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Michael Metcalfe, Gavin Wagenheim, Lianchun Xiao, John Papadopoulos, Neema Navai, John W Davis, Jose A Karam, Ashish M Kamat, Christopher G Wood, Colin P Dinney, Surena F Matin
PURPOSE: Endoscopic management of upper tract urothelial carcinoma (UTUC) is associated with higher recurrences, which could be reduced by application of topical therapy. Adjuvant induction Bacillus Calmette-Guerin has shown inferior outcomes for UTUC compared to bladder cancer, and maintenance regimens for UTUC are unexplored. We report on the efficacy, safety, and tolerability of Mitomycin C (MMC) induction and maintenance adjuvant topical therapy for UTUC. MATERIALS AND METHODS: Patients with UTUC who received adjuvant topical therapy after complete endoscopic control of Ta/T1 tumors were retrospectively reviewed...
July 21, 2017: Journal of Endourology
Karyn A Goodman, Diana Julie, Andrea Cercek, Lajhem Cambridge, Kaitlin M Woo, Zhigang Zhang, Abraham J Wu, Diane L Reidy, Neil H Segal, Zsofia K Stadler, Leonard B Saltz
PURPOSE: To assess the impact on acute toxicity of replacing 5-fluorouracil (5-FU) with capecitabine in definitive chemoradiation for patients with anal squamous cell carcinoma (ASCC). METHODS AND MATERIALS: We retrospectively reviewed the records of 107 consecutive patients with nonmetastatic ASCC treated with definitive chemoradiation from January 2009 to May 2014. In 2011, based on the noninferiority of capecitabine versus 5-FU, our institutional practice shifted to use capecitabine instead of 5-FU for ASCC...
August 1, 2017: International Journal of Radiation Oncology, Biology, Physics
Drahomira Knitlova, Pavlina Hulinska, Michal Jeseta, Katerina Hanzalova, Bartosz Kempisty, Marie Machatkova
The present study was designed to define the impact of l-carnitine, supplemented during maturation, on bovine oocytes with different meiotic competence in terms of their IVF outcomes. Meiotically more competent (MMC) and less competent (MLC) oocytes were obtained separately from differently sized follicles at selected phases of folliculogenesis. The oocytes were matured with or without l-carnitine, fertilized and cultured to the blastocyst stage. The oocytes were examined for nuclear maturation, mitochondrial cluster formation, lipid consumption, fertilization and embryo development...
July 5, 2017: Theriogenology
Jayant Venkatramani Iyer, Yang Zhao, Fiona Pin Miao Lim, Louis Tong, Tina Tzee Ling Wong
BACKGROUND: Chronic use of intraocular pressure-lowering medications is associated with ocular surface disease (OSD). In this study, we assess the incidence of topical lubricant use as a surrogate marker for underlying OSD, in medically and surgically treated glaucoma patients. METHODS: Retrospective chart review was performed for newly diagnosed glaucoma patients who were started on topical medications in 2007 and followed up over a 5-year period. Primary outcome measure was the incidence of topical lubricant use in these patients and a subset of these patients who required glaucoma or cataract surgery during follow-up...
2017: Clinical Ophthalmology
Judith Bosschieter, Jakko A Nieuwenhuijzen, Tessa van Ginkel, André N Vis, Birgit Witte, Don Newling, Goedele M A Beckers, R Jeroen A van Moorselaar
BACKGROUND: The efficacy of an immediate single chemotherapy instillation after transurethral resection of a bladder tumour (TURBT) in patients with non-muscle-invasive bladder cancer (NMIBC) remains a topic of debate. Evidence is even more scarce when an immediate instillation is followed by adjuvant instillations. OBJECTIVE: To compare the effect of a mitomycin C (MMC) instillation within 24h to an instillation 2 wk after TURBT in patients with NMIBC with or without adjuvant instillations...
July 10, 2017: European Urology
Ping Ma, Nazia Hussain, Marisa Abbe
BACKGROUND: Traffic-related injuries are the leading fatal injury among children in the US, but no published study compares the different types of traffic-related pediatric injuries to date. Thus, this study aims to examine the10 year trend of traffic-related injury among children at a pediatric hospital and to assess if there were differences in injury mechanism. METHODS: All data were drawn from a Level-1 Pediatric Trauma center in North Texas 2005-2014. Demographic characteristics, length of hospitalization (LOS) and patient type were included...
July 8, 2017: Journal of Trauma and Acute Care Surgery
Rachel Shujuan Chong, Ying Shi Lee, Stephanie Wai Ling Chu, Li Zhen Toh, Tina Tzee Ling Wong
Purpose: To evaluate the effect of treatment with monocyte chemoattractant protein-1 receptor inhibitor (MCP-Ri) to maintain bleb survival and prevent fibrosis in an experimental model of glaucoma filtration surgery (GFS). Methods: GFS was performed on one eye of C57/Bl6 mice (n = 36) that was treated with MCP-Ri, mitomycin-C (MMC), or vehicle at the time of surgery. Real-time polymerase chain reaction was used to evaluate conjunctival expression of monocyte chemoattractant protein-1 (MCP-1), TGFB1, TGFB2, collagen 1a1 (Col1a1), sparc (Sparc), and fibronectin at 2 and 7 days following surgery...
