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https://www.readbyqxmd.com/read/28498195/building-health-system-capacity-through-implementation-research-experience-of-inspire-a-multi-country-pmtct-implementation-research-project
#1
Morkor Newman Owiredu, Nita B Bellare, Christine C Chakanyuka Musanhu, Taiwo A Oyelade, Ellen M Thom, Francoise Bigirimana, Chukwuma Anyaike, Michael T Eliya, Angela Mushavi, Eugene A Nyarko, David O Okello, Felicitas R Zawaira
BACKGROUND: The INSPIRE-Integrating and Scaling Up PMTCT through Implementation REsearch-initiative was established as a model partnership of national prevention of mother-to-child transmission of HIV (PMTCT) implementation research in 3 high HIV burden countries-Malawi, Nigeria, and Zimbabwe. INSPIRE aimed to link local research groups with Ministries of Health (MOH), build local research capacity, and demonstrate that implementation research may contribute to improving health care delivery and respond to program challenges...
June 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28498193/the-roles-of-expert-mothers-engaged-in-prevention-of-mother-to-child-transmission-pmtct-programs-a-commentary-on-the-inspire-studies-in-malawi-nigeria-and-zimbabwe
#2
Fabian Cataldo, Nadia A Sam-Agudu, Sam Phiri, Bridget Shumba, Llewellyn J Cornelius, Geoff Foster
INTRODUCTION: Several initiatives aiming to improve retention and adherence in Prevention of Mother-to-Child Transmission of HIV (PMTCT) programs include "expert mothers" (EMs) as a central tenet of their interventions. This article compares the role of EMs in 3 implementation research studies examining approaches for improving retention in care among mothers living with HIV. METHODS: We compared and synthesized qualitative data and lessons learned from 3 studies (MoMent in Nigeria, PURE in Malawi, and EPAZ in Zimbabwe) with respect to the involvement of EMs in supporting PMTCT clients...
June 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28498191/impact-of-facility-based-mother-support-groups-on-retention-in-care-and-pmtct-outcomes-in-rural-zimbabwe-the-epaz-cluster-randomized-controlled-trial
#3
Geoff Foster, Joanna Orne-Gliemann, Hélène Font, Abigail Kangwende, Vhumani Magezi, Tonderai Sengai, Simba Rusakaniko, Bridget Shumba, Pemberai Zambezi, Talent Maphosa
BACKGROUND: Prevention of mother-to-child transmission elimination goals are hampered by low rates of retention in care. The Eliminating Paediatric AIDS in Zimbabwe project assessed whether mother support groups (MSGs) improve rates of retention in care of HIV-exposed infants and their HIV-positive mothers, and maternal and infant outcomes. METHODS: The study involved 27 rural clinics in eastern Zimbabwe. MSGs were established in 14 randomly selected clinics and met every 2 weeks coordinated by volunteer HIV-positive mothers...
June 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28498187/the-impact-of-structured-mentor-mother-programs-on-6-month-postpartum-retention-and-viral-suppression-among-hiv-positive-women-in-rural-nigeria-a-prospective-paired-cohort-study
#4
Nadia A Sam-Agudu, Habib O Ramadhani, Christopher Isah, Udochisom Anaba, Salome Erekaha, Chinenye Fan-Osuala, Hadiza Galadanci, Manhattan Charurat
BACKGROUND: Peer support (PS) has reportedly improved Prevention of mother-to-child transmission (PMTCT) outcomes in high HIV-burden settings; however, evidence of impact on retention in care is limited. Retention in care implies consistent engagement and treatment adherence. The MoMent study evaluated the impact of structured vs unstructured PS on postpartum retention and viral load suppression among rural Nigerian women. METHODS: A total of 497 HIV-positive pregnant women were consecutively enrolled at 10 primary health care centers with structured mentor mother (MM) support, and at 10 pair-matched primary health care centers with routine, ad hoc PS...
June 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28498186/using-small-tests-of-change-to-improve-pmtct-services-in-northern-nigeria-experiences-from-implementation-of-a-continuous-quality-improvement-and-breakthrough-series-program
#5
Bamidele Osibo, Frank Oronsaye, Oluwafemi D Alo, Abimbola Phillips, Renaud Becquet, Nathan Shaffer, Francis Ogirima, Collins Imarhiagbe, Bernice Ameh, Obioma Ezebuka, Sodzi Sodzi-Tettey, Adaobi Obi, Olusegun T Afolabi, Abutu Inedu, Chukwuma Anyaike, Bolanle Oyeledun
BACKGROUND: Continuous Quality Improvement (CQI) is a process where health teams systematically collect and regularly reflect on local data to inform decisions and modify local practices and so improve delivery of services. We implemented a cluster randomized trial to examine the effects of CQI interventions on Prevention of Mother-to-Child Transmission (PMTCT) services. Here, we report our experiences and challenges establishing CQI in 2 high HIV prevalence states in northern Nigeria...
