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https://www.readbyqxmd.com/read/28812457/from-half-dead-to-being-free-resistance-to-hiv-stigma-self-disclosure-and-support-for-pmtct-hiv-care-among-couples-living-with-hiv-in-kenya
#1
Sydney A Spangler, Lisa L Abuogi, Eliud Akama, Elizabeth A Bukusi, Anna Helova, Pamela Musoke, Wafula Z Nalwa, Thomas A Odeny, Maricianah Onono, Iris Wanga, Janet M Turan
In sub-Saharan Africa, self-disclosure of HIV-positive status may be a pivotal action for improving access to prevention of mother-to-child transmission services. However, understanding of HIV stigma and disclosure, and their effects on demand for care remains incomplete - particularly in the current context of new antiretroviral therapy guidelines. The purpose of this study was to explore these issues among self-disclosed couples living in southwest Kenya. We conducted 38 in-depth interviews with HIV-positive pregnant or postpartum women and their male partners...
August 16, 2017: Culture, Health & Sexuality
https://www.readbyqxmd.com/read/28810669/hiv-status-disclosure-facility-based-delivery-and-postpartum-retention-of-mothers-in-a-prevention-clinical-trial-in-rural-nigeria
#2
Kidane A Sarko, Meridith Blevins, Aimalohi A Ahonkhai, Carolyn M Audet, Troy D Moon, Usman I Gebi, Ahmed M Gana, C William Wester, Sten H Vermund, Muktar H Aliyu
Background: Within the context of a cluster randomized prevention of mother-to-child HIV transmission (PMTCT) trial, we evaluated the impact of disclosure on selected PMTCT continuum of care measures. Methods: In 12 rural matched-pair clinics randomly assigned to an intervention package versus standard-of-care, we enrolled 372 HIV-infected pregnant women from April 2013 to March 2014. This secondary analysis included 327 (87.9%) women with unknown HIV status or who were treatment naïve at presentation to antenatal care...
July 1, 2017: International Health
https://www.readbyqxmd.com/read/28798891/hiv-positive-women-taking-lifelong-antiretroviral-therapy-report-better-adherence-than-women-taking-short-course-prophylaxis-during-and-after-pregnancy-under-pmtct-program-option-a-in-lusaka-zambia
#3
Karen M Hampanda, Lisa L Abuogi, Yusuf Ahmed
BACKGROUND AND OBJECTIVES: HIV-positive women's adherence to antiretrovirals is critical for prevention of mother-to-child transmission. We aimed to establish if mothers taking triple lifelong antiretroviral therapy report higher adherence compared to mothers taking short-course prophylaxis under Option A in Lusaka, Zambia. METHODS: In this clinic-based cross-sectional study, we interviewed 320 HIV-positive mothers at a large public health facility in Lusaka in 2014...
2017: International Journal of MCH and AIDS
https://www.readbyqxmd.com/read/28797181/hiv-resistance-with-correlation-to-pmtct-regimen-in-hiv-infected-infants-in-northern-tanzania
#4
Dorothy Elizabeth Dow, Werner Schimana, Balthazar M Nyombi, Blandina T Mmbaga, Aisa M Shayo, John A Bartlett, Charles G Massambu, Emmanuel G Kifaro, Elizabeth L Turner, Todd DeMarco, Fangping Cai, Coleen Cunningham, Ann M Buchanan
Prevention of mother-to-child transmission (PMTCT) guidelines recommend that all HIV-infected pregnant woman receive antiretroviral therapy (Option B) and HIV-infected infants should initiate therapy with a protease inhibitor based regimen; however, implementation of these guidelines has lagged in many resource-limited settings. Tanzania only recently implemented these guidelines with little country specific data to inform whether HIV non-nucleoside reverse transcriptase inhibitor (NNRTI) resistance was present among infected infants under the Option A guidelines...
August 11, 2017: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/28782334/pregnant-adolescents-living-with-hiv-what-we-know-what-we-need-to-know-where-we-need-to-go
#5
Tegan Callahan, Surbhi Modi, Jennifer Swanson, Bernadette Ng'eno, Laura N Broyles
INTRODUCTION: HIV-infected pregnant and breastfeeding adolescents are a particularly vulnerable group that require special attention and enhanced support to achieve optimal maternal and infant outcomes. The objective of this paper is to review published evidence about antenatal care (ANC) service delivery and outcomes for HIV-infected pregnant adolescents in low-income country settings, identify gaps in knowledge and programme services and highlight the way forward to improve clinical outcomes of this vulnerable group...
