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https://www.readbyqxmd.com/read/29777323/andriod-device-based-cervical-cancer-screening-for-resource-poor-settings
#1
Vidya Kudva, Keerthana Prasad, Shyamala Guruvare
Visual inspection with acetic acid (VIA) is an effective, affordable and simple test for cervical cancer screening in resource-poor settings. But considerable expertise is needed to differentiate cancerous lesions from normal lesions, which is lacking in developing countries. Many studies have attempted automation of cervical cancer detection from cervix images acquired during the VIA process. These studies used images acquired through colposcopy or cervicography. However, colposcopy is expensive and hence is not feasible as a screening tool in resource-poor settings...
May 18, 2018: Journal of Digital Imaging: the Official Journal of the Society for Computer Applications in Radiology
https://www.readbyqxmd.com/read/29770625/risks-of-cervical-intraepithelial-neoplasia-grade-3-or-invasive-cancers-in-ascus-women-with-different-management-a-population-based-cohort-study
#2
Yi Jou Tai, Yun Yuan Chen, Huang Cheng Hsu, Chun Ju Chiang, San Lin You, Chi An Chen, Wen Fang Cheng
OBJECTIVE: To investigate the progression risk of atypical squamous cells of undetermined significance (ASCUS) with different clinical managements. METHODS: Women with their first diagnosis of ASCUS cytology were retrieved from the national cervical cancer screening database and linked to the national health insurance research database to identify the management of these women. The incidences of developing cervical intraepithelial neoplasia grade 3 and invasive cervical cancer (CIN3+) were calculated, and the hazard ratios (HRs) were estimated using a Cox proportional hazards model...
March 20, 2018: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/29770617/the-use-of-conization-to-identify-and-treat-severe-lesions-among-prediagnosed-cin1-and-2-patients-in-japan
#3
Mikio Mikami, Masae Ikeda, Hidetaka Sato, Haruko Iwase, Takayuki Enomoto, Yoichi Kobayashi, Hidetaka Katabuchi
OBJECTIVE: To evaluate the clinical efficiency of identifying patients with suspicious severe lesions by conization among prediagnosed cervical intraepithelial neoplasia (CIN) 1 and 2 patients in Japan. METHODS: The data in a Japanese nation-wide registry for cervical cancer (2009 and 2011) was collected to analyze the clinical efficacy of pre- and postdiagnosis for 13,215 Japanese women who underwent treatment by conization. Their preoperative and postoperative histologic findings and clinical outcomes were evaluated using standard statistical procedures including clinical and demographic characteristics...
March 8, 2018: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/29768678/the-ideal-strategy-for-cervical-cancer-screening-in-japan-result-from-the-fukui-cervical-cancer-screening-study
#4
T Kurokawa, T Onuma, A Shinagawa, Y Chino, M Kobayashi, Y Yoshida
OBJECTIVE: The aims of the Fukui Cervical Cancer Screening (FCCS) study are to determine the frequency of women with high-risk HPV (hrHPV), whether HPV16 or HPV18 (HPV16/18), in the Japanese cancer screening population for the first time and to identify the best strategy for cervical cancer screening in Japan. METHODS: This study enrolled 7,584 women ≥25 years of age who were undergoing routine screening. All women underwent liquid-based cytology and cobas HPV tests...
May 16, 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/29762429/the-results-of-an-italian-quality-assurance-program-support-the-new-american-society-for-colposcopy-and-cervical-pathology-recommendations-for-colposcopy-practice
#5
Paola Garutti, Paolo Cristiani, Stefano Ferretti, Priscilla Sassoli de Bianchi, Alessandra Ravaioli, Lauro Bucchi
No abstract text is available yet for this article.
May 14, 2018: Journal of Lower Genital Tract Disease
https://www.readbyqxmd.com/read/29762428/outcomes-of-conservative-management-of-high-grade-squamous-intraepithelial-lesions-in-young-women
#6
Marette H Lee, Sarah J Finlayson, Ksenia Gukova, Gillian Hanley, Dianne Miller, Leslie Ann Sadownik
OBJECTIVE: The aim of the study was to determine regression rates of cervical intraepithelial neoplasia (CIN) 2 and 3 in women younger than 24 years, followed conservatively for up to 24 months. MATERIALS AND METHODS: This is a retrospective chart review of colposcopy patients in clinic database based on the following: (1) younger than 24 years at first visit; (2) first visit January 1, 2010, to May 31, 2013, and at least 1 follow-up visit after diagnosis; (3) histologic diagnosis of CIN2+; and (4) optimal conservative management (observation for up to 24 months or to 24 years, whichever occurred first)...
