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Muscular hypertrophy

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https://www.readbyqxmd.com/read/29886624/-establishment-and-evaluation-of-a-new-method-for-determining-hemodynamics-of-pulmonary-hypertension-rats
#1
Q Y Zheng, M D Kuang, Y Li, X T Wu, J Y Huang, C T Zhang, H W Liu, W J Lu, J Wang, Y Q Chen
Objective: By evaluating the hemodynamic parameters such as cardiac output (CO), right ventricular pressure (RVP), pulmonary artery pressure (PAP) and total pulmonary resistance index (TPRI) in pulmonary hypertension rat model, we established a more comprehensive hemodynamic evaluation system, which objectively evaluated the severity of disease and exercise tolerance in rats with pulmonary hypertension. Methods: SD rats were randomly divided into a control group and a model group with 5 rats in each group. The model group was intraperitoneally injected with SU5416 (20 mg/kg) and placed in an oxygen chamber at a 10% oxygen concentration for 21 days and then placed in a normoxic environment for 14 days...
June 12, 2018: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/29872120/rapamycin-attenuates-pathological-hypertrophy-caused-by-an-absence-of-trabecular-formation
#2
Nicole D Fleming, Leigh A Samsa, David Hassel, Li Qian, Jiandong Liu
Cardiac trabeculae are mesh-like muscular structures within ventricular walls. Subtle perturbations in trabeculation are associated with many congenital heart diseases (CHDs), and complete failure to form trabeculae leads to embryonic lethality. Despite the severe consequence of an absence of trabecular formation, the exact function of trabeculae remains unclear. Since ErbB2 signaling plays a direct and essential role in trabecular initiation, in this study, we utilized the erbb2 zebrafish mutant as a model to address the function of trabeculae in the heart...
June 5, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29852092/high-frequency-resistance-training-does-not-promote-greater-muscular-adaptations-compared-to-low-frequencies-in-young-untrained-men
#3
Cintia Barcelos, Felipe Damas, Sanmy Rocha Nóbrega, Carlos Ugrinowitsch, Manoel Emílio Lixandrão, Lucas Marcelino Eder Dos Santos, Cleiton Augusto Libardi
The aim of the study was to compare the effect of resistance training (RT) frequencies of five times (RT5), thrice- (RT3) or twice- (RT2) weekly in muscle strength and hypertrophy in young men. Were used a within-subjects design in which 20 participants had one leg randomly assigned to RT5 and the other to RT3 or to RT2. 1 RM and muscle cross-sectional area (CSA) were assessed at baseline, after four (W4) and eight (W8) RT weeks. RT5 resulted in greater total training volume (TTV) than RT3 and RT2 (P = ...
May 31, 2018: European Journal of Sport Science
https://www.readbyqxmd.com/read/29803204/physiological-responses-to-different-neuromuscular-movement-task-during-eccentric-bench-press
#4
Michal Wilk, Petr Stastny, Artur Golas, Monika Nawrocka, Karel Jelen, Adam Zajac, James J Tufano
OBJECTIVES: Increasing muscular hypertrophy is one of the main reasons for participating in a resistance training program, where different movement task such as eccentric cadences may serve as a potent hypertrophic stimulus and improve movement stability. Aim of this study was to investigate the physiological responses between slow 6/0/2/0 (SLOW) and moderate 2/0/2/0 (REG) eccentric cadences during five sets of bench press to failure using 70% 1 repetition maximum (1RM). MATERIALS AND METHODS: Blood samples from sixteen men (21-29y, 85...
March 27, 2018: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/29792278/a-novel-endoscopic-grading-system-for-prediction-of-disease-related-outcomes-in-patients-with-diverticulosis
#5
Meara Dean, Joseph Valentino, Kaitlin Ritter, James Church
BACKGROUND: We describe a simple endoscopic grading system of diverticular disease for the assessment of disease severity and prediction of outcomes. METHODS: A retrospective analysis of prospectively maintained colonoscopy database was conducted. A single endoscopist prospectively graded disease severity according to the number and size of diverticula, the degree of muscular hypertrophy and rigidity of the sigmoid colon. RESULTS: 762 patients were included in the analysis...
