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https://www.readbyqxmd.com/read/28238872/endovascular-treatment-of-intracavernous-internal-carotid-aneurysm-secondary-to-pituitary-infection-a-case-report
#1
Ligen Shi, Mading Zhou, Shenbin Xu, Qun Wu, Wei Yan, Jianmin Zhang
Intracavernous internal carotid artery (ICICA) aneurysm secondary to pituitary infection is exceedingly rare. We report an unusual case of a 63-year-old man who presented with acute left blepharoptosis and imaging findings of a pituitary infection. Interestingly, sudden onset of right blepharoptosis occurred after anti-infective therapy for ten days. Digital subtraction angiography revealed a right ICICA aneurysm. After six months of follow-up visits, enlargement of the ICICA aneurysm was observed, and the endovascular technique of a low-profile visualized intraluminal support (LVIS) stent combined with five detachable coils was successfully performed to treat the ICICA aneurysm with preservation of the internal carotid artery...
February 23, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28237348/early-postpartum-administration-of-equine-chorionic-gonadotropin-to-dairy-cows-calved-during-the-hot-season-effects-on-fertility-after-first-artificial-insemination
#2
R Patron-Collantes, I Lopez-Helguera, J L Pesantez-Pacheco, F Sebastian, M Fernández, O Fargas, S Astiz
Heat stress reduces fertility of high-producing dairy cows, and early administration of equine chorionic gonadotropin (eCG) may improve it. Here, 401 heat-stressed, high-producing dairy cows on a single commercial farm were given eCG (500 UI, n = 214) or saline (n = 187) on days 11-17 after calving, and the effects on fertility after the first artificial insemination (AI) were assessed. On post-partum day 96.34 ± 9.88, all cows were inseminated after a "double short Cosynch" synchronization protocol...
April 1, 2017: Theriogenology
https://www.readbyqxmd.com/read/28235790/short-term-regular-aerobic-exercise-reduces-oxidative-stress-produced-by-acute-high-intraluminal-pressure-in-the-adipose-microvasculature
#3
Austin T Robinson, Ibra S Fancher, Varadarajan Sudhahar, Jing Tan Bian, Marc Cook, Abeer M Mahmoud, Mohamed Ali, Masuko Ushio-Fukai, Michael D Brown, Tohru Fukai, Shane A Phillips
: High blood pressure has been shown to elicit impaired dilation in the vasculature. The purpose of this investigation was to elucidate the mechanisms through which high pressure may elicit vascular dysfunction, and determine the mechanisms through which regular aerobic exercise protects arteries against high pressure. METHODS: Male C57Bl6 mice were subjected to two weeks of voluntary running (~ 6km/day) for comparison to sedentary controls. Hind limb adipose resistance arteries were dissected from mice for measurement of flow-induced dilation (FID; with or without high intraluminal pressure exposure); or protein expression of NADPH oxidase II (NOX II) and superoxide dismutase (SOD)...
February 24, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28235784/localization-of-the-gate-and-selectivity-filter-of-the-full-length-p2x7-receptor
#4
Anja Pippel, Michaela Stolz, Ronja Woltersdorf, Achim Kless, Günther Schmalzing, Fritz Markwardt
The P2X7 receptor (P2X7R) belongs to the P2X family of ATP-gated cation channels. P2X7Rs are expressed in epithelial cells, leukocytes, and microglia, and they play important roles in immunological and inflammatory processes. P2X7Rs are obligate homotrimers, with each subunit having two transmembrane helices, TM1 and TM2. Structural and functional data regarding the P2X2 and P2X4 receptors indicate that the central trihelical TM2 bundle forms the intrinsic transmembrane channel of P2X receptors. Here, we studied the accessibility of single cysteines substituted along the pre-TM2 and TM2 helix (residues 327-357) of the P2X7R using as readouts (i) the covalent maleimide fluorescence accessibility of the surface-bound P2X7R and (ii) covalent modulation of macroscopic and single-channel currents using extracellularly and intracellularly applied methanethiosulfonate (MTS) reagents...
February 24, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28235713/gastroesophageal-reflux-is-not-associated-with-short-term-variability-of-parasympathetic-activity-in-children
#5
Jan Krzysztof Nowak, Agata Łaźniak, Aleksandra Lisowska, Zdzisława Kycler, Waldemar Bobkowski, Jarosław Walkowiak
PURPOSE: A lower parasympathetic activity was described in patients with the gastroesophageal reflux disease. We aimed to determine whether gastroesophageal reflux (GER) episodes are associated with a short-term parasympathetic tone variability in children. METHODS: In order to address this question we performed simultaneous 24-h esophageal multichannel intraluminal impedance-pH and electrocardiographic monitoring in 16 children (age range 6-18 years), including 8 with asthma and 2 with gastroesophageal reflux disease...
