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Brain tumors AND complications

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https://www.readbyqxmd.com/read/29137271/environmental-conditions-differentially-affect-neurobehavioral-outcomes-in-a-mouse-model-of-sepsis-associated-encephalopathy
#1
Mu-Huo Ji, Hui Tang, Dan Luo, Li-Li Qiu, Min Jia, Hong-Mei Yuan, Shan-Wu Feng, Jian-Jun Yang
Brain dysfunction remains a common complication after sepsis development and is an independent risk factor for a poorer prognosis and an increased mortality. Here we tested the hypothesis that the behavioral outcomes after lipopolysaccharides (LPS) administration are exacerbated by an impoverished environment (IE) and alleviated by an enriched environment (EE), respectively. Mice were randomly allocated in a standard environment (SE), an EE, or an IE for 4 weeks after LPS or normal saline (NS) administration...
October 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29130233/-clinical-features-and-prognosis-analysis-of-21-gastric-cancer-patients-with-pathological-complete-response-after-neoadjuvant-chemotherapy
#2
Liangqun Peng, Wei Yang, Zhandong Zhang, Hongxing Liu, Yawei Hua
OBJECTIVE: To evaluate the clinical features and prognosis of gastric cancer patients with pathological complete response (pCR) after neoadjuvant chemotherapy (NAC). METHODS: Clinical data of 159 gastric cancer patients who received NAC followed by surgical resection between January 2012 and December 2014 at the Affiliated Tumor Hospital of Zhengzhou University were collected and clinical features of those with pCR were analyzed retrospectively. Kaplan-Meier method was used to estimate 3-year overall survival (OS) rate and recurrence-free survival (RFS) rate...
October 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29114280/comparison-of-stereotactic-and-ultrasound-guided-biopsy-of-solid-supratentorial-tumor-a-preliminary-report
#3
Guru Dutta Satyarthee, P Sarat Chandra, Bhawani S Sharma, V S Mehta
Introduction: The computed tomography (CT) guided stereotactic biopsy (STB) is considered as method of choice for biopsy of intracranial mass lesions. However, it's disadvantages are frame fixation, time requirement for transportation between CT scan suit to the operation theater with added much higher equipment cost in the relatively resource scarred developing country. Ultrasound-guided biopsy (USGB) is relatively simpler, economical, less time consuming, and real-time procedure. Clinical Materials and Methods: Thirty-seven consecutively admitted patients with supratentorial brain tumors, who underwent biopsy of the lesion using CT compatible stereotactic and ultrasound-guided (USGB) procedure formed cohort of the study...
October 2017: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/29107723/results-of-a-policy-of-fast-tapering-of-steroids-after-resection-surgery-in-glioblastoma
#4
Ricardo Díez Valle, Victoria Becerra Castro, Miguel Marigil Sánchez, Jaime Gállego Pérez de Larraya, Jorge M Núñez-Córdoba, Sonia Tejada Solis
BACKGROUND: Corticosteroids are routinely used to treat brain tumors. While steroids have an immediate clinical benefit, their use can lead to a number of relevant complications, and a negative association with overall survival (OS) has been shown in glioblastoma (GBM) patients. There is no evidence in the literature regarding the ideal dose. We assessed the use of steroids in patients with GBM after resection surgery. METHODS: This is a cohort study of 131 newly diagnosed GBM patients that underwent tumor resection surgery...
October 28, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29100012/targeting-glioma-stem-cell-derived-pericytes-disrupts-the-blood-tumor-barrier-and-improves-chemotherapeutic-efficacy
#5
Wenchao Zhou, Cong Chen, Yu Shi, Qiulian Wu, Ryan C Gimple, Xiaoguang Fang, Zhi Huang, Kui Zhai, Susan Q Ke, Yi-Fang Ping, Hua Feng, Jeremy N Rich, Jennifer S Yu, Shideng Bao, Xiu-Wu Bian
The blood-tumor barrier (BTB) is a major obstacle for drug delivery to malignant brain tumors such as glioblastoma (GBM). Disrupting the BTB is therefore highly desirable but complicated by the need to maintain the normal blood-brain barrier (BBB). Here we show that targeting glioma stem cell (GSC)-derived pericytes specifically disrupts the BTB and enhances drug effusion into brain tumors. We found that pericyte coverage of tumor vasculature is inversely correlated with GBM patient survival after chemotherapy...
