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https://www.readbyqxmd.com/read/28811679/bisphenol-a-does-not-mimic-estrogen-in-the-promotion-of-the-in-vitro-response-of-murine-dendritic-cells-to-toll-like-receptor-ligands
#1
Marita Chakhtoura, Uma Sriram, Michelle Heayn, Joshua Wonsidler, Christopher Doyle, Joudy-Ann Dinnall, Stefania Gallucci, Rebecca A Roberts
Sex hormones affect immune responses and might promote autoimmunity. Endocrine disrupting chemicals such as bisphenol A (BPA) may mimic their immune effects. Conventional dendritic cells (cDCs) are pivotal initiators of immune responses upon activation by danger signals coming from pathogens or distressed tissues through triggering of the Toll-like receptors (TLRs). We generated in vitro murine cDCs in the absence of estrogens and measured the effects of exogenously added estrogen or BPA on their differentiation and activation by the TLR ligands LPS and CpG...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28811233/stimulation-of-ovarian-cell-proliferation-by-tetrabromobisphenol-a-but-not-tetrachlorobisphenol-a-through-g-protein-coupled-receptor-30
#2
Marta Hoffmann, Justyna Gogola, Małgorzata Kotula-Balak, Anna Ptak
Tetrabromobisphenol A (TBBPA) and tetrachlorobisphenol A (TCBPA) are bisphenol A (BPA) analogs, where the phenolic moieties are substituted with halogens (Br or Cl). Previous studies indicate that BPA has significant proliferative effects on in vitro cultured epithelial ovarian cancer (EOC) cells. Considering this, we analyzed the effects of both TBBPA and TCBPA at 1, 10, and 50nM on ovarian cancer cell proliferation. The majority of malignant ovarian tumors are epithelial in origin, but approximately 10% are classified as ovarian sex cord tumors, with the most common type being granulosa cell tumors (GCTs)...
August 12, 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/28808332/magnetic-microsphere-based-portable-solid-phase-extraction-device-for-on-site-pre-concentration-of-organics-from-large-volume-water-samples
#3
Zhijian Yao, Qingqing Zhao, Yan Ma, Wei Wang, Qing Zhou, Aimin Li
In this research a new magnetic material called M88 was fully synthetized and characterized for the extraction of pharmaceutical and personal care products in water samples. In addition, a portable prototype of magnetic solidphase extraction (MSPE) device was developed for the onsite preconcentration. The MSPE coupling with high performance liquid chromatography-Diode array detector (HPLC-DAD) method was developed and validated for simultaneous analysis of 11 PPCPs (mefenamic acid, chloroamphenicol, ketoprofen, clofibric acid, indometacin, acetylsalicylic acid, bisphenol A, phenylphenol, gemfibrozil, triclosan, and ibuprofen) in environmental water samples...
August 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28808208/effects-of-bisphenol-compounds-on-the-growth-and-epithelial-mesenchymal-transition-of-mcf-7-cv-human-breast-cancer-cells
#4
Ji-Youn Kim, Ho-Gyu Choi, Hae-Miru Lee, Geum-A Lee, Kyung-A Hwang, Kyung-Chul Choi
Bisphenol-A (BPA) has been considered as an endocrine disrupting chemical (EDC) because it can exert estrogenic properties. For bisphenol-S (BPS) and bisphenol-F (BPF) that are BPA analogs and substitutes, their risk to estrogen-dependent cancer has been reported rarely compared with the numerous cases of BPA. In this study, we examined whether BPA, BPS, and BPF can lead to the proliferation, migration, and epithelial mesenchymal transition (EMT) of MCF-7 clonal variant (MCF-7 CV) breast cancer cells expressing estrogen receptors (ERs)...
July 13, 2017: Journal of Biomedical Research
https://www.readbyqxmd.com/read/28806546/parental-exposure-to-bisphenol-a-and-its-analogs-influences-zebrafish-offspring-immunity
#5
Xing Dong, Zhen Zhang, Shunlong Meng, Chenyuan Pan, Ming Yang, Xiangyang Wu, Liuqing Yang, Hai Xu
Transgenerational effects of environmental pollutants on humans and animals are complex. Thus, we used zebrafish to evaluate the effects of parental whole-life cycle exposure to bisphenol A and its analogs (bisphenol S and F) on offspring innate immunity. At adulthood, offspring were examined with/without continued chemicals treatment until 72h post-fertilization (hpf). To measure offspring immune function, larvae at 72 hpf were expose for 24h with/without the viral mimic polyinosinic-cytidylic acid (Poly I:C) or the bacterial mimic Pam3Cys-Ser-Lys4 (PAM3CSK4)...
