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https://www.readbyqxmd.com/read/28434676/meta-analysis-of-results-of-testosterone-therapy-on-sexual-function-based-on-international-index-of-erectile-function-scores
#1
Giovanni Corona, Giulia Rastrelli, Abraham Morgentaler, Alessandra Sforza, Edoardo Mannucci, Mario Maggi
CONTEXT: The interpretation of available clinical evidence related to the effect of testosterone (T) treatment (TTh) on sexual function has been inconsistent, in part due to the use of different and self-reported measures to assess outcomes. The International Index of Erectile Function (IIEF) is the most frequently used validated tool to assess male sexual function. OBJECTIVE: To perform a meta-analysis of available data evaluating the effect of TTh on male sexual function using IIEF as the primary outcome...
April 20, 2017: European Urology
https://www.readbyqxmd.com/read/28389219/somatic-effects-of-aas-abuse-a-30-years-follow-up-study-of-male-former-power-sports-athletes
#2
A S Lindqvist Bagge, T Rosén, C Fahlke, C Ehrnborg, B O Eriksson, T Moberg, I Thiblin
OBJECTIVES: The aim of the present study was to investigate the association between somatic health and former abuse of AAS in former elite male athletes 30 years after the end of their active sports career. DESIGN: Retrospective follow-up study. METHODS: N=996 former elite male athletes were sent a questionnaire concerning sociodemographic variables, previous and past sport activity and lifetime prevalence of seeking professional help for health problems...
March 21, 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/28382300/male-sexual-dysfunction-and-chronic-kidney-disease
#3
REVIEW
Matthew M Edey
Male sexual dysfunction is common in chronic kidney disease (CKD), particularly in end-stage renal disease. Historically, this cause of considerable morbidity has been under-reported and under-recognized. The ideal approach to diagnosis and management remains unclear due to a paucity of good quality data, but an understanding of the pathophysiology is necessary in order to address the burden of this important complication of CKD. This paper will review the endocrine dysfunction that occurs in renal disease, particularly the hypothalamic-pituitary-gonadal axis, discuss the causes of erectile dysfunction, infertility, and altered body image and libido in these patients and suggest appropriate treatment interventions...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/28367782/an-automated-method-for-the-evaluation-of-ram-libido-in-real-mating-conditions
#4
M Alhamada, N Debus, F Bocquier
We investigated if sexual behaviour of rams can be assessed with an electronic Alpha-Detector (AD) which automatically records mounts of mating rams. To evaluate the rams' libido (i.e. all sexual activities), we used six intact and six vasectomised rams in pen tests in three different seasons (late spring, autumn and early spring). The pen tests consisted of 30-min visual observations of each ram placed in a group of six Merino ewes (three ewes in oestrus and three ewes not in oestrus). In the pen tests, sexual behaviour was recorded and divided into two categories: pre-copulatory and copulatory...
April 3, 2017: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/28366111/safety-of-treatments-for-adhd-in-adults-pairwise-and-network-meta-analyses
#5
Danielly Chierrito de Oliveira, Patricia Guerrero de Sousa, Camila Borges Dos Reis, Fernanda Stumpf Tonin, Laiza Maria Steimbach, Suzane Virtuoso, Fernando Fernandez-Llimos, Roberto Pontarolo, Andréia Cristina Conegero Sanches
OBJECTIVE: The aim of the study was to analyze evidence comparing the profile of drugs used to treat ADHD in adult patients. METHOD: Systematic searches were conducted in electronic databases. Randomized, double-blind, parallel controlled trials that evaluated the safety of drugs in ADHD were included. The statistical analyses were conducted by pairwise meta-analyses and mixed treatment comparison (MTC). RESULTS: Ten ( n = 3006) trials were included in the analyses...
March 1, 2017: Journal of Attention Disorders
https://www.readbyqxmd.com/read/28363129/severe-camphor-poisoning-a-seven-year-observational-study
#6
Mitra Rahimi, Fatemeh Shokri, Hossein Hassanian-Moghaddam, Nasim Zamani, Abdolkarim Pajoumand, Shahin Shadnia
In a retrospective case series from 2007 to 2014, we searched for any accidental/intentional, and recreational cases of pure camphor poisoning through hospital records. Epidemiological data, as well as factors correlated with seizure, were evaluated. Thirty cases including 29 males were recruited with a median age of 18 years (range; 0.2-87). Patient's reported ingestion rate of camphor was 1.5-15 grams. Almost all of the patients (96.7%) were conscious on arrival time and the ingestion to the presentation time ratio was 7±5h...
March 21, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28336184/atrial-fibrillation-management-in-a-breeding-stallion
#7
N Heliczer, K Mitchell, O Lorello, J Dauvillier, D Burger, C C Schwarzwald, C Navas de Solis
A 20-year-old warmblood breeding stallion presented to a University practice for semen collection and evaluation was incidentally diagnosed with atrial fibrillation (AF). Electrocardiogram recordings during breeding revealed inappropriately rapid tachycardia and occasional ventricular premature depolarizations/aberrant ventricular conduction. Transvenous electrical cardioversion was performed. After successful cardioversion the horse displayed supraventricular ectopy and atrial contractile dysfunction and was administered sotalol hydrochloride in an attempt to decrease the risk of AF recurrence...
