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https://www.readbyqxmd.com/read/27893488/pregnancy-and-hiv-disease-progression-in-an-early-infection-cohort-from-five-african-countries
#1
Kristin M Wall, Wasima Rida, Lisa Haddad, Anatoli Kamali, Etienne Karita, Shabir Lakhi, William Kilembe, Susan Allen, Mubiana Inambao, Annie H Yang, Mary H Latka, Omu Anzala, Eduard J Sanders, Linda-Gail Bekker, Vinodh A Edward, Matt A Price
BACKGROUND: Understanding associations between pregnancy and HIV disease progression is critical to providing appropriate counseling and care to HIV-positive women. METHODS: From 2006-2011, women under age 40 with incident HIV infection were enrolled in an early HIV infection cohort in Kenya, Rwanda, South Africa, Uganda, and Zambia. Time-dependent Cox models evaluated associations between pregnancy and HIV disease progression. Clinical progression was defined as a single CD4 measurement <200 cells/μL, percent CD4 <14%, or category C event, with censoring at antiretroviral (ART) initiation for reasons other than prevention of mother-to-child transmission (PMTCT)...
November 22, 2016: Epidemiology
https://www.readbyqxmd.com/read/27875363/pmtct-option-b-does-not-increase-preterm-birth-risk-and-may-prevent-extreme-prematurity-a-retrospective-cohort-study-in-malawi
#2
Maganizo B Chagomerana, William C Miller, Brian W Pence, Mina C Hosseinipour, Irving F Hoffman, Robert J Flick, Hannock Tweya, Soyapi Mumba, Frank Chibwandira, Kimberly A Powers
OBJECTIVE: To estimate preterm birth risk among infants of HIV-infected women in Lilongwe, Malawi according to maternal antiretroviral therapy (ART) status and initiation time under Option B+. DESIGN: Retrospective cohort study of HIV-infected women delivering at ≥27 weeks of gestation, April 2012-November 2015. Among women on ART at delivery, we restricted our analysis to those who initiated ART before 27 weeks of gestation. METHODS: We defined preterm birth as a singleton live birth at ≥27 and <37 weeks of gestation, with births at <32 weeks classified as extremely to very preterm...
November 21, 2016: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/27872760/factors-associated-with-pmtct-cascade-completion-in-four-african-countries
#3
Jodie Dionne-Odom, Thomas K Welty, Andrew O Westfall, Benjamin H Chi, Didier Koumavi Ekouevi, Margaret Kasaro, Pius M Tih, Alan T N Tita
Background. Many countries are working to reduce or eliminate mother-to-child transmission (MTCT) of HIV. Prevention efforts have been conceptualized as steps in a cascade but cascade completion rates during and after pregnancy are low. Methods. A cross-sectional survey was performed across 26 communities in Cameroon, Cote d'Ivoire, South Africa, and Zambia. Women who reported a pregnancy within two years were enrolled. Participant responses were used to construct the PMTCT cascade with all of the following steps required for completion: at least one antenatal visit, HIV testing performed, HIV testing result received, initiation of maternal prophylaxis, and initiation of infant prophylaxis...
2016: AIDS Research and Treatment
https://www.readbyqxmd.com/read/27865052/retention-in-care-and-reasons-for-discontinuation-of-lifelong-antiretroviral-therapy-in-a-cohort-of-cameroonian-pregnant-and-breastfeeding-hiv-positive-women-initiating-option-b-in-the-south-west-region
#4
Pascal N Atanga, Harrison T Ndetan, Eric A Achidi, Henry D Meriki, Michael Hoelscher, Arne Kroidl
OBJECTIVE: To assess linkage and retention in care along the PMTCT cascade in HIV-positive pregnant and breastfeeding women initiating Option B+ in Cameroon. METHODS: We prospectively determined uptake of HIV testing and counselling (HTC), uptake of ART and retention in care after Option B+ initiation between October 2013 and December 2014 in pregnant and breastfeeding women from five sites within the Kumba Health District. Retention in care was assessed over at least 12 months follow-up and estimated by Kaplan Meier analysis...
November 16, 2016: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/27846070/implementation-and-operational-research-an-integrated-and-comprehensive-service-delivery-model-to-improve-pediatric-and-maternal-hiv-care-in-rural-africa
#5
Anna Gamell, Tracy R Glass, Lameck B Luwanda, Herry Mapesi, Leila Samson, Tom Mtoi, Angelo Nyamtema, Lukas Muri, Alex Ntamatungiro, Marcel Tanner, Christoph Hatz, Manuel Battegay, Emilio Letang
BACKGROUND: Strategies to improve HIV diagnosis and linkage into care, antiretroviral treatment coverage, and treatment outcomes of mothers and children are urgently needed in sub-Saharan Africa. METHODS: From December 2012, we implemented an intervention package to improve prevention of mother-to-child transmission (PMTCT) and pediatric HIV care in our rural Tanzanian clinic, consisting of: (1) creation of a PMTCT and pediatric unit integrated within the reproductive and child health clinic; (2) implementation of electronic medical records; (3) provider-initiated HIV testing and counseling in the hospital wards; and (4) early infant diagnosis test performed locally...
