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https://www.readbyqxmd.com/read/29150464/testosterone-therapy-in-hypogonadal-men-a-systematic-review-and-network-meta-analysis
#1
Jesse Elliott, Shannon E Kelly, Adam C Millar, Joan Peterson, Li Chen, Amy Johnston, Ahmed Kotb, Becky Skidmore, Zemin Bai, Muhammad Mamdani, George A Wells
OBJECTIVE: To assess the relative effects of individual testosterone products among hypogonadal men. DESIGN: Systematic review and network meta-analysis. METHODS: We searched MEDLINE, Embase, Cochrane CENTRAL, and grey literature (25 May 2017) for randomised-controlled trials (RCTs) and non-randomised studies (NRS) that involved hypogonadal men given testosterone replacement therapy (TRT) for ≥3 months. Comparators were placebo, another TRT, or the same product at a different dose...
November 16, 2017: BMJ Open
https://www.readbyqxmd.com/read/29105668/-testosterone-replacement-therapy-and-cardiovascular-risk
#2
Giovanni Corona, Mauro Dicuio, Giulia Rastrelli, Alessandra Sforza, Mario Maggi
Late onset hypogonadism (LOH) is the most commonly used term to indicate the age-dependent reduction of testosterone. Sexual dysfunction represents the most important determinant for medical consultation and the most specific symptoms associated with LOH. In particular, data from the European Male Ageing Study (EMAS), a population-based survey on more than 3400 subjects, recognized that a triad of sexual symptoms (low libido and reduced spontaneous and sex-related erections) is the only syndromic association with decreased testosterone levels...
November 2017: Giornale Italiano di Cardiologia
https://www.readbyqxmd.com/read/29100664/tyrosine-hydroxylase-in-the-ventral-tegmental-area-of-rams-with-high-or-low-libido-a-role-for-dopamine
#3
A C Kramer, A J Mirto, K J Austin, C E Roselli, B M Alexander
Dopamine synthesis in the ventral tegmental area (VTA) is necessary for the reinforcement of sexual behavior. The objective of this study determined if sexual stimuli initiates reward, and whether reward is attenuated in sexually inactive rams. Sexually active rams were exposed to urine from estrous (n=4) or ovariectomized (n=3) ewes with inactive rams (n=3) exposed to urine from estrous ewes. Following exposure, rams were exsanguinated and brains perfused. Alternating sections of the VTA were stained for Fos related antigens (FRA), tyrosine hydroxylase, and dopamine beta-hydroxylase activity...
October 31, 2017: Animal Reproduction Science
https://www.readbyqxmd.com/read/29095270/pituitary-insufficiency-following-traumatic-thoracic-injury-in-an-adolescent-male-patient-a-case-report-and-literature-review
#4
REVIEW
Aleksandra Gilis-Januszewska, Łukasz Kluczyński, Małgorzata Wilusz, Jacek Pantofliński, Renata Turek-Jabrocka, Dorota Pach, Alicja Hubalewska-Dydejczyk
RATIONALE: Traumatic thoracic injuries in adolescents are rare but could be connected with traumatic brain injuries (TBI) and development of chronic hypopituitarism. Early recognition of these endocrine problems is a significant challenge to clinicians. We present difficulties in diagnosis of hypothalamic-pituitary insufficiency following traumatic thoracic injury in adolescence. We also review the literature of similar cases. PATIENT CONCERNS: We present a case of a 24-years-old male...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29094914/testosterone-therapy-review-of-clinical-applications
#5
Ryan C Petering, Nathan A Brooks
Testosterone therapy is increasingly common in the United States, and many of these prescriptions are written by primary care physicians. There is conflicting evidence on the benefit of male testosterone therapy for age-related declines in testosterone. Physicians should not measure testosterone levels unless a patient has signs and symptoms of hypogonadism, such as loss of body hair, sexual dysfunction, hot flashes, or gynecomastia. Depressed mood, fatigue, decreased strength, and a decreased sense of vitality are less specific to male hypogonadism...
