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https://www.readbyqxmd.com/read/28318647/prospective-evaluation-of-peripherally-inserted-central-catheter-complications-in-both-inpatient-and-outpatient-settings
#1
Christina Liscynesky, Jessica Johnston, Kelci E Haydocy, Kurt B Stevenson
We describe a prospective observational cohort (N = 187) to evaluate peripherally inserted central catheter line complications concurrently from the time of placement until removal. A significantly higher percentage of patients who experienced intraluminal thrombosis were receiving total parenteral nutrition (P ≤ .001) and had a dual lumen catheter (P = .01). Among patients with a confirmed or suspected infection, a significantly higher proportion received total parenteral nutrition (P = .01), had dual-lumen catheters (P = ...
March 16, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/28317452/recent-advances-in-diagnostic-testing-for-gastroesophageal-reflux-disease
#2
Rishi D Naik, Michael F Vaezi
Gastroesophageal reflux disease (GERD) has a large economic burden with important complications that include esophagitis, Barrett's esophagus, and adenocarcinoma. Despite endoscopy, validated patient questionnaires, and traditional ambulatory pH monitoring, the diagnosis of GERD continues to be challenging. Areas covered: This review will explore the difficulties in diagnosing GERD with a focus on new developments, ranging from basic fundamental changes (histology and immunohistochemistry) to direct patient care (narrow-band imaging, impedance, and response to anti-reflux surgery)...
March 20, 2017: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28317235/astrocyte-specific-insulin-like-growth-factor-1-gene-transfer-in-aging-female-rats-improves-stroke-outcomes
#3
Andre K Okoreeh, Shameena Bake, Farida Sohrabji
Middle aged female rats sustain larger stroke infarction and disability than younger female rats. This older group also shows age-related reduction of insulin like growth factor (IGF)-1 in serum and in astrocytes, a cell type necessary for poststroke recovery. To determine the impact of astrocytic IGF-1 for ischemic stroke, these studies tested the hypothesis that gene transfer of IGF-1 to astrocytes will improve stroke outcomes in middle aged female rats. Middle aged (10-12 month old), acyclic female rats were injected with recombinant adeno-associated virus serotype 5 (AAV5) packaged with the coding sequence of the human (h)IGF-1 gene downstream of an astrocyte-specific promoter glial fibrillary acidic protein (GFAP) (AAV5-GFP-hIGF-1) into the striatum and cortex...
March 20, 2017: Glia
https://www.readbyqxmd.com/read/28304189/physiological-remodeling-of-bifurcation-aneurysms-preclinical-results-of-the-eclips-device
#4
Thomas R Marotta, Howard A Riina, Ian McDougall, Donald R Ricci, Monika Killer-Oberpfalzer
OBJECTIVE Intracranial bifurcation aneurysms are complex lesions for which current therapy, including simple coiling, balloon- or stent-assisted coiling, coil retention, or intrasaccular devices, is inadequate. Thromboembolic complications due to a large burden of intraluminal metal, impedance of access to side branches, and a high recurrence rate, due largely to the unmitigated high-pressure flow into the aneurysm (water hammer effect), are among the limitations imposed by current therapy. The authors describe herein a novel device, eCLIPs, and its use in a preclinical laboratory study that suggests the device's design and functional features may overcome many of these limitations...
March 17, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28303274/design-of-a-wireless-medical-capsule-for-measuring-the-contact-pressure-between-a-capsule-and-the-small-intestine
#5
Pengbo Li, Craig Kreikemeier-Bower, Wanchuan Xie, Vishal Kothari, Benjamin S Terry
A wireless medical capsule for measuring the contact pressure between a mobile capsule and the small intestine lumen was developed. Two pressure sensors were used to measure and differentiate the contact pressure and the small intestine intraluminal pressure. After in vitro tests of the capsule, it was surgically placed and tested in the proximal small intestine of a pig model. The capsule successfully gathered and transmitted the pressure data to an ex vivo receiver. The measured pressure signals in the animal test were analyzed in the time and frequency domains and a mathematic model was presented to describe the different factors influencing the contact pressure...
