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https://www.readbyqxmd.com/read/28089784/axillary-management-of-stage-ii-iii-breast-cancer-patients-treated-with-neoadjuvant-systemic-therapy-results-of-calgb-40601-her2-positive-and-calgb-40603-triple-negative
#1
David W Ollila, Constance T Cirrincione, Donald A Berry, Lisa A Carey, William M Sikov, Clifford A Hudis, Eric P Winer, Mehra Golshan
OBJECTIVES: Management of the axilla in stage II/III breast cancer undergoing neoadjuvant systemic therapy (NST) is controversial. To understand current patterns of care, we collected axillary data from two NST trials: HER2-positive (CALGB40601) and triple-negative (CALGB40603). METHODS: Axillary evaluation pre-/post-NST was per the treating surgeon and could include sentinel node biopsy (SNB). Post-NST, node-positive patients were recommended to undergo axillary lymph node dissection (ALND)...
January 12, 2017: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/28007623/small-cell-lung-cancer-exhibits-frequent-inactivating-mutations-in-the-histone-methyltransferase-kmt2d-mll2-calgb-151111-alliance
#2
Arnaud Augert, Qing Zhang, Breanna Bates, Min Cui, Xiaofei Wang, Gary Wildey, Afshin Dowlati, David MacPherson
INTRODUCTION: Small cell lung carcinoma (SCLC) is a lethal neuroendocrine tumor type, highly prone to metastasis. There is an urgency to understand the mutated genes that promote SCLC, as there are no approved targeted therapies yet available. SCLC is rarely resected, limiting the number of samples available for genomic analyses of somatic mutations. METHODS: To identify potential driver mutations in human SCLC we sequenced the whole exomes of 18 primary SCLCs and 7 cell lines along with matched normal controls...
December 19, 2016: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/27972465/bevacizumab-in-the-treatment-of-kras-wild-type-metastatic-colorectal-cancer-an-economic-analysis-based-on-the-calgb-80405-trial
#3
C Silva, I Monteiro, C Tournier
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27967294/patterns-of-growth-factor-usage-and-febrile-neutropenia-among-older-patients-with-diffuse-large-b-cell-non-hodgkin-lymphoma-treated-with-chop-or-r-chop-the-intergroup-experience-calgb-9793-ecog-swog-4494
#4
Vicki A Morrison, Edie A Weller, Thomas M Habermann, Shuli Li, Richard I Fisher, Bruce D Cheson, Bruce A Peterson
Patterns of myeloid growth factor (GF) usage and febrile neutropenia (FN) were examined in patients >60 years of age with diffuse large B-cell non-Hodgkin lymphoma (DLBCL) enrolled on CALGB 9793/ECOG-SWOG 4494, receiving initial therapy with cyclophosphamide, doxorubicin, vincristine, prednisone (CHOP) or rituximab + CHOP (R-CHOP). Myeloid GFs were administered to 256/520 (49%) patients. Indications for use were: prevent dose reduction/dose delay (81%, 207/256); treat FN or non-febrile neutropenia (NFN) (19%, 48/256)...
December 14, 2016: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/27907852/the-relevance-of-primary-tumour-location-in-patients-with-metastatic-colorectal-cancer-a-meta-analysis-of-first-line-clinical-trials
#5
Julian Walter Holch, Ingrid Ricard, Sebastian Stintzing, Dominik Paul Modest, Volker Heinemann
BACKGROUND: Retrospective subgroup analyses suggest that primary tumour location (PTL) has a prognostic importance and relates to response to targeted therapy. METHODS: We conducted a meta-analysis of first-line clinical trials available up to October 2016, which assessed the relevance of PTL in patients with metastatic colorectal cancer (mCRC). Right- and left-sided colorectal cancers were differentiated (RC and LC). RESULTS: In 13 first-line randomised controlled trials and one prospective pharmacogenetic study, RC was associated with a significantly worse prognosis compared with LC (hazard ratio [HR] for overall survival: 1...
January 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/27866278/risk-of-acute-myeloid-leukemia-and-myelodysplastic-syndrome-among-older-women-receiving-anthracycline-based-adjuvant-chemotherapy-for-breast-cancer-on-modern-cooperative-group-trials-alliance-a151511
#6
Rachel A Freedman, D K Seisler, J C Foster, J A Sloan, J M Lafky, G G Kimmick, A Hurria, H J Cohen, E P Winer, C A Hudis, A H Partridge, L A Carey, A Jatoi, H D Klepin, M Citron, D A Berry, L N Shulman, A U Buzdar, V J Suman, H B Muss
PURPOSE: We examined acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) events among 9679 women treated for breast cancer on four adjuvant Alliance for Clinical Trials in Oncology trials with >90 months of follow-up in order to better characterize the risk for AML/MDS in older patients receiving anthracyclines. METHODS: We used multivariable Cox regression to examine factors associated with AML/MDS, adjusting for age (≥65 vs. <65 years; separately for ≥70 vs...