May 4, 2018: Journal of Lower Genital Tract Disease
https://www.readbyqxmd.com/read/29762164/cervical-cancer-screening-among-hiv-infected-women-in-an-urban-u-s-safety-net-healthcare-system
#7
Arti Barnes, Andrea C Betts, Eric K Borton, Joanne M Sanders, Sandi L Pruitt, Claudia Werner, Andres Bran, Carolee D Estelle, Bijal A Balasubramanian, Stephen J Inrig, Ethan A Halm, Celette Sugg Skinner, Jasmin A Tiro
OBJECTIVE: Little is known about cervical cancer screening and results patterns among HIV infected (HIV+) women in real-world healthcare settings. We characterized two periods of screening opportunity. DESIGN: Retrospective cohort. SETTING: U.S. safety-net healthcare system in Dallas County, Texas. SUBJECTS: We analyzed data from electronic medical records (EMR) of 1,490 HIV+ women receiving care 2010-2014. MAIN OUTCOME MEASURES: At baseline, we categorized a woman's Pap status 15 months prior to index date as under-screened (vs...
May 11, 2018: AIDS
https://www.readbyqxmd.com/read/29759001/betwixt-and-between-well-and-sick-in-cervical-precancer-canadian-women-s-experiences-of-recurring-hpv-infections-and-hpv-vaccination
#8
Michelle Wyndham-West, Nancy Durand, Aimee Santoro
Background This research fuses the experiences of a precancer diagnosis with the decision-making surrounding a vaccine that can protect against human papillomavirus strains that women may not have been exposed to. The interviewee cohort is of note as half the women were in their 30s and 40s and 75% were over the age of 26. These groupings are often overlooked in media discourses and narrative research surrounding human papillomavirus and the human papillomavirus vaccine. Purpose Womens' diagnoses and treatment experiences, including colposcopies, biopsies, and Loop Electrosurgical Excision Procedures, are chronicled to highlight a liminal, precancerous state-one in which they are not deemed healthy, but nor have they been diagnosed with cancer...
January 1, 2018: Canadian Journal of Nursing Research, Revue Canadienne de Recherche en Sciences Infirmières
https://www.readbyqxmd.com/read/29758205/performance-of-p16-ki67-dual-staining-in-triaging-hr-hpv-positive-population-during-cervical-cancer-screening-in-the-younger-women
#9
Qiu-Ping Qian, Xiaoan Zhang, Bo Ding, Shi-Wen Jiang, Ze-Min Li, Mu-Lan Ren, Yang Shen
BACKGROUND: Cervical cancer is the most common malignancy from the female reproductive tract, and usually develops from low-grade or high-grade squamous intraepithelial lesions (LSIL or HSIL). Detecting the precancerous lesion during the LSIL-HSIL-invasive cancer sequelae can effectively interrupt the oncogenesis and decrease the incidence of invasive carcinoma. The aim of this study is to evaluate the performance of P16/Ki67 dual staining in triaging hr-HPV-positive population. METHODS: Conventional gynecological examination, cervical cytology and hr-HPV testing were given to all patients...
May 11, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29747341/-prevalence-of-high-risk-hpv-and-its-distribution-in-cervical-precancerous-lesions-among-35-64-years-old-women-who-received-cervical-cancer-screening-in-beijing
#10
J Shen, L L Gao, Y Zhang, L L Han, J D Wang
Objective: To study the prevalence of high-risk HPV (HR HPV) in women who accepted cervical cancer screening in Beijing and its distribution in cervical precancerous lesions. Methods: From January 2014 to March 2015, all women aged 35-64 years old and received free screening in institutions of cervical cancer in Beijing were recruited. Stratified cluster random sampling method was used in selecting 31 091 women for gynecological examination and genotyping of HR-HPV. Those positive for HR-HPV (except for HPV 16/18) were examined for cervical cell...