October 1, 2017: American Family Physician
https://www.readbyqxmd.com/read/29090093/effects-of-pituitary-specific-overexpression-of-fsh%C3%AE-%C3%AE-on-reproductive-traits-in-transgenic-boars
#6
Wenting Li, Yujun Quan, Mengmeng Zhang, Kejun Wang, Muzhen Zhu, Ye Chen, Qiuyan Li, Keliang Wu
BACKGROUND: Follicle-stimulating hormone (FSH) is a gonadotropin synthesized and secreted by the pituitary gland. FSH stimulates follicle development and maturation in females. It also plays an important role in spermatogenesis in males, including humans and mice. However, the effects of FSH on male pigs are largely unknown. In this study, we generated transgenic pigs to investigate the effects of FSHα/β overexpression on reproductive traits in boars. RESULTS: After five transgenic F0 founders were crossed with wide-type pigs, 193 F1 animals were obtained...
2017: Journal of Animal Science and Biotechnology
https://www.readbyqxmd.com/read/29076687/symptoms-of-menopause-in-peri-and-postmenopausal-women-and-their-attitude-towards-them
#7
Kausar Inayat, Nargis Danish, Lubna Hassan
BACKGROUND: The climacteric or perimenopause is the transitional phase during which reproductive function ceases. The average age of the menopause is 51.4 years with a duration of two years. Symptomatology include: vasomotor, psychological, urogenital/sexual, skin, menstrual irregularities and others. The objective was to study the attitude of these women towards menopause. METHODS: In this cross-sectional study, 500 women were included. RESULTS: Palpitations and headaches were found in 30% and 32% respectively in perimenopausal women compared to 16% and 20% in postmenopausal women...
July 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/29059347/sim1-neurons-are-sufficient-for-mc4r-mediated-sexual-function-in-male-mice
#8
Erin Semple, Jennifer W Hill
Sexual dysfunction is a poorly understood condition that affects up to one-third of men around the world. Existing treatments that target the periphery do not work for all men. Previous studies have shown that central melanocortins, which are released by pro-opiomelanocortin (POMC) neurons in the arcuate nucleus of the hypothalamus, can lead to male erection and increased libido. Several studies specifically implicate the melanocortin 4 receptor (MC4R) in the central control of sexual function, but the specific neural circuitry involved is unknown...
October 19, 2017: Endocrinology
https://www.readbyqxmd.com/read/29056645/fertility-lost-fertility-found-narratives-from-the-leading-edge-of-oncofertility
#9
Teresa K Woodruff
A cancer diagnosis at a young age creates one of the most existential crises one can imagine. The good news is that for many of these young patients, they will survive their diagnosis. They will be told of the side effects of treatment including loss of hair but will not be told of the other losses associated with their reproductive function-loss of menstrual cycles, early menopause and the potential for pregnancy for women, loss of viable sperm for men, and loss of sexual libido in both cases. Not all cancer treatments result in the same series of fertility effects so one of the issues that physicians face is determining what the best course of fertility sparing options should be...
2017: Narrative Inquiry in Bioethics
https://www.readbyqxmd.com/read/29036839/stroke-and-sexual-functioning-a-literature-review
#10
Anabelle Grenier-Genest, Marina Gérard, Frédérique Courtois
BACKGROUND: Stroke has multiple impacts on patients' sexual functioning, be it directly caused by the neurological lesion (s) or indirectly triggered via other psychophysiological processes. Despite a growing number of publications, sexuality is still rarely addressed in the stroke literature - yet, patients have indicated their need for sexual rehabilitation services. OBJECTIVE: To provide a literature review on post-stroke sexual functioning as well as available rehabilitation programs targeting patients' sexuality...
