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https://www.readbyqxmd.com/read/28925963/on-the-role-of-processing-parameters-in-producing-recycled-aluminum-aa6061-based-metal-matrix-composite-mmc-alr-prepared-using-hot-press-forging-hpf-process
#1
Azlan Ahmad, Mohd Amri Lajis, Nur Kamilah Yusuf
Solid-state recycling, which involves the direct recycling of scrap metal into bulk material using severe plastic deformation, has emerged as a potential alternative to the conventional remelting and recycling techniques. Hot press forging has been identified as a sustainable direct recycling technique that has fewer steps and maintains excellent material performance. An experimental investigation was conducted to explore the hardness and density of a recycled aluminum-based metal matrix composite by varying operating temperature and holding time...
September 19, 2017: Materials
https://www.readbyqxmd.com/read/28921438/purification-methods-for-recombinant-factor-viii-expressed-in-human-liver-sk-hep-cells
#2
Vladimir Granovski, Mario Soares Abreu-Neto, Dimas Tadeu Covas
Coagulation factor VIII is one of the largest proteins attempted to be expressed in recombinant form. A very complex and labile protein which has a very short half-live and need a fast and efficient purification chain. Here, we describe a simple purification sequence using multimodal Capto MMC, affinity FVIII select and ion exchange SP-Fastflow chromatography steps without subjecting the target molecule to mechanical and temperature stress, separating impurities from rFVIII using net charge, hydrophobicity, and affinity of the molecules...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28910784/fetal-surgery-for-myelomeningocele-a-systematic-review-and-meta-analysis-of-outcomes-in-fetoscopic-versus-open-repair
#3
Sandra K Kabagambe, Guy W Jensen, Yue Julia Chen, Melissa A Vanover, Diana L Farmer
BACKGROUND/OBJECTIVES: The Management of Myelomeningocele (MMC) Study (MOMS) showed that prenatal repair of MMC resulted in improved neurological outcomes but was associated with high rates of obstetrical complications. This study compares outcomes of open and fetoscopic MMC repair. DATA SOURCES: PubMed and Embase studies reporting outcomes of fetal MMC repair published since the completion of the MOMS. RESULTS: We analyzed 11 studies and found no difference in mortality or the rate of shunt placement for hydrocephalus...
September 15, 2017: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/28901355/two-dimensional-metal-nacu6-3sb3-and-solid-state-transformations-of-sodium-copper-antimonides
#4
B Owens-Baird, S Lee, K Kovnir
A novel layered compound, NaCu6.3Sb3, has been successfully synthesized from elements. This unique structure crystallizes in the hexagonal space group P63/mmc and has lattice constants of a = 4.2166(2) Å and c = 24.041(1) Å. The structure consists of complex Cu/Sb 2D blocks separated by Na ions. These blocks contain graphene-like hexagonal layers of either Cu or CuSb. The solid-state transformations in the Na-Cu-Sb system between Cu2Sb-NaCu6.3Sb3-NaCu4Sb2 were explored using annealing at different partial vapor pressures of Na, differential scanning calorimetry, and in situ synchrotron powder X-ray diffraction...
September 13, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28901184/ex-vivo-pretreatment-of-islets-with-mitomycin-c-reduction-in-immunogenic-potential-of-islets-by-suppressing-secretion-of-multiple-chemotactic-factors
#5
Naoya Sato, Junichiro Haga, Takayuki Anazawa, Akira Kenjo, Takashi Kimura, Ikuo Wada, Tsutomu Mori, Shigeru Marubashi, Mitsukazu Gotoh
Strategies to reduce the immunogenicity of pancreatic islets and to prevent the activation of proinflammatory events are essential for successful islet engraftment. Pretransplant islet culture presents an opportunity for preconditioning to improve outcomes of islet transplantation. We previously demonstrated that ex vivo mitomycin C (MMC) pretreatment and subsequent culture significantly prolonged graft survival. Fully understanding the biological process of pretreatment could result in the development of a protocol to improve the survival of islet grafts...