November 2, 2017: Cell Stem Cell
https://www.readbyqxmd.com/read/29097333/torcular-meningioma-with-multi-venous-sinuses-invasion-compensatory-drainage-veins-and-surgical-strategy-case-report
#6
Alberto Debernardi, Luca Quilici, Alessandro Lacamera, Edoardo Boccardi, Marco Cenzato
BACKGROUND: Torcular meningiomas involving major dural venous sinuses are rare entities and a great challenge for neurosurgeons. The deep knowledge of the patency of occlusion of the sinuses, the extent of the occlusion and potentially new developing of extra and intracranial collateral venous drainage as compensatory venous channels, are at the base of a correct operative strategy. CASE DESCRIPTION: A 45-year-old woman presented with persistent headache. Magnetic resonance imaging scan of the brain and digital subtraction angiography demonstrated a huge torcular meningioma with complete multi-venous-sinuses occlusion and a wide venous network for brain and tumor drainage...
October 30, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29096138/failed-epilepsy-surgery-deserves-a-second-chance
#7
Chrystal M Reed, Sandra Dewar, Itzhak Fried, Jerome Engel, Dawn Eliashiv
OBJECTIVES: Resective epilepsy surgery has been shown to have up to 70-80% success rates in patients with intractable seizure disorder. Around 20-30% of patients with Engel Classification III and IV will require reevaluation for further surgery. Common reasons for first surgery failures include incomplete resection of seizure focus, incorrect identification of seizure focus and recurrence of tumor. PATIENT AND METHODS: Clinical chart review of seventeen patients from a single adult comprehensive epilepsy program who underwent reoperation from 2007 to 2014 was performed...
October 23, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29096136/restrictive-transfusion-threshold-is-safe-in-high-risk-patients-undergoing-brain-tumor-surgery
#8
Yasmine Alkhalid, Carlito Lagman, John P Sheppard, Thien Nguyen, Giyarpuram N Prashant, Alyssa F Ziman, Isaac Yang
OBJECTIVE: To assess the safety of a restrictive threshold for the transfusion of red blood cells (RBCs) compared to a liberal threshold in high-risk patients undergoing brain tumor surgery. PATIENTS AND METHODS: We reviewed patients who were 50 years of age or older with a preoperative American Society of Anesthesiologists physical status class II to V who underwent open craniotomy for tumor resection and were transfused packed RBCs during or after surgery. We retrospectively assigned patients to a restrictive-threshold (a pretransfusion hemoglobin level <8g/dL) or a liberal-threshold group (a pretransfusion hemoglobin level of 8-10/dL)...
October 23, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29095257/efficacy-and-safety-of-bevacizumab-treatment-for-refractory-brain-edema-case-report
#9
Xiangying Meng, Rugang Zhao, Ge Shen, Dapeng Dong, Lijuan Ding, Shikai Wu
OBJECTIVE: This retrospective study investigated the efficacy and safety of bevacizumab treatment for refractory brain edema. METHODS: Between March 2009 and December 2015, bevacizumab was used to treat 59 cases of brain metastatic patients with refractory brain edema. The median dose of bevacizumab was 4.68 mg/kg (range 2.8-6.52 mg/kg). The clinical-pathological data, the efficacy, and the side effects of bevacizumab were recorded. Magnetic resonance imaging (MRI) was performed before and after bevacizumab treatment...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29070999/treatment-of-leptomeningeal-metastases-in-a-patient-with-non-small-cell-lung-cancer-harboring-egfr-t790m-mutation
#10
Hardy Niu, Junle Zhou, Harvinder Maan, Maurie Markman, Jiaxin Niu
BACKGROUND: Leptomeningeal metastasis (LM) is an uncommon complication in patients with solid tumors, associated with poor survival. However, LM appears to be more frequent in lung cancer patients with EGFR mutations, posing a unique clinical challenge to treating physicians. CASE PRESENTATION: We report the case of a 68-year-old Asian man with metastatic lung adenocarcinoma harboring an EGFR L858R mutation, which was initially treated with gefitinib. He developed disease progression 1 year later...
