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https://www.readbyqxmd.com/read/28431558/epidemiology-and-genotype-distribution-of-human-papillomavirus-hpv-in-southwest-china-a-cross-sectional-five-years-study-in-non-vaccinated-women
#1
Yishu Tang, Lan Zheng, Shuangshuang Yang, Bing Li, Huiting Su, Li-Ping Zhang
BACKGROUND: Large-size data on type-specific HPV prevalence in Southwest China are required to estimate the cervical cancer burden in the country and to prepare for HPV-based cervical screening program and further HPV vaccination of China. This HPV study is a pooled analysis of data from five years in Chongqing of China, which is cross-sectional in design using data collecting. RESULTS: The positivity of HPV was 26.2% (10542/40311), single type was 25.7% (10360/40311), multiple type was 8...
April 21, 2017: Virology Journal
https://www.readbyqxmd.com/read/28427086/self-sampling-to-improve-cervical-cancer-screening-coverage-in-switzerland-a-randomised-controlled-trial
#2
Manuela Viviano, Rosa Catarino, Emilien Jeannot, Michel Boulvain, Manuela Undurraga Malinverno, Pierre Vassilakos, Patrick Petignat
BACKGROUND: The aim of this study is to evaluate whether self-sampling can increase screening attendance of women who do not attend regular screening in Switzerland. METHODS: Participants were proactively recruited in Geneva between September 2011 and November 2015. Women (25-69 years) who had not undergone CC screening in the last 3 years were considered eligible. Through a 1 : 1 ratio randomisation, enrolled participants were invited to either undergo liquid-based cytology, which was performed by a health-care provider (control group, CG) or to take a self-sample for HPV-testing, which was mailed to their home (intervention group, IG)...
April 20, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28409592/repeat-cytology-within-six-months-equals-colposcopy-for-younger-women-with-ascus-or-lsil
#3
Linda M Speer
No abstract text is available yet for this article.
April 1, 2017: American Family Physician
https://www.readbyqxmd.com/read/28404931/a-retrospective-analysis-of-the-utility-of-endocervical-curettage-in-screening-population
#4
Yan Song, Yu-Qian Zhao, Ling Li, Qin-Jin Pan, Nan Li, Fang-Hui Zhao, Wen Chen, Xun Zhang, You-Lin Qiao
The performance of endocervical curettage (ECC) is a dispute in population screening programs. Data of 3,460 women referred to colposcopy examination and had completed pathological results in the Shanxi Province Cervical Cancer Screening Study I and II were reviewed. Among them, 0.6% and 2.7% women were identified as the histopathological confirmed high-grade squamous intraepithelial lesion or worse (HSIL+) by ECC alone or both ECC and quadrants biopsy respectively. Age, cytology, and colposcopy impression are the impact factors for the HSIL+ yield of ECC (P<0...
February 23, 2017: Oncotarget
https://www.readbyqxmd.com/read/28403967/organization-and-first-results-of-cervical-cancer-screening-program-in-mayotte-from-2010-to-2014
#5
Z Stewart, E Garcin, A Nazac, C Mezan de Malartic, C Georges, A Cimmino
OBJECTIVES: Our main goal was to report the organization of individual screening for uterus cancer in Mayotte, the last French department since 2011, and its first results. MATERIAL AND METHODS: Epidemiological and observational study describing the prior situation, the beginning of the screening with pap smears in 2010, the colposcopy consultations and the treatment of the patients by the Mayotte network for screening of cancers since 2010. RESULTS: The screening allowed an improvement of the global cover rate from 5% to 24% in 5 years...
February 2017: J Gynecol Obstet Hum Reprod
https://www.readbyqxmd.com/read/28403024/multimodal-hyperspectroscopic-imaging-for-detection-of-high-grade-cervical-intraepithelial-neoplasia
#6
Renée M F Ebisch, Marjolein Hermens, Petronella A J van den Akker, Leon F A G Massuger, Willem J G Melchers, Ruud L M Bekkers
OBJECTIVE: Numerous new alternative digital colposcopy techniques have been developed, of which multimodal hyperspectroscopy (MHS) showed a high sensitivity in previous studies. The objective of this prospective single-center cohort study was to evaluate the clinical value of MHS for detecting high-grade cervical intraepithelial neoplasia in a colposcopy referral population and colposcopy follow-up population, to assess whether MHS could be safely used to improve care for women at risk for high-grade cervical intraepithelial neoplasia...