August 2017: Cell Transplantation
https://www.readbyqxmd.com/read/28901019/isolation-and-characterization-of-pathogenic-vibrio-alginolyticus-from-sea-cage-cultured-cobia-rachycentron-canadum-linnaeus-1766-%C3%A2-in-india
#6
P Rameshkumar, A K A Nazar, M A Pradeep, C Kalidas, R Jayakumar, G Tamilmani, M Sakthivel, A K Samal, S Sirajudeen, V Venkatesan, B M Nazeera
Mass mortalities of cobia Rachycentron canadum sub-adults occurred during August 2013 in cage culture at the Gulf of Mannar, Mandapam Tamil Nadu, India. The epizootic of disease was started with typical classical clinical signs followed by the acute mortality. Grossly, severe haemorrhage and congestion was observed in the gastric mucosa. Abdomen was distended with peritoneal fluid. Heart revealed haemopericardium and fibrinous pericardium. Histologically, the gastric mucosa showed severe erosion and necrosis...
September 12, 2017: Letters in Applied Microbiology
https://www.readbyqxmd.com/read/28898400/intravesical-electromotive-drug-administration-for-non-muscle-invasive-bladder-cancer
#7
REVIEW
Jae Hung Jung, Ahmet Gudeloglu, Halil Kiziloz, Gretchen M Kuntz, Alea Miller, Badrinath R Konety, Philipp Dahm
BACKGROUND: Electromotive drug administration (EMDA) is the use of electrical current to improve the delivery of intravesical agents to reduce the risk of recurrence in people with non-muscle invasive bladder cancer (NMIBC). It is unclear how effective this is in comparison to other forms of intravesical therapy. OBJECTIVES: To assess the effects of intravesical EMDA for the treatment of NMIBC. SEARCH METHODS: We performed a comprehensive search using multiple databases (CENTRAL, MEDLINE, EMBASE), two clinical trial registries and a grey literature repository...
September 12, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28888117/biotransformation-antioxidant-and-histopathological-biomarker-responses-to-contaminants-in-european-and-american-yellow-eels-from-the-gironde-and-st-lawrence-estuaries
#8
Géraldine Patey, Catherine M Couillard, Fabien Pierron, Magalie Baudrimont, Patrice Couture
Since the early 1980s, populations of American (Anguilla rostrata) and European eels (Anguilla anguilla) have suffered a sharp decline. The causes of their decline are likely multifactorial and include chemical pollution. A field study was conducted in eight sites varying in organic and metal contamination along the St. Lawrence (Eastern Canada) and Gironde (France) systems to investigate the relationships among contaminants, biological characteristics and biotransformation, antioxidant and histopathological biomarkers in eels from both species...
August 28, 2017: Chemosphere
https://www.readbyqxmd.com/read/28886275/preclinical-rationale-for-combination-of-crizotinib-with-mitomycin-c-for-the-treatment-of-advanced-colorectal-cancer
#9
Avital Lev, Safoora Deihimi, Elena Shagisultanova, Joanne Xiu, Amriti R Lulla, David T Dicker, Wafik S El-Deiry
Colorectal cancer (CRC) is a leading cause of cancer-related deaths in the United States. We analyzed 26 MSI-High and 558 non-MSI-High CRC tumors. BRCA2 mutations were highly enriched (50%) in MSI-High CRC. Immunohistochemistry showed that BRCA2-mutated MSI-High CRC had high c-MET (64%) expression compared to BRCA-WT (17%). We hypothesized a mechanistic link between BRCA2-deficiency and c-MET overexpression and synergistic interaction between drugs that treat BRCA-deficient tumors (mitomycin C (MMC) or PARP inhibitors) and c-MET inhibitors (crizotinib)...
September 8, 2017: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/28885007/stereoselective-differences-between-the-reinforcing-and-motivational-effects-of-cathinone-derived-4-methylmethcathinone-mephedrone-in-self-administering-rats
#10
Helene L Philogene-Khalid, Steven J Simmons, Sunil Nayak, Rose M Martorana, Shu H Su, Yohanka Caro, Brona Ranieri, Kathryn DiFurio, Lili Mo, Taylor A Gentile, Ali Murad, Allen B Reitz, John W Muschamp, Scott M Rawls
Mephedrone (4-methylmethcathinone (4-MMC)) (MEPH) is a new psychoactive substance (NPS) of the synthetic cathinone class. MEPH has a chiral center and exists as two enantiomers (R-,S-MEPH), yet stereospecific effects of MEPH have not been extensively investigated in preclinical assays. Because significant behavioral and neurochemical differences can exist between enantiomers, probing effects of stereochemistry on biological activity enables separation of adverse and therapeutic effects. Our prior work showed that R-MEPH, relative to S-MEPH, produced greater locomotor activation, place preference and facilitation of brain reward thresholds in rodents...
