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https://www.readbyqxmd.com/read/28088650/assessing-the-identity-and-expression-level-of-the-cytochrome-p450-20a1-cyp20a1-gene-in-the-bpa-bde-47-and-waf-exposed-copepods-tigriopus-japonicus-and-paracyclopina-nana
#1
Jeonghoon Han, Duck-Hyun Kim, Jung Soo Seo, Il-Chan Kim, David R Nelson, Jayesh Puthumana, Jae-Seong Lee
CYP20A1 is a member of the cytochrome P450 (CYP) superfamily, identified as an orphan P450 without any assigned biological function; hence, its continued status as an "orphan" gene. In order to address this shortcoming in our understanding of this superfamily, we sought to characterize the CYP20A1 gene in the copepods Tigriopus japonicus (Tj-CYP20A1) and Paracyclopina nana (Pn-CYP20A1) at their mRNA transcriptional level. We assessed the response of this gene's expression in various developmental stages and in response to treatment with bisphenol A (BPA), 2, 2', 4, 4'-tetrabromodiphenyl ether (BDE-47), and water accommodated fractions (WAFs) of crude oil...
January 11, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/28087314/a-protective-role-of-cumulus-cells-after-short-term-exposure-of-rat-cumulus-cell-oocyte-complexes-to-lifestyle-or-environmental-contaminants
#2
Kelly A Campen, Kenneth P McNatty, Janet L Pitman
Ovarian follicular fluid provides a potential reservoir for exogenous compounds that may adversely affect oocyte quality. This study examined the effects of common lifestyle and environmental contaminants, namely bisphenol-A (BPA), caffeine, 3,4-methylenedioxymethamphetamine (MDMA), nicotine and Δ(9)-tetrahydrocannabinol on gap junction genes (Gja1, Gja4) and proteins (GJA1), glucose metabolism genes (Gfpt1, Pfkp) and oocyte growth factor genes (Bmp15, Gdf9), as well as gap junction transfer rate, in rat cumulus-oocyte complexes (COCs)...
January 10, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28080214/-1-h-nmr-based-metabolomic-studies-of-bisphenol-a-in-zebrafish-danio-rerio
#3
Changshin Yoon, Dahye Yoon, Junghee Cho, Siwon Kim, Heonho Lee, Hyeonsoo Choi, Suhkmann Kim
Proton nuclear magnetic resonance ((1)H-NMR) spectroscopy was used to study the response of zebrafish (Danio rerio) to increasing concentrations of bisphenol A (4,4'-(propane-2,2-diyl)diphenol, BPA). Orthogonal partial least squares discriminant analysis (OPLS-DA) was applied to detect aberrant metabolomic profiles after 72 h of BPA exposure at all levels tested (0.01, 0.1, and 1.0 mg/L). The OPLS-DA score plots showed that BPA exposure caused significant alterations in the metabolome. The metabolomic changes in response to BPA exposure generally exhibited nonlinear patterns, with the exception of reduced levels of several metabolites, including glutamine, inosine, lactate, and succinate...
January 12, 2017: Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes
https://www.readbyqxmd.com/read/28078498/perinatal-exposure-to-bisphenol-a-or-diethylstilbestrol-increases-the-susceptibility-to-develop-mammary-gland-lesions-after-estrogen-replacement-therapy-in-middle-aged-rats
#4
Ayelen L Gomez, Melisa B Delconte, Gabriela A Altamirano, Lucia Vigezzi, Veronica L Bosquiazzo, Luís F Barbisan, Jorge G Ramos, Enrique H Luque, Mónica Muñoz-de-Toro, Laura Kass
The development of the mammary gland is a hormone-regulated event. Several factors can dysregulate its growth and make the gland more susceptible to cellular transformation. Among these factors, perinatal exposure to xenoestrogens and hormone replacement therapy has been associated with increased risk of developing breast cancer. Here, we assessed the effects induced by estrogen replacement therapy (ERT) in ovariectomized (OVX) middle-aged rats and whether perinatal exposure to diethylstilbestrol (DES) or bisphenol A (BPA) modified these effects in the mammary gland...
