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Contact dermatitis

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https://www.readbyqxmd.com/read/29453524/a-nonsteroidal-novel-formulation-targeting-inflammatory-and-pruritus-related-mediators-modulates-experimental-allergic-contact-dermatitis
#1
William C Gordon, Virginia García López, Surjyadipta Bhattacharjee, David Rodríguez Gil, Javier Alcover Díaz, Fernando Pineda de la Losa, Ricardo Palacios Peláez, Concha Tiana Ferrer, Gabriela Silvina Bacchini, Bokkyoo Jun, Hélène Varoqui, Nicolas G Bazan
INTRODUCTION: A major clinical challenge in treating allergic contact dermatitis (ACD) is that the first line of treatment is based on the use of corticosteroids. In this study, we aimed to develop a formulation that is devoid of steroids. METHODS: We used mouse ears treated with dinitrofluorobenzene (DNFB) to induce ACD. The efficacy of the test formulation to ameliorate and to prevent induced ACD was determined. RESULTS: To treat this experimentally induced ACD, we developed a formulation containing BIPxine (a mixture of Rosa moschata and Croton lechleri (antioxidants) and Aloe vera and D-panthenol (moisturizers), and hydroglycolic solutions of disodium cromoglycate...
February 16, 2018: Dermatology and Therapy
https://www.readbyqxmd.com/read/29446120/a-novel-case-of-a-brush-with-discomfort-allergic-contact-dermatitis-caused-by-mercaptobenzothiazole-in-rubber-components-of-a-toothbrush
#2
Emily Forward, Victoria Harris, Saxon D Smith
No abstract text is available yet for this article.
February 15, 2018: Contact Dermatitis
https://www.readbyqxmd.com/read/29440874/clinical-potential-of-mechlorethamine-gel-for-the-topical-treatment-of-mycosis-fungoides-type-cutaneous-t-cell-lymphoma-a-review-on-current-efficacy-and-safety-data
#3
REVIEW
Kendall Liner, Celeste Brown, Laura Y McGirt
Nitrogen mustard is a chemotherapeutic agent that has a well-documented safety and efficacy profile in the treatment of cutaneous T-cell lymphoma. Development of nitrogen mustard formulations and treatment regimens has been studied extensively over the last 40 years. In the last 5 years, a new gel formulation has been developed that is associated with a decrease in delayed hypersensitivity reactions. The authors in this review found that while the gel formulation may result in a decrease of allergic contact dermatitis, this advantage has been replaced by a higher number of irritant contact reactions and a decrease in complete response rate...
2018: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29430710/possible-role-of-regional-variation-in-allergic-contact-dermatitis-case-report
#4
Austin Jiang, Joel C Harrison, Paul D Siegel, Howard Maibach
No abstract text is available yet for this article.
March 2018: Contact Dermatitis
https://www.readbyqxmd.com/read/29430708/allergic-contact-dermatitis-caused-by-topical-ketoconazole-a-relevant-issue-review-of-ketoconazole-positive-patch-tests
#5
Rosana Lazzarini, Mariana F S Hafner, Barbara A F Miguel, Nathalia T Kawakami, Beatriz H Y Nakagome
No abstract text is available yet for this article.
March 2018: Contact Dermatitis
https://www.readbyqxmd.com/read/29430707/lymphomatoid-contact-dermatitis-caused-by-limonene-hydroperoxides-confirmed-by-an-exposure-provocation-test-with-the-involved-personal-hygiene-products
#6
María-Elena Gatica-Ortega, María-Antonia Pastor-Nieto, Cristina Schoendorff-Ortega, Manuela Mollejo-Villanueva, Ana Giménez-Arnau
No abstract text is available yet for this article.
March 2018: Contact Dermatitis
https://www.readbyqxmd.com/read/29430705/allergic-contact-dermatitis-resulting-from-cetyl-peg-ppg-10-1-dimethicone-in-a-deodorant-cream
#7
María-Antonia Pastor-Nieto, María-Elena Gatica-Ortega, Francisco-De-Asís Alcántara-Nicolás, Raquel Pérez-Mesonero, Rocío Gil-Redondo, Eva Martín-Alcalde, Esther De Eusebio
No abstract text is available yet for this article.
March 2018: Contact Dermatitis
https://www.readbyqxmd.com/read/29429768/are-senna-based-laxatives-safe-when-used-as-long-term-treatment-for-constipation-in-children
#8
Alejandra Vilanova-Sanchez, Alessandra C Gasior, Nicole Toocheck, Laura Weaver, Richard J Wood, Carlos A Reck, Andrea Wagner, Erin Hoover, Renae Gagnon, Jordon Jaggers, Tassiana Maloof, Onnalisa Nash, Charae Williams, Marc A Levitt
BACKGROUND AND AIM: Senna is a stimulant laxative commonly used by pediatricians, pediatric gastroenterologists, and pediatric surgeons. Many clinicians avoid Senna for reasons such as tolerance or side effects but this has little scientific justification. We recently found several patients we were caring for developed perineal blistering during the course of Senna treatment. Because of this we chose to review the literature to identify side effects in children taking this medication as well as to analyze our Center's experience with Senna's secondary effects...
