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https://www.readbyqxmd.com/read/29679463/cdp-choline-protects-liver-from-ischemia-reperfusion-injury-preserving-mitochondrial-function-and-reducing-oxidative-stress
#1
Cecilia Zazueta, Mabel Buelna-Chontal, Arturo Macías-López, Nadia G Román-Anguiano, Héctor González-Pacheco, Natalia Pavón, Rashidi Springall, Alberto Aranda-Frausto, Rafael Bojalil, Alejandro Silva-Palacios, Rodrigo Velázquez-Espejel, Sonia Galvan Arzate, Francisco Correa
CDP-choline (citicoline) participates as intermediary in the synthesis of phosphatidylcholine, an essential component of cellular membranes. Citicoline treatment has shown beneficial effects in cerebral ischemia, but its potential to diminish reperfusion damage in liver has not been explored. In this work, we evaluated the hepatoprotective effect of citicoline and its possible association with inflammatory/oxidative stress and mitochondrial function, as they are main cellular features of reperfusion damage...
April 20, 2018: Liver Transplantation
https://www.readbyqxmd.com/read/29678911/food-spoilage-associated-leuconostoc-lactococcus-and-lactobacillus-species-display-different-survival-strategies-in-response-to-competition
#2
Margarita Andreevskaya, Elina Jääskeläinen, Per Johansson, Anne Ylinen, Lars Paulin, Johanna Björkroth, Petri Auvinen
Psychrotrophic lactic acid bacteria (LAB) are the prevailing spoilage organisms in packaged cold-stored meat products. Species composition and metabolic activities of such LAB spoilage communities are determined by the nature of meat product, storage condition and interspecies interactions. Our knowledge of systems-level responses of LAB during such interactions is very limited. To expand it, we studied interactions between three common psychrotrophic spoilage LAB ( Leuconostoc gelidum , Lactococcus piscium and Lactobacillus oligofermentans ) by comparing their time-course transcriptome profiles obtained during their growth in individual, pairwise and triple cultures...
April 20, 2018: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29678738/autochthonous-lactic-acid-bacteria-isolated-from-pig-faeces-in-thailand-show-probiotic-properties-and-antibacterial-activity-against-enteric-pathogenic-bacteria
#3
Wandee Sirichokchatchawan, Puwiya Pupa, Prasert Praechansri, Nutthee Am-In, Somboon Tanasupawat, Piengchan Sonthayanon, Nuvee Prapasarakul
Lactic acid bacteria (LAB) play an important role in pig health and performance that arises from their beneficial impacts on the balance of gastrointestinal microbes, ability to fight enteric pathogens, and capacity to support the immune system. The aim of this study was to evaluate the functional and safety aspects of five previously isolated autochthonous LAB strains, (Lactobacillus plantarum 22F, 25F and 31F, Pediococcus acidilactici 72N and Pediococcus pentosaceus 77F) from pig faeces as potential probiotics for a pig feed supplement...
April 17, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29678619/effect-of-goal-directed-fluid-therapy-on-early-cognitive-function-in-elderly-patients-with-spinal-stenosis
#4
Na Zhang, Min Liang, Dan-Dan Zhang, Yi-Rong Xiao, Yan-Zhen Li, You-Guang Gao, Hong-da Cai, Xian-Zhong Lin, Cai-Zhu Lin, Kai Zeng, Xiao-Dan Wu
PURPOSE: To explore effect of goal-directed fluid therapy (GDFT) on early cognitive function in elderly patients with spinal stenosis. METHODS: 83 elderly patients with spinal stenosis were randomly classified into two groups: control group (n = 40) and GDFT group (n = 43). The Montreal Cognitive Assessment (MoCA) score, IL-6 and S100β levels, hemodynamic parameters, cerebral oxygen saturation (rSO2 ), arterial lactic acid values, output of surgery, operation time and cases of hypotension, intraoperative complications within 7 days were recorded for all patients...
April 17, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29678198/metabolic-retroconversion-of-trimethylamine-n-oxide-and-the-gut-microbiota
#5
Lesley Hoyles, Maria L Jiménez-Pranteda, Julien Chilloux, Francois Brial, Antonis Myridakis, Thomas Aranias, Christophe Magnan, Glenn R Gibson, Jeremy D Sanderson, Jeremy K Nicholson, Dominique Gauguier, Anne L McCartney, Marc-Emmanuel Dumas
BACKGROUND: The dietary methylamines choline, carnitine, and phosphatidylcholine are used by the gut microbiota to produce a range of metabolites, including trimethylamine (TMA). However, little is known about the use of trimethylamine N-oxide (TMAO) by this consortium of microbes. RESULTS: A feeding study using deuterated TMAO in C57BL6/J mice demonstrated microbial conversion of TMAO to TMA, with uptake of TMA into the bloodstream and its conversion to TMAO. Microbial activity necessary to convert TMAO to TMA was suppressed in antibiotic-treated mice, with deuterated TMAO being taken up directly into the bloodstream...
