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https://www.readbyqxmd.com/read/28645013/per-and-polyfluoroalkyl-substances-in-human-serum-and-urine-samples-from-a-residentially-exposed-community
#1
Rachel Rogers Worley, Susan McAfee Moore, Bruce C Tierney, Xiaoyun Ye, Antonia M Calafat, Sean Campbell, Million B Woudneh, Jeffrey Fisher
BACKGROUND: Per- and polyfluoroalkyl substances (PFAS) are considered chemicals of emerging concern, in part due to their environmental and biological persistence and the potential for widespread human exposure. In 2007, a PFAS manufacturer near Decatur, Alabama notified the United States Environmental Protection Agency (EPA) it had discharged PFAS into a wastewater treatment plant, resulting in environmental contamination and potential exposures to the local community. OBJECTIVES: To characterize PFAS exposure over time, the Agency for Toxic Substances and Disease Registry (ATSDR) collected blood and urine samples from local residents...
June 20, 2017: Environment International
https://www.readbyqxmd.com/read/28634796/effects-of-perfluorooctanoic-acid-and-perfluorooctane-sulfonate-on-acute-toxicity-superoxide-dismutase-and-cellulase-activity-in-the-earthworm-eisenia-fetida
#2
Zuoqing Yuan, Jianyong Zhang, Lili Zhao, Jing Li, Hongbin Liu
Perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) are the two best-known perfluorinated chemicals and have received much attention due to their ubiquity in the environment. In the present study, we evaluated the effects of PFOS and PFOA on acute toxicity, superoxide dismutase (SOD), and cellulase activities in Eisenia fetida. The results of acute toxicity testing using a filter paper contact test and a natural field soil test showed that PFOA and PFOS exhibited acute toxicity in earthworms, and the toxic effect of PFOS was greater than that of PFOA...
June 20, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28634686/respiratory-uptake-and-depuration-kinetics-of-perfluorooctanesulfonate-pfos-in-a-marine-sandworm-species
#3
Takeo Sakurai, Jun Kobayashi, Nozomi Ito, Shigeko Serizawa, Hiroaki Shiraishi, Tohru Yabe, Yuichi Ishii, Noriyuki Suzuki
We determined the respiratory uptake and depuration kinetics of perfluorooctanesulfonate (PFOS) in Perinereis wilsoni, a polychaete sandworm used as a model species to investigate the fate of chemical pollutants in coastal environments. The sandworms were kept in gravel-packed containers, and the water levels were varied cyclically to mimic the tides. We used seawater kept at 17.1°C. A 7-day exposure period was followed by a 9-day depuration period. The dissolved PFOS concentration averaged 28 ng/L during the exposure period...
June 20, 2017: Bulletin of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28634058/apoptotic-gene-expression-profiles-and-dna-damage-levels-in-rat-liver-treated-with-perfluorooctane-sulfonate-and-protective-role-of-curcumin
#4
Dilek Eke, Ayla Çelik, Mehmet Bertan Yilmaz, Nurcan Aras, Sabriye Kocatürk Sel, Davut Alptekin
Perfluorinated compounds (PFCs) such as PFOS and PFOA, are xenobiotics that can be detected worldwide in the environment and humans. PFOS (C8F17SO3(-)) is a fluorinated organic compound has been used for decades in industrial and commercial products. We investigated the genotoxic and apoptotic impact of PFOS in rat liver using comet assay, micronucleus test and apoptotic gene expression methods for caspase 3, caspase 8 and the protective role of curcumin on the PFOS- induced damage under chronic exposure. In this study, rats were treated either with three different PFOS doses only (0...
June 17, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28633112/perfluorinated-alkyl-substances-in-spanish-adults-geographical-distribution-and-determinants-of-exposure
#5
Mónica Bartolomé, Alejandrina Gallego-Picó, Francisco Cutanda, Olga Huetos, Marta Esteban, Beatriz Pérez-Gómez, Argelia Castaño
Per- and polyfluoroalkyl substances (PFAS) are widely found in humans and the environment. Their persistence, bioaccumulation and toxicity make them a source of increasing public health concern. In this study, we analyzed the concentrations and geographical distribution of six PFAS in the serum of 755 Spanish adults aged 18-65. The geometric mean concentrations (and P95 values) for PFOS (perfluoroctane sulfonate), PFOA (perfluorooctanoic acid), PFHxS (perfluorohexane sulfonate), PFNA (perfluorononanoic acid) and PFDA (perfluorodecanoic acid) were 7...
