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Shahram Bamdad, Anis Shamsi Kooshki, Masoud Yasemi
Background: Pterygium is a common degenerative eye disease. Despite various surgical methods to treat pterygium, recurrence is the main complication. The main issue is finding a surgical method with the lowest recurrence. Objective: to compare the complications, recurrence rate and the cosmetic effects of two surgical techniques, namely conjunctival rotation autograft (CRA) and conjunctival autograft (CA), in treating pterygium. Methods: This randomized clinical trial was conducted at Khalili Hospital in Shiraz, Iran, from January to August 2015...
December 2017: Electronic Physician
Xin Zhang, Xiaoli Wang, Qinglin Wang, Xinjun Ma, Chunming Liu, Peifang Li, Cailong Liu, Yonghao Han, Yanzhang Ma, Chunxiao Gao
Hydride ions (H-) have an appropriate size for fast transport, which makes the conduction of H- attractive. In this work, the H- transport properties of BaH2 have been investigated under pressure using in situ impedance spectroscopy measurements up to 11.2 GPa and density functional theoretical calculations. The H- transport properties, including ionic migration resistance, relaxation frequency, and relative permittivity, change significantly with pressure around 2.3 GPa, which can be attributed to the structural phase transition of BaH2...
March 20, 2018: Physical Chemistry Chemical Physics: PCCP
Kathryn J Schunke, Lauren M Rosati, Marianna Zahurak, Joseph M Herman, Amol K Narang, Irina Usach, Alison P Klein, Charles J Yeo, Larry T Korman, Ralph H Hruban, John L Cameron, Daniel A Laheru, Ross A Abrams
Purpose: The purpose of this study was to report toxicity and long-term survival outcomes of 2 prospective trials evaluating mitomycin C (MMC) with 5-fluorouracil-based adjuvant chemoradiation in resected periampullary adenocarcinoma. Methods and materials: From 1996 to 2002, 119 patients received an adjuvant 4-drug chemotherapy regimen of 5-fluorouracil, leucovorin, MMC, and dipyridamole with chemoradiation on 2 consecutive trials (trials A and B). Trial A patients received upfront chemoradiation (50 Gy split-course, 2...
January 2018: Advances in Radiation Oncology
Weiwei Cao, Xiaoyan Yang, Fengqi Lu, Wenfeng Zhu, Laijun Liu, Xiaojun Kuang, Mathieu Allix
Isovalent substitution of Zr4+ for smaller Ti4+ was performed in the 8-layer twinned hexagonal perovskite (referred to as 8H) tantalate Ba8 Ti3 Ta4 O24 , which stabilizes a 10-layer twinned hexagonal perovskite (referred to as 10H). The formation of the 10H phase occurs at low substitution concentration ( x = 0.1) in Ba8 Zrx Ti3- x Ta4 O24 at 1300 °C and reverts back to the 8H phase upon heating at elevated temperatures. Such a 10H-to-8H phase transformation is suppressed at higher Zr-substitution contents ( x > 0...
March 19, 2018: Inorganic Chemistry
Hongbo Xie, Hucheng Pan, Yuping Ren, Liqing Wang, Yufeng He, Xixi Qi, Gaowu Qin
All of the AB_{2} Laves phases discovered so far satisfy the general crystalline structure characteristic of translational symmetry; however, we report here a new structured Laves phase directly precipitated in an aged Mg-In-Ca alloy by using aberration-corrected scanning transmission electron microscopy. The nanoprecipitate is determined to be a (Mg,In)_{2}Ca phase, which has a C14 Laves structure (hcp, space group: P6_{3}/mmc, a=6.25  Å, c=10.31  Å) but without any translational symmetry on the (0001)_{p} basal plane...
February 23, 2018: Physical Review Letters
Hongtao Yang, Xinhua Qu, Wenjiao Lin, Cong Wang, Donghui Zhu, Kerong Dai, Yufeng Zheng
Recent studies indicate that there is a great demand to optimize pure Zn with tunable degradation rates and more desirable biocompatibility as orthopedic implants. Metal matrix composite (MMC) can be a promising approach for this purpose. In this study, MMC with pure Zn as a matrix and hydroxyapatite (HA) as reinforcements were prepared by spark plasma sintering (SPS). Feasibility of novel Zn-HA composites to be used as orthopedic implant applications was systematically evaluated. After sintering, HA distributed in the Zn particle boundaries uniformly...
March 9, 2018: Acta Biomaterialia
A Walkden, J Huxtable, M Senior, H Lee, S Naylor, S Turner, K Ivanova, J Koppens, B Todd, A Macleod, F Sii, N Anand, P Shah, A King, D C Broadway, J F Kirwan, A McNaught, A Bhan-Bhargava
OBJECTIVES: To define the safety profile of trainee trabeculectomy surgery in the United Kingdom. Surgical exposure for trainees in England is limited due to service requirements, the European working time directive constraints and increasing sub-specialisation of glaucoma surgery. Limited knowledge exists on the outcomes of supervised glaucoma surgery. The aim is to determine the safety of supervised trabeculectomy surgery performed by trainee ophthalmologists. METHODS: Retrospective case note review of all patients that had trabeculectomy surgery with MMC by consultant and trainee surgeons across multiple UK centres...
