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https://www.readbyqxmd.com/read/29333334/the-effect-of-the-2012-asccp-consensus-guideline-for-abnormal-cervical-cytology-on-resident-colposcopy-training
#1
Cori-Ann M Hirai, Bliss Kaneshiro, Mark K Hiraoka
The primary objective was to determine the theoretical number of colposcopies at a resident clinic if the 2012 American Society for Colposcopy and Cervical Pathology (ASCCP) guidelines were applied. The secondary objective was to determine the actual number of colposcopies before and after the ASCCP guidelines. This was a two-part descriptive study. The first part applied the 2012 ASCCP guidelines to all pre-guideline colposcopy cases at a single resident clinic. These theoretical results were then compared to the actual number of colposcopies...
January 2018: Hawai'i Journal of Medicine & Public Health: a Journal of Asia Pacific Medicine & Public Health
https://www.readbyqxmd.com/read/29327350/adopting-innovation-in-gynaecology-the-introduction-of-e-consult
#2
Rebecca Mann, Peter H M van de Weijer
OBJECTIVE: To describe the development of an e-consultation service as part of the triaging and grading process of referrals and to report on the efficacy and safety of such a service. METHODS: All gynaecology e-consults in the study period June 2015 to March 2016 were retrospectively reviewed. The outcomes of interest were the initial reduction in first face-to-face hospital visits, and the rate of re-referrals. Acute admission for the same reason, a subsequent diagnosis of underlying (pre)-malignancy, or patient death from the condition related to the index referral were selected as measures for patient safety...
January 12, 2018: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/29320507/hpv-prevalence-and-hpv-related-dysplasia-in-elderly-women
#3
Ruth S Hermansson, Matts Olovsson, Emelie Hoxell, Annika K Lindström
INTRODUCTION: In Sweden, where screening ends at the age of 60, about 30% of the cervical cancer cases occur in women older than 60. The aim of the present study was to investigate the prevalence of HPV and cervical dysplasia in women of 60 years and above. PATIENTS AND METHODS: From September 2013 until June 2015, 1051 women aged 60-89 years (mean 68 years) were sampled for an HPV test when attending an outpatient gynecology clinic. Women with positive results had a second HPV test and liquid based cytology (LBC), after 3...
2018: PloS One
https://www.readbyqxmd.com/read/29309102/variations-in-progression-and-regression-of-precancerous-lesions-of-the-uterine-cervix-on-cytology-testing-among-women-of-different-races
#4
Daniel Martingano, Audrey Renson, Alison Jane Martingano, Francis X Martingano
Background: Although not incorporated into current cervical cancer screening guidelines, racial differences are known to persist in both occurrence of and outcomes related to cervical cancer. Objective: To compare the differences in progression and regression of precancerous lesions of the uterine cervix on cervical cytologic analysis among women of different races who adhered to cervical cancer screening recommendations and follow-up. Methods: Retrospective cohort study comparing differences in precancerous lesion diagnoses for patients receiving adequate evaluation according to the American Society for Colposcopy and Cervical Pathology guidelines...
January 1, 2018: Journal of the American Osteopathic Association
https://www.readbyqxmd.com/read/29302852/acceptability-of-self-sample-human-papillomavirus-testing-among-thai-women-visiting-a-colposcopy-clinic
#5
Natacha Phoolcharoen, Nuttavut Kantathavorn, Wasanai Krisorakun, Chantanee Taepisitpong, Waraphorn Krongthong, Siriporn Saeloo
We offered self-sampling devices to 250 women who visited the colposcopy clinic at Chulabhorn Hospital, Bangkok, Thailand from March 1 to June 30, 2015. Participants received instruction about the vaginal self-sample method and collected the specimen themselves, before being examined by the physician who obtained a conventional cervical specimen. Participating women's attitudes and feelings regarding the self-sample method were explored using a short questionnaire. Of the 247 eligible women, more than 90% of participants rated the self-sample method as very good to excellent for convenience, comfort, and safety...
