keyword
Keywords Bone tumors, soft tissue tumor...

Bone tumors, soft tissue tumors , bone metastatic disease,

https://read.qxmd.com/read/37840619/spontaneous-acute-epidural-hematoma-associated-with-metastatic-hepatocellular-carcinoma-a-case-report
#21
Kang Hee Ahn, Han Seung Ryu, Moon-Soo Han, Yoo Duk Choi, Sung-Pil Joo
Spontaneous acute epidural hematoma (AEDH) co-occurring with metastatic hepatocellular carcinoma (HCC) of the skull is rare, with only 7 documented cases in existing literature. This report describes the case of a 42-year-old man who presented with decreased consciousness following intermittent headaches following minor head trauma. Computed tomography imaging revealed an AEDH, prompting surgical intervention. Despite preliminary assumptions linking the causes of the trauma, surgical exploration revealed no evidence of traumatic injury...
September 2023: Korean Journal of Neurotrauma
https://read.qxmd.com/read/37832362/extraskeletal-ewing-s-sarcoma-of-the-thigh-with-lung-and-bone-metastasis-case-report
#22
Abebaw Muhabaw Zegeye, Birlew T Alemayehu, Degalem Tilahun Worku, Kirubel Addisu Abera, Samuel Addisu Abera, Bewketu Abebe Alemu
INTRODUCTION AND IMPORTANCE: Extraskeletal Ewing's sarcoma is an uncommon tumor with a devastating prognosis and a very high mortality rate, particularly in metastatic forms, it primarily affects young people mainly in the 2nd to 4th decades of life. It can affect different parts of the body, without a particular clinical presentation which delays diagnosis. CASE PRESENTATION: 12-year-old male patient presented with swelling over the left proximal thigh of 7 months duration associated with pain and limping...
November 2023: International Journal of Surgery Case Reports
https://read.qxmd.com/read/37824083/outcomes-of-long-bones-treated-with-carbon-fiber-nails-for-oncologic-indications-international-multi-institutional-study
#23
JOURNAL ARTICLE
Santiago A Lozano-Calderon, Zeger Rijs, Oliver Q Groot, Marie W Su, Joseph O Werenski, Nelson Merchan, Caleb M Yeung, Alisha Sodhi, Emily Berner, Vania Oliveira, Giuseppe Bianchi, Eric Staals, Debora Lana, Davide Donati, Ortal Segal, Stefano Marone, Raimondo Piana, Simone De Meo, Pietro Pellegrino, Nicola Ratto, Carmine Zoccali, Maurizio Scorianz, Cecilia Tomai, Guido Scoccianti, Domenico Andrea Campanacci, Lorenzo Andreani, Silvia de Franco, Michele Boffano, Manuel Peleteiro Pensado, Irene Barrientos Ruiz, Esperanza Holgado Moreno, Eduardo Jose Ortiz-Cruz, Michiel van de Sande
BACKGROUND: Intramedullary nail fixation is commonly used for prophylactic stabilization of impending and fixation of complete pathological fractures of the long bones. However, metallic artifacts complicate imaging evaluation for bone healing or tumor progression and postoperative radiation planning. Carbon-fiber implants have gained popularity as an alternative, given their radiolucency and superior axial bending. This study evaluates incidences of mechanical and nonmechanical complications...
October 31, 2023: Journal of the American Academy of Orthopaedic Surgeons
https://read.qxmd.com/read/37797747/impact-of-consolidative-radiation-on-overall-and-progression-free-survival-in-pediatric-adolescent-and-young-adult-metastatic-bone-and-soft-tissue-sarcoma
#24
JOURNAL ARTICLE
Leslie Chang, Anjali D'Amiano, Rohini Bhatia, Gayane Yenokyan, Nicolas J Llosa, Brian H Ladle, Christian F Meyer, Adam S Levin, Christine A Pratilas, Matthew Ladra, Sahaja Acharya
PURPOSE: To determine the association between consolidative radiation (RT) and survival in children, adolescents, and young adults with metastatic sarcoma. METHODS AND MATERIALS: Eligibility criteria included patients aged ≤39 years with newly diagnosed metastatic bone or soft tissue sarcoma who completed local control of the primary tumor without disease progression. Consolidative RT was defined as RT to all known sites of metastatic disease. The Kaplan-Meier method was used to estimate overall survival (OS) and progression-free survival (PFS)...
