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https://www.readbyqxmd.com/read/29027000/occupational-exposure-to-perfluoroalkyl-substances-and-serum-levels-of-perfluorooctanesulfonic-acid-pfos-and-perfluorooctanoic-acid-pfoa-in-an-aging-population-from-upstate-new-york-a-retrospective-cohort-study
#1
Eva M Tanner, Michael S Bloom, Qian Wu, Kurunthachalam Kannan, Recai M Yucel, Srishti Shrestha, Edward F Fitzgerald
PURPOSE: Perfluoroalkyl substances (PFASs) are environmentally persistent amphiphilic compounds. Exposure to two PFASs, perfluorooctanesulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) is linked to specific occupations and industries. This study examines the contribution of past occupational PFAS exposure to serum PFOS and PFOA levels among 154 older adults in New York State. METHODS: Serum PFOS and PFOA levels were compared to data from the National Health and Nutrition Examination Survey (NHANES)...
October 12, 2017: International Archives of Occupational and Environmental Health
https://www.readbyqxmd.com/read/29017113/fate-of-bisphenol-a-perfluorooctanoic-acid-and-perfluorooctanesulfonate-in-two-different-types-of-sewage-treatment-works-in-hong-kong
#2
Yu Bon Man, Ka Lai Chow, Yiu Fai Tsang, Frankie Tat Kwong Lau, Wing Cheong Fung, Ming Hung Wong
This study aimed at investigating the removal efficiencies of perfluorooctanoate (PFOA), perfluorooctane sulfonate (PFOS) and bisphenol A (BPA) of two major sewage treatment works in Hong Kong: Stonecutters Island STW (SCISTW) which adopts chemically enhanced primary treatment (CEPT) process and Sha Tin STW (STSTW) which employs biological treatment. Liquid portion (LP) and particulate matter (PM) of liquid sewage samples and sludge samples were collected and followed by liquid chromatograph system. It was found that BPA (44...
October 3, 2017: Chemosphere
https://www.readbyqxmd.com/read/28994293/investigation-of-the-best-approach-for-assessing-human-exposure-to-poly-and-perfluoroalkyl-substances-through-indoor-air
#3
Juan A Padilla-Sánchez, Eleni Papadopoulou, Somrutai Poothong, Line S Haug
Per- and polyfluoroalkyl substances (PFASs), including fluorotelomer alcohols (FTOHs), perfluoroalkyl sulfonamidoethanols (FOSEs) and perfluoroalkyl sulfonamides (FOSAs) were assessed in 61 residential indoor air and 15 personal air samples collected in Oslo area, Norway. FTOHs were detected in all samples, and the median concentrations in residential indoor air were 2971, 10363 and 3115 pg m-3 for 6:2, 8:2 and 10:2 FTOH, respectively. This is similar to or higher than previously reported in studies from the same geographical area and worldwide...
October 10, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28993126/per-and-polyfluoroalkyl-substances-in-sera-from-children-3-to-11-years-of-age-participating-in-the-national-health-and-nutrition-examination-survey-2013-2014
#4
Xiaoyun Ye, Kayoko Kato, Lee-Yang Wong, Tao Jia, Akil Kalathil, John Latremouille, Antonia M Calafat
Several per- and polyfluoroalkyl substances (PFAS) have been measured in U.S. National Health and Nutrition Examination Survey (NHANES) participants 12 years of age and older since 1999-2000, but PFAS data using NHANES individual samples among children younger than 12 years do not exist. To obtain the first nationally representative PFAS exposure data in U.S. children, we quantified serum concentrations of 14 PFAS including perfluorooctane sulfonic acid (PFOS), perfluorooctanoic acid (PFOA), perfluorohexane sulfonic acid (PFHxS), and perfluorononanoic acid (PFNA), in a nationally representative subsample of 639 3-11year old participants in NHANES 2013-2014...
September 29, 2017: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/28987408/perfluorohexadecanoic-acid-increases-paracellular-permeability-in-endothelial-cells-through-the-activation-of-plasma-kallikrein-kinin-system
#5
Qian S Liu, Fang Hao, Zhendong Sun, Yanmin Long, Qunfang Zhou, Guibin Jiang
Per- and polyfluoroalkyl substances (PFASs) are ubiquitous and high persistent in human blood, thus potentially inducing a myriad of deleterious consequences. Plasma kallikrein-kinin system (KKS), which physiologically regulates vascular permeability, is vulnerable to exogenous stimulators, like PFASs with long-chain alkyl backbone substituted by electronegative fluorine. The study on the interactions of PFASs with the KKS and the subsequent effects on vascular permeability would be helpful to illustrate how the chemicals penetrate the biological vascular barriers to reach different tissues...
