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https://www.readbyqxmd.com/read/29333902/patterns-of-nps-use-and-risk-reduction-in-slovenia
#1
Matej Sande, Mina Paš, Klara Nahtigal, Simona Šabić
BACKGROUND: The following study presents factors influencing the decision to use/not to use new psychoactive substances (NPS), various patterns of NPS use, the problems experienced by users, and the methods for reducing the risks associated with NPS use. OBJECTIVES: The study seeks to provide an in-depth look into the characteristics of NPS use and support the planning of targeted interventions in the field of NPS. METHODS: The study involved 19 in-depth interviews carried out with 25 individuals divided into three subsamples in order to gain insight into the various experiences of NPS users...
January 15, 2018: Substance Use & Misuse
https://www.readbyqxmd.com/read/29330444/lidocaine-enhances-the-effects-of-chemotherapeutic-drugs-against-bladder-cancer
#2
Xihua Yang, Lili Zhao, Meiping Li, Lei Yan, Shengwan Zhang, Zhenguo Mi, Liansheng Ren, Jun Xu
This study aimed to investigate whether lidocaine, alone or in combination with other chemotherapeutic agents, inhibits the growth of human bladder cancer cells in vitro and orthotopically transplanted bladder tumors in vivo. The effects of lidocaine (1.25, 2.5 or 5 mg/mL), mitomycin C (MMC, 0.66 mg/mL), pirarubicin (0.75 mg/mL) and Su Fu'ning lotion (SFN, 0.0625 mg/mL) on the proliferation of human bladder cancer (BIU-87) cells were studied using the MTT assay. A Balb/c nude mouse model of bladder cancer was developed by orthotopic transplantation of BIU-87 cells, and the effects of intravesical instillation of lidocaine and MMC on bladder wet weight (a measure of tumor size) and survival (over 60 days) were studied...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29316543/the-use-of-external-ventricular-drainage-to-reduce-the-frequency-of-wound-complications-in-myelomeningocele-closure
#3
Michael M McDowell, Philip S Lee, Kimberly A Foster, Stephanie Greene
INTRODUCTION: Myelomeningocele (MMC) is an open neural tube defect routinely surgically closed within 48 h of birth to prevent secondary infection. Up to 18% of patients experience wound complications, and 85% require shunting for hydrocephalus. We hypothesized that wound complications could be reduced by cerebrospinal fluid (CSF) diversion at the time of closure. METHODS: Institutional review board approval was obtained to review records of the 88 patients who underwent MMC closure between January 2005 and June 2016 at the Children's Hospital of Pittsburgh...
January 10, 2018: Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29315438/femtosecond-laser-assisted-lasik-with-and-without-the-adjuvant-use-of-mitomycin-c-to-correct-hyperopia
#4
Montserrat Garcia-Gonzalez, MariLuz Iglesias-Iglesias, Pilar Drake Rodriguez-Casanova, Juan Gros-Otero, Miguel A Teus
PURPOSE: To compare the visual and refractive results of femtosecond laser-assisted LASIK (FS-LASIK) with and without the adjuvant use of mitomycin C (MMC) to correct hyperopia. METHODS: A total of 152 consecutive hyperopic eyes were included in this retrospective, observational cohort study, comparing 76 eyes treated with FS-LASIK + MMC with 76 age- and refraction-matched eyes treated with FS-LASIK without MMC. Visual and refractive results were evaluated 1 day, 1 week, and 1, 3, 6, and 15 months postoperatively...
January 1, 2018: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/29307447/microvascular-mural-cell-organotypic-heterogeneity-and-functional-plasticity
#5
REVIEW
Annegret Holm, Tina Heumann, Hellmut G Augustin
Microvascular mural cells (MMCs), comprising pericytes and microvascular smooth muscle cells, are of increasing interest in multiple fields of research for their plasticity and their organotypic functional roles in microvascular homeostasis and disease. They have been described as a heterogeneous cell population constituting a continuum of cell phenotypes along the microvascular bed with vascular smooth muscle cells (VSMCs) at one end of the spectrum and pericytes at the other end. MMC organotypic subpopulations have been suggested to function in a tissue-context-dependent manner, thereby contributing to organ-specific functional roles...