June 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28498185/the-effect-of-a-continuous-quality-improvement-intervention-on-retention-in-care-at-6-months-postpartum-in-a-pmtct-program-in-northern-nigeria-results-of-a-cluster-randomized-controlled-study
#6
Bolanle Oyeledun, Abimbola Phillips, Frank Oronsaye, Oluwafemi David Alo, Nathan Shaffer, Bamidele Osibo, Collins Imarhiagbe, Francis Ogirima, Abiola Ajibola, Obioma Ezebuka, Bebia Ojong-Etta, Adaobi Obi, John Falade, Adunbi Kareem Uthman, Busuyi Famuyide, Deborah Odoh, Renaud Becquet
BACKGROUND: Retention in care is critical for improving HIV-infected maternal outcomes and reducing vertical transmission. Health systems' interventions such as continuous quality improvement (CQI) may support health services to address factors that affect the delivery of HIV-related care and thereby influence rates of retention-in-care. METHODOLOGY: We evaluated the effect of a CQI intervention on retention-in-care at 6 months postpartum of pregnant women and mothers living with HIV who had been started on lifelong antiretroviral treatment...
June 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28498178/supporting-implementation-research-to-improve-coverage-and-uptake-of-hiv-related-interventions
#7
Pierre Blais, Sylvia Sirivar, Joyce Seto
In 2015, Global Affairs Canada joined other members of the United Nations to establish the Sustainable Development Goals, which include the elimination of AIDS by 2030. Innovation is an important part of accelerating the response against HIV and ensuring success in eliminating AIDS by 2030. This is the reason Global Affairs Canada decided to partner with the World Health Organization, to support the INtegration and Scaling Up PMTCT through Implementation REsearch (INSPIRE) initiative, to learn how HIV interventions can be successfully integrated with other essential health services for mothers and children, especially among the most vulnerable populations...
June 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28482821/understanding-coping-strategies-during-pregnancy-and-the-postpartum-period-a-qualitative-study-of-women-living-with-hiv-in-rural-uganda
#8
Scholastic Ashaba, Angela Kaida, Bridget Frances Burns, Kasey O'Neil, Emma Dunkley, Christina Psaros, Jasmine Kastner, Alexander C Tsai, David R Bangsberg, Lynn T Matthews
BACKGROUND: In sub-Saharan Africa, 58% of adults living with HIV are women. In Uganda, HIV prevalence is 8.3% for women compared to 6.1% for men. Access to antiretroviral therapy (ART) and prevention of mother to child transmission (PMTCT) programs have enabled women living with HIV (WLWH) to have children with minimal risk of perinatal transmission. Nevertheless, pregnant WLWH face many challenges. We explored women's perceptions of how they cope with the challenges of pregnancy and the postpartum period as HIV-infected women...
May 8, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28470110/growth-pattern-in-ethiopian-infants-the-impact-of-exposure-to-maternal-hiv-infection-in-relation-to-socio-economic-factors
#9
John König Walles, Taye Tolera Balcha, Niclas Winqvist, Per Björkman
BACKGROUND: Infants exposed to maternal HIV infection who remain HIV-uninfected (HIV-exposed/uninfected; HIV-EU) may be at increased risk of growth retardation, which could be due both to directly HIV-related effects and to socio-economic factors overrepresented among HIV-positive women. OBJECTIVE: To investigate growth development at 9-12 months of age in HIV-EU infants participating in prevention of mother-to-child transmission (PMTCT) care compared to HIV unexposed (HIV-U) infants in relation to socio-economic conditions...
2017: Global Health Action
https://www.readbyqxmd.com/read/28470071/nurses-knowledge-attitudes-and-practices-regarding-evidence-based-practice-in-the-prevention-of-mother-to-child-transmission-of-hiv-programme-in-malawi
#10
Chisomo Mulenga, Joanne R Naidoo
BACKGROUND: HIV continues to be a global public health concern with Malawi being among the worst affected countries. The prevalence of HIV among pregnant women is also very high, thereby raising concerns of mother-to-child transmission of the virus. Prevention of mother-to-child transmission (PMTCT) of HIV is therefore a priority in the efforts to curb the HIV pandemic. Keeping in mind that the area of HIV management is rapidly evolving, underpinning nursing care with evidence-based practice is essential and has been reported to reduce mother-to-child transmission...