August 4, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28770641/evidence-on-the-cost-effectiveness-of-lifelong-antiretroviral-therapy-for-prevention-of-mother-to-child-transmission-of-hiv-implications-for-resource-limited-countries-in-sub-saharan-africa
#6
Peslie G Ngambi, Aubrey C Kalungia, Michael R Law, Francis Kalemeera, IIse Truter, Brian Godman, Derick Munkombwe
The 2016 World Health Organization (WHO) consolidated guideline recommends lifelong antiretroviral therapy (ART) for all HIV-infected pregnant and breastfeeding women for preventing mother-to-child HIV transmission (PMTCT). Ambiguity remains about the cost-effectiveness of this strategy in resource-limited developing countries. Areas Covered: We reviewed model-based studies on the cost-effectiveness of lifelong ART (formerly Option B+) relative to previous WHO guidelines for PMTCT. Our search using PubMed, Medline and Google Scholar for articles on Option B+ resulted in the final inclusion of seven studies published between 2012 and 2016...
August 3, 2017: Expert Review of Pharmacoeconomics & Outcomes Research
https://www.readbyqxmd.com/read/28760009/hiv-positive-pregnant-women-attending-the-prevention-of-mother-to-child-transmission-of-hiv-aids-pmtct-services-in-ethiopia-economic-productivity-losses-across-urban-rural-settings
#7
Elias Asfaw Zegeye, Josue Mbonigaba, Sylvia Blanche Kaye
HIV/AIDS impacts significantly on pregnant women and on children in Ethiopia. This impact has a multiplier effect on household economies and on productivity losses, and is expected to vary across rural and urban settings. Applying the human capital approach to data collected from 131 respondents, this study estimated productivity losses per HIV-positive pregnant woman-infant pair across urban and rural health facilities in Ethiopia, which in turn were used to estimate the national productivity loss. The study found that the annual productivity loss per woman-infant pair was Ethiopian birr (ETB) 7,433 or United States dollar (US$) 378 and ETB 625 (US$ 32) in urban and rural settings, respectively...
July 31, 2017: Psychology, Health & Medicine
https://www.readbyqxmd.com/read/28747213/cesarean-delivery-technique-among-hiv-positive-women-with-sub-optimal-antenatal-care-uptake-at-the-douala-general-hospital-cameroon-case-series-report
#8
Thomas Obinchemti Egbe, Charlotte Nguefack Tchente, George-Fulbert Mangala Nkwele, Jacques Ernest Nyemb, Esther Mathio Barla, Eugene Belley-Priso
BACKGROUND: The human immunodeficiency virus (HIV) pandemic is a serious public health problem worldwide, especially in low-income countries of sub-Saharan Africa (SSA). The prevention of mother to child transmission of HIV (PMTCT) is a major concern to those countries. Cesarean section has been described in the literature to be effective in the prevention of mother to child transmission (MTCT). CASE SERIES PRESENTATION: We present a series of seven cases of HIV positive pregnant women with sub-optimal antenatal care up-take who delivered by cesarean section at the Department of Obstetrics and Gynecology of the Douala General Hospital...
July 26, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28747196/-if-donors-woke-up-tomorrow-and-said-we-can-t-fund-you-what-would-we-do-a-health-system-dynamics-analysis-of-implementation-of-pmtct-option-b-in-uganda
#9
Tanya Doherty, Donnela Besada, Ameena Goga, Emmanuelle Daviaud, Sarah Rohde, Nika Raphaely
BACKGROUND: In October 2012 Uganda extended its prevention of mother to child HIV transmission (PMTCT) policy to Option B+, providing lifelong antiretroviral treatment for HIV positive pregnant and breastfeeding women. The rapid changes and adoptions of new PMTCT policies have not been accompanied by health systems research to explore health system preparedness to implement such programmes. The implementation of Option B+ provides many lessons which can inform the shift to 'Universal Test and Treat', a policy which many sub-Saharan African countries are preparing to adopt, despite fragile health systems...
July 26, 2017: Globalization and Health
https://www.readbyqxmd.com/read/28746086/hiv-drug-resistance-in-infants-increases-with-changing-prevention-of-mother-to-child-transmission-regimens
#10
Lisa K Poppe, Catherine Chunda-Liyoka, Eun H Kwon, Clement Gondwe, John T West, Chipepo Kankasa, Clement B Ndongmo, Charles Wood
OBJECTIVES: The objectives of this study were to determine HIV drug resistance (HIVDR) prevalence in Zambian infants upon diagnosis, and to determine how changing prevention of mother-to-child transmission (PMTCT) drug regimens affect drug resistance. DESIGN: Dried blood spot (DBS) samples from infants in the Lusaka District of Zambia, obtained during routine diagnostic screening, were collected during four different years representing three different PMTCT drug treatment regimens...
