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https://www.readbyqxmd.com/read/28546072/dendrimer-conjugated-peptide-vaccine-enhances-clearance-of-chlamydia-trachomatis-genital-infection
#1
Ingrid S Ganda, Qian Zhong, Mirabela Hali, Ricardo L C Albuquerque, Francine F Padilha, Sandro R P da Rocha, Judith A Whittum-Hudson
Peptide-based vaccines have emerged in recent years as promising candidates in the prevention of infectious diseases. However, there are many challenges to maintaining in vivo peptide stability and enhancement of peptide immunogenicity to generate protective immunity which enhances clearance of infections. Here, a dendrimer-based carrier system is proposed for peptide-based vaccine delivery, and shows its anti-microbial feasibility in a mouse model of Chlamydia trachomatis. Chlamydiae are the most prevalent sexually transmitted bacteria worldwide, and also the causal agent of trachoma, the leading cause of preventable infectious blindness...
May 22, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28542601/the-epidemiology-of-staphylococcus-aureus-carriage-in-patients-attending-inner-city-sexually-transmitted-infections-and-community-clinics-in-calgary-canada
#2
Alejandra Ugarte Torres, Angel Chu, Ron Read, Judy MacDonald, Daniel Gregson, Thomas Louie, Johanna Delongchamp, Linda Ward, Joann McClure, Kunyan Zhang, John Conly
BACKGROUND: Although the nares represent the most common carriage site for traditional hospital-associated strains of Staphylococcus aureus (SA), the predominant site of carriage of SA in the community is less certain. METHODS: We conducted a cross-sectional study in 285 patients attending sexually transmitted diseases and inner-city clinics to evaluate the prevalence, body site colonisation and risk factors associated with carriage of methicillin susceptible SA (MSSA)...
2017: PloS One
https://www.readbyqxmd.com/read/28542484/simulating-within-vector-generation-of-the-malaria-parasite-diversity
#3
Lauren M Childs, Olivia F Prosper
Plasmodium falciparum, the most virulent human malaria parasite, undergoes asexual reproduction within the human host, but reproduces sexually within its vector host, the Anopheles mosquito. Consequently, the mosquito stage of the parasite life cycle provides an opportunity to create genetically novel parasites in multiply-infected mosquitoes, potentially increasing parasite population diversity. Despite the important implications for disease transmission and malaria control, a quantitative mapping of how parasite diversity entering a mosquito relates to diversity of the parasite exiting, has not been undertaken...
2017: PloS One
https://www.readbyqxmd.com/read/28542366/illicit-drug-use-and-its-association-with-key-sexual-risk-behaviours-and-outcomes-findings-from-britain-s-third-national-survey-of-sexual-attitudes-and-lifestyles-natsal-3
#4
Rachelle Paquette, Clare Tanton, Fiona Burns, Philip Prah, Maryam Shahmanesh, Nigel Field, Wendy Macdowall, Kirsten Gravningen, Pam Sonnenberg, Catherine H Mercer
OBJECTIVES: We explore the hypothesis that using illicit drugs other than, or in addition to, cannabis is associated with sexual risk behaviour and sexual health outcomes in the British population. METHODS: We analysed data, separately by gender, reported by sexually-active participants (those reporting > = 1 partners/past year) aged 16-44 years (3,395 men, 4,980 women) in Britain's third National Survey of Sexual Attitudes and Lifestyles (Natsal-3), a probability survey undertaken 2010-12 involving computer-assisted personal-interview and computer-assisted self-interview...
2017: PloS One
https://www.readbyqxmd.com/read/28538901/sexually-transmitted-infections-and-pro-lives-based-on-a-clinical-report
#5
Paulo Eduardo Neves Ferreira Velho
Physicians are also responsible for the increase in sexually transmitted infections. We report a case of patient inadequately monitored, that shows the importance of physicians to take basic measures with any individual at risk of acquiring such infections. We propose the following mnemonic acrostic: PRO-LIVES (Protection: usual and proper codom use, Responsibility, Other orientations, Laboratory tests -HIV infection, syphilis and B and C hepatitis-, Immunization: B hepatitis vaccination, Various: at least two patients, Ensure: case history and physical examination, Single dose treatment: whenever possible)...
