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https://www.readbyqxmd.com/read/28433925/low-dose-pollutant-mixture-triggers-metabolic-disturbances-in-female-mice-leading-to-common-and-specific-features-as-compared-to-a-high-fat-diet
#1
Emmanuel Labaronne, Claudie Pinteur, Nathalie Vega, Sandra Pesenti, Benoit Julien, Emmanuelle Meugnier-Fouilloux, Hubert Vidal, Danielle Naville, Brigitte Le Magueresse-Battistoni
Environmental pollutants are potential etiologic factors of obesity and diabetes that reach epidemic proportions worldwide. However, it is important to determine if pollutants could exert metabolic defects without directly inducing obesity. The metabolic disturbances triggered in nonobese mice lifelong exposed to a mixture of low-dose pollutants (2,3,7,8-tetrachlorodibenzo-p-dioxine, polychlorinated biphenyl 153, diethylhexyl-phthalate, and bisphenol A) were compared with changes provoked by a high-fat high-sucrose (HFHS) diet not containing the pollutant mixture...
April 8, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28433178/preparation-and-characterization-of-biodegradable-nanocomposites-derived-from-carboxymethyl-cellulose-and-hydroxyapatite
#2
K Azzaoui, E Mejdoubi, A Lamhamdi, S Jodeh, O Hamed, M Berrabah, S Jerdioui, R Salghi, N Akartasse, A Errich, Á Ríos, M Zougagh
Development of a cost-effective technology for extraction and quantification of carcinogenic and toxic organic materials which are widely used in the industry are critical to humans. Membrane technology received much attention and has already been widely used in this area. In this work, we offer a newly developed bio-based nanocomposite membrane for removal of bisphenol-A (BPA) from water. Three natural components hydroxyapatite (HAp), carboxymethyl cellulose and lysine as a diluent were used for making the bio-based membrane...
July 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28428763/adhd-lifestyles-and-comorbidities-a-call-for-an-holistic-perspective-from-medical-to-societal-intervening-factors
#3
REVIEW
Simon Weissenberger, Radek Ptacek, Martina Klicperova-Baker, Andreja Erman, Katerina Schonova, Jiri Raboch, Michal Goetz
The review examines Attention Deficit Hyperactivity Disorder (ADHD in its Child and Adult form) and its various presentations (Hyperactive Impulsive, Inattentive, and Combined) with a particular focus on environmental (incl. social factors), lifestyles and comorbidities. It is argued that ADHD is best understood in a holistic and interactive context and a vast empirical literature is presented to illustrate the point: Environmental factors include stress in general as well as exposure to toxins (phthalates, bisphenol A)...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28426875/bisphenol-a-activates-egfr-and-erk-promoting-proliferation-tumor-spheroid-formation-and-resistance-to-egfr-pathway-inhibition-in-estrogen-receptor-negative-inflammatory-breast-cancer-cells
#4
Scott J Sauer, Michael Tarpley, Imran Shah, Akshay V Save, H Kim Lyerly, Steven R Patierno, Kevin P Williams, Gayathri R Devi
Emerging evidence from epidemiological studies suggests a link between environmental chemical exposure and progression of aggressive breast cancer subtypes. Of all clinically distinct types of breast cancers, the most lethal phenotypic variant is inflammatory breast cancer (IBC). Overexpression of epidermal growth factor receptors (EGFR/HER2) along with estrogen receptor (ER) negativity is common in IBC tumor cells, which instead of a solid mass present as rapidly proliferating diffuse tumor cell clusters. Our previous studies have demonstrated a role of an adaptive response of increased antioxidants in acquired resistance to EGFR-targeting drugs in IBC...
March 1, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/28416215/stir-bar-sorptive-extraction-and-liquid-chromatography-tandem-mass-spectrometry-determination-of-polar-and-non-polar-emerging-and-priority-pollutants-in-environmental-waters
#5
Irene Aparicio, Julia Martín, Juan Luis Santos, José Luis Malvar, Esteban Alonso
An analytical method based on stir bar sorptive extraction (SBSE) was developed and validated for the determination of environmental concern pollutants in environmental waters by liquid chromatography-tandem mass spectrometry (LC-MS/MS). Target compounds include six water and oil repellents (perfluorinated compounds), four preservatives (butylated hydroxytoluene and three parabens), two plasticizers (bisphenol A and di(2-ethylhexyl)phthalate), seven surfactants (four linear alkylbenzene sulfonates, nonylphenol and two nonylphenol ethoxylates), a flame retardant (hexabromocyclododecane), four hormones, fourteen pharmaceutical compounds, an UV-filter (2-ethylhexyl 4-methoxycinnamate) and nine pesticides...