March 20, 2017: Journal of Veterinary Cardiology: the Official Journal of the European Society of Veterinary Cardiology
https://www.readbyqxmd.com/read/28333842/review-article-sexuality-and-risk-reducing-salpingo-oophorectomy
#8
Paige E Tucker, Paul A Cohen
INTRODUCTION: Women with familial cancer syndromes such as hereditary breast and ovarian cancer syndrome (BRCA1 and BRCA2) and Lynch syndrome are at a significantly increased risk of developing ovarian cancer and are advised to undergo prophylactic removal of their ovaries and fallopian tubes at age 35 to 40 years, after childbearing is complete. METHODS: A comprehensive literature search of studies on risk-reducing salpingo-oophorectomy (RRSO), sexuality, and associated issues was conducted in MEDLINE databases...
May 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28333214/-forever-young-%C3%A2-testosterone-replacement-therapy-a-blockbuster-drug-despite-flabby-evidence-and-broken-promises
#9
Andrea Busnelli, Edgardo Somigliana, Paolo Vercellini
In the last decade, testosterone replacement therapy (TRT) has been increasingly prescribed to treat a controversial condition known as 'late-onset hypogonadism (LOH)'. This syndrome is diagnosed in men who, for no discernible reason other than older age, obesity or ill health have serum testosterone concentrations below the normal range for healthy young men and report one or more of the following symptoms: muscle weakness or wasting, mood, behaviour and cognition-related symptoms and sexual function or libido impairment...
April 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28291031/a-sex-specific-dose-response-curve-for-testosterone-could-excessive-testosterone-limit-sexual-interaction-in-women
#10
Jill M Krapf, James A Simon
Testosterone treatment increases sexual desire and well-being in women with hypoactive sexual desire disorder; however, many studies have shown only modest benefits limited to moderate doses. Unlike men, available data indicate women show a bell-shaped dose-response curve for testosterone, wherein a threshold dosage of testosterone leads to desirable sexual function effects, but exceeding this threshold results in a lack of further positive sexual effects or may have a negative impact. Emotional and physical side-effects of excess testosterone, including aggression and virilization, may counteract the modest benefits on sexual interaction, providing a possible explanation for a threshold dose of testosterone in women...
April 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28289563/persistent-erectile-dysfunction-in-men-exposed-to-the-5%C3%AE-reductase-inhibitors-finasteride-or-dutasteride
#11
Tina Kiguradze, William H Temps, Paul R Yarnold, John Cashy, Robert E Brannigan, Beatrice Nardone, Giuseppe Micali, Dennis Paul West, Steven M Belknap
IMPORTANCE: Case reports describe persistent erectile dysfunction (PED) associated with exposure to 5α-reductase inhibitors (5α-RIs). Clinical trial reports and the manufacturers' full prescribing information (FPI) for finasteride and dutasteride state that risk of sexual adverse effects is not increased by longer duration of 5α-RI exposure and that sexual adverse effects of 5α-RIs resolve in men who discontinue exposure. OBJECTIVE: Our chief objective was to assess whether longer duration of 5α-RI exposure increases risk of PED, independent of age and other known risk factors...
2017: PeerJ
https://www.readbyqxmd.com/read/28288664/injured-bodies-damaged-lives-experiences-and-narratives-of-kenyan-women-with-obstetric-fistula-and-female-genital-mutilation-cutting
#12
Lillian Mwanri, Glory Joy Gatwiri
BACKGROUND: It is well acknowledged that Female Genital Mutilation/Cutting (FGM/C/C) leads to medical, psychological and sociocultural sequels. Over 200 million cases of FGM/C exist globally, and in Kenya alone, a total of 12,418,000 (28%) of women have undergone FGM/C, making the practice not only a significant national, but also a global health catastrophe. FGM/C is rooted in patriarchal and traditional cultures as a communal experience signifying a transition from girlhood to womanhood...
March 14, 2017: Reproductive Health
https://www.readbyqxmd.com/read/28285412/symptoms-and-impacts-in-non-metastatic-castration-resistant-prostate-cancer-qualitative-study-findings
#13
Erin L Tomaszewski, Pierre Moise, Robert N Krupnick, Jared Downing, Margaret Meyer, Shevani Naidoo, Stefan Holmstrom
OBJECTIVES: We developed a conceptual model to define key concepts associated with patients' experiences with the signs, symptoms, and impacts of non-metastatic castration-resistant prostate cancer (M0-CRPC). METHODS: A targeted review of peer-reviewed literature, and other publicly available information, identified and categorized symptoms and impacts related to early-stage prostate cancer. Semi-structured interviews with five clinical experts helped determine the most relevant and important concepts for patients with M0-CRPC...
