keyword
Keywords Bone tumors, soft tissue tumor...

Bone tumors, soft tissue tumors , bone metastatic disease,

https://read.qxmd.com/read/38453159/carboplatin-in-patients-with-metastatic-castration-resistant-prostate-cancer-mcrpc-harbouring-somatic-or-germline-homologous-recombination-repair-hrr-gene-mutations-protocol-for-a-phase-ii-single-arm-trial
#1
JOURNAL ARTICLE
Rishabh Jain, Akash Kumar, Atul Sharma, Ranjit Kumar Sahoo, Aparna Sharma, Amlesh Seth, Brusabhanu Nayak, Shamim A Shamim, Seema Kaushal, Haresh Kp, Chandan J Das, Atul Batra
BACKGROUND: Metastatic castration-resistant prostate cancer (mCRPC) remains an unmet medical challenge. Approximately 20-25% of patients with mCRPC harbour a deleterious germline or somatic mutation in the homologous recombination repair (HRR) pathway genes, which is involved in the repair of double-stranded DNA damage. Half of these mutations are germline, while the remaining are exclusively somatic. While poly ADP ribose polymerase (PARP) inhibitors, like olaparib and rucaparib, are effective in this subgroup, their widespread use is limited due to the associated high cost, especially in resource-constrained settings...
March 6, 2024: JMIR Research Protocols
https://read.qxmd.com/read/38448852/the-effect-of-chemo-and-radiotherapy-on-tumor-necrosis-in-soft-tissue-sarcoma-does-it-influence-prognosis
#2
JOURNAL ARTICLE
Julian Fromm, Alexander Klein, Maya Kirilova, Lars Hartwin Lindner, Silke Nachbichler, Boris Michael Holzapfel, Sophia Samira Goller, Thomas Knösel, Hans Roland Dürr
BACKGROUND: Soft tissue sarcomas (STSs) are a heterogeneous group of tumors. Wide surgical resection is standard, often combined with neoadjuvant chemotherapy, radiotherapy, or both. Studies have shown the predictive value of tumor necrosis in bone sarcoma (BS); however, the role of necrosis in STS after neoadjuvant therapies is still unclear. This study aimed to investigate the role of chemo- and radiotherapy in the formation of tumor necrosis and to evaluate the influence of tumor necrosis on overall survival and local recurrence-free survival...
March 6, 2024: BMC Cancer
https://read.qxmd.com/read/38389212/renal-collision-tumor-a-case-of-small-cell-lung-cancer-metastasis-to-renal-angiomyolipoma
#3
JOURNAL ARTICLE
Aparna Singh, Hina J Shah, Borna E Dabiri, Wendy Landman
A 68-year-old woman presented with chest pain and shortness of breath. Imaging revealed a left hilar mass biopsy-proven as small cell cancer. Concurrently, a macroscopic fat-containing renal lesion consistent with an angiomyolipoma was observed. Systemic therapy achieved stability in the lungs and bones, and palliative radiation targeted the left hilum. However, progressive lung disease and brain metastases necessitated stereotactic radiosurgery for brain lesions. Notably, the renal angiomyolipoma exhibited increased soft tissue component and new focal uptake on FDG PET/CT...
February 23, 2024: Clinical Nuclear Medicine
https://read.qxmd.com/read/38369302/directional-microwave-ablation-in-spine-experimental-assessment-of-computational-modeling
#4
JOURNAL ARTICLE
Austin Pfannenstiel, Haileigh Avellar, Clay Hallman, Brandon L Plattner, Margaret A Highland, Francois H Cornelis, Warren L Beard, Punit Prakash
BACKGROUND: Despite the theoretical advantages of treating metastatic bone disease with microwave ablation (MWA), there are few reports characterizing microwave absorption and bioheat transfer in bone. This report describes a computational modeling-based approach to simulate directional microwave ablation (dMWA) in spine, supported by ex vivo and pilot in vivo experiments in porcine vertebral bodies. MATERIALS AND METHODS: A 3D computational model of microwave ablation within porcine vertebral bodies was developed...
2024: International Journal of Hyperthermia
https://read.qxmd.com/read/38351410/phosphaturic-mesenchymal-tumor-management-and-outcomes-of-ten-patients-treated-at-a-single-institution
#5
JOURNAL ARTICLE
Marcos R Gonzalez, Neel Patel, Joseph J Connolly, Yin P Hung, Connie Y Chang, Santiago A Lozano-Calderon
BACKGROUND: Phosphaturic mesenchymal tumor (PMT) is a rare tumor that causes tumor-induced osteomalacia. Patients present with non-specific symptoms secondary to renal phosphate wasting and decreased bone mineralization. We sought to assess: (1) What are the common presenting features, laboratory and imaging findings, histologic findings of phosphaturic mesenchymal tumors? (2) What are the available treatment strategies for phosphaturic mesenchymal tumors and their long-term outcomes in terms of local recurrence and symptom control after treatment? METHODS: We retrospectively identified patients with a histologic diagnosis of PMT located in the axial or appendicular skeleton, or surrounding soft tissues...
