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https://www.readbyqxmd.com/read/28806949/case-report-of-ocular-kaposi-s-sarcoma
#1
Jing Yang, Xiao-Fang Yin, Yong-Ping Li, Shi-You Zhou
BACKGROUND: Kaposi's sarcoma (KS) is generally considered a neoplastic disorder of vascular origin and occurs in patients with acquired immunodeficiency syndrome (AIDS) or who have received immunosuppressive treatments after an organ transplant (Soulier et al., Blood 86(4):1276-80, 1995; Viejo-Borbolla and Schulz, AIDS Rev 5(4):222-9, 2003; Schulz, J Antimicrob Chemother 45(Suppl T3):15-27, 2000; Aversa et al. Crit Rev Oncol Hematol 53(3):253-65, 2005; Mbulaiteye and Engels, Int J Cancer 119(11):2685-91, 2006; Tessari et al...
August 14, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28806455/association-of-state-access-standards-with-accessibility-to-specialists-for-medicaid-managed-care-enrollees
#2
Chima D Ndumele, Michael S Cohen, Paul D Cleary
Importance: Medicaid recipients have consistently reported less timely access to specialists than patients with other types of coverage. By 2018, state Medicaid agencies will be required by the Center for Medicare and Medicaid Services (CMS) to enact time and distance standards for managed care organizations to ensure an adequate supply of specialist physicians for enrollees; however, there have been no published studies of whether these policies have significant effects on access to specialty care...
August 14, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28798741/deinococcus-radiodurans-toxin-antitoxin-mazef-dr-mediates-cell-death-in-response-to-dna-damage-stress
#3
Tao Li, Yulan Weng, Xiaoqiong Ma, Bing Tian, Shang Dai, Ye Jin, Mengjia Liu, Jiulong Li, Jiangliu Yu, Yuejin Hua
Here we identified a functional MazEF-dr system in the exceptionally stress-resistant bacterium D. radiodurans. We showed that overexpression of the toxin MazF-dr inhibited the growth of Escherichia coli. The toxic effect of MazF-dr was due to its sequence-specific endoribonuclease activity on RNAs containing a consensus 5'ACA3', and it could be neutralized by MazE-dr. The MazF-dr showed a special cleavage preference for the nucleotide present before the ACA sequence with the order by U>A>G>C. MazEF-dr mediated the death of D...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28791628/mitomycin-c-hypoxic-pelvic-perfusion-for-unresectable-recurrent-rectal-cancer-pharmacokinetic-comparison-of-surgical-and-percutaneous-techniques
#4
Stefano Guadagni, Giammaria Fiorentini, Marco Clementi, Paola Palumbo, Andrea Mambrini, Francesco Masedu
Patients with unresectable recurrent rectal cancer that progresses after standard and multi-modular treatments are candidates for hypoxic pelvic perfusion. Hypoxic pelvic perfusion can be performed using a surgical or percutaneous approach. The aim of this study was to examine whether the surgical and percutaneous approaches are comparable with respect to tumor drug exposure in the pelvis. A pharmacokinetic study was performed in 18 patients. Both the surgical and percutaneous procedures were performed using mitomycin C (MMC) at a dose of 25 mg/m(2)...
August 8, 2017: Updates in Surgery
https://www.readbyqxmd.com/read/28791228/management-of-bladder-neck-stenosis-and-urethral-stricture-and-stenosis-following-treatment-for-prostate-cancer
#5
REVIEW
Helen L Nicholson, Yasser Al-Hakeem, Javier J Maldonado, Vincent Tse
The aim of this review is to examine all urethral strictures and stenoses subsequent to treatment for prostate cancer, including radical prostatectomy (RP), radiotherapy, high intensity focused ultrasound (HIFU) and cryotherapy. The overall majority respond to endoscopic treatment, including dilatation, direct visual internal urethrotomy (DVIU) or bladder neck incision (BNI). There are adjunct treatments to endoscopic management, including injections of corticosteroids and mitomycin C (MMC) and urethral stents, which remain controversial and are not currently mainstay of treatment...