September 2017: Case Reports in Oncology
https://www.readbyqxmd.com/read/29067465/molecular-mechanisms-and-potential-prognostic-effects-of-rest-and-rest4-in-glioma-review
#11
Cuilin Li, Zhifei Wang, Xinyue Tang, Liu Zeng, Xitang Fan, Zhi Li
Glioma refers to a tumor of the brain and central nervous system, which is characterized by high incidence, high mortality and high recurrence rate. Although the association between glioma and the repressor element silencing transcription factor (REST) has been reported by numerous studies, the complicated regulatory mechanisms underlying REST remain unknown. REST is a transcriptional repressor that undergoes alternative splicing to produce splicing variants when transcribed. Previous studies have demonstrated that alternative splicing may serve a role in the outcome of glioma...
October 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29067440/cd-plld-co-delivering-docetaxel-and-mmp-9-sirna-plasmid-for-nasopharyngeal-carcinoma-therapy-in%C3%A2-vivo
#12
Tao Liu, Xidong Wu, Yigang Wang, Xiongjun Hou, Gang Jiang, Ting Wu, Huifen Xie, Minqiang Xie
The co-delivery of a drug and a target gene has become a primary strategy in cancer therapy. Based on our previous study, a synthesized star‑shaped co‑polymer consisting of β‑cyclodextrin (CD) and a poly(L‑lysine) dendron (PLLD) was used to co-deliver docetaxel (DOC) and matrix metalloproteinase 9 (MMP‑9) small interfering RNA, via CD‑PLLD/DOC/MMP‑9 complexes, into mice implanted with HNE‑1 human nasopharyngeal carcinoma (NPC) tumor cells in vivo. Unlike the commonly used amphiphilic co‑polymer micelles, the obtained CD derivative may be used directly for a combined delivery of nucleic acid and hydrophobic DOC without a complicated micellization process...
August 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29062690/paroxysmal-dysphasia-in-a-68%C3%A2-year-old-man-enhancing-the-mri-spectrum
#13
Ugur Sener, William O Tatum, Alfredo Quinones-Hinojosa, Deependra Mahato, Anteneh M Feyissa
Brain tumor-related epilepsy is a common complication of primary and metastatic brain tumors with seizures often representing the first manifestation of the tumor. The size and location of the tumor can make detection of epileptiform discharges on scalp electroencephalogram and safe surgical resection challenging. We describe a case of a patient with glioblastoma multiforme presenting as dominant temporal lobe epilepsy. Seizures were manifest as episodes of speech arrest on a background of long-standing history of episodic speech difficulty and headache...
2017: Epilepsy & Behavior Case Reports
https://www.readbyqxmd.com/read/29060931/primary-cardiac-sarcoma-complicated-with-cerebral-infarction-and-brain-metastasis-a-case-report-and-literature-review
#14
Yun-Peng Sun, Xuan Wang, Yong-Sheng Gao, Song Zhao, Yang Bai
In large autopsy series, the estimated frequency of primary tumors of the heart ranges from 0.0017% to 0.33%. Approximately 25% of primary cardiac tumors are malignant, and nearly 20% of these are sarcomas. To date, a completely feasible surgical resection remains the major treatment measure of cardiac sarcoma, especially for recurrent focal cardiac sarcoma and the recurrence of a restrictive metastasis. Although characteristically medical treatments are recommended, there is no consistent opinion for adjuvant radiotherapy and chemotherapy following an operation...
October 9, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/29054465/combating-malignant-astrocytes-strategies-mitigating-tumor-invasion
#15
REVIEW
Robyn A Umans, Harald Sontheimer
Malignant gliomas are glial-derived, primary brain tumors that carry poor prognosis. Existing therapeutics are largely ineffective and dramatically affect quality of life. The standard of care details a taxing combination of surgical resection, radiation of the resection cavity, and temozolomide (TMZ) chemotherapy, with treatment extending life by only an average of months (Maher et al., 2001; Stupp et al., 2005). Despite scientific and technological advancement, surgery remains the most important treatment modality...
