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Sarah Caldwell, Katie Wusik, Hua He, Geoffrey Yager, Carrie Atzinger
The purpose of this study was to determine if a genetic counseling student's perception of the supervisory working alliance (SWA) is related to their self-efficacy on select clinical practice-based competencies (PBCs), evaluating the second tenet of the Reciprocal Engagement Model of Supervision (REM-S) from a student perspective. Second year genetic counseling students (N = 168) completed a survey containing demographic and clinical rotation experience questions, the Supervisory Working Alliance Inventory-Trainee Form (SWAI-T), and the Genetic Counseling Self-Efficacy Scale (GCSES)...
June 22, 2018: Journal of Genetic Counseling
Larissa Alice Dreier, Julia Wager, Markus Blankenburg, Boris Zernikow
A high prevalence of sleep problems exists in children and adolescents with life-limiting conditions (LLC) and severe psychomotor impairment (SPMI). This study aimed to compare the impacts of various child-related (pain, epilepsy, repositioning, medical care) and environment-related (light, noise, TV/radio, open door) factors on sleep in this vulnerable population. Data were obtained through the “Sleep Questionnaire for Children with Severe Psychomotor Impairment” (SNAKE) by proxy assessment...
June 21, 2018: Children
Frédéric Debellut, Nathaniel Hendrix, Justin R Ortiz, Philipp Lambach, Kathleen M Neuzil, Niranjan Bhat, Clint Pecenka
Immunization of pregnant women against seasonal influenza remains limited in low- and lower-middle-income countries despite being recommended by the World Health Organization (WHO). The WHO/PATH Maternal Influenza Immunization Project was created to identify and address obstacles to delivering influenza vaccines to pregnant women in low resource setting. To gain a better understanding of potential demand from this target group, we developed a model simulating pregnant women populations eligible for vaccination during antenatal care (ANC) services in all low- and lower-middle-income countries...
2018: PloS One
Samir Z Zard
The alkylation of enolates is one of the backbones of ketone chemistry, yet in practice it suffers from numerous limitations due to problems of regiochemistry (including O- versus C-alkylation), multiple alkylations, self-condensation, competing elimination, and incompatibility with many polar groups that have to be protected. Over the years, various solutions have been devised to overcome these difficulties, such as the employment of auxiliary ester or sulfone groups to modify the p Ka of the enolizable hydrogens, the passage by the corresponding hydrazones, the use of transition-metal-catalyzed redox systems to formally alkylate ketones with alcohols, etc...
June 22, 2018: Accounts of Chemical Research
Bianca Calabria, Rosemary J Korda, Raymond W Lovett, Peter Fernando, Tanya Martin, Leone Malamoo, Jennifer Welsh, Emily Banks
OBJECTIVE: To quantify absolute cardiovascular disease (CVD) risk in Aboriginal and Torres Strait Islander people and their use of lipid-lowering therapies. DESIGN, PARTICIPANTS: Cross-sectional analysis of nationally representative data from 2820 participants aged 18-74 years who provided biomedical data for the National Aboriginal and Torres Strait Islander Health Measures Survey component of the 2012-13 Australian Aboriginal and Torres Strait Islander Health Survey...
June 25, 2018: Medical Journal of Australia
Katherine L Martin, Ryan E Emanuel, James M Vose
Concentrated animal feeding operations (CAFOs) pose wide ranging environmental risks to many parts of the US and across the globe, but datasets for CAFO risk assessments are not readily available. Within the United States, some of the greatest concentrations of CAFOs occur in North Carolina. It is also one of the only states with publicly accessible location data for classes of CAFOs that are required to obtain water quality permits from the U.S. Environmental Protection Agency (EPA); however, there are no public data sources for the large number of CAFOs that do not require EPA water quality permits...
June 18, 2018: Science of the Total Environment
Gurdeeshpal Randhawa, Ataa Azarbar, Huiru Dong, M J Milloy, Thomas Kerr, Kanna Hayashi
Childhood traumatic experiences can disrupt attachment, influence personality development, and precipitate chronic disease. Although the repercussions of these experiences may also pose a barrier to healthcare, few studies have examined the association between childhood trauma and access to healthcare. Therefore, we sought to investigate whether a history of childhood trauma is associated with self-reported inability to access hospital care among persons who inject drugs (PWID). Data were derived from two prospective cohorts of PWID in Vancouver, Canada...