February 13, 2024: Skeletal Radiology
https://read.qxmd.com/read/38318175/tcr-transgenic-t-cells-and-yb-1-based-oncolytic-virotherapy-improve-survival-in-a-preclinical-ewing-sarcoma-xenograft-mouse-model
#6
JOURNAL ARTICLE
Sebastian J Schober, Melanie Thiede, Hendrik Gassmann, Anna Josefine von Ofen, Pia Knoch, Jennifer Eck, Carolin Prexler, Corazon Kordass-Wally, Julia Hauer, Stefan Burdach, Per Sonne Holm, Uwe Thiel
BACKGROUND: Ewing sarcoma (EwS) is an aggressive and highly metastatic bone and soft tissue tumor in pediatric patients and young adults. Cure rates are low when patients present with metastatic or relapsed disease. Therefore, innovative therapy approaches are urgently needed. Cellular- and oncolytic virus-based immunotherapies are on the rise for solid cancers. METHODS: Here, we assess the combination of EwS tumor-associated antigen CHM1319 -specific TCR-transgenic CD8+ T cells and the YB-1-driven (i...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38291358/when-the-second-comes-first-rhabdomyosarcoma-preceding-heritable-retinoblastoma-a-case-report
#7
JOURNAL ARTICLE
Devjyoti Tripathy, Alexandre Moulin, Jacques Bijon, Carole Gengler, Maja Beck-Popovic, Francis L Munier, Christina Stathopoulos
BACKGROUND: Retinoblastoma (rb) is the most frequent intraocular tumor, accounting for 3% of all childhood cancers. Heritable rb survivors are germline carriers for an RB1 mutation and have a lifelong risk to develop non-ocular second primary tumors (SPTs) involving multiple other organs like the bones, soft tissues, or skin. These SPTs usually become manifest several years succeeding the diagnosis of rb. In our instance, however, a non-ocular SPT presented prior to the diagnosis of heritable rb...
January 30, 2024: BMC Ophthalmology
https://read.qxmd.com/read/38254731/refusal-of-adjuvant-therapies-and-its-impact-on-local-control-and-survival-in-patients-with-bone-and-soft-tissue-sarcomas-of-the-extremities-and-trunk
#8
JOURNAL ARTICLE
Franziska Mentrup, Alexander Klein, Lars Hartwin Lindner, Silke Nachbichler, Boris Michael Holzapfel, Markus Albertsmeier, Thomas Knösel, Hans Roland Dürr
BACKGROUND: In soft tissue or bone sarcomas, multimodal therapeutic concepts represent the standard of care. Some patients reject the therapeutic recommendations due to several reasons. The aim of this study was to assess the impact of that rejection on both prognosis and local recurrence. METHODS: Between 2012 and 2019, a total of 828 sarcoma patients were surgically treated. Chemotherapy was scheduled as a neoadjuvant, and adjuvant multi-agent therapy was performed following recommendations from an interdisciplinary tumor board...
January 5, 2024: Cancers
https://read.qxmd.com/read/38233634/the-role-of-imaging-in-extremity-sarcoma-surgery
#9
REVIEW
Andrew J Kantzos, Laura M Fayad, Jad El Abiad, Shivani Ahlawat, Samir Sabharwal, Max Vaynrub, Carol D Morris
The surgical management of extremity bone and soft tissue sarcomas has evolved significantly over the last 50 years. The introduction and refinement of high-resolution cross-sectional imaging has allowed accurate assessment of anatomy and tumor extent, and in the current era more than 90% of patients can successfully undergo limb-salvage surgery. Advances in imaging have also revolutionized the clinician's ability to assess treatment response, detect metastatic disease, and perform intraoperative surgical navigation...
January 17, 2024: Skeletal Radiology
https://read.qxmd.com/read/38201600/imaging-grpr-expression-in-metastatic-castration-resistant-prostate-cancer-with-68-ga-ga-rm2-a-head-to-head-pilot-comparison-with-68-ga-ga-psma-11
#10
JOURNAL ARTICLE
René Fernández, Cristian Soza-Ried, Andrei Iagaru, Andrew Stephens, Andre Müller, Hanno Schieferstein, Camilo Sandoval, Horacio Amaral, Vasko Kramer
BACKGROUND: The gastrin-releasing peptide receptor (GRPr) is highly overexpressed in several solid tumors, including treatment-naïve and recurrent prostate cancer. [68 Ga]Ga-RM2 is a well-established radiotracer for PET imaging of GRPr, and [177 Lu]Lu-RM2 has been proposed as a therapeutic alternative for patients with heterogeneous and/or low expression of PSMA. In this study, we aimed to evaluate the expression of GRPr and PSMA in a group of patients diagnosed with castration-resistant prostate cancer (mCRPC) by means of PET imaging...
