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Colposcopy

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https://www.readbyqxmd.com/read/28213603/women-s-experiences-with-cervical-cancer-screening-in-a-colposcopy-referral-clinic-in-cape-town-south-africa-a-qualitative-analysis
#1
Mariette Momberg, Matthys H Botha, Frederick H Van der Merwe, Jennifer Moodley
OBJECTIVE: The aim of this study was to explore and understand women's experience with cervical cancer screening and with the referral pathways for abnormal Papanicolau (Pap) smears. DESIGN AND SETTING: Focus group discussions were conducted with first time colposcopy clinic attendees at a tertiary hospital colposcopy clinic in Cape Town, South Africa during November 2014. A thematic analysis was conducted to identify key themes. Initial coding categories were drawn from the interview guide...
February 17, 2017: BMJ Open
https://www.readbyqxmd.com/read/28190541/predictors-of-adherence-to-follow-up-recommendations-after-an-abnormal-pap-smear-among-underserved-inner-city-women
#2
Suzanne M Miller, Erin K Tagai, Kuang-Yi Wen, Minsun Lee, Siu-Kuen Azor Hui, Deirdre Kurtz, John Scarpato, Enrique Hernandez
OBJECTIVES: This study aimed to identify cognitive-affective predictors of adherence to initial diagnostic colposcopy and 6-month follow-up recommendations among underserved women. METHODS: A secondary data analysis was completed of a randomized clinical trial assessing tailored telephone counseling for colposcopy adherence after an abnormal screening Pap smear among 210 underserved inner-city women. RESULTS: Adherence to initial diagnostic colposcopy was significantly associated with greater self-efficacy (OR=1...
January 31, 2017: Patient Education and Counseling
https://www.readbyqxmd.com/read/28182083/endometriosis-mimicking-glandular-atypia-in-a-cervical-cytology
#3
Paula A Rodriguez-Urrego, Isabel C Dulcey-Hormiga, Luis E Barrera-Herrera, David A Suarez-Zamora, Mauricio A Palau-Lazaro, Catalina Buritica-Cifuentes
Endometriosis involving the uterine cervix is a rare condition that can lead to diagnostic errors in the interpretation of Pap smear. We report the case of a 41-year-old patient in whom the initial Pap smear revealed three-dimensional clusters of glandular cells with elongated nuclei, occasional mitosis, and atypia, which was interpreted as atypical glandular cells, not otherwise specified (NOS). The patient was taken to colposcopy and endocervical biopsy. Colposcopy was normal and the biopsy presented glands with elongated nuclei and surrounded by endometrial stroma admixed with normal endocervical glands...
January 2017: Journal of Cytology
https://www.readbyqxmd.com/read/28157825/pain-sensation-during-colposcopy-and-cervical-biopsy-with-or-without-local-anesthesia-a-randomized-trial
#4
Mari Kiviharju, Ilkka Kalliala, Pekka Nieminen, Tadeusz Dyba, Annika Riska, Maija Jakobsson
OBJECTIVE: The aim of the study was to determine whether an injection of a local anesthetic is more painful than a cervical punch biopsy without local anesthesia. MATERIALS AND METHODS: The study was a randomized controlled trial, conducted at the Helsinki University Central Hospital. It consisted of 204 women referred for colposcopic assessments. Half of them were randomized to receive local anesthesia before their cervical punch biopsies. After the injection of the local anesthetic, the cervical punch biopsy, and the endocervical curettage, the women scored their actual pain using a 10-cm visual analog scale (VAS)...
February 3, 2017: Journal of Lower Genital Tract Disease
https://www.readbyqxmd.com/read/28157250/the-incidence-of-cervical-intraepithelial-neoplasia-in-a-population-of-pregnant-women-with-an-abnormal-cytology
#5
Dominik Pruski, Blanka Malkowska-Walczak, Aleksandra Paluszkiewicz, Witold Kędzia
OBJECTIVES: To assess the incidence of cervical intraepithelial neoplasia - SIL and cervical cancer in a population of pregnant women with an abnormal cytology. MATERIAL AND METHODS: In pregnant women with abnormal cytology results according to The Bethesda System, a verifying diagnostics was carried out, including colposcopy and cervical biopsy. RESULTS: The most common histological and oncologic diagnosis in the whole study group of pregnant women were HGSIL changes, covering cervical intraepithelial neoplasia of medium and high grade - CIN 2 and CIN 3...