April 11, 2017: Journal of Lower Genital Tract Disease
https://www.readbyqxmd.com/read/28397203/comparison-of-the-diagnostic-value-of-cervical-cytology-and-hpv-hr-dna-testing-for-the-diagnosis-of-low-grade-and-high-grade-squamous-intraepithelial-lesions-across-different-age-groups
#7
Aleksandra Paluszkiewicz, Dominik Pruski, Kinga Iwaniec, Witold Kędzia
OBJECTIVES: To assess the diagnostic value of cervical cytology and HPV HR DNA testing for the diagnosis of low grade and high-grade squamous intraepithelial lesions across different age groups. MATERIAL AND METHODS: The study included 1103 patients, age 25-70 years. All patients underwent in-depth diagnostic tests following either an abnormal Pap test result or a clinically suspicious cervical lesion. In all women the following examinations were performed: a molecular test detecting 14 high-risk types of HPV, a colposcopy examination, as well as directed-biopsy of the cervix...
2017: Ginekologia Polska
https://www.readbyqxmd.com/read/28392582/does-cin2-have-the-same-aggressive-potential-as-cin3-a-secondary-analysis-of-high-grade-cytology-recurrence-in-women-treated-with-cold-coagulation-cervical-treatment
#8
D Papoutsis, M Underwood, W Parry-Smith, J Panikkar
Introduction To determine whether women with CIN2 versus CIN3 on pretreatment cervical punch biopsy have less high-grade cytology recurrence following cold-coagulation cervical treatment. Materials and Methods This was a retrospective study of women having had cold coagulation between 2001-2011 in our colposcopy unit. Women with previous cervical treatment were excluded. Results We identified 402 women with 260 (64.7 %) cases of CIN2 and 142 (35.3 %) cases of CIN3 on pretreatment cervical punch biopsy. In the total sample, the mean age of women was 27...
March 2017: Geburtshilfe und Frauenheilkunde
https://www.readbyqxmd.com/read/28391626/urinary-hpv-testing-may-offer-hope-for-cervical-screening-non-attenders
#9
Dominic A Blake, Emma J Crosbie, Sarah Kitson
Despite the success of cervical screening, cancer of the cervix is the fourth most common cancer affecting women worldwide (CRUK 2014). Rates are particularly high in developing nations, which lack the requisite infrastructure for cytology and colposcopy-based screening, and in certain demographic groups, where uptake of screening is poor. Recent research has focussed on developing less invasive and potentially more acceptable means of identifying women at high risk of cervical intraepithelial neoplasia (CIN)...
April 9, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28391609/hpv-testing-in-first-void-urine-provides-sensitivity-for-cin2-detection-comparable-to-a-physician-taken-smear-or-brush-based-self-sample-cross-sectional-data-from-a-triage-population
#10
Annemiek Leeman, Marta Del Pino, Anco Molijn, Agata Rodriguez, Aureli Torné, Maurits de Koning, Jaume Ordi, Folkert van Kemenade, David Jenkins, Wim Quint
OBJECTIVES: To compare sensitivity of high-risk HPV (hrHPV) and genotype detection in self-collected morning (U1) and later (U2) urine samples, brush-based self-samples (SS) and physician-taken smears (PTS) for detecting CIN2+ in a colposcopic referral population. DESIGN: Cross-sectional single centre study. SETTING: A colposcopy clinic in Spain. POPULATION: 113 women referred for colposcopy after an abnormal Pap-smear...
April 9, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28388819/retrospective-study-of-the-influence-of-hpv-persistence-on-outcomes-among-women-with-high-risk-hpv-infections-and-negative-cytology
#11
Giorgio Bogani, Francesca Taverna, Claudia Lombardo, Chiara Borghi, Fabio Martinelli, Mauro Signorelli, Umberto Leone Roberti Maggiore, Valentina Chiappa, Cono Scaffa, Antonino Ditto, Domenica Lorusso, Francesco Raspagliesi
OBJECTIVE: To evaluate the outcomes of women diagnosed with high-risk HPV without cytology evidence of cervical dysplasia. METHODS: The present retrospective observational study enrolled consecutive women aged at least 18 years diagnosed with high-risk HPV types with negative cytology results at the National Cancer Institute, Milan, Italy, between January 1, 2005, and December 31, 2015. The development of cervical intraepithelial neoplasia (CIN) was assessed. RESULTS: There were 212 patients with high-risk HPV infections with negative cytology included in the analysis...