August 11, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28806056/self-generation-of-reactive-oxygen-species-on-crystalline-agbio3-for-the-oxidative-remediation-of-organic-pollutants
#6
Jianyu Gong, Chung-Seop Lee, Eun-Ju Kim, Jae-Hwan Kim, Woojin Lee, Yoon-Seok Chang
In this study, we synthesized a novel perovskite nanomaterial consisting of AgBiO3 nanoparticles (NPs) via an ion-exchange method for remediation of polluted environments. The AgBiO3 NPs could self-produce significant amounts of reactive oxygen species (ROS) without light illumination or any other additional oxidant due to the controllable release of lattice oxygen from the crystalline AgBiO3, resulting in the formation of ROS somehow. The self-produced 1O2, O2•- and •OH were confirmed by electron spin resonance spectroscopy using a spin trap technique...
August 14, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28805263/optical-limiting-properties-of-3-5-dithienylenevinylene-bodipy-dyes-at-532-nm
#7
Jessica Harris, Lizhi Gai, Gugu Kubheka, John Mack, Tebello Nyokong, Zhen Shen
The optical limiting properties of a series of near infrared absorbing 3,5-dithienylenevinylene BODIPY dyes (1-3) that contain donor and acceptor moieties in their π-conjugation systems were studied by using the z-scan technique at 532 nm in the nanosecond pulse range. A strong reverse saturable absorption RSA response was observed when the compounds are embedded into poly(bisphenol carbonate A) polymer thin films, which demonstrates that BODIPY dyes with this type of structure are suitable for use in optical limiting applications...
August 14, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28805116/bisphenol-a-and-adverse-pregnancy-outcomes-a-systematic-review-of-the-literature
#8
Vasilios Pergialiotis, Paraskevi Kotrogianni, Evangelos Christopoulos-Timogiannakis, Diamanto Koutaki, Georgios Daskalakis, Nikolaos Papantoniou
PURPOSE: Bisphenol A is a chemical compound related to adverse maternal and neonatal outcomes. The purpose of the present systematic review is to summarize current knowledge in the field. MATERIALS AND METHODS: We systematically searched the Medline (1966-2017), Scopus (2004-2017), Clinicaltrials.gov (2008-2017), Cochrane Central Register of Controlled Trials CENTRAL (1999-2017) databases. RESULTS: Thirty-five studies were included in the present systematic review...
August 14, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28802977/adsorption-and-coadsorption-mechanisms-of-cr-vi-and-organic-contaminants-on-h3po4-treated-biochar
#9
Nan Zhao, Chuanfang Zhao, Yizhong Lv, Weifang Zhang, Yuguo Du, Zhengping Hao, Jing Zhang
The study of simultaneous removal of heavy metals and organic contaminants has practical applications due to the coexistence of complex pollutants in the wastewater or soil. In this work, biochar was prepared to study the removal efficiencies of Cr(VI), naphthalene (NAP) and bisphenol A (BPA) in the single or mixed systems. H3PO4-treated biochar presented a much higher adsorption capacity of the pollutants than the untreated biochar and also showed a high resistance to coexisting salts. The maximum adsorption capacities for Cr(VI) and BPA were 116...
August 7, 2017: Chemosphere
https://www.readbyqxmd.com/read/28802889/ameliorative-effect-of-propolis-supplementation-in-alleviating-bisphenol-a-toxicity-growth-performance-biochemical-variables-and-oxidative-stress-biomarkers-of-nile-tilapia-oreochromis-niloticus-l-fingerlings
#10
Heba S Hamed, Mohsen Abdel-Tawwab
Bisphenol-A (BPA) is one of the important pollutants in aquatic ecosystems and its detrimental effects on fish have a great concern. Propolis is a natural immune-stimulant that has various biological and pharmacological activities. Thus, its capability to alleviate the toxic effect of BPA on Nile tilapia, Oreochromis niloticus (L.) was assessed in a study based on a 2 × 2 factorial design with two levels of ethanolic extract of propolis (EEP) and two waterborne BPA concentrations in triplicates. Fish (33.9 ± 0...