January 31, 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29427464/the-expression-and-function-of-galectins-in-skin-physiology-and-pathology
#9
REVIEW
Nan-Lin Wu, Fu-Tong Liu
The galectin family comprises β-galactoside-binding proteins widely expressed in many organisms. There are at least 16 family members, which can be classified into three groups based on their carbohydrate-recognition domains. Pleiotropic functions of different galectins in physiological and pathological processes through extracellular or intracellular actions have been revealed. In the skin, galectins are expressed in a variety of cells, including keratinocytes, melanocytes, fibroblasts, dendritic cells, lymphocytes, macrophages, and endothelial cells...
February 10, 2018: Experimental Dermatology
https://www.readbyqxmd.com/read/29423962/systemic-allergic-contact-dermatitis-associated-with-topical-diltiazem-and-or-cinchocaine
#10
Luis Santiago, Ana Luísa Moura, Inês Coutinho, Margarida Gonçalo
Topical anesthetics for the treatment of anal fissures or hemorrhoids are a frequent cause of allergic contact dermatitis (ACD) in the perianal region1 . Since 2009, a few cases have been reported also to the calcium channel blocker diltiazem2,3,4 used as a first-line agent in the treatment of anal fissures. We present a case of ACD from diltiazem and/or cinchocaine followed by systemic contact dermatitis (SCD). This article is protected by copyright. All rights reserved.
February 8, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29417135/efficacy-and-safety-of-guselkumab-an-anti-interleukin-23-monoclonal-antibody-for-palmoplantar-pustulosis-a-randomized-clinical-trial
#11
Tadashi Terui, Satomi Kobayashi, Yukari Okubo, Masamoto Murakami, Keiichiro Hirose, Hiroshi Kubo
Importance: Palmoplantar pustulosis (PPP) is a recalcitrant skin disease with no biologics currently approved for treatment. The involvement of interleukin 23 (IL-23) and cytokines of the type 17 helper T cell lineage in the pathogenesis of PPP has been recently postulated. Objective: To evaluate the efficacy and safety of guselkumab, an anti-IL-23 monoclonal antibody, in Japanese patients with PPP. Design, Setting, and Participants: This double-blind, randomized, placebo-controlled, parallel-group, 24-week trial was conducted between May 14, 2013, and September 27, 2014, at 11 centers in Japan...
February 7, 2018: JAMA Dermatology
https://www.readbyqxmd.com/read/29416104/signs-of-atopic-dermatitis-and-contact-dermatitis-affected-by-distinct-h2-haplotype-in-the-nc-nga-genetic-background
#12
Kozo Ohkusu-Tsukada, Daiki Ito, Yuki Okuno, Teruyo Tsukada, Kimimasa Takahashi
We recently advocated in favour of naming a novel H2-haplotype consisting of Kd, D/Ldm7, I-Ak and I-Ek in the atopic dermatitis (AD) mouse model NC/Nga as "H-2nc." The role of the H2-haplotype in AD development was investigated in H2 b -congenic NC/Nga mice (NC.h2 b/b and NC.h2 b/nc ) established by backcrossing. A severe 2,4-dinitrofluorobenzene (DNFB)-induced dermatitis in NC/Nga was alleviated partially in NC.h2 b/nc and significantly in NC.h2 b/b . The AD phenotype was correlated with thymic stromal lymphopoietin (TSLP)-epidermal expression levels and serum levels of total IgE and IL-18/IL-33...
February 7, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29404871/involvement-of-the-negative-feedback-of-il-33-signaling-in-the-anti-inflammatory-effect-of-electro-acupuncture-on-allergic-contact-dermatitis-via-targeting-microrna-155-in-mast-cells
#13
Zhigang Wang, Tao Yi, Man Long, Fengmin Ding, Lichen Ouyang, Zebin Chen
In this study, we aimed to investigate the effect of electro-acupuncture (EA) at the Zusanli acupoint (ST36) on interleukin (IL)-33-mediated mast cell activation. Firstly, 2,4-dinitrofluorobenzene (DNFB)-induced allergic contact dermatitis (ACD) in rats was developed with or without EA treatment. Then, rat peritoneal mast cells (RPMCs) were obtained and cultured in the presence of IL-33. EA treatment relieved ear swelling and reduced mast cell infiltration in the local inflammation area with DNFB challenge, accompanying the decrement of IL-33 production...