January 4, 2018: Journal of Community Health
https://www.readbyqxmd.com/read/29302584/modified-cervicography-and-visual-inspection-with-acetic-acid-as-an-alternative-screening-method-for-cervical-precancerous-lesions
#6
Gatot Purwoto, Hasra Depiesa Dianika, Andre Putra, Sigit Purbadi, Laila Nuranna
Background: We compared the diagnostic accuracy between visual inspection with acetic acid (VIA) and modified cervicography as an alternative screening method for cervical precancerous lesions. Methods: A diagnostic cross-sectional study was performed at the outpatient clinic at an Indonesian national referral hospital from February until April 2015. We collected samples from patients who sequentially underwent VIA examination, modified cervicography, and colposcopy...
December 2017: Journal of Cancer Prevention
https://www.readbyqxmd.com/read/29285369/clinical-significance-of-atypical-squamous-cells-of-undetermined-significance-after-treatment-for-cervical-intraepithelial-grade-3-neoplasia-a-retrospective-single-center-cohort-study
#7
Toshimichi Onuma, Kimihisa Tajima, Kumiko Sato, Katsushige Hattori, Shin Fukuda, Takahiro Tsuji, Yoshio Yoshida
The aim of the present study was to evaluate the clinical significance of atypical squamous cells of undetermined significance (ASC-US) following cervical conization for cervical intraepithelial neoplasia (CIN) grade 3. This study was a retrospective cohort analysis. The medical records of women treated with conization for CIN 2-3 were reviewed and 142 patients with CIN 3 who had been diagnosed using the conization specimens were selected. The mean follow-up period after conization was 41.8 months. Cytological abnormalities after conization were observed in 19...
December 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29279588/comparison-of-the-sensitivity-and-specificity-of-p16-ki-67-dual-staining-and-hpv-dna-testing-of-abnormal-cervical-cytology-in-the-detection-of-histology-proven-cervical-intraepithelial-neoplasia-grade-2-and-above-cin-2
#8
T K Y Tay, K L Lim, M H Hilmy, A A Thike, S T Goh, L H Song, J S G Hwang, S Mantoo
INTRODUCTION: Human papillomavirus (HPV) testing is used as a means of triaging cervico-vaginal smears with low grade squamous abnormalities or as part of co-testing with cytology. While HPV testing has a high sensitivity, it has a low specificity in detecting cervical intraepithelial neoplasia grade 2 and above (CIN 2+) leading to unnecessary colposcopy referrals. We investigate the accuracy of the p16/Ki-67 dual immunocytochemical stain in determining the presence of CIN 2+ lesions on histology and its potential as a superior biomarker for triage...
December 2017: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/29235108/initial-results-of-population-based-cervical-cancer-screening-program-using-hpv-testing-in-one-million-turkish-women
#9
Murat Gultekin, Mujdegul Zayifoglu Karaca, Irem Kucukyildiz, Selin Dundar, Guledal Boztas, Hatice Semra Turan, Ezgi Hacikamiloglu, Kamil Murtuza, Bekir Keskinkilic, Irfan Sencan
OBJECTIVE: To evaluate the Turkey's nationwide HPV DNA screening program on the basis of first 1 million screened women. METHODS: Women over age 30 were invited for population based screening via HPV DNA and conventional cytology. Samples were collected by family physicians and the evaluations and reports had been performed in the National Central HPV laboratories. RESULTS: The acceptance rate for HPV based cervical cancer screening after first invitation was nearly 36...
December 13, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29212399/conservative-management-of-cin2-national-audit-of-british-society-for-colposcopy-and-cervical-pathology-members-opinion
#10
Madeleine Macdonald, John H F Smith, John A Tidy, Julia E Palmer
There is no doubt that organised cervical screening programmes have significantly reduced the rates of cervical cancer by detection and treatment of high-grade cervical intraepithelial neoplasia (CIN2, CIN3). National UK guidelines do not differentiate between CIN2 and CIN3 as separate entities and recommend treatment for both, although a degree of uncertainty exists regarding the natural history of CIN2. This national survey of British Society for Colposcopy and Cervical Pathology members aimed to assess attitudes towards conservative management (CM) of CIN2 in the UK and identify potential selection criteria...