February 21, 2017: Advances in Medical Sciences
https://www.readbyqxmd.com/read/28231003/utilization-of-gastrointestinal-simulator-gis-an-in-vivo-predictive-dissolution-methodology-coupled-with-computational-approach-to-forecast-oral-absorption-of-dipyridamole
#6
Kazuki Matsui, Yasuhiro Tsume, Susumu Takeuchi, Amanda Searls, Gordon L Amidon
Weakly basic drugs exhibit a pH-dependent dissolution profile in the gastrointestinal (GI) tract, making it difficult to predict their oral absorption profile. The aim of this study was to investigate the utility of the Gastrointestinal Simulator (GIS), a novel in vivo predictive dissolution (iPD) methodology, in predicting the in vivo behavior of the weakly basic drug, dipyridamole, when coupled with in silico analysis. The GIS is a multi-compartmental dissolution apparatus, which represents physiological gastric emptying in the fasted state...
February 23, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28224661/recurrent-obstructive-fibrinous-tracheal-pseudomembranes-in-a-young-english-bulldog
#7
E Robin, L V Guieu, K Le Boedec
Endotracheal intubation is a common procedure, rarely associated with life-threatening complications (e.g., tracheal rupture, necrosis, foreign body). A 1.5-year-old English Bulldog was presented for respiratory distress, with increased respiratory efforts and stridor, 2 days after endotracheal intubation. Cervical and thoracic radiographs disclosed a severe narrowing of the tracheal lumen associated with an intraluminal soft-tissue structure at the thoracic inlet. Tracheoscopy confirmed the presence of an obstructive fibrinous tracheal pseudomembrane (OFTP) creating a 1-way valve obstruction...
February 22, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28221670/endophlebectomy-of-the-common-femoral-vein-and-arteriovenous-fistula-creation-as-adjuncts-to-venous-stenting-for-post-thrombotic-syndrome
#8
M A F de Wolf, H Jalaie, J H H van Laanen, R L M Kurstjens, M J S Mensinck, M J de Geus, A Gombert, R de Graaf, C H A Wittens
BACKGROUND: Good results have been reported for angioplasty and stenting of post-thrombotic lesions of the iliac and proximal femoral veins. If lesions at the origin of the superficial femoral and profunda veins are stented, the intraluminal synechiae can be pushed against the orifices of inflow vessels, potentially decreasing stent inflow. Surgical disobliteration of the common femoral vein (endophlebectomy) has been suggested to mitigate this problem. Because of a temporary increase in thrombogenicity, this procedure may be accompanied by arteriovenous fistula creation...
February 21, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28220880/parenteral-administration-of-factor-xa-iia-inhibitors-limits-experimental-aortic-aneurysm-and-atherosclerosis
#9
Corey S Moran, Sai-Wang Seto, Smriti M Krishna, Surabhi Sharma, Roby J Jose, Erik Biros, Yutang Wang, Susan K Morton, Jonathan Golledge
Intraluminal thrombus is a consistent feature of human abdominal aortic aneurysm (AAA). Coagulation factor Xa (FXa) catalyses FII to thrombin (FIIa). We examined the effect of FXa/FIIa inhibition on experimental aortic aneurysm in apolipoprotein E-deficient (ApoE(-/-)) mice infused with angiotensin II (AngII). The concentration of FXa within the supra-renal aorta (SRA) correlated positively with SRA diameter. Parenteral administration of enoxaparin (FXa/IIa inhibitor) and fondaparinux (FXa inhibitor) over 14 days reduced to severity of aortic aneurysm and atherosclerosis in AngII-infused ApoE(-/-) mice...
February 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28216670/intraluminal-pressure-patterns-in-the-human-colon-assessed-by-high-resolution-manometry
#10
Ji-Hong Chen, Yuanjie Yu, Zixian Yang, Wen-Zhen Yu, Wu Lan Chen, Hui Yu, Marie Jeong-Min Kim, Min Huang, Shiyun Tan, Hesheng Luo, Jianfeng Chen, Jiande D Z Chen, Jan D Huizinga
Assessment of colonic motor dysfunction is rarely done because of inadequate methodology and lack of knowledge about normal motor patterns. Here we report on elucidation of intraluminal pressure patterns using High Resolution Colonic Manometry during a baseline period and in response to a meal, in 15 patients with constipation, chronically dependent on laxatives, 5 healthy volunteers and 9 patients with minor, transient, IBS-like symptoms but no sign of constipation. Simultaneous pressure waves (SPWs) were the most prominent propulsive motor pattern, associated with gas expulsion and anal sphincter relaxation, inferred to be associated with fast propagating contractions...