April 20, 2018: Microbiome
https://www.readbyqxmd.com/read/29677662/exploring-the-potential-of-lactic-acid-production-from-lignocellulosic-hydrolysates-with-various-ratios-of-hexose-versus-pentose-by-bacillus-coagulans-ipe22
#6
Yujue Wang, Weifeng Cao, Jianquan Luo, Yinhua Wan
The aim of this study was to investigate the feasibility of utilizing different lignocellulosic hydrolysates with various hexose versus pentose (H:P) ratios to produce lactic acid (LA) from Bacillus coagulans IPE22 by fermentations with single and mixed sugar. In single sugar utilization, glucose tended to promote LA production, and xylose preferred to enhance cell growth. In mixed sugar utilization, glucose and pentose were consumed simultaneously when glucose concentration was lower than 20 g/L, and almost the same concentration of LA (50 g/L) was obtained regardless of the differences of H:P values...
April 5, 2018: Bioresource Technology
https://www.readbyqxmd.com/read/29677404/hybrid-scaffolds-of-mg-alloy-mesh-reinforced-polymer-extracellular-matrix-composite-for-critical-sized-calvarial-defect-reconstruction
#7
Yingqi Chen, Sang-Ho Ye, Hideyoshi Sato, Yang Zhu, Vesselin Shanov, Tarannum Tiasha, Antonio D'Amore, Samuel Luketich, Guojiang Wan, William R Wagner
The challenge of developing scaffolds to reconstruct critical-sized calvarial defects without the addition of high levels of exogenous growth factor remains relevant. Both osteogenic regenerative efficacy as well as suitable mechanical properties for the temporary scaffold system are of importance. In this study, a Mg alloy mesh reinforced polymer/demineralized bone matrix (DBM) hybrid scaffold was designed where the hybrid scaffold was fabricated by a concurrent electrospinning/electrospraying of poly(lactic-co-glycolic) (PLGA) polymer and DBM suspended in hyaluronic acid (HA)...
April 20, 2018: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29675859/fabrication-of-superparamagnetic-nanofibrous-poly-l-lactic-acid-%C3%AE-fe-2-o-3-microspheres-for-cell-carriers
#8
Moyuan Qu, Wenqian Xiao, Jiarong Tian, Song Wang, Hong Li, Xue Liu, Xiaoling Yang, Bo Li, Xiaoling Liao
Nanofibrous poly(l-lactic acid) (PLLA) microspheres are extensively studied to be used as cell carriers in the field of tissue engineering because the unique structure can promote cell proliferation and migration. But as injectable scaffold materials, PLLA microspheres easily run off to the soft tissue space because of the lack of cohesive force. It will affect the treatment efficiency and even cause additional inflammatory response. In order to overcome this disadvantage, superparamagnetic γ-Fe2 O3 nanoparticles assisted with oxidative polymerization of dopamine were used for surface modification of PLLA microspheres in this study...
April 19, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29675802/utilization-of-solid-catfish-manure-waste-as-carbon-and-nutrient-source-for-lactic-acid-production
#9
Suan Shi, Jing Li, David M Blersch
The aim of this work was to study the solid waste (manure) produced by catfish as a potential feedstock for the production of lactic acid (LA) via fermentation. The solid waste contains high levels of both carbohydrates and nutrients that are sufficient for LA bacteria. Simultaneous saccharification and co-fermentation (SSCF) was applied using enzyme and Lactobacillus pentosus, and different loadings of enzyme and solid waste were tested. Results showed LA concentrations of 35.7 g/L were obtained at 15% solids content of catfish waste...
April 19, 2018: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29675615/a-modular-approach-for-high-flux-lactic-acid-production-from-methane-in-an-industrial-medium-using-engineered-methylomicrobium-buryatense-5gb1
#10
Shivani Garg, James M Clomburg, Ramon Gonzalez
Convergence of market drivers such as abundant availability of inexpensive natural gas and increasing awareness of its global warming effects have created new opportunities for the development of small-scale gas-to-liquid (GTL) conversion technologies that can efficiently utilize methane, the primary component of natural gas. Leveraging the unique ability of methanotrophs that use methane as carbon and energy source, biological GTL platforms can be envisioned that are readily deployable at remote petroleum drilling sites where large chemical GTL infrastructure is uneconomical to set-up...