July 1, 2017: Investigative Ophthalmology & Visual Science
Kateki Vinod, Steven J Gedde, William J Feuer, Joseph F Panarelli, Ta C Chang, Philip P Chen, Richard K Parrish
PURPOSE: The purpose of this study is to assess surgical practice patterns among the American Glaucoma Society (AGS) membership. METHODS: An anonymous online survey evaluating the use of glaucoma surgeries in various clinical settings was redistributed to AGS members. Survey responses were compared with prior results from 1996, 2002, and 2008 to determine shifts in surgical practice patterns. Questions were added to assess the preferred approach to primary incisional glaucoma surgery and phacoemulsification combined with glaucoma surgery...
July 7, 2017: Journal of Glaucoma
Kati Erdmann, Jessica Ringel, Silke Hampel, Manfred P Wirth, Susanne Fuessel
We have previously shown that carbon nanofibers (CNFs) and carbon nanotubes (CNTs) can sensitize prostate cancer (PCa) cells to platinum-based chemotherapeutics. In order to further verify this concept and to avoid a bias, the present study investigates the chemosensitizing potential of CNFs and CNTs to the conventional chemotherapeutics docetaxel (DTX) and mitomycin C (MMC), which have different molecular structures and mechanisms of action than platinum-based chemotherapeutics. DU-145 PCa cells were treated with DTX and MMC alone or in combination with the carbon nanomaterials...
2017: Beilstein Journal of Nanotechnology
Ali Serdar Gözen, Paolo Umari, Walter Scheitlin, Fuat Ernis Su, Yigit Akin, Jens Rassweiler
Background&Aim: High grade non-muscle invasive bladder cancer (NMIBC) is common in urological practice. Most of these cancers are or become refractory to intravesical immunotherapy and chemotherapy. Here we evaluated the efficacy of combined local bladder hyperthermia and intravesical mitomycin-C (MMC) instillation in patients with high-risk recurrent NMIBC. MATERIALS AND METHODS: Between February 2014 and December 2015, 18 patients with high risk NMIBC were enrolled. Patients were treated in an outpatient basis with 6 weekly induction sessions followed by monthly maintenance sessions with intravesical MMC in local hyperthermia with bladder wall thermo-chemotherapy (BWT) system (PelvixTT system, Elmedical Ltd...
June 30, 2017: Archivio Italiano di Urologia, Andrologia
Susy R Lemes, Dwight A Chaves, Nelson J DA Silva, Cristiene C Carneiro, Lee Chen-Chen, Luciane M DE Almeida, Pablo J Gonçalves, Paulo R DE Melo-Reis
The aim of this study was to evaluate the possible protective of C. guianensis oil against MMC and CP, which are direct- and indirect-acting chemical mutagens, using the micronucleus test. Three experiments were performed. First the C. guianensis oil was co-administered to mice at doses of 250, 500 and 1000 mg/kg bw with 4 mg/kg bw MMC or 50 mg/kg bw CP. Second, the mutagenic drug (CP) was administered ip 50 mg/kg bw and after 6 and 12 hours 250 and 500 mg/kg bw of C. guianensis oil were administered. In the last, C...
June 29, 2017: Anais da Academia Brasileira de Ciências
Kejun Bu, Jianqiao He, Xiaofang Lai, Changsheng Song, Dong Wang, JiJian Xu, Sishun Wang, Fuqiang Huang
The mixed-metal sulfide compound with the formula Ba2Fe0.6V1.4S6 was successfully synthesized via solid-state reaction. Ba2Fe0.6V1.4S6 has a quasi-one-dimensional structure and crystallizes in the hexagonal space group P63/mmc. The structure is composed of face-sharing anion octahedron [MS6](8-) (M = V or Fe) units to construct infinite chains along the c axis, in which the Fe atoms randomly occupy the V sites. The Ba(2+) ions reside between adjacent chains. Magnetic susceptibility measurements reveal a transition between paramagnetism and ferromagnetism around 25 K...
July 17, 2017: Inorganic Chemistry
Esther Papaseit, Eulàlia Olesti, Rafael de la Torre, Marta Torrens, Magí Farré
Background Mephedrone (4-methylmethcathinone, 4-MMC), a ring-substituted synthetic cathinone derivative has become established as a permanent illicit drug in the dynamic new psychoactive substances (NPS) scene. Objective This review summarizes current knowledge on mephedrone concentrations in biological samples from cases of acute intoxications (fatal and non-fatal), pharmacokinetics studies, wastewater and anonymous pooled urine analysis in order to provide an overview of the reliable scientific knowledge on toxicokinetics of mephedrone in humans...