March 17, 2017: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/28302649/endothelial-protective-monocyte-patrolling-in-large-arteries-intensified-by-western-diet-and-atherosclerosis
#6
Amado Quintar, Sara McArdle, Dennis Wolf, Alex Marki, Erik Ehinger, Melanie Vassallo, Jacqueline F Miller, Zbigniew Mikulski, Klaus Ley, Konrad Buscher
Rationale: Non-classical mouse monocyte (CX3CR1(high), Ly-6C(low)) patrolling along the vessels of the microcirculation is critical for endothelial homeostasis and inflammation. Due to technical challenges it is currently not established how patrolling occurs in large arteries. Objective: This study was undertaken to elucidate the molecular, migratory and functional phenotype of patrolling monocytes in the high shear and pulsatile environment of large arteries in healthy, hyperlipidemic and atherosclerotic conditions...
March 16, 2017: Circulation Research
https://www.readbyqxmd.com/read/28297055/any-use-for-alternative-lock-solutions-in-the-prevention-of-catheter-related-blood-stream-infections
#7
Laura Labriola, Jean-Michel Pochet
The prevention of catheter-related blood stream infections (CRBSI) in hemodialysis (HD) patients remains a challenge because of high morbidity and mortality associated to CRBSI. Alternative locking solutions (ALS) containing an antithrombotic substance with additional antimicrobial or antibiofilm properties (citrate, ethylenediaminetetraacetic acid [EDTA], 70% ethanol, thrombolytics) with or without the addition of molecules with specific antimicrobial activity (antibiotics, taurolidine, paraben-methylene-blue) has been proposed with the aim to prevent or eradicate intraluminal biofilm colonization and subsequent CRBSI...
March 6, 2017: Journal of Vascular Access
https://www.readbyqxmd.com/read/28292588/endoscopy-after-esophagectomy-safety-demonstrated-in-a-porcine-model
#8
Vignesh Raman, Karen L Moodie, Obinna O Ofoche, Larry R Kaiser, Cherie P Erkmen
BACKGROUND: Endoscopy is useful in assessing conduit ischemia and anastomotic leaks after esophagectomy but poses a theoretical threat of anastomotic disruption. We used a porcine model to evaluate the safety of endoscopy after esophagectomy. METHODS: We performed esophagectomies in 10 live pigs and performed endoscopy with progressive air insufflation and continuous intraluminal pressure monitoring. We stopped insufflation when the intraluminal pressure reached a plateau...
February 9, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28288888/a-novel-modification-of-the-murine-elastase-infusion-model-of-abdominal-aortic-aneurysm-formation
#9
Guohua Hu, Zhihui Dong, Weiguo Fu
OBJECT: To create a novel procedure that will decrease the mortality of experimental animals in the intra-arterial infusion of elastase abdominal aortic aneurysm model. METHODS: Novel models were created by means of direct puncture the infrarenal abdominal aortic aorta, intraluminal elastase in the 1cm segment of abdominal aorta. Femoral artery cannula approach and infusing with elastase was considered as the traditional group, and that infusing with saline solution as the control group...
March 10, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28288870/tia-model-is-attainable-in-wistar-rats-by-intraluminal-occlusion-of-the-mca-for-10-min-or-shorter
#10
A Durukan Tolvanen, E Tatlisumak, E Pedrono, U Abo-Ramadan, T Tatlisumak
Transient ischemic attack (TIA) has received only little attention in the experimental research field. Recently, we introduced a TIA model for mice, and here we set similar principles for simulating this human condition in Wistar rats. In the model: 1) transient nature of the event is ensured, and 2) 24 h after the event animals are free from any sensorimotor deficit and from any detectable lesion by magnetic resonance imaging (MRI). Animals experienced varying durations of ischemia (5, 10, 12.5, 15, 25, and-30 min, n=6-8 per group) by intraluminal middle cerebral artery occlusion (MCAO)...
