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Contact dermatitis

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https://www.readbyqxmd.com/read/27914155/-main-causes-of-occupational-allergic-contact-dermatitis-a-three-year-study-in-the-center-of-portugal
#1
Catarina Pestana, Raquel Gomes, Vítor Pinheiro, Miguel Gouveia, Isabel Antunes, Margarida Gonçalo
INTRODUCTION: Allergic contact dermatitis, along with irritant contact dermatitis and immediate contact reactions, contact urticarial, are the most frequent dermatological occupational disease, but seldom reported to the National authorities. MATERIAL AND METHODS: We performed a 3-year retrospective study at the allergology section in the Dermatology Clinic of the University Hospital of Coimbra to evaluate the main occupations diagnosed as occupational allergic contact dermatitis, most common allergens and the effect of the modification of the work station in the evolution of the disease...
August 2016: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/27910751/recent-advances-in-pharmacotherapeutic-paradigm-of-mild-to-recalcitrant-atopic-dermatitis
#2
Zahid Hussain, Shariza Sahudin, Hnin Ei Thu, Ahmad Nazrun Shuid, Syed Nasir Abbas Bukhari, Endang Kumolosasi
Atopic dermatitis (AD) is a common, chronic skin inflammatory disorder characterized by perivascular infiltration of immunoglobulin E (IgE), T lymphocytes, and mast cells. The key factors responsible for the pathophysiology of this disease are immunological disorders and defects in epidermal barrier properties. Pruritus, intense itching, psychological stress, deprived physical and mental performance, and sleep disturbance are the hallmark features of this dermatological disorder. Preventive interventions such as educational programs, avoidance of allergens, and exclusive care toward the skin could play a partial role in suppressing the symptoms...
2016: Critical Reviews in Therapeutic Drug Carrier Systems
https://www.readbyqxmd.com/read/27896884/contact-allergy-to-preservatives-essca-results-with-the-baseline-series-2009-2012
#3
Ana M Giménez-Arnau, Gustavo Deza, Andrea Bauer, Graham A Johnston, Vera Mahler, Marie-Louise Schuttelaar, Javier Sanchez-Perez, Juan Francisco Silvestre, Mark Wilkinson, Wolfgang Uter
BACKGROUND: Allergic contact dermatitis caused by biocides is common, and causes significant patient morbidity. OBJECTIVE: To describe the current frequency and pattern of patch test reactivity to biocide allergens included in the baselines series of most European countries. METHODS: Data collected by the European Surveillance System on Contact Allergies (ESSCA) network between 2009 and 2012 from 12 European countries were analysed. RESULTS: Methylisothiazolinone 0...
November 29, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27889218/single-stage-urethroplasty-for-perineal-hypospadias-in-a-horse-a-case-report
#4
Jade Harrison, Imran Mushtaq
INTRODUCTION: Within the veterinary world, data regarding the surgical management of hypospadias is lacking. Reports within equines have documented resective phallectomy procedures rather than urethral reconstruction. This case report documents the first ever urethroplasty for an equine hypospadias, performed by a consultant paediatric surgeon. The urethroplasty was achieved by applying the same surgical principles mastered from paediatric urology to a horse. The indication for surgery was contact dermatitis of the hind-leg, which impaired the thoroughbred foal's racing potential...
November 9, 2016: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/27886908/cutaneous-manifestation-of-food-allergy
#5
REVIEW
Jonathan S Tam
Hypersensitivity reactions to foods can have diverse and highly variable manifestations. Cutaneous reactions, such as acute urticaria and angioedema, are among the most common manifestations of food allergy. However, cutaneous manifestations of food allergy encompass more than just IgE-mediated processes and include atopic dermatitis, contact dermatitis, and even dermatitis herpetiformis. These cutaneous manifestations provide an opportunity to better understand the diversity of adverse immunologic responses to food and the interconnected pathways that produce them...
February 2017: Immunology and Allergy Clinics of North America
https://www.readbyqxmd.com/read/27886903/allergic-contact-dermatitis
#6
REVIEW
Lisa Kostner, Florian Anzengruber, Caroline Guillod, Mike Recher, Peter Schmid-Grendelmeier, Alexander A Navarini
Allergic contact dermatitis (ACD) is a common skin disease caused by a T cell-mediated immune reaction to usually innocuous allergens. ACD can have grave medical and socioeconomic consequences. ACD and irritant contact dermatitis often occur together. A detailed history and clinical examination are crucial and guide patch testing, which is the gold standard to diagnose ACD. T-cell clones persisting in the skin may explain the tendency of ACD to relapse even after years of allergen avoidance. Traditional treatments for ACD are topical steroids, calcineurin inhibitors, phototherapy, retinoids (including the recent alitretinoin), and immunosuppressants...
