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https://www.readbyqxmd.com/read/29164754/interventions-to-significantly-improve-service-uptake-and-retention-of-hiv-positive-pregnant-women-and-hiv-exposed-infants-along-the-pmtct-continuum-of-care-systematic-review
#1
REVIEW
Alexandra C Vrazo, Jacqueline Firth, Anouk Amzel, Rebecca Sedillo, Julia Ryan, B Ryan Phelps
OBJECTIVES: Despite the success of Prevention of Mother-to-Child Transmission of HIV (PMTCT) programs, low uptake of services and poor retention pose a formidable challenge to achieving the elimination of vertical HIV transmission in low and middle-income countries. This systematic review summarizes interventions that demonstrate statistically significant improvements in service uptake and retention of HIV-positive pregnant and breastfeeding women and their infants along the PMTCT cascade...
November 22, 2017: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/29158723/the-usefulness-of-traditional-birth-attendants-to-women-living-with-hiv-in-resource-poor-settings-the-case-of-mfuwe-zambia
#2
Choolwe Muzyamba, Wim Groot, Sonila M Tomini, Milena Pavlova
Background: Although there is increased attention on the role of trained traditional birth attendants (TBAs) in maternal care, most of the research has mainly focused on providing evidence of the relevance of trained TBAs to women in general without a specific focus on women who are HIV positive, despite them being most vulnerable. Therefore, the aim of this study is to fill this gap by assessing the relevance of trained TBAs to women living with HIV in resource-poor settings by using Zambia as a case study...
2017: Tropical Medicine and Health
https://www.readbyqxmd.com/read/29130333/non-disclosure-to-male-partners-and-incomplete-pmtct-regimens-associated-with-higher-risk-of-mother-to-child-hiv-transmission-a-national-survey-in-kenya
#3
Christine J McGrath, Benson Singa, Agnes Langat, John Kinuthia, Keshet Ronen, Danvers Omolo, Benjamin Elly Odongo, Rose Wafula, Prisca Muange, Abraham Katana, Lucy Ng'anga', Grace C John-Stewart
Health worker experience and community support may be higher in high HIV prevalence regions than low prevalence regions, leading to improved prevention of mother-to-child HIV transmission (PMTCT) programs. We evaluated 6-week and 9-month infant HIV transmission risk (TR) in a high prevalence region and nationally. Population-proportionate-to-size sampling was used to select 141 clinics in Kenya, and mobile teams surveyed mother-infant pairs attending 6-week and 9-month immunizations. HIV DNA testing was performed on HIV-exposed infants...
November 11, 2017: AIDS Care
https://www.readbyqxmd.com/read/29104275/factors-associated-with-male-partner-involvement-in-programs-for-the-prevention-of-mother-to-child-transmission-of-hiv-in-rural-south-africa
#4
Motlagabo G Matseke, Robert A C Ruiter, Violeta J Rodriguez, Karl Peltzer, Geoffrey Setswe, Sibusiso Sifunda
Male partner involvement (MPI) can contribute to the success of programs aimed at preventing mother-to-child transmission (PMTCT) of HIV. However, the definition and measures of MPI differ according to context. This study utilized secondary cross-sectional data to investigate the prevalence and determinants of MPI among 463 male partners of HIV-infected pregnant women in rural South Africa. Results indicated that 44.1% of male partners reported involvement in most or all specified male partner involvement activities (i...
November 1, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29102993/evidence-of-accessibility-and-utility-of-point-of-care-diagnostics-as-an-integral-part-of-prevention-of-mother-to-child-transmission-services-systematic-scoping-review-protocol
#5
Juliet Katoba, Lydia Hangulu, Tivani Phosa Mashamba-Thompson
INTRODUCTION: Point-of-care (POC) testing has been shown to help improve healthcare access in resource-limited settings. However, there is paucity of evidence on accessibility of POC testing for prevention of mother-to-child transmission (PMTCT) in resource-limited settings. We propose to conduct a systematic scoping review to map the evidence on POC testing services for PMTCT. METHODS AND ANALYSIS: A scoping review framework, proposed by Arksey and O'Malley, will guide the study...