April 7, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28380684/effectiveness-of-photodynamic-therapy-in-elimination-of-hpv-16-and-hpv-18-associated-with-cin-i-in-mexican-women
#12
Elizabeth Maldonado Alvarado, M Olivia Osorio Peralta, Alejandra Moreno Vázquez, L Alejandra Martínez Guzmán, M Eugenia Melo Petrone, Z Iveth Enriquez Mar, D Estela Jovel Galdamez, Bárbara Carrión Solana, Guadalupe Balderas Martínez, Eduarda Parra, R Inés Castellanos Oliveros, R Linda Bello Leiva, Araceli Espinosa Montesinos, Citlalli Barrera Mendoza, S Eugenia Medina García, Eva Ramón Gallegos
The present study aimed to determine the effectiveness of photodynamic therapy (PDT), using δ-aminolevulinic acid (5-ALA), in the elimination of premalignant cervical lesions in Mexican patients with human papillomavirus (HPV) infection and/or cervical intraepithelial neoplasia (CIN). Thirty women diagnosed with CIN I and/or positive for HPV participated in the study. Topical 6% 5-ALA in gel form was applied to the uterine cervix; after 4 h, the lesion area was irradiated with a light dose of 200 J/cm(2) at 635 nm...
April 5, 2017: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/28380476/vaginal-neoplasia-induced-by-an-unusual-papillomavirus-subtype-in-a-woman-with-inherited-chromosomally-integrated-human-herpesvirus-type-6a
#13
Maxime Pichon, Alexandre Gaymard, Karine Lebail-Carval, Emilie Frobert, Etienne Beaufils, Gautier Chene, Massimo Tommasino, Bruno Lina, Pascal Gaucherand, Agnès Gautheret-Dejean, Pascale Bonnafous, Tarik Gheit, Annie Buenerd, Gery Lamblin, Yahia Mekki
We describe here a case of high-grade vaginal squamous lesion in a 54-year-old woman with a papillomaviruses (HPV) genital infection that developed from a cervical low-grade squamous intraepithelial lesion (SIL) to a high-grade SIL (H-SIL) on cytological examination. A colposcopy exam led to the detection of suspect vaginal lesions with granulomatous infiltrations, which were classified as a Vaginal Intra-Epithelial Neoplasia grade 2 after pathologists' analyses. After a laser vaginal surgery and a loop excision of the transformation zone, the analyses of the anatomical pieces using a near-complete HPV screening panel revealed an HPV-4 infection that was not detected before in cervical smears...
April 6, 2017: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/28378404/a-cross-sectional-study-on-hpv-testing-with-type-16-18-genotyping-for-cervical-cancer-screening-in-11-064-chinese-women
#14
Qiongyan Wu, Xiumin Zhao, Yunfeng Fu, Xinyu Wang, Xiaofei Zhang, Xun Tian, Bei Cheng, Bingjian Lu, Xiao Yu, Suqiu Lan, Weiguo Lu, Ding Ma, Xiaodong Cheng, Xing Xie
Cytology-based cervical cancer screening is restricted because of a lack of cytologists. Thus, HPV-based instead of cytology-based screening may be a more suitable strategy in China. Here, we assessed the effectiveness of HPV testing (Cobas(®) 4800 Test, Roche) and HPV-based programs to detect high-grade cervical intraepithelial neoplasia (CIN) or cancer compared with cytology (Thinprep, Hologic) and cytology-based programs through a cross-sectional study in 11,064 Chinese women aged 21-65 years who were enrolled from Longyou County in Zhejiang Province, China...
April 4, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28374937/physical-after-effects-of-colposcopy-and-related-procedures-and-their-inter-relationship-with-psychological-distress-a-longitudinal-survey
#15
Mairead O'Connor, Katie O'Brien, Jo Waller, Pamela Gallagher, Tom D'Arcy, Grainne Flannelly, Cara M Martin, Judith McRae, Walter Prendiville, Carmel Ruttle, Christine White, Loretto Pilkington, John J O'Leary, Linda Sharp
OBJECTIVES: To estimate prevalence of post-colposcopy physical after-effects and investigate associations between these and subsequent psychological distress. DESIGN: Longitudinal survey. SETTING: Two hospital-based colposcopy clinics. POPULATION: Women with abnormal cytology who underwent colposcopy (+/- related procedures). METHODS: Questionnaires were mailed to women 4-, 8- and 12-months post-colposcopy...
