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https://www.readbyqxmd.com/read/28203266/occupational-contact-dermatitis-from-protein-in-sea-products-who-is-the-most-affected-the-fisherman-or-the-chef
#1
B Loddé, P Cros, A M Roguedas-Contios, R Pougnet, D Lucas, J D Dewitte, L Misery
BACKGROUND: Protein contact dermatitis has frequently been reported in case studies (usually in cases involving contact with seafood products), but there are very few descriptive series. The objectives of this present study were firstly to determine the incidence of protein contact dermatitis among fishermen in France and compare it with data from onshore work involving seafood exposure. Second, to discover what factors could explain any differences. In order to answer these questions we analysed data from the French national occupational disease surveillance and prevention network (RNV3P) and occupational diseases declared to the French National Network for Monitoring and Prevention of Occupational Disease...
2017: Journal of Occupational Medicine and Toxicology
https://www.readbyqxmd.com/read/28196316/common-skin-conditions-in-children-neonatal-skin-lesions
#2
Brian Z Rayala, Dean S Morrell
Skin findings during the initial month of life are ubiquitous. One study estimated that more than 95% of newborns have cutaneous findings, which often are distressing to parents but frequently are benign and self-limited. Among them are milia, cutis marmorata, congenital dermal melanocytosis, and the benign neonatal pustular eruptions (eg, benign cephalic pustulosis, erythema toxicum neonatorum, transient neonatal pustular melanosis). Clinicians need to recognize these benign skin conditions and differentiate them from more serious conditions, such as infectious pustular eruptions from bacterial, viral, and fungal causes, and inflammatory conditions, such as Langerhans cell histiocytosis...
February 2017: FP Essentials
https://www.readbyqxmd.com/read/28194803/the-current-spectrum-of-contact-sensitization-in-patients-with-chronic-leg-ulcers-or-stasis-dermatitis%C3%A2-%C3%A2-new-data-from-the-information-network-of-departments-of-dermatology-ivdk
#3
Cornelia Erfurt-Berge, Johannes Geier, Vera Mahler
BACKGROUND: Patients with lower leg dermatitis, chronic venous insufficiency or chronic leg ulcers have a high prevalence of contact sensitization. OBJECTIVES: To identify the current spectrum of contact allergens in these patients. PATIENTS AND METHODS: Data of the Information Network of Departments of Dermatology on 5264 patients with the above diagnoses from the years 2003 to 2014 (study group) were compared with data on 4881 corresponding patients from 1994 to 2003 (historical control group) and with a current control group without these diagnoses (n = 55 510)...
February 14, 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/28174143/contact-allergy-caused-by-isothiazolinone-derivatives-an-overview-of-non-cosmetic-and-unusual-cosmetic-sources
#4
Olivier Aerts, An Goossens, Julien Lambert, Jean-Pierre Lepoittevin
The isothiazolinone derivatives, methylchloroisothiazolinone (MCI), methylisothiazolinone (MI), benzisothiazolinone (BIT), and octylisothiazolinone (OIT), owing to their strong bactericide, fungicide and algicide properties, are widely used in non-cosmetic products, such as chemical (industrial) products, household detergents, and water-based paints, and the former two derivatives are also used in cosmetic products. However, given their inherent sensitization potential (with MCI > MI > BIT > OIT), allergic contact dermatitis is frequently observed, both in consumers as well as workers in various industries...
February 3, 2017: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/28169852/gallate-contact-dermatitis-systematic-review-and-product-update
#5
Zachary E Holcomb, Megan G Van Noord, Amber Reck Atwater
Allergic contact dermatitis related to cosmetic use can result from allergens not routinely evaluated by standard patch test protocols. Propyl, octyl, and dodecyl gallates are commonly used as antioxidant preservatives with reports of associated allergic contact dermatitis in the literature. The objectives of this review were to investigate the role of gallates in allergic contact dermatitis and to explore products containing these preservatives. A systematic review of the literature through April 2016 was performed to explore cases of reported gallate allergy...
February 6, 2017: Dermatitis
https://www.readbyqxmd.com/read/28169851/periorbital-allergic-contact-dermatitis-due-to-ketotifen
#6
Kelly A Aschenbeck, Erin M Warshaw
No abstract text is available yet for this article.
