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https://www.readbyqxmd.com/read/28225335/integrating-tuberculosis-screening-in-kenyan-prevention-of-mother-to-child-transmission-programs
#1
L M Cranmer, A Langat, K Ronen, C J McGrath, S LaCourse, J Pintye, B Odeny, B Singa, A Katana, L Nganga, J Kinuthia, G John-Stewart
BACKGROUND: Tuberculosis (TB) screening in Prevention of Mother-To-Child Transmission (PMTCT) programs is important to improve TB detection, prevention and treatment. METHODS: As part of a national PMTCT program evaluation, mother-infant pairs attending 6-week and 9-month immunization visits were enrolled at 141 maternal and child health clinics throughout Kenya. Clinics were selected using population-proportion-to-size sampling with oversampling in a high human immunodeficiency virus (HIV) prevalence region...
March 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/28199373/prevalence-of-maternal-hiv-infection-and-knowledge-on-mother-to-child-transmission-of-hiv-and-its-prevention-among-antenatal-care-attendees-in-a-rural-area-in-northwest-cameroon
#2
Carlson-Babila Sama, Vitalis F Feteh, Maxime Tindong, John T Tanyi, Nestor Mbinkar Bihle, Fru F Angwafo
BACKGROUND: In 2010, an estimated 141 new HIV infections occurred per day in Cameroon and reports suggest an upsurge of these rates by 2020 if current trends continue. Mother-to-child transmission (MTCT) of HIV is a major public health challenge, and maternal knowledge on HIV transmission during pregnancy and its prevention is important in curtailing paediatric HIV acquisition. OBJECTIVES: We aimed at establishing the prevalence of maternal HIV infection as well as assessing knowledge on HIV, MTCT and prevention of MTCT (PMTCT) of HIV among pregnant women in a rural area of Cameroon...
2017: PloS One
https://www.readbyqxmd.com/read/28198788/high-rates-of-baseline-drug-resistance-and-virologic-failure-among-art-na%C3%A3-ve-hiv-infected-children-in-mali
#3
Claudia S Crowell, Almoustapha I Maiga, Mariam Sylla, Babafemi Taiwo, Niaboula Kone, Assaf P Oron, Robert L Murphy, Anne-Geneviève Marcelin, Ban Traore, Djeneba B Fofana, Gilles Peytavin, Ellen G Chadwick
BACKGROUND: Limited data exist on drug resistance and antiretroviral treatment (ART) outcomes in HIV-1 infected children in West Africa. We determined the prevalence of baseline resistance and correlates of virologic failure (VF) in a cohort of ART naïve HIV-1 infected children <10 years of age initiating ART in Mali. METHODS: Reverse transcriptase and protease genes were sequenced at baseline (before ART) and at 6 months. Resistance was defined according to the Stanford HIV Genotypic Resistance database...
February 13, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28197845/correlation-of-adherence-by-pill-count-self-report-mems-and-plasma-drug-levels-to-treatment-response-among-women-receiving-arv-therapy-for-pmtct-in-kenya
#4
Victor Mudhune, Roman Gvetadze, Sonali Girde, Richard Ndivo, Frank Angira, Clement Zeh, Timothy Thomas, Shirley Lee Lecher
Success of antiretroviral therapy depends on adherence to effective treatment. We evaluated four adherence methods and their correlation with immunological and virologic response among women receiving PMTCT. Univariable and multivariable analyses were used to assess how adherence by pill count (n = 463), self-report (n = 463), MEMS (n = 129) and plasma drug level (n = 89) was associated with viral load suppression within a 6 months period. Longitudinal analysis was performed to determine the correlation of CD4 cell count with each measure of adherence...
February 14, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28181860/factors-associated-with-mother-to-child-transmission-of-hiv-despite-overall-low-transmission-rates-in-hiv-exposed-infants-in-rural-kenya
#5
Nicollate A Okoko, Kevin O Owuor, Jayne L Kulzer, George O Owino, Irene A Ogolla, Ronald W Wandera, Elizabeth A Bukusi, Craig R Cohen, Lisa L Abuogi
Despite the availability of efficacious prevention of mother-to-child transmission (PMTCT) interventions and improved access to preventive services in many developing countries, vertical HIV transmission persists. A matched case-control study of HIV-exposed infants between January and June 2012 was conducted at 20 clinics in Kenya. Cases were HIV-infected infants and controls were exposed, uninfected infants. Conditional logistic regression analysis was conducted to determine characteristics associated with HIV infection...