September 8, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28876688/management-of-myelomeningocele-in-the-province-of-kwazulu-natal-south-africa
#11
M N Mnguni, B Enicker, T E Madiba
BACKGROUND: Spina bifida is the most common of congenital anomalies of the central nervous system that are compatible with life. The most frequent form is myelomeningocele. METHOD: Setting: Neurosurgery Unit, Inkosi Albert Luthuli Central Hospital. Patients: Consecutive children with diagnosis myelomeningocele who were managed at from January 2006 to December 2014. Design: Retrospective analysis of children with myelomeningocele. Multiple logistic regression analysis identified clinical, demographic and surgical variables that were associated with outcome...
June 2017: South African Journal of Surgery. Suid-Afrikaanse Tydskrif Vir Chirurgie
https://www.readbyqxmd.com/read/28874162/isolation-and-characterization-of-the-compounds-responsible-for-the-antimutagenic-activity-of-combretum-microphyllum-combretaceae-leaf-extracts
#12
Tshepiso Jan Makhafola, Esameldin Elzein Elgorashi, Lyndy Joy McGaw, Maurice Ducret Awouafack, Luc Verschaeve, Jacobus Nicolaas Eloff
BACKGROUND: Mutations play a major role in the pathogenesis and development of several chronic degenerative diseases including cancer. It follows, therefore that antimutagenic compound may inhibit the pathological process resulting from exposure to mutagens. Investigation of the antimutagenic potential of traditional medicinal plants and compounds isolated from plant extracts provides one of the tools that can be used to identify compounds with potential cancer chemopreventive properties...
September 6, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28871669/facilitated-subcutaneous-immunoglobulin-fscig-in-autoimmune-cytopenias-associated-with-common-variable-immunodeficiency
#13
Veronica Pedini, Isabella Savore, Giovanna Maria Danieli
BACKGROUND: Common variable immunodeficiency (CVID) is the most common symptomatic primary immune deficiency of adulthood. Besides recurrent infections, autoimmune disorders-mainly cytopenias-affect 30% of patients with CVID. OBJECTIVES: To describe the efficacy and safety of facilitated subcutaneous immunoglobulin (fSCIg), which is a combination of 10% [human] SCIg with recombinant human hyaluronidase for the treatment of CVID-linked cytopenias. METHODS: We describe four women (mean age 54 years) with CVID associated with idiopathic thrombocytopenic purpura (ITP) (n=3) and autoimmune hemolytic anemia (AIHA) (n=1)...
July 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28867320/complete-reversibility-of-the-chiari-type-ii-malformation-following-post-natal-repair-of-myelomeningocele
#14
P A Beuriat, A Szathmari, C Rousselle, I Sabatier, F di Rocco, C Mottolese
INTRODUCTION: It was believed that Chiari type II malformation (CM-II) was always present in a myelomeningocele (MMC). In fact, it is associated in about 80 % of cases. Improvement of the hindbrain herniation after prenatal closure of MMC has challenged the idea that this condition was irreversible. Only two studies report ascent of the cerebellar tonsil after post-natal closure. This work aimed to study a large group of MMC patients who benefitted from a post-natal repair to evaluate the rate of long-term total reversibility of CM-II...
August 31, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28866044/investigation-of-the-preventive-effect-of-sijunzi-decoction-on-mitomycin-c-induced-immunotoxicity-in-rats-by-1-h-nmr-and-ms-based-untargeted-metabolomic-analysis
#15
Zhibo Guan, Juan Wu, Cancan Wang, Fang Zhang, Yinan Wang, Miao Wang, Min Zhao, Chunjie Zhao
ETHNOPHARMACOLOGICAL RELEVANCE: Sijunzi decoction (SJZD) is a well known traditional Chinese prescription used for the treatment of gastrointestinal disorders and immunity enhancement. It has been found to indeed improve life quality of chemotherapy patients and extensive used in clinical conbined with chemotherapeutics for the treatment of cancer. AIM OF THE STUDY: The aim of this study was to investigate the preventive effect of the immunotoxicity of SJZD on mitomycin C (MMC) and the metabolic mechanism of action...