February 6, 2017: Dermatitis
https://www.readbyqxmd.com/read/28169850/american-contact-dermatitis-society-core-allergen-series-2017-update
#7
Peter C Schalock, Cory A Dunnick, Susan Nedorost, Bruce Brod, Erin Warshaw, Christen Mowad
The American Contact Dermatitis Society Core Allergen Series was introduced in 2012. After 4 years of use, changes in our recommended allergens are necessary. For the updated series, we have reordered the first 4 panels to approximately mirror the current TRUE Test and removed parthenolide, triclosan, glutaraldehyde, and jasmine. Polymyxin B, lavender, sodium benzoate, ethylhexylglycerin, and benzoic acid are new additions to the American Contact Dermatitis Society series.
February 6, 2017: Dermatitis
https://www.readbyqxmd.com/read/28169849/utility-of-store-and-forward-teledermatology-for-skin-patch-test-readings
#8
Katherine R Grey, Solveig L Hagen, Sara A Hylwa, Erin M Warshaw
BACKGROUND: Teledermatology (TD) is the use of imaging technology to provide dermatology services at a distance. To date, studies assessing its application for grading skin patch test reactions have been lacking. OBJECTIVES: The aim was to compare conventional, in-person (IP) grading of skin patch test reactions with store-forward TD. METHODS: Patients undergoing patch testing to the North American Contact Dermatitis Group (NACDG) screening series were invited to participate in this repeated-measures study...
February 6, 2017: Dermatitis
https://www.readbyqxmd.com/read/28168422/contact-allergy-to-preservatives-in-patients-with-occupational-contact-dermatitis-and-exposure-analysis-of-preservatives-in-registered-chemical-products-for-occupational-use
#9
Jakob Ferløv Schwensen, Ulrik Fischer Friis, Torkil Menné, Mari-Ann Flyvholm, Jeanne Duus Johansen
PURPOSE: The aim of the study is to investigate risk factors for sensitization to preservatives and to examine to which extent different preservatives are registered in chemical products for occupational use in Denmark. METHODS: A retrospective epidemiological observational analysis of data from a university hospital was conducted. All patients had occupational contact dermatitis and were consecutively patch tested with 11 preservatives from the European baseline series and extended patch test series during a 5-year period: 2009-2013...
February 6, 2017: International Archives of Occupational and Environmental Health
https://www.readbyqxmd.com/read/28167257/tetradecanol-reduces-el-4-t-cell-growth-by-the-down-regulation-of-nf-%C3%AE%C2%BAb-mediated-il-2-secretion
#10
Jung Up Park, Bok Yun Kang, Hwa-Jeong Lee, Sunoh Kim, Donghyuck Bae, Jong-Hwan Park, Young Ran Kim
Tetradecanol is a straight-chain saturated fatty alcohol purified from Dendropanax morbifera leaves. We found that tetradecanol (30μM) reduced specifically the growth of T cells such as EL-4 T cell and isolated murine CD4(+) T cells. In this study, we investigated the effects of tetradecanol on the regulation of interlukin-2 (IL-2), a potent T cell growth factor. Tetradecanol significantly inhibited IL-2 secretion in EL-4 T cells activated with phorbol 12-myristate 13-acetate (PMA) plus ionomycin (Io) and also in isolated murine CD4(+) T cells activated with anti-CD3 and anti-CD28 antibodies...
February 3, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28157439/dermatoses-among-automobile-mechanics-in-mansoura-egypt
#11
Hala Samir Abou-ElWafa, Ahmed A Albadry, Abdel-Hady El-Gilany, Ahmed Fawzi Ismael
This cross-sectional study was carried out in Mansoura city, Egypt to assess the prevalence of occupational dermatoses and their possible risk factors on a convenience sample of car mechanics. Socio-demographic and occupational data were collected, and clinical examination was done. Prevalence of skin diseases was 45.4% and that of exclusively occupational skin diseases was 9.2%. Irritant contact dermatitis, eczema, and tar/oil acne were the commonest types (4.6%, 3.1%, 3.1%; respectively). The logistic regression analysis revealed that the risk of occupational dermatoses increased significantly with lack of use of personal protective equipment, longer duration of work, and presence of workplace chemicals [Adjusted Odds Ratio (95% CI) were 7...