February 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28214966/anomalous-coronary-arteries-and-myocardial-bridges-risk-stratification-in-children-using-novel-cardiac-catheterization-techniques
#11
Hitesh Agrawal, Silvana Molossi, Mahboob Alam, S Kristen Sexson-Tejtel, Carlos M Mery, E Dean McKenzie, Charles D Fraser, Athar M Qureshi
The evaluation of the vast majority of children with anomalous aortic origin of a coronary artery (AAOCA) and/or myocardial bridges is performed with non-invasive testing. However, a subset of these patients may benefit from invasive testing for risk stratification. All patients included in the Coronary Anomalies Program (CAP) at Texas Children's Hospital who underwent cardiac catheterization were included. Techniques included selective coronary angiograms (SCA), intravascular ultrasound (IVUS), and fractional flow reserve (FFR) measurements with provocative testing using adenosine and/or dobutamine infusions...
February 18, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/28214352/gastro-oesophageal-reflux-in-patients-with-chronic-rhino-sinusitis-investigated-with-multichannel-impedance-ph-monitoring
#12
(no author information available yet)
INTRODUCTION: The pathophysiology of chronic rhinosinusitis (CRS) is unclear. It has been discussed for decades whether gastro-oesophageal reflux (GOR) may be a contributing factor for some patients. The aim of the present study was to evaluate the level of GOR in an unselected group of patients with CRS using multichannel impedance-pH monitoring. METHODS: Consecutive patients with CRS diagnosed using the EPOS2012 criteria, completed questionnaires on GOR symptoms and were offered 24-h multichannel intraluminal impedance (MII)-pH monitoring...
February 18, 2017: Rhinology
https://www.readbyqxmd.com/read/28213405/inhibition-of-the-mtor-pathway-in-abdominal-aortic-aneurysm-implication-of-smooth-muscle-cell-contractile-phenotype-inflammation-and-aneurysm-expansion
#13
Guangxin Li, Lingfeng Qin, Lei Wang, Xuan Li, Alexander W Caulk, Jian Zhang, Pei-Yu Chen, Shijie Xin
The development of effective pharmacological treatment of abdominal aortic aneurysm (AAA) potentially offers great benefit to patients with pre-aneurysmal aortic dilation by slowing the expansion of aneurysms and reducing the need for surgery. To date, therapeutic targets for slowing aortic dilation have had low efficacy. Thus, in this study, we aim to elucidate possible mechanisms driving aneurysm progression in order to identify potential targets for pharmacological intervention. We demonstrate that mTOR signaling is over activated in aortic smooth muscle cells (SMCs) which contributes to murine AAA...
February 17, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28213067/duodenal-gangliocytic-paraganglioma-successfully-treated-by-local-surgical-excision-a-case-report
#14
Dimetrios Papaconstantinou, Nikolaos Machairas, Vasileia Damaskou, Nikolaos Zavras, Christine Kontopoulou, Anastasios Machairas
INTRODUCTION: Duodenal gangliocytic paragangliomas are rare neoplasms often arising in proximity to the major duodenal papilla of Vater. These neoplasms are considered to have a benign behavior with lymph node metastases being a rare phenomenon and distant metastatic disease even more so. Resection of the tumor is the only definitive therapy. PRESENTATION OF CASE: A 67year old male presented to a referring hospital with symptoms of fatigue and malaise. Evaluation with CT imaging revealed a 3...
January 19, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28210834/conservative-treatment-in-uncomplicated-acute-appendicitis-reassessment-of-practice-safety
#15
Zvi Steiner, Genady Buklan, Rodica Stackievicz, Michael Gutermacher, Ita Litmanovitz, Guy Golani, Shmuel Arnon
: The success rate of conservative treatment for children with uncomplicated appendicitis was prospectively evaluated among 197 children. All who received intravenous antibiotics for 3-5 days, and if symptoms resolved, were discharged home on oral antibiotics for 5 days. Failure rate, symptoms, laboratory signs, and sonographic findings were evaluated for prognostic markers of treatment failure. Children were followed for 18 months. The success rate of conservative treatment was 87%, with shorter hospital stays compared to children who eventually needed surgery (72 [60-84] vs...