April 7, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28411819/an-electrochemical-bisphenol-a-sensor-based-on-one-step-electrochemical-reduction-of-cuprous-oxide-wrapped-graphene-oxide-nanoparticles-modified-electrode
#6
Rongguang Shi, Jing Liang, Zongshan Zhao, Aifeng Liu, Yong Tian
Bisphenol A (BPA), as an important industrial material, has been widespread concerned in recent years as its endocrine disrupting effect. This study reported a novel bisphenol A sensor via a facile one step electrochemical reduction of graphene oxide (rGO) and cuprous oxide (Cu2O) nanocomposite modified glassy carbon electrodes. The characterization of the fabricated sensor was performed by scanning electron microscopy and X-ray spectroscopy. The prepared Cu2O-rGO electrode presented fast response, high sensitivity and low background current...
July 1, 2017: Talanta
https://www.readbyqxmd.com/read/28411541/spectroscopic-and-molecular-modeling-approaches-to-investigate-the-interaction-of-bisphenol-a-bisphenol-f-and-their-diglycidyl-ethers-with-ppar%C3%AE
#7
Jie Zhang, Tiehua Zhang, Tianzhu Guan, Ping Ruan, Dayong Ren, Weichang Dai, Hansong Yu, Tiezhu Li
A fluorescence polarization (FP) assay for the simultaneous determination of bisphenol A (BPA), bisphenol F (BPF), bisphenol A diglycidyl ether (BADGE) and bisphenol F diglycidyl ether (BFDGE) was developed. The method was based on the competition between bisphenols (BPs) and fluorescein-labeled dexamethasone derivative (Dex-fl) for mouse peroxisome proliferator-activated receptor α ligand binding domain (mPPARα-LBD). A recombinant soluble protein derivative mPPARα-LBD* was prepared, then in vitro binding of 4 BPs to mPPARα-LBD* was investigated...
April 9, 2017: Chemosphere
https://www.readbyqxmd.com/read/28411468/nine-co-localized-cytochrome-p450-genes-of-the-cyp2n-cyp2ad-and-cyp2p-gene-families-in-the-mangrove-killifish-kryptolebias-marmoratus-genome-identification-and-expression-in-response-to-b-%C3%AE-p-bpa-op-and-np
#8
Jayesh Puthumana, Bo-Mi Kim, Chang-Bum Jeong, Duck-Hyun Kim, Hye-Min Kang, Jee-Hyun Jung, Il-Chan Kim, Un-Ki Hwang, Jae-Seong Lee
The CYP2 genes are the largest and most diverse cytochrome P450 (CYP) subfamily in vertebrates. We have identified nine co-localized CYP2 genes (∼55kb) in a new cluster in the genome of the highly resilient ecotoxicological fish model Kryptolebias marmoratus. Molecular characterization, temporal and tissue-specific expression pattern, and response to xenobiotics of these genes were examined. The CYP2 gene clusters were characterized and designated CYP2N22-23, CYP2AD12, and CYP2P16-20. Gene synteny analysis confirmed that the cluster in K...
March 31, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/28410473/thyroid-hormone-parameters-during-pregnancy-in-relation-to-urinary-bisphenol-a-concentrations-a-repeated-measures-study
#9
Max T Aung, Lauren E Johns, Kelly K Ferguson, Bhramar Mukherjee, Thomas F McElrath, John D Meeker
BACKGROUND: Maternal supply of thyroid hormones during pregnancy serves a critical role in fetal development. Although animal and in vitro studies provide evidence for thyroid hormone disruption as a result of bisphenol A (BPA) exposure, there is still a lack of evidence in human studies, particularly in the context of pregnancy. OBJECTIVES: We aimed to explore the associations between urinary BPA concentrations and plasma thyroid hormone parameters during gestation in pregnant women, and also investigated potential windows of vulnerability during gestation...
April 11, 2017: Environment International
https://www.readbyqxmd.com/read/28407592/different-effects-of-bisphenol-a-and-its-halogenated-derivatives-on-the-reproduction-and-development-of-oryzias-melastigma-under-environmentally-relevant-doses
#10
Qiansheng Huang, Yajie Chen, Lifeng Lin, Yiyao Liu, Yulang Chi, Yi Lin, Guozhu Ye, Huiming Zhu, Sijun Dong
Bisphenol A (BPA) and its halogenated compounds (H-BPAs) are widely detected in the environmental media and organisms. However, their toxicological effects, especially chronic exposure at low doses, have not been fully compared. In this study, the effects of BPA and H-BPAs on the reproduction and development of Oryzias melastigma were systematically assessed and compared at various developmental stages. BPA and its derivatives tetrabromobisphenol A (TBBPA) and tetrachlorobisphenol A (TCBPA) elicited the acceleration of embryonic heartbeat...