July 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28782297/a-reciprocal-inhibition-between-arid1-and-met1-in-male-and-female-gametes-in-arabidopsis
#6
Lei Li, Wenye Wu, Youshang Zhao, Binglian Zheng
Both female and male gametophytes harbor companion cells and gametes. MET1, a DNA methyltransferase, is down-regulated in companion cells. However, how MET1 is differentially regulated in gametophytes remains unexplored. ARID1, a transcription factor that is specifically depleted in sperm cells, is occupied by MET1-dependent CG methylation. Here, we show that MET1 confines ARID1 to the vegetative cell of male gametes, but ARID1 conversely represses MET1 in the central cell of female gametes. Compared to the vegetative cell-localization in wild type pollen, ARID1 expands to sperm cells in the met1 mutant...
August 7, 2017: Journal of Integrative Plant Biology
https://www.readbyqxmd.com/read/28782145/manometric-evaluation-of-the-motilin-receptor-agonist-camicinal-gsk962040-in-humans
#7
E Deloose, I Depoortere, J de Hoon, A Van Hecken, O E Dewit, L S Vasist Johnson, M E Barton, G E Dukes, J Tack
BACKGROUND: The gut hormone motilin stimulates gastrointestinal motility by inducing gastric phase III of the migrating motor complex (MMC) and enhancing the rate of gastric emptying. Camicinal (GSK962040), a small molecule motilin receptor agonist, has been shown to increase gastrointestinal motility. METHODS: In this proof of concept study the effects of camicinal on MMC activity, esophageal and gastric pH was evaluated in eight healthy volunteers as a secondary endpoint...
August 6, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/28777224/short-term-results-of-trabeculectomy-using-adjunctive-intracameral-bevacizumab-versus-mitomycin-c-a-randomized-controlled-trial
#8
Zakieh Vahedian, Mostafa Mafi, Ghasem Fakhraie, Reza Zarei, Yadollah Eslami, Hadi Ghadimi, Masomeh Mohebbi
PURPOSE: To compare the outcome of trabeculectomy using adjunctive intracameral bevacizumab versus intraoperative mitomycin C (MMC) MATERIALS AND METHODS:: In this double-blind, randomized clinical trial 87 eyes of 87 patients with primary open-angle or pseudoexfoliation glaucoma were assigned to each treatment group (44 cases received 1.25 mg intracameral bevacizumab at the end of operation and in 43 cases MMC was applied during surgery). Success was defined as intraocular pressure (IOP) between 6 and 21 mm Hg and at least 30% IOP drop with (qualified) or without (complete) glaucoma medications without additional glaucoma surgery...
August 2, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28769932/melanomacrophage-centers-as-a-histological-indicator-of-immune-function-in-fish-and-other-poikilotherms
#9
REVIEW
Natalie C Steinel, Daniel I Bolnick
Melanomacrophage centers (MMCs) are aggregates of highly pigmented phagocytes found primarily in the head kidney and spleen, and occasionally the liver of many vertebrates. Preliminary histological analyses suggested that MMCs are structurally similar to the mammalian germinal center (GC), leading to the hypothesis that the MMC plays a role in the humoral adaptive immune response. For this reason, MMCs are frequently described in the literature as "primitive GCs" or the "evolutionary precursors" to the mammalian GC...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28768252/amniotic-fluid-concentrations-of-glial-fibrillary-acidic-protein-do-not-correlate-with-prenatal-metrics-in-fetuses-with-myelomeningocele
#10
Aimee G Kim, Enrico Danzer, Julie S Moldenhauer, Nahla Khalek, Lauren E McClain, Lindsay N Waqar, Holly L Hedrick, Mark P Johnson, N Scott Adzick, William H Peranteau, Alan W Flake
INTRODUCTION: We investigated the correlation of amniotic fluid (AF) concentrations of glial fibrillary acidic protein (GFAP) with prenatal features of myelomeningocele (MMC) and neurodevelopmental outcome after fetal MMC (fMMC) surgery. MATERIALS AND METHODS: AF was collected during fMMC surgery between December 2012 and November 2015. AF-GFAP concentration was determined by ELISA. Retrospective chart review identified the characteristics of the defect. Data regarding delivery and 1-year neurodevelopmental outcome was collected from The Children's Hospital of Philadelphia fMMC Registry...
July 29, 2017: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/28762779/editorial-comment-on-end-2016-0871-or-r2-role-of-mitomycin-c-mmc-topical-treatment-for-upper-tract-urothelial-carcinoma-utuc
#11
Bhaskar K Somani
While adjuvant topical mitomycin C (MMC) is well established in realms of bladder cancer, its use in upper tract urothelial tumours (UTUC) is still somewhat limited with only few series reported worldwide. The authors present their series of 27 patients (28 renal units) on the role of adjuvant MMC after complete endoscopic control of UTUC with a median follow-up of 19 months (7-92 months). Their recurrence free survival of 62% at 3 years represents a medium term favourable result, especially in low-grade tumours...