2017: NeuroRehabilitation
https://www.readbyqxmd.com/read/29034101/lamotrigine-induced-sexual-dysfunction-and-non-adherence-case-analysis-with-literature-review
#11
Kenneth R Kaufman, Melissa Coluccio, Kartik Sivaraaman, Miriam Campeas
BACKGROUND: Optimal anti-epileptic drug (AED) treatment maximises therapeutic response and minimises adverse effects (AEs). Key to therapeutic AED treatment is adherence. Non-adherence is often related to severity of AEs. Frequently, patients do not spontaneously report, and clinicians do not specifically query, critical AEs that lead to non-adherence, including sexual dysfunction. Sexual dysfunction prevalence in patients with epilepsy ranges from 40 to 70%, often related to AEDs, epilepsy or mood states...
September 2017: BJPsych Open
https://www.readbyqxmd.com/read/29020729/diagnosing-and-managing-androgen-deficiency-in-men
#12
REVIEW
Raveen Kaur Sandher, Jonathan Aning
Androgens play a crucial role in bone, muscle and fat metabolism, erythropoiesis and cognitive health. In men aged 40-79 years the incidence of biochemical deficiency and symptomatic hypogonadism is 2.1-5.7%. Decreased libido or reduced frequency and quality of erections, fatigue, irritability, infertility or a diminished feeling of wellbeing may be presenting complaints. However, a significant proportion of men with androgen deficiency will be identified when they present for unrelated concerns. Important factors to elicit from the history in addition to the presenting complaint include: a medical history of obesity, type 2 diabetes, systemic diseases or metabolic syndrome which all impact on testosterone physiology...
April 2017: Practitioner
https://www.readbyqxmd.com/read/29019272/amitriptyline-and-sexual-function-a-systematic-review-updated-for-sexual-health-practice
#13
Louis Wei-Hsi Chen, Melody Yun-Si Chen, Zhi-Ping Lian, Hung-Sheng Lin, Chia-Chang Chien, Hsin-Ling Yin, Yuan-Hsiang Chu, Kuo-Yen Chen
Amitriptyline is an old drug but is still prevalently used as the first-line treatment for a variety of common diseases. Surprisingly, knowledge of sexual risks with amitriptyline comes from only one clinical trial and several case reports from three decades ago. In the current study, a systematic review of the literature following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) related to amitriptyline and sexual dysfunction (SD) was performed. The frequency, gender-difference, types, disease-specificity and time course of SD, and the relationship between SD and nonsexual adversity were studied...
October 1, 2017: American Journal of Men's Health
https://www.readbyqxmd.com/read/28994489/short-term-resource-allocation-during-extensive-athletic-competition
#14
Daniel P Longman, Sean P Prall, Eric C Shattuck, Ian D Stephen, Jay T Stock, Jonathan C K Wells, Michael P Muehlenbein
OBJECTIVES: Following predictions from life history theory, we sought to identify acute trade-offs between reproductive effort (as measured by psychological arousal) and somatic maintenance (via functional measures of innate immunity) during conditions of severe energetic imbalance. METHODS: Sixty-six male ultramarathon runners (ages 20 to 37 years) were sampled before and after a lengthy race. Saliva and sera were collected for testosterone and immunological analyses (hemolytic complement activity and bacterial killing ability)...
October 10, 2017: American Journal of Human Biology: the Official Journal of the Human Biology Council
https://www.readbyqxmd.com/read/28924485/hypogonadotropic-hypogonadism-in-human-immunodeficiency-virus-infected-men-uncommonly-low-testosterone-levels
#15
Ana Coelho Gomes, José Maria Aragüés, Sílvia Guerra, Joana Fernandes, Mário Rui Mascarenhas
Hypogonadotropic hypogonadism (HH) is common and occurs prematurely in HIV-infected men. However, HH with very low testosterone has not been described. Three men with normal pubertal development and HIV1 diagnosis at the ages of 22, 34 and 35 years. All complained of decreased libido, anejaculation and erectile dysfunction thirteen years, six months and one year after HIV diagnosis, respectively. Two had depressive syndrome and two were treated with antiretroviral therapy. Laboratory tests revealed isolated HH in all...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/28913149/comparison-of-libido-female-sexual-function-index-and-arizona-scores-in-women-who-underwent-laparoscopic-or-conventional-abdominal-hysterectomy
#16
Semra Kayataş, Enis Özkaya, Murat Api, Seyhan Çıkman, Ayşen Gürbüz, Ahmet Eser
OBJECTIVE: The aim of the present study was to compare female sexual function between women who underwent conventional abdominal or laparoscopic hysterectomy. MATERIALS AND METHODS: Seventy-seven women who were scheduled to undergo hysterectomy without oophorectomy for benign gynecologic conditions were included in the study. The women were assigned to laparoscopic or open abdominal hysterectomy according to the surgeons preference. Women with endometriosis and symptomatic prolapsus were excluded...