January 11, 2017: Hormones & Cancer
https://www.readbyqxmd.com/read/28078411/in-vitro-and-in-silico-assessment-of-the-structure-dependent-binding-of-bisphenol-analogues-to-glucocorticoid-receptor
#5
Jie Zhang, Tiehua Zhang, Tianzhu Guan, Hansong Yu, Tiezhu Li
Widespread use of bisphenol A (BPA) and other bisphenol analogues has attracted increasing attention for their potential adverse effects. As environmental endocrine-disrupting compounds (EDCs), bisphenols (BPs) may activate a variety of nuclear receptors, including glucocorticoid receptor (GR). In this work, the binding of 11 BPs to GR was investigated by fluorescence polarization (FP) assay in combination with molecular dynamics simulations. The human glucocorticoid receptor was prepared as a soluble recombinant protein...
January 11, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28067316/long-term-exposure-to-a-safe-dose-of-bisphenol-a-reduced-protein-acetylation-in-adult-rat-testes
#6
Zhuo Chen, Xuezhi Zuo, Dongliang He, Shibin Ding, Fangyi Xu, Huiqin Yang, Xin Jin, Ying Fan, Li Ying, Chong Tian, Chenjiang Ying
Bisphenol A (BPA), a typical environmental endocrine-disrupting chemical, induces epigenetic inheritance. Whether histone acetylation plays a role in these effects of BPA is largely unknown. Here, we investigated histone acetylation in male rats after long-term exposure to a 'safe' dose of BPA. Twenty adult male rats received either BPA (50 μg/kg·bw/day) or a vehicle diet for 35 weeks. Decreased protein lysine-acetylation levels at approximately ~17 kDa and ~25 kDa, as well as decreased histone acetylation of H3K9, H3K27 and H4K12, were detected by Western blot analysis of testes from the treated rats compared with controls...
January 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28064073/exploring-the-effect-of-bisphenol-s-on-sludge-hydrolysis-and-mechanism-of-the-interaction-between-bisphenol-s-and-%C3%AE-amylase-through-spectrophotometric-methods
#7
Hang Yang, Guangying Hou, Li Zhang, Lei Ju, Chunguang Liu
Sewage sludge, as a very significant sources of BPS (up to 523mg/kg dw) introduction into the environment, must be handled properly. Therefore, it is important to access BPS removal and its effect on sludge treatment with the biological treatment. However, it is unclear for its effect on the hydrolysis of sludge. In this research, impact of BPS on sludge hydrolysis by α-Amylase is studied from the respect of component of soluble organic matter in sludge using three-dimensional fluorescence spectra. Enzyme activity assay suggests that sludge hydrolysis is inhibited due to the denaturation of α-Amylase with BPS exposure...
December 22, 2016: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28063316/salivary-bisphenol-a-levels-and-their-association-with-composite-resin-restoration
#8
Jung-Ha Lee, Seung-Kyoo Yi, Se-Yeon Kim, Ji-Soo Kim, Sung-Ae Son, Seung-Hwa Jeong, Jin-Bom Kim
Composite resin has been increasingly used in an effort to remove minimal amount of tooth structure and are used for restoring not just carious cavities but also cervical abrasion. To synthesize composite resin, bisphenol A (BPA) is used. The aim of the study was to measure the changes in salivary BPA level related with composite resin restoration. ELISA was used to examine the BPA levels in the saliva collected from 30 volunteers whose teeth were filled with composite resin. Salivary samples were collected immediately before filling and 5 min and 7 d after filling...
December 27, 2016: Chemosphere
https://www.readbyqxmd.com/read/28057006/bisphenol-a-promotes-cholesterol-absorption-in-caco-2-cells-by-up-regulation-of-npc1l1-expression
#9
Dan Feng, Jun Zou, Shanshan Zhang, Xuechun Li, Peiyang Li, Minqi Lu
BACKGROUND: Bisphenol A (BPA), an commonly exposed environmental chemicals in humans, has been shown to have a hypercholesterolemic effect with molecular mechanism not clear. Since intestinal cholesterol absorption plays a major role in maintaining total body cholesterol homeostasis, the present study is to investigate whether BPA affects cholesterol absorption in the intestinal Caco-2 cells. METHODS: The Caco-2 cells were pretreated with BPA at different concentrations for 24 h and then incubated with radioactive micellar cholesterol for 2 h...
January 6, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28054450/simultaneous-analysis-of-bisphenol-a-based-compounds-and-other-monomers-leaching-from-resin-based-dental-materials-by-uhplc-ms-ms
#10
Eveline Putzeys, Stevan M Cokic, Hui Chong, Mario Smet, Jeroen Vanoirbeek, Lode Godderis, Bart Van Meerbeek, Kirsten L Van Landuyt, Radu Corneliu Duca
Resin-based dental materials have raised debates concerning their safety and biocompatibility, resulting in a growing necessity of profound knowledge on the quantity of released compounds into the oral cavity. In this context, the aim of this study was to develop a comprehensive and reliable procedure based on liquid chromatography with mass spectrometry for the simultaneous analysis of various leached compounds (including bisphenol A based compounds) in samples from in vitro experiments. Different experiments were performed to determine the optimal analytical parameters, comprising mass spectrometry parameters, chromatographic separation conditions and sample preparation...