October 3, 2023: International Journal of Radiation Oncology, Biology, Physics
https://read.qxmd.com/read/37785392/an-analysis-of-patients-treated-with-stereotactic-body-radiotherapy-for-metastatic-urinary-tract-tumors-to-identify-predictors-of-response
#25
JOURNAL ARTICLE
N Oh, J Nakashima, J S Chadha, J A Kish, B Manley, J Pow-Sang, A Yu, J Zhang, P Spiess, M S Chatwal, R Jain, L W Zemp, M Poch, W J Sexton, R Li, S M Gilbert, P A S Johnstone, J F Torres-Roca, K Yamoah, D Grass
PURPOSE/OBJECTIVE(S): To identify selection criteria linked to outcomes in patients treated with stereotactic body radiotherapy (SBRT) for metastatic tumors of the urinary tract (UT). MATERIALS/METHODS: Single institution retrospective analysis of SBRT treated patients for oligometastatic/progressive UT tumors from 2006-2022. Charts were queried for M1 status at diagnosis or during disease course, treatment details (surgery, SBRT, systemic therapy), metabolic status (diabetes [DM], BMI) and outcomes...
October 1, 2023: International Journal of Radiation Oncology, Biology, Physics
https://read.qxmd.com/read/37620851/composite-hemangioendothelioma-report-of-two-cases-located-in-bone-and-review-of-the-literature
#26
JOURNAL ARTICLE
Yunyang Deng, Mei Li
BACKGROUND: Composite hemangioendothelioma (CHE) is a rare intermediate-grade vascular tumor characterized by a complex histologic component. It occasionally metastasizes, but local recurrence is not uncommon. CHE is mainly located in the extremities' distal dermis and subcutaneous soft tissues. It is rarely located in the bone. We report here two cases originally occurred in bone. CASE PRESENTATION: The first case of CHE occurred solely on the left pubis. The second case is a patient post-resection of CHE in the manubrium sterni 10 years ago [1], who presented with multiple lesions in the left ilium and T6, T12 vertebra...
August 24, 2023: BMC Musculoskeletal Disorders
https://read.qxmd.com/read/37580891/tyrosine-kinase-inhibitor-therapy-in-pediatric-sarcoma-prognostic-implications-of-pulmonary-metastatic-cavitation
#27
JOURNAL ARTICLE
Wipawee Morakote, Lisa C Adams, Shakthi K Ramasamy, Sheri L Spunt, Lucia Baratto, Tie Liang, Heike E Daldrup-Link
PURPOSES: This study aims to ascertain the prevalence of cavitations in pulmonary metastases among pediatric and young adult patients with sarcoma undergoing tyrosine kinase inhibitor (TKI) therapy, and assess whether cavitation can predict clinical response and survival outcomes. METHODS: In a single-center retrospective analysis, we examined chest computed tomography (CT) scans of 17 patients (median age 16 years; age range: 4-25 years) with histopathologically confirmed bone (n = 10) or soft tissue (n = 7) sarcoma who underwent TKI treatment for lung metastases...
November 2023: Pediatric Blood & Cancer
https://read.qxmd.com/read/37559588/breast-cancer-metastases-to-the-thyroid-and-stomach-a-case-report
#28
Xue Bai, Canbin Fang, Binliang Liu, Jiayi Huagn, Xuelian Chen, Xiaofeng Xie, Qiuyi Zhang, Meidi Liu, Jinyan Liang, Jinfeng Guo, Lin Song, Xiaofeng Lan, Liping Chen, Suni Huang, Wencui Deng, Zhenzhen Luo, Caiwen Du
The most common sites of metastasis for breast cancer are the soft tissues, bones, lungs, liver and brain; however, metastases to the gastrointestinal tract and thyroid gland from breast cancer rarely occur. The present study describes the case of a 30-year-old woman who developed gastric and thyroid metastases 5 years after her initial diagnosis of invasive ductal breast carcinoma. The initial pathological diagnosis when receiving modified radical mastectomy was invasive ductal carcinoma, and further immunohistochemical examination revealed the cancer to be estrogen receptor (-), progesterone receptor (-), human epidermal growth factor receptor 2 (HER2; ++) and Ki-67 (70%)...