December 15, 2016: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/27836020/high-levels-of-pre-treatment-hiv-drug-resistance-and-treatment-failure-in-nigerian-children
#6
Ragna S Boerma, T Sonia Boender, Kim C E Sigaloff, Tobias F Rinke de Wit, Michael Boele van Hensbroek, Nicaise Ndembi, Titilope Adeyemo, Edamisan O Temiye, Akin Osibogun, Pascale Ondoa, Job C Calis, Alani Sulaimon Akanmu
INTRODUCTION: Pre-treatment HIV drug resistance (PDR) is an increasing problem in sub-Saharan Africa. Children are an especially vulnerable population to develop PDR given that paediatric second-line treatment options are limited. Although monitoring of PDR is important, data on the paediatric prevalence in sub-Saharan Africa and its consequences for treatment outcomes are scarce. We designed a prospective paediatric cohort study to document the prevalence of PDR and its effect on subsequent treatment failure in Nigeria, the country with the second highest number of HIV-infected children in the world...
2016: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/27829490/strategies-to-improve-male-involvement-in-pmtct-option-b-in-four-african-countries-a-qualitative-rapid-appraisal
#7
Donela Besada, Sarah Rohde, Ameena Goga, Nika Raphaely, Emmanuelle Daviaud, Vundli Ramokolo, Vuyolwethu Magasana, Nobuntu Noveve, Tanya Doherty
BACKGROUND: The World Health Organization recommends that antiretroviral therapy be started as soon as possible, irrespective of stage of HIV infection. This 'test and treat' approach highlights the need to ensure that men are involved in prevention of mother-to-child HIV transmission (PMTCT). This article presents findings from a rapid appraisal of strategies to increase male partner involvement in PMTCT services in Uganda, Democratic Republic of Congo, Malawi, and Côte d'Ivoire in the context of scale-up of Option B+ protocol...
2016: Global Health Action
https://www.readbyqxmd.com/read/27819151/depression-retention-in-care-and-uptake-of-pmtct-service-in-kinshasa-the-democratic-republic-of-congo-a-prospective-cohort
#8
Kelly A Yotebieng, Kunuwo Fokong, Marcel Yotebieng
There is a clear need for effective strategies to address the factors that affect retention, or lost-to-follow-up (LTFU) and adherence to HIV care and treatment. Depression in particular may play an important role in the high rates of LTFU along the prevention of mother-to-child HIV transmission (PMTCT) cascade in sub-Saharan Africa. This study assessed the association between prenatal depression and (1) LTFU or (2) uptake of PMTCT services. As part of a randomized control trial to evaluate the effect of conditional cash transfers on retention in and uptake of PMTCT services, newly diagnosed HIV-infected women, ≤32 weeks pregnant, registering for antenatal care (ANC), in 85 clinics in Kinshasa, Democratic Republic of Congo (DRC), were recruited and followed-up until LTFU, death, transfer out, or six weeks postpartum...
November 6, 2016: AIDS Care
https://www.readbyqxmd.com/read/27800094/male-involvement-in-pmtct-and-associated-factors-among-men-whom-their-wives-had-anc-visit-12-months-prior-to-the-study-in-gondar-town-north-west-ethiopia-december-2014
#9
Abdella Amano, Abdulbasit Musa
INTRODUCTION: Globally, male involvement has been recognized as a priority focus area to be strengthened in PMTCT but, testing male partners for HIV in the context of preventing mother-to-child transmission remains a challenge in most low- and middle-income countries including Ethiopia. In Ethiopia even though male involvement is one of the guiding principle in testing and counseling of HIV, the magnitude of male involvement in PMTCT is not well known. The objective was to assess the magnitude of male involvement in PMTCT and associated factors among men whom their wives have ANC visit 12 months prior to the study in Gondar town, North west Ethiopia...
2016: Pan African Medical Journal
https://www.readbyqxmd.com/read/27798004/cohort-profile-the-hlabisa-pregnancy-cohort-kwazulu-natal-south-africa
#10
Terusha Chetty, Claire Thorne, Frank Tanser, Till Bärnighausen, Anna Coutsoudis
PURPOSE: The Hlabisa pregnancy cohort was established to evaluate the effectiveness of prevention of mother-to-child transmission (PMTCT) guideline revisions. The objectives of the Hlabisa pregnancy cohort are to: (1) provide cohort-level information on maternal health up to 6 weeks postpartum in a high HIV prevalence setting; and to (2) evaluate aspects of PMTCT care that have policy relevance. PARTICIPANTS: The pregnancy cohort is located in primary health clinics in the Hlabisa subdistrict of rural KwaZulu-Natal, South Africa...