November 4, 2017: BMJ Open
https://www.readbyqxmd.com/read/29084045/declining-baseline-viraemia-and-escalating-discordant-hiv-1-confirmatory-results-within-south-africa-s-early-infant-diagnosis-program-2010-2016
#6
Ahmad Haeri Mazanderani, Faith Moyo, Tendesayi Kufa, Gayle G Sherman
OBJECTIVE: To describe baseline HIV-1 RNA viral load (VL) trends within South Africa's Early Infant Diagnosis (EID) program 2010-2016, with reference to prevention of mother-to-child transmission (PMTCT) guidelines. METHODS: HIV-1 total nucleic acid polymerase chain reaction (TNA PCR) and RNA VL data from 2010-2016 were extracted from the South African National Health Laboratory Service's central data repository. Infants with a positive TNA PCR and subsequent baseline RNA VL taken at age <7 months were included...
October 27, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29073829/hiv-testing-among-male-partners-of-pregnant-women-in-nigeria-a-missing-link-in-the-elimination-of-mother-to-child-transmission-of-hiv
#7
Babayemi O Olakunde, Daniel A Adeyinka, Tolulope Oladele, Chamberline E Ozigbu
In this study, we assessed male partner testing and the serodiscordance rate among pregnant women and their partners in the prevention of mother-to-child transmission (PMTCT) programme in Nigeria. We conducted a retrospective analysis of the consolidated national health sector PMTCT data over a five-year period (2012-2016). Over the period, a total of 11,833,062 pregnant women were tested for HIV with a positivity rate of 2.2%. About 266,188 (2.2%) of sexual partners of pregnant women who presented at PMTCT clinics had an HIV test within the period...
January 1, 2017: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/29069378/the-effect-of-a-performance-based-financing-program-on-hiv-and-maternal-child-health-services-in-mozambique-an-impact-evaluation
#8
Yogesh Rajkotia, Omer Zang, Pierre Nguimkeu, Jessica Gergen, Iva Djurovic, Paula Vaz, Franscisco Mbofana, Kebba Jobarteh
Performance-based financing (PBF) is a mechanism by which health providers are paid on the basis of outputs or results delivered. A PBF program was implemented on the provision of HIV, prevention of mother-to child HIV transmission (PMTCT), and maternal/child health (MCH) services in two provinces of Mozambique. A retrospective case-control study design was used in which PBF provinces were matched with control provinces to evaluate the impact of PBF on 18 indicators. Due to regional heterogeneity, we evaluated the intervention sites (North and South) separately...
December 1, 2017: Health Policy and Planning
https://www.readbyqxmd.com/read/29062860/in-utero-art-exposure-and-birth-and-early-growth-outcomes-among-hiv-exposed-uninfected-infants-attending-immunization-services-results-from-national-pmtct-surveillance-south-africa
#9
Vundli Ramokolo, Ameena E Goga, Carl Lombard, Tanya Doherty, Debra J Jackson, Ingunn Ms Engebretsen
BACKGROUND: Despite the recognized benefit of antiretroviral therapy (ART) for preventing and treating HIV, some studies have reported adverse birth outcomes with in utero ART exposure. We evaluated the effect of infant in utero HIV and ART exposure on preterm delivery (PTD), low birth weight (LBW), small for gestational age (SGA), and underweight for age (UFA) at 6 weeks. METHODS: We surveyed 6179 HIV-unexposed-uninfected (HUU) and 2599 HIV-exposed-uninfected (HEU) infants...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/29034724/prevention-of-mother-to-child-transmission-of-hiv-in-yaounde-barrier-to-care
#10
C C Landefeld, L A Fomenou, F Ateba, P Msellati
Most HIV-infected children in Sub-Saharan Africa are born where programs for the prevention of mother-to-child transmission of HIV (PMTCT) exist but are not universally operational. The expansion of PMTCT programs in Cameroon was among the largest in francophone Africa, but despite highly variable estimates of PMTCT uptake (ranging from 20% to 66%), it is clear that not enough HIV-infected pregnant Cameroonian women benefit from treatment to prevent HIV transmission to their children. The reasons why HIV-infected women in Cameroon do not use treatments to prevent this transmission remain partially unidentified...
October 16, 2017: AIDS Care
https://www.readbyqxmd.com/read/29029086/hiv-prevention-costs-and-their-predictors-evidence-from-the-orphea-project-in-kenya
#11
Omar Galárraga, Richard G Wamai, Sandra G Sosa-Rubí, Mercy G Mugo, David Contreras-Loya, Sergio Bautista-Arredondo, Helen Nyakundi, Joseph K Wang'ombe
We estimate costs and their predictors for three HIV prevention interventions in Kenya: HIV testing and counselling (HTC), prevention of mother-to-child transmission (PMTCT) and voluntary medical male circumcision (VMMC). As part of the 'Optimizing the Response of Prevention: HIV Efficiency in Africa' (ORPHEA) project, we collected retrospective data from government and non-governmental health facilities for 2011-12. We used multi-stage sampling to determine a sample of health facilities by type, ownership, size and interventions offered totalling 144 sites in 78 health facilities in 33 districts across Kenya...