December 6, 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29208879/oncoe6-positivity-among-via-positive-suspected-cases-from-colposcopy-clinic-of-mymensingh-medical-college-hospital-mymensingh
#11
F Nahar, M A Hossain, S K Paul, M U Ahmed, S Khatun, N Akhter, G R Bhuiyan, S A Nasreen, S Roy, T K Barman, N Laskar, H Begum, S Abedin, N Haque, S Ahmed, N Kobayashi
Cervical cancer is a major world health problem for women. It is the fourth most leading cause of death in women around the world. High risk HPV DNA has been shown to be present in 99.7% of cervical cancers worldwide. Oncoprotein E6 and E7 play an important role in the development of cervical cancer which can be detected by OncoE6 cervical test. This Cross sectional observational study was performed to detect E6 Oncoprotein from cervical swab by OncoE6 cervical test. Following universal safety precautions a total of 47 endocervical swabs were collected from Colposcopy clinic of Obstetrics and Gynaecology department of Mymensingh Medical College Hospital (MMCH), Mymensingh, Bangladesh from January 2015 to December 2015...
October 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/29179270/-clinical-outcome-and-high-risk-factor-for-residual-lesion-analysis-of-hsil-half-a-year-after-loop-electrosurgical-excision-procedure-a-clinical-study-of-1-502-cases
#12
L Liu, L M Chen, X Tao, F Dai, L P Guo, H W Zhang, X R Zhou, L Sui
Objective: To analyze clinical outcome of high-grade squamous intraepithelial lesion (HSIL) half a year after loop electrosurgical excision procedure (LEEP) and explore the high risk factor of residual cervical HSIL. Methods: The retrospective study was carried out on 1 502 patients who underwent LEEP, with HSIL in the LEEP histopathology from January 2011 to December 2013 at Obstetrics and Gynecology Hospital of Fudan University to confer the difference between residual group and non-residual group after 6 months of the leep conization...
November 25, 2017: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/29179268/-natural-changes-of-high-risk-hpv-in-women-with-negative-for-intraepithelial-lesion-or-malignancy-a-prospective-1-year-study
#13
Y He, Y M Wu, C H Yin, Y N Geng, S L Yang, L D Kang
Objective: To investigate the natural changes of high-risk HPV (HR-HPV) in women with negative for intraepithelial lesion or malignancy (NILM) for regulating HR-HPV screening. Methods: Four hundred and thirty-three newly-diagnosed women were enrolled from January 1st, 2015 to December 31, 2015 in Beijing Obstetrics and Gynecology Hospital. The ages of these patients were between 22 and 74 years, the average age was (45±21) years old. Two hundred and sixty-three cases were less than 50 years old, 170 cases were more and equal to 50 years old...
November 25, 2017: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/29174874/cervical-cancer-screening-and-follow-up-procedures-in-women-age-21-years-following-new-screening-guidelines
#14
Alexandra M Foxx, Yuwei Zhu, Edward Mitchel, Sayeh Nikpay, Dineo Khabele, Marie R Griffin
PURPOSE: The 2009 American College of Obstetricians and Gynecologists guidelines recommended no cervical cancer screening before age 21 years. We examined changes in screening, diagnostic, and treatment procedures for cervical dysplasia after guideline introduction, and cost implications. METHODS: We studied Davidson County women aged 18-20 years, enrolled in Tennessee Medicaid, 2006-2014. We identified those with at least one Papanicolaou (Pap) test, human papillomavirus detection test, colposcopy, or excisional dysplasia treatment annually via Current Procedural Terminology coding...
November 22, 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/29169614/human-papillomavirus-viral-load-as-a-useful-triage-tool-for-non-16-18-high-risk-human-papillomavirus-positive-women-a-prospective-screening-cohort-study
#15
Li Dong, Margaret Z Wang, Xue-Lian Zhao, Rui-Mei Feng, Shang-Ying Hu, Qian Zhang, Jennifer S Smith, You-Lin Qiao, Fang-Hui Zhao
OBJECTIVE: ASCCP cervical cancer screening guidelines recommend triaging high-risk human papillomavirus (hrHPV) positive women with cytology and genotyping, but cytology is often unavailable in resource-limited areas. We compared the long-term risk of cervical cancer and precancers among type-specific hrHPV-positive women triaged by viral load to cytology and visual inspection with acetic acid (VIA). METHODS: A cohort of 1742 Chinese women was screened with cytology, VIA, and Hybrid Capture 2 (HC2) test and followed for ten years...
