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Brain tumors AND complications

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https://www.readbyqxmd.com/read/29774873/-application-of-intraoperative-mri-combined-with-neuronavigation-in-microsurgical-resection-for-insular-glioma
#1
Quanwei Zhou, Li Xia, Kejun He, Sheng Yan, Xiaoping Xu, Xixi Li, Zhengsong Huang, Nu Zhang
To evaluate the value of intraoperative magnetic resonance imaging (iMRI) combined with neuronavigation for the resection of insular gliomas.
 Methods: From August 2014 to October 2017 in the First Hospital Affiliated to Sun Yat-sen University, clinical data of 41 patients with insular glioma, who underwent the surgery assisted with 3.0T iMRI and neuronavigation, were analyzed retrospectively, and the resection extent, complications and prognosis were evaluated.
 Results: Subtotal tumor resection was achieved in 21 patients and partial resection was done in 20 after iMRI scanning...
April 28, 2018: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/29772363/a-comprehensive-study-of-symptomatic-late-radiation-induced-complications-after-radiosurgery-for-brain-arteriovenous-malformation-incidence-risk-factors-and-clinical-outcomes
#2
Hirotaka Hasegawa, Shunya Hanakita, Masahiro Shin, Takehiro Sugiyama, Mariko Kawashima, Wataru Takahashi, Masaaki Shojima, Osamu Ishikawa, Hirofumi Nakatomi, Nobuhito Saito
OBJECT: Stereotactic radiosurgery (SRS) is widely used to treat brain arteriovenous malformation (AVM); however, detailed information on late radiation-induced complications (LRICs) is scarce. The goal of the present study was to characterize the incidence, risk factors, and clinical outcomes of LRICs based on our long-term follow-up data. METHODS: The outcomes of consecutive patients who underwent SRS for AVMs at our institution in 1990-2010 were analyzed. Cyst formation/encapsulated hematoma (CF/EH) and radiation-induced tumor (RIT) were defined as LRICs...
May 14, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29764031/-dynamic-retraction-microneurosurgery-for-the-treatment-of-medial-tentorial-meningiomas
#3
W Du, D Zhong, D Lü, J Li, H Y Huang, J Yang, Y T Wu, H J Xia, W Y Tang, X C Sun
Objective: To investigate the effectiveness and clinical significance of dynamic retraction microneurosurgery for the treatment of medial tentorial meningiomas. Methods: From January 2011 to December 2016, a cohort of 28 patients with medial tentorial meningiomas were treated by microneurosurgery at the First Affiliated Hospital of Chongqing Medical University. Patients who treated intraoperatively with dynamic retraction surgery from January 2014 to December 2016 were assigned into dynamic retraction group, and those with fixed retractors intraoperatively from January 2011 to December 2013 were assigned into retractor group...
May 8, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29755904/radiation-induced-cavernous-malformation-as-a-late-sequelae-of-stereotactic-radiosurgery-for-epilepsy
#4
Ethan A Winkler, Caleb Rutledge, Mariann Ward, Tarik Tihan, Patricia K Sneed, Nicholas Barbaro, Paul Garcia, Michael McDermott, Edward F Chang
Stereotactic radiosurgery (SRS) is a promising treatment for medically intractable mesial temporal lobe epilepsy. SRS for epilepsy has had an acceptable safety profile with reports of radiation-induced vascular malformations confined to central nervous system pathologies with prominent angiogenesis - namely, primary brain tumors, metastases, and arteriovenous malformations. Theoretical risks for radiation-induced lesions following radiosurgery for epilepsy have yet to be established. Of 13 patients treated in a pilot trial for medial temporal lobe epilepsy, one developed multiple delayed radiation-induced cavernous malformations following radiosurgery...
March 11, 2018: Curēus
https://www.readbyqxmd.com/read/29753293/risk-assessment-of-in-hospital-mortality-of-patients-with-epilepsy-a-large-cohort-study
#5
Yang Si, Xiaoqiang Xiao, Shunju Xiang, Jing Liu, Qianning Mo, Hongbin Sun
PURPOSE: This study aimed to explore the mortality risks of hospitalized patients with epilepsy (PWE). METHODS: Our data source was extracted from discharge abstracts in a hospital medical database. Various clinical variables, including demographical characteristics, natural features of epilepsy, and comprehensive set of comorbidities, were screened to investigate the risk. Comorbidities were defined using a validated ICD-10-based classification. The distributions of comorbid conditions and demographics were presented...