April 19, 2018: Journal of Industrial Microbiology & Biotechnology
https://www.readbyqxmd.com/read/29675528/well-dispersed-cellulose-nanocrystals-in-hydrophobic-polymers-by-in-situ-polymerization-for-synthesizing-highly-reinforced-bio-nanocomposites
#11
Shiyu Geng, Jiayuan Wei, Yvonne Aitomäki, Maxime Noël, Kristiina Oksman
In nanocomposites, dispersing hydrophilic nanomaterials in a hydrophobic matrix using simple and environmentally friendly methods remains challenging. Herein, we report a method based on in situ polymerization to synthesize nanocomposites of well-dispersed cellulose nanocrystals (CNCs) and poly(vinyl acetate) (PVAc). We have also shown that by blending this PVAc/CNC nanocomposite with poly(lactic acid) (PLA), a good dispersion of the CNCs can be reached in PLA. The outstanding dispersion of CNCs in both PVAc and PLA/PVAc matrices was shown by different microscopy techniques and was further supported by the mechanical and rheological properties of the composites...
April 20, 2018: Nanoscale
https://www.readbyqxmd.com/read/29675202/%C3%AE-nis-modified-cds-nanowires-for-photocatalytic-h-2-evolution-with-exceptionally-high-efficiency
#12
Shundong Guan, Xiuli Fu, Yu Zhang, Zhijian Peng
Co-catalysis is regarded as a promising strategy to improve the hydrogen evolution performance of semiconductor-based photocatalysts. But developing a simple and effective technique to achieve the optimal synergy between co-catalysts and host photocatalysts has been a great challenge. Herein, hybrid photocatalysts consisting of β-NiS modified CdS nanowires (NiS/CdS NWs) have been synthesized via a simple and green hydrothermal route using CdS NWs as the template from thiourea and nickel acetate in the presence of sodium hypophosphite...
February 14, 2018: Chemical Science
https://www.readbyqxmd.com/read/29674231/photoinduced-peg-deshielding-from-ros-sensitive-linkage-bridged-block-copolymer-based-nanocarriers-for-on-demand-drug-delivery
#13
Jie Li, Chunyang Sun, Wei Tao, Ziyang Cao, Haisheng Qian, Xianzhu Yang, Jun Wang
Controlling poly(ethylene glycol) (PEG) shielding/deshielding at the desired site of action exhibits great advantages for nanocarrier-based on-demand drug delivery in vivo. However, the current PEG deshielding strategies were mainly designed for anticancer drug delivery; even so, their applications are also limited by tumor heterogeneity. As a proof-of-concept, we explored a photoinduced PEG deshielding nanocarrier TK-NPCe6&PTX to circumvent the aforementioned challenge. The TK-NPCe6&PTX encapsulating chlorin e6 (Ce6) and paclitaxel (PTX) was self-assembled from an innovative thioketal (TK) linkage-bridged diblock copolymer of PEG with poly(d,l-lactic acid) (PEG-TK-PLA)...
April 10, 2018: Biomaterials
https://www.readbyqxmd.com/read/29674103/determination-of-the-cell-wall-polysaccharide-and-teichoic-acid-structures-from-lactococcus-lactis-il1403
#14
Evgeny Vinogradov, Irina Sadovskaya, Pascal Courtin, Saulius Kulakauskas, Thierry Grard, Jennifer Mahony, Douwe van Sinderen, Marie-Pierre Chapot-Chartier
In the lactic acid bacterium Lactococcus lactis, a cell wall polysaccharide (CWPS) is the bacterial receptor of the majority of infecting bacteriophages. The diversity of CWPS structures between strains explains, at least partially, the narrow host range of lactococcal phages. In the present work, we studied the polysaccharide components of the cell wall of the prototype L. lactis subsp. lactis strain IL1403. We identified a rhamnose-rich complex polysaccharide, carrying a glycerophosphate substitution, as the major component...
April 12, 2018: Carbohydrate Research
https://www.readbyqxmd.com/read/29674009/corrigendum-to-controlled-release-of-drug-and-better-bioavailability-using-poly-lactic-acid-co-glycolic-acid-nanoparticles-int-j-biol-macromol-89-2016-99-110
#15
Sanjeev K Pandey, Dinesh K Patel, Akhilendra K Maurya, Ravi Thakur, Durga P Mishra, Manjula Vinayak, Chandana Haldar, Pralay Maiti
No abstract text is available yet for this article.