2017: Ginekologia Polska
https://www.readbyqxmd.com/read/28125861/immediate-referral-to-colposcopy-versus-cytological-surveillance-for-minor-cervical-cytological-abnormalities-in-the-absence-of-hpv-test
#6
REVIEW
Maria Kyrgiou, Ilkka E J Kalliala, Anita Mitra, Christina Fotopoulou, Sadaf Ghaem-Maghami, Pierre Pl Martin-Hirsch, Margaret Cruickshank, Marc Arbyn, Evangelos Paraskevaidis
BACKGROUND: A significant number of women are diagnosed with minor cytological abnormalities on cervical screening. Many authorities recommend surveillance as spontaneous regression might occur. However, attendance for cytological follow-up decreases with time and might put some women at risk of developing invasive disease. OBJECTIVES: To assess the optimum management strategy for women with minor cervical cytological abnormalities (atypical squamous cells of undetermined significance - ASCUS or low-grade squamous intra-epithelial lesions - LSIL) at primary screening in the absence of HPV (human papillomavirus) DNA test...
January 26, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28122530/via-vili-is-more-suitable-for-cervical-cancer-prevention-in-chinese-poverty-stricken-region-a-health-economic-evaluation
#7
Yu Xie, Xiaodong Tan, Haiyan Shao, Qing Liu, Jiyu Tou, Yuling Zhang, Qiong Luo, Qunying Xiang
BACKGROUND: Screening is the main preventive method for cervical cancer in developing countries, but each type of screening has advantages and disadvantages. To investigate the most suitable method for low-income areas in China, we conducted a health economic analysis comparing three methods: visual inspection with acetic acid and Lugol's iodine (VIA/VILI), ThinPrep cytology test (TCT), and human papillomavirus (HPV) test. METHODS: We recruited 3086 women aged 35-65 years using cluster random sampling...
January 25, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28121939/multiple-preinvasive-and-invasive-hpv-related-lesions-of-the-anogenital-tract-in-a-female-patient-with-hiv-infection-a-case-report
#8
Nicolò Clemente, Lara Alessandrini, Emanuela Vaccher, Antonino De Paoli, Monica Buttignol, Vincenzo Canzonieri, Francesco Sopracordevole
RATIONALE: Patients with human immunodeficiency virus (HIV) infection have been shown to be at increased risk for high-risk human papillomavirus (HR-HPV) infection of the anogenital tract. Furthermore, in the last decades, the introduction of highly active antiretroviral therapy (HAART) has increased the longevity of these patients who now live long enough to develop HPV-related cancers; hence, the impact of HPV infection on HIV-positive patients is of increasing concern. PATIENT CONCERNS: We reported the case of an HIV-positive female patient on HAART with a good virological and immunological response and with a long history of HPV-related intraepithelial and invasive lesions of the anogenital tract...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28120391/cervical-cancer-incidence-after-screening-with-hpv-cytology-and-visual-methods-18-year-follow-up-of-the-guanacaste-cohort
#9
Ana Cecilia Rodríguez, Carlos Ávila, Rolando Herrero, Allan Hildesheim, Mark E Sherman, Robert D Burk, Jorge Morales, Mario Alfaro, Diego Guillén, María Ethel Trejos, Rosa María Vargas, Guillermo Torres, Mark Schiffman
Testing negative for human papillomavirus (HPV) predicts long-term reassurance against invasive cervical cancer (ICC). To provide realistic estimates of effectiveness for new screening programs, we studied ICC risk after a 7-year repeated multi-method screening effort. In 1993-94, 10,049 women aged 18-97 were enrolled into a population-based cohort study of cervical HPV in Guanacaste, Costa Rica. Women were screened at different intervals according to enrollment results. Each visit (mean 3.2, 90% attendance) included split-sample conventional, automated, and liquid-based cytology; visual inspection; cervicography; and PCR-based HPV testing...
January 24, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28120382/a-3-year-interval-is-too-short-for-re-screening-hpv-negative-women-a-population-based-cohort-study
#10
Manuel Zorzi, Helena Frayle, Martina Rizzi, Chiara Fedato, Massimo Rugge, Maria Gabriella Penon, Alessandra Bertazzo, Susanna Callegaro, Marisa Campagnolo, Fausta Ortu, Annarosa Del Mistro
OBJECTIVE: To compare the results of the first round and of re-screening 3 years after a negative human papillomavirus (HPV) test in women attending two HPV-based screening programs. DESIGN: Population-based cohort study. SETTING: Two cervical service screening programmes in Italy. POPULATION: Women aged 25-64 years invited to screening from April 2009 to October 2015. METHODS: Eligible women were invited to undergo an HPV test...