August 9, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/28801775/plasticizers-and-bisphenol-a-in-packaged-foods-sold-in-the-tunisian-markets-study-of-their-acute-in-vivo-toxicity-and-their-environmental-fate
#11
Asma Beltifa, Anouar Feriani, Monia Machreki, Asma Ghorbel, Lakhdar Ghazouani, Giuseppa Di Bella, Joris Van Loco, Tim Reyns, Hedi Ben Mansour
Today, processed and packaged foods are considered as among the major sources of human exposure to plasticizers and bisphenol which migrate from plastic packing. In the present study, a wide range of food products sold on the Tunisian market such as grain and grain products, milk and dairy products, fats and oil, drink, fish, and sweets have been analyzed firstly in order to identify the presence of phthalates and bisphenol. Then, the identified chemical molecules were studied for their environmental fate and tested in vivo for its toxicity in mice models...
August 12, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28801100/neuroendocrine-disruption-in-animal-models-due-to-exposure-to-bisphenol-a-analogues
#12
REVIEW
Cheryl S Rosenfeld
Animal and human studies provide evidence that exposure to the endocrine disrupting chemical (EDC), bisphenol A (BPA), can lead to neurobehavioral disorders. Consequently, there is an impetus to identify safer alternatives to BPA. Three bisphenol compounds proposed as potential safer alternatives to BPA are bisphenol S (BPS), bisphenol F (BPF), and bisphenol AF (BPAF). However, it is not clear whether these other compounds are safer in terms of inducing less endocrine disrupting effects in animals and humans who are now increasingly coming into contact with these BPA-substitutes...
August 8, 2017: Frontiers in Neuroendocrinology
https://www.readbyqxmd.com/read/28800472/phthalate-and-bisphenol-a-exposure-during-in-utero-windows-of-susceptibility-in-relation-to-reproductive-hormones-and-pubertal-development-in-girls
#13
Deborah J Watkins, Brisa N Sánchez, Martha Maria Téllez-Rojo, Joyce M Lee, Adriana Mercado-García, Clara Blank-Goldenberg, Karen E Peterson, John D Meeker
BACKGROUND: Over the past several decades, the age of pubertal onset in girls has shifted downward worldwide. As early pubertal onset is associated with increased risky behavior and psychological issues during adolescence and cardiometabolic disease and cancer in adulthood, this is an important public health concern. Exposure to endocrine disrupting chemicals during critical windows of in utero development may play a role in this trend. Our objective was to investigate trimester-specific phthalate and BPA exposure in relation to pubertal development among girls in the Early Life Exposure in Mexico to Environmental Toxicants (ELEMENT) birth cohort...
August 8, 2017: Environmental Research
https://www.readbyqxmd.com/read/28799939/one-step-hydrothermal-synthesis-of-ctab-modified-sio2-for-removal-of-bisphenol-a
#14
Yefei Zhang, Chao Liu, Lijun Luo, Yingying Shi, Yu Chen, Shan Wang, Longchun Bian, Fengzhi Jiang
A stable SiO2 material marked as CTAB-Ms(x) was synthesized by a novel sol-gel method. It was modified with hexadecyl trimethyl ammonium bromide (CTAB), which resulted in high adsorption capacity. Its microstructure and surface functional groups were characterized by scanning electron microscope, transmission electron microscope and Fourier transform infrared. The results showed that CTAB-Ms(x) had a core/shell structure in which the core was a CTAB micelle and the shell was SiO2. The prepared material was applied to adsorb bisphenol A (BPA)...
August 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/28796629/hepatic-lipid-accumulation-and-nrf2-expression-following-perinatal-and-peripubertal-exposure-to-bisphenol-a-in-a-mouse-model-of-nonalcoholic-liver-disease
#15
Prajakta C Shimpi, Vijay R More, Maneesha Paranjpe, Ajay C Donepudi, Jaclyn M Goodrich, Dana C Dolinoy, Beverly Rubin, Angela L Slitt
BACKGROUND: Exposure to chemicals during critical windows of development may re-program liver for increased risk of nonalcoholic fatty liver disease (NAFLD). Bisphenol A (BPA), a plastics component, has been described to impart adverse effects during gestational and lactational exposure. Our work has pointed to nuclear factor E2-related factor 2 (Nrf2) being a modulator of hepatic lipid accumulation in models of NAFLD. OBJECTIVES: To determine if chemical exposure can prime liver for steatosis via modulation of NRF2 and epigenetic mechanisms...