February 2017: Immunology and Allergy Clinics of North America
https://www.readbyqxmd.com/read/27882588/clinical-and-epidemiological-analysis-in-149-cases-of-rhododendrol-induced-leukoderma
#7
Momoko Yoshikawa, Yasuyuki Sumikawa, Tokimasa Hida, Takafumi Kamiya, Kimi Kase, Yasue Ishii-Osai, Junji Kato, Yuji Kan, Shiori Kamiya, Yuki Sato, Toshiharu Yamashita
Rhododendrol-induced leukoderma is an acquired depigmentation that develops mainly at the contact site after repeated use of skin-whitening cosmetics containing rhododendrol. In most cases, cessation of further depigmentation or occurrence of repigmentation is observed after discontinuing the use of cosmetics. However, some patients develop vitiligo vulgaris through the spread of depigmentation into the non-exposed areas. Our study aims to investigate the patient-specific factors that may affect the extent of depigmentation or repigmentation, as well as development of vitiligo vulgaris...
November 24, 2016: Journal of Dermatology
https://www.readbyqxmd.com/read/27882527/diclofenac-induced-allergic-contact-dermatitis-a-series-of-four-patients
#8
Sandra Jerkovic Gulin, Anca Chiriac
Allergic contact dermatitis is an immune-mediated antigen-specific skin reaction to an allergenic chemical that corresponds to a delayed-type hypersensitivity response (type IV reaction). Allergic contact dermatitis should be suspected when skin lesions are localized to the site of previous applications of the culprit drug. Lesions appear after re-exposure in susceptible persons, with delayed onset (more than 24 h after exposure). The gold standard for diagnosis is patch (epicutaneous) testing; identification and removal of any potential causal agents is crucial...
December 2016: Drug Safety—Case Reports
https://www.readbyqxmd.com/read/27881823/nanobodies-that-block-gating-of-the-p2x7-ion-channel-ameliorate-inflammation
#9
Welbeck Danquah, Catherine Meyer-Schwesinger, Björn Rissiek, Carolina Pinto, Arnau Serracant-Prat, Miriam Amadi, Domenica Iacenda, Jan-Hendrik Knop, Anna Hammel, Philine Bergmann, Nicole Schwarz, Joana Assunção, Wendy Rotthier, Friedrich Haag, Eva Tolosa, Peter Bannas, Eric Boué-Grabot, Tim Magnus, Toon Laeremans, Catelijne Stortelers, Friedrich Koch-Nolte
Ion channels are desirable therapeutic targets, yet ion channel-directed drugs with high selectivity and few side effects are still needed. Unlike small-molecule inhibitors, antibodies are highly selective for target antigens but mostly fail to antagonize ion channel functions. Nanobodies-small, single-domain antibody fragments-may overcome these problems. P2X7 is a ligand-gated ion channel that, upon sensing adenosine 5'-triphosphate released by damaged cells, initiates a proinflammatory signaling cascade, including release of cytokines, such as interleukin-1β (IL-1β)...
November 23, 2016: Science Translational Medicine
https://www.readbyqxmd.com/read/27879459/clinical-and-epidemiological-features-of-paederus-dermatitis-among-nut-farm-workers-in-turkey
#10
Emel Uzunoğlu, Işıl Deniz Oğuz, Büşra Kır, Cihangir Akdemir
Paederus dermatitis is an acute irritant dermatitis resulting from contact with the hemolymph of Paederus beetles. This dermatitis mimics other infectious skin disorders, often resulting in diagnostic dilemmas. This study of 46 patients was conducted to increase awareness about Paederus dermatitis. Possible causes of a number of cases of Paederus dermatitis in Giresun, Turkey, were investigated using climate data and telephone interviews with the patients about risk factors. Insects caught by patients were identified at the species level...
November 22, 2016: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/27879074/s1-guidelines-on-the-diagnosis-and-treatment-of-scabies-short-version
#11
Cord Sunderkötter, Hermann Feldmeier, Regina Fölster-Holst, Bertram Geisel, Sabine Klinke-Rehbein, Alexander Nast, Sandra Philipp, Bernhardt Sachs, Julia Stingl, Johanna Stoevesandt, Henning Hamm
The goals of this German guideline are the improvement of diagnosis and therapy of scabies, the implementation of a coordinated action in outbreaks of scabies, and the control of this infestation in large migration or refugee flows.Sarcoptes scabiei var. hominis is transmitted by direct skin-to-skin contact of sufficient duration. The infectivity of female mites when removed from patients does not exceed 48 hours at room temperature (21°C) and relative humidity of 40-80%. The risk of infection rises proportionally to the number of mites on the skin and is particularly high in crusted scabies...
November 2016: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/27879026/ionizing-radiation-promotes-ccl27-secretion-from-keratinocytes-through-the-cross-talk-between-tnf-%C3%AE-and-ros
#12
Qian Zhang, Linlin Zhu, Gang Wang, Ye Zhao, Na Xiong, Hegang Bao, Wensen Jin
The skin-associated chemokine CCL27 and its receptor CCR10 mediate the immune response of skin-homing T cells. The CCL27 secreted from keratinocytes was reportedly involved in inflammatory skin diseases such as atopic dermatitis, contact dermatitis, and psoriasis. However, whether ionizing radiation increases the levels of CCL27 secretion still remains unclear. In HaCaT cells, a human keratinocyte cell line, CCL27 secretion was markedly increased after X-ray irradiation. We further found that irradiation boosted the generation of reactive oxygen species (ROS), which was concomitant with the release of tumor necrosis factor-alpha (TNF-α)...