January 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/27704226/impact-of-neoadjuvant-therapy-on-eligibility-for-and-frequency-of-breast-conservation-in-stage-ii-iii-her2-positive-breast-cancer-surgical-results-of-calgb-40601-alliance
#7
Mehra Golshan, Constance T Cirrincione, William M Sikov, Lisa A Carey, Donald A Berry, Beth Overmoyer, Nora L Henry, George Somlo, Elisa Port, Harold J Burstein, Clifford Hudis, Eric Winer, David W Ollila
OBJECTIVE: It had been previously shown that patients who receive neoadjuvant systemic therapy (NST) are more likely to undergo breast-conserving therapy (BCT) than those who have primary surgery. However, the frequency with which patients who are not BCT-eligible prior to NST convert to BCT-eligible with treatment is unknown. To document this conversion rate in a subset of patients expected to have a high clinical response rate to NST, we studied surgical assessment and management of patients enrolled on a randomized neoadjuvant trial for stage II-III HER2-positive breast cancer (HER2 + BC)(CALGB 40601)...
November 2016: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/27624549/maintenance-therapy-with-decitabine-in-younger-adults-with-acute-myeloid-leukemia-in-first-remission-a-phase-2-cancer-and-leukemia-group-b-study-calgb-10503
#8
W Blum, B L Sanford, R Klisovic, D J DeAngelo, G Uy, B L Powell, W Stock, M R Baer, J E Kolitz, E S Wang, E Hoke, K Mrózek, J Kohlschmidt, C D Bloomfield, S Geyer, G Marcucci, R M Stone, R A Larson
In this prospective phase 2 clinical trial conducted by Cancer and Leukemia Group B (CALGB, now the Alliance), we studied decitabine as maintenance therapy for younger adults with acute myeloid leukemia (AML) who remained in first complete remission (CR1) following intensive induction and consolidation. Given that decitabine is clinically active in AML and with hypomethylating activity distinct from cytotoxic chemotherapy, we hypothesized that 1 year of maintenance therapy would improve disease-free survival (DFS) for AML patients <60 years, who did not receive allogeneic stem cell transplantation in CR1...
January 2017: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/27621868/validation-of-eortc-and-calgb-prognostic-models-in-surgical-patients-submitted-to-diagnostic-palliative-or-curative-surgery-for-malignant-pleural-mesothelioma
#9
Alberto Sandri, Francesco Guerrera, Matteo Roffinella, Stefania Olivetti, Lorena Costardi, Alberto Oliaro, Pier Luigi Filosso, Paolo Olivo Lausi, Enrico Ruffini
BACKGROUND: To assess the trend of our surgical patients affected by malignant pleural mesothelioma (MPM) and submitted to diagnostic/palliative or curative surgical procedures and to validate the European Organisation for Research and Treatment of Cancer (EORTC) prognostic score in our patient population. METHODS: This is a cohort study of patients submitted to surgery for MPM from January 2007 to December 2013. Primary outcome was overall survival (OS). Univariate and multivariate-adjusted comparisons by EORTC prognostic score for OS were accomplished using Cox method...
August 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/27470602/chromosome-abnormalities-at-onset-of-complete-remission-are-associated-with-worse-outcome-in-patients-with-acute-myeloid-leukemia-and-an-abnormal-karyotype-at-diagnosis-calgb-8461-alliance
#10
Christian Niederwieser, Deedra Nicolet, Andrew J Carroll, Jonathan E Kolitz, Bayard L Powell, Jessica Kohlschmidt, Richard M Stone, John C Byrd, Krzysztof Mrózek, Clara D Bloomfield
Achievement of complete remission is essential for long-term survival of acute myeloid leukemia patients. We evaluated the prognostic significance of cytogenetics at complete remission in 258 adults with de novo acute myeloid leukemia and abnormal pre-treatment karyotypes, treated on Cancer and Leukemia Group B front-line studies, with cytogenetic data at onset of morphological complete remission. Thirty-two patients had abnormal karyotypes at time of initial complete remission. Of these, 28 had at least 1 abnormality identified pre-treatment, and 4 acute myeloid leukemia-related abnormalities not detected pre-treatment...