August 1, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28755886/pharmacological-profile-of-mephedrone-analogs-and-related-new-psychoactive-substances
#12
REVIEW
Dino Luethi, Karolina E Kolaczynska, Luca Docci, Stephan Krähenbühl, Marius C Hoener, Matthias E Liechti
BACKGROUND: Mephedrone is a synthetic cathinone and one of the most popular recreationally used new psychoactive substances. The aim of the present study was to characterize the in vitro pharmacology of novel analogs of mephedrone and related newly emerged designer stimulants. METHODS: We determined norepinephrine, dopamine, and serotonin transporter inhibition potencies and monoamine release in transporter-transfected human embryonic kidney 293 cells. We also assessed monoamine receptor and transporter binding affinities...
July 26, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28743181/feasibility-and-safety-of-hyperthermic-intraperitoneal-chemotherapy-using-5-fluorouracil-combined-with-cisplatin-and-mitomycin-c-in-patients-undergoing-gastrectomy-for-advanced-gastric-cancer
#13
Satoshi Murata, Hiroshi Yamamoto, Hiroyuki Naitoh, Tsuyoshi Yamaguchi, Sachiko Kaida, Tomoharu Shimizu, Hisanori Shiomi, Shigeyuki Naka, Tohru Tani, Masaji Tani
BACKGROUND AND OBJECTIVES: We conducted a dose-finding study for 5-fluorouracil (5-FU) administered with cisplatin (CDDP) and mitomycin C (MMC) to find an improved regimen for hyperthermic intraperitoneal chemotherapy (HIPEC) for advanced gastric cancer (GC). METHODS: The appropriate HIPEC regimen previously determined in vitro was 5-FU (200 µg/mL), MMC (2 µg/mL), and CDDP (10 µg/mL) at hyperthermic conditions (42°C) for 30 min. This was a clinical study to determine the recommended dose of 5-FU in combination with MMC and CDDP at 42°C for 30 min and to evaluate HIPEC safety in patients at high risk of developing peritoneal metastases following GC surgery...
July 25, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28740605/synthesis-of-a-fluorescently-labeled-68-ga-dota-toc-analog-for-somatostatin-receptor-targeting
#14
Sukhen C Ghosh, Servando Hernandez Vargas, Melissa Rodriguez, Susanne Kossatz, Julie Voss, Kendra S Carmon, Thomas Reiner, Agnes Schonbrunn, Ali Azhdarinia
Fluorescently labeled imaging agents can identify surgical margins in real-time to help achieve complete resections and minimize the likelihood of local recurrence. However, photon attenuation limits fluorescence-based imaging to superficial lesions or lesions that are a few millimeters beneath the tissue surface. Contrast agents that are dual-labeled with a radionuclide and fluorescent dye can overcome this limitation and combine quantitative, whole-body nuclear imaging with intraoperative fluorescence imaging...
July 13, 2017: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28738986/pilot-testing-fall-tips-tailoring-interventions-for-patient-safety-a-patient-centered-fall-prevention-toolkit
#15
Patricia C Dykes, Megan Duckworth, Stephanie Cunningham, Sasha Dubois, Melissa Driscoll, Zinnia Feliciano, Michael Ferrazzi, Farah E Fevrin, Stephanie Lyons, Mary Ellen Lindros, Allison Monahan, Matthew M Paley, Saby Jean-Pierre, Maureen Scanlan
BACKGROUND: Patient falls during an acute hospitalization cause injury, reduced mobility, and increased costs. The laminated paper Fall TIPS Toolkit (Fall TIPS) provides clinical decision support at the bedside by linking each patient's fall risk assessment with evidence-based interventions. Strategies were needed to integrate this evidence into clinical practice. METHODS: The Institute for Healthcare Improvement's Framework for Spread is the conceptual model for pilot implementation of Fall TIPS at Brigham and Women's Hospital (BWH; Boston) and Montefiore Medical Center (MMC; Bronx, New York)...
