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Alzbeta Bujnakova Mlynarcikova, Sona Scsukova
In the present study, we aimed to examine effects of different concentrations of the endocrine disruptor Bisphenol A (BPA; 1 nM, 1 μM, 100 μM) and the flavonoid fisetin (1, 10, 25, 50 μM), individually and in combinations, on steroidogenic function of porcine ovarian granulosa cells (GCs) represented by progesterone production. We confirmed that BPA inhibited progesterone production by GCs at the highest concentration. Fisetin reduced gonadotropin-stimulated progesterone synthesis dose-dependently, and in this manner, fisetin impaired progesterone production when added to BPA-treated GCs...
March 2, 2018: Environmental Toxicology and Pharmacology
Gibeom Kwon, Sungho Ghil
Warm temperature acclimation-associated 65-kDa protein (Wap65) is known to respond to elevated water temperatures and the corresponding gene from several fish species has been cloned. Expression of Wap65 gene is induced by various physiological stresses, such as increase in water temperature, immune response and heavy metal exposure. Two isolated Wap65 genes, Wap65-1 and Wap65-2, display distinct tissue distribution and physiological functions despite high sequence homology. In a previous study, we identified the Wap65-1 gene (kmWap65-1) from Kumgang fat minnow, Rhynchocypris kumgangensis, a small freshwater fish endemic to Korea...
March 15, 2018: Journal of Experimental Zoology. Part A, Ecological and Integrative Physiology
Kelly A Campen, Katherine M Kucharczyk, Benjamin Bogin, Julie M Ehrlich, Catherine M H Combelles
STUDY QUESTION: What are the effects of exposure to bisphenol A (BPA) or bisphenol S (BPS) during IVM on bovine oocyte maturation, spindle morphology and chromosome alignment? SUMMARY ANSWER: Exposure to BPA or BPS during IVM resulted in increased spindle abnormalities and chromosome misalignment, even at very low concentrations. WHAT IS KNOWN ALREADY: BPA is an endocrine disrupting chemical that alters oocyte maturation, spindle morphology and chromosome alignment in a range of species...
March 12, 2018: Human Reproduction
Martin Eckardt, Annemarie Greb, Thomas J Simat
Polyphenylsulfone (PPSU) is a new material for the production of baby bottles. PPSU is a polyether plastic formally composed of bisphenol S (BPS) and 4,4'-dihydroxybiphenyl (DHBP), which both have slight endocrine activities in in-vitro-tests. So far, little is known about the presence and the release of potentially hazardous substances from PPSU baby bottles. In our present study, we present a three step approach for the analysis of PPSU starting with polymer characterization in terms of chemical structure, total oligomer content and hydrolytic stability...
March 14, 2018: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
Piotr Pander, Rachel Bulmer, Ross Martinscroft, Stuart Thompson, Frank W Lewis, Thomas J Penfold, Fernando B Dias, Valery N Kozhevnikov
This article describes a convenient method for the synthesis of ONNO-type tetradentate 6,6'-bis(2-phenoxy)-2,2'-bipyridine (bipyridine bisphenolate, BpyBph) ligands and their platinum(II) complexes. The methodology includes the synthesis of 1,2,4-triazine precursors followed by their transformation to functionalized pyridines by the Boger reaction. Two complementary routes employing 3,3'- and 5,5'-bis-triazines allow a modification of the central pyridine rings in different positions, which was exemplified by the introduction of cyclopentene rings...
March 14, 2018: Inorganic Chemistry
Jingwei He, Sufyan Garoushi, Pekka K Vallittu, Lippo Lassila
This study was conducted to determine whether novel experimental low-shrinkage dimethacrylate co-monomers could provide low polymerization shrinkage composites without sacrifice to degree of conversion, and mechanical properties of the composites. Experimental composites were prepared by mixing 28.6 wt% of bisphenol-A-glycidyl dimethacrylate based resin matrix ( bis -GMA) with various weight-fractions of co-monomers; tricyclo decanedimethanol dacrylate (SR833s) and isobornyl acrylate (IBOA) to 71.4 wt% of particulate-fillers...
2018: Acta Biomaterialia Odontologica Scandinavica
Rim Mtibaà, Dario Rafael Olicón-Hernández, Clementina Pozo, Moncef Nasri, Tahar Mechichi, Jesus González, Elisabet Aranda
Four different laccase-producing strains were isolated from arid soils and used for bisphenol A (BPA) degradation. These strains were identified as Chaetomium strumarium G5I, Thielavia arenaria CH9, Thielavia arenaria HJ22 and Thielavia arenaria SM1(III) by internal transcribed spacer 5.8 S rDNA analysis. Residual BPA was evaluated by HPLC analysis during 48 h of incubation. A complete removal of BPA was observed by the whole cell fungal cultures within different times, depending on each strain. C. strumarium G5I was the most efficient degrader, showing 100% of removal within 8 h of incubation...