November 20, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/29162106/extent-regional-variation-and-impact-of-gynecologist-payment-models-in-routine-pelvic-examinations-a-nationwide-cross-sectional-study
#16
Ingvild Mathiesen Rosenlund, Linda Leivseth, Ingard Nilsen, Olav Helge Førde, Arthur Revhaug
BACKGROUND: Based on moderate quality evidence, routine pelvic examination is strongly recommended against in asymptomatic women. The aims of this study was to quantify the extent of routine pelvic examinations within specialized health care in Norway, to assess if the use of these services differs across hospital referral regions and to assess if the use of colposcopy and ultrasound differs with gynecologists' payment models. METHODS: Nationwide cross-sectional study including all women aged 18 years and older in Norway in the years 2014-16 (2,038,747)...
November 21, 2017: BMC Women's Health
https://www.readbyqxmd.com/read/29143102/diagnostic-performance-of-hpv-e6-e7-mrna-assay-for-detection-of-cervical-high-grade-intraepithelial-neoplasia-and-cancer-among-women-with-ascus-papanicolaou-smears
#17
Chenchen Ren, Yuanhang Zhu, Li Yang, Xiaoan Zhang, Ling Liu, Chunying Ren
PURPOSE: The aim of this study was to investigate the clinical performance of high risk (HR) HPV E6/E7 mRNA assay in detecting cervical high-grade intraepithelial neoplasia and cancer among women with atypical squamous cells of undetermined significance (ASCUS) Papanicolaou (Pap) smears. METHODS: A total of 160 patients with ASCUS who underwent HR-HPV DNA assay, HR-HPV E6/E7 mRNA assay and colposcopy biopsy at Third Affiliated Hospital of Zhengzhou University, China, from December 2015 to March 2017, were enrolled...
November 15, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29137390/a-cocktail-of-p16-ink4a-and-ki-67-p16-ink4a-and-minichromosome-maintenance-protein-2-as-triage-tests-for-human-papillomavirus-primary-cervical-cancer-screening
#18
Hai-Rui Wang, Yu-Cong Li, Hui-Qin Guo, Lu-Lu Yu, Zeni Wu, Jian Yin, Guang-Dong Liao, Yi-Min Qu, Yu Jiang, Dong Wang, Wen Chen
Most human papillomavirus (HPV) infections are transient and additional triage approaches should be built after HPV-based primary cervical cancer screening. We evaluated the accuracy of p16/Ki-67 and p16/mcm2 dual staining as biomarkers for triaging HPV positive women in China. 4070 participants aged 35 to 64 years attending ongoing cervical cancer screening were enrolled in 2015-2016. Cervical exfoliated cells were collected for HPV DNA analysis and the residual positive specimens were tested for liquid-based cytology and biomarkers...
October 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/29132873/hpv-genotype-profile-in-a-norwegian-cohort-with-asc-us-and-lsil-cytology-with-three-year-cumulative-risk-of-high-grade-cervical-neoplasia
#19
A K Lie, A Tropé, G B Skare, T Bjørge, C M Jonassen, K Brusegard, S Lönnberg
OBJECTIVE: To explore the HPVgenotype profile in Norwegian women with ASC-US/LSIL cytology and the subsequent risk of high-grade cervical neoplasia (CIN 3+). METHODS: In this observational study delayed triage of ASC-US/LSIL of 6058 women were included from 2005 to 2010. High-risk HPV detection with Hybrid Capture 2 (HC2) was used and the HC2+ cases were genotyped with in-house nmPCR. Women were followed-up for histologically confirmed CIN3+ within three years of index HPV test by linkage to the screening databases at the Cancer Registry of Norway...
November 11, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/29131134/mannose-binding-lectin-is-not-acting-as-a-biomarker-for-the-progression-of-pre-invasive-lesions-of-invasive-cervical-cancer
#20
Carlos Afonso Maestri, Renato Nisihara, Guilherme P Ramos, Hellen Weinschutz Mendes, Iara Messias-Reason, Newton Sérgio de Carvalho
OBJECTIVE: To evaluate serum concentrations of mannose binding lectin (MBL) in women presenting with different human papilloma virus (HPV)-associated cervical lesions. SUBJECTS AND METHODS: A total of 364 women, who underwent screening for cervical cancer or treatment at Erasto Gaertner Cancer Hospital (HEG), Curitiba, Southern region, Brazil, were enrolled in the study. Based on latest cervical colposcopy-guided biopsy results, the women were divided into four groups: cervical intraepithelial neoplasia (CIN) CIN-I (n=54); CIN-II (n=72); CIN-III (n=145) and invasive cancer (n=93)...
November 7, 2017: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
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