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https://www.readbyqxmd.com/read/28822013/biomonitoring-of-chemicals-in-biota-of-two-wetland-protected-areas-exposed-to-different-levels-of-environmental-impact-results-of-the-previeni-project
#1
Cristiana Guerranti, Guido Perra, Eva Alessi, Davide Baroni, Dante Caserta, Donatella Caserta, Augusto De Sanctis, Emiliano Leonida Fanello, Cinzia La Rocca, Michela Mariottini, Monia Renzi, Sabrina Tait, Carlo Zaghi, Alberto Mantovani, Silvano Ettore Focardi
The PREVIENI project (funded by the Ministry of Environment) investigated the exposure to endocrine disrupters in samples of human population and environmental biota in Italy. The environmental biomonitoring considered two Italian WWF Oasis, with the aim to compare the presence and effects of endocrine disruptors in organisms from two protected natural areas, respectively, upstream and downstream a chemical emission site. Chemical analysis of pollutants' tissue levels was made on tissues from earthworm, barbell, trout, and coot, selected as bioindicator organisms...
August 18, 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28818713/historical-human-exposure-to-perfluoroalkyl-acids-in-the-united-states-and-australia-reconstructed-from-biomonitoring-data-using-population-based-pharmacokinetic-modelling
#2
Melissa I Gomis, Robin Vestergren, Matthew MacLeod, Jochen F Mueller, Ian T Cousins
Perfluorooctanoic acid (PFOA), perfluorooctanesulfonic acid (PFOS) and perfluorohexanesulfonic acid (PFHxS) are found in the blood of humans and wildlife worldwide. Since the beginning of the 21st century, a downward trend in the human body burden, especially for PFOS and PFOA, has been observed while there is no clear temporal trend in wildlife. The inconsistency between the concentration decline in human serum and in wildlife could be indicative of a historical exposure pathway for humans linked to consumer products that has been reduced or eliminated...
August 14, 2017: Environment International
https://www.readbyqxmd.com/read/28818342/novel-treatment-technologies-for-pfas-compounds-a-critical-review
#3
Katarzyna H Kucharzyk, Ramona Darlington, Mark Benotti, Rula Deeb, Elisabeth Hawley
Perfluorinated compounds such as perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) have recently drawn great attention due to their wide distribution in aquatic environments. The understanding of the physicochemical properties and fate and transport of PFAs in groundwater is still limited. Preliminary studies indicate that these compounds can readily bioaccumulate and pose human and animal health concerns. Due to their physicochemical properties, PFOS and PFOA are water soluble, nonvolatile and persistent in the environment, which is a cause of concern related to their treatment with conventional remediation technologies...
August 14, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28802206/perfluoroalkyl-substance-exposure-and-urine-cc16-levels-among-asthmatics-a-case-control-study-of-children
#4
Yang Zhou, Wen-Wen Bao, Zhengmin Min Qian, Sarah Dee Geiger, Katelyn L Parrish, Bo-Yi Yang, Yungling Leo Lee, Guang-Hui Dong
BACKGROUND: Studies have reported an association between serum perfluoroalkyl substances (PFASs) and asthma. However, few studies have examined the possible associations between PFASs and the 16-kDa club cell secretory protein (Clara) (CC16) level, a prominent biomarker of asthma, among adolescents. METHODS: We recruited a total of 231 asthmatic children and 225 non-asthmatic controls in the Genetic and Biomarkers study for Childhood Asthma (GBCA) in northern Taiwan from 2009 to 2010...
August 9, 2017: Environmental Research
https://www.readbyqxmd.com/read/28800911/distribution-profiles-of-per-and-poly-fluoroalkyl-substances-pfass-and-their-re-regulation-by-ocean-currents-in-the-east-and-south-china-sea
#5
Hongyuan Zheng, Feng Wang, Zhen Zhao, Yuxin Ma, Haizhen Yang, Zhibo Lu, Minggang Cai, Minghong Cai
We investigated the distribution of 17 individual per- and polyfluoroalkyl substances (PFASs) in 42 surface water samples collected from the East and South China Seas (7.0-36.0°N, 110.0°N-123.0°E). Concentrations of 7 individual PFASs, including perfluorobutane sulfonate (PFBS), perfluorohexane sulfonate (PFHxS), perfluoropentanoic acid (PFPA), perfluorohexanoate (PFHxA), perfluoroheptanoate (PFHpA), perfluorooctanoic acid (PFOA), and perfluorooctane sulfonamide (FOSA), were quantified in the East China Sea, but only concentrations of PFOA and FOSA were quantified in the South China Sea...