November 23, 2016: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/27871981/oral-exposure-to-diisodecyl-phthalate-aggravates-allergic-dermatitis-by-oxidative-stress-and-enhancement-of-thymic-stromal-lymphopoietin
#13
Shiping Shen, Jinquan Li, Huihui You, Zhuo Wu, Yang Wu, Yun Zhao, Yuqing Zhu, Qing Guo, Xiaoxiao Li, Rui Li, Ping Ma, Xu Yang, Mingqing Chen
Diisodecyl phthalate (DIDP) is extensively used as an environmentally friendly plasticizer. However, little is known about the adverse effects and the underlying mechanisms of DIDP exposure on immunological diseases. We aimed to determine the role and mechanisms of DIDP exposure in allergic contact dermatitis-like skin lesions. We show that oral DIDP exposure can aggravate allergic dermatitis in mice. Moreover, an increase of ROS, total serum IgE and IL-4 levels were concomitant with this deterioration. We detected the expression of Thymic stromal lymphopoietin (TSLP) and the activation of STATs and NF-κB signal pathways...
November 18, 2016: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/27870101/airborne-contact-dermatitis-caused-by-the-sarcotesta-of-ginkgo-biloba
#14
Jiang Ji, Yujie Ding, Ge Qian
No abstract text is available yet for this article.
December 2016: Contact Dermatitis
https://www.readbyqxmd.com/read/27870099/angioedema-like-airborne-contact-dermatitis-caused-by-dittrichia-viscosa-l-greuter-in-a-hunter
#15
Caterina Foti, Paolo Romita, Giovanni Zanframundo, Viviana Cavallaro
No abstract text is available yet for this article.
December 2016: Contact Dermatitis
https://www.readbyqxmd.com/read/27870098/allergic-contact-dermatitis-caused-by-argan-oil-neem-oil-and-mimosa-tenuiflora
#16
Maria M Lauriola, Monica Corazza
No abstract text is available yet for this article.
December 2016: Contact Dermatitis
https://www.readbyqxmd.com/read/27870096/allergic-contact-dermatitis-of-the-face-caused-by-magnolia-officinalis-bark-extract
#17
Trine D Nilausen, Jeanne D Johansen, Jacob P Thyssen
No abstract text is available yet for this article.
December 2016: Contact Dermatitis
https://www.readbyqxmd.com/read/27863430/diisononyl-phthalate-aggravates-allergic-dermatitis-by-activation-of-nf-kb
#18
Jun Kang, Jing Song, Shiping Shen, Baizhan Li, Xu Yang, Mingqing Chen
Several epidemiological studies have suggested a possible link between exposure to Diisononyl phthalate (DINP) and the development of allergies. These findings remain controversial since there is insufficient scientific evidence to assess the ability of DINP to influence allergic immune responses. In addition, the mechanisms behind DINP-caused allergic diseases have not been fully elucidated. In this study, Balb/c mice were orally exposed to DINP for 3 weeks and were then sensitized with fluorescein isothiocyanate (FITC)...
November 16, 2016: Oncotarget
https://www.readbyqxmd.com/read/27861990/contact-sensitization-in-dutch-children-and-adolescents-with-and-without-atopic-dermatitis%C3%A2-%C3%A2-a-retrospective-analysis
#19
Stefanie Lubbes, Thomas Rustemeyer, Johannes H Sillevis Smitt, Marie-Louise A Schuttelaar, Maritza A Middelkamp-Hup
BACKGROUND: Allergic contact dermatitis is known to occur in children with and without atopic dermatitis, but more data are needed on contact sensitization profiles in these two groups. OBJECTIVES: To identify frequent allergens in children with and without atopic dermatitis suspected of having allergic contact dermatitis. METHODS: A retrospective analysis of children aged 0-17 years patch tested between 1996 and 2013 was performed. RESULTS: Of all 1012 children tested because of suspected contact dermatitis, 46% developed one or more positive reactions, the proportions for children with (n = 526) and without (n = 395) atopic dermatitis being 48% and 47%, respectively...
November 11, 2016: Contact Dermatitis
https://www.readbyqxmd.com/read/27861735/trends-in-contact-allergy-to-fragrance-mix-i-in-consecutive-danish-eczema-patients-over-three-decades-a-cross-sectional-study-from-1986-to-2015
#20
N H Bennike, C Zachariae, J Duus Johansen
BACKGROUND: For more than 30 years, fragrance mix I (FMI) has been the most important screening marker for fragrance contact allergy. Meanwhile, governmental and corporate initiatives have been implemented, aimed at reducing sensitization to fragrance allergens, including the single constituents of FMI. OBJECTIVES: To examine trends in contact allergy to FMI from 1986 to 2015 in dermatitis patients, and test the hypothesis that sensitization to the fragrance screening marker has decreased within recent years...
November 18, 2016: British Journal of Dermatology
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