October 17, 2016: BMJ Open
https://www.readbyqxmd.com/read/27796131/maternal-highly-active-antiretroviral-therapy-reduces-vertical-cytomegalovirus-transmission-but-does-not-reduce-breast-milk-cytomegalovirus-levels
#11
Jennifer A Slyker, Barbra Richardson, Michael H Chung, Claire Atkinson, Kristjana H Ásbjörnsdóttir, Dara A Lehman, Michael Boeckh, Vincent Emery, James Kiarie, Grace John-Stewart
OBJECTIVE: To evaluate the impact of highly active antiretroviral therapy (HAART) on CMV transmission and breast milk level in the context of maternal HIV. DESIGN: Specimens from a randomized trial conducted in Nairobi, Kenya between 2003-2005 were used to compare CMV transmission and breast milk levels between mother-infant pairs randomized to HAART versus short-course antenatal zidovudine plus single-dose nevirapine (ZDV/sdNVP) for prevention of mother-to-child HIV transmission (PMTCT)...
December 6, 2016: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/27787342/conditional-cash-transfers-improve-retention-in-pmtct-services-by-mitigating-the-negative-effect-of-not-having-money-to-come-to-the-clinic
#12
Marcel Yotebieng, Kathryn E Moracco, Harsha Thirumurthy, Andrew Edmonds, Martine Tabala, Bienvenu Kawende, Landry Kipula Wenzi, Emile W Okitolonda, Frieda Behets
OBJECTIVE: To elucidate the mechanisms by which a cash incentive intervention increases retention in prevention of mother-to-child transmission (PMTCT) services. METHODS: We used data from a randomized controlled trial in Kinshasa, Democratic Republic of Congo. Perceptual factors associated with loss-to-follow-up (LTFU) through six weeks postpartum were first identified. Then, binomial models were used to assess interactions between LTFU and identified factors, and the cash incentive intervention...
October 24, 2016: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/27776495/lessons-learned-from-the-pmtct-program-in-swaziland-challenges-with-accepting-lifelong-art-for-pregnant-and-lactating-women-a-qualitative-study
#13
Leila Katirayi, Caspian Chouraya, Kwashie Kudiabor, Mohammed Ali Mahdi, Mary Pat Kieffer, Karen Marie Moland, Thorkild Tylleskar
BACKGROUND: Swaziland has one of the highest HIV prevalence rates in sub-Saharan Africa, 26 % of the adult population is infected with HIV. The prevalence is highest among pregnant women, at 41.1 %. According to Swaziland's prevention of mother-to-child transmission (PMTCT) guidelines, approximately 50 % of pregnant women are eligible for antiretroviral therapy (ART) by CD4 criteria (<350 cells/ml). Studies have shown that most mother-to-child transmission and postnatal deaths occur among women who are eligible for ART...
October 24, 2016: BMC Public Health
https://www.readbyqxmd.com/read/27776040/the-effects-of-hiv-on-fertility-by-infection-duration-evidence-from-african-population-cohorts-before-art-availability-fertility-by-duration-of-hiv-infection
#14
Milly Marston, Jessica Nakiyingi-Miiro, Sylvia Kusemererwa, Mark Urassa, Denna Michael, Constance Nyamukapa, Simon Gregson, Basia Zaba, Jeffrey W Eaton
OBJECTIVES: To estimate the relationship between HIV natural history and fertility by duration of infection in East and Southern Africa before the availability of antiretroviral therapy, and assess potential biases in estimates of age-specific sub-fertility when using retrospective birth histories in cross-sectional studies. DESIGN: Pooled analysis of prospective population-based HIV cohort studies in Masaka (Uganda) Kisesa (Tanzania), and Manicaland (Zimbabwe)...
October 20, 2016: AIDS
https://www.readbyqxmd.com/read/27768731/predictors-of-patient-dissatisfaction-with-services-for-prevention-of-mother-to-child-transmission-of-hiv-in-dar-es-salaam-tanzania
#15
Helga Naburi, Phares Mujinja, Charles Kilewo, Till Bärnighausen, Nicola Orsini, Karim Manji, Gunnel Biberfeld, David Sando, Pascal Geldsetzer, Guerino Chalamila, Anna Mia Ekström
BACKGROUND: Mother-to-child transmission (MTCT) of HIV remains a major source of new HIV infections in children. Prevention of mother-to-child transmission of HIV (PMTCT) using lifelong antiretroviral treatment (ART) for all pregnant and breastfeeding women living with HIV (Option B+) is the major strategy for eliminating paediatric HIV. Ensuring that patients are satisfied with PMTCT services is important for optimizing uptake, adherence and retention in treatment. METHODS: We conducted a facility based quantitative cross-sectional survey in Dar-es-Salaam, Tanzania, between March and April 2014, when the country was transitioning to the implementation of PMTCT Option B+...