September 2023: Oncology Letters
https://read.qxmd.com/read/37466577/incidence-of-and-risk-factors-for-thromboembolism-after-endoprosthetic-reconstruction-in-musculoskeletal-oncology-patients
#29
RANDOMIZED CONTROLLED TRIAL
Samir Sabharwal, Christa L LiBrizzi, Jonathan A Forsberg, Carol D Morris, Adam S Levin
BACKGROUND: The aim of the present study was to assess the incidence of and risk factors for thromboembolic events-including assessment of the intraoperative use of tranexamic acid and postoperative use of chemical thromboprophylaxis-in patients undergoing operative treatment of primary bone or soft-tissue sarcoma or oligometastatic bone disease. METHODS: This study was performed as a secondary analysis of prospective data collected from the Prophylactic Antibiotic Regimens in Tumor Surgery (PARITY) randomized controlled trial, which included 604 patients ≥12 years old who underwent surgical resection and endoprosthetic reconstruction for either primary bone or soft-tissue sarcoma or oligometastatic disease of the femur or tibia...
July 19, 2023: Journal of Bone and Joint Surgery. American Volume
https://read.qxmd.com/read/37461232/keratin-positive-giant-cell-rich-tumor-of-bone-harboring-an-hmga2-ncor2-fusion-two-cases-including-a-patient-with-metastatic-disease-and-review-of-the-literature
#30
JOURNAL ARTICLE
Ashley Patton, Hakan Ilaslan, Susan M Armstrong, Ahmed Bakhshwin, Yu-Wei Cheng, Farooq Minhas, Karen J Fritchie
Giant cell-rich lesions of bone represent a heterogeneous group of entities which classically include giant cell tumor of bone, aneurysmal bone cyst, nonossifying fibroma, and Brown tumor of hyperparathyroidism. A recently described subset of giant cell-rich tumors involving bone and soft tissue has been characterized by recurrent HMGA2::NCOR2 fusions and keratin expression. The overlapping clinical, radiographic, and morphological features of these giant cell-rich lesions provide a unique diagnostic challenge, particularly on biopsy...
July 17, 2023: International Journal of Surgical Pathology
https://read.qxmd.com/read/37458332/complications-of-cryoprobe-cryoablation-as-a-surgical-adjuvant-for-the-treatment-of-metastatic-carcinoma-to-bone-benign-bone-tumors-and-soft-tissue-tumors-a-series-of-148-patients
#31
JOURNAL ARTICLE
Brandon S Gettleman, Mary K Richardson, Mina Ayad, Alexander B Christ, Lawrence R Menendez
BACKGROUND AND OBJECTIVE: This study describes the complication profile of modern cryoablation utilizing probes as an adjuvant during open surgical treatment of orthopedic tumors. METHODS: A retrospective, single-surgeon study was performed for patients receiving cryoprobe cryoablation. Demographic information, malignancy-related and operative details, and clinical courses were collected. Outcomes assessed included rates of complications, recurrence, and correlations between the number of probes or cryoablation cycles performed...