July 4, 2017: Current Pharmaceutical Design
Ratsada Praphasawat, Narongsak Munkong
Cratoxylum formosum Dyer is the Thai vegetable which commonly consumed a fresh leaves. In this study, we extracted Cratoxylum formosum with water and tested the extract for genotoxicity and anti-genotoxicity effects. We carried out the experiment using micronucleus test and comet assay in TK6 cells. In micronucleus experiment, we used cytokinesis-block proliferation technique to stop cell division which produced a cell at binucleated (BNC) stage. The comet assay was carried out after pre-treatment the cell with C...
June 25, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
Eleni Nikita, Alexandre Moulin, Ioannis Vergados, Dimitrios Brouzas, Panagiotis G Theodossiadis
INTRODUCTION: Tumor necrosis factor-α (TNF-α) is a multifunctional, proinflammatory cytokine that mediates pleiotropic biological functions, especially inflammation and immunoregulation. We hypothesized that blocking TNF-α with a monoclonal antibody would decrease inflammation and subconjunctival scarring in an animal model of experimental filtration surgery. METHODS: In a randomized, prospective, masked-observer study, 30 New Zealand albino rabbits underwent glaucoma filtration surgery...
July 1, 2017: Ophthalmology and Therapy
Tengfei Jiang, Baptiste Polteau, Yoann Farré, Laurent Cario, Camille Latouche, Yann Pellegrin, Mohammed Boujtita, Fabrice Odobel, Franck Tessier, François Cheviré, Stéphane Jobic
Nickel carbodiimide (NiCN2) was synthesized using a two-step precipitation-decomposition route leading to a brown powder with gypsum-flower-like morphology and a large specific surface area (75 m(2)/g). This layered material crystallizes in the 2H structure type of delafossite (space group P63/mmc), which is built upon infinite (2)/∞[NiN2] layers connected by linear carbodiimide ([N═C═N](2-)) bridges. An X-ray diffraction Rietveld refinement and thermal analyses pointed out some nickel deficiencies in the material, and band structure calculations carried out on the defect compound predicted p-type conductivity in relation to a slight amount of N(2-)...
July 17, 2017: Inorganic Chemistry
K W Romański
The migrating motility complex (MMC), a cyclical phenomenon, represents rudimentary motility pattern in the gastrointestinal tract. The MMC is observed mostly in the stomach and gut of man and numerous animal species. It contains three or four phases, while its phase III is the most characteristic. The mechanisms controlling the pattern are unclear in part, although the neural control of the MMC seems crucial. The main goal of this article was to discuss the importance of intrinsic innervation of the gastrointestinal tract in MMC initiation, migration, and cessation to emphasize that various MMC-controlling mechanisms act through the enteric nervous system...
June 1, 2017: Physiology International
Saimeng Jin, Fergal Byrne, Con Robert McElroy, James Sherwood, James H Clark, Andrew J Hunt
Many traditional solvents have drawbacks including sustainability and toxicity issues. Legislation, such as REACH, is driving the move towards less hazardous chemicals and production processes. Therefore, safer bio-based solvents need to be developed. Herein, a 10 step method has been proposed for the development of new bio-based solvents, which utilises a combination of in silico modelling of Hansen solubility parameters (HSPs), experimental Kamlet-Abboud-Taft parameters, a selection of green synthetic routes followed by application testing and toxicity measurements...
June 29, 2017: Faraday Discussions
J D Borucinska, D Morka, Z Grabowski, H Smith
Selected biomarkers of health were examined in 50 post-spawning cod Gadus morhua collected in November 2015 from the southern Baltic. The biomarkers included condition factor (CF), macroscopic lesions, histopathology of spleen, liver and gonads, and morphometry of follicular atresia and hepatic and splenic melanomacrophage cells (MMC). All fish appeared in good body condition. One fish had a dermal ulcer, and in seven, macroscopic nematodes were noted within body cavity. Microscopic lesions in the liver included biliary myxozoanosis, microsporidial and necrocentric granulomas, parasitic hepatitis, multifocal necrosis, foci of cellular alterations, spongiosis, peliosis and cytoplasmic fibrillar inclusions...
June 29, 2017: Journal of Fish Diseases
Marc Grifell, Mireia Ventura, Xoán Carbón, Pol Quintana, Liliana Galindo, Álvaro Palma, Ivan Fornis, Cristina Gil, Magi Farre, Marta Torrens
OBJECTIVE: This paper aims to present results of the analysis of clephedrone (4-CMC), 4-chloroethcathinone (4-CEC), and brephedrone (4-BMC) on recreational drug markets and a systematic review of all the available information concerning these substances. MATERIAL AND METHODS: Samples collected by the drug checking service of the Spanish harm reduction NGO-Energy Control were analyzed and systematic research was conducted. Between June 2014 and October 2016, 1,471 samples with at least one NPS were analyzed, 397 of which contained cathinones...
May 2017: Human Psychopharmacology
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