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https://www.readbyqxmd.com/read/29781298/treatment-of-dental-biofilm-with-a-tincture-of-bauhinia-forficata-leaves-an-ex-vivo-study
#1
Julio Cesar C Ferreira-Filho, Andressa Temperini de Oliveira Marre, Juliana Soares de Sá Almeida, Leandro Araújo Lobo, Adriana Farah, Ana Maria Gondim Valença, Andréa Fonseca-Gonçalves
The inhibitory activity of a Bauhinia forficata tincture (TBF) was investigated against oral microorganism's strains and against a mature oral biofilm. The viability of planktonic cells was analyzed by Minimal Inhibitory and Microbicidal concentrations of TBF. Salivary samples from health volunteers were collected and mixed to form a saliva pool. An aliquot from this pool were seeded on membranes, which were incubated to form biofilm (48 h). The biofilm was treated according to the groups: G1-Chlorhexidine 0...
May 21, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29780903/refractory-interface-haze-developing-after-epithelial-ingrowth-following-laser-in-situ-keratomileusis-and-small-aperture-corneal-inlay-implantation
#2
Rafic Antonios, Nada S Jabbur, Mohammed A Ahmed, Shady T Awwad
Purpose: To report the occurrence and the management of refractory interface haze that developed after epithelial ingrowth following small aperture inlay implantation. Observations: A 52 year-old man with sub-clinical anterior basement membrane dystrophy (ABMD) underwent combined hyperopic laser in situ keratomileusis and KAMRA corneal inlay implantation to correct presbyopia. Post-operatively, epithelial ingrowth developed requiring debridement and KAMRA removal...
June 2018: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29775799/exploding-asthma-and-adhd-caseloads-the-role-of-medicaid-managed-care
#3
Anna Chorniy, Janet Currie, Lyudmyla Sonchak
In the U.S., nearly 11% of school-age children have been diagnosed with ADHD, and approximately 10% of children suffer from asthma. In the last decade, the number of children diagnosed with these conditions has inexplicably been on the rise. This increase has been concentrated in the Medicaid caseload nationwide. One of the most striking changes in Medicaid has been the transition from fee-for-service (FFS) reimbursement to Medicaid managed care (MMC), which had taken place in 80% of states by 2016. Using Medicaid claims from South Carolina, we show that this change contributed to the increase in asthma and ADHD caseloads...
May 7, 2018: Journal of Health Economics
https://www.readbyqxmd.com/read/29775624/characterization-and-comparative-analysis-of-a-new-mouse-microglial-cell-model-for-studying-neuroinflammatory-mechanisms-during-neurotoxic-insults
#4
Souvarish Sarkar, Emir Malovic, Deeksha Sarda, Vivek Lawana, Dharmin Rokad, Huajun Jin, Vellareddy Anantharam, Arthi Kanthasamy, Anumantha G Kanthasamy
Microglia are the first responders of the central nervous system, acting as the key modulators of neuroinflammation observed during neurotoxic insults as well as in the pathophysiology of several neurodegenerative disorders including Alzheimer's (AD), Parkinson's (PD), and Huntington's diseases (HD). The number of publications on microglia has increased steadily throughout the past decade because of immense interests in the neuroinflammation that precedes the neurodegenerative process. To study microglial biology and its role in modulating neuroinflammation, immortalized microglial cell lines derived from mice, rats, and humans have been developed...
May 15, 2018: Neurotoxicology
https://www.readbyqxmd.com/read/29774802/the-notion-of-manhood-embedment-in-the-practice-of-traditional-male-circumcision-in-ngove-village-limpopo-south-africa
#5
Tryphosa Siweya, Tholene Sodi, Mbuyiselo Douglas
Traditional male circumcision (TMC) is a cultural ritual that involves the removal of the penile foreskin of a male person undertaken as part of a rite of passage from childhood into adulthood. The aim of the study was to determine the notions of manhood in TMC by African adolescent boys in Ngove Village, Limpopo Province. This was a qualitative study that sampled a total of 20 adolescent boys through purposive sampling. Data were collected using semistructured interviews and analyzed through interpretive phenomenological analysis (IPA)...