July 17, 2023: Journal of Surgical Oncology
https://read.qxmd.com/read/37414444/-18-f-fdg-pet-ct-in-the-initial-staging-and-restaging-of-soft-tissue-or-bone-sarcoma-in-patients-with-negative-or-equivocal-findings-for-metastases-or-limited-recurrence-on-conventional-work-up-results-of-a-prospective-multicenter-registry
#32
JOURNAL ARTICLE
Ur Metser, Roshini Kulanthaivelu, Abdulazeez Salawu, Albiruni Razak, Victor Mak, Xuan Li, Deanna L Langer, Pamela MacCrostie, Amit Singunkar
The purpose of this study was to determine the impact of [18 F]FDG PET/CT on the initial staging, restaging, clinical management, and outcomes of patients with soft-tissue and bone sarcomas. Methods: This single-arm, prospective multicenter registry enrolled 304 patients with 320 [18 F]FDG PET/CT scans (November 2018 to October 2021). Eligibility included the initial staging of a grade 2 or higher or ungradable soft-tissue or bone sarcoma, with negative or equivocal findings for nodal or distant metastases on conventional imaging before curative-intent therapy, or restaging of patients with a history of treated sarcoma with a suspicion or confirmation of local recurrence or limited metastatic disease who were being considered for curative-intent or salvage therapy...
July 6, 2023: Journal of Nuclear Medicine
https://read.qxmd.com/read/37403815/consensus-recommendations-in-the-management-of-ewing-sarcoma-from-the-national-ewing-sarcoma-tumor-board
#33
REVIEW
Ajay Gupta, Richard F Riedel, Chirag Shah, Scott C Borinstein, Michael S Isakoff, Rashmi Chugh, Jeremy M Rosenblum, Erin S Murphy, Shauna R Campbell, Catherine M Albert, Stacey Zahler, Stefanie M Thomas, Matteo Trucco
Ewing sarcoma (ES) is a malignant tumor of bone and soft tissue that most often occurs in adolescents and young adults. Despite an international coordinated approach, several nuances, discrepancies, and debates remain in defining the standard of care for treating ES. In this review, the authors leverage the expertise assembled by formation of the National Ewing Sarcoma Tumor Board, a multi-institution, multidisciplinary virtual tumor board that meets monthly to discuss complicated and challenging cases of ES...
July 5, 2023: Cancer
https://read.qxmd.com/read/37314590/elbow-hemiarthroplasty-with-a-3d-printed-prosthesis-for-distal-humeral-bone-defects-after-tumor-excision-a-case-report
#34
JOURNAL ARTICLE
Yingkang Zhu, Shuo Gong, Jin Dai, Lei Zhou
INTRODUCTION: The distal humerus is a rare site for primary and metastatic bone tumors. Due to the scarcity of cases and lack of standardized surgical strategies, it is often difficult for surgeons to choose the right choice. The application of a 3D-printed prosthesis with hemiarthroplasty for the treatment of the distal humerus after tumor resection can be a very effective option. CASE PRESENTATION: We present a clinical case of a 3D-printed distal humeral prosthesis for the treatment of bone defects caused by metastatic bone tumors...
June 14, 2023: 3D Printing in Medicine
https://read.qxmd.com/read/37270505/needle-tract-seeding-of-a-sclerosing-epithelioid-fibrosarcoma-in-a-biopsy-tract-a-case-report
#35
JOURNAL ARTICLE
Masafumi Kawai, Shinji Miwa, Norio Yamamoto, Katsuhiro Hayashi, Akihiko Takeuchi, Kentaro Igarashi, Yuta Taniguchi, Yoshihiro Araki, Hirotaka Yonezawa, Takayuki Nojima, Hiroyuki Tsuchiya
BACKGROUND: A sclerosing epithelioid fibrosarcoma (SEF) is an uncommon tumor of the deep soft tissue. An SEF has been described as a low-grade tumor with high local recurrence and metastatic rates. Generally, in bone and soft tissue tumors, a resection of the biopsy route is recommended; however, there is limited evidence with respect to the dissemination of the tumor tissue during a needle biopsy. CASE PRESENTATION: A mass in the right pelvic cavity, with no symptoms, was observed in a 45-year-old woman during a gynecological examination...
June 3, 2023: BMC Musculoskeletal Disorders
https://read.qxmd.com/read/37198611/breast-cancer-with-scalp-metastases-a-case-report
#36
JOURNAL ARTICLE
Ahmad M Abdulraheem, Duha Naji, Ammar N Al Heyasat, Mohammad Alhasan, Nidal M Almasri, Raghad Odeh
BACKGROUND: While breast cancer is the most common cancer in women, cutaneous metastases are rare in breast cancer. Additionally, scalp involvement in breast cancer metastasis is extremely rare. That being said, scalp lesions should always be thoroughly investigated to distinguish metastatic lesions from other neoplasms. CASE PRESENTATION: A 47-year-old female Middle-Eastern patient presented with metastatic breast cancer in the lungs, bone, liver, and brain with no signs of multiple organ failure, in addition to cutaneous metastases, including the scalp...