October 17, 2017: Neuroscience Research
https://www.readbyqxmd.com/read/29052807/current-trends-in-mouse-models-of-glioblastoma
#16
REVIEW
Masafumi Miyai, Hiroyuki Tomita, Akio Soeda, Hirohito Yano, Toru Iwama, Akira Hara
Glioblastoma is the most deadly brain tumor type and is characterized by a severe and high rate of angiogenesis, remaining an incurable disease in the majority of cases. Mechanistic understanding of glioblastoma initiation and progression is complicated by the complexity of genetic and/or environmental initiating events and lack of clarity regarding the cell or tissue of origin. To determine these mechanisms, mouse models that recapitulate the molecular and histological characteristics of glioblastoma are required...
October 20, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29052046/headache-and-pregnancy-a-systematic-review
#17
A Negro, Z Delaruelle, T A Ivanova, S Khan, R Ornello, B Raffaelli, A Terrin, U Reuter, D D Mitsikostas
This systematic review summarizes the existing data on headache and pregnancy with a scope on clinical headache phenotypes, treatment of headaches in pregnancy and effects of headache medications on the child during pregnancy and breastfeeding, headache related complications, and diagnostics of headache in pregnancy. Headache during pregnancy can be both primary and secondary, and in the last case can be a symptom of a life-threatening condition. The most common secondary headaches are stroke, cerebral venous thrombosis, subarachnoid hemorrhage, pituitary tumor, choriocarcinoma, eclampsia, preeclampsia, idiopathic intracranial hypertension, and reversible cerebral vasoconstriction syndrome...
October 19, 2017: Journal of Headache and Pain
https://www.readbyqxmd.com/read/29039075/venous-thromboembolism-and-intracranial-hemorrhage-after-craniotomy-for-primary-malignant-brain-tumors-a-national-surgical-quality-improvement-program-analysis
#18
Joeky T Senders, Nicole H Goldhaber, David J Cote, Ivo S Muskens, Hassan Y Dawood, Filip Y F L De Vos, William B Gormley, Timothy R Smith, Marike L D Broekman
Venous thromboembolism (VTE), including deep venous thrombosis (DVT) and pulmonary embolism (PE), frequently complicates the postoperative course of primary malignant brain tumor patients. Thromboprophylactic anticoagulation is commonly used to prevent VTE at the risk of intracranial hemorrhage (ICH). We extracted all patients who underwent craniotomy for a primary malignant brain tumor from the National Surgical Quality Improvement Program (NSQIP) registry (2005-2015) to perform a time-to-event analysis and identify relevant predictors of DVT, PE, and ICH within 30 days after surgery...
October 16, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29035741/association-between-psychological-distress-subjective-cognitive-complaints-and-objective-neuropsychological-functioning-in-brain-tumor-patients
#19
Aiste Pranckeviciene, Vytenis Pranas Deltuva, Arimantas Tamasauskas, Adomas Bunevicius
OBJECTIVES: Psychological distress and cognitive impairment are common complications in patients with brain tumors that are associated with poor quality of life and worse prognosis. This pilot study aimed to evaluate the associations between psychological distress, subjective cognitive complaints and baseline neuropsychological performance of brain tumor patients before neurosurgery. PATIENTS AND METHODS: Sixty-two patients with various brain tumors referred for routine neuropsychological assessment 2-3days before neurosurgery participated in the study...
October 10, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29018653/chiari-type-1-malformation-induced-intracranial-hypertension-with-diffuse-brain-edema-treated-with-foramen-magnum-decompression-a-case-report
#20
Toshiki Fukuoka, Yusuke Nishimura, Masahito Hara, Shoichi Haimoto, Kaoru Eguchi, Satoshi Yoshikawa, Toshihiko Wakabayashi, Howard J Ginsberg
Chiari type 1 malformation (CM1) rarely causes papilloedema, which is indicative of high intracranial pressure with or without ventricular dilatation. Furthermore, concomitant brain parenchymal abnormalities have not been reported to date. In this paper, the authors report on a young woman of CM1-induced intracranial hypertension (ICH) with diffuse brain edema with a focus on venous sinus assessment, and discuss the surgical strategy. A 24-year-old woman presented to Nagoya University Hospital complaining of 4-year history of severe occipital headache and blurry vision with slowly progressive worsening...
October 2017: NMC Case Rep J
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