January 5, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28051323/bisphenol-a-interferes-with-swine-vascular-endothelial-cell-functions
#11
Giuseppina Basini, Simona Bussolati, Stefano Grolli, Roberto Ramoni, Francesca Grasselli
Several studies have demonstrated that the endocrine disruptor bisphenol A (BPA) negatively affects animal and human health. An angiogenic process has been suggested among the events disrupted by this molecule, but the underlying mechanisms have not yet been clarified. The effect of BPA on angiogenesis was investigated by means of a bioassay previously validated in our laboratory. Using immortalized swine aortic endothelial cell line (AOC), the development of new blood vessels through a three-dimensional in vitro angiogenesis assay was evaluated...
October 20, 2016: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28050635/biotransformation-and-reduction-of-estrogenicity-of-bisphenol-a-by-the-biphenyl-degrading-cupriavidus-basilensis
#12
Marie-Katherin Zühlke, Rabea Schlüter, Annett Mikolasch, Daniela Zühlke, Martin Giersberg, Henning Schindler, Ann-Kristin Henning, Heidi Frenzel, Elke Hammer, Michael Lalk, Uwe T Bornscheuer, Katharina Riedel, Gotthard Kunze, Frieder Schauer
The biphenyl-degrading Gram-negative bacterium Cupriavidus basilensis (formerly Ralstonia sp.) SBUG 290 uses various aromatic compounds as carbon and energy sources and has a high capacity to transform bisphenol A (BPA), which is a hormonally active substance structurally related to biphenyl. Biphenyl-grown cells initially hydroxylated BPA and converted it to four additional products by using three different transformation pathways: (a) formation of multiple hydroxylated BPA, (b) ring fission, and (c) transamination followed by acetylation or dimerization...
January 3, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28049663/reproducibility-of-urinary-biomarkers-in-multiple-24-h-urine-samples
#13
Qi Sun, Kimberly A Bertrand, Adrian A Franke, Bernard Rosner, Gary C Curhan, Walter C Willett
BACKGROUND: Limited knowledge regarding the reproducibility of biomarkers in 24-h urine samples has hindered the collection and use of the samples in epidemiologic studies. OBJECTIVE: We aimed to evaluate the reproducibility of various markers in repeat 24-h urine samples. DESIGN: We calculated intraclass correlation coefficients (ICCs) of biomarkers measured in 24-h urine samples that were collected in 3168 participants in the NHS (Nurses' Health Study), NHSII (Nurses' Health Study II), and Health Professionals Follow-Up Study...
January 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28045228/syringaresinol-a-renewable-and-safer-alternative-to-bisphenol-a-for-epoxy-amine-resins
#14
Marine Janvier, Louis Hollande, Abdus Samad Jaufurally, Miguel Pernes, Raphaël Ménard, Marina Grimaldi, Johnny Beaugrand, Patirck Balaguer, Paul-Henri Ducrot, Florent Allais
A renewable bis-epoxy, SYR-EPO, has been prepared from syringaresinol, a naturally occurring bisphenol deriving from sinapic acid, using a chemo-enzymatic synthetic pathway. Estrogenic activity test revealed no endocrine disruption for syringaresinol. Its glycidylation afforded bis-epoxy SYR-EPO with excellent yield and purity. This biobased safer epoxy precursor was then cured with conventional and renewable diamines for the preparation of epoxy-amine resins. The resulting thermosets were thermally and mechanically characterized (TGA, DSC and DMA)...
January 3, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28042023/diverse-pathways-of-epithelial-mesenchymal-transition-related-with-cancer-progression-and-metastasis-and-potential-effects-of-endocrine-disrupting-chemicals-on-epithelial-mesenchymal-transition-process
#15
Hae-Miru Lee, Kyung-A Hwang, Kyung-Chul Choi
Endocrine disrupting chemicals (EDCs) are natural or synthetic compounds that interfere with normal functions of natural hormones in the body, leading to a disruption of the endocrine system. Specifically, EDCs have the potential to cause formation of several hormone-dependent cancers, including breast, ovarian, and prostate cancers. Epithelial mesenchymal transition (EMT) process by which epithelial cells lose their cell polarity and cell-cell adhesion and acquire mesenchymal phenotype is closely associated with malignant transformation and the initiation of cancer metastasis...