June 20, 2018: Journal of Traumatic Stress
Ye Jee Shim, Jae Min Lee, Heung Sik Kim, Nani Jung, Young Tak Lim, Eu Jeen Yang, Jeong Ok Hah, Young-Ho Lee, Hee Won Chueh, Jae Young Lim, Eun Sil Park, Jeong A Park, Ji Kyoung Park, Sang Kyu Park
We compared transplant outcomes between donor types and stem cell sources for childhood acute myeloid leukemia (AML). The medical records of children with AML in the Yeungnam region of Korea from January 2000 to June 2017 were reviewed. In all, 76 children with AML (male-to-female ratio = 46:30) received allogenic hematopoietic stem cell transplantation (allo-HSCT). In total, 29 patients received HSCT from either a matched-related donor or a mismatched-related donor, 32 patients received an unrelated donor, and 15 patients received umbilical cord blood...
June 19, 2018: Pediatric Transplantation
Rebecca Elvey, Simon Bailey, Kath Checkland, Anne McBride, Stephen Parkin, Katy Rothwell, Damian Hodgson
BACKGROUND: Current health policy focuses on improving accessibility, increasing integration and shifting resources from hospitals to community and primary care. Initiatives aimed at achieving these policy aims have supported the implementation of various 'new models of care', including general practice offering 'additional availability' appointments during evenings and at weekends. In Greater Manchester, six 'demonstrator sites' were funded: four sites delivered additional availability appointments, other services included case management and rapid response...
June 19, 2018: BMC Family Practice
Luca Neri, Ketty Peris, Caterina Longo, Stefano Calvieri, Pasquale Frascione, Aurora Parodi, Eibenschuz Laura, Ugo Bottoni, Giovanni Pellacani
BACKGROUND: Patients with multiple actinic keratoses (AK) should be treated with field-directed therapy. Such treatments challenge patients' adherence due out-of-pocket costs, length of treatment and severity of Local Skin Reactions (LSRs). Effective physician-patient communication (PPC) may buffer therapy-related distress thus improving quality of life, treatment satisfaction and adherence. OBJECTIVES: We evaluated the interplay between PPC, LSR intensity (safety) and lesion clearance rates (effectiveness) on treatment satisfaction, quality of life and treatment adherence among patients with multiple AK receiving topical field-directed therapies...
June 19, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
Katherine Bain, Tessa Baradon
This article is part of a project investigating the interfacing of clinically and research-generated knowledge in the field of infant mental health (IMH) with local cultural models of child care and development. The article explores the experiences and challenges reported by psychology-trained supervisors in supervision with local, lay, trained home visitors. Supervisors and supervisees were drawn from two early intervention programs which apply relational IMH mental health models in socioeconomically deprived townships in South Africa...
June 19, 2018: Infant Mental Health Journal
Richard Ramsey
The perception of other people is instrumental in guiding social interactions. For example, the appearance of the human body cues a wide range of inferences regarding sex, age, health, and personality, as well as emotional state and intentions, which influence social behavior. To date, most neuroscience research on body perception has aimed to characterize the functional contribution of segregated patches of cortex in the ventral visual stream. In light of the growing prominence of network architectures in neuroscience, the current article reviews neuroimaging studies that measure functional integration between different brain regions during body perception...
June 19, 2018: Journal of Cognitive Neuroscience
Jingru Zhang, Yingqiao Wang, Jianxiang Wang, Jianda Hu, Suning Chen, Jie Jin, Ting Liu, Jianfeng Zhou, Yu Hu, Daoxin Ma, Xiaojun Huang, Chunyan Ji, Ming Hou
An early molecular response is spectacularly predictive of outcome in chronic myeloid leukemia (CML) and early response landmarks may identify the high-risk patients likely to be benefit from an early therapy switch. In this study, we evaluated the most relevant cutoffs for early molecular response markers (BCR-ABL1 values at 3 months, log reduction and halving time between diagnosis and 3 months) in 476 first-line imatinib-treated Chinese patients with chronic phase CML. All outcomes were significantly superior for the 324 patients with 3-month BCR-ABL1 ≤10%, so did for the 270 patients with BCR-ABL1 >0...
June 15, 2018: Blood Cancer Journal
Jason M Mwenda, Umesh D Parashar, Adam L Cohen, Jacqueline E Tate
By the end of 2017, 32 (68%) of 47 countries in the World Health Organization's African Region had introduced rotavirus vaccine into their national immunization programs, including 27 countries that received financial support from the Gavi, the Vaccine Alliance. Several early introducing African countries previously evaluated the impact, vaccine effectiveness, and/or cost effectiveness of their routine rotavirus vaccination programs and found that rotavirus vaccine was effective and resulted in substantial declines in hospitalizations due to rotavirus...