June 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28633063/serum-perfluoroalkyl-acids-pfaas-and-associations-with-behavioral-attributes
#6
Rebecca Siebenaler, Rochelle Cameron, Craig M Butt, Kate Hoffman, Christopher P Higgins, Heather M Stapleton
The ubiquitous use of poly- and perfluoroalkyl substances (PFASs) in a variety of industrial and consumer products has resulted in chronic exposure in most industrialized nations, and led to measurable concentrations in blood and other tissues in humans across all life stages; however, behavioral attributes that relate to exposure are not well studied. To further investigate how behavior may relate to PFAS exposure, 37 adults were recruited from central North Carolina. Participants provided blood samples and behavioral questionnaires were administered, asking questions about a variety of household, dietary, and behavioral outcomes...
June 9, 2017: Chemosphere
https://www.readbyqxmd.com/read/28628233/spatial-and-temporal-trends-of-poly-and-perfluoroalkyl-substances-in-fish-fillets-and-water-collected-from-pool-2-of-the-upper-mississippi-river
#7
John L Newsted, Ryan Holem, Cleston Lange, Mark Ellefson, Gary Hohenstein, William Reagen, Susan Wolf
In 2011, poly- and perfluoroalkyl substances (PFASs) were analyzed in surface water and fish fillet samples taken from Pool 2 of the Upper Mississippi River, a 33-mile stretch inclusive of the Minneapolis/St. Paul, Minnesota metropolitan area. Approximately 100 each of bluegill (BGS), freshwater drum (FWD), smallmouth bass (SMB), and white bass (WHB) were sampled within the study area. Surface water samples were also collected from each of the 10 sampling reaches established for the study. Water and fillet samples were analyzed for perfluorinated carboxylic acids (PFCAs) (C4-C12), perfluorinated sulfonic acids (PFSAs) (C4, C6, and C8), and perfluorooctane sulfonamide (FOSA)...
June 19, 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/28623747/results-of-a-national-survey-of-high-frequency-fish-consumers-in-the-united-states
#8
Katherine von Stackelberg, Miling Li, Elsie Sunderland
Exposure to contaminants in fish may be associated with adverse health outcomes even as fish consumption is generally considered beneficial. Risk assessments conducted to support regulatory analyses rely on quantitative fish consumption estimates. Here we report the results of a national survey of high-frequency fish consumers (n = 2099) based on a survey population statistically representative of ~17.6 million U.S. individuals consuming three or more fish meals per week. The survey was conducted during 2013 using an on-line survey instrument...
June 14, 2017: Environmental Research
https://www.readbyqxmd.com/read/28617200/exposure-to-pfoa-and-pfos-and-fetal-growth-a-critical-merging-of-toxicological-and-epidemiological-data
#9
Eva Negri, Francesca Metruccio, Valentina Guercio, Luca Tosti, Emilio Benfenati, Rossella Bonzi, Carlo La Vecchia, Angelo Moretto
Toxicological and epidemiological evidence on the association between perfluorooctanoic acid (PFOA) or perfluorooctane sulfonic acid (PFOS) and birth/fetal weight was assessed. An extensive search for toxicological information in rats and mice, and a systematic search for epidemiological evidence were conducted. The linear regression coefficient (LRC) of birth weight (BrthW) on PFOA/PFOS was considered, and separate random effects meta-analyses for untransformed (i.e. not mathematically transformed) and log-transformed values were performed...
July 2017: Critical Reviews in Toxicology
https://www.readbyqxmd.com/read/28614945/selective-and-fast-adsorption-of-perfluorooctane-sulfonate-from-wastewater-by-magnetic-fluorinated-vermiculite
#10
Ziwen Du, Shubo Deng, Siyu Zhang, Wei Wang, Bin Wang, Jun Huang, Yujue Wang, Gang Yu, Baoshan Xing
A novel magnetic fluorinated adsorbent with selective and fast adsorption of perfluorooctane sulfonate (PFOS) was synthesized via a simple ball milling of Fe3O4 and vermiculite loaded with a cationic fluorinated surfactant. The loaded Fe3O4 nanoparticles increased the dispersibility of fluorinated vermiculite (F-VT) in water and allowed the magnetic separability. The nano-sized Fe3O4 was homogeneously embedded into the adsorbent surfaces, improving the hydrophilicity of F-VT external surface, and this hybrid adsorbent still kept the hydrophobic fluorinated interlayer structure...