August 9, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28800531/changes-on-lipid-peroxidation-enzymatic-activities-and-gene-expression-in-planarian-dugesia-japonica-following-exposure-to-perfluorooctanoic-acid
#6
Zuoqing Yuan, Zili Miao, Xiaoning Gong, Baoying Zhao, Yuanyuan Zhang, Hongdou Ma, Jianyong Zhang, Bosheng Zhao
We investigated perfluorooctanoic acid (PFOA)-induced stress response in planarians. We administered different concentrations of PFOA to planarians for up to 10 d. PFOA exposure resulted in significant concentration-dependent elevations in lipid peroxidation, glutathione S-transferase and caspase-3 protease activities, and a significant decline in glutathione peroxidase activities compared with control groups. Exposure to PFOA significantly up-regulated the heat shock proteins hsp70 and hsp90, and p53, and down-regulated hsp40 compared with controls...
August 8, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28800519/emerging-poly-and-perfluoroalkyl-substances-in-the-aquatic-environment-a-review-of-current-literature
#7
REVIEW
Feng Xiao
Poly- and perfluoroalkyl substances (PFASs) comprise a group of synthetic organic surfactants with a wide range of industrial and commercial applications. A few PFASs such as perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) are now known to be ubiquitously present in the aquatic environment. They have become a global concern because of the toxicity and bioaccumulative properties. With the increasing availability of high-resolution mass spectrometers, many novel PFASs have been identified. Studies published between 2009 and 2017 have discovered 455 new PFASs (including nine fully and 446 partially fluorinated compounds), 45%, 29%, 17%, and 8% of which are anions, zwitterions, cations, and neutrals, respectively...
July 15, 2017: Water Research
https://www.readbyqxmd.com/read/28800414/global-distribution-of-perfluorochemicals-pfcs-in-potential-human-exposure-source-a-review
#8
REVIEW
Jun-Meng Jian, Ying Guo, Lixi Zeng, Liu Liang-Ying, Xingwen Lu, Fei Wang, Eddy Y Zeng
Human exposure to perfluorochemicals (PFCs) has attracted mounting attention due to their potential harmful effects. Breathing, dietary intake, and drinking are believed to be the main routes for PFC entering into human body. Thus, we profiled PFC compositions and concentrations in indoor air and dust, food, and drinking water with detailed analysis of literature data published after 2010. Concentrations of PFCs in air and dust samples collected from home, office, and vehicle were outlined. The results showed that neutral PFCs (e...
August 8, 2017: Environment International
https://www.readbyqxmd.com/read/28791554/biomarker-responses-of-earthworms-eisenia-fetida-to-soils-contaminated-with-perfluorooctanoic-acid
#9
Yiyi Zhao, Guangde Li, Daqian Qi, Liangqi Sun, Changlei Wen, Suzhen Yin
Perfluorooctanoic acid (PFOA) is considered a persistent environmental pollutant. The aim of this study was to assess the potential toxicity of PFOA to earthworms (Eisenia fetida) in artificial soil. The activities of superoxide dismutase (SOD), catalase (CAT), peroxidase (POD), and glutathione S-transferase (GST) as well as the contents of malondialdehyde (MDA) were measured after exposure to 0, 5, 10, 20, and 40 mg kg(-1) PFOA in soils for 7, 14, 21, and 28 days. The results showed that SOD activity increased at 14 days and decreased from 21 to 28 days; MDA levels were highest in the treatment with 40 mg kg(-1) PFOA after 28 days of exposure...
August 8, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28783897/gonadal-intersex-in-smallmouth-bass-micropterus-dolomieu-from-northern-indiana-with-correlations-to-molecular-biomarkers-and-anthropogenic-chemicals
#10
Ahmed Abdel-Moneim, Daragh Deegan, Jiejun Gao, Chloe De Perre, Jarrod S Doucette, Byron Jenkinson, Linda Lee, Maria S Sepúlveda
Over the past decade, studies have shown that exposure to endocrine disrupting chemicals (EDCs) can cause gonadal intersex in fish. Smallmouth bass (Micropterus dolomieu) males appear to be highly susceptible to developing testicular oocytes (TO), the most prevalent form of gonadal intersex, as observed in various areas across the U.S. In this study, prevalence and severity of TO was quantified for smallmouth bass sampled from the St. Joseph River in northern Indiana, intersex biomarkers were developed, and association between TO prevalence and organic contaminants were explored...