March 13, 2018: Ecotoxicology and Environmental Safety
Charles Staples, Nelly van der Hoeven, Kathryn Clark, Ellen Mihaich, Jan Woelz, Steven Hentges
Concentrations of bisphenol A (BPA) in North American and European fresh and marine surface waters and sediments were analyzed to quantify environmental levels and evaluate trends over the years 1996-2014. In North American surface water and sediment, 68% of 1030 weighted observations were below a detection limit (varied widely between studies). In Europe, 33% of 5057 weighted observations were below a detection limit. In North America and Europe, 50th percentile concentrations were 0.005 μg L-1 and 0.029 μg L-1 in freshwater and 0...
March 1, 2018: Chemosphere
Giacomo Russo, Antonella Capuozzo, Francesco Barbato, Carlo Irace, Rita Santamaria, Lucia Grumetto
Bisphenol A (BPA) is a chemical used in numerous industrial applications. Due to its well ascertained toxicity as endocrine disruptor, industries have started to replace it with other bisphenols whose alleged greater safety is scarcely supported by literature studies. In this study, the toxicity of seven BPA analogues was evaluated using both in silico and in vitro techniques, as compared to BPA toxicity. Furthermore, their affinity indexes for phospholipids (i.e. phospholipophilicity) were determined by immobilized artificial membrane liquid chromatography (IAM-LC) and possible relationships with in vitro toxic activity were also investigated...
March 5, 2018: Chemosphere
Sebastian Mas, Enrique Bosch-Panadero, Pedro Abaigar, Vanesa Camarero, Ignacio Mahillo, Esther Civantos, Didier Sanchez-Ospina, Alberto Ruiz-Priego, Jesus Egido, Alberto Ortiz, Emilio González-Parra
INTRODUCTION: Bisphenol A (BPA) is an ubiquitous environmental toxin that is also found in dialyzers. Online hemodiafiltration (OL-HDF) more efficiently clears high molecular weight molecules, and this may improve BPA clearance. However, the BPA contents of dialysis membranes may be a source of BPA loading during OL-HDF. METHODS: A prospective study assessed plasma BPA levels in OL-HDF patients using BPA-free (polynephron) or BPA-containing (polysulfone) dialyzers in a crossover design with two arms, after a run-in OL-HDF period of at least 6 months with the same membrane: 31 patients on polynephron at baseline were switched to polysulfone membranes for 3 months (polynephron-to-polysulfone) and 29 patients on polysulfone were switched to polynephron for 3 months (polysulfone-to-polynephron)...
2018: PloS One
Ashish Kumar, Christian Schuerings, Suneel Kumar, Ajay Kumar, Venkata Krishnan
A novel graphitic carbon nitride (g-C3 N4 )-CaTiO3 (CTCN) organic-inorganic heterojunction photocatalyst was synthesized by a facile mixing method, resulting in the deposition of CaTiO3 (CT) nanoflakes onto the surface of g-C3 N4 nanosheets. The photocatalytic activity of the as-synthesized heterojunction (along with the controls) was evaluated by studying the degradation of an aqueous solution of rhodamine B (RhB) under UV, visible and natural sunlight irradiation. The CTCN heterojunction with 1:1 ratio of g-C3 N4 /CT showed the highest photocatalytic activity under sunlight irradiation and was also demonstrated to be effective for the degradation of a colorless, non-photosensitizing pollutant, bisphenol A (BPA)...
2018: Beilstein Journal of Nanotechnology
Yousif A Al Dulaijan, Lei Cheng, Michael D Weir, Mary Anne S Melo, Huaibing Liu, Thomas W Oates, Lin Wang, Hockin H K Xu
OBJECTIVE: Rechargeable calcium phosphate (CaP) composites were developed recently. However, none of the rechargeable CaP composites was antibacterial. The objectives of this study were to develop the first rechargeable CaP composite that was antibacterial, and to investigate the effects of adding dimethylaminohexadecyl methacrylate (DMAHDM) into rechargeable CaP composite on ion rechargeability and re-release as well as biofilm properties. METHODS: DMAHDM was synthesized via a Menschutkin reaction...
March 8, 2018: Journal of Dentistry
SriDurgaDevi Kolla, Mary Morcos, Brian Martin, Laura N Vandenberg
Throughout life, mammary tissue is strongly influenced by hormones. Scientists have hypothesized that synthetic chemicals with hormonal activities could disrupt mammary gland development and contribute to breast diseases and dysfunction. Bisphenol S (BPS) is an estrogenic compound used in many consumer products. In this study, CD-1 mice were exposed to BPS (2 or 200 μg/kg/day) during pregnancy and lactation. Mice exposed to 0.01 or 1 μg/kg/day ethinyl estradiol (EE2), a pharmaceutical estrogen, were also evaluated...