May 12, 2018: American Journal of Surgery
https://www.readbyqxmd.com/read/29766442/rate-of-improvement-of-pain-and-function-in-mid-portion-achilles-tendinopathy-with-loading-protocols-a-systematic-review-and-longitudinal-meta-analysis
#6
REVIEW
Myles Murphy, Mervyn Travers, William Gibson, Paola Chivers, James Debenham, Sean Docking, Ebonie Rio
BACKGROUND: Mid-portion Achilles tendinopathy is prevalent within both the athletic and non-athletic populations and loading protocols for Achilles tendinopathy are effective over time, though the rate of symptom change throughout rehabilitation is unknown. OBJECTIVE: The objective of this study was to determine the rate of change in pain and function over time in patients while completing a loading protocol for mid-portion Achilles tendinopathy. METHODS: A systematic review and longitudinal meta-analysis was conducted as per the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines...
May 15, 2018: Sports Medicine
https://www.readbyqxmd.com/read/29761545/comparison-of-the-large-muscle-group-widths-of-the-pelvic-limb-in-seven-breeds-of-dogs
#7
Seyyid Said Sabanci, Mehmet Kamil Ocal
Orthopaedic diseases are common in the pelvic limbs of dogs, and reference values for large muscle groups of the pelvic limb may aid in diagnosis such diseases. As such, the objective of this study was to compare the large muscle groups of the pelvic limb in seven breeds of dogs. A total of 126 dogs from different breeds were included, and the widths of the quadriceps, hamstring and gastrocnemius muscles were measured from images of the lateral radiographies. The width of the quadriceps was not different between the breeds, but the widths of the hamstring and gastrocnemius muscles were significantly different between the breeds...
May 14, 2018: Anatomia, Histologia, Embryologia
https://www.readbyqxmd.com/read/29759027/upper-limb-congenital-muscular-hypertrophy-and-aberrant-muscle-syndrome-in-children
#8
Emmanuel Dahan, Camilo Chaves, Manon Bachy, Frank Fitoussi
Congenital muscle hypertrophy of the upper limb is a very rare condition with unknown aetiology. This descriptive observational and retrospective series included eight children followed by a multidisciplinary team from 2005 to 2017. The diagnosis was based on a cluster of clinical and radiological characteristics after elimination of differential diagnoses. Patients were categorized according to: anomalies of the wrist, anomalies of long fingers of intrinsic or extrinsic origin; and anomalies of the thumb with or without first web space contracture...
January 1, 2018: Journal of Hand Surgery, European Volume
https://www.readbyqxmd.com/read/29755629/interventricular-vessel-of-the-heart
#9
Pekka J Kuusela
The communication from right to left through the interventricular septum of the heart became identified by the anatomical study for 4 years. One thousand nine hundred years ago, Galen stated that blood seeps through the perforations in the interventricular septum of the heart. However, William Harvey, working 400 years ago, failed to find any. The interventricular vessel is a slit between the fibers of the muscle feasible to be patent by relaxing and widening of the helical heart at the right atrial filling phase at the end of the diastole...