May 6, 2018: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/29747338/-role-of-hpv-viral-loads-in-random-biopsy-under-normal-colposcopy
#11
X Q Xu, L Zhang, S Y Hu, Remila Rezhake, X L Zhao, F Chen, X Zhang, Q J Pan, Y L Qiao, F H Zhao
Objective: To explore the role of HPV viral loads in random biopsy under normal colposcopy. Methods: 908 atypical squamous cells of undetermined significance (ASC-US) and HPV positive women, recruited in cluster sampling in 9 provinces including 5 urban areas and 9 rural areas in China from 1999 to 2008 and meeting the inclusion and exclusion criteria were included in this analysis. According to relative light units/cutoff (RLU/CO) value, subjects were stratified as low (286 cases), intermediate (311 cases) and high (311 cases) viral load groups...
May 6, 2018: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/29747337/-comparison-of-screening-performance-between-primary-high-risk-hpv-screening-and-high-risk-hpv-screening-plus-liquid-based-cytology-cotesting-in-diagnosis-of-cervical-precancerous-or-cancerous-lesions
#12
X L Zhao, Rezhake Remila, S Y Hu, L Zhang, X Q Xu, F Chen, Q J Pan, X Zhang, F H Zhao
Objective: To evaluate and compare the screening performance of primary high-risk HPV(HR-HPV) screening and HR-HPV screening plus liquid-based cytology (LBC) cotesting in diagnosis of cervical cancer and precancerous lesions (CIN2+). Methods: We pooled 17 population-based cross-sectional studies which were conducted across China from 1999 to 2008. After obtaining informed consent, all women received liquid-based cytology(LBC)testing, HR-HPV DNA testing. Totally 28 777 women with complete LBC, HPV and biopsy results were included in the final analysis...
May 6, 2018: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/29734247/clinical-and-economic-value-of-p16ink4a-for-the-differential-diagnosis-of-morphologic-cervical-intraepithelial-neoplasia-2
#13
Vanina S Fishkel, Fernando C Monge, Felicitas M von Petery, Karen E Tapper, Teresa M Peña, Florencia Torres, Fernando A Poletta, Jorge F Elgart, Alejandra Avagnina, Valeria Denninghoff
The detection of high-grade intraepithelial lesions requires highly sensitive and specific methods that allow more accurate diagnoses. This contributes to a proper management of preneoplastic lesions, thus avoiding overtreatment. The purpose of this study was to analyze the value of immunostaining for p16 in the morphologic assessment of cervical intraepithelial neoplasia 2 lesions, to help differentiate between low-grade (p16-negative) and high-grade (p16-positive) squamous intraepithelial lesions. The direct medical cost of the treatment of cervical intraepithelial neoplasia 2 morphologic lesions was estimated...
May 4, 2018: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/29733302/excess-cost-of-cervical-cancer-screening-beyond-recommended-screening-ages-or-after-hysterectomy-in-a-single-institution
#14
Deanna Teoh, Gretchen Hultman, McKenzie DeKam, Rachel Isaksson Vogel, Levi S Downs, Melissa A Geller, Chap Le, Genevieve Melton, Shalini Kulasingam
OBJECTIVE: The aim of the study was to estimate the excess cost of guideline nonadherent cervical cancer screening in women beyond the recommended screening ages or posthysterectomy in a single healthcare system. MATERIALS AND METHODS: All Pap tests performed between September 1, 2012, and August 31, 2014, in women younger than 21 years, older than 65 years, or after hysterectomy, were coded as guideline adherent or nonadherent per the 2012 America Society of Colposcopy and Clinical Pathology guidelines...
May 3, 2018: Journal of Lower Genital Tract Disease
https://www.readbyqxmd.com/read/29707775/impact-of-hpv-vaccination-on-outcome-of-cervical-cytology-screening-in-denmark-a-register-based-cohort-study
#15
Lise Holst Thamsborg, George Napolitano, Lise Grupe Larsen, Elsebeth Lynge
4vHPV-vaccination has been tested in randomized controlled trials under almost ideal conditions, and studies of real-life use have compared outcome between vaccinated and unvaccinated women from the same birth cohort and mostly before screening age. Here we present the first - to our knowledge - evaluation of the impact of the 4vHPV-vaccination in real-life without selection bias in the reported data. The study has been carried out by comparing the results after first cervical screening between an HPV-vaccinated and an unvaccinated birth cohort, consisting of women born in Denmark in 1993 and 1983, respectively...