March 8, 2018: Reproductive Toxicology
Johanna R Rochester, Ashley L Bolden, Carol F Kwiatkowski
BACKGROUND: Attention-deficit hyperactivity disorder (ADHD) has increased in prevalence in the past decade. Studies attempting to identify a specific genetic component have not been able to account for much of the heritability of ADHD, indicating there may be gene-environment interactions underlying the disorder, including early exposure to environmental chemicals. Based on several relevant studies, we chose to examine bisphenol A (BPA) as a possible contributor to ADHD in humans. BPA is a widespread environmental chemical that has been shown to disrupt neurodevelopment in rodents and humans...
March 3, 2018: Environment International
Amrit Kaur Sakhi, Azemira Sabaredzovic, Eleni Papadopoulou, Enrique Cequier, Cathrine Thomsen
BACKGROUND: Exposure to environmental phenols including parabens, bisphenols (BPs), oxybenzone/benzophenone-3 (BP-3) and triclosan (TCS) is ubiquitous. Due to evidence of their estrogenic activity, they have been considered as chemicals of concern. The exposure of the Norwegian population to these compounds is presently unknown. AIMS: To measure urinary levels of twelve different environmental phenols including four emerging bisphenols: S, F, B and AF (abbreviated as BPS, BPF, BPB and BPAF, respectively) in a healthy Norwegian population...
March 7, 2018: Environment International
Zhaofeng Chang, Luping Tian, Min Wu, Xudong Dong, Juan Peng, Bo Pan
Biochar function in soil is based on properties such as sorption characteristics, and these are expected to change throughout the life cycle of the biochar. Because biochar particles cannot easily be separated from soil particles, this change is seldom investigated. Biochar-related molecular markers, such as benzene polycarboxylic acids (BPCAs) are promising tools for studying the properties of biochars in complex environmental matrices. In this study, biochars were derived from corn straw and pine wood sawdust at 200-500 °C, and their aging was simulated with NaClO...
March 7, 2018: Environmental Pollution
Magdalena Noszczyńska, Zofia Piotrowska-Seget
Numerous data indicate that most of bisphenols (BPs) are endocrine disrupters and exhibit cytotoxicity, neurotoxicity, genotoxicity and reproductive toxicity against vertebrates. Nevertheless, they are widely applied in material production what result in their ubiquitous occurrence in ecosystems. While BPA is the most frequently detected in environment, BPAF, BPF and BPS are also often found. Ecosystem particularly exposed to BPs pollution is industrial and municipal wastewater being a common source of BPA in river waters...
February 28, 2018: Chemosphere
Lanlan Chen, Yu Zhao, Linchao Li, Lubin Xie, Xianwu Chen, Jianpeng Liu, Xiaoheng Li, Lixu Jin, Xingwang Li, Ren-Shan Ge
Bisphenol A (BPA) is widely used in consumer products and a potential endocrine disruptor linked with sexual precocity. However, its action and underlying mechanisms on male sexual maturation is unclear. In the present study, we used a unique in vivo ethane dimethane sulfonate (EDS)-induced Leydig cell regeneration model that mimics the pubertal development of Leydig cells and an in vitro stem Leydig cell differentiation model to examine the roles of BPA in Leydig cell development in rats. Intratesticular exposure to doses (100 and 1000 pmol/testis) of BPA from post-EDS day 14-28 stimulated Leydig cell developmental regeneration process by increasing serum testosterone level and Leydig cell-specific gene (Lhcgr, Star, Cyp11a1, Hsd3b1, Cyp17a1, Hsd17b3, and Hsd11b1) and their protein expression levels...
March 7, 2018: Molecular and Cellular Endocrinology
Yu-Ting Li, Ying Liang, Yue-Nan Li, Xing-Kai Che, Shi-Jie Zhao, Zi-Shan Zhang, Hui-Yuan Gao
Bisphenol A (BPA), a widely distributed pollutant, suppresses photosynthesis in leaves. In previous studies on higher plants, the plants were treated by BPA through irrigation to root. This method cannot distinguish whether the BPA directly suppresses photosynthesis in leaves, or indirectly influences photosynthesis through affecting the function of root. Here, only the leaves but not the roots of cucumber were infiltrated with BPA solution. The photosystem II and I (PSII, PSI) were insensitive to BPA under darkness...
March 9, 2018: Scientific Reports
Guoyun Wu, Dan Song, Quanwei Wei, Jun Xing, Xiaoli Shi, Fangxiong Shi
Melatonin plays a crucial role in the amelioration of reproductive toxicity induced by endocrine-disrupting chemicals. However, very few studies have investigated the mitigating effects of melatonin on BPA-induced dysfunction in porcine granulosa cells. In the present study, primary granulosa cells were cultured in serum-low conditions with bisphenol A (BPA) (10 μM) with or without melatonin (100 μM), followed by evaluation of estradiol synthesis and cell proliferation. Our results showed that BPA significantly increased estradiol concentration and granulosa cell proliferation...
February 24, 2018: Animal Reproduction Science
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