March 12, 2018: Eye
Caifeng Xiong, Jie Yuan, Zhiying Wang, Siyao Wang, Chenchen Yuan, Lili Wang
In this work, 2-methacryloyloxyethyl phosphorylcholine (MPC) was used as a ligand to prepare a novel mixed-mode chromatography (MMC) stationary phase by the thiol-ene click reaction onto silica (MPC-silica). It was found that this MPC-silica showed the retention characteristics of hydrophilic interaction chromatography (HILIC) and weak cation exchange chromatography (WCX) under suitable mobile phase conditions. In detail, acidic and basic hydrophilic compounds and puerarin from pueraria were separated quickly with HILIC mode...
March 6, 2018: Journal of Chromatography. A
Gabriel Qualhato, Simone Maria Teixeira de Sabóia-Morais, Luciana Damacena Silva, Thiago Lopes Rocha
Although iron oxide nanoparticles (IONPs) have been widely used in nanomedicine and nanoremediation, their ecotoxicological effects on aquatic organisms remain unclear. In this study, the melanomacrophage center (MMC) response and hepatic histopathologic biomarkers were investigated in female guppies, Poecilia reticulata, exposed to citrate-functionalized IONPs (γ-Fe2 O3 ) at an environmentally relevant iron concentration (0.3 mg L-1 ) over 21 days. The animals were collected at the beginning of the experiment and after 3, 7, 14, and 21 days of exposure...
February 21, 2018: Aquatic Toxicology
M Graupp, B Rinner, M T Frisch, G Weiss, J Fuchs, M Sundl, A El-Heliebi, G Moser, L P Kamolz, M Karbiener, M Gugatschka
BACKGROUND: Vocal fold (VF) scarring remains a therapeutic dilemma and challenge in modern laryngology. To facilitate corresponding research, we aimed to establish an in vitro fibrogenesis model employing human VF fibroblasts (hVFF) and the principles of macromolecular crowding (MMC). METHODS: Fibrogenesis was promoted by addition of transforming growth factor-β1 to standard medium and medium containing inert macromolecules (MMC). Hepatocyte growth factor (HGF) and Botox type A were tested for their antifibrotic properties in various doses...
March 8, 2018: European Archives of Oto-rhino-laryngology
Anna Kovalchuk, Yaroslav Ilnytskyy, Rafal Woycicki, Rocio Rodriguez-Juarez, Gerlinde A S Metz, Olga Kovalchuk
Recent advances in cancer treatments have led to significant increases in cure rates. Most cancer patients are treated with various cytotoxic chemotherapy regimens. These treatment modalities are mutagenic and genotoxic and cause a wide array of late-occurring health problems, and even exert a deleterious influence on future offspring. The adverse effects from exposed parents on offspring are referred to as transgenerational effects, and currently little is known about chemotherapy-induced transgenerational effects...
February 9, 2018: Oncotarget
Daigo Ochiai, Hirotaka Masuda, Yushi Abe, Toshimitsu Otani, Marie Fukutake, Tadashi Matsumoto, Kei Miyakoshi, Mamoru Tanaka
Mesenchymal stem cells (MSCs) have generated great interest in the fields of regenerative medicine and immunotherapy because of their unique biological properties. Among MSCs, amniotic fluid stem cells (AFS) have a number of characteristics that make them attractive candidates for tissue engineering and cell replacement strategies, particularly for perinatal medicine. If various neonatal conditions, including birth asphyxia, preterm birth, and congenital abnormalities, which result in long-lasting severe impairments, could be predicted during pregnancy, it would allow collection of small samples of amniotic fluid cells by amniocentesis...
March 6, 2018: Keio Journal of Medicine
Ling Cao, Sheng Wang, Prakash Venglat, Lihua Zhao, Yan Cheng, Shengjian Ye, Yuan Qin, Raju Datla, Yongming Zhou, Hong Wang
In most plants, the female germline starts with the differentiation of one megaspore mother cell (MMC) in each ovule that produces four megaspores through meiosis, one of which survives to become the functional megaspore (FM). The FM further develops into an embryo sac. Little is known regarding the control of MMC formation to one per ovule and the selective survival of the FM. The ICK/KRPs (interactor/inhibitor of cyclin-dependent kinase (CDK)/Kip-related proteins) are plant CDK inhibitors and cell cycle regulators...