February 3, 2017: Archives of Environmental & Occupational Health
https://www.readbyqxmd.com/read/28157173/contact%C3%A2-dermatitis%C3%A2-due%C3%A2-to%C3%A2-nickel%C3%A2-allergy%C3%A2-in%C3%A2-patients-suffering%C3%A2-from%C3%A2-non-celiac%C3%A2-wheat%C3%A2-sensitivity
#12
Alberto D'Alcamo, Pasquale Mansueto, Maurizio Soresi, Rosario Iacobucci, Francesco La Blasca, Girolamo Geraci, Francesca Cavataio, Francesca Fayer, Andrea Arini, Laura Di Stefano, Giuseppe Iacono, Liana Bosco, Antonio Carroccio
BACKGROUND:  Non-celiac wheat sensitivity (NCWS) is a new clinical entity in the world of  gluten-related diseases. Nickel, the most frequent cause of contact allergy, can be found in wheat  and results in systemic nickel allergy syndrome and mimics irritable bowel syndrome (IBS).  Objective: To evaluate the frequency of contact dermatitis due to nickel allergy in NCWS patients  diagnosed by a double-blind placebo-controlled(DBPC)challenge,and to identify  the  characteristics  of  NCWS  patients  with  nickel  allergy...
February 2, 2017: Nutrients
https://www.readbyqxmd.com/read/28143523/immune-and-biochemical-responses-in-skin-differ-between-bovine-hosts-genetically-susceptible-and-resistant-to-the-cattle-tick-rhipicephalus-microplus
#13
Alessandra Mara Franzin, Sandra Regina Maruyama, Gustavo Rocha Garcia, Rosane Pereira Oliveira, José Marcos Chaves Ribeiro, Richard Bishop, Antônio Augusto Mendes Maia, Daniela Dantas Moré, Beatriz Rossetti Ferreira, Isabel Kinney Ferreira de Miranda Santos
BACKGROUND: Ticks attach to and penetrate their hosts' skin and inactivate multiple components of host responses in order to acquire a blood meal. Infestation loads with the cattle tick, Rhipicephalus microplus, are heritable: some breeds carry high loads of reproductively successful ticks, whereas in others, few ticks feed and reproduce efficiently. METHODS: In order to elucidate the mechanisms that result in the different outcomes of infestations with cattle ticks, we examined global gene expression and inflammation induced by tick bites in skins from one resistant and one susceptible breed of cattle that underwent primary infestations with larvae and nymphs of R...
January 31, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28131447/emission-characteristics-of-allergenic-terpenols-in-pm2-5-released-from-incense-burning-and-the-effect-of-light-on-the-emissions
#14
Su-Ching Kuo, Ying I Tsai
This study investigated allergenic terpenol compounds in incense powder and smoke. The powder of two Thai brands contained higher concentrations of terpenols up to 6.15 times higher than those of two Taiwanese brands. Consequently, Thai incense makers face a higher potential risk of contact dermatitis than Taiwanese incense makers do. d-Limonene was the primary terpenol compound in the powder of Thai B (64.0%) and Thai Y (31.5%), sold in Thailand. By contrast, anisyl alcohol was the primary terpenol compound in the powder of LST (40...
January 25, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28128086/vesicular-contact-reaction-may-progress-into-erythema-multiforme
#15
Magdalena Czarnecka-Operacz, Dorota Jenerowicz, Joanna Szulczyńska-Gabor, Ewa Teresiak-Mikołajczak, Joanna Szyfter-Harris, Monika Bowszyc-Dmochowska
Dear Editor, Erythema multiforme is considered an acute skin condition, characterized by a self-limiting and sometimes recurrent course. It is regarded as a type IV hypersensitivity reaction associated with certain infections, medications, and other various triggers. Allergic contact dermatitis is in turn a delayed type of induced allergy as a result of cutaneous contact with a specific allergen to which the patient develops specific sensitivity. This type of cutaneous reaction is associated with inflammation manifesting with erythema, edema, and vesicles...