March 10, 2017: Brain Research
https://www.readbyqxmd.com/read/28281235/the-use-of-unidirectional-knotless-barbed-suture-for-enterotomy-closure-in-roux-en-y-gastric-bypass-a-randomized-comparative-study
#11
Ben Gys, Tobie Gys, Thierry Lafullarde
PURPOSE: In this study, we assessed feasibility, safety, and time efficiency of laparoscopic running enterotomy closure for linear stapled Roux-en-Y Gastric Bypass (RYGB) using unidirectional barbed sutures (Stratafix™ 2/0- Ethicon). MATERIALS AND METHODS: Two hundred patients undergoing laparoscopic RYGB were prospectively randomized regarding running enterotomy closure of the linear stapled gastrojejunal (GJA) and jejunojejunal anastomosis (JJA). Two groups were created: V-group (Vicryl® 2/0-Ethicon) and S-group (Stratafix™ 2/0-Ethicon)...
March 9, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28280468/rok-and-arteriolar-myogenic-tone-generation-molecular-evidence-in-health-and-disease
#12
REVIEW
Ahmed F El-Yazbi, Khaled S Abd-Elrahman
The myogenic response is an inherent property of resistance arteries that warrants a relatively constant blood flow in response to changes in perfusion pressure and protect delicate organs from vascular insufficiencies and excessive blood flow. This fundamental phenomenon has been extensively studied aiming to elucidate the underlying mechanisms triggering smooth muscle contraction in response to intraluminal pressure elevation, particularly, Rho-associated kinase (ROK)-mediated Ca(2+)-independent mechanisms...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28280387/ulva-lactuca-polysaccharides-prevent-wistar-rat-breast-carcinogenesis-through-the-augmentation-of-apoptosis-enhancement-of-antioxidant-defense-system-and-suppression-of-inflammation
#13
Gamal-Eldein F Abd-Ellatef, Osama M Ahmed, Eman S Abdel-Reheim, Abdel-Hamid Z Abdel-Hamid
BACKGROUND: Recently, several research studies have been focused on the isolation and function of the polysaccharides derived from different algal species, which revealed multiple biological activities such as antioxidant and antitumor activities. This study assesses the possible breast cancer chemopreventive properties of common seaweeds, sea lettuce, Ulva lactuca (ulvan) polysaccharides using in vitro bioassays on human breast cancer cell line (MCF-7) and an in vivo animal model of breast carcinogenesis...
2017: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/28273742/n-butyl-2-cyanoacrylate-nbca-embolus-in-the-graft-portal-vein-after-portosystemic-collateral-embolization-in-liver-transplantation-recipient-what-is-the-clinical-significance
#14
Hye Young Jang, Kyoung Won Kim, Jae Hyun Kwon, Heon-Ju Kwon, Bohyun Kim, Nieun Seo, Jeongjin Lee, Gi-Won Song, Sung-Gyu Lee
Background An N-butyl-2 cyanoacrylate (NBCA) embolus in the graft portal vein was frequently observed after an intraoperative embolization of portosystemic collaterals performed to prevent portal steal in liver transplant (LT) recipients. The radiological and clinical features of NBCA emboli have not yet been described. Purpose To describe radiological and clinical features of NBCA embolus in graft portal vein after portosystemic collateral embolization in LT recipients. Material and Methods A total of 165 consecutive LT recipients who had undergone intraoperative NBCA embolization of varix were found in single institution's computerized databases of a clinical cohort of LT...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/28272672/primary-clear-cell-renal-cell-carcinoma-with-marked-intraluminal-mucin-secretion
#15
Oğuzhan Okcu, Kemal Behzatoğlu, Yasemin Çakir, Esra Paşaoğlu, Uğur Yücetaş
Clear cell renal cell carcinoma with mucin secretion is an unexpected situation. Primary renal adenocarcinoma and various metastatic carcinomas should be considered in the differential diagnosis. Prognostic significance is not yet fully known due to the limited number of reported cases, and these lesions have been grouped under unclassified renal cell carcinoma. In our study, clear cell renal cell carcinoma with significant luminal mucin secretion is discussed with its histological, histochemical and immunohistochemical features...