July 31, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28780851/first-report-on-the-occurrence-and-bioaccumulation-of-hexafluoropropylene-oxide-trimer-acid-hfpo-ta-an-emerging-concern
#11
Yitao Pan, Hongxia Zhang, Qianqian Cui, Nan Sheng, Leo Wai-Yin Yeung, Yong Guo, Yan Sun, Jiayin Dai
Here we report on the occurrence of a novel perfluoroalkyl ether carboxylic acid (PFECA), ammonium perfluoro-2-[(propoxy)propoxy]-1-propanoate (HFPO-TA), in surface water and common carps (Cyprinus carpio) collected from Xiaoqing River and in residents residing near a fluoropolymer production plant in Huantai County, China. Compared with the levels in the upstream of Xiaoqing River, HFPO-TA concentrations (5200-68500 ng/L) were approximately 120-1600 times higher at the downstream, after receiving fluoropolymer plant effluent from a tributary...
August 7, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28759222/a-permeability-limited-physiologically-based-pharmacokinetic-pbpk-model-for-perfluorooctanoic-acid-pfoa-in-male-rats
#12
Weixiao Cheng, Carla Ng
Physiologically based pharmacokinetic (PBPK) modeling is a powerful in silico tool that can be used to simulate the toxicokinetics and tissue distribution of xenobiotic substances, such as perfluorooctanoic acid (PFOA) in organisms. However, most existing PBPK models have been based on the flow-limited assumption and largely rely on in vivo data for parameterization. In this study, we propose a permeability-limited PBPK model to estimate the toxicokinetics and tissue distribution of PFOA in male rats. Our model considers the cellular uptake and efflux of PFOA via both passive diffusion and transport facilitated by various membrane transporters, association with serum albumin in circulatory and extracellular spaces, and association with intracellular proteins in liver and kidney...
July 31, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28754927/perfluoroalkyl-substances-in-human-bone-concentrations-in-bones-and-effects-on-bone-cell-differentiation
#13
A Koskela, J Koponen, P Lehenkari, M Viluksela, M Korkalainen, J Tuukkanen
Perfluoroalkyl substances (PFAS), including two most commonly studied compounds perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA), are widely distributed environmental pollutants, used extensively earlier. Due to their toxicological effects the use of PFAS is now regulated. Based on earlier studies on PFOA's distribution in bone and bone marrow in mice, we investigated PFAS levels and their possible link to bone microarchitecture of human femoral bone samples (n = 18). Soft tissue and bone biopsies were also taken from a 49-year old female cadaver for PFAS analyses...
July 28, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28749778/serum-vaccine-antibody-concentrations-in-adolescents-exposed-to-perfluorinated-compounds
#14
Philippe Grandjean, Carsten Heilmann, Pal Weihe, Flemming Nielsen, Ulla B Mogensen, Esben Budtz-Jørgensen
BACKGROUND: Postnatal exposure to perfluorinated alkylate substances (PFASs) is associated with lower serum concentrations of specific antibodies against certain childhood vaccines at 7 y. OBJECTIVES: We prospectively followed a Faroese birth cohort to determine these associations at 13 y. METHODS: In 516 subjects (79% of eligible cohort members) who were 13 years old, serum concentrations of PFASs and of antibodies against diphtheria and tetanus were measured and were compared with data from the previous examination at 7 y...
July 26, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28749130/fluorination-of-boron-doped-diamond-film-electrodes-for-minimization-of-perchlorate-formation
#15
Pralay Gayen, Brian P Chaplin
This research investigated the effects of surface fluorination on both rates of organic compound oxidation (phenol, terephthalic acid (TA)) and ClO4(-) formation at boron-doped diamond (BDD) film anodes at 22(o) C. Different fluorination methods (i.e., electrochemical oxidation with perfluorooctanoic acid (PFOA), radio frequency plasma, and silanization) were used to incorporate fluorinated moieties on the BDD surface, which was confirmed by X-ray photoelectron spectroscopy (XPS). The silanization method was found to be the most effective fluorination method using a 1H, 1H, 2H, 2H perfluorodecyltrichlorosilane (aliphatic silane) precursor to form a self assembled monolayer (SAM) on the oxygenated BDD surface...
July 27, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28738507/gender-specific-associations-between-serum-isomers-of-perfluoroalkyl-substances-and-blood-pressure-among-chinese-isomers-of-c8-health-project-in-china
#16
Wen-Wen Bao, Zhengmin Min Qian, Sarah Dee Geiger, Echu Liu, Yimin Liu, Si-Quan Wang, Wayne R Lawrence, Bo-Yi Yang, Li-Wen Hu, Xiao-Wen Zeng, Guang-Hui Dong
Previous studies have demonstrated associations of perfluoroalkyl substances (PFASs), a group of highly persistent chemicals ubiquitous in wildlife and humans, with hypertension, but the relationships are mixed. Furthermore, academic literature on the relationship between isomers of PFASs and blood pressure (BP) and hypertension in populations from a higher pollution area is scant. We studied 1612 Chinese adults, ages 22-96years old, from Shenyang, China, utilizing high performance liquid chromatography-mass spectrometry to analyze isomers of perfluorooctanesulfonate (PFOS), perfluorooctanoate (PFOA), and other PFASs in blood serum...