March 11, 2017: Patient
https://www.readbyqxmd.com/read/28284776/neural-underpinnings-of-prosexual-effects-induced-by-gamma-hydroxybutyrate-in-healthy-male-humans
#14
Oliver G Bosch, Michael M Havranek, Andrea Baumberger, Katrin H Preller, Robin von Rotz, Marcus Herdener, Rainer Kraehenmann, Philipp Staempfli, Milan Scheidegger, Tim Klucken, Erich Seifritz, Boris B Quednow
Gamma-hydroxybutyrate (GHB) is a GHB-/GABAB-receptor agonist currently used as treatment for narcolepsy but also as a drug of abuse. Non-medical GHB users have repeatedly reported prosexual effects including libido-enhancement and lowering of attractiveness standards for partner selection. Here, we examined the putative prosexual effects of oral GHB in healthy males in two experiments both employing randomized, placebo-controlled, double-blind, balanced, and cross-over study designs. In experiment I, subjective effects of 20 and 35mg/kg GHB vs...
March 8, 2017: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28275020/intellectual-disability-complicated-by-sexual-addiction-an-uncommon-presentation-of-a-common-condition
#15
Nicholas Tze Ping Pang, Ruziana Masiran
A young man presented with high libido for 3 years, associated with preoccupation with sexual thoughts combined with his pursuit of pornographic materials. He had strong psychological cravings for and had spent large amount of money on sex, resulting in a dispute with his family. There were no mood or psychotic symptoms. Medical history revealed recent diagnosis of gonococcal urethritis. Cognitive assessment showed subtle deficiencies in reasoning and executive functions. There was occasional use of alcohol...
March 8, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28271984/need-for-desire-drugs-debated
#16
Jan Greene
Some see a big market for medications for low libido in women. But sales of Addyi have been slow. Has a normal experience been unnecessarily medicalized? One of many factors in the debate is whether women#x02019;s sexual response tends to be more spontaneous or responsive.
February 2017: Managed Care
https://www.readbyqxmd.com/read/28262100/sexual-rehabilitation-after-treatment-for-prostate-cancer-part-2-recommendations-from-the-fourth-international-consultation-for-sexual-medicine-icsm-2015
#17
Andrea Salonia, Ganesh Adaikan, Jacques Buvat, Serge Carrier, Amr El-Meliegy, Kostas Hatzimouratidis, Andrew McCullough, Abraham Morgentaler, Luiz Otavio Torres, Mohit Khera
INTRODUCTION: Sexual dysfunction is common in patients after radical prostatectomy (RP) for prostate cancer. AIM: To provide the International Consultation for Sexual Medicine (ICSM) 2015 recommendations concerning management strategies for post-RP erectile function impairment and to analyze post-RP sexual dysfunction other than erectile dysfunction. METHODS: A literature search was performed using Google and PubMed database for English-language original and review articles published up to August 2016...
March 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28261826/a-literature-review-of-antithrombotic-and-anticoagulating-agents-on-sexual-function
#18
L W-H Chen, H-L Yin
Although millions of people receive antithrombotic agents (ATAs) or anticoagulating agents (ACAs) for vascular prophylaxis daily, the negative impact of these agents on sexual function has not been systematically studied. Therefore, a literature search was conducted to determine the effects of the marketed ATAs and ACAs on sexual function. In regard to men, the results show that thienopyridine derivatives increase the risk of erectile dysfunction (ED) and decrease libido and sexual function. The relationship between aspirin use and ED is inconsistent, ranging from a moderate risk to beneficial effects...
March 6, 2017: Andrologia
https://www.readbyqxmd.com/read/28259255/eurycoma-longifolia-as-a-potential-adoptogen-of-male-sexual-health-a-systematic-review-on-clinical-studies
#19
REVIEW
Hnin Ei Thu, Isa Naina Mohamed, Zahid Hussain, Putri Ayu Jayusman, Ahmad Nazrun Shuid
Eurycoma longifolia (EL) has been well recognized as a booster of male sexual health. Over the past few decades, numerous in vivo animal studies and human clinical trials have been conducted across the globe to explore the promising role of EL in managing various male sexual disorders, which include erectile dysfunction, male infertility, low libido, and downregulated testosterone levels. The aim of the present review is to analyze and summarize the literature on human clinical trials which revealed the clinical significance and therapeutic feasibility of EL in improving male sexual health...
January 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/28257869/calving-distributions-of-individual-bulls-in-multiple-sire-pastures
#20
Kaitlynn M Abell, Miles E Theurer, Robert L Larson, Brad J White, David K Hardin, Richard F Randle, Robert A Cushman
The objective of this project was to quantify patterns in the calving rate of sires in multiple-sire pastures over seven years at a large-scale cow-calf operation. Data consisted of reproductive and genomic records from multiple-sire breeding pastures (n = 33) at the United States Meat Animal Research Center (USMARC) from 2007 to 2013. Calving intervals were analyzed in 21-day periods. A ranking system for each bull was developed based on the calving rate per pasture over the breeding season, with Rank 1 = the bull with greatest calving rate, Rank 3 = the bull with the least calving rate, and Rank 2 = all other bulls...
April 15, 2017: Theriogenology
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