February 16, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28195732/in-vivo-predictive-dissolution-ipd-and-biopharmaceutical-modeling-and-simulation-future-use-of-modern-approaches-and-methodologies-in-a-regulatory-context
#16
H Lennernas, A Lindahl, A Van Peer, C Ollier, T Flanagan, R Lionberger, A Nordmark, S Yamashita, L Yu, G L Amidon, V Fischer, E Sjögren, P Zane, M McAllister, B Abrahamsson
The overall objective of OrBiTo, a project within Innovative Medicines Initiative (IMI), is to streamline and optimize the development of orally administered drug products through the creation and efficient application of biopharmaceutics tools. This toolkit will include both experimental and computational models developed on improved understanding of the highly dynamic gastrointestinal (GI) physiology relevant to the GI absorption of drug products in both fasted and fed states. A part of the annual OrBiTo-meeting in 2015 was dedicated to the presentation of the most recent progress in the development of the regulatory use of PBPK in silico modeling, in vivo predictive dissolution (IPD) tests and their application to biowaivers...
February 14, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28195642/functional-mucous-layer-and-healing-of-proximal-colonic-anastomoses-in-an-experimental-model
#17
J W A M Bosmans, A C H M Jongen, G M H Birchenough, E E L Nyström, M J J Gijbels, J P M Derikx, N D Bouvy, G C Hansson
BACKGROUND: Anastomotic leakage (AL) is the most dreaded complication after colorectal surgery, causing high morbidity and mortality. Mucus is a first line of defence against external factors in the gastrointestinal tract. In this study, the structural mucus protein Muc2 was depleted in genetically engineered mice and the effect on healing of colonic anastomoses studied in an experimental model. METHODS: Mice of different Muc2 genotypes were used in a proximal colonic AL model...
February 13, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28195136/relationships-between-motor-patterns-and-intraluminal-pressure-in-the-3-taeniated-proximal-colon-of-the-rabbit
#18
Xiaojing Quan, Zixian Yang, Mai Xue, Ji-Hong Chen, Jan D Huizinga
Manometry is used worldwide to assess motor function of the gastrointestinal tract, and the measured intraluminal pressure patterns are usually equated with contraction patterns. In the colon, simultaneous pressure increases throughout the entire colon are most often called simultaneous contractions, although this inference has never been verified. To evaluate the relationship between pressure and contraction in the colon we performed high-resolution manometry and measured diameter changes reflecting circular muscle contractions in the rabbit colon...
February 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28195071/spatial-differences-of-matrix-metalloproteinase-2-and-matrix-metalloproteinase-9-within-abdominal-aortic-aneurysm-wall-and-intraluminal-thrombus
#19
A Siennicka, M Zuchowski, M Kaczmarczyk, M Cnotliwy, J S Clark, M Jastrzebska
Formation of an abdominal aortic aneurysm is a complex process involving aortic wall degradation. The matrix metalloproteinases (MMPs) mainly involved in this process are MMP-2 and MMP-9. Most aneurysms contain an intraluminal thrombus. It is suggested that the thrombus' thickness correlates with the risk of aneurysm rupture and may be a new prognostic factor. The purpose of the present study was to investigate enzyme protein levels in thick (A1) and thin (B1) segments of the thrombus and aneurysm wall sections A (adjacent to A1) and B (adjacent to B1)...
December 2016: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/28190556/cotransplantation-of-neuroepithelial-stem-cells-with-interstitial-cells-of-cajal-improves-neuronal-differentiation-in-a-rat-aganglionic-model
#20
Lijuan Zhang, Bin Zhao, Wei Liu, Rui Ma, Rongde Wu, Yingmao Gao
BACKGROUND: Recent advances have raised the possibility of treating Hirschsprung's disease (HSCR) with transplanted neural stem cells. Although these cells have been shown to migrate and differentiate after transplantation, the restoration of intestinal motility by grafted cells is also mediated via the interstitial cells of Cajal (ICCs). We therefore aimed to evaluate the effect of cografting with ICC on neural stem cells after transplanted into aganglionic bowel. METHODS: Neuroepithelial stem cells (NESCs) and ICCs were isolated from neural tube of embryonic rat (embryonic day 11...
February 4, 2017: Journal of Pediatric Surgery
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