April 12, 2017: Curationis
https://www.readbyqxmd.com/read/28453240/virological-response-and-resistances-over-12-months-among-hiv-infected-children-less-than-two-years-receiving-first-line-lopinavir-ritonavir-based-antiretroviral-therapy-in-cote-d-ivoire-and-burkina-faso-the-monod-anrs-12206-cohort
#11
Clarisse Amani-Bosse, Désiré Lucien Dahourou, Karen Malateste, Madeleine Amorissani-Folquet, Malik Coulibaly, Sophie Dattez, Arlette Emieme, Mamadou Barry, Christine Rouzioux, Sylvie N'gbeche, Caroline Yonaba, Marguerite Timité-Konan, Véronique Mea, Sylvie Ouédraogo, Stéphane Blanche, Nicolas Meda, Carole Seguin-Devaux, Valériane Leroy
INTRODUCTION: Lopinavir/ritonavir-based antiretroviral therapy (ART) is recommended for all HIV-infected children less than three years. However, little is known about its field implementation and effectiveness in West Africa. We assessed the 12-month response to lopinavir/ritonavir-based antiretroviral therapy in a cohort of West African children treated before the age of two years. METHODS: HIV-1-infected, ART-naive except for a prevention of mother-to-child transmission (PMTCT), tuberculosis-free, and less than two years of age children with parent's consent were enrolled in a 12-month prospective therapeutic cohort with lopinavir/ritonavir ART and cotrimoxazole prophylaxis in Ouagadougou and Abidjan...
April 25, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28449111/migrant-women-living-with-hiv-in-europe-are-they-facing-inequalities-in-the-prevention-of-mother-to-child-transmission-of-hiv-the-european-pregnancy-and-paediatric-hiv-cohort-collaboration-eppicc-study-group-in-eurocoord
#12
G Favarato, H Bailey, F Burns, L Prieto, A Soriano-Arandes, C Thorne
In pregnancy early interventions are recommended for prevention of mother-to-child-transmission (PMTCT) of HIV. We examined whether pregnant women who live with HIV in Europe and are migrants encounter barriers in accessing HIV testing and care. Four cohorts within the European Pregnancy and Paediatric HIV Cohort Collaboration provided data for pooled analysis of 11 795 pregnant women who delivered in 2002-12 across ten European countries. We defined a migrant as a woman delivering in a country different from her country of birth and grouped the countries into seven world regions...
April 25, 2017: European Journal of Public Health
https://www.readbyqxmd.com/read/28443275/integration-of-hiv-testing-into-maternal-newborn-and-child-health-weeks-for-improved-case-finding-and-linkage-to-prevention-of-mother-to-child-transmission-services-in-benue-state-nigeria
#13
Olusoji Akinleye, Gideon Dura, Arjan de Wagt, Abiola Davies, Dick Chamla
BACKGROUND: In Nigeria, maternal, newborn, and child health (MNCH) weeks are campaign-like events designed to accelerate progress toward Millennium Development Goals. The authors examined whether integrating HIV testing into MNCH weeks was feasible and could lead to increased case finding and linkage to prevention of mother-to-child transmission (PMTCT) services. METHODS: Pregnant women attending MNCH week during the first week of December 2014 in 13 local government areas in Benue State were provided with HIV tests and referrals to PMTCT services...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/28421355/addressing-early-retention-in-antenatal-care-among-hiv-positive-women-through-a-simple-intervention-in-kinshasa-drc-the-elombe-champion-standard-operating-procedure
#14
Michelle M Gill, John Ditekemena, Aimé Loando, Nana Mbonze, Jo Bakualufu, Rhoderick Machekano, Cady Nyombe, Marleen Temmerman, Franck Fwamba
This cluster-randomized study aimed to assess the Elombe ("Champion") standard operating procedure (SOP), implemented by providers and Mentor Mothers, on HIV-positive pregnant women's retention between first and second antenatal visits. Sixteen facilities in Kinshasa were randomly assigned to intervention (SOP) or comparison (no SOP). Effect of the SOP was estimated using relative risk. Women in comparison facilities were more likely to miss second visits (RR 2.5, 95% CI 1.05-5.98) than women in intervention facilities (30...
April 18, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28420249/increasing-hiv-testing-among-pregnant-women-in-nigeria-evaluating-the-traditional-birth-attendant-and-primary-health-center-integration-tap-in-model
#15
Amara Frances Chizoba, Jennifer R Pharr, Gina Oodo, Edith Ezeobi, Jude Ilozumb, Johnbull Egharevba, Echezona E Ezeanolue, Anthea Nwandu
Engaging Traditional Birth Attendants (TBAs) may be critical to preventing mother-to-child transmission of HIV (PMTCT) in Nigeria. We integrated TBAs into Primary Health Centers (PHCs) and provided the TBAs with HIV counseling and testing (HCT) training for PMTCT (TAP-In). The purpose of this study was to evaluate the impact of TAP-In on HCT uptake among pregnant women. A quasi-experimental design was used for this study. Twenty PHCs were assigned to the intervention group that integrated TAP-In and 20 were assigned to the control group...