December 2016: Haematologica
https://www.readbyqxmd.com/read/27465221/blood-based-markers-of-efficacy-and-resistance-to-cetuximab-treatment-in-metastatic-colorectal-cancer-results-from-calgb-80203-alliance
#11
Ace J Hatch, Alexander B Sibley, Mark D Starr, J Chris Brady, Chen Jiang, Jingquan Jia, Daniel L Bowers, Herbert Pang, Kouros Owzar, Donna Niedzwiecki, Federico Innocenti, Alan P Venook, Herbert I Hurwitz, Andrew B Nixon
Circulating protein markers were assessed in patients with colorectal cancer (CRC) treated with cetuximab in CALGB 80203 to identify prognostic and predictive biomarkers. Patients with locally advanced or metastatic CRC received FOLFOX or FOLFIRI chemotherapy (chemo) or chemo in combination with cetuximab. Baseline plasma samples from 152 patients were analyzed for six candidate markers [epidermal growth factor (EGF), heparin-binding EGF (HBEGF), epidermal growth factor receptor (EGFR), HER2, HER3, and CD73]...
September 2016: Cancer Medicine
https://www.readbyqxmd.com/read/27449492/impact-of-race-ethnicity-and-bmi-on-achievement-of-pathologic-complete-response-following-neoadjuvant-chemotherapy-for-breast-cancer-a-pooled-analysis-of-four-prospective-alliance-clinical-trials-a151426
#12
Erica T Warner, Karla V Ballman, Carrie Strand, Judy C Boughey, Aman U Buzdar, Lisa A Carey, William M Sikov, Ann H Partridge
Previous studies demonstrated poor response to neoadjuvant systemic therapy (NST) for breast cancer among black women and women who are overweight or obese, but this may be due to chemotherapy underdosing. We assessed associations of race, ethnicity, and body mass index (BMI) with pathologic complete response (pCR) in clinical trial populations. 1797 women enrolled in four NST trials (CALGB 40601, 40603; ACOSOG Z1041, Z1071) were included. Tumor subtypes were defined by estrogen receptor (ER) and HER2 status...
August 2016: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/27447359/long-term-trajectories-of-self-reported-cognitive-function-in-a-cohort-of-older-survivors-of-breast-cancer-calgb-369901-alliance
#13
Jeanne S Mandelblatt, Jonathan D Clapp, Gheorghe Luta, Leigh Anne Faul, Michelle D Tallarico, Trina D McClendon, Jessica A Whitley, Ling Cai, Tim A Ahles, Robert A Stern, Paul B Jacobsen, Brent J Small, Brandelyn N Pitcher, Estrella Dura-Fernandis, Hyman B Muss, Arti Hurria, Harvey J Cohen, Claudine Isaacs
BACKGROUND: The number of survivors of breast cancer aged ≥65 years ("older") is growing, but to the authors' knowledge, little is known regarding the cognitive outcomes of these individuals. METHODS: A cohort of cognitively intact older survivors with nonmetastatic, invasive breast cancer was recruited from 78 sites from 2004 through 2011; approximately 83.7% of the survivors (1280 survivors) completed baseline assessments. Follow-up data were collected at 6 months and annually for up to 7 years (median, 4...
July 22, 2016: Cancer
https://www.readbyqxmd.com/read/27399059/economic-evaluation-study-cheer-compliant-cost-effectiveness-analysis-of-ras-screening-for-treatment-of-metastatic-colorectal-cancer-based-on-the-calgb-80405-trial
#14
Jing Zhou, Rongce Zhao, Feng Wen, Pengfei Zhang, Ruilei Tang, Hongdou Chen, Jian Zhang, Qiu Li
Cetuximab (Cetux)/Bevacizumab (Bev) treatments have shown considerably survival benefits for patients with metastatic colorectal cancer (mCRC) in the last decade. But they are costly. Currently, no data is available on the health economic implications of testing for extended RAS wild-type (wt) prior to Cetux/Bev treatments of patients with mCRC. This paper aimed to evaluate the cost-effectiveness of predictive testing for extended RAS-wt status in mCRC in the context of targeting the use of Cetux/Bev.Markov model 1 was conducted to provide evidence evaluating the cost-effectiveness of predictive testing for KRAS-wt or extended RAS-wt status based on treatments of chemotherapy plus Cetux/Bev...
July 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27382098/calgb-80403-alliance-e1206-a-randomized-phase-ii-study-of-three-chemotherapy-regimens-plus-cetuximab-in-metastatic-esophageal-and-gastroesophageal-junction-cancers
#15
Peter C Enzinger, Barbara Ann Burtness, Donna Niedzwiecki, Xing Ye, Kathe Douglas, David H Ilson, Victoria Meucci Villaflor, Steven J Cohen, Robert J Mayer, Alan Venook, Al Bowen Benson, Richard M Goldberg
PURPOSE: To determine the optimal chemotherapy backbone for testing in future US cooperative group studies for metastatic esophageal and gastroesophageal junction cancers. Cetuximab was added to each treatment arm based on promising preclinical data. PATIENTS AND METHODS: Patients with previously untreated metastatic esophageal or gastroesophageal junction cancer were randomly assigned at a one-to-one-to-one ratio to epirubicin, cisplatin, and continuous-infusion fluorouracil (ECF), irinotecan plus cisplatin (IC), or FOLFOX (oxaliplatin, leucovorin, and bolus and infusional fluorouracil)...