June 15, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28610584/serum-levels-of-environmental-pollutants-is-a-risk-factor-for-breast-cancer-in-inuit-a-case-control-study
#11
Maria Wielsøe, Peder Kern, Eva Cecilie Bonefeld-Jørgensen
BACKGROUND: Environmental Persistent Organic Pollutants (POPs) can alter the hormone homeostasis by mimicking, interfering or blocking the function of hormones; moreover POPs are hypothesized to modify the risk of breast cancer. The association between POPs and breast cancer has been widely studied but the conclusions are inconsistent. The present study examined the associations between serum levels of POPs and breast cancer with focus on the highly exposed Greenlandic Inuit population...
June 13, 2017: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/28599201/serum-metabolome-biomarkers-associate-low-level-environmental-perfluorinated-compound-exposure-with-oxidative-nitrosative-stress-in-humans
#12
Xiaofei Wang, Liangpo Liu, Weibing Zhang, Jie Zhang, Xiaoyan Du, Qingyu Huang, Meiping Tian, Heqing Shen
Previous in vivo and in vitro studies have linked perfluorinated compound (PFC) exposure with metabolic interruption, but the inter-species difference and high treatment doses usually make the results difficult to be extrapolated to humans directly. The best strategy for identifying the metabolic interruption may be to establish the direct correlations between monitored PFCs data and metabolic data on human samples. In this study, serum metabolome data and PFC concentrations were acquired for a Chinese adult male cohort...
June 6, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28595069/kinetic-analysis-of-aerobic-biotransformation-pathways-of-a-perfluorooctane-sulfonate-pfos-precursor-in-distinctly-different-soils
#13
Lilan Zhang, Linda S Lee, Junfeng Niu, Jinxia Liu
With the phaseout of perfluorooctane sulfonate (PFOS) production in most countries and its well known recalcitrance, there is a need to quantify the potential release of PFOS from precursors previously or currently being emitted into the environment. Aerobic biodegradation of N-ethyl perfluorooctane sulfonamidoethanol (EtFOSE) was monitored in two soils from Indiana, USA: an acidic forest silt loam (FRST-48, pH = 5.5) and a high pH agricultural loam (PSF-49, pH = 7.8) with similar organic carbon contents (2...
June 5, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28587979/diet-and-metabolic-state-are-the-main-factors-determining-concentrations-of-perfluoroalkyl-substances-in-female-polar-bears-from-svalbard
#14
Sabrina Tartu, Sophie Bourgeon, Jon Aars, Magnus Andersen, Karen Lone, Bjørn Munro Jenssen, Anuschka Polder, Gregory W Thiemann, Vidar Torget, Jeffrey M Welker, Heli Routti
Perfluoroalkyl substances (PFASs) have been detected in organisms worldwide, including Polar Regions. The polar bear (Ursus maritimus), the top predator of Arctic marine ecosystems, accumulates high concentrations of PFASs, which may be harmful to their health. The aim of this study was to investigate which factors (habitat quality, season, year, diet, metabolic state [i.e. feeding/fasting], breeding status and age) predict PFAS concentrations in female polar bears captured on Svalbard (Norway). We analysed two perfluoroalkyl sulfonates (PFSAs: PFHxS and PFOS) and C8-C13 perfluoroalkyl carboxylates (PFCAs) in 112 plasma samples obtained in April and September 2012-2013...
June 3, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28586657/the-use-of-carbon-adsorbents-for-the-removal-of-perfluoroalkyl-acids-from-potable-reuse-systems
#15
Mandu Inyang, Eric R V Dickenson
Bench- and pilot-scale sorption tests were used to probe the performance of several biochars at removing perfluoroalkyl acids (PFAA) from field waters, compared to granular activated carbon (GAC). Screening tests using organic matter-free water resulted in hardwood (HWC) (Kd = 41 L g(-1)) and pinewood (PWC) (Kd = 49 L g(-1)) biochars having the highest perfluorooctanoic acid (PFOA) removal performance that was comparable to bituminous coal GAC (Kd = 41 L g(-1)). PWC and HWC had a stronger affinity for PFOA sorbed in Lake Mead surface water (KF = 11 mg((1-n)) L(n) g(-1)) containing a lower (2 mg L(-1)) dissolved organic carbon (DOC) concentration than in a tertiary-filtered wastewater (KF = 8 mg((1-n)) L(n) g(-1)) with DOC of 4...