May 18, 2023: Journal of Medical Case Reports
https://read.qxmd.com/read/37143346/rare-dedifferentiated-periosteal-chondrosarcoma-with-11-year-metastatic-relapse-a-case-report
#37
JOURNAL ARTICLE
Matthew A Gasparro, Linus Lee, Gayathri Vijayakumar, Charles A Gusho, Matthew W Colman, Steven Gitelis, Ira Miller, Alan T Blank
A 50-year-old man presented for evaluation of a periscapular mass. Biopsy suggested a low-grade chondrosarcoma; however, the resected specimen revealed a grade 2 chondrosarcoma with a low-grade dedifferentiated mesenchymal component. The mass multiply recurred as chondrosarcoma without a dedifferentiated component before the patient developed lung metastases of chondrosarcoma without a dedifferentiated component 11 years after the initial diagnosis and died of disease. This is one of the first reported cases of a dedifferentiated chondrosarcoma with low-grade dedifferentiated component...
May 4, 2023: International Journal of Surgical Pathology
https://read.qxmd.com/read/36923600/comparison-of-psma-based-18-f-dcfpyl-pet-ct-and-tc-99m-mdp-bone-scan-in-detection-of-bone-metastasis-in-prostate-cancer
#38
JOURNAL ARTICLE
Zenus J Wilson, Guofan Xu, Sanjit O Tewari, Yang Lu
While Tc-99m MDP bone scan (BS) remains the conventional standard for detection of bone metastasis in prostate cancer, newly FDA-approved imaging with PSMA-based 18 F-DCFPyL PET/CT has shown promise for early detection of metastatic disease. However, a paucity of data remains in the diagnostic accuracy of PSMA PET/CT in detecting bone metastasis compared to BS. This retrospective study included 91 patients who received both BS and PSMA PET/CT within a 3-month interval from August 2021 to February 2022. Separate concurrent primary cancer, interval PSA levels greater than a 2-fold difference (or absolute difference >1 ng/ml) between the two studies were excluded...
2023: American Journal of Nuclear Medicine and Molecular Imaging
https://read.qxmd.com/read/36908679/new-trends-in-the-surgical-management-of-soft-tissue-sarcoma-the-role-of-preoperative-biopsy
#39
REVIEW
Efstathios T Pavlidis, Theodoros E Pavlidis
Soft tissue sarcoma (STS) accounts for 1% of all malignant neoplasms in adults. Their diagnosis and management constitute a challenging target. They originate from the mesenchyme, and 50 subtypes with various cytogenetic profiles concerning soft tissue and bones have been recognized. These tumors mainly affect middle-aged adults but may be present at any age. Half of the patients have metastatic disease at the time of diagnosis and require systemic therapy. Tumors above 3-5 cm in size must be suspected of potential malignancy...
February 24, 2023: World Journal of Clinical Oncology
https://read.qxmd.com/read/36907960/patterns-of-metastatic-recurrence-of-genetically-confirmed-myxoid-liposarcoma
#40
JOURNAL ARTICLE
Pauliina Homsy, Tom Böhling, Anne Seitsonen, Mika Sampo, Erkki Tukiainen, Carl Blomqvist
BACKGROUND: Most sarcomas metastasize predominantly to the lungs, and chest x-ray, or computed tomography, is the most commonly used staging investigation. Myxoid liposarcomas (MLSs) are rare tumors with a tendency to metastasize to extrapulmonary loci. The aim of this study was to assess the locations of the first metastases in MLS patients, to guide the design of effective staging and follow-up imaging protocols. METHODS: Patients treated for MLS between 1987 and 2017 were identified in a prospectively maintained register...
March 12, 2023: Annals of Surgical Oncology
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