January 1, 2017: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/28173741/elimination-of-mother-to-child-transmission-of-hiv-lessons-learned-from-success-in-thailand
#6
Usa Thisyakorn
In 1988, the generalised HIV/AIDS epidemic in Thailand began and in the same year the first HIV-exposed infant in Thailand was born at King Chulalongkorn Memorial Hospital, Bangkok. From the early to mid-1990s, an epidemic wave of HIV-infected women and infants occurred. Heterosexual HIV transmission, as described in the Asian Epidemic Model, was the major mode of spread in Thailand, causing an increasing number of HIV-infected pregnant women. The early and concerted multi-sectoral response of Thai society reduced the prevalence of HIV infection in pregnant women from 2% in the mid-1990s to 0...
February 8, 2017: Paediatrics and International Child Health
https://www.readbyqxmd.com/read/28155303/female-perspectives-of-male-partners-inclusion-in-the-prevention-of-mother-to-child-hiv-transmission-programme-in-kwazulu-natal
#7
Mondli Miya, Tennyson Mgutshini
BACKGROUND: The South African government intervened by implementing the prevention of mother-to-child transmission programme (PMTCT) to curb the HIV transmission from mother to child during and after pregnancy. The PMTCT programme has been at the forefront of global prevention efforts since 1998. Without treatment, the risk of transmission ranges from one in five to one in two newborns; however, the risk of mother-to-child transmission can be reduced to as low as 2%-5% with evidenced interventions...
December 7, 2016: Curationis
https://www.readbyqxmd.com/read/28107227/structural-level-differences-in-the-mother-to-child-hiv-transmission-rate-in-south-africa-a-multilevel-assessment-of-individual-health-facility-and-provincial-level-predictors-of-infant-hiv-transmission
#8
S Woldesenbet, D J Jackson, C J Lombard, T H Dinh, V Ramokolo, T Doherty, G G Sherman, Y Pillay, A E Goga
OBJECTIVES: In 2010, South Africa reported an early mother to child transmission (MTCT) rate of 3.5% at 4-8 weeks postpartum. Provincial early MTCT rates ranged from 1.4% (95% confidence interval [CI]: 0.1-3.4%) to 5.9% (95% CI: 3.8-8.0%). We sought to determine reasons for these geographic differences in MTCT rates. METHODS: This study employed multilevel modelling using 2010 South African PMTCT evaluation (SAPMTCTE) data from 530 facilities. Interview data and infant blood samples were collected from 3085 mother-infant pairs at 4-8 weeks postpartum...
January 18, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28068675/nutrition-habits-and-health-outcomes-of-breastfeeding-hiv-positive-mothers-in-the-dschang-health-district-west-region-cameroon
#9
Martin Sanou Sobze, Tsi Kien-Atsu, Bruna Djeunang Dongho, Jimmy Roger Fotso, Armand TiotsiaTsapi, Yannick Azeufack Ngueko, Sali Ben Bechir, Augusto Pana, Lucia Ercoli, Vittorio Colizzi, Gianluca Russo
BACKGROUND: Amongst the different at-risk periods for mother-to-child HIV transmission that is, during pregnancy, labor and delivery and breastfeeding, much care and attention needs to be given, not only to the child as concerns its feeding options, but also to the mother. The aim of this study was to determine the nutritional habits and health outcomes of HIV-positive breastfeeding mothers in the Dschang Health District, in the context of prevention of mother-to-child transmission (PMTCT) activities...
September 2016: Igiene e Sanità Pubblica
https://www.readbyqxmd.com/read/28063074/prevention-of-mother-to-child-transmission-of-hiv-and-paediatric-hiv-care-and-treatment-monitoring-from-measuring-process-to-impact-and-elimination-of-mother-to-child-transmission-of-hiv
#10
Priscilla Idele, Chika Hayashi, Tyler Porth, Awandha Mamahit, Mary Mahy
Progress towards achievement of global targets for the prevention of mother-to-child transmission of HIV (PMTCT) and paediatric HIV care and treatment is an integral part of global and national HIV and AIDS responses. This paper documents the development of the global and national monitoring and reporting systems for PMTCT and paediatric HIV care and treatment programmes, achievements and remaining challenges. A review of the development of the monitoring and reporting process since 2002-2016 was conducted using existing published literature and taking into account changes in WHO HIV treatment guidelines, global HIV goals and targets, programmatic and methodological developments, and increased need for interagency partnerships, coordination and harmonization of global monitoring and reporting mechanisms...
January 6, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28049451/feasibility-study-of-hiv-sentinel-surveillance-using-pmtct-data-in-cameroon-from-scientific-success-to-programmatic-failure
#11
Serge C Billong, Jacob Dee, Joseph Fokam, Georges Nguefack-Tsague, Gabriel L Ekali, Raoul Fodjo, Edith S Temgoua, Edson-Joan Billong, Samuel M Sosso, Jembia J Mosoko, Francisca Monebenimp, Alexis Ndjolo, Anne-Cecile Z-K Bissek, Omotayo Bolu, Jean-Bosco N Elat
BACKGROUND: In low-income countries (LICs), HIV sentinel surveillance surveys (HIV-SSS) are recommended in between two demographic and health surveys, due to low-cost than the latter. Using the classical unlinked anonymous testing (UAT), HIV-SSS among pregnant women raised certain ethical and financial challenges. We therefore aimed at evaluating how to use prevention of mother-to-child transmission of HIV (PMTCT) routine data as an alternative approach for HIV-SSS in LICs. METHODS: A survey conducted through 2012 among first antenatal-care attendees (ANC1) in the ten regions of Cameroon...