October 3, 2017: Chemosphere
https://www.readbyqxmd.com/read/28982594/endocrine-disruptor-effect-of-perfluorooctane-sulfonic-acid-pfos-and-perfluorooctanoic-acid-pfoa-on-porcine-ovarian-cell-steroidogenesis
#6
Andrea Chaparro-Ortega, Miguel Betancourt, Patricia Rosas, Francisco G Vázquez-Cuevas, Roberto Chavira, Edmundo Bonilla, Eduardo Casas, Yvonne Ducolomb
Previous studies with perfluorooctanesulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) indicate that they act as endocrine disruptors, in addition to inducing alterations and damaging reproductive health; however, the biological mechanisms by which these disorders are produced are not yet understood. The aim of this study was to analyze the effect of PFOS and PFOA on in vitro steroidogenic secretion in porcine theca and granulosa cells, with or without gonadotropic stimulation. Granulosa and theca cells were isolated and cultured...
October 2, 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/28974480/plasma-concentrations-of-per-and-polyfluoroalkyl-substances-at-baseline-and-associations-with-glycemic-indicators-and-diabetes-incidence-among-high-risk-adults-in-the-diabetes-prevention-program-trial
#7
Andres Cardenas, Diane R Gold, Russ Hauser, Ken P Kleinman, Marie-France Hivert, Antonia M Calafat, Xiaoyun Ye, Thomas F Webster, Edward S Horton, Emily Oken
BACKGROUND: Several per- and polyfluoroalkyl substances (PFAS) are ubiquitous anthropogenic pollutants almost universally detected in humans. Experimental evidence indicates that PFAS alter glucose metabolism and insulin secretion. However, epidemiological studies have yielded inconsistent results. OBJECTIVE: We sought to examine associations between plasma PFAS concentrations, glycemic indicators, and diabetes incidence among high-risk adults. METHODS: Within the Diabetes Prevention Program (DPP), a trial for the prevention of type 2 diabetes among high-risk individuals, we quantified baseline plasma concentrations of nine PFAS among 957 participants randomized to a lifestyle intervention or placebo...
October 2, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28963602/occurrence-and-source-identification-of-perfluoroalkyl-acids-pfaas-in-the-metedeconk-river-watershed-new-jersey
#8
Nicholas A Procopio, Robert Karl, Sandra M Goodrow, Joseph Maggio, Judith B Louis, Thomas B Atherholt
The Brick Township Municipal Utilities Authority (BTMUA), which relies on the Metedeconk River as its primary source of water supply, initiated a perfluoroalkyl acid (PFAA) source trackdown study in collaboration with the New Jersey Department of Environmental Protection (NJDEP) after discovering that the concentration of one PFAA, perfluorooctanoic acid (PFOA), was elevated at their raw surface water intake. Water samples were collected over eight sampling events between September 2011 and July 2014. Samples included surface water, groundwater, stormwater, sanitary sewer water, and commercial/industrial process water...
September 30, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28947262/perfluorooctanoic-acid-exposure-disturbs-glucose-metabolism-in-mouse-liver
#9
Fei Zheng, Nan Sheng, Hongxia Zhang, Shengmin Yan, Jianhai Zhang, Jianshe Wang
Environmental pollutants such as perfluorooctanoic acid (PFOA) can influence human metabolism processes and are associated with certain metabolic diseases. To investigate the effect of PFOA on liver glucose homeostasis, adult male Balb/c mice were orally administered 1.25mg/kg of PFOA for 28d consecutively. Compared with the control mice, the body weights of the PFOA-treated mice were unchanged following exposure. However, PFOA exposure increased fasting blood glucose levels and decreased glycogen and glucose content in the liver of treated mice, but did not influence blood insulin significantly...
September 23, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28934720/prenatal-exposure-to-perfluoroalkyl-substances-and-cardiometabolic-risk-in-children-from-the-spanish-inma-birth-cohort-study
#10
Cyntia B Manzano-Salgado, Maribel Casas, Maria-Jose Lopez-Espinosa, Ferran Ballester, Carmen Iñiguez, David Martinez, Dora Romaguera, Silvia Fernández-Barrés, Loreto Santa-Marina, Mikel Basterretxea, Thomas Schettgen, Damaskini Valvi, Jesus Vioque, Jordi Sunyer, Martine Vrijheid
BACKGROUND: Perfluoroalkyl substances (PFAS) may affect body mass index (BMI) and other components of cardiometabolic (CM) risk during childhood, but evidence is scarce and inconsistent. OBJECTIVES: We estimated associations between prenatal PFAS exposures and outcomes relevant to cardiometabolic risk, including a composite CM-risk score. METHODS: We measured perfluorohexanesulfonic acid (PFHxS), perfluorooctanesulfonic acid (PFOS), perfluorooctanoic acid (PFOA), and perfluorononanoic acid (PFNA) in maternal plasma (first trimester)...