August 10, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/27143689/pharmacogenetic-discovery-in-calgb-alliance-90401-and-mechanistic-validation-of-a-vac14-polymorphism-that-increases-risk-of-docetaxel-induced-neuropathy
#16
Daniel L Hertz, Kouros Owzar, Sherrie Lessans, Claudia Wing, Chen Jiang, William Kevin Kelly, Jai Patel, Susan Halabi, Yoichi Furukawa, Heather E Wheeler, Alexander B Sibley, Cameron Lassiter, Lois Weisman, Dorothy Watson, Stefanie D Krens, Flora Mulkey, Cynthia L Renn, Eric J Small, Phillip G Febbo, Ivo Shterev, Deanna L Kroetz, Paula N Friedman, John F Mahoney, Michael A Carducci, Michael J Kelley, Yusuke Nakamura, Michiaki Kubo, Susan G Dorsey, M Eileen Dolan, Michael J Morris, Mark J Ratain, Howard L McLeod
PURPOSE: Discovery of SNPs that predict a patient's risk of docetaxel-induced neuropathy would enable treatment individualization to maximize efficacy and avoid unnecessary toxicity. The objectives of this analysis were to discover SNPs associated with docetaxel-induced neuropathy and mechanistically validate these associations in preclinical models of drug-induced neuropathy. EXPERIMENTAL DESIGN: A genome-wide association study was conducted in metastatic castrate-resistant prostate cancer patients treated with docetaxel, prednisone and randomized to bevacizumab or placebo on CALGB 90401...
October 1, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/27138575/phase-iii-trial-evaluating-letrozole-as-first-line-endocrine-therapy-with-or-without-bevacizumab-for-the-treatment-of-postmenopausal-women-with-hormone-receptor-positive-advanced-stage-breast-cancer-calgb-40503-alliance
#17
Maura N Dickler, William T Barry, Constance T Cirrincione, Matthew J Ellis, Mary Ellen Moynahan, Federico Innocenti, Arti Hurria, Hope S Rugo, Diana E Lake, Olwen Hahn, Bryan P Schneider, Debasish Tripathy, Lisa A Carey, Eric P Winer, Clifford A Hudis
PURPOSE: To investigate whether anti-vascular endothelial growth factor therapy with bevacizumab prolongs progression-free survival (PFS) when added to first-line letrozole as treatment of hormone receptor-positive metastatic breast cancer (MBC). PATIENTS AND METHODS: Women with hormone receptor-positive MBC were randomly assigned 1:1 in a multicenter, open-label, phase III trial of letrozole (2.5 mg orally per day) with or without bevacizumab (15 mg/kg intravenously once every 3 weeks) within strata defined by measurable disease and disease-free interval...
August 1, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/27019981/expression-and-polymorphism-rs4880-of-mitochondrial-superoxide-dismutase-sod2-and-asparaginase-induced-hepatotoxicity-in-adult-patients-with-acute-lymphoblastic-leukemia
#18
H Alachkar, N Fulton, B Sanford, G Malnassy, M Mutonga, R A Larson, C D Bloomfield, G Marcucci, Y Nakamura, W Stock
Asparaginase, which depletes asparagine and glutamine, activates amino-acid stress response. Oxidative stress mediated by excessive reactive oxygen species (ROS) causes enhanced mitochondrial permeabilization and subsequent cell apoptosis and is considered as a plausible mechanism for drug-induced hepatotoxicity, a common toxicity of asparaginase in adults with acute lymphoblastic leukemia (ALL). Studies investigating the pharmacogenetics of asparaginase in ALL are limited and focused on asparaginase-induced allergic reaction common in pediatric patients...
March 29, 2016: Pharmacogenomics Journal
https://www.readbyqxmd.com/read/26972498/words-of-wisdom-re-randomized-controlled-trial-of-early-zoledronic-acid-in-men-with-castration-sensitive-prostate-cancer-and-bone-metastases-results-of-calgb-90202-alliance
#19
COMMENT
https://www.readbyqxmd.com/read/26968417/neoadjuvant-treatment-of-high-risk-clinically-localized-prostate-cancer-prior-to-radical-prostatectomy
#20
REVIEW
Eugene J Pietzak, James A Eastham
Multimodal strategies combining local and systemic therapy offer the greatest chance of cure for many with men with high-risk prostate cancer who may harbor occult metastatic disease. However, no systemic therapy combined with radical prostatectomy has proven beneficial. This was in part due to a lack of effective systemic agents; however, there have been several advancements in the metastatic and castrate-resistant prostate cancer that might prove beneficial if given earlier in the natural history of the disease...
May 2016: Current Urology Reports
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