April 29, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29707519/molecular-signatures-of-high-grade-cervical-lesions
#16
Andreia M Porcari, Fernanda Negrão, Guilherme Lucas Tripodi, Denise Rocha Pitta, Elisabete Aparecida Campos, Douglas Munhoz Montis, Aline M A Martins, Marcos N Eberlin, Sophie F M Derchain
Cervical cancer is the fourth most common neoplasia in women and the infection with human papilloma virus (HPV) is its necessary cause. Screening methods, currently based on cytology and HPV DNA tests, display low specificity/sensitivity, reducing the efficacy of cervical cancer screening programs. Herein, molecular signatures of cervical cytologic specimens revealed by liquid chromatography-mass spectrometry (LC-MS), were tested in their ability to provide a metabolomic screening for cervical cancer. These molecules were tested whether they could clinically differentiate insignificant HPV infections from precancerous lesions...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29704442/factors-affecting-residual-recurrent-cervical-intraepithelial-neoplasia-after-cervical-conization-with-negative-margins
#17
Aiping Fan, Chen Wang, Cha Han, Yingmei Wang, Fengxia Xue, Liqin Zhang
OBJECTIVE: To identify factors for predicting residual or recurrent cervical intraepithelial neoplasia (CIN) after cervical conization with negative margins. METHODS: A total of 172 patients with histologically verified high-grade squamous intraepithelial lesions who underwent conization with negative margins were recruited at the General Hospital of Tianjin Medical University from December 2006 to January 2016. Follow-up comprised clinical examination, liquid-based cytology test, HPV DNA genotyping test, colposcopy assessment, and if indicated, colposcopy-directed punch biopsy...
April 28, 2018: Journal of Medical Virology
https://www.readbyqxmd.com/read/29690868/oncological-and-reproductive-outcomes-of-adenocarcinoma-in-situ-of-the-cervix-managed-with-the-loop-electrosurgical-excision-procedure
#18
Huimin Bai, Jun Liu, Qiuxi Wang, Ying Feng, Tong Lou, Shuzhen Wang, Yue Wang, Mulan Jin, Zhenyu Zhang
BACKGROUND: The standard treatment for cervical adenocarcinoma in situ (AIS) is hysterectomy, which is a more aggressive treatment than that used for squamous intraepithelial lesions. Several previous studies have primarily demonstrated that the loop electrosurgical excision procedure (LEEP) is as safe and effective as cold knife cone (CKC) biopsy when AIS is unexpectedly found in a loop excision. This study evaluated the safety of LEEP as the initial treatment for patients with AIS who were strictly selected and evaluated before and after loop resection...
April 24, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29681462/the-onclarity-human-papillomavirus-trial-design-methods-and-baseline-results
#19
Mark H Stoler, Thomas C Wright, Valentin Parvu, Laurence Vaughan, Karen Yanson, Karen Eckert, Tobi Karchmer, Salma Kodsi, Charles K Cooper
OBJECTIVES: The baseline phase of the Onclarity trial was conducted to determine the screening performance of the Onclarity human papillomavirus (HPV) assay for detecting cervical cancer and precancer (≥CIN2) during triage of women ≥21 years with ASC-US cytology, as an adjunct test in women ≥30 years with normal cytology and for primary screening (HPV alone) in women ≥25 years. METHODS: 33,858 women ≥21 years were enrolled during routine clinic visits...
April 19, 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/29678360/validation-of-a-new-hpv-self-sampling-device-for-cervical-cancer-screening-the-cervical-and-self-sample-in-screening-cassis-study
#20
Mariam El-Zein, Sheila Bouten, Karolina Louvanto, Lucy Gilbert, Walter Gotlieb, Robert Hemmings, Marcel A Behr, Eduardo L Franco, Victoria Liang, Claudia Martins, Silvy Duarte, Natalia Sarban, Patricia Geddes, Ana Massa, Kathrin Samios, Siham Aboufadl, Sophie Verdon, Cynthia Pereria, Isabelle Lacroix
OBJECTIVE: We compared the self-sampling performance of the newly designed HerSwab™ device with a physician-collected cervical sample and another self-sample using the cobas® PCR Female swab for the detection of cervical intraepithelial neoplasia (CIN) and cancer. METHODS: Women referred for colposcopy at McGill University affiliated hospital clinics collected two consecutive self-samples, one with HerSwab™ and one with cobas® swab, after receiving instructions...
April 17, 2018: Gynecologic Oncology
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