September 1, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28863940/new-mcm8-mutation-associated-with-premature-ovarian-insufficiency-and-chromosomal-instability-in-a-highly-consanguineous-tunisian-family
#16
Nouha Bouali, Bruno Francou, Jérôme Bouligand, Dilek Imanci, Sarra Dimassi, Lucie Tosca, Monia Zaouali, Soumaya Mougou, Jacques Young, Ali Saad, Anne Guiochon-Mantel
OBJECTIVE: To identify the gene(s) involved in the etiology of premature ovarian insufficiency in a highly consanguineous Tunisian family. DESIGN: Genetic analysis of a large consanguineous family with several affected siblings. SETTING: University hospital-based cytogenetics and molecular genetics laboratories. PATIENT(S): A highly consanguineous Tunisian family with several affected siblings born to healthy second-degree cousins...
August 29, 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28860912/causes-of-unsatisfactory-results-of-the-use-of-mitomycin-c-in-endoscopic-endonasal-dacryocystorhinostomy
#17
E L Atkova, A A Fedorov, A O Root, S D Iartsev, N N Krakhovetsky, V D Yartsev
PURPOSE: To study the antifibrotic effectiveness of mitomycin-C in the tissues of the ostium site after it application for endonasal endoscopic dacryocystorhinostomy. MATERIAL AND METHODS: The study included 45 patients (48 cases) with primary obstruction of the nasolacrimal duct. All patients underwent endoscopic endonasal dacryocystorhinostomy (EEDCR). At the final stage of the operation, a swab with MMC was placed in the region of the formed ostium at a concentration of 0...
July 2017: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
https://www.readbyqxmd.com/read/28860714/sensitization-of-gastric-cancer-cells-to-alkylating-agents-by-glaucocalyxin-b-via-cell-cycle-arrest-and-enhanced-cell-death
#18
Muhammad Saif Ur Rahman, Ling Zhang, Lingyan Wu, Yuqiong Xie, Chunchun Li, Jiang Cao
Severe side effects are major problems with chemotherapy of gastric cancer (GC). These side effects can be reduced by using sensitizing agents in combination with therapeutic drugs. In this study, the low/nontoxic dosage of glaucocalyxin B (GLB) was used with other DNA linker agents mitomycin C (MMC), cisplatin (DDP), or cyclophosphamide (CTX) to treat GC cells. Combined effectiveness of GLB with drugs was determined by proliferation assay. The molecular mechanisms associated with cell proliferation, migration, invasion, cell cycle, DNA repair/replication, apoptosis, and autophagy were investigated by immunoblotting for key proteins involved...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28858961/short-term-results-of-trabeculectomy-using-adjunctive-intracameral-bevacizumab-versus-mitomycin-c-a-randomized-controlled-trial
#19
Zakieh Vahedian, Mostafa Mafi, Ghasem Fakhraie, Reza Zarei, Yadollah Eslami, Hadi Ghadimi, Masomeh Mohebbi
PURPOSE: To compare the outcome of trabeculectomy using adjunctive intracameral bevacizumab versus intraoperative mitomycin C (MMC). MATERIALS AND METHODS: In this double-blind, randomized clinical trial 87 eyes of 87 patients with primary open-angle or pseudoexfoliation glaucoma were assigned to each treatment group (44 cases received 1.25 mg intracameral bevacizumab at the end of operation and in 43 cases MMC was applied during surgery). Success was defined as intraocular pressure (IOP) between 6 and 21 mm Hg and at least 30% IOP drop with (qualified) or without (complete) glaucoma medications without additional glaucoma surgery...
August 30, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28858151/posterior-surgical-revision-of-failed-fornix-based-trabeculectomy
#20
Doaa H Sobeih, Paul R Cotran
PURPOSE: To evaluate outcomes after revision of failed fornix-based trabeculectomy using a posterior conjunctival incision and Mitomycin C (MMC). METHODS: Cases were identified using Current Procedural Terminology codes. Information from clinical records was analyzed retrospectively. Complete success was defined as intraocular pressure (IOP) ≤16 mmHg with no glaucoma medications and IOP reduction of >20% from preoperative levels. Qualified success was defined as IOP ≤16 with or without medications and IOP reduction of >20%...
August 28, 2017: Journal of Glaucoma
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