April 10, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28407500/in-vitro-and-in-vivo-estrogenic-activity-of-bpa-bpf-and-bps-in-zebrafish-specific-assays
#11
Vincent Le Fol, Selim Aït-Aïssa, Manoj Sonavane, Jean-Marc Porcher, Patrick Balaguer, Jean-Pierre Cravedi, Daniel Zalko, François Brion
Bisphenol A (BPA) is a widely used chemical that has been extensively studied as an endocrine-disrupting chemical (EDC). Other bisphenols sharing close structural features with BPA, are increasingly being used as alternatives, increasing the need to assess associated hazards to the endocrine system. In the present study, the estrogenic activity of BPA, bisphenol S (BPS) and bisphenol F (BPF) was assessed by using a combination of zebrafish-specific mechanism-based in vitro and in vivo assays. The three bisphenols were found to efficiently transactivate all zebrafish estrogen receptor (zfER) subtypes in zebrafish hepatic reporter cell lines (ZELH-zfERs)...
April 11, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28406523/exposure-to-extrinsic-stressors-social-defeat-or-bisphenol-a-eliminates-sex-differences-in-dna-methyltransferase-expression-in-the-amygdala
#12
Emily C Wright, Sarah A Johnson, Rebecca Hao, Alex S Kowalczyk, Gian D Greenberg, Evelyn Ordoñes Sanchez, Abigail Laman-Maharg, Brian C Trainor, Cheryl S Rosenfeld
Chemical and psychological stressors can exert long lasting changes in brain function and behavior. Changes in DNA methylation have been shown to be an important mechanism mediating long lasting changes in neural function and behavior, especially for anxiety-like or stress responses. Here we examined the effects of either a social or chemical stressor on DNA methyltransferase (DNMT) gene expression in the amygdala, an important brain region modulating stress responses and anxiety. In adult California mice (Peromyscus californicus) that were naïve to social defeat, females had higher levels of Dnmt1 expression in punch samples of the central amygdala (CeA) than males...
April 12, 2017: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/28404993/impacts-of-bisphenol-a-and-ethinyl-estradiol-on-male-and-female-cd-1-mouse-spleen
#13
Robin B Gear, Scott M Belcher
The endocrine disruptor bisphenol A (BPA) and the pharmaceutical 17α-ethinyl estradiol (EE) are synthetic chemicals with estrogen-like activities. Despite ubiquitous human exposure to BPA, and the wide-spread clinical use of EE as oral contraceptive adjuvant, the impact of these estrogenic endocrine disrupting chemicals (EDCs) on the immune system is unclear. Here we report results of in vivo dose response studies that analyzed the histology and microstructural changes in the spleen of adult male and female CD-1 mice exposed to 4 to 40,000 μg/kg/day BPA or 0...
April 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28403740/bisphenol-a-induces-oxidative-stress-in-bone-marrow-cells-lymphocytes-and-reproductive-organs-of-holtzman-rats
#14
Dinesh Tiwari, Geeta Vanage
Bisphenol A (BPA) is an estrogenic chemical used in the production of polycarbonate plastics and epoxy resins. Our earlier studies have demonstrated that BPA is a potent reproductive and genotoxic agent and affects the normal physiological functions. The objective of this study was to evaluate whether exposure to BPA induces oxidative stress. The male Holtzman rats were orally gavaged with BPA (0.01 mg and 5.0 mg/kg/bw) over the period of 6 days. Animals were euthanized by cervical dislocation at the end of the treatments; bone marrow cells and blood lymphocytes were aspirated; testis and epididymis were collected, immediately frozen in liquid nitrogen, and stored at -80°C...
March 2017: International Journal of Toxicology
https://www.readbyqxmd.com/read/28402180/analytical-determination-of-bisphenol-a-bpa-and-bisphenol-analogues-in-paper-products-by-gc-ms-ms
#15
A Jurek, E Leitner
Bisphenol A (BPA; 4-[2-(4-Hydroxyphenyl)propan-2-yl]phenol), a suspected endocrine disruptor with a weak estrogenic activity is used in a variety of consumer products, including food contact materials made of paper and cardboard products. Due to restrictions for the use of BPA because of its potential health risks, BPA is gradually being replaced by other bisphenols, as no limitations exist for these substances. The present study presents a method for the simultaneous analysis of bisphenol A (BPA), bisphenol AF (BPAF), bisphenol B (BPB), bisphenol E (BPE), bisphenol F (BPF) and bisphenol S (BPS) in paper and board products, using gas chromatography-tandem mass spectrometry (GC-MS/MS)...