December 29, 2023: Cancers
https://read.qxmd.com/read/38189436/vascular-neoplasms-with-nfatc1-c2-gene-alterations-expanding-the-clinicopathologic-and-molecular-characteristics-of-a-distinct-entity
#11
JOURNAL ARTICLE
Nooshin K Dashti, Raul Perret, Bonnie Balzer, Rana Naous, Michael Michal, Josephine K Dermawan, Cristina R Antonescu
Despite significant advances in their molecular pathogenesis, skeletal vascular tumors remain diagnostically challenging due to their aggressive radiologic appearance and significant morphologic overlap. Within the epithelioid category and at the benign end of the spectrum, recurrent FOS/FOSB fusions have defined most epithelioid hemangiomas, distinguishing them from epithelioid hemangioendothelioma and angiosarcoma. More recently, the presence of EWSR1/FUS :: NFATC1/2 fusions emerged as the genetic hallmark of a novel group of unusual vascular proliferations, often displaying epithelioid morphology, with alternating vasoformative and solid growth, variable atypia, reminiscent of composite hemangioendothelioma...
April 1, 2024: American Journal of Surgical Pathology
https://read.qxmd.com/read/38107521/multiple-myeloma-following-bone-metastasis-of-renal-cell-carcinoma-a-case-report
#12
Hong Yu, Shengnan Zhang, Xiaohui Feng, Feng Gao
BACKGROUND: The clinical manifestations of multiple myeloma (MM) and bone metastatic tumor are both systemic bone pain, which is difficult to distinguish from imaging manifestations, leading to misdiagnosis and missed diagnosis. CASE SUMMARY: We reported a man with a unique case whose tumors were MM with bone metastatic tumor of clear cell renal cell carcinoma (CCRCC). Computed tomography (CT) showed multifocal osteolytic bone destruction, while magnetic resonance imaging (MRI) showed multifocal bone marrow infiltration with soft tissue mass...
2023: Frontiers in Endocrinology
https://read.qxmd.com/read/38105856/breast-ductal-infiltrative-adenocarcinoma-metastasis-to-the-mandible
#13
Paolo Boffano, Anna Maria Agnone, Ilenia Zanellato, Matteo Brucoli, Vincenzo Rocchetti
Metastatic lesions to the jaws are rare. The oral sites to which metastasis most commonly occur are the jaws, the gingiva, and the tongue. Lower jaw is a more frequent site of metastasis compared to the upper jaw with posterior areas (ramus, body) that are more prone to the deposition of cancerous cells due to presence of hematopoietic bone marrow, subdivision of local blood vessels and reduced velocity of blood flow. In fact, the formation of secondary foci of tumor colonization occurs by hematogenous dissemination of tumor emboli, that accumulate in regions with larger amounts of bone marrow and low circulatory velocity...
December 2023: Journal of Maxillofacial and Oral Surgery
https://read.qxmd.com/read/38054478/calcaneus-metastasis-a-rare-presentation-of-poorly-differentiated-thyroid-cancer
#14
JOURNAL ARTICLE
Omayma Elshafie, Anjali Jain, Summit Bichpuria, Yamina Rassou, Syed Furqan Hashmi, Abir Bou Khalil
SUMMARY: A 60-year-old woman presented to our clinic with an acute onset 3 months history of right ankle pain. The patient had a history of poorly differentiated thyroid cancer, which was treated with total thyroidectomy, left lateral neck dissection levels II-V and central neck dissection levels VI-VII followed by postoperative I-131 radioactive iodine (131I) ablation therapy 3.7 GBq 6 months ago. The post-131I WBS showed residual iodine-avid thyroid tissue with no other iodine-avid disease or metastasis...
October 1, 2023: Endocrinology, Diabetes & Metabolism Case Reports
https://read.qxmd.com/read/38031088/a-pilot-study-of-multi-antigen-stimulated-cell-therapy-i-plus-camrelizumab-and-apatinib-in-patients-with-advanced-bone-and-soft-tissue-sarcomas
#15
RANDOMIZED CONTROLLED TRIAL
Yan Zhou, Mei Li, Bing Zhang, Cheng Yang, Yaling Wang, Shuier Zheng, Lina Tang, Chenliang Zhou, Guowei Qian, Yujing Huang, Wenxi Yu, Hongtao Li, Yonggang Wang, Aina He, Zan Shen, Jianjun Zhang, Xiaoshuang Li, Qingcheng Yang, Haiyan Hu, Yang Yao
BACKGROUND: Cell-based  immunotherapy shows the therapeutic potential in sarcomas, in addition to angiogenesis-targeted tyrosine kinase inhibitor (TKI) and immune checkpoint inhibitor (ICI). Multi-antigen stimulated cell therapy-I (MASCT-I) technology is a sequential immune cell therapy for cancer, which composes of multiple antigen-loaded dendritic cell (DC) vaccines followed by the adoptive transfer of anti-tumor effector T-cells. METHODS: In this phase 1 study, we assessed MASCT-I plus camrelizumab (an ICI against PD-1) and apatinib (a highly selective TKI targeting VEGFR2) in patients with unresectable recurrent or metastatic bone and soft-tissue sarcoma after at least one line of prior systemic therapy...