January 3, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28046045/playing-the-catch-up-game-accelerating-the-scale-up-of-prevention-of-mother-to-child-transmission-of-hiv-pmtct-services-to-eliminate-new-pediatric-hiv-infection-in-nigeria
#12
Edward Adekola Oladele, Hadiza Khamofu, Seun Asala, Mariya Saleh, Uche Ralph-Opara, Charles Nwosisi, Chukwuma Anyaike, Catherine Gana, Oluwasanmi Adedokun, Rebecca Dirks, Olufunsho Adebayo, Modupe Oduwole, Justin Mandala, Kwasi Torpey
INTRODUCTION: As the world is making progress towards elimination of mother-to-child transmission of HIV, poor coverage of PMTCT services in Nigeria remains a major challenge. In order to address this, scale-up was planned with activities organized into 3 phases. This paper describes the process undertaken in eight high burden Nigerian states to rapidly close PMTCT coverage gaps at facility and population levels between February 2013 and March 2014. METHODS: Activities were grouped into three phases-pre-assessment phase (engagement of a wide range of stakeholders), assessment (rapid health facility assessment, a cross sectional survey using mixed methods conducted in the various states between Feb and May 2013 and impact modelling), and post-assessment (drawing up costed state operational plans to achieve eMTCT by 2015, data-driven smart scale-up)...
2017: PloS One
https://www.readbyqxmd.com/read/28045712/exploring-the-experiences-of-women-and-health-care-workers-in-the-context-of-pmtct-option-b-plus-in-malawi
#13
Fabian Cataldo, Levison Chiwaula, Misheck Nkhata, Monique van Lettow, Florence Kasende, Nora E Rosenberg, Hannock Tweya, Veena Sampathkumar, Mina Hosseinipour, Erik Schouten, Atupele Kapito-Tembo, Michael Eliya, Frank Chimbwandira, Sam Phiri
INTRODUCTION: Malawi has embarked on a 'test-and-treat' approach to prevent mother-to-child transmission of HIV (PMTCT), known as 'Option B+', offering all HIV-infected pregnant and breastfeeding women lifelong antiretroviral treatment (ART) regardless of CD4-count or clinical stage. We conducted a cross-sectional qualitative study to explore early experiences surrounding 'Option B+' for patients and health care workers (HCWs) in Malawi. METHODS: Study participants were purposively selected across six health facilities in three regional health zones in Malawi...
December 9, 2016: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28027287/despite-access-to-antiretrovirals-for-prevention-and-treatment-high-rates-of-mortality-persist-among-hiv-infected-infants-and-young-children
#14
Elaine J Abrams, Selamawit Woldesenbet, Juliana Soares Silva, Ashraf Coovadia, Viviane Black, Karl-Günter Technau, Louise Kuhn
BACKGROUND: Outcomes of HIV-infected children before widespread use of antiretroviral therapy (ART) for treatment and prevention of mother-to-child transmission (PMTCT) have been well characterized but less is known about children who acquire HIV infection in the context of good ART access. METHODS: We enrolled newly-diagnosed HIV-infected children <24 months (mos) of age at 3 hospitals and 2 clinics in Johannesburg, South Africa. We report ART initiation and mortality rates during 6 months from enrollment and factors associated with mortality...
December 23, 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28006001/detectable-viral-load-in-late-pregnancy-among-women-in-the-rwanda-option-b-pmtct-program-enrollment-results-from-the-kabeho-study
#15
Michelle M Gill, Heather J Hoffman, Emily A Bobrow, Placidie Mugwaneza, Dieudonne Ndatimana, Gilles F Ndayisaba, Cyprien Baribwira, Laura Guay, Anita Asiimwe
There are limited viral load (VL) data available from programs implementing "Option B+," lifelong antiretroviral treatment (ART) to all HIV-positive pregnant and postpartum women, in resource-limited settings. Extent of viral suppression from a prevention of mother-to-child transmission of HIV program in Rwanda was assessed among women enrolled in the Kigali Antiretroviral and Breastfeeding Assessment for the Elimination of HIV (Kabeho) Study. ARV drug resistance testing was conducted on women with VL>2000 copies/ml...