August 4, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28794440/vitellogenin-induction-in-caudal-fin-of-guppy-poecilia-reticulata-as-a-less-invasive-and-sensitive-biomarker-for-environmental-estrogens
#16
Jun Wang, Shuwei Ma, Zhenzhong Zhang, Mingyi Zheng, Yifei Dong, Shaoguo Ru
Guppy (Poecilia reticulata) is an ideal model for studying environmental estrogens, and its large caudal fin has a high capacity to regenerate. This study analyzed the feasibility of caudal fin for detecting vitellogenin (Vtg), the most commonly used biomarker of environmental estrogens. Firstly, a sandwich ELISA for guppy Vtg was developed using purified lipovitellin and its antibody and it had a working range of 7.8-1000 ng/mL and detection limit of 3.1 ng/mL. The ELISA was used to detect tissue distribution of Vtg...
August 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28793400/enhanced-uptake-of-bpa-in-the-presence-of-nanoplastics-can-lead-to-neurotoxic-effects-in-adult-zebrafish
#17
Qiqing Chen, Daqiang Yin, Yunlu Jia, Sabrina Schiwy, Jessica Legradi, Shouye Yang, Henner Hollert
Plastic particles have been proven to be abundant in the aquatic environment, raising concerns about their potential toxic effects. In the present study, we determined the bioaccumulation potential of bisphenol A (BPA) in adult zebrafish (Danio rerio) in the absence and presence of nano-sized plastic particles (nanoplastics, NPPs). Results show that BPA can accumulate in the viscera, gill, head and muscle of zebrafish with 85, 43, 20, and 3μg/g ww after 1d exposure. NPPs were also found to accumulate in different tissues of the fish...
August 5, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28792685/sensitive-determination-of-typical-phenols-in-environmental-water-samples-by-magnetic-solid-phase-extraction-with-polyaniline-sio2-fe-as-the-adsorbents-before-hplc
#18
Qingxiang Zhou, Yongyong Yuan, Yalin Wu, Yongli Liu
A novel magnetic core-shell material polyaniline@SiO2@Fe (PANI@SiO2@Fe) has been successfully synthesized and investigated as an effective adsorbent for the magnetic solid-phase extraction of typical endocrine disrupting compounds such as bisphenol A, tetrabromobisphenol A and 4-nonylphenol from water samples. The morphology of the as-prepared PANI@SiO2@Fe was characterized by transmission electron microscopy and X-ray diffraction. The main parameters that influenced the enrichment performance such as the kind of eluent, amount of adsorbent, volume of eluent, adsorption time, elution time, ionic strength, pH, concentration of humic acid and sample volume were investigated...
August 9, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28792119/sufex-based-polysulfonate-formation-from-ethenesulfonyl-fluoride-amine-adducts
#19
Hua Wang, Feng Zhou, Gerui Ren, Qinheng Zheng, Hongli Chen, Bing Gao, Liana Klivansky, Yi Liu, Bin Wu, Qingfeng Xu, Jianmei Lu, K Barry Sharpless, Peng Wu
The SuFEx-based polycondensation between bisalkylsulfonyl fluorides (AA monomers) and bisphenol bis(t-butyldimethylsilyl) ethers (BB monomers) using [Ph3 P=N-PPh3 ](+) [HF2 ](-) as the catalyst is described. The AA monomers were prepared via the highly reliable Michael addition of ethenesulfonyl fluoride and amines/anilines while the BB monomers were obtained from silylation of bisphenols by t-butyldimethylsilyl chloride. With these reactions, a remarkable diversity of monomeric building blocks was achieved by exploiting readily available amines, anilines, and bisphenols as starting materials...
May 18, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28790390/involvement-of-insulin-signaling-disturbances-in-bisphenol-a-induced-alzheimer-s-disease-like-neurotoxicity
#20
Tingwei Wang, Cuiwei Xie, Pengfei Yu, Fangfang Fang, Jingying Zhu, Jie Cheng, Aihua Gu, Jun Wang, Hang Xiao
Bisphenol A (BPA), a member of the environmental endocrine disruptors (EDCs), has recently received increased attention because of its effects on brain insulin resistance. Available data have indicated that brain insulin resistance may contribute to neurodegenerative diseases. However, the associated mechanisms that underlie BPA-induced brain-related outcomes remain largely unknown. In the present study, we identified significant insulin signaling disturbances in the SH-SY5Y cell line that were mediated by BPA, including the inhibition of physiological p-IR Tyr1355 tyrosine, p-IRS1 tyrosine 896, p-AKT serine 473 and p-GSK3α/β serine 21/9 phosphorylation, as well as the enhancement of IRS1 Ser307 phosphorylation; these effects were clearly attenuated by insulin and rosiglitazone...
August 8, 2017: Scientific Reports
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