February 4, 2017: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/28268057/renal-sympathetic-denervation-system-via-intraluminal-ultrasonic-ablation-therapeutic-intravascular-ultrasound-design-and-preclinical-evaluation
#16
Gil Chernin, Iris Szwarcfiter, Yvonne Bausback, Michael Jonas
PURPOSE: To assess the safety and performance of a nonfocused and nonballooned ultrasonic (US) catheter-based renal sympathetic denervation (RDN) system in normotensive swine. MATERIALS AND METHODS: RDN with the therapeutic intravascular US catheter was evaluated in 3 experiments: (i) therapeutic intravascular US RDN vs a control group of untreated animals with follow-up of 30, 45, and 90 days (n = 6; n = 12 renal arteries for each group); (ii) therapeutic intravascular US RDN vs radiofrequency (RF) RDN in the contralateral artery in the same animal (n = 2; n = 4 renal arteries); and (iii) therapeutic intravascular US RDN in a recently stent-implanted renal artery (n = 2; n = 4 renal arteries)...
March 3, 2017: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/28267560/neurogenic-bladder-dysfunction-does-not-correlate-with-astrocyte-and-microglia-activation-produced-by-graded-force-in-a-contusion-induced-spinal-cord-injury
#17
Alvaro Munoz
Rodent models for the study of neurogenic bladder dysfunction after spinal cord injury (SCI) are difficult to standardize, particularly when evaluating the specific contribution of the SCI to end-organ function. The purpose of this study was to evaluate the degree of bladder dysfunction associated with a highly reproducible, contusion-induced SCI in female rats. An infinite horizon impactor was used to create a contusion SCI with a magnitude of either 100 or 150 kDyne at the T8/T9 thoracic region of female Sprague-Dawley rats...
March 3, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/28266291/intraluminal-postpancreatoduodenectomy-hemorrhage-last-5-years-experience
#18
Sebastian Vâlcea, Mircea Beuran, Mihaela Vartic
Background: One of the most significant complications following pancreaticoduodenectomy is represented by postoperative hemorrhage. AIM: This study undertook an analysis of the cases that presented intraluminal bleeding of mechanical gastrojejunal anastomosis following pancreatico duodenectomy (PD) in the last five years. Methods: From January 2012 until January 2017, 84 consecutive pancreaticoduodenectomies were performed and managed by the same surgical team. The preferred procedure of reconstruction was Whipple (76 patients)...
January 2017: Chirurgia
https://www.readbyqxmd.com/read/28264510/peripheral-and-cerebral-resistance-arteries-in-the-spontaneously-hypertensive-heart-failure-rat-effects-of-stilbenoid-polyphenols
#19
Danielle I Lee, Crystal Acosta, Christopher M Anderson, Hope D Anderson
Hypertension is associated with aberrant structure and mechanical properties of resistance arteries. We determined the effects of resveratrol, a non-flavonoid polyphenol found in foods such as red grapes, and structurally-similar analogues (pterostilbene and gnetol) on systolic blood pressure (SBP) and resistance arteries from the spontaneously hypertensive heart failure (SHHF) rat. SBP was elevated in 17-week-old SHHF vs. Sprague-Dawley rats (normotensive control; 194 ± 3 vs. 142 ± 6 mmHg, p < 0.01) and was unaffected by resveratrol, pterostilbene, or gnetol (2...
February 28, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28262538/bladder-perforation-after-augmentation-cystoplasty-determining-the-best-management-option
#20
Ted Lee, David J Kozminski, David A Bloom, Julian Wan, John M Park
INTRODUCTION: Delayed bladder perforation is a well-described complication after augmentation cystoplasty. Although the frequency, risk factors, and diagnostic challenges are well documented, discussions regarding management strategies are sparse. OBJECTIVE: We evaluated our experience of managing augmented bladder perforation to interrogate the hypothesis that non-operative management can be used effectively. STUDY DESIGN: We retrospectively evaluated the management of 10 patients with augmented bladder perforations over a 16-year period (Jan 2000-Jan 2016)...
February 10, 2017: Journal of Pediatric Urology
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