May 30, 2017: Chemosphere
https://www.readbyqxmd.com/read/28583010/occurrence-and-incidence-of-18-per-and-polyfluoroalkyl-compounds-in-edible-oils-commonly-consumed-in-guiyang-china
#16
Hongbo Yang, Guihong Li, Zhu Rao, Feng Guo, Zhanbin Li, Feng Xie, Hong Tan
A systematic examination was conducted for the first time of a wide carbon-chain range of per- and polyfluoroalkyl compounds (PFASs) in eighty-three samples of edible vegetable and animal oils from Guiyang, China. The occurrence and levels of 18 PFASs in 7 types of edible oil were analyzed. Analytes were determined based on a simplified, sensitive and reliable solvent extraction and liquid chromatography tandem mass spectrometry method. Ten target PFASs were found and the most frequently detected compounds with maximum concentration were PFOS (88%, 1...
June 6, 2017: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/28582977/sorption-of-poly-and-perfluoroalkyl-substances-pfass-relevant-to-aqueous-film-forming-foam-afff-impacted-groundwater-by-biochars-and-activated-carbon
#17
Xin Xiao, Bridget A Ulrich, Baoliang Chen, Christopher P Higgins
Despite growing concerns about human exposure to perfluorooctanoate (PFOA) and perfluorooctanesulfonate (PFOS), other poly- and perfluoroalkyl substances (PFASs) derived from aqueous film-forming foams (AFFFs) have garnered little attention. While these other PFASs may also be present in AFFF-impacted drinking water, their removal by conventional drinking-water treatment is poorly understood. This study compared the removal of 30 PFASs, including 13 recently discovered PFASs, from an AFFF-impacted drinking water using carbonaceous sorbents (i...
June 6, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28576466/are-additive-effects-of-dietary-surfactants-on-intestinal-tight-junction-integrity-an-overlooked-human-health-risk-a-mixture-study-on-caco-2-monolayers
#18
Anders Glynn, Annachiara Malin Igra, Salomon Sand, Nils Gunnar Ilbäck, Karl Erik Hellenäs, Johan Rosén, Bitte Aspenström-Fagerlund
Surfactants may cause dysfunction of intestinal tight junctions (TJs), which is a common feature of intestinal autoimmune diseases. Effects of dietary surfactants on TJ integrity, measured as trans-epithelial resistance (TEER), were studied in Caco-2 cell monolayers. Cytotoxicity was assessed as apical LDH leakage. Monolayers were apically exposed for 60 min to the dietary surfactants solanine and chaconine (SC, potato glycoalkaloids, 0-0.25 mM), perfluorooctane sulfonic acid (PFOS, industrial contaminant, 0-0...
May 30, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28558994/ppar%C3%AE-independent-transcriptional-targets-of-perfluoroalkyl-acids-revealed-by-transcript-profiling
#19
Mitchell B Rosen, Kaberi P Das, John Rooney, Barbara Abbott, Christopher Lau, J Christopher Corton
Perfluoroalkyl acids (PFAAs) are ubiquitous and persistent environmental contaminants. Compounds such as perfluoroocanoic acid (PFOA), perfluorooctane sulfonate (PFOS), perfluorononanoic acid (PFNA), and perfluorohexane sulfonate (PFHxS) are readily found in the tissues of humans and wildlife. While PFOA and PFOS have been the subject of numerous studies since they were first described over a decade ago, less is known about the biological activity of PFHxS and PFNA. Most PFAAs are activators of peroxisome proliferator-activated receptor α (PPARα), although the biological effects of these compounds are likely mediated by other factors in addition to PPARα...
May 27, 2017: Toxicology
https://www.readbyqxmd.com/read/28558235/tissue-uptake-distribution-and-elimination-of-perfluoroalkyl-substances-in-juvenile-perch-through-perfluorooctane-sulfonamidoethanol-based-phosphate-diester-dietary-exposure
#20
Juliette Gaillard, Bruno Veyrand, Marielle Thomas, Xavier Dauchy, Virginie Boiteux, Philippe Marchand, Bruno Le Bizec, Damien Banas, Cyril Feidt
Perfluorooctane sulfonamidoethanol based phosphate diester (SAmPAP) is a potential perfluorooctanesulfonate (PFOS) precursor. To examine whether SAmPAP exposure would result in fish contamination by perfluoroalkyl and polyfluoroalkyl substances (PFASs), juvenile Eurasian perch were dietarily exposed to this compound (dosed group) or exposed to the same tank water but fed control feed (control group). SAmPAP and metabolites were monitored in the muscle, liver, and serum during the 45-day exposure phase and 35-day depuration phase...
June 22, 2017: Environmental Science & Technology
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