May 1, 2018: American Journal of Men's Health
https://www.readbyqxmd.com/read/29774126/autophagy-deficient-breast-cancer-shows-early-tumor-recurrence-and-escape-from-dormancy
#6
Hussein F Aqbi, Liliya Tyutyunyk-Massey, Rebecca C Keim, Savannah E Butler, Theresa Thekkudan, Supriya Joshi, Timothy M Smith, Dipankar Bandyopadhyay, Michael O Idowu, Harry D Bear, Kyle K Payne, David A Gewirtz, Masoud H Manjili
Breast cancer patients who initially respond to cancer therapies often succumb to distant recurrence of the disease. It is not clear why people with the same type of breast cancer respond to treatments differently; some escape from dormancy and relapse earlier than others. In addition, some tumor clones respond to immunotherapy while others do not. We investigated how autophagy plays a role in accelerating or delaying recurrence of neu-overexpressing mouse mammary carcinoma (MMC) following adriamycin (ADR) treatment, and in affecting response to immunotherapy...
April 24, 2018: Oncotarget
https://www.readbyqxmd.com/read/29773200/lithium-chloride-attenuates-mitomycin-c-induced-necrotic-cell-death-in-mda-mb-231-breast-cancer-cells-via-hmgb1-and-bax-signaling
#7
Mahdieh Razmi, Azra Rabbani-Chadegani, Fatemeh Hashemi-Niasari, Parinaz Ghadam
The clinical use of potent anticancer drug mitomycin C (MMC) has limited due to side effects and resistance of cancer cells. The aim of this study was to investigate whether lithium chloride (LiCl), as a mood stabilizer, can affect the sensitivity of MDA-MB-231 breast cancer cells to mitomycin C. The cells were exposed to various concentrations of mitomycin C alone and combined with LiCl and the viability determined by trypan blue and MTT assays. Proteins were analyzed by western blot and mRNA expression of HMGB1 MMP9 and Bcl-2 were analyzed by RT-PCR...
July 2018: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/29770571/using-poly-l-lactic-acid-and-poly-%C3%A9-caprolactone-blends-to-fabricate-self-expanding-watertight-and-biodegradable-surgical-patches-for-potential-fetoscopic-myelomeningocele-repair
#8
Rigwed Tatu, Marc Oria, Sarah Pulliam, Lorenzo Signey, Marepalli B Rao, Jose L Peiro, Chia-Ying Lin
Our study focuses on the development and characterization of a self-expanding, watertight and biodegradable patch for fetoscopic myelomeningocele (MMC) prenatal repair. We fabricated poly(l-lactic acid) (PLA) and poly(ɛ-caprolactone) (PCL) blend films by solution casting. Formulation c with average glass transition temperature of 37.6 ± 1.2°C was chosen for temporospatial recovery. Favorable results from surface studies reflected homogeneous dispersion of polymers in the blend. The cytotoxicity was studied in human foreskin fibroblasts...
May 16, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29767247/comparison-of-the-synergistic-anticancer-activity-of-alpcs4-photodynamic-therapy-in-combination-with-different-low%C3%A2-dose-chemotherapeutic-agents-on-gastric-cancer-cells
#9
Jing Xin, Senhao Wang, Luwei Zhang, Bo Xin, Yulu He, Jing Wang, Sijia Wang, Lijian Shen, Zhenxi Zhang, Cuiping Yao
Limited cellular delivery and internalization efficiency of Al(III) phthalocyanine chloride tetrasulfonic acid (AlPcS4) induce poor penetration ability in cells and a slight photodynamic therapy (PDT) effect on gastric cancer. The combination treatment of AlPcS4/PDT with low‑dose chemotherapeutic agents may provide a promising treatment strategy to increase the weak delivery efficiency of AlPcS4, reducing the dose of chemical agents without reducing efficacy, and improving apoptosis‑inducing abilities, thereby increasing the antitumor effects and decreasing the noxious side effects on gastric cancer...
May 16, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29763373/oral-glucose-challenge-impairs-skeletal-muscle-microvascular-blood-flow-in-healthy-people
#10
Ryan D Russell, Donghua Hu, Timothy Greenaway, James E Sharman, Stephen Rattigan, Stephen M Richards, Michelle A Keske
Skeletal muscle microvascular (capillary) blood flow increases in the post-prandial state or during insulin infusion due to dilation of pre-capillary arterioles to augment glucose disposal. This effect occurs independent of changes in large artery function. However, acute hyperglycemia impairs vascular function, causes insulin to vasoconstrict pre-capillary arterioles, and causes muscle insulin resistance in vivo. We hypothesize that acute hyperglycemia impairs post-prandial muscle microvascular perfusion, without disrupting normal large artery hemodynamics, in healthy humans...