March 7, 2018: PLoS Genetics
Leticia Bignardi, Talita Prates, Andiara De Rossi, Paulo Nelson-Filho, Fabrício Kitasono de Carvalho, Talitha de Siqueira Mellara, Alexandra Mussolino de Queiroz
Myelomeningocele (MMC) is a congenital malformation that occurs in the embryonic period, characterized by failure in closure of the caudal portion of the neural tube during central nervous system formation. Alterations and complications can be associated with this condition, such as hydrocephalus, neurogenic bladder, orthopedic problems, and motor and cognitive impairment. This patients with MMC also have predisposition to develop latex allergy and high caries risk and activity due to deficient oral hygiene, fermentable carbon hydrate-rich diet and prolonged use of sugar-containing oral medications...
March 7, 2018: Special Care in Dentistry
Jorge Galindo-Villegas, Alicia García-Alcazar, José Meseguer, Victoriano Mulero
A key goal of a successful vaccine formulation is the strong induction of persistent protective immune responses without producing side-effects. Adjuvants have been proved to be successful in several species at inducing increased immune responses against poorly immunogenic antigens. Fish are not the exception and promising results of adjuvanted vaccine formulations in many species are needed. In this study, over a period of 300 days, we characterized the apparent damage and immune response in gilthead seabream immunized by intraperitoneal injection with the model antigen keyhole limpet hemocyanin (KLH) alone or formulated with Montanide ISA water-in-oil (761 or 763), or Imject™ aluminum hydroxide (aluminium), as adjuvants...
March 3, 2018: Fish & Shellfish Immunology
Z Y Wei, M M Feng, B Yang, Z Y Yan, B Q Wang, X Y Bu
Glioma is the most common primary tumor in the brain, accounting for about 40~50% of intracranial primary tumors. Most chemotherapeutic drugs have difficulty in penetrating the blood-brain barrier, and their clinical applications are greatly limited. We evaluated the effects of methylmercury-L-cysteine (MeHg-L-cys) and methylmercury chloride (MMC) on apoptosis of C6 glioma cells. L-type amino acid transporter (LAT1) was used to investigate the targeted transport function and cytotoxicity of MeHg- L-cys in glioma...
January 2018: Journal of Biological Regulators and Homeostatic Agents
Cherng-Ru Hsu, Yi-Hao Chen, Ming-Cheng Tai, Da-Wen Lu
BACKGROUND: This study aimed to study the long-term surgical outcomes of combined trabeculotomy-trabeculectomy (CTT) using the modified Safer Surgery System in treating childhood glaucoma at a tertiary medical center in Taiwan. METHODS: Retrospective, consecutive, noncomparative case series. We retrospectively reviewed medical records of 42 pediatric patients (age 0-18 years) who had CTT performed on their 65 eyes using the modified Safer Surgery System. The study period spanned 18 years (from January 1, 1997, to December 31, 2014)...
March 3, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
W-D U Böhm, R Koch, S Wenzel, M P Wirth, M Toma
Adjuvant therapy with different bacillus Calmette-Guérin (BCG) preparations is a well-established guideline-endorsed treatment for nonmuscle invasive bladder cancer (NMIBC). Our observational study demonstrates equality between BCG and mitomycin C (MMC) treatment based on the oncological outcome. However, there were significant toxicity differences with higher rates in the BCG treatment group. The potential adverse effects of BCG in terms of a BCGitis are controversially discussed regarding their occurrence...
March 2, 2018: Der Urologe. Ausg. A
Tiaoping Nie, Lijun Meng, Yanru Li, Yanhua Luan, Jun Yu
We investigated the electronic properties and phase transitions of Na3 Bi in four structural phases (space groups P63 /mmc, P [Formula: see text] c1, Fm [Formula: see text] m and Cmcm) under constant-volume uniaxial strain using the first-principles method. For P63 /mmc and P [Formula: see text] c1-Na3 Bi, an important phase transition from a topological Dirac semimetal (TDS) to a topological insulator appears under compression strain around 4.5%. The insulating gap increases with the increasing compressive strain and up to around 0...
February 28, 2018: Journal of Physics. Condensed Matter: An Institute of Physics Journal
Charlotte Rosenkrantz Bodin, Mikkel Mylius Rasmussen, Ann Tabor, Lena Westbom, Eleonor Tiblad, Charlotte Kvist Ekelund, Camilla Bernt Wulff, Ida Vogel, Olav Bjørn Petersen
Objectives: The aim of this study was to assess the incidence, the prenatal detection rate by ultrasound, and the pregnancy outcome of spina bifida (SB) in Denmark (DK) in 2008-2015 and to compare results to national data from Sweden. Methods: Data were retrieved from the Danish Fetal Medicine Database, which includes International Classification of Diseases- (ICD-) 10 codes for pre- or postnatally diagnoses and pregnancy outcome. Missing data were obtained from the National Patient Register...
2018: BioMed Research International
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