December 1, 2017: Health Policy and Planning
https://www.readbyqxmd.com/read/29022530/male-involvement-in-prevention-of-mother-to-child-transmission-of-hiv-in-the-context-of-partner-testing-in-goba-town-ethiopia-a-facility-based-cross-sectional-study
#12
M T Alemayehu, J Haidar
BACKGROUND: Antenatal care (ANC) is an entry point for the prevention of mother-to-child transmission (PMTCT), particularly when a man accompanies his spouse for voluntary counselling and testing (VCT), even though this seldom happens in Ethiopia. OBJECTIVE: To study the role of male partners in improving PMTCT/ANC, which is essential to prevent HIV/AIDS transmission in this country. Our study focused on identifying barriers for the low involvement in PMTCT/ANC among male partners whose spouses received ANC...
September 22, 2017: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/29020335/hiv-drug-resistance-in-african-infants-and-young-children-newly-diagnosed-with-hiv-a-multicounty-analysis
#13
Michael R Jordan, Martina Penazzato, Amandine Cournil, Adolfo Vubil, Ilesh Jani, Gillian Hunt, Sergio Carmona, Gugu Maphalala, Nobuhle Mthethwa, Christine Watera, Pontiano Kaleebu, Christine Chakanyuka Musanhu, Sekesai Mtapuri-Zinyowera, Janet Dzangare, Martine Peeters, Chunfu Yang, Neil Parkin, Silvia Bertagnolio
Background: Prevention of mother-to-child transmission (PMTCT) of HIV programs have been scaled-up in many low- and middle-income countries; however, HIV drug resistance (HIVDR) data amongst HIV-1-infected young children remain limited. Methods: Surveys of pre-treatment HIVDR amongst children younger than 18 months of age who were diagnosed with HIV through Early Infant Diagnosis were conducted in five sub-Saharan African countries (Mozambique, Swaziland, South Africa, Uganda, and Zimbabwe) between 2011 and 2014 following World Health Organization guidance...
August 8, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28986949/the-relationship-between-hiv-and-fertility-in-the-era-of-antiretroviral-therapy-in-sub-saharan-africa-evidence-from-49-demographic-and-health-surveys
#14
M Marston, B Zaba, J W Eaton
OBJECTIVES: To describe regional differences in the relative fertility of HIV-positive vs. HIV-negative women and changes as antiretroviral treatment (ART) is scaled up, to improve estimates of predicted need for and coverage of prevention of mother-to-child transmission services at national and subnational levels. METHODS: We analysed 49 nationally representative household surveys in sub-Saharan Africa between 2003 and 2016 to estimate fertility rate ratios of HIV-positive and HIV-negative women by age using exponential regression and test for regional and urban/rural differences...
October 6, 2017: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/28984760/implementation-effectiveness-of-revised-post-2010-world-health-organization-guidelines-on-prevention-of-mother-to-child-transmission-of-hiv-using-routinely-collected-data-in-sub-saharan-africa-a-systematic-literature-review
#15
REVIEW
Sehlulekile Gumede-Moyo, Suzanne Filteau, Tendai Munthali, Jim Todd, Patrick Musonda
BACKGROUND: To synthesize and evaluate the impact of implementing post-2010 World Health Organization (WHO) prevention of mother-to-child transmission (PMTCT) guidelines on attainment of PMTCT targets. METHODS: Retrospective and prospective cohort study designs that utilized routinely collected data with a focus on provision and utilization of the cascade of PMTCT services were included. The outcomes included the proportion of pregnant women who were tested during their antenatal clinic (ANC) visits; mother-to-child transmission (MTCT) rate; adherence; retention rate; and loss to follow-up (LTFU)...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28971710/women-s-decision-making-and-uptake-of-services-to-prevent-mother-to-child-hiv-transmission-in-zambia
#16
Catherine Ford, Carla J Chibwesha, Jennifer Winston, Choolwe Jacobs, Mwansa Ketty Lubeya, Patrick Musonda, Jeffrey S A Stringer, Benjamin H Chi
Women's empowerment is associated with engagement in some areas of healthcare, but its role in prevention of mother-to-child HIV transmission (PMTCT) services has not been previously considered. In this secondary analysis, we investigated the association of women's decision-making and uptake of health services for PMTCT. Using data from population-based household surveys, we included women who reported delivery in the 2-year period prior to the survey and were HIV-infected. We measured a woman's self-reported role in decision-making in her own healthcare, making of large purchases, schooling of children, and healthcare for children...