January 4, 2018: Trends in Cell Biology
https://www.readbyqxmd.com/read/29307285/incidence-of-fanconi-anaemia-in-phenotypically-normal-aplastic-anaemia-patients-in-west-bengal
#6
Atreyee Dutta, Rajib De, Tuphan Kanti Dolai, Pritha Pal, Shanoli Ghosh, Pradip Kumar Mitra, Ajanta Halder
OBJECTIVES: Fanconi anaemia (FA) is a rare inherited bone marrow failure and autosomal recessive blood disorder. FA patients have a higher risk of cancer, including acute myeloid leukaemia and squamous cell carcinoma. Maximum, but not all, affected individuals have one or more somatic abnormalities, including skin, skeletal, genitourinary, gastrointestinal, cardiac and neurological anomalies, etc. Positive stress cytogenetics has immense implications for the treatment and management of FA...
January 7, 2018: Hematology (Amsterdam, Netherlands)
https://www.readbyqxmd.com/read/29306635/a-mixed-mode-chromatographic-separation-method-for-the-analysis-of-dialkyl-phosphates
#7
Shaogang Chu, Robert J Letcher
While reversed-phase (RP) liquid chromatography can separate a wide range of analytes, for strongly acidic compounds such as environmentally relevant dialkyl phosphates (DAPs), this remains a challenge because they have low affinity for standard RP columns or they exhibit inferior peak shapes. Mixed-mode chromatographic (MMC) columns, which contain both RP and ion-exchange functionalities, can address these resolution problems. However, using current MMC separation approaches, analyte peaks are relatively broad as compared to conventional RP chromatography...
January 2, 2018: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29303888/systemic-absorption-of-mitomycin-c-when-used-in-pterygium-surgery
#8
Michael Yulish, Ahmed Khatib, Joseph Pikkel
PURPOSE: To determine whether scleral topical application of mitomycin-C (MMC) results in measurable plasma levels of systemic absorption. METHODS: The study comprised 27 patients who were treated with MMC 0.2 mg/mL (0.02%) for 60 seconds during pterygium surgery. Blood samples were taken 30 minutes after surgery and evaluated by the human plasma liquid chromatography tandem-mass spectrometry method to determine the presence of MMC. RESULTS: The amount of MMC in 27 samples tested was determined as below 0...
January 4, 2018: Cornea
https://www.readbyqxmd.com/read/29302380/a-case-of-fatal-pulmonary-hypoplasia-with-congenital-diaphragmatic-hernia-thoracic-myelomeningocele-and-thoracic-dysplasia
#9
Ai Ito, Hideshi Fujinaga, Sachiko Matsui, Kumiko Tago, Yuka Iwasaki, Shuhei Fujino, Junko Nagasawa, Shoichiro Amari, Masao Kaneshige, Yuka Wada, Shigehiro Takahashi, Keiko Tsukamoto, Osamu Miyazaki, Takako Yoshioka, Akira Ishiguro, Yushi Ito
Background  Congenital diaphragmatic hernia (CDH) is fatal in severe cases of pulmonary hypoplasia. We experienced a fatal case of pulmonary hypoplasia due to CDH, thoracic myelomeningocele (MMC), and thoracic dysplasia. This constellation of anomalies has not been previously reported. Case Report  A male infant with a prenatal diagnosis of thoracic MMC with severe hydrocephalus and scoliosis was born at 36 weeks of gestation. CDH was found after birth and the patient died of respiratory failure due to pulmonary hypoplasia and persistent pulmonary hypertension of the newborn at 30 hours of age despite neonatal intensive care...
October 2017: American Journal of Perinatology Reports
https://www.readbyqxmd.com/read/29288215/klu-suppresses-megasporocyte-cell-fate-through-swr1-mediated-activation-of-wrky28-expression-in-arabidopsis
#10
Lihua Zhao, Hanyang Cai, Zhenxia Su, Lulu Wang, Xinyu Huang, Man Zhang, Piaojuan Chen, Xiaozhuan Dai, Heming Zhao, Ravishankar Palanivelu, Xuemei Chen, Yuan Qin
Germ-line specification is essential for sexual reproduction. In the ovules of most flowering plants, only a single hypodermal cell enlarges and differentiates into a megaspore mother cell (MMC), the founder cell of the female germ-line lineage. The molecular mechanisms restricting MMC specification to a single cell remain elusive. We show that the Arabidopsis transcription factor WRKY28 is exclusively expressed in hypodermal somatic cells surrounding the MMC and is required to repress these cells from acquiring MMC-like cell identity...