May 9, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29742711/pituitary-apoplexy-following-lumbar-fusion-surgery-in-prone-position-a-case-report
#6
Chunghee Joo, Geol Ha, Yeon Jang
RATIONALE: Pituitary apoplexy (PA) is a syndrome caused by acute hemorrhage or infarction of the pituitary gland, generally within a pituitary adenoma. PA following spinal surgery is a very rare complication and may be difficult to diagnose. However, early diagnosis of PA is essential for the timely treatment of pan-hypopituitarism and prevention of severe neurologic complications. PATIENT CONCERNS: A 73-year-old man had a posterior lumbar fusion surgery over a period of 8 hours on prone position...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29742589/clinical-factors-associated-with-icu-specific-care-following-supratentoral-brain-tumor-resection-and-validation-of-a-risk-prediction-score
#7
Lynze R Franko, Todd Hollon, Joseph Linzey, Christopher Roark, Venkatakrishna Rajajee, Kyle Sheehan, Magnus Teig, Shawn Hervey-Jumper, Jason Heth, Daniel Orringer, Craig A Williamson
OBJECTIVES: The postoperative management of patients who undergo brain tumor resection frequently occurs in an ICU. However, the routine admission of all patients to an ICU following surgery is controversial. This study seeks to identify the frequency with which patients undergoing elective supratentorial tumor resection require care, aside from frequent neurologic checks, that is specific to an ICU and to determine the frequency of new complications during ICU admission. Additionally, clinical predictors of ICU-specific care are identified, and a scoring system to discriminate patients most likely to require ICU-specific treatment is validated...
May 7, 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/29730064/risk-of-radiation-vasculopathy-and-stroke-in-pediatric-patients-treated-with-proton-therapy-for-brain-and-skull-base-tumors
#8
Matthew D Hall, Julie A Bradley, Ronny L Rotondo, Ricardo Hanel, Chetan Shah, Christopher G Morris, Philipp R Aldana, Daniel J Indelicato
PURPOSE: To estimate the rate of and identify risk factors for vasculopathy after proton therapy in pediatric patients with central nervous system and skull base tumors. METHODS AND MATERIALS: Between 2006 and 2015, 644 pediatric patients with central nervous system and skull base tumors were treated with proton therapy at a single institution. The 3 most common histologies were craniopharyngioma (n = 135), ependymoma (n = 135), and low-grade glioma (n = 131)...
March 29, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29719137/real-time-imaging-of-brain-tumor-for-image-guided-surgery
#9
REVIEW
Shuang Hu, Homan Kang, Yoonji Baek, Georges El Fakhri, Anren Kuang, Hak Soo Choi
The completion of surgical resection is a key prognostic factor in brain tumor treatment. This requires surgeons to identify residual tumors in theater as well as to margin the proximity of the tumor to adjacent normal tissue. Subjective assessments, such as texture palpation or visual tissue differences, are commonly used by oncology surgeons during resection to differentiate cancer lesions from normal tissue, which can potentially result in either an incomplete tumor resection, or accidental removal of normal tissue...
May 2, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29710367/spontaneous-intraventricular-hemorrhage-caused-by-sphenoid-meningioma
#10
Cherkaoui Mandour, Jawad Laaguili, Miloudi Gazzaz, Brahim El Mostarchid
INTRODUCTION:  Benign sphenoid meningioma presenting with an acute intraventricular hemorrhage is extremely uncommon. CASE REPORT:  We report a case of a 61-year-old man who was admitted after sudden onset of a severe headache. Brain computed tomography revealed a sphenoid meningioma with acute intraventricular hemorrhage. DISCUSSION:  Intraventricular hemorrhage caused by Meningiomas is infrequent. Several hypotheses have been proposed to explain the cause of hemorrhage...