January 24, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28116194/endocervical-carcinogenesis-and-hpv-vaccination-an-occasional-circumstance-or-a-gap-in-the-chain
#11
Georgios-Marios Makris, Petros Karakitsos, Eugenia Kotsifa, Niki Margari, Nikiforita Poulakaki, Theodoros N Sergentanis, Marco-Johannes Battista, Charalampos Chrelias, Nicolaos Papantoniou
As a result of the Human Papillomavirus (HPV) vaccination program, the prevalence of precancerous dysplasia and invasive cervical cancer has substantially decreased. In this brief report, we present a case of a young patient who was diagnosed with in situ adenocarcinoma of the cervix. This 30-year-old female had completed the HPV vaccination after she became sexually active and has been undergoing annual gynecological assessments, including clinical examination and Pap test, all of which had been negative. This year, her Pap test revealed a low grade squamous intraepithelial lesion (LGSIL) and additionally a colposcopy was performed...
2017: Case Reports in Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28108997/risk-of-high-grade-precancerous-lesions-and-invasive-cancers-in-high-risk-hpv-positive-women-with-normal-cervix-or-cin-1-at-baseline-a-population-based-cohort-study
#12
Srabani Mittal, Partha Basu, Richard Muwonge, Dipanwita Banerjee, Ishita Ghosh, Mitali Mukherjee Sengupta, Pradip Das, Priatosh Dey, Ranajit Mandal, Chinmay Panda, Jaydip Biswas, Rengaswamy Sankaranarayanan
Infection with High-risk Human Papillomavirus (HR-HPV) is transient and clears on its own in majority of the women. Only a few women who have persistent infection may finally develop Cervical Intraepithelial Neoplasia (CIN) or cervical cancer in later years. The risk of progression in the HR-HPV positive women with normal cervix or low grade lesion on colposcopy and histopathology at baseline is less studied. We performed a longitudinal study on 650 HR-HPV positive women with colposcopy and/or histopathology proved normal or CIN1 diagnosis at baselineto assess the cumulative risk of development of high-grade CIN...
January 20, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28102931/the-impact-of-hpv-type-on-colposcopy-performance-in-women-offered-hpv-immunisation-in-a-catch-up-vaccine-programme-a-two-centre-observational-study
#13
Ami Munro, Collette Gillespie, Seonaidh Cotton, Camille Busby-Earle, Kim Kavanagh, Kate Cuschieri, Heather Cubie, Chris Robertson, Louise Smart, Kevin Pollock, Catherine Moore, Timothy Palmer, Margaret E Cruickshank
OBJECTIVE: To determine if HPV immunisation has affected the prevalence of HPV genotypes and colposcopic features of CIN in young women referred for colposcopy. DESIGN: A two-centre observational study including vaccinated and unvaccinated women. SETTING: Colposcopy clinics serving two health regions in Scotland, UK. POPULATION: 361 women aged 20-25 years attending colposcopy following an abnormal cervical cytology result at routine cervical screening...
January 19, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28102928/reduction-in-colposcopy-workload-and-associated-clinical-activity-following-hpv-catch-up-vaccination-programme-in-scotland-an-ecological-study
#14
M E Cruickshank, J Pan, S C Cotton, K Kavanagh, C Robertson, K Cuschieri, H Cubie, T Palmer, K G Pollock
OBJECTIVE: To measure patterns of clinical activity at colposcopy before and after vaccinated women entered the Scottish Cervical Screening Programme (SCSP). DESIGN: Population-based observational study using nationally collected data. SETTING: Scottish colposcopy clinics. SAMPLE: All women with a date of birth on or after 1 January 1985 who attended colposcopy in Scotland between 2008-2014. METHODS: Routinely collected data from the Scottish National Colposcopy Clinical Information Audit System (NCCIAS) was extracted, including: referral criteria, referral cervical cytology, colposcopic findings, clinical procedures and histology results...
January 19, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28100595/determinants-of-viral-oncogenes-e6-e7-mrna-over-expression-in-a-population-based-large-sample-of-women-infected-by-high-risk-hpv-types
#15
Paolo Giorgi Rossi, Simonetta Bisanzi, Elena Allia, Alessandra Mongia, Francesca Carozzi, Anna Gillio-Tos, Laura De Marco, Guglielmo Ronco, Daniela Gustinucci, Annarosa Del Mistro, Helena Frayle, Anna Iossa, Giulia Fantacci, Giampaolo Pompei, Elena Cesarini, Simonetta Bulletti, Basilio Passamonti, Martina Rizzi, Maria Gabriella Penon, Alessandra Barca, Maria Benevolo
Cervical cancer screening by HPV-DNA testing with cytology triage is more effective than cytology testing. Compared to cytology, the HPV-DNA test higher sensitivity, that allows better protection with longer intervals, makes it necessary to triage the women with a positive result to compensate its lower specificity.We are conducting a large randomized clinical trial (New Technologies for Cervical Cancer 2, NTCC2) within organized population-based screening programs in Italy using HPV-DNA as primary screening test, to evaluate, by Aptima HPV Assay (Hologic), HPV E6-E7 mRNA as triage test in comparison to cytology...