October 3, 2017: AIDS Care
https://www.readbyqxmd.com/read/28961680/high-prevalence-of-hiv-drug-resistance-among-newly-diagnosed-infants-aged-18-months-results-from-a-nationwide-surveillance-in-nigeria
#17
Seth Chekata Inzaule, Samuels Jay Osi, Gbenga Akinbiyi, Asadu Emeka, Hadiza Khamofu, Rex Mpazanje, Oluwafunke Ilesanmi, Nicaise Ndembi, Solomon Odafe, Kim C E Sigaloff, Tobias F Rinke de Wit, Sulaimon Akanmu
BACKGROUND: The world-health organization recommends protease-inhibitor-based first-line regimen in infants due to risk of drug resistance from failed prophylaxis used in prevention-of-mother-to-child transmission (PMTCT). However cost and logistics impede implementation in sub-Saharan Africa and >75% of children still receive non-nucleoside reverse transcriptase inhibitor-based regimen (NNRTI) used in PMTCT. METHODS: We assessed the national pre-treatment drug resistance prevalence of HIV-infected children <18 months in Nigeria, using the WHO recommended HIV drug resistance surveillance protocol...
September 25, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28946847/changing-times-gender-roles-and-relationships-in-maternal-newborn-and-child-health-in-malawi
#18
Lucinda Manda-Taylor, Daniel Mwale, Tamara Phiri, Aisling Walsh, Anne Matthews, Ruairi Brugha, Victor Mwapasa, Elaine Byrne
BACKGROUND: For years, Malawi remained at the bottom of league tables on maternal, neonatal and child health. Although maternal mortality ratios have reduced and significant progress has been made in reducing neonatal morality, many challenges in achieving universal access to maternal, newborn and child health care still exist in Malawi. In Malawi, there is still minimal, though increasing, male involvement in ANC/PMTCT/MNCH services, but little understanding of why this is the case. The aim of this paper is to explore the role and involvement of men in MNCH services, as part of the broader understanding of those community system factors...
September 25, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28923018/effects-on-preventing-mother-to-child-transmission-of-syphilis-and-associated-adverse-pregnant-outcomes-a-longitudinal-study-from-2001-to-2015-in-shanghai-china
#19
Yang Li, Liping Zhu, Li Du, Lingxiao Qu, Weili Jiang, Biao Xu
BACKGROUND: Maternal syphilis is a health threat to both the pregnant women and the children. This study aimed to delineate the longitudinal trend of maternal syphilis and burden of associated adverse pregnant outcomes (APOs) in Shanghai from 2001 to 2015; and to evaluate the effects of preventing mother-to-child transmission (PMTCT) of syphilis in Shanghai with regard to service coverage and APOs averted. METHODS: PMTCT program of syphilis has been implemented since 2001...
September 18, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28922974/the-achilles-heel-of-prevention-to-mother-to-child-transmission-of-hiv-protocol-implementation-uptake-and-sustainability
#20
Violeta J Rodriguez, Richard P LaCabe, C Kyle Privette, K Marie Douglass, Karl Peltzer, Gladys Matseke, Audrey Mathebula, Shandir Ramlagan, Sibusiso Sifunda, Guillermo Willy Prado, Viviana Horigian, Stephen M Weiss, Deborah L Jones
The Joint United Nations Programme on HIV and AIDS proposed to reduce the vertical transmission of HIV from ∼72,200 to ∼8300 newly infected children by 2015 in South Africa (SA). However, cultural, infrastructural, and socio-economic barriers hinder the implementation of the prevention of mother-to-child transmission (PMTCT) protocol, and research on potential solutions to address these barriers in rural areas is particularly limited. This study sought to identify challenges and solutions to the implementation, uptake, and sustainability of the PMTCT protocol in rural SA...
December 2017: SAHARA J: Journal of Social Aspects of HIV/AIDS Research Alliance
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