November 29, 2023: BMC Medicine
https://read.qxmd.com/read/37958328/outcome-analysis-of-treatment-modalities-for-thoracic-sarcomas
#16
JOURNAL ARTICLE
Milos Sarvan, Harry Etienne, Lorenz Bankel, Michelle L Brown, Didier Schneiter, Isabelle Opitz
BACKGROUND: Primary chest wall sarcomas are a rare and heterogeneous group of chest wall tumors that require multimodal oncologic and surgical therapy. The aim of this study was to review our experience regarding the surgical treatment of chest wall sarcomas, evaluating the short- and long-term results. METHODS: In this retrospective single-center study, patients who underwent surgery for soft tissue and bone sarcoma of the chest wall between 1999 and 2018 were included...
October 26, 2023: Cancers
https://read.qxmd.com/read/37921888/-acetabular-metastatic-defect-reconstruction-using-the-modular-revision-support-cup-mrs-c
#17
REVIEW
S Koob, H Kohlhof, T M Randau, D C Wirtz
OBJECTIVE: Stabilization of metastatic acetabular defects with a bone cement-augmented revision support cup for remobilization of oncological patients in advanced cancer stages. INDICATIONS: Metastatic acetabular defects (Metastatic Acetabular Classification, MAC 2-4) in patients with a prognostic medium or long-term survival. CONTRAINDICATIONS: Highly limited survival due to metastatic disease (< 6 weeks). Local bone or soft tissue infection...
November 3, 2023: Operative Orthopädie und Traumatologie
https://read.qxmd.com/read/37894854/ews-fli1-characterization-activation-repression-target-genes-and-therapeutic-opportunities-in-ewing-sarcoma
#18
REVIEW
Muhammad Yasir, Jinyoung Park, Wanjoo Chun
Despite their clonal origins, tumors eventually develop into complex communities made up of phenotypically different cell subpopulations, according to mounting evidence. Tumor cell-intrinsic programming and signals from geographically and temporally changing microenvironments both contribute to this variability. Furthermore, the mutational load is typically lacking in childhood malignancies of adult cancers, and they still exhibit high cellular heterogeneity levels largely mediated by epigenetic mechanisms...
October 14, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37870280/relationship-between-metabolic-activity-cellularity-histopathological-features-of-primary-tumors-and-distant-metastatic-potential-in-breast-cancer
#19
JOURNAL ARTICLE
Uğuray Aydos, Seda Gülbahar Ateş, Osman Kurukahvecioğlu, Ümit Özgür Akdemir, Pınar Uyar Göçün, Lütfiye Özlem Atay
OBJECTIVES: The aim of this study was to evaluate the relationship between the types of distant metastatic spread, histopathological features, and imaging features of primary tumor on positron emission tomography/magnetic resonance imaging (PET/MRI) for primary staging in newly diagnosed breast invasive ductal carcinoma (IDC) patients. METHODS: Data from 289 female patients were retrospectively evaluated. Maximum standardized uptake value, metabolic tumor volume (MTV), total lesion glycolysis (TLG), and minimum apparent diffusion coefficient (ADCmin ) values of primary tumors were obtained from PET/MRI...
October 20, 2023: Molecular Imaging and Radionuclide Therapy
https://read.qxmd.com/read/37842554/immune-checkpoint-inhibitors-in-bone-metastasis-clinical-challenges-toxicities-and-mechanisms
#20
REVIEW
Gwenyth J Joseph, Douglas B Johnson, Rachelle W Johnson
Immune checkpoint inhibitors (ICIs) have revolutionized the field of anti-cancer therapy over the last decade; they provide durable clinical responses against tumors by inhibiting immune checkpoint proteins that canonically regulate the T cell-mediated immune response. Despite their success in many primary tumors and soft tissue metastases, ICIs function poorly in patients with bone metastases, and these patients do not have the same survival benefit as patients with the same primary tumor type (e.g., non-small cell lung cancer [NSCLC], urothelial, renal cell carcinoma [RCC], etc...
December 2023: Journal of Bone Oncology
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