February 5, 2018: Inflammation
https://www.readbyqxmd.com/read/29399813/textile-contact-dermatitis-caused-by-octylisothiazolinone-in-compression-stockings
#14
Nils Hamnerius, Ann Pontén, Martin Mowitz
No abstract text is available yet for this article.
February 5, 2018: Contact Dermatitis
https://www.readbyqxmd.com/read/29399806/occupational-allergic-contact-dermatitis-caused-by-antibiotics-in-healthcare-workers%C3%A2-%C3%A2-relationship-with-non-immediate-drug-eruptions
#15
Vítor Pinheiro, Catarina Pestana, André Pinho, Isabel Antunes, Margarida Gonçalo
BACKGROUND: Occupational allergic contact dermatitis (ACD) in healthcare workers (HCWs) is common, but systemic antibiotics are rarely reported as the cause. OBJECTIVES: Characterize occupational ACD by handling systemic antibiotics. METHOD: A retrospective analysis was performed of ACD caused by systemic antibiotics among HCWs patch tested between 2010 and 2016 with a series of systemic antibiotics. RESULTS: We studied 4 female nurses aged 28-47 years who developed ACD while working in surgical departments...
February 5, 2018: Contact Dermatitis
https://www.readbyqxmd.com/read/29397373/the-journal-of-allergy-and-clinical-immunology-in%C3%A2-practice-2017-year-in-review
#16
REVIEW
Michael Schatz, Scott H Sicherer, Robert S Zeiger
An impressive number of clinically impactful studies and reviews were published in The Journal of Allergy and Clinical Immunology: In Practice in 2017. As a service to our readers, the editors provide this Year in Review article to highlight and contextualize the advances published over the past year. We include information from articles on asthma, allergic rhinitis, rhinosinusitis, immunotherapy, atopic dermatitis, contact dermatitis, food allergy, anaphylaxis, drug hypersensitivity, urticarial/angioedema, eosinophilic disorders, and immunodeficiency...
January 31, 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29393081/kumkum-induced-allergic-contact-dermatitis-are-we-missing-the-actual-culprit
#17
Ashwini Annabathula, S Priya, C R Srinivas
BACKGROUND: Kumkum, made with turmeric and slaked lime along with colour enhancing dyes is known to cause allergic contact dermatitis. The possible contact allergens in kumkum include turmeric, Sudan-1, 4-aminoazobenzene, brilliant lake red R and cananga oil. We report patch test results among patients with suspected contact hypersensitivity to kumkum. OBJECTIVE: To identify the allergen causing kumkum induced allergic contact dermatitis by patch testing and to advise patients about organic kumkum which doesnot contain colour enhancing dyes...
February 2, 2018: Indian Journal of Dermatology, Venereology and Leprology
https://www.readbyqxmd.com/read/29392782/allergic-contact-dermatitis-caused-by-triethylenetetramine-the-glue-is-the-clue
#18
Martina Lambertini, Colombina Vincenzi, Sandra Lorenzi, Bianca M Piraccini, Michelangelo La Placa
No abstract text is available yet for this article.
February 2, 2018: Contact Dermatitis
https://www.readbyqxmd.com/read/29392411/investigating-the-roles-of-regulatory-t-cells-mast-cells-and-interleukin-9-in-the-control-of-skin-inflammation-by-vitamin-d
#19
Shelley Gorman, Sian Geldenhuys, Clare E Weeden, Michele A Grimbaldeston, Prue H Hart
Topical application of biologically active vitamin D [1,25-dihydroxyvitamin D (1,25(OH)2D)], or low-calcemic analogues, curb skin inflammation through mechanisms that involve migratory dendritic cells (DCs) and regulatory T (TReg) cells. 1,25(OH)2D also promotes immunoregulation by mast cells, and inhibits the development of T helper type-9 (Th9) cells that secrete interleukin-9 (IL-9). Here, we investigated the ability of topical 1,25(OH)2D to suppress contact dermatitis through an IL-9-dependent process, examining mast cells and IL-9-secreting T cells...
February 1, 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/29390311/systemic-contact-dermatitis-due-to-corrosion-of-titanium-coated-nickel-and-cobalt-bone-plate-fixation-a-case-report
#20
Oki Suwarsa, Rachel Marsella Rahardjo, Endang Sutedja, Hartati Purbo Dharmadji, Reti Hindritiani, Hendra Gunawan
RATIONALE: Corrosion refers to the degradation of a material that occurs following its interaction with other substances in the environment. Corrosion of metallic substances into tissues may lead to inflammatory responses such as systemic contact dermatitis (SCD), a skin condition where an individual who has previously been sensitized to a particular allergen via the cutaneous route will subsequently react to same allergen via the systemic route. This condition occurs following exposure to allergens such as metals, medications, and certain food substances...
December 2017: Medicine (Baltimore)
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