March 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28535758/hiv-prevalence-risky-behaviors-and-discrimination-experiences-among-transgender-women-in-cambodia-descriptive-findings-from-a-national-integrated-biological-and-behavioral-survey
#6
Siyan Yi, Chanrith Ngin, Sovannary Tuot, Pheak Chhoun, Srean Chhim, Khuondyla Pal, Phalkun Mun, Gitau Mburu
BACKGROUND: Transgender people are disproportionately affected by HIV. Despite their high vulnerability to HIV, lack of adequate epidemiological and surveillance data related to this population in many countries prevents provision of appropriate services. This paper summarizes descriptive findings from a national integrated biological and behavioral survey and discusses policy implications of the findings on HIV prevention among transgender women in Cambodia. METHODS: This cross-sectional study was conducted between December 2015 and February 2016...
May 23, 2017: BMC International Health and Human Rights
https://www.readbyqxmd.com/read/28534712/benefit-of-adjunct-universal-rectal-screening-for-chlamydia-genital-infections-in-women-attending-canadian-sexually-transmitted-infection-clinics
#7
Nguyen X Thanh, Ilke Akpinar, Jennifer Gratrix, Sabrina Plitt, Petra Smyczek, Ron Read, Philip Jacobs, Tom Wong, Ameeta E Singh
Adding universal rectal screening to urogenital screening should positively impact rectal Chlamydia trachomatis (CT) incidence in affected populations. A dynamic Markov model was used to evaluate costs and outcomes of three rectal CT screening strategies among women attending sexually transmitted infection clinics in Alberta, Canada: universal urogenital-only screening (UG-only), additional selected (exposure-based) rectal screening (UG+SR), and additional universal rectal screening (UG+UR). The model included two mutually exclusive health states: infected and susceptible...
January 1, 2017: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/28534540/-characterising-people-who-demanded-the-rapid-hiv-test-in-andalusia-between-2013-and-2014
#8
N Lorusso, F Lozano de León-Naranjo, C Zamora Fuentes
BACKGROUND: The aim of the study was to describe people who demanded the HIV screening test in Andalusia (Spain). DESIGN: Cross-sectional study carried out by social organisation collaborating with the Program for early diagnosis of HIV in Andalusia. Participants underwent an oral HIV test and answered a survey beforehand, from September 2013 to August 2014. The study included a descriptive analysis of data and a logistic regression in order to determine the risk factors associated with a reactive test result...
April 30, 2017: Anales del Sistema Sanitario de Navarra
https://www.readbyqxmd.com/read/28532649/condom-availability-in-schools-a-practical-approach-to-the-prevention-of-sexually-transmitted-infection-hiv-and-unintended-pregnancy
#9
(no author information available yet)
Adolescents and young adults are highly impacted by sexually transmitted infections (STIs) and unplanned pregnancy in the United States and globally. Consistent and correct use of male latex condoms is associated with protection against both STIs and pregnancy. Providing adolescents and young adults with access to free condoms in schools may increase the use of condoms by improving condom availability, eliminating cost, and decreasing embarrassment associated with purchasing condoms. Studies demonstrate that condom availability in schools is associated with the increased use of condoms and improved overall sexual health...
June 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/28532296/recently-released-black-men-s-perceptions-of-the-impact-of-incarceration-on-sexual-partnering
#10
Julie C Fields, Kelly M King, Kamila A Alexander, Katherine C Smith, Susan G Sherman, Amy Knowlton
Evidence suggests that men with recent histories of incarceration are more likely to engage in high-risk sexual activity, however there is limited research exploring how having been recently released from prison might impact men's sexual risk behaviours or sexual partnering. This qualitative study explores the ways in which exposure to incarceration impacts the dynamics of sexual partnering among recently released Black men in Baltimore, USA. In-depth interviews were conducted with 19 recently released Black men between 21-45 years of age living in the city...