2016: PloS One
https://www.readbyqxmd.com/read/28002994/implementation-of-the-prevention-of-mother-to-child-transmission-pmtct-program-in-the-northern-cape-south-africa
#16
Bianca Myburgh, Riette Nel, Ronette Lategan-Potgieter
BACKGROUND: South Africa's Prevention of Mother-to-Child Transmission (PMTCT) of Human Immunodeficiency Virus (HIV) program has been implemented for over ten years. This has led to a considerable reduction in mother-to-child transmissions. In 2010, the Northern Cape Province had a 1.4% transmission rate, being the lowest in the country. OBJECTIVE: To describe the implementation of the PMTCT program in the Frances Baard district, Northern Cape Province; South Africa and identify factors that may influence the effectiveness of this program...
December 21, 2016: Current HIV Research
https://www.readbyqxmd.com/read/27999070/alarming-increase-in-pretreatment-hiv-drug-resistance-in-children-living-in-sub-saharan-africa-a-systematic-review-and-meta-analysis
#17
R S Boerma, K C E Sigaloff, A S Akanmu, S Inzaule, M Boele van Hensbroek, T F Rinke de Wit, J C Calis
BACKGROUND: Children have an augmented risk of pretreatment HIV drug resistance (PDR) due to exposure to antiretroviral drugs for the prevention of mother-to-child transmission (PMTCT). Paediatric data are essential to evaluate the effectiveness of the restricted number of paediatric regimens currently available, but these data are scarce. METHODS: We conducted a systematic review of the literature on PDR in children (median age ≤12 years) in sub-Saharan Africa...
December 20, 2016: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/27933462/what-do-you-need-to-get-male-partners-of-pregnant-women-tested-for-hiv-in-resource-limited-settings-the-baby-shower-cluster-randomized-trial
#18
Echezona E Ezeanolue, Michael C Obiefune, Wei Yang, Chinenye O Ezeanolue, Jennifer Pharr, Alice Osuji, Amaka G Ogidi, Aaron T Hunt, Dina Patel, Gbenga Ogedegbe, John E Ehiri
Male partner involvement has the potential to increase uptake of interventions to prevent mother-to-child transmission of HIV (PMTCT). Finding cultural appropriate strategies to promote male partner involvement in PMTCT programs remains an abiding public health challenge. We assessed whether a congregation-based intervention, the Healthy Beginning Initiative (HBI), would lead to increased uptake of HIV testing among male partners of pregnant women during pregnancy. A cluster-randomized controlled trial of forty churches in Southeastern Nigeria randomly assigned to either the HBI (intervention group; IG) or standard of care referral to a health facility (control group; CG) was conducted...
February 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/27893488/pregnancy-and-hiv-disease-progression-in-an-early-infection-cohort-from-five-african-countries
#19
Kristin M Wall, Wasima Rida, Lisa B Haddad, Anatoli Kamali, Etienne Karita, Shabir Lakhi, William Kilembe, Susan Allen, Mubiana Inambao, Annie H Yang, Mary H Latka, Omu Anzala, Eduard J Sanders, Linda-Gail Bekker, Vinodh A Edward, Matt A Price
BACKGROUND: Understanding associations between pregnancy and HIV disease progression is critical to provide appropriate counseling and care to HIV-positive women. METHODS: From 2006 to 2011, women less than age 40 with incident HIV infection were enrolled in an early HIV infection cohort in Kenya, Rwanda, South Africa, Uganda, and Zambia. Time-dependent Cox models evaluated associations between pregnancy and HIV disease progression. Clinical progression was defined as a single CD4 measurement <200 cells/μl, percent CD4 <14%, or category C event, with censoring at antiretroviral (ART) initiation for reasons other than prevention of mother-to-child transmission (PMTCT)...
March 2017: Epidemiology
https://www.readbyqxmd.com/read/27875363/pmtct-option-b-does-not-increase-preterm-birth-risk-and-may-prevent-extreme-prematurity-a-retrospective-cohort-study-in-malawi
#20
Maganizo B Chagomerana, William C Miller, Brian W Pence, Mina C Hosseinipour, Irving F Hoffman, Robert J Flick, Hannock Tweya, Soyapi Mumba, Frank Chimbwandira, Kimberly A Powers
OBJECTIVE: To estimate preterm birth risk among infants of HIV-infected women in Lilongwe, Malawi, according to maternal antiretroviral therapy (ART) status and initiation time under Option B+. DESIGN: A retrospective cohort study of HIV-infected women delivering at ≥27 weeks of gestation, April 2012 to November 2015. Among women on ART at delivery, we restricted our analysis to those who initiated ART before 27 weeks of gestation. METHODS: We defined preterm birth as a singleton live birth at ≥27 and <37 weeks of gestation, with births at <32 weeks classified as extremely to very preterm...
April 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
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