December 2016: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/28121139/structure-potency-relationships-for-epoxides-in-allergic-contact-dermatitis
#16
David W Roberts, Aynur Aptula, Anne Marie Api
Epoxides are known or proposed to be involved in skin sensitization in various ways. Some are encountered directly, and others have been shown to be formed abiotically and metabolically from various unsaturated chemicals. They can react as SN2 electrophiles. To date no quantitative mechanistic models (QMMs) are known for skin sensitization potency of this subcategory of SN2 electrophiles. Here we have considered the reaction mechanistic chemistry of epoxides and combined published experimental kinetic data (rate constants k for reaction with a cysteine-based peptide) together with calculated hydrophobicity data (logP) to derive a QMM correlating potency in the local lymph node assay (LLNA), expressed as EC3, with a relative alkylation index (RAI, calculated as logk + 0...
January 25, 2017: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/28117878/siramesine-causes-preferential-apoptosis-of-mast-cells-in-skin-biopsies-from-psoriatic-lesions
#17
E Hagforsen, M Lampinen, A Paivandy, S Weström, H Velin, S Öberg, G Pejler, O Rollman
BACKGROUND: Skin mast cells are implicated as detrimental effector cells in various inflammatory skin diseases such as contact eczema, atopic dermatitis and psoriasis. Selective reduction of cutaneous mast cells, e.g. by inducing targeted apoptosis, might prove a rational and efficient therapeutic strategy in dermatoses negatively influenced by mast cells. OBJECTIVES: The objective of the present study was to evaluate whether a lysosomotropic agent such as siramesine can cause apoptosis of mast cells present in psoriatic lesions...
January 24, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28111785/appropriate-testing-of-isothiazolinones-in-children
#18
Alina Goldenberg, Michael Lipp, Sharon E Jacob
BACKGROUND/OBJECTIVE: The isothiazolinones methylchloroisothiazolinone (MCI) and methylisothiazolinone (MI) are prevalent pediatric contact sensitizers. MI allergic contact dermatitis (ACD) is underreported in the literature. The objective of the current study was to use a database of provider-reported U.S. pediatric patch test cases to evaluate the positive patch test (PPT) prevalence rates of the combined preservative test substrate MCI/MI and of MI alone. METHODS: U...
January 23, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28110709/chromium-vi-contact-dermatitis-getting-closer-to-understanding-the-underlying-mechanisms-of-toxicity-and%C3%A2-sensitization
#19
Jeroen Buters, Tilo Biedermann
Various haptens trigger innate immune pathways and/or induce cytotoxicity as a part of sensitization. Adam et al. decipher in vitro the mechanisms by which chromium(VI) induces inflammation, the likely prerequisites for toxicity, sensitization, and allergic contact dermatitis against chromium(VI). Importantly, and in line with other observations, chromium(VI), but not chromium(III) (or Ni(II)), induces mitochondrial reactive oxygen species accumulation. Mitochondrial reactive oxygen species in turn activate the NLRP3 inflammasome, allowing increased IL-1β processing and secretion, which likely underlies both chromium(VI)-induced cutaneous toxicity and sensitization...
February 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28110699/high-concentration-topical-capsaicin-may-abolish-the-clinical-manifestations-of-allergic-contact-dermatitis-by-effects-on-induction-and-elicitation
#20
Hjalte H Andersen, Jesper Elberling, Lars Arendt-Nielsen
Allergic contact dermatitis (ACD) is a common skin condition caused by a type-IV hypersensitivity reaction. Even though ACD is considered as a T-cell mediated disease, indications exists that peptidergic nerve fibers at the site of allergen exposure and associated with the draining lymph node play a prominent role in both induction and elicitation of ACD. This neuro-immune cross talk seems rely on neuropeptides such as Substance P secreted by nerve fiber terminals. It is hypothesized that local complete or partial cutaneous denervation/defunctionalization of peptidergic fibers in humans could be a feasible approach towards treating allergic contact dermatitis...
February 2017: Medical Hypotheses
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