August 24, 2017: AIDS
https://www.readbyqxmd.com/read/28743251/acceptability-of-lifelong-treatment-among-hiv-positive-pregnant-and-breastfeeding-women-option-b-in-selected-health-facilities-in-zimbabwe-a-qualitative-study
#11
Addmore Chadambuka, Leila Katirayi, Auxilia Muchedzi, Esther Tumbare, Reuben Musarandega, Agnes I Mahomva, Godfrey Woelk
BACKGROUND: Zimbabwe's Ministry of Health and Child Care (MOHCC) adopted 2013 World Health Organization (WHO) prevention of mother-to-child HIV transmission (PMTCT) guidelines recommending initiation of HIV-positive pregnant and breastfeeding women (PPBW) on lifelong antiretroviral treatment (ART) irrespective of clinical stage (Option B+). Option B+ was officially launched in Zimbabwe in November 2013; however the acceptability of life-long ART and its potential uptake among women was not known...
July 25, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28738455/-cost-effectiveness-and-affordability-of-strategy-for-preventing-mother-to-child-transmission-of-hepatitis-b-in-china
#12
Y Lin, S X Zhang, P C Yang, Y L Cai, Y H Zou
Objective: To evaluate the cost effectiveness of nationwide prevention of mother to child transmission (PMTCT) strategy for hepatitis B, and estimate the willing to pay and budget impacts on the PMTCT. Methods: The decision analytic Markov model for the PMTCT was constructed and a birth cohort of Chinese infants born in 2013 was used to calculate the cost-effectiveness of the PMTCT among them compared with those receiving no intervention. The parameters in the model were obtained from literatures of national surveys or Meta-analysis...
July 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28714809/reticence-in-disclosure-of-hiv-infection-and-reasons-for-bereavement-impact-on-perinatally-infected-adolescents-mental-health-and-understanding-of-hiv-treatment-and-prevention-in-johannesburg-south-africa
#13
Nataly Woollett, Vivian Black, Lucie Cluver, Heena Brahmbhatt
Survival rates of perinatally infected HIV-positive adolescents (PIA) are increasing in sub-Saharan Africa. There is a gap in understanding how disclosure and bereavement have an impact on PIA beliefs and understanding of their HIV infection and its management. In-depth interviews were conducted with 25 purposively selected adolescents aged 13-19 years from 5 public health clinics in Johannesburg, South Africa. Data were analysed using NVivo 10 using a thematic approach. PIA experience incomplete disclosure both of their HIV status and reasons for their bereavements, which limits their understanding of how they became infected, vertical transmission and prevention options like prevention of mother-to-child transmission (PMTCT)...
July 17, 2017: African Journal of AIDS Research: AJAR
https://www.readbyqxmd.com/read/28707345/the-cascade-of-care-to-prevent-mother-to-child-transmission-in-rio-de-janeiro-brazil-1996-2013-improving-but-still-some-way-to-go
#14
Cristina Barroso Hofer, Matthias Egger, Mary-Ann Davies, Ana Cristina Cisne Frota, Ricardo Hugo de Oliveira, Thalita Fernandes Abreu, Lúcia Evangelista Araújo, Bernardo Bastos Witthlin, Alice Weber Carvalho, Janaína Rivas Cordeiro, Giulia Pasqualini Lima, Olivia Keiser
OBJECTIVE: To describe the cascade of care to HIV mother-to-child-transmission (PMTCT) in a Rio de Janeiro reference pediatric clinic, and evaluate the main factors possibly associated with HIV transmission. METHODS: Data on antenatal care, perinatal and neonatal assistance to HIV-infected and HIV-exposed but uninfected children assisted in the clinic from 1996-2013 were collected. The cascade of care was graphically demonstrated, and possible factors associated with HIV infection were described using regression models for bivariate and multivariate analysis...