December 29, 2016: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28038877/emissions-of-organic-pollutants-from-traffic-and-roads-priority-pollutants-selection-and-substance-flow-analysis
#16
Anna Markiewicz, Karin Björklund, Eva Eriksson, Yuliya Kalmykova, Ann-Margret Strömvall, Anna Siopi
A large number of organic pollutants (OPs) emitted from vehicles and traffic-related activities exhibit environmental persistence and a tendency to bioaccumulate, and may have detrimental long-term effects on aquatic life. The aim of the study was to establish a list of significant sources of OPs occurring in road runoff, identify the OPs emitted from these sources, select a number of priority pollutants (PP), and estimate the quantity of PPs emitted in a road environment case study using substance flow analysis (SFA)...
December 27, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/28038396/nitrogen-doped-carbon-quantum-dots-ag3po4-complex-photocatalysts-with-enhanced-visible-light-driven-photocatalytic-activity-and-stability
#17
Quanyi Chen, Yunfang Wang, Yawen Wang, Xiaochao Zhang, Donghong Duan, Caimei Fan
Novel nitrogen-doped carbon quantum dots/Ag3PO4 (NCQDs/Ag3PO4) complex photocatalysts were synthesized by a facile precipitation method at room temperature. The physical and chemical properties of Ag3PO4 and NCQDs/Ag3PO4 photocatalysts were detected through X-ray powder diffraction, field emission scanning electron microscopy, UV-vis diffuse reflectance spectroscopy, X-ray photoelectron spectroscopy and electron spin resonance techniques. The as-prepared 3-NCQDs/Ag3PO4 composite exhibited much higher activity than the pure Ag3PO4 for eliminating methyl orange and bisphenol A solution under visible light (λ>420nm)...
December 19, 2016: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28036005/bisphenol-a-and-ovarian-reserve-among-infertile-women-with-polycystic-ovarian-syndrome
#18
Wei Zhou, Fang Fang, Wenting Zhu, Zi-Jiang Chen, Yanzhi Du, Jun Zhang
To better understand possible effects of bisphenol A (BPA) exposure on ovarian reserve in women with polycystic ovary syndrome (PCOS), we measured creatinine adjusted urinary BPA (BPA_Cre) concentrations and used regression models to evaluate the association between urinary BPA level and antral follicle count (AFC), antimullerian hormone (AMH), day-3 follicle stimulating hormone levels (FSH) and inhibin B (INHB) in 268 infertile women diagnosed with PCOS. BPA was detected in all women with a median concentration of 2...
December 27, 2016: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28030787/dna-demethylation-mediated-by-down-regulated-tets-in-the-testes-of%C3%A2-rare-minnow-gobiocypris-rarus-under-bisphenol-a-exposure
#19
Cong Yuan, Yingying Zhang, Yan Liu, Song Wang, Zaizhao Wang
Inevitable BPA exposure resulted in disturbance of DNA methylation status and our published study suspected that BPA has the potentiality to disturb DNA demethylation and GSH production in Gobiocypris rarus testes. To confirm this conjecture, several experiments were carried out in the present study. Adult male G. rarus was exposed to 1, 15 and 225 μg L(-1) (nominal concentration) BPA for two weeks. The levels of 5-methylcytosine (5mC), 5-hydroxymethylcytosine (5hmC), glutathione (GSH), and enzyme levels for DNA methylation and GSH synthesis in the testes were detected...
December 21, 2016: Chemosphere
https://www.readbyqxmd.com/read/28025458/adverse-effects-of-maternal-exposure-to-bisphenol-f-on-the-anxiety-and-depression-like-behavior-of-offspring
#20
Naoko Ohtani, Hidetomo Iwano, Koshi Suda, Erika Tsuji, Kentaro Tanemura, Hiroki Inoue, Hiroshi Yokota
Bisphenol A (BPA), a well-known endocrine disruptor, is metabolized and eliminated rapidly from the body in adult animals. However, many authors have reported that perinatal BPA exposure alters development of the brain, reproductive system and behavior in the next generation. Recently, BPA substitutes, especially bisphenol F (BPF), have been used because of concerns about the influence of BPA on children, although the actual effects on the next generation are unknown. In this study, we observed behavioral adverse effects of the offspring of mice exposed to BPA or BPF in fetal period...
December 25, 2016: Journal of Veterinary Medical Science
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