April 12, 2017: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/28400829/a-case-control-study-of-bisphenol-a-and-endometrioma-among-subgroup-of-iranian-women
#16
Batool Hossein Rashidi, Massoud Amanlou, Tahere Behrouzi Lak, Mahya Ghazizadeh, Bita Eslami
BACKGROUND: Endometriosis is a multifactorial hormonally related complex disease with unknown etiology. Epidemiologic data were suggested the possible effects of endocrine disrupting chemicals such as bisphenol A (BPA) on endometriosis. BPA is similar to endogenous estrogen and has the ability to interact with estrogen receptors and stimulate estrogen production. Our aim was to evaluate the relationship between urinary BPA concentrations in women with endometrioma. MATERIALS AND METHODS: This case-control study consisted of fifty women who have been referred to gynecology and infertility center with endometrioma and were candidates for operative laparoscopy and ovarian cystectomy as cases...
2017: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/28398246/direct-electrochemical-detection-of-bisphenol-a-using-a-highly-conductive-graphite-nanoparticle-film-electrode
#17
Xinwei Dong, Xiaoli Qi, Na Liu, Yuesuo Yang, Yunxian Piao
We developed an accurate and sensitive sensor for electrochemical detection of bisphenol A (BPA) with a high-conductivity graphite nanoparticle (GN) film electrode. The GNs consisted of several stacked graphene sheets and showed a homogenous spherical shape, high conductivity, large surface area and good adsorption properties to BPA. The constructed GN film electrode exhibited improved amperometric current responses such as decreased impedance and lowered BPA oxidation potential compared with those of a pristine electrode, and also possessed a large surface area to allow fast electron transfer and BPA accumulation...
April 11, 2017: Sensors
https://www.readbyqxmd.com/read/28395354/urinary-bisphenol-a-bpa-concentrations-among-workers-in-industries-that-manufacture-and-use-bpa-in-the-usa
#18
Cynthia J Hines, Matthew V Jackson, James A Deddens, John C Clark, Xiaoyun Ye, Annette L Christianson, Juliana W Meadows, Antonia M Calafat
Background: Bisphenol A (BPA) toxicity and exposure risk to humans has been the subject of considerable scientific debate; however, published occupational exposure data for BPA are limited. Methods: In 2013-2014, 77 workers at six US companies making BPA, BPA-based resins, or BPA-filled wax provided seven urine samples over two consecutive work days (151 worker-days, 525 samples). Participant information included industry, job, tasks, personal protective equipment used, hygiene behaviors, and canned food/beverage consumption...
March 1, 2017: Annals of Work Exposures and Health
https://www.readbyqxmd.com/read/28395312/assessment-of-occupational-exposure-to-bisphenol-a-in-five-different-production-companies-in-finland
#19
Milla Heinälä, Katriina Ylinen, Tapani Tuomi, Tiina Santonen, Simo P Porras
The aim of the study was to assess occupational exposure to bisphenol A in Finland. Five companies took part in the research project: two paint factories (liquid and powder paints), a composite product factory, a thermal paper factory, and a tractor factory. Exposure was assessed by measuring total bisphenol A excretion (free and conjugated) from urine samples, and its concentrations in the air. The results revealed the specific work tasks in two of five companies in which significant occupational exposure to bisphenol A may occur...
January 1, 2017: Annals of Work Exposures and Health
https://www.readbyqxmd.com/read/28394738/kinetic-and-isotherm-studies-of-bisphenol-a-adsorption-onto-orange-albedo-citrus-sinensis-sorption-mechanisms-based-on-the-main-albedo-components-vitamin-c-flavones-glycosides-and-carotenoids
#20
Theophile Kamgaing, Giscard Doungmo, Francis Merlin Melataguia Tchieno, Jimmy Julio Gouoko Kouonang, Ketcha Joseph Mbadcam
Orange albedo and its adsorption capacity towards bisphenol A (BPA) were studied. Adsorption experiments were conducted in batch mode at 25-55°C. Scanning electron microscopy (SEM), Energy dispersive X-ray spectroscopy (EDX), X-ray diffraction (XRD), Brunauer-Emmett-Teller (BET) and Fourier transform infrared (FTIR) spectroscopy were used to characterise the biosorbent. The effects of various parameters including adsorption time, equilibrium pH, adsorbent dosage and initial adsorbate concentration were investigated...
April 10, 2017: Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering
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