April 30, 2018: Journal of Neurological Surgery. Part A, Central European Neurosurgery
https://www.readbyqxmd.com/read/29709735/safeness-and-utility-of-concomitant-intraoperative-monitoring-with-intraoperative-magnetic-resonance-imaging-in-children-a-pilot-study
#11
Sandra Dias, Johannes Sarnthein, Elisabeth Jehli, Marian Christoph Neidert, Luca Regli, Oliver Bozinov
OBJECTIVE: High-field intraoperative MR (ioMRI) has become increasingly available in neurosurgery centers. There is little experience with the combination of ioMRI with intraoperative neurophysiological neuromonitoring (IONM). We provide a first series of pediatric patients undergoing brain tumor surgery with 3T ioMRI and IONM. METHODS: We conducted a pilot study were we included all consecutive children operated for brain tumors between October 2013 and April 2016 where concomitant ioMRI and somatosensory evoked potentials (SEP) and motor evoked potentials (MEP) were used...
April 27, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29705034/preclinical-mri-studies-of-the-irradiated-brain
#12
Joel R Garbow, Christina I Tsien, Scott C Beeman
Radiation therapy (RT) plays a central role in the treatment of primary brain tumors. However, despite recent advances in RT treatment, local recurrences following therapy remain common. Radiation necrosis (RN) is a severe, late complication of radiation therapy in the brain. RN is a serious clinical problem often associated with devastating neurologic complications. Therapeutic strategies, including neuroprotectants, have been described, but have not been widely translated in routine clinical use. We have developed a mouse model that recapitulates all of the major pathologic features of late-onset RN for the purposes of characterizing the basic pathogenesis of RN, identifying non-invasive (imaging) biomarkers of RN that might allow for the radiologic discernment of tumor and RN, systematic testing of tumor and RN therapeutics, and exploring the complex interplay between RN pathogenesis and tumor recurrence...
April 25, 2018: Journal of Magnetic Resonance
https://www.readbyqxmd.com/read/29703483/the-role-of-podoplanin-in-cancer-associated-thrombosis
#13
Pegah Mir Seyed Nazari, Julia Riedl, Ingrid Pabinger, Cihan Ay
Venous thromboembolism (VTE) is a frequent and life-threatening complication in patients with cancer. The underlying mechanisms of cancer-associated VTE are still not completely understood. However, emerging studies indicate that the mechanisms differ across tumor types. A recent study revealed that in patients with brain tumors, podoplanin overexpression is strongly correlated with intratumoral thrombotic vessels, hypercoagulability and increased VTE risk. In vitro experiments demonstrated that platelet aggregation induced by human glioblastoma cells was highly podoplanin-dependent...
April 2018: Thrombosis Research
https://www.readbyqxmd.com/read/29694662/technique-of-localizing-the-central-sulcus-under-awaking-anesthesia-for-treatmeat-of-gliomas-in-or-near-motor-areas
#14
Wan Yi, Shujun Xu, Xingang Li, Xiangyu Ma
AIM: This study aimed to study the protective effect of intraoperative awakening and central sulcus location on motor function for patients with gliomas located in motor areas. METHODS: A total of 68 patients with gliomas in motor areas were intubated with a laryngeal mask and rapidly underwent craniotomy without scalp clips and awakening, followed by localization of the central sulcus by somatosensory evoked potential. To protect brain function, we resected the greatest degree of tumor as possible and then finished the close-skull under an awakened state or general anesthesia...
April 6, 2018: Turkish Neurosurgery
https://www.readbyqxmd.com/read/29682018/modern-microsurgical-resection-of-olfactory-groove-meningiomas-by-classical-bicoronal-subfrontal-approach-without-orbital-osteotomies
#15
Ghulam Farooq, Lal Rehman, Irum Bokhari, Syed Raza Hussain Rizvi
Background: The olfactory groove meningioma has always been surgically challenging. The common microscopic surgical procedures exercised involve modification of pterional or sub-frontal approaches with or without orbital osteotomies. However, we believe that orbital osteotomies are not mandatory to achieve gross total resection. Hence, this study was performed to evaluate the surgical outcomes of olfactory groove meningioma with bicoronal sub frontal approach but without orbital osteotomies...