May 15, 2018: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29761828/differential-micronucleus-frequency-in-isogenic-human-cells-deficient-in-dna-repair-pathways-is-a-valuable-indicator-for-evaluating-genotoxic-agents-and-their-genotoxic-mechanisms
#11
Liton Kumar Saha, Sujin Kim, Habyeong Kang, Salma Akter, Kyungho Choi, Tetsushi Sakuma, Takashi Yamamoto, Hiroyuki Sasanuma, Kouji Hirota, Jun Nakamura, Masamitsu Honma, Shunichi Takeda, S Dertinger
The micronucleus (MN) test has become an attractive tool both for evaluating the genotoxicity of test chemicals because of its ability to detect clastogenic and aneugenic events and for its convenience. As the MN assay has been mostly performed using only DNA repair-proficient mammalian cells, we believed that the comparison of the MN frequency between DNA repair-proficient and -deficient human cells may be an excellent indicator for detecting the genotoxic potential of test chemicals and for understanding their mode of action...
May 15, 2018: Environmental and Molecular Mutagenesis
https://www.readbyqxmd.com/read/29759254/protein-separation-using-a-novel-silica-based-rplc-iec-mixed-mode-stationary-phase-modified-with-n-methylimidazolium-ionic-liquid
#12
Quan Bai, Yanna Liu, Yixin Wang, Kailou Zhao, Fan Yang, Jiawei Liu, Jiwei Shen, Qingyang Zhao
Ionic liquids (ILs) immobilized on silica as a novel high-performance liquid chromatography (HPLC) stationary phase have attracted considerable attentions. However, it has not been applied to protein separation. In this paper, N-methylimidazolium IL-modified silica-based stationary phase (SilprMim) was prepared and investigated as a novel multi-interaction stationary phase with positive charges for protein separation. The results indicate that all of the basic proteins tested cannot be adsorbed on this novel stationary phase, whereas all of the acidic proteins tested can be retained, and the baseline separation of eight kinds of acidic protein standards can be achieved when being performed under reversed phase/ion-exchange chromatography (RPLC/IEC) mode...
August 1, 2018: Talanta
https://www.readbyqxmd.com/read/29757766/comorbidities-associated-with-early-mortality-in-adults-with-spina-bifida
#13
Brad E Dicianno, Adam Sherman, Christian Roehmer, Christina K Zigler
OBJECTIVE: The purpose of this quality improvement project was to identify secondary conditions and medical comorbidities in adult patients with spina bifida and to determine which factors were associated with an earlier age of death. DESIGN: Retrospective chart review of 487 patients who attended the University of Pittsburgh Medical Center (UPMC) Adult Spina Bifida Clinic between August 1, 2005 and June 6, 2017. RESULTS: Out of 487 patients who had received care at the UPMC Adult Spina Bifida Clinic, 48 were deceased...
May 11, 2018: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/29756769/prediction-of-new-phase-and-electrochemical-properties-of-li-2-s-2-for-the-application-of-li-s-batteries
#14
Y Pan, W M Guan
The intermediate product Li2 S2 plays a pivotal role in the charge/discharge process of lithium-sulfur batteries. However, the structural configuration and relevant properties of Li2 S2 are unclear. In this work, by using ab initio calculations, we present results of novel phases, average open circuit voltages ( Voc s), and electronic properties of the stable Li2 S2 . Two new Li2 S2 phases are predicted: orthorhombic ( Cmca) and orthorhombic ( Immm) structures. The calculated Voc s of hexagonal ( P63 / mmc), orthorhombic ( Cmca), and orthorhombic ( Immm) are 3...
May 14, 2018: Inorganic Chemistry
https://www.readbyqxmd.com/read/29750436/fetal-blood-gas-values-during-fetoscopic-myelomeningocele-repair-performed-under-carbon-dioxide-insufflation
#15
Ahmet A Baschat, Edward S Ahn, Jamie Murphy, Jena L Miller
BACKGROUND: Fetoscopic myelomeningocele (MMC) repair is performed with intrauterine carbon dioxide (CO2 ) insufflation. While lamb experiments have shown significant fetal acidemia following CO2 insufflation corresponding information for human pregnancies is not available. CASES: We performed umbilical venous cord blood sampling in three patients during fetoscopic MMC repair at 25+1, 25+3 and 24+1 weeks gestation. Fetal venous pH at the beginning of CO2 insufflation were 7...