2016: PloS One
https://www.readbyqxmd.com/read/27757019/scale-up-use-of-family-planning-services-to-prevent-maternal-transmission-of-hiv-among-discordant-couples-a-cross-sectional-study-within-a-resource-limited-setting
#16
Martin Kuete, HongFang Yuan, Aude Laure Tchoua Kemayou, Emmanuel Ancel Songo, Fan Yang, XiuLan Ma, ChengLiang Xiong, HuiPing Zhang
BACKGROUND: Integration of family planning services (FPS) into human immunodeficiency virus (HIV) care for HIV-infected women is an important aspect of the global prevention of mother-to-child transmission (PMTCT) strategy. We assessed the integration of FPS into routine care of HIV-infected mothers by evaluating the uptake and barriers of contraception and PMTCT services. METHODS: We conducted an interventional study using the interrupted time series approach in the health care facilities located in Yaounde, Cameroon...
2016: Patient Preference and Adherence
https://www.readbyqxmd.com/read/27753679/costs-along-the-service-cascades-for-hiv-testing-and-counselling-and-prevention-of-mother-to-child-transmission
#17
Sergio Bautista-Arredondo, Sandra G Sosa-Rubí, Marjorie Opuni, David Contreras-Loya, Ada Kwan, Claire Chaumont, Abson Chompolola, Jeanine Condo, Omar Galárraga, Neil Martinson, Felix Masiye, Sabin Nsanzimana, Ivan Ochoa-Moreno, Richard Wamai, Joseph Wang'ombe
OBJECTIVE: We estimate facility-level average annual costs per client along the HIV testing and counselling (HTC) and prevention of mother-to-child transmission (PMTCT) service cascades. DESIGN: Data collected covered the period 2011-2012 in 230 HTC and 212 PMTCT facilities in Kenya, Rwanda, South Africa, and Zambia. METHODS: Input quantities and unit prices were collected, as were output data. Annual economic costs were estimated from the service providers' perspective using micro-costing...
October 23, 2016: AIDS
https://www.readbyqxmd.com/read/27749662/perinatal-antiretroviral-exposure-and-prevented-mother-to-child-hiv-infections-in-the-era-of-antiretroviral-prophylaxis-in-the-united-states-1994-2010
#18
Kristen M Little, Allan W Taylor, Craig B Borkowf, Maria C B Mendoza, Margaret A Lampe, Paul J Weidle, Steven R Nesheim
OBJECTIVE: Using published, nationally representative estimates, we calculated the total number of perinatally HIV-exposed and -infected infants born during 1978-2010, the number of perinatal HIV cases prevented by interventions designed for the prevention of mother-to-child transmission (PMTCT), and the number of infants exposed to antiretroviral drugs during the prenatal and intrapartum periods. DESIGN: We calculated the number of infants exposed to antiretroviral drugs since 1994, and the number of cases of mother-to-child HIV transmission prevented from 1994-2010 using published data...
September 30, 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27734167/understanding-the-adolescent-gap-in-hiv-testing-among-clients-of-antenatal-care-services-in-west-and-central-african-countries
#19
Stephane Helleringer
New HIV infections among children have declined significantly more slowly in West and central African countries (WCA) than in eastern and southern African countries between 2009 and 2015. Since adolescent fertility is particularly high in WCA countries, frequent mother-to-child transmission (MTCT) of HIV may in part be due to low coverage of HIV testing among adolescents during antenatal care (ANC). We investigated this adolescent gap in HIV testing using survey data from the demographic and health surveys and multiple indicators cluster surveys collected in 21 WCA countries since 2009...
October 12, 2016: AIDS and Behavior
https://www.readbyqxmd.com/read/27733034/level-of-adherence-and-associated-factors-to-option-b-pmtct-among-pregnant-and-lactating-mothers-in-selected-government-health-facilities-of-south-wollo-zone-amhara-region-north-east-ethiopia-2016
#20
Delelegn Tsegaye, Leul Deribe, Shambel Wodajo
Objectives: Adherence of HIV positive pregnant and lactating mothers to ART is a central component in PMTCT. Thus, the aim of this study was to measure the level of adherence and identify factors associated with adherence to option B+ PMTCT among pregnant and lactating mothers in selected government health facilities of South Wollo Zone, Amhara region, North East Ethiopia. Methods: An institution based cross sectional quantitative study design was employed from March 1 to April 14, 2016 using standard structured data collection instrument...
October 13, 2016: Epidemiology and Health
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