April 18, 2017: AIDS Care
https://www.readbyqxmd.com/read/28418986/performance-of-virological-testing-for-early-infant-diagnosis-a-systematic-review
#16
Divya Mallampati, Nathan Ford, Alisse Hanaford, Nandita Sugandhi, Martina Penazzato
BACKGROUND: Improved access to both maternal antiretroviral therapy (ART) and infant prophylaxis may have an impact on the performance of virological assays for diagnosis of HIV infection in infants. This systematic review was performed to assess the diagnostic accuracy of virological testing at birth as well as the performance of virological testing on dried-blood spots at 6-weeks amongst HIV- and ARV-exposed infants. METHODS: A systematic review was performed for studies published between January 1, 2009 and January 30, 2015...
April 7, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28410374/factors-influencing-postnatal-option-b-participation-and-breastfeeding-duration-among-hiv-positive-women-in-lilongwe-district-malawi-a-qualitative-study
#17
Valerie L Flax, Gloria Hamela, Innocent Mofolo, Mina C Hosseinipour, Irving F Hoffman, Suzanne Maman
To ensure the health of mothers and children, prevention of mother-to-child HIV transmission (PMTCT) programs test women for HIV, engage HIV-positive women in care, and promote recommended breastfeeding practices. Under Malawi's Option B+ PMTCT program, ~20% of women are lost-to-follow-up (LTFU) and little is known about their breastfeeding practices. The purpose of this study is to describe facilitators and barriers to Option B+ participation and how participation influences breastfeeding duration. We conducted in-depth interviews with HIV-positive women in Option B+ (n = 32) or LTFU from Option B+ (n = 32)...
2017: PloS One
https://www.readbyqxmd.com/read/28407452/uptake-and-performance-of-prevention-of-mother-to-child-transmission-and-early-infant-diagnosis-in-pregnant-hiv-infected-women-and-their-exposed-infants-at-seven-health-centres-in-addis-ababa-ethiopia
#18
Marshet Girma, Rahel Wendaferash, Hailu Shibru, Yemane Berhane, Michael Hoelscher, Arne Kroidl
OBJECTIVE: To assess the uptake of WHO-recommended PMTCT procedures in Ethiopia's health services. METHODS: Prospective observational study of HIV-positive pregnant mothers and their newborns attending PMTCT services at seven health centres in Addis Ababa. Women were recruited during antenatal care and followed-up with their newborns at delivery, day 6 and week 6 postpartum. Retention to PMCTC procedures, self-reported ART adherence, and HIV infant outcome were assessed...
April 13, 2017: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/28398999/confronting-challenges-in-monitoring-and-evaluation-innovation-in-the-context-of-the-global-plan-towards-the-elimination-of-new-hiv-infections-among-children-by-2015-and-keeping-their-mothers-alive
#19
Anna K Radin, Andrew A Abutu, Margaret A Okwero, Michelle R Adler, Chukwuma Anyaike, Hilda T Asiimwe, Prosper Behumbiize, Timothy A Efuntoye, Rachel L King, Linda Nabitaka Kisaakye, Dolapo T Ogundehin, Benjamin Ryan Phelps, Heather Watts, Fitti Weissglas
The Global Plan Towards the Elimination of New HIV Infections Among Children by 2015 and Keeping Their Mothers Alive (Global Plan), which was launched in 2011, set a series of ambitious targets, including a reduction of new HIV infections among children by 90% by 2015 (from a baseline year of 2009) and AIDS-related maternal mortality by 50% by 2015. To reach these targets, the Global Plan called for unprecedented investments in the prevention of mother-to-child transmission of HIV (PMTCT), innovative new approaches to service delivery, immense collective effort on the programmatic and policy fronts, and importantly, a renewed focus on data collection and use...
May 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28398996/lessons-learned-from-option-b-in-the-evolution-toward-test-and-start-from-malawi-cameroon-and-the-united-republic-of-tanzania
#20
Thokozani Kalua, Beth A Tippett Barr, Joep J van Oosterhout, Dorothy Mbori-Ngacha, Erik J Schouten, Sundeep Gupta, Amakobe Sande, Gerald Zomba, Hannock Tweya, Edgar Lungu, Deborah Kajoka, Pius Tih, Andreas Jahn
The acceleration of prevention of mother-to-child transmission (PMTCT) activities, coupled with the rollout of 2010 World Health Organization (WHO) guidelines, led to important discussions and innovations at global and country levels. One paradigm-shifting innovation was Option B+ in Malawi. It was later included in WHO guidelines and eventually adopted by all 22 Global Plan priority countries. This article presents Malawi's experience with designing and implementing Option B+ and provides complementary narratives from Cameroon and Tanzania...
May 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
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