July 18, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28738424/use-of-high-throughput-in-vitro-toxicity-screening-data-in-cancer-hazard-evaluations-by-iarc-monograph-working-groups
#17
Weihsueh A Chiu, Kathryn Z Guyton, Matthew T Martin, David M Reif, Ivan Rusyn
Evidence regarding carcinogenic mechanisms serves a critical role in International Agency for Research on Cancer (IARC) Monograph evaluations. Three recent IARC Working Groups pioneered inclusion of the US Environmental Protection Agency (EPA) ToxCast program high-throughput screening (HTS) data to supplement other mechanistic evidence. In Monograph V110, HTS profiles were compared between perfluorooctanoic acid (PFOA) and prototypical activators across multiple nuclear receptors. For Monograph V112 -113, HTS assays were mapped to 10 key characteristics of carcinogens identified by an IARC expert group, and systematically considered as an additional mechanistic data stream...
July 24, 2017: ALTEX
https://www.readbyqxmd.com/read/28738170/removal-of-pfoa-in-groundwater-by-fe-0-and-mno2-nanoparticles-under-visible-light
#18
Jia Liu, Lindsey Weinholtz, Linan Zheng, Meisam Peiravi, Yan Wu, Da Chen
The main objective of this study was to find a cost-effective, efficient and environmentally-friendly solution to remove perfluorooctanic acid (PFOA) from groundwater by using Fe(0) and MnO2 nanoparticles. The selected method was expected to be applicable to the remediation of PFOA-contaminated groundwater. Phytotoxicity of the nanoparticle treatment was studied to demonstrate the safe application of the nanomaterials. Zero-valent Fe (100 mg L(-1)) and MnO2 (100 mg L(-1)) nanoparticles, produced in our lab, were used to remove PFOA up to 10 mg L(-1)...
July 24, 2017: Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering
https://www.readbyqxmd.com/read/28733818/occurrence-and-distribution-of-six-selected-endocrine-disrupting-compounds-in-surface-and-groundwaters-of-the-romagna-area-north-italy
#19
Emanuela Pignotti, Marinella Farré, Damià Barceló, Enrico Dinelli
Endocrine disrupting compounds (EDCs) are a wide group of contaminants of emerging concern known to be harmful for organisms. The aim of the study was to assess the occurrence and distribution of six EDCs (estrone-E1, ß-estradiol-E2, 17α-ethinylestradiol-EE2, bisphenol A-BPA, perfluooctanoic acid-PFOA, perfluorooctane sulfonate-PFOS) in the Apenninic rivers and groundwaters of the Romagna area (North of Italy). Groundwaters were unaffected by EDC contamination, while all classes of compounds were detected at concentrations above the method quantification limit (MQL) in the majority of the river bodies...
July 21, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28732399/analysis-of-emerging-organic-contaminants-in-water-fish-and-suspended-particulate-matter-spm-in-the-joint-danube-survey-using-solid-phase-extraction-followed-by-uhplc-ms-ms-and-gc-ms-analysis
#20
Robert Loos, Simona Tavazzi, Giulio Mariani, Gert Suurkuusk, Bruno Paracchini, Gunther Umlauf
In the third Joint Danube Survey (JDS3), emerging organic contaminants were analysed in the dissolved water phase of samples from the Danube River and its major tributaries. Analyses were performed using solid-phase extraction (SPE) followed by ultra-high-pressure liquid chromatography triple-quadrupole mass spectrometry (UHPLC-MS-MS) and gas chromatography-mass spectrometry (GC-MS). The polar organic compounds analysed by UHPLC-MS-MS were 1H-benzotriazole, methylbenzotriazoles, carbamazepine, 10,11-dihydro-10,11-dihydroxy-carbamazepine, diclofenac, sulfamethox-azole, 2,4-D (2,4-dichlorophenoxyacetic acid), MCPA (2-methyl-4-chlorophenoxyacetic acid), metolachlor, cybutryne (irgarol), terbutryn, DEET (N,N-diethyl-m-toluamide), and several perfluoroalkyl acids (C6-C9; C8=perfluorooctanoic acid (PFOA)) and perfluorooctansulfonic acid (PFOS)...
July 17, 2017: Science of the Total Environment
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