December 29, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29286884/antigenotoxicity-properties-of-copaifera-multijuga-oleoresin-and-its-chemical-marker-the-diterpene-copalic-acid
#11
Jacqueline Morais Alves, Luís Fernando Leandro, Juliana Marques Senedese, Pâmela Tinti de Castro, Daiane Eleutério Pereira, Flávia Aparecida Resende, Débora Leite Campos, Jonas Joaquim Mangabeira da Silva, Eliana Aparecida Varanda, Jairo Kenupp Bastos, Sérgio Ricardo Ambrósio, Denise Crispim Tavares
In view of the biological activities and growing therapeutic interest in oleoresin obtained from Copaifera multijuga, this study aimed to determine the genotoxic and antigenotoxic potential of this oleoresin (CMO) and its chemical marker, diterpene (-)-copalic acid (CA). The micronucleus (MN) assay in V79 cell cultures and the Ames test were used for in vitro analyses, as well as MN and comet assays in Swiss mice for in vivo analyses. The in vitro genotoxicity/mutagenicity results showed that either CMO (30, 60, or 120 µg/ml-MN assay; 0...
December 29, 2017: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/29283419/aluminum-matrix-composite-alsi7mg2sr0-03-sicp-pistons-obtained-by-mechanical-mixing-method
#12
Maciej Dyzia
Metal matrix composites are undoubtedly a group of advanced engineering materials. Compared to unreinforced matrix material, they are characterized by increased strength, greater stiffness, increased wear resistance, better mechanical properties and dimensional stability at elevated temperatures as well as lower density. Due to its very favorable tribological properties for many years research has been conducted on the application of MMC in friction node. The article presents important technological aspects related to the production and properties of composite pistons...
December 28, 2017: Materials
https://www.readbyqxmd.com/read/29283127/rescue-of-failing-or-failed-trabeculectomy-blebs-with-slit-lamp-needling-and-adjunctive-mitomycin-c-in-indian-eyes
#13
Vanita Pathak-Ray, Nikhil Choudhari
PURPOSE: The aim of this study is to investigate the efficacy and safety of needling-revision augmented with a high dose of mitomycin C (MMC) in failing or failed blebs after trabeculectomy in Indian eyes. METHODS: Prospective, noncomparative, interventional study. All patients (>18 years) who had raised intraocular pressure (IOP) following trabeculectomy (>6 weeks and <2 years), who had a flat bleb, bleb encapsulation, and/or required antiglaucoma medication (AGM) for IOP control were eligible for inclusion...
January 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29283126/comparison-of-surgical-outcomes-between-canaloplasty-and-trabeculectomy-with-mitomycin-c-at-2-year-follow-up-a-longitudinal-cohort-study
#14
Winston J Garris, Crystal Le, David Zurakowski, Ramesh S Ayyala
PURPOSE: To compare operative outcomes of patients after canaloplasty and trabeculectomy with mitomycin C (MMC) through 2-year follow-up. METHODS: We included 31 eyes of 31 patients with primary open-angle glaucoma (POAG) who underwent canaloplasty and 37 eyes of 37 patients with POAG who underwent trabeculectomy with MMC with 24 months of postoperative follow-up. All surgeries were performed by a single surgeon between January 2005 and May 2011. Failure was defined as intraocular pressure (IOP> 18 or <4 mmHg at 2 years), second operative procedure, or loss of light perception...
January 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29281929/protective-effect-of-aspirin-against-mitomycin-c-induced-carcinogenicity-assessed-by-the-test-for-detection-of-epithelial-tumor-clones-warts-in-drosophila-melanogaster
#15
Victor Constante Oliveira, Sarah Alves Rodrigues Constante, Lorena Polloni, Priscila Capelari Orsolin, Rosiane Gomes Silva-Oliveira, Nayane Moreira Machado, Robson José de Oliveira-Júnior, Júlio César Nepomuceno
The present study assessed the protective effect of aspirin against carcinogenicity induced by mitomycin C (MMC) by the test for detection of warts/epithelial tumor clones in Drosophila melanogaster. Larvae were treated with different concentrations of aspirin alone (10, 20 or 40 mg/mL) or aspirin in association with MMC. MMC and ultrapure water were employed as the positive and negative control, respectively. Antioxidant activity was determined using the DPPH method. For performing cytotoxicity assay on HeLa cells, the aspirin concentrations used ranged from 200 mmol/L to 3,125 mmol/L...