April 4, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28365957/psychological-effects-of-concurrent-cytology-and-colposcopy-testing-in-women-referred-to-cancer-counseling-outpatient-clinic-in-belgrade
#16
Ljiljana Markovic-Denic, Svetlana Popovac, Olivera Djuric, Zivko Perisic, Snezana Rakic
PURPOSE: To investigate the psychological effects of PAP smear and colposcopy performed simultaneously and receipt of abnormal tests' results on women's well-being and quality of life (QoL) using different relative questionnaires. METHODS: A prospective cohort study included 324 women with abnormal PAP smear result obtained at the primary care centers, requiring repeat smear test and colposcopy in our hospital. Questionnaires regarding the patient demographic characteristics, 7-point Likert scales which indicate concern about the smear and colposcopy results and risk of developing cervical cancer, Bek Anxiety Inventory (BAI), European QoL questionnaire - Euro QoL (EQ-5D) and visual analogue scale (EQ VAS) were used...
January 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/28365936/new-software-for-collecting-data-from-the-organized-cervical-cancer-screening-program-in-serbia-are-we-on-the-threshold-of-a-new-screening-registry-a-multicentric-study
#17
Tamara Naumovic, Vesna Lakic, Ana Jovicevic, Dragan Ilic, Predrag Milosevic, Vesna Stevic-Gajic, Ana Antonijevic, Nada Milovanovic, Ivica Magdic, Rajko Koricanac, Sasa Malkov, Igor Grkavac, Milos Mihajlovic, Slavisa Djuricic, Branislava Zivkovic, Uros Stegic, Zorka Milovanovic, Dejan Opric, Marija Knezevic, Verica Jovanovic, Zoran Todorovic, Dusan Todorovic
PURPOSE: The purpose of this study was to present the Screening Registry and the results of organized cervical cancer screening program (OCCSP) in the Republic of Serbia using a database made as an output model, linked with the Screening Registry. METHODS: Data were respectively collected over a onemonth period from 3 state primary health care centers (and related hospitals/clinical center) in central Serbia in which OCCSP was conducted. The sample consisted of women of the target population (25 to 64 years old) who responded the call for Pap test...
January 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/28363186/a-model-to-evaluate-the-costs-and-clinical-effectiveness-of-human-papilloma-virus-screening-compared-with-annual-papanicolaou-cytology-in-germany
#18
Karl Ulrich Petry, Cordula Barth, Jürgen Wasem, Anja Neumann
OBJECTIVES: We modelled human papilloma virus (HPV) primary screening scenarios compared with Pap cytology to evaluate clinical effectiveness and projected annual costs in Germany. STUDY DESIGN: A Markov cohort model was built to compare the budget impact of annual Pap cytology with different 5-yearly HPV screening scenarios: (1) a positive HPV test followed by Pap cytology; (2) a positive HPV test followed by p16/Ki-67 dual-stained cytology; (3) a positive HPV test followed by colposcopy if HPV-16/18-positive or p16/Ki-67 dual-stained cytology if positive for other subtypes; (4) co-testing with HPV and Pap...
March 19, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28352328/distribution-of-human-papillomavirus-genotypes-in-cervical-lesions
#19
Li Ma, Xiao Cong, Mai Shi, Xiu-Hong Wang, Hai-Yan Liu, Mei-Lu Bian
The aims of the present study were to investigate the distribution of human papillomavirus (HPV) genotypes in cervical lesions, and the association between different HPV genotypes and cervical lesions. Between January 2013 and June 2014, the HPV type determinations of nucleic acid by use of fluorescence polymerase chain reaction (PCR) method of 15,192 outpatients in China-Japan Friendship Hospital were performed and the infection status was analyzed. The results showed that: i) 2,366 Cases were HPV positive and 12,826 cases were HPV negative, the overall infection rate was 15...
February 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28340468/the-prevalence-of-hiv-among-women-with-high-grade-cervical-smear-abnormalities-in-birmingham-united-kingdom-a-prospective-cohort-study
#20
Najum S Qureshi, K Manavi
OBJECTIVE: The aim of the study was twofold: 1. To assess the acceptance for HIV screening in women attending Colposcopy clinic 2. To determine the prevalence of HIV in women presenting with high-grade cervical smear abnormalities. DESIGN: A prospective study. SETTING: Colposcopy clinic, Birmingham Women's Hospital, UK. POPULATION: Patients attending colposcopy clinic. MAIN OUTCOME MEASURES: To determine acceptance of HIV testing and prevalence in colposcopy patients with High-grade cervical smear abnormalities...
March 18, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
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