May 23, 2017: Culture, Health & Sexuality
https://www.readbyqxmd.com/read/28532198/provider-perceptions-on-hiv-risk-and-prevention-services-within-permanent-supportive-housing
#11
Suzanne L Wenzel, Benjamin Henwood, Taylor Harris, Hailey Winetrobe, Harmony Rhoades
Permanent supportive housing (PSH) is an evidence-based solution to homelessness for persons experiencing chronic or long-term homelessness and one or more physical or behavioral health problems. Health services through PSH typically focus on physical and behavioral health. With the exception of programs specifically designed for persons living with HIV/AIDS, little attention has focused on services through PSH to prevent transmission of HIV or other sexually transmitted infections (STIs), yet sexual risk behavior continues after homeless persons move into PSH...
May 22, 2017: AIDS Care
https://www.readbyqxmd.com/read/28531212/epidemiological-investigation-of-the-relationship-between-common-lower-genital-tract-infections-and-high-risk-human-papillomavirus-infections-among-women-in-beijing-china
#12
Dai Zhang, Ting Li, Lei Chen, Xiaosong Zhang, Gengli Zhao, Zhaohui Liu
BACKGROUND: The incidence of lower genital tract infections in China has been increasing in recent years. The link between high-risk human papillomavirus (HR-HPV) and other sexually transmitted diseases (STDs) remains unclear. METHODS: From March to October 2014, gynecological examinations and questionnaires were conducted on 1218 married women. Cervical secretions and vaginal swab specimens were tested for Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG), Ureaplasma urealyticum (UU), yeast, clue cells and HR-HPV...
2017: PloS One
https://www.readbyqxmd.com/read/28530499/the-duality-of-oral-sex-for-men-who-have-sex-with-men-an-examination-into-the-increase-of-sexually-transmitted-infections-amid-the-age-of-hiv-prevention
#13
Tiffany R Glynn, Don Operario, Madeline Montgomery, Alexi Almonte, Philip A Chan
Several studies suggest that the increase in sexually transmitted infections (STIs) among men who have sex with men (MSM) could be due, in part, to human immunodeficiency virus (HIV) risk reduction strategies, which include engaging in oral sex over anal sex. The aims of this study were to evaluate oral sex behaviors and STI diagnoses and to investigate the potential dual role of oral sex as being protective for HIV, yet perpetuating STI transmission among MSM. We analyzed records from 871 MSM presenting to the Rhode Island STI Clinic between 2012 and 2015...
May 22, 2017: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/28529400/long-term-consequences-of-early-sexual-initiation-on-young-adult-health-a-causal-inference-approach
#14
Kari C Kugler, Sara A Vasilenko, Nicole M Butera, Donna L Coffman
Although early sexual initiation has been linked to negative outcomes, it is unknown whether these effects are causal. In this study, we use propensity score methods to estimate the causal effect of early sexual initiation on young adult sexual risk behaviors and health outcomes using data from the National Longitudinal Study of Adolescent to Adult Health. We found that early sexual initiation predicted having 2 or more partners (for both males and females) and having a sexually transmitted infection in the past year (females only) but did not predict depressive symptoms in the past week (for either gender)...
May 2017: Journal of Early Adolescence
https://www.readbyqxmd.com/read/28528686/hpv-entry-into-cells
#15
REVIEW
Pinar Aksoy, Elinor Y Gottschalk, Patricio I Meneses
Human papillomavirus (HPV) is a sexually transmitted virus responsible for the development of cervical cancer, anal cancer, head and throat cancers, as well as genital area warts. A major focus of current HPV research is on preventing the virus from entering a cell and transferring its genetic material to the nucleus, thus potentially preventing the development of cancer. Although the available HPV vaccines are extremely successful, approximately 15 additional cancer-causing HPVs have been identified that the vaccines do not protect against...