September 20, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28934691/the-role-of-ppar-alpha-in-perfluorooctanoic-acid-induced-developmental-cardiotoxicity-and-l-carnitine-mediated-protection-results-of-in-ovo-gene-silencing
#11
Meng Zhao, Qixiao Jiang, Min Geng, Li Zhu, Yunqiu Xia, Aashish Khanal, Chunbo Wang
Perfluorooctanoic acid (PFOA) is a persistent organic pollutant. This study established an in ovo peroxisome proliferator-activated receptor alpha (PPAR alpha) silencing model in chicken embryo heart, and investigated the role of PPAR alpha in PFOA induced developmental cardiotoxicity. The in ovo silencing was achieved by introducing lentivirus expressing PPAR alpha siRNA into ED2 chicken embryo via microinjection (0.05ul/g egg weight). Transfection efficacy was confirmed by fluorescent microscopy and western blotting...
September 14, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28923343/association-among-total-serum-isomers-of-perfluorinated-chemicals-glucose-homeostasis-lipid-profiles-serum-protein-and-metabolic-syndrome-in-adults-nhanes-2013-2014
#12
Hui-Shan Liu, Li-Li Wen, Pei-Lun Chu, Chien-Yu Lin
Perfluorinated chemicals (PFCs) have been used widely in consumer products manufacture. Recent in vitro as well as animal studies have found that there are different toxicity and pharmacokinetic profiles between isomers of perfluorooctanoic acid (PFOA) and/or perfluorooctane sulfonate (PFOS). However, the differential effects of linear or branched PFOA/PFOS isomers on human beings have never been reported. Herein, we examined 1871 adult subjects (age older than 18 years) from the National Health and Nutrition Examination Survey (NHANES) 2013-2014 to determine the association between the isomers of PFOA/PFOS and serum biochemistry profiles, including glucose, lipids, protein and components of metabolic syndrome (MS)...
September 15, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28919516/time-dependent-effects-of-perfluorinated-compounds-on-viability-in-cerebellar-granule-neurons-dependence-on-carbon-chain-length-and-functional-group-attached
#13
Hanne Friis Berntsen, Cesilie Granum Bjørklund, Jean-Nicolas Audinot, Tim Hofer, Steven Verhaegen, Esther Lentzen, Arno Christian Gutleb, Erik Ropstad
The toxicity of long chained perfluoroalkyl acids (PFAAs) has previously been reported to be related to the length of the perfluorinated carbon chain and functional group attached. In the present study, we compared the cytotoxicity of six PFAAs, using primary cultures of rat cerebellar granule neurons (CGNs). Two perfluoroalkyl sulfonic acids (PFSAs, chain length C6 and C8) and four perfluoroalkyl carboxylic acids (PFCAs, chain length C8-C11) were studied. These PFAAs have been detected in human blood and the brain tissue of mammals...
September 15, 2017: Neurotoxicology
https://www.readbyqxmd.com/read/28917208/prenatal-exposure-to-perfluoroalkyl-substances-and-birth-outcomes-in-a-spanish-birth-cohort
#14
Cyntia B Manzano-Salgado, Maribel Casas, Maria-Jose Lopez-Espinosa, Ferran Ballester, Carmen Iñiguez, David Martinez, Olga Costa, Loreto Santa-Marina, Eva Pereda-Pereda, Thomas Schettgen, Jordi Sunyer, Martine Vrijheid
BACKGROUND: Prenatal perfluorooctanoate (PFOA) exposure has been associated with reduced birth weight but maternal glomerular filtration rate (GFR) may attenuate this association. Further, this association remains unclear for other perfluoroalkyl substances (PFAS), such as perfluorooctane sulfonate (PFOS), perfluorohexane sulfonate (PFHxS), and perfluorononanoate (PFNA). We estimated associations between prenatal PFAS exposure and birth outcomes, and the influence of GFR, in a Spanish birth cohort...