April 2018: Cardiology Research
https://www.readbyqxmd.com/read/29731719/rhace2-therapy-modifies-bleomycin-induced-pulmonary-hypertension-via-rescue-of-vascular-remodeling
#10
Anandharajan Rathinasabapathy, Andrew J Bryant, Toshio Suzuki, Christy Moore, Sheila Shay, Santhi Gladson, James D West, Erica J Carrier
Background: Pulmonary hypertension (PH) is a progressive cardiovascular disease, characterized by endothelial and smooth muscle dysfunction and vascular remodeling, followed by right heart failure. Group III PH develops secondarily to chronic lung disease such as idiopathic pulmonary fibrosis (IPF), and both hastens and predicts mortality despite of all known pharmacological interventions. Thus, there is urgent need for development of newer treatment strategies. Objective: Angiotensin converting enzyme 2 (ACE2), a member of the renin angiotensin family, is therapeutically beneficial in animal models of pulmonary vascular diseases and is currently in human clinical trials for primary PH...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29722250/the-effects-of-8-weeks-of-two-different-training-methods-on-on-sight-lead-climbing-performance
#11
Marc Philippe, Ingo Filzwieser, Veronika Leichtfried, Cornelia Blank, Simon Haslinger, Johannes Fleckenstein, Wolfgang Schobersberger
BACKGROUND: Despite climbing being an increasingly popular sporting pursuit, there have been very few scientific evaluations of appropriate training methods for competitive climbers. The aim of this study was to investigate the effects of an 8-week climbing-specific muscular hypertrophy (MH) or muscular endurance (ME) resistance training program on the on-sight lead climbing performance in a similar setting to a world cup. METHODS: Twenty-three elite male and female climbers (age: 25...
May 2, 2018: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/29701412/functional-popliteal-artery-entrapment-syndrome
#12
Luis Gamas, João Rocha Neves, Luís Machado, Ricardo Ferreira, Pedro Paz Dias, José Teixeira
INTRODUCTION: Popliteal artery entrapment is an uncommon syndrome, caused by extrinsic compression of the popliteal artery by muscular or tendinous structures. It occurs mainly in young individuals, with no atherosclerostic risk factors, and a mean age of presentation of 20 to 40 years, and has higher prevalence in males (83% of patients). Clinical presentation depends on the degree of arterial lesion, the most common being intermittent claudication, with critical ischemia being frequent...
July 2017: Revista Portuguesa de Cirurgia Cardio-torácica e Vascular
https://www.readbyqxmd.com/read/29690867/identification-of-genes-directly-responding-to-dlk1-signaling-in-callipyge-sheep
#13
Hui Yu, Jolena N Waddell, Shihuan Kuang, Ross L Tellam, Noelle E Cockett, Christopher A Bidwell
BACKGROUND: In food animal agriculture, there is a need to identify the mechanisms that can improve the efficiency of muscle growth and protein accretion. Callipyge sheep provide excellent machinery since the up-regulation of DLK1 and RTL1 results in extreme postnatal muscle hypertrophy in distinct muscles. The aim of this study is to distinguish the genes that directly respond to DLK1 and RTL1 signaling from the genes that change as the result of muscle specific effects. RESULTS: The quantitative PCR results indicated that DLK1 expression was significantly increased in hypertrophied muscles but not in non-hypertrophied muscles...
April 24, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29690525/quadrilateral-space-syndrome-diagnosis-and-clinical-management
#14
REVIEW
Patrick T Hangge, Ilana Breen, Hassan Albadawi, M Grace Knuttinen, Sailendra G Naidu, Rahmi Oklu
Quadrilateral space syndrome (QSS) is a rare disorder characterized by axillary nerve and posterior humeral circumflex artery (PHCA) compression within the quadrilateral space. Impingement is most frequently due to trauma, fibrous bands, or hypertrophy of one of the muscular borders. Diagnosis can be complicated by the presence of concurrent traumatic injuries, particularly in athletes. Since many other conditions can mimic QSS, it is often a diagnosis of exclusion. Conservative treatment is often first trialed, including physical exercise modification, physical therapy, and therapeutic massage...
April 21, 2018: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/29683914/different-patterns-in-muscular-strength-and-hypertrophy-adaptations-in-untrained-individuals-undergoing-nonperiodized-and-periodized-strength-regimens
#15
Eduardo O De Souza, Valmor Tricoli, Jacob Rauch, Michael R Alvarez, Gilberto Laurentino, André Y Aihara, Fabiano N Cardoso, Hamilton Roschel, Carlos Ugrinowitsch
De Souza, EO, Tricoli, V, Rauch, J, Alvarez, MR, Laurentino, G, Aihara, AY, Cardoso, FN, Roschel, H, and Ugrinowitsch, C. Different patterns in muscular strength and hypertrophy adaptations in untrained individuals undergoing non-periodized and periodized strength regimens. J Strength Cond Res 32(5): 1238-1244, 2018-This study investigated the effects of nonperiodized (NP), traditional periodization (TP), and daily undulating periodization (UP) regimens on muscle strength and hypertrophy in untrained individuals...