July 14, 2017: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/28705148/correlates-of-facility-delivery-for-rural-hiv-positive-pregnant-women-enrolled-in-the-moment-nigeria-prospective-cohort-study
#15
Nadia A Sam-Agudu, Christopher Isah, Chinenye Fan-Osuala, Salome Erekaha, Habib O Ramadhani, Udochisom Anaba, Olusegun A Adeyemi, Grace Manji-Obadiah, Daniel Lee, Llewellyn J Cornelius, Manhattan Charurat
BACKGROUND: Low rates of maternal healthcare service utilization, including facility delivery, may impede progress in the prevention of mother-to-child transmission of HIV (PMTCT) and in reducing maternal and infant mortality. The MoMent (Mother Mentor) study investigated the impact of structured peer support on early infant diagnosis presentation and postpartum maternal retention in PMTCT care in rural Nigeria. This paper describes baseline characteristics and correlates of facility delivery among MoMent study participants...
July 14, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28704472/prevention-of-mother-to-child-transmission-of-hiv-option-b-cascade-in-rural-tanzania-the-one-stop-clinic-model
#16
Anna Gamell, Lameck Bonaventure Luwanda, Aneth Vedastus Kalinjuma, Leila Samson, Alex John Ntamatungiro, Maja Weisser, Winfrid Gingo, Marcel Tanner, Christoph Hatz, Emilio Letang, Manuel Battegay
BACKGROUND: Strategies to improve the uptake of Prevention of Mother-To-Child Transmission of HIV (PMTCT) are needed. We integrated HIV and maternal, newborn and child health services in a One Stop Clinic to improve the PMTCT cascade in a rural Tanzanian setting. METHODS: The One Stop Clinic of Ifakara offers integral care to HIV-infected pregnant women and their families at one single place and time. All pregnant women and HIV-exposed infants attended during the first year of Option B+ implementation (04/2014-03/2015) were included...
2017: PloS One
https://www.readbyqxmd.com/read/28696347/building-health-system-capacity-through-implementation-research-experience-of-inspire-a-multi-country-pmtct-implementation-research-project-erratum
#17
(no author information available yet)
No abstract text is available yet for this article.
August 15, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28693525/baseline-characteristics-of-study-sites-and-women-enrolled-in-a-three-arm-cluster-randomized-controlled-trial-pmtct-uptake-and-retention-pure-malawi
#18
Monique van Lettow, Hannock Tweya, Nora E Rosenberg, Clement Trapence, Virginia Kayoyo, Florence Kasende, Blessings Kaunda, Mina C Hosseinipour, Michael Eliya, Fabian Cataldo, Salem Gugsa, Sam Phiri
BACKGROUND: Malawi introduced an ambitious public health program known as "Option B+" which provides all HIV-infected pregnant and breastfeeding women with lifelong combination antiretroviral therapy, regardless of WHO clinical stage or CD4 cell count. The PMTCT Uptake and REtention (PURE) study aimed at evaluating the effect of peer-support on care-seeking and retention in care. METHODS/DESIGN: PURE Malawi was a three-arm cluster randomized controlled trial that compared facility-based and community-based models of peer support to standard of care under Option B+ strategy...
July 11, 2017: Reproductive Health
https://www.readbyqxmd.com/read/28683718/rate-of-hiv-transmission-and-associated-factors-among-hiv-exposed-infants-in-selected-health-facilities-of-east-and-west-gojjam-zones-northwest-ethiopia-retrospective-cohort-study
#19
Nurilign Abebe Moges, Getachew Mullu Kassa, Dube Jara Boneya
BACKGROUND: In 2014, there were 170,000 new HIV-infected children globally. The rate of HIV transmission from mother to child in Ethiopia was 18%. Though there are a number of HIV-related studies conducted in Ethiopia, there is a scarcity of evidence on the rate of mother to child transmission. So, the aim of this study was to determine the rate of HIV transmission and associated factors among HIV-exposed infants in selected health facilities in East and West Gojjam Zones, Northwest Ethiopia...
July 6, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28679418/transitioning-from-antenatal-surveillance-surveys-to-routine-hiv-testing-a-turning-point-in-the-mother-to-child-transmission-prevention-programme-for-hiv-surveillance-in-brazil
#20
Gerson Fernando Mendes Pereira, Meritxell Sabidó, Alessandro Caruso, Adele Schwartz Benzaken
BACKGROUND: In Brazil, due to the rapid increase in programmes for the prevention of mother-to-child transmission (PMTCT), routine programme data are widely available. The objective of this study was to assess the utility of programmatic data to replace HIV surveillance based on the antenatal care (ANC) surveillance survey (SS). METHODS: We analysed ANC SS data from 219 maternity service clinics. PMTCT variables were extracted from the ANC SS data collection form, which allowed us to capture and compare the ANC SS data and PMTCT HIV test results for each pregnant woman who completed the ANC SS...
July 5, 2017: BMC Infectious Diseases
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