August 2017: Joint Commission Journal on Quality and Patient Safety
https://www.readbyqxmd.com/read/28736644/overall-and-disease-free-survival-in-patients-treated-with-crs-hipec-with-cisplatin-and-paclitaxel-for-gastric-cancer-with-peritoneal-carcinomatosis
#16
Paola Fugazzola, Federico Coccolini, Giulia Montori, Marco Ceresoli, Paolo Baggi, Antonio Costanzo, Matteo Tomasoni, Francesco Gregis, Silvia Nozza, Luca Ansaloni
BACKGROUND: Our experience regarding cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) was reviewed in terms of overall survival (OS) and disease-free survival (DFS) in patients with synchronous peritoneal carcinomatosis (SPC) and metachronous peritoneal carcinomatosis (MPC) from gastric cancer (GC). METHODS: An analysis of prospectively collected data about patients who underwent CRS and HIPEC from July 2011 to July 2016 was carried out...
June 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28735714/internal-urethrotomy-with-intralesional-mitomycin-c-an-effective-option-for-endoscopic-management-of-recurrent-bulbar-and-bulbomembranous-urethral-strictures
#17
M Ryan Farrell, Cedric Lawrenz, Laurence A Levine
OBJECTIVE: To describe our experience with direct visual internal urethrotomy (DVIU) and mitomycin C (MMC) for recurrent bulbar/bulbomembranous urethral strictures of radiation and non-radiation induced etiologies. METHODS: We reviewed our database of consecutive patients presenting to our tertiary care institution with recurrent bulbar/bulbomembranous urethral strictures who underwent DVIU with MMC from 2011-2016. Patients were stratified by radiation-induced strictures (RIS) versus non-RIS...
July 20, 2017: Urology
https://www.readbyqxmd.com/read/28732618/predictors-of-myopic-photorefractive-keratectomy-retreatment
#18
Russell Pokroy, Michael Mimouni, Tzahi Sela, Gur Munzer, Igor Kaiserman
PURPOSE: To determine the factors associated with retreatment after photorefractive keratectomy (PRK) in myopic eyes. SETTING: Care-Vision Laser Centers, Tel-Aviv, Israel. DESIGN: Retrospective cohort study. METHODS: A large database on myopic PRK with mitomycin-C (MMC) performed from 2005 to 2012 was studied. Patients were divided into 2 groups according to whether they had retreatment. Multiple preoperative and intraoperative parameters were analyzed for association with retreatment...
June 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28731777/induction-and-maintenance-adjuvant-mitomycin-c-topical-therapy-for-upper-tract-urothelial-carcinoma-tolerability-and-intermediate-term-outcomes
#19
Michael Metcalfe, Gavin Wagenheim, Lianchun Xiao, John Papadopoulos, Neema Navai, John W Davis, Jose A Karam, Ashish M Kamat, Christopher G Wood, Colin P Dinney, Surena F Matin
PURPOSE: Endoscopic management of upper tract urothelial carcinoma (UTUC) is associated with higher recurrences, which could be reduced by application of topical therapy. Adjuvant induction Bacillus Calmette-Guerin has shown inferior outcomes for UTUC compared to bladder cancer, and maintenance regimens for UTUC are unexplored. We report on the efficacy, safety, and tolerability of Mitomycin C (MMC) induction and maintenance adjuvant topical therapy for UTUC. MATERIALS AND METHODS: Patients with UTUC who received adjuvant topical therapy after complete endoscopic control of Ta/T1 tumors were retrospectively reviewed...
July 21, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28721892/capecitabine-with-mitomycin-reduces-acute-hematologic-toxicity-and-treatment-delays-in-patients-undergoing-definitive-chemoradiation-using-intensity-modulated-radiation-therapy-for-anal-cancer
#20
Karyn A Goodman, Diana Julie, Andrea Cercek, Lajhem Cambridge, Kaitlin M Woo, Zhigang Zhang, Abraham J Wu, Diane L Reidy, Neil H Segal, Zsofia K Stadler, Leonard B Saltz
PURPOSE: To assess the impact on acute toxicity of replacing 5-fluorouracil (5-FU) with capecitabine in definitive chemoradiation for patients with anal squamous cell carcinoma (ASCC). METHODS AND MATERIALS: We retrospectively reviewed the records of 107 consecutive patients with nonmetastatic ASCC treated with definitive chemoradiation from January 2009 to May 2014. In 2011, based on the noninferiority of capecitabine versus 5-FU, our institutional practice shifted to use capecitabine instead of 5-FU for ASCC...
August 1, 2017: International Journal of Radiation Oncology, Biology, Physics
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