May 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29658408/the-compatibility-of-concurrent-high-intensity-interval-training-and-resistance-training-for-muscular-strength-and-hypertrophy-a-systematic-review-and-meta-analysis
#16
Angelo Sabag, Abdolrahman Najafi, Scott Michael, Tuguy Esgin, Mark Halaki, Daniel Hackett
The purpose of this systematic review and meta-analysis is to assess the effect of concurrent high intensity interval training (HIIT) and resistance training (RT) on strength and hypertrophy. Five electronic databases were searched using terms related to HIIT, RT, and concurrent training. Effect size (ES), calculated as standardised differences in the means, were used to examine the effect of concurrent HIIT and RT compared to RT alone on muscle strength and hypertrophy. Sub-analyses were performed to assess region-specific strength and hypertrophy, HIIT modality (cycling versus running), and inter-modal rest responses...
April 16, 2018: Journal of Sports Sciences
https://www.readbyqxmd.com/read/29652692/potential-roles-of-vascular-endothelial-growth-factor-during-skeletal-muscle-hypertrophy
#17
Kimberly A Huey
Vascular endothelial growth factor (VEGF) deletion in adult mouse muscle fibers contributes to impaired contractile and muscular adaptations to a hypertrophic stimulus suggesting a critical role in adult muscle growth. This review will explore the hypothesis that VEGF is essential for adult muscle growth by impacting inflammatory processes, satellite-endothelial cell interactions, and contractile protein accumulation by functioning within known hypertrophic signaling pathways including insulin-like growth factor-1 (IGF-1-Akt) and Wnt-ß-catenin...
April 12, 2018: Exercise and Sport Sciences Reviews
https://www.readbyqxmd.com/read/29619802/improving-muscular-strength-and-hypertrophy-are-we-following-the-right-scientific-way
#18
Marcos D Polito
No abstract text is available yet for this article.
April 4, 2018: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/29577809/spectrum-of-neuromuscular-disorders-with-hyperckemia-from-a-tertiary-care-pediatric-neuromuscular-center
#19
Fouad Al-Ghamdi, Basil T Darras, Partha S Ghosh
Elevated creatine kinase is a useful screening test in the diagnostic workup of patients with neuromuscular disorders. We did a retrospective study of children with hyperCKemia (>175 IU/L) who were followed in the neuromuscular program of a tertiary care pediatric center from 2005 to 2016. Patients with hyperCKemia were divided into 2 groups: myopathic and nonmyopathic. Within the myopathic group, there were 3 arbitrary subgroups based on creatine kinase values: A (creatine kinase >10 times normal), B (creatine kinase 5-10 times normal), and C (creatine kinase 1-5 times normal)...
May 2018: Journal of Child Neurology
https://www.readbyqxmd.com/read/29572181/urinary-bladder-organ-hypertrophy-is-partially-regulated-by-akt1-mediated-protein-synthesis-pathway
#20
Li-Ya Qiao, Chunmei Xia, Shanwei Shen, Seong Ho Lee, Paul H Ratz, Matthew O Fraser, Amy Miner, John E Speich, Jeffrey J Lysiak, William D Steers
AIMS: The present study aims to investigate the role of Akt in the regulation of urinary bladder organ hypertrophy caused by partial bladder outlet obstruction (pBOO). MAIN METHODS: Male rats were surgically induced for pBOO. Real-time PCR and western blot were used to examine the levels of mRNA and protein. A phosphoinositide 3-kinase (PI3K) inhibitor LY294002 was used to inhibit the activity of endogenous Akt. KEY FINDINGS: The urinary bladder developed hypertrophy at 2 weeks of pBOO...
May 15, 2018: Life Sciences
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