June 2017: Turk J Obstet Gynecol
https://www.readbyqxmd.com/read/28883919/a-case-of-klinefelter-syndrome-with-hypersexual-desire
#17
Kingsley Okolie, Sumathy Perampalam, Anthony Barker, Christopher J Nolan
Klinefelter syndrome (KS) is a chromosomal disorder affecting males, with the typical karyotype of 47,XXY due to a supernumerary X chromosome, which causes progressive testicular failure resulting in androgen deficiency and infertility. Despite it being the most common sex chromosomal disorder, its diagnosis is easily missed. In addition to its classical clinical features of tall stature, gynaecomastia, small testes, and symptoms and signs of hypogonadism including infertility, KS is also often associated with neurocognitive, behavioural and psychiatric disorders...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/28843181/early-prenatal-androgen-exposure-reduces-testes-size-and-sperm-concentration-in-sheep-without-altering-neuroendocrine-differentiation-and-masculine-sexual-behavior
#18
C M Scully, C T Estill, R Amodei, A McKune, K P Gribbin, M Meaker, F Stormshak, C E Roselli
Prenatal androgens are largely responsible for growth and differentiation of the genital tract and testis and for organization of the control mechanisms regulating male reproductive physiology and behavior. The aim of the present study was to evaluate the impact of inappropriate exposure to excess testosterone (T) during the first trimester of fetal development on the reproductive function, sexual behavior, and fertility potential of rams. We found that biweekly maternal T propionate (100 mg) treatment administered from Day 30-58 of gestation significantly decreased (P < 0...
July 29, 2017: Domestic Animal Endocrinology
https://www.readbyqxmd.com/read/28831925/diabetes-mellitus-and-male-aging-pharmacotherapeutics-and-clinical-implications
#19
Swathi Putta, Ilaria Peluso, Nagendra Sastry Yarla, Eswar Kumar Kilari, Anupam Bishayee, Da-Yong Lu, George E Barreto, Ghulam Md Ashraf, Luciana Scotti, Marcus T Scotti, Rajeev K Singla, Thonos Alexiou, Atanas G Atanasov, Vadim V Tarasov, P Veera Bramhachari, Sarat Babu Imandi, Madhuri Chintala, Bechan Sharma, Marcella Reale, Rosanna Filosa, Gjumrakch Aliev, Mohammad Amjad Kamal
Andropause or male menopause is defined as androgen decline and onset of hypogonadism in the aging male. Testosterone deficiency in adult male is associated with diabetes mellitus, coronary artery disease, and heart failure. Type 2 diabetic male patients aged above 30 years showed low testosterone levels which is common in diabetic men and had symptoms of hypogonadism. Male sexual dysfunction among diabetic patients can include disorders of libido, ejaculatory problems, and erectile dysfunctions are common among people with diabetes, particularly in older men who had diabetes for years...
August 22, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28817869/re-impact-of-combination-therapy-5-alpha-reductase-inhibitors-5-ari-plus-alpha-blockers-ab-on-erectile-dysfunction-and-decrease-of-libido-in-patients-with-luts-bph-a-systematic-review-with-meta-analysis
#20
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