April 2017: Mutation Research
https://www.readbyqxmd.com/read/28528588/anorectal-swabs-as-a-marker-of-male-to-male-sexual-exposure-in-sti-surveillance-systems
#16
F H Ampt, C El Hayek, P A Agius, A L Bowring, N Bartnik, C VAN Gemert, C K Fairley, E P F Chow, C S Bradshaw, N Stephens, M S C Lim, M E Hellard
Identification of priority populations such as men who have sex with men (MSM) is important in surveillance systems to monitor trends of sexually transmitted infections (STIs). We explored using routinely collected non-behavioural data as a means to establish MSM status in surveillance by assessing anorectal swab as a marker of male-to-male sexual exposure. We used chlamydia testing data from a sexual health clinic, 2007-2012. Men reporting any male sexual partner(s) in the previous 12 months were considered MSM...
May 22, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28528207/interventions-to-increase-male-attendance-and-testing-for-sexually-transmitted-infections-at-publicly-funded-family-planning-clinics
#17
David Fine, Lee Warner, Sarah Salomon, David M Johnson
PURPOSE: We assessed the impact of staff, clinic, and community interventions on male and female family planning client visit volume and sexually transmitted infection testing at a multisite community-based health care agency. METHODS: Staff training, clinic environmental changes, in-reach/outreach, and efficiency assessments were implemented in two Family Health Center (San Diego, CA) family planning clinics during 2010-2012; five Family Health Center family planning programs were identified as comparison clinics...
May 17, 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/28521722/prevalence-and-risk-factors-for-human-immunodeficiency-virus-hiv-and-syphilis-infections-among-military-personnel-in-sierra-leone
#18
Djeneba Audrey Djibo, Foday Sahr, J Allen McCutchan, Sonia Jain, Maria Rosario G Araneta, Stephanie K Brodine, Richard A Shaffer
CONTEXT: HIV and syphilis infections are common in military personnel in sub-Saharan Africa, which impact combat preparedness and increase demands on the military health care system. The prevalence of HIV is estimated at 1.5% among the general population (15-49 years of age) of Sierra Leone, and the estimated syphilis prevalence ranged from 1.5% to 5.2% based on regional studies. We examined the prevalence and risk factors for these two common sexually transmitted infections in the Sierra Leone military personnel...
May 16, 2017: Current HIV Research
https://www.readbyqxmd.com/read/28521713/global-hiv-prevention-testing-and-counseling-in-military-populations
#19
Michael P Grillo, Margo Sloan, Che Wankie, Kelly Woodland, Elizabeth Reader, Bruce Porter, Richard Shaffer, Caroline A Macera, Marc Bulterys
BACKGROUND: Compared with the general population in low- and middle-income countries, military members tend to be male, young, travel more frequently away from their main sexual partners, drink more alcohol and have a consistent source of income. All of these factors may lead to an increased risk of contracting HIV. OBJECTIVE: In response, the Department of Defense HIV/AIDS Prevention Program advocates for the integration of HIV prevention "building blocks" into military health services to reduce the risk of acquiring HIV among foreign uniformed services...
May 16, 2017: Current HIV Research
https://www.readbyqxmd.com/read/28520925/the-ironclad-truth-how-in-vivo-transcriptomics-and-in-vitro-mechanistic-studies-shape-our-understanding-of-neisseria-gonorrhoeae-gene-regulation-during-mucosal-infection
#20
Matthew R Moreau, Paola Massari, Caroline A Genco
Neisseria gonorrhoeae is one of the most prevalent sexually transmitted infections worldwide. This obligate human pathogen has been extensively studied in vitro, where bacterial factors that are known to contribute to gonococcal disease and their regulation are relatively well defined. However, these in vitro experimental conditions only loosely replicate the host specific environment encountered by the bacteria in vivo. We recently reported on the complete gonococcal transcriptome expressed during natural human mucosal infection using RNA-seq analysis...
May 17, 2017: Pathogens and Disease
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