algorithms to inform decision-makers when choosing between candidate algorithms. METHODS: We used a mathematical simulation model of HPV-induced cervical carcinogenesis in Norway. We compared the current cytology-based strategy to alternative strategies that varied by the switching age to primary HPV testing (ages 25-34 years), the routine screening frequency (every 3-10 years), and management of HPV-positive, cytology-negative women...
September 5, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28763729/an-evaluation-of-clinical-performance-of-fta-cards-for-hpv-16-18-detection-using-cobas-4800-hpv-test-compared-to-dry-swab-and-liquid-medium
#20
Li Dong, Chunqing Lin, Li Li, Margaret Wang, Jianfeng Cui, Ruimei Feng, Bin Liu, Zeni Wu, Jia Lian, Guangdong Liao, Wen Chen, Youlin Qiao
BACKGROUNDS: Effective dry storage and transport media as an alternative to conventional liquid-based medium would facilitate the accessibility of women in the low-resource settings to human papillomavirus (HPV)- based cervical cancer screening. OBJECTIVE: To evaluate analytical and clinical performance of indicating FTA™ Elute Cartridge (FTA card) for the detection of HPV16/18 and cervical precancerous lesions and cancer compared to dry swab and liquid medium...
June 29, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
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