May 10, 2018: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29745935/-sequential-treatment-with-mitomycin-c-and-bcg-in-non-muscle-invasive-bladder-cancer
#16
Venancio Chantada-Abal, Cristina Chantada-Tirado, Leticia Lamas-Díaz, Francisco Caramés-Masana, Anselmo Damián Villegas-Piguave, Nuria Villar-Vázquez
Bacilus Calmette-Guerin (BCG) administered intravesical is an effective therapy in non muscle invasive bladder cancer (NMIBC), but it presents limitations regarding recurrence and toxicity. For years, many case series have been published where sequential therapy with BCG and Mitomycin C (MMC) was tried. In this article, we perform a review of the data supplied by these articles with the aim to determine the safety and efficacy of combination, and what is the group of patients it should be indicated. Many studies show that combination therapy did not cause more toxicity and improved the interval free of disease with decrease of tumor progression compared to BCG or MMC monotherapy...
May 2018: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/29745933/neoadjuvant-chemohyperthermia-our-experience-after-10-years
#17
Alejandro Sousa Escandón, Juan León Mata, Daniel Sousa González, María Alvarez Casal, Silvia Rodríguez, Sara Piñeiro Vazquez
Neoadjuvant chemohyperthermia (QHT) with MMC has demonstrated its efficacy in NMIBC both in the level of complete response at the time of TURBT and reduction of recurrences after several years of follow up. We present our experience with this treatment. METHODS: We performed a case control study in a group of 104 patients with middle-high risk NMIBC. 43 of them received neoadjuvant recirculated intravesical QHT and 61 passively administered standard adjuvant MMC. Patient follow up was 43 months (3 - 108) evaluating their clinical efficacy and adverse effects in both groups...
May 2018: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/29745932/analysis-of-tolerance-and-security-of-chemo-hyperthermia-with-mitomycin-c-for-the-treatment-of-non-muscle-invasive-bladder-cancer
#18
Juan León-Mata, José Luis Domínguez, Joan Palou Redorta, Daniel Sousa González, María Alvarez Casal, Alejandro Sousa Escandón, Eva Piñeiro Vázquez
OBJECTIVES: The treatment of non muscle invasive bladder cancer (NMIBC) continues to be a challenge. Hyperthermia (HT) combined with intravesical chemotherapy is used to enhance the effects of chemotherapy. METHODS: A review of the publications was carried out to synthesize the adverse effects (AE) reported by the use of chemohyperthermia (QHT) with Mitomycin-C (MMC). The most relevant data are exposed for each of the devices currently used in the QHT. RESULTS: SYNERGO®: The dropout rate varied between 3-40%, and the AE rate is up to 88%...
May 2018: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/29745930/-emda-with-mmc-critical-review
#19
Eduardo Solsona
Two Phase II studies, three Phase III and one observational study seem to justify that EMDA-MMC is a real alternative in the treatment of patients with NMIBC, especially the high risk group. The phase III studies compare EMDA-MMC with passive diffusion MMC and BCG in patients with bladder TIS. They showed EMDA MMC superiority compared to passive diffusion MMC and similar to BCG in achieving complete response at 3 and 6 months. In another randomized study on pT1 NMIBC patients, comparing a sequential scheme of BCG plus EMDA-MMC and BCG, the sequential regimen was significantly superior than BCG reducing recurrence and progression and improved overall and specific survivals...
May 2018: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/29745929/-chemohyperthermia-using-mmc-in-non-muscle-invasive-bladder-cancer-current-status-and-future-perspectives
#20
Jacqueline J M J H Coenen, F Johannes P van Valenberg, Tom J H Arends, J Alfred Witjes
In an effort to decrease recurrence and progression rates in non-muscle-invasive bladder cancer (NMIBC), transurethral resection of a bladder tumor is followed by intravesical instillations using Mitomycin-C (MMC) and Bacillus Calmette-Guérin (BCG). In spite of these adjuvant treatment modalities, recurrence and progression rates remain high. Because of these limitations of current standard therapy and the shortage of BCG, there is a search for alternative forms of treatment in NMIBC. Intravesical MMC combined with hyperthermia, especially RF-induced QHT being most extensively investigated in the past 20 years, is one of these alternatives for intermediate- and high-risk NMIBC...
May 2018: Archivos Españoles de Urología
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