April 2018: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/29681812/a-58-year-old-woman-with-left-sided-weakness-and-a-history-of-a-pediatric-brain-tumor-a-case-report
#16
Shaakir Hasan, Michael J Gigliotti, Melvin Deutsch, Stacey L Reed, Rodney E Wegner
Background: An uncommon but well-established complication of cranial irradiation is secondary neoplasm. This case presentation documents a radiation-induced malignant glioma 55 years after being diagnosed with "cerebral sarcoma," now defined as atypical meningioma. This not only represents the longest reported latency period for a patient initially receiving over 30 Gy, but also provides a valuable historical perspective of neuro-oncology. Clinical Presentation: A 58-year-old female presenting with progressive left-sided upper and lower extremity weakness with a past medical history significant for "cerebral sarcoma" was diagnosed with glioblastoma multiforme...
January 2018: Case Reports in Oncology
https://www.readbyqxmd.com/read/29681425/epidemiology-and-national-trends-in-prevalence-and-surgical-management-of-metastatic-spinal-disease
#17
Samantha R Horn, Ekamjeet S Dhillon, Gregory W Poorman, Jared C Tishelman, Frank A Segreto, Cole A Bortz, John Y Moon, Omar Behery, Nicholas Shepard, Bassel G Diebo, Shaleen Vira, Peter G Passias
Surgical treatment for spinal metastasis has benefited from improvements in surgical techniques. However, the trends in treatment and outcomes for spinal metastasis surgery have not been well-established in a pediatric population. Patients <20 years old with metastatic spinal tumors undergoing spinal surgery were identified in the KID database. Trends for spinal metastases treatment and patient outcomes were analyzed using weight-adjusted ANOVAs. 333 patients were identified in the KID database. The top five primary diagnoses were metastatic brain/spinal cord tumor (19...
April 19, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29676036/combination-of-isocitrate-dehydrogenase-1-idh1-mutation-and-podoplanin-expression-in-brain-tumors-identifies-patients-at-high-or-low-risk-of-venous-thromboembolism
#18
Pegah Nazari Mir Seyed, Julia Riedl, Matthias Preusser, Florian Posch, Johannes Thaler, Christine Marosi, Peter Birner, Gerda Ricken, Johannes A Hainfellner, Ingrid Pabinger, Cihan Ay
BACKGROUND: Venous thromboembolism (VTE) is a frequent complication in primary brain tumor patients. Independent studies revealed that podoplanin expression in brain tumors is associated with increased VTE risk, while the isocitrate dehydrogenase 1 (IDH1) mutation is associated with very low VTE risk. OBJECTIVES: To investigate the interrelation between intratumoral podoplanin expression and IDH1 mutation, and their mutual impact on VTE development. PATIENTS/METHODS: In a prospective cohort study, intratumoral IDH1 R132H mutation and podoplanin were determined in brain tumor specimens (mainly glioma) by immunohistochemistry...
April 19, 2018: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/29669134/giant-olfactory-groove-meningioma-2-staged-approach-2-dimensional-operative-video
#19
Alexandre B Todeschini, Mostafa Shahein, Alaa S Montaser, Douglas Hardesty, Bradley A Otto, Ricardo L Carrau, Daniel M Prevedello
A 42-yr-old female presented with an olfactory groove meningioma causing progressive vision loss and anosmia. Given the size of the tumor, we opted for a 2-stage surgery: endoscopic endonasal approach (EEA) followed by a craniotomy. Stage I surgery was a transcribriform transplanum EEA using a binostril 4-hand/2 surgeons (ENT and neuro) technique, with the patient positioned supine with the head slightly turned to the right side and tilted to the left, fixed in a 3-pin head clamp, under imaging guidance, in which we drilled out all the affected skull base bone, devascularized and debulked the tumor...
April 16, 2018: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29651429/therapeutic-potential-of-thymoquinone-in-glioblastoma-treatment-targeting-major-gliomagenesis-signaling-pathways
#20
REVIEW
Fabliha Ahmed Chowdhury, Md Kamal Hossain, A G M Mostofa, Maruf Mohammad Akbor, Muhammad Shahdaat Bin Sayeed
Glioblastoma multiforme (GBM) is one of the most devastating brain tumors with median survival of one year and presents unique challenges to therapy because of its aggressive behavior. Current treatment strategy involves surgery, radiotherapy, immunotherapy, and adjuvant chemotherapy even though optimal management requires a multidisciplinary approach and knowledge of potential complications from both the disease and its treatment. Thymoquinone (TQ), the main bioactive component of Nigella sativa L., has exhibited anticancer effects in numerous preclinical studies...
2018: BioMed Research International
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