December 27, 2017: Drug and Chemical Toxicology
https://www.readbyqxmd.com/read/29278735/expanding-the-fanco-rad51c-associated-phenotype-cleft-lip-and-palate-and-lobar-holoprosencephaly-two-rare-findings-in-fanconi-anemia
#16
Adeline Jacquinet, Lindsay Brown, Jessica Sawkins, Pengfei Liu, Denise Pugash, Margot I Van Allen, Millan S Patel
Fanconi anemia is a rare chromosome instability disorder with a highly variable phenotype. In the antenatal and neonatal periods, the diagnosis is usually suggested by the presence of typical congenital abnormalities such as intrauterine growth retardation, microcephaly and radial ray defects. We report a newborn female with a prenatal diagnosis of Fanconi anemia, complementation group O (FANCO). Antenatal ultrasounds identified symmetrical intrauterine growth retardation, complex heart defect as well as brain anomalies, overlapping fingers and cleft lip and palate...
December 23, 2017: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/29274020/short-term-change-in-higher-order-aberrations-after-mitomycin-c-augmented-trabeculectomy
#17
Seong Ho Jo, Je Hyun Seo
PURPOSE: To investigate the changes in ocular higher-order aberrations (HOA) after trabeculectomy using mitomycin-C (MMC). METHODS: We retrospectively reviewed data for 63 eyes from 63 glaucoma patients who had undergone MMC augmented trabeculectomy. We measured intraocular pressure (IOP), refractive errors, anterior chamber depth (ACD), and HOA before surgery and 1, 2, and 4 weeks postoperatively. The patients were divided into two groups on the basis of preoperative lens status: phakic and pseudophakic group...
December 22, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/29260553/ordered-mesoporous-tin-oxide-semiconductors-with-large-pores-and-crystallized-wall-for-high-performance-gas-sensing
#18
Xingyu Xiao, Liangliang Liu, Junhao Ma, Yuan Ren, Xiaowei Cheng, Yongheng Zhu, Dongyuan Zhao, Ahmed A Elzatahry, Abdulaziz Alghamdi, Yonghui Deng
Owing to their distinct chemical and physical properties, mesoporous metal oxide semiconductors have shown great application potential in catalysis, electrochemistry, energy conversion and energy storage. In this study, mesoporous crystalline SnO2 materials have been synthesized through an evaporation-induced co-assembly (EICA) method using poly(ethylene oxide)-b-polystyrene (PEO-b-PS) diblock copolymers as the template, tin chlorides as the tin sources and THF as the solvent. By controlling conditions of the co-assembly process and employing a carbon-supported thermal treatment strategy, highly ordered mesoporous SnO2 materials with hexagonal mesostructure (space group P63/mmc) and crystalline pore walls can be obtained...
December 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29258720/safety-of-intraperitoneal-mitomycin-c-versus-intraperitoneal-oxaliplatin-in-patients-with-peritoneal-carcinomatosis-of-colorectal-cancer-undergoing-cytoreductive-surgery-and-hipec
#19
W J van Eden, N F M Kok, K Woensdregt, A D R Huitema, H Boot, A G J Aalbers
BACKGROUND: Colorectal peritoneal carcinomatosis (PC) is commonly treated with cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). There is an ongoing international debate about which intraperitoneal chemotherapeutic agent is preferred, Mitomycin C (MMC) or oxaliplatin. We questioned whether the type of chemotherapeutic agent influenced postoperative complication rates or short-term survival. METHODS: In this retrospective cohort study patients with colorectal PC who underwent CRS-HIPEC between January 2010 and December 2016 were included...
November 15, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29249073/medical-and-socioeconomic-predictors-of-quality-of-life-in-myelomeningocele-patients-with-shunted-hydrocephalus
#20
Brij S Karmur, Abhaya V Kulkarni
INTRODUCTION: Children with myelomeningocele (MMC) often develop hydrocephalus, and the combination of these conditions can lead to psychosocial, cognitive, and physical health issues that decrease their health-related quality of life (HRQOL). The goal of the present study was to understand the QOL in patients with MMC and shunted hydrocephalus. METHODS: Data from the Toronto Hydrocephalus QOL Database was acquired between 2004 and 2009 using parent-completed questionnaires and, when appropriate, child-completed questionnaires: Hydrocephalus Outcome Questionnaire (HOQ) and the Health Utilities Index...
December 16, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
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