June 15, 2018: Vaccine
Aurelie M C Lange, Rachel E A van der Rijken, Marc J M H Delsing, Jan J V Busschbach, Ron H J Scholte
Therapist adherence to the treatment manual is assumed to be crucial for adequate implementation and subsequent achievement of the intended, positive treatment outcomes. Although adherence has been mostly studied as a static factor, recent studies suggest that adherence might be dynamic and changes over time. We investigated how parent-perceived adherence to the multisystemic therapy (MST) model develops during treatment and how this development is related to treatment outcomes up to 18 months posttreatment, controlling for the effect of alliance...
June 18, 2018: Journal of Clinical Child and Adolescent Psychology
Hiroshi Takasaki, Takahiro Miki, Toby Hall
BACKGROUND: Working alliance between the physiotherapist and patient is important for successful treatment in physiotherapy. Working alliance can be measured by a 12-item self-reporting measure with 7-point Likert scale, the Working Alliance Inventory Short-Form Client (WAI-SC). OBJECTIVES: To develop a shorter version of the Japanese WAI-SC through examination of factor structure and test-retest reliability. DESIGN: Survey. METHOD: A convenience sample of 118 outpatients with musculoskeletal disorders completed the WAI-SC immediately after the third consultation and 101 of them completed the WAI-SC immediately before the fourth consultation...
June 18, 2018: Physiotherapy Theory and Practice
Sebastian Euler, Johannes Wrege, Mareike Busmann, Hannah J Lindenmeyer, Daniel Sollberger, Undine E Lang, Jens Gaab, Marc Walter
Interpersonal sensitivity, particularly threat of potential exclusion, is a critical condition in borderline personality disorder (BPD) which impairs patients' social adjustment. Current evidence-based treatments include group components, such as mentalization-based group therapy (MBT-G), in order to improve interpersonal functioning. These treatments additionally focus on the therapeutic alliance since it was discovered to be a robust predictor of treatment outcome. However, alliance is a multidimensional factor of group therapy, which includes the fellow patients, and may thus be negatively affected by the exclusion-proneness of BPD patients...
2018: Frontiers in Psychology
Deirdre Richardson, Simon Adamson, Daryle Deering
INTRODUCTION: The pan-theoretical variable of alliance has been consistently reported to have a moderate yet robust effect on psychotherapy treatment outcome. However, the relationship is less clear in the addiction field where there is more limited research. The current study investigated the relationship between alliance and treatment outcome in an alcohol dependent and depressed population. METHOD: The Treatment Evaluation of Alcohol and Mood (TEAM) study was a randomized controlled pharmacotherapy trial with supportive clinical case management...
August 2018: Journal of Substance Abuse Treatment
Colette Nickodem, Michael F Criscitiello, Fuller Bazer, Olayinka Abiodun-Ojo, Brandie D Taylor
PROBLEM: Recently characterized interferon epsilon (IFNe) protects against sexually transmitted infections, including genital herpes simplex virus (HSV), in animal models. There are no reports of IFNe in genital tract secretions of pregnant women, and data on IFNe in non-pregnant women are limited. This pilot study is the first to measure concentrations of IFNe in vaginal and cervical secretions during pregnancy and compare values between healthy and genital HSV-infected women. METHOD OF STUDY: Vaginal or cervical specimens from 30 pregnant women were obtained from the Global Alliance to Prevent Prematurity and Stillbirth (GAPPS) repository...
June 14, 2018: American Journal of Reproductive Immunology: AJRI
Eric J Bruns, Alyssa N Hook, Elizabeth M Parker, Isabella Esposito, April Sather, Ryan M Parigoris, Aaron R Lyon, Kelly L Hyde
BACKGROUND: Electronic health records (EHRs) have been widely proposed as a mechanism for improving health care quality. However, rigorous research on the impact of EHR systems on behavioral health service delivery is scant, especially for children and adolescents. OBJECTIVE: The current study evaluated the usability of an EHR developed to support the implementation of the Wraparound care coordination model for children and youth with complex behavioral health needs, and impact of the EHR on service processes, fidelity, and proximal outcomes...
June 14, 2018: Journal of Medical Internet Research
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