September 13, 2017: Environment International
https://www.readbyqxmd.com/read/28917116/thermal-and-photo-induced-degradation-of-perfluorinated-carboxylic-acids-kinetics-and-mechanism
#15
Jiaoqin Liu, Ruijuan Qu, Zunyao Wang, Itza Mendoza-Sanchez, Virender K Sharma
Perfluorinated carboxylic acids (PFCAs) of different carbon chain lengths are chemicals of concern to human health and their removal, using conventional remediation technologies, is challenging. The present paper pursuits thermal and photo-induced degradation of PFCAs (F(CF2)nCOOH, n = 1-9) under various concentrations of four different acids (HNO3, H2SO4, HCl, and H3PO4) covering a range of strong acidic to basic pH. For thermal-induced experiments, the temperature was set at 40 °C, 60 °C, and 80 °C at acid strengths of 0...
September 6, 2017: Water Research
https://www.readbyqxmd.com/read/28915454/assessing-the-potential-contributions-of-additional-retention-processes-to-pfas-retardation-in-the-subsurface
#16
Mark L Brusseau
A comprehensive understanding of the transport and fate of per- and poly-fluoroalkyl substances (PFAS) in the subsurface is critical for accurate risk assessments and design of effective remedial actions. A multi-process retention model is proposed to account for potential additional sources of retardation for PFAS transport in source zones. These include partitioning to the soil atmosphere, adsorption at air-water interfaces, partitioning to trapped organic liquids (NAPL), and adsorption at NAPL-water interfaces...
September 12, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28913736/ptfe-coated-non-stick-cookware-and-toxicity-concerns-a-perspective
#17
Muhammad Sajid, Muhammad Ilyas
PTFE is used as an inner coating material in non-stick cookware. This unique polymer coating prevents food from sticking in the pans during the cooking process. Such cookware is also easy to wash. At normal cooking temperatures, PTFE-coated cookware releases various gases and chemicals that present mild to severe toxicity. Only few studies describe the toxicity of PTFE but without solid conclusions. The toxicity and fate of ingested PTFE coatings are also not understood. Moreover, the emerging, persistent, and well-known toxic environmental pollutant PFOA is also used in the synthesis of PTFA...
October 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28901245/investigation-into-perfluoroalkyl-substances-pfass-in-a-cranberry-bog-method-development-and-sampling-results
#18
Susan Genualdi, Nahyun Jeong, Lowri deJager, Timothy Begley
The contamination of groundwater and surface water from previous uses of perfluoroalkyl substances (PFASs), particularly products containing the contaminants perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA), has become a concern for drinking water and as a potential exposure route to the food supply. In 2016, the Food and Drug Administration (FDA) was asked to investigate a bog in Massachusetts where the surface water was believed to be contaminated with PFASs. As a result, a method was developed for the analysis of PFASs in cranberries, and water and fruit from the affected bog were evaluated...
September 13, 2017: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/28890218/serum-perfluoroalkyl-substances-and-cardiometabolic-consequences-in-adolescents-exposed-to-the-world-trade-center-disaster-and-a-matched-comparison-group
#19
Tony T Koshy, Teresa M Attina, Akhgar Ghassabian, Joseph Gilbert, Lauren K Burdine, Michael Marmor, Masato Honda, Dinh Binh Chu, Xiaoxia Han, Yongzhao Shao, Kurunthachalam Kannan, Elaine M Urbina, Leonardo Trasande
BACKGROUND: Large amounts of various chemical contaminants, including perfluoroalkyl substances (PFASs), were released at the time of the World Trade Center (WTC) disaster. Thousands of children who lived and/or attended school near the disaster site were exposed to these substances but few studies have examined the possible consequences related to these exposures. OBJECTIVES: To examine the relationship of PFASs serum levels with cardiometabolic profile in children and adolescents enrolled in the World Trade Center Health Registry (WTCHR) and a matched comparison group...
September 7, 2017: Environment International
https://www.readbyqxmd.com/read/28888909/association-of-varus-thrust-with-prevalent-patellofemoral-osteoarthritis-a-cross-sectional-study
#20
Hirotaka Iijima, Naoto Fukutani, Yuko Yamamoto, Masakazu Hiraoka, Kazuyuki Miyanobu, Masashi Jinnouchi, Eishi Kaneda, Takuya Isho, Tomoki Aoyama, Hiroshi Kuroki, Shuichi Matsuda
This cross-sectional study investigated (i) the association of varus thrust during gait with the presence of patellofemoral osteoarthritis (PFOA) in patients with medial knee osteoarthritis (OA) and (ii) patellar alignment in the knees with varus thrust. Participants from orthopedic clinics (n=171; mean age, 73.4 years; 71.9% female) diagnosed with radiographic medial knee OA (Kellgren/Lawrence [K/L] grade ≥1) were included in this study, and underwent gait observation for varus thrust assessment using 2D video analysis...
October 2017: Gait & Posture
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