April 16, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29673840/versatile-effects-of-magnesium-hydroxide-nanoparticles-in-plga-scaffold-mediated-chondrogenesis
#16
Kwang-Sook Park, Byoung-Ju Kim, Eugene Lih, Wooram Park, Soo-Hong Lee, Yoon Ki Joung, Dong Keun Han
Artificial scaffolds made up of various synthetic biodegradable polymers have been reported to have many advantages including cheap manufacturing, easy scale up, high mechanical strength, convenient manipulation, and molding into an unlimited variety of shapes. However, the synthetic biodegradable polymers still have the insufficiency for cartilage regeneration owing to their acidic degradation products. To reduce acidification by degradation of synthetic polymers, we incorporated magnesium hydroxide (MH) nanoparticles into porous polymer scaffold not only to effectively neutralize the acidic hydrolysate but also to minimize the structural disturbance of scaffolds...
April 16, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29673790/molecular-detection-and-quantification-of-viable-probiotic-strains-in-animal-feedstuffs-using-the-commercial-direct-fed-microbial-lactobacillus-animalis-np51-as-a-model
#17
D I Ayala, J Chen, M Bugarel, G H Loneragan, H C den Bakker, K R Kottapalli, M M Brashears, K K Nightingale
Lactobacillus animalis NP51 is a direct-fed microbial strain (DFM) extensively used as a pre-harvest food safety mitigation in feedlot cattle due to its antagonistic effects against human foodborne pathogens such as Salmonella and Escherichia coli O157:H7. NP51 not only promotes overall gut health but interferes with the ability of these pathogens to colonize the gastrointestinal tract of cattle. As a result, NP51 reduces fecal shedding of Salmonella and E. coli O157:H7 in cattle presented for harvest and the load of these pathogens that enter the human food chain...
April 16, 2018: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/29673406/inflammatory-mechanism-of-rumenitis-in-dairy-cows-with-subacute-ruminal-acidosis
#18
Chenxu Zhao, Guowen Liu, Xiaobing Li, Yuan Guan, Yazhou Wang, Xue Yuan, Guoquan Sun, Zhe Wang, Xinwei Li
BACKGROUND: Subacute ruminal acidosis (SARA) is a metabolic disease in high-producing dairy cattle, and is accompanied by rumenitis. However, the mechanism of rumenitis remains unclear. Therefore, the aim of this study was to investigate the molecular mechanism of rumenitis in dairy cows with SARA. RESULTS: The results showed that SARA cows displayed high concentrations of ruminal volatile fatty acids, lactic acid and lipopolysaccharide (LPS). Furthermore, the blood concentrations of LPS and acute phase proteins haptoglobin, serum amyloid-A, and LPS binding protein were significantly higher in SARA cows than in control cows...
April 19, 2018: BMC Veterinary Research
https://www.readbyqxmd.com/read/29673188/novel-chlorhexidine-loaded-polymeric-nanoparticles-for-root-canal-treatment
#19
Gina Quiram, Francisco Montagner, Kelli L Palmer, Mihaela C Stefan, Katherine E Washington, Danieli C Rodrigues
Persistence of microorganisms in dentinal tubules after root canal chemo-mechanical preparation has been well documented. The complex anatomy of the root canal and dentinal buffering ability make delivery of antimicrobial agents difficult. This work explores the use of a novel trilayered nanoparticle (TNP) drug delivery system that encapsulates chlorhexidine digluconate, which is aimed at improving the disinfection of the root canal system. Chlorhexidine digluconate was encapsulated inside polymeric self-assembled TNPs...
April 17, 2018: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/29672286/activated-%C3%AE-7nachr-improves-postoperative-cognitive-dysfunction-and-intestinal-injury-induced-by-cardiopulmonary-bypass-in-rats-inhibition-of-the-proinflammatory-response-through-the-th17-immune-response
#20
Keyan Chen, YingJie Sun, Wanwei Dong, Tiezheng Zhang, Nan Zhou, Weiwei Yu, Yugang Diao, Shanbin Guo, Yue Tian
Backgrund/Aims: To investigate the effects of activated α7 nicotinic acetylcholine receptor (α7nAChR) on postoperative cognitive dysfunction (POCD) and intestinal injury induced by cardiopulmonary bypass (CPB) and its relationship with the Th17 response in order to provide a theoretical basis for organ protection and targeted drug therapy during the perioperative period. METHODS: Sprague-Dawley rat models of CPB were established. Rat intestinal and brain injuries were observed after CPB using hematoxylin and eosin staining...
April 16, 2018: Cellular Physiology and Biochemistry
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