January 18, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28099735/negative-hpv-testing-among-patients-with-biopsy-proven-cervical-intraepithelial-neoplasia-grade-2-3-or-cervical-cancer
#16
Eduardo González-Bosquet, Sergi Fernandez, Sally Sabra, Jose M Lailla
OBJECTIVE: To determine the proportion of patients diagnosed with cervical cancer or cervical intraepithelial neoplasia grade 2 or 3 (CIN 2/3) despite testing negative for HPV. METHODS: A prospective study was conducted at a university hospital in Barcelona, Spain, between March 2003 and January 2015 among women with abnormal cytology results according to the Bethesda classification system. All participants underwent HPV testing, cytology, and colposcopy. RESULTS: Among 1376 participants, 609 (44...
February 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28096198/comparison-of-triage-strategies-for-hpv-positive-women-canadian-cervical-cancer-screening-trial-results
#17
Sandra Dakdouk Isidean, Marie-Hélène Mayrand, Agnihotram V Ramanakumar, Isabel Rodrigues, Alex Ferenczy, Sam Ratnam, François Coutlée, Eduardo L Franco
BACKGROUND: High-risk human papillomavirus (HR-HPV) testing has become a preferred cervical cancer screening strategy in some countries due to its superior sensitivity over cytology-based methods for identifying cervical intraepithelial neoplasia of grade 2 or worse (CIN2+). Improved sensitivity has been accompanied by reductions in specificity and concerns regarding over-screening and over-treatment of women with transient or non-progressing HR-HPV infections. Triage of HR-HPV+ women to colposcopy is, thus, warranted for appropriate management and treatment...
January 17, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28095411/optimal-management-strategies-for-primary-hpv-testing-for-cervical-screening-cost-effectiveness-evaluation-for-the-national-cervical-screening-program-in-australia
#18
Kate T Simms, Michaela Hall, Megan A Smith, Jie-Bin Lew, Suzanne Hughes, Susan Yuill, Ian Hammond, Marion Saville, Karen Canfell
BACKGROUND: Several countries are implementing a transition to HPV testing for cervical screening in response to the introduction of HPV vaccination and evidence indicating that HPV screening is more effective than cytology. In Australia, a 2017 transition from 2-yearly conventional cytology in 18-20 to 69 years to 5-yearly primary HPV screening in 25 to 74 years will involve partial genotyping for HPV 16/18 with direct referral to colposcopy for this higher risk group. The objective of this study was to determine the optimal management of women positive for other high-risk HPV types (not 16/18) ('OHR HPV')...
2017: PloS One
https://www.readbyqxmd.com/read/28094038/triaging-hpv-positive-women-with-p16-ki-67-dual-stained-cytology-results-from-a-sub-study-nested-into-the-athena-trial
#19
Thomas C Wright, Catherine M Behrens, James Ranger-Moore, Susanne Rehm, Abha Sharma, Mark H Stoler, Ruediger Ridder
OBJECTIVES: In addition to genotyping for HPV16/18, dual-immunostaining for p16/Ki-67 has shown promise as a triage of HPV-positive women. We assessed the performance of p16/Ki-67 dual-stained cytology for triaging HPV-positive women undergoing primary HPV screening. METHODS: All women ≥25years with valid cervical biopsy and cobas® HPV Test results from the cross-sectional phase of ATHENA who were referred to colposcopy (n=7727) were eligible for enrolment. p16/Ki-67 dual-stained cytology was retrospectively performed on residual cytologic material collected into a second liquid-based cytology vial during the ATHENA enrolment visit...
January 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28069334/prevalence-of-anal-infection-due-to-high-risk-human-papillomavirus-and-analysis-of-e2-gene-integrity-among-women-with-cervical-abnormalities
#20
María Del Refugio Gonzalez-Losa, Marylin Puerto-Solís, Guadalupe Ayora-Talavera, Jesús Gómez-Carvallo, Alejandra Euán-López, José I Cisneros-Cutz, Ariel Rosado-López, Jesúa Echeverría Salazar, Laura Conde-Ferráez
BACKGROUND: High-risk human papillomaviruses (HR-HPV) infection has been associated with 90% of anal cancer cases. Women with abnormal cytology are a high-risk group to develop anal neoplasia. The aim of this study is to describe the prevalence and epidemiology of HR-HPV 16, 18, 45, and 58 anal infections in women with cervical abnormalities, as well as to assess E2 gene integrity. METHODS: A cross-sectional study was performed on 311 cervical and 311 anal samples from patients with abnormal cytology in two colposcopy clinics in Yucatan, Mexico...
January 6, 2017: Enfermedades Infecciosas y Microbiología Clínica
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