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Subthalamic nucleus

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https://www.readbyqxmd.com/read/28548593/bilateral-deep-brain-stimulation-of-the-subthalamic-nucleus-in-primary-meige-syndrome
#1
Shikun Zhan, Fafa Sun, Yixin Pan, Wei Liu, Peng Huang, Chunyan Cao, Jing Zhang, Dianyou Li, Bomin Sun
OBJECTIVE Subthalamic nucleus deep brain stimulation has been shown to be effective in reducing symptoms of primary Meige syndrome. However, assessments of its efficacy and safety have been limited to several case reports and small studies. METHODS The authors performed a retrospective study to assess the efficacy and safety of bilateral subthalamic nucleus stimulation in 15 patients with primary Meige syndrome who responded poorly to medical treatments or botulinum toxin injections. Using the movement and disability subscores of the Burke-Fahn-Marsden Dystonia Rating Scale, the authors evaluated the severity of patients' dystonia and related before surgery and at final follow-up during neurostimulation...
May 26, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28541214/investigating-synchronous-oscillation-and-deep-brain-stimulation-treatment-in-a-model-of-cortico-basal-ganglia-network
#2
Meili Lu, Xile Wei, Kenneth A Loparo
Altered firing properties and increased pathological oscillations in the basal ganglia have been proven to be hallmarks of Parkinson's disease. Increasing evidence suggests that abnormal synchronous oscillations and suppression in the cortex may also play a critical role in the pathogenic process and treatment of Parkinson's disease. In our study, a new closed-loop network including the cortex and basal ganglia using the Izhikevich models is proposed to investigate the synchrony and pathological oscillations in motor circuits and their modulation by deep brain stimulation (DBS)...
May 23, 2017: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://www.readbyqxmd.com/read/28536045/toward-defining-deep-brain-stimulation-targets-in-mni-space-a-subcortical-atlas-based-on-multimodal-mri-histology-and-structural-connectivity
#3
REVIEW
Siobhan Ewert, Philip Plettig, Ningfei Li, Mallar Chakravarty, Louis Collins, Todd Herrington, Andrea Kühn, Andreas Horn
Three-dimensional atlases of subcortical brain structures are valuable tools to reference anatomy in neuroscience and neurology. For instance, they can be used to study the position and shape of the three most common deep brain stimulation (DBS) targets, the subthalamic nucleus (STN), internal part of the pallidum (GPi) and ventral intermediate nucleus of the thalamus (VIM) in stereotactic space and in spatial relationship to DBS electrodes. Here, we present a composite atlas that is based on manual segmentations of a multimodal high resolution brain template, histology and structural connectivity...
May 20, 2017: NeuroImage
https://www.readbyqxmd.com/read/28532905/choreatic-side-effects-of-deep-brain-stimulation-of-the-anteromedial-subthalamic-nucleus-for-treatment-resistant-obsessive-compulsive-disorder-a-case-report
#4
A E P Mulders, A F G Leentjens, K Schruers, A Duits, L Ackermans, Y Temel
BACKGROUND: Patients with treatment-resistant obsessive-compulsive disorder (OCD) are potential candidates for deep brain stimulation (DBS). The anteromedial subthalamic nucleus (STN) is amongst the most commonly used targets for DBS in OCD. CASE DESCRIPTION: We present a patient with a 30-year history of treatment-resistant OCD who underwent anteromedial STN-DBS. Despite a clear mood-enhancing effect, stimulation caused motor side-effects including bilateral hyperkinesia, dyskinesias and sudden large amplitude choreatic movements of arms and legs when stimulating at voltages above circa 1...
May 19, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28531270/utilization-of-quantitative-susceptibility-mapping-for-direct-targeting-of-the-subthalamic-nucleus-during-deep-brain-stimulation-surgery
#5
Jonathan Rasouli, Ritesh Ramdhani, Fedor E Panov, Alexey Dimov, Yan Zhang, Catherine Cho, Yi Wang, Brian Harris Kopell
BACKGROUND: Deep brain stimulation of the subthalamic nucleus (STN) has demonstrated efficacy in improving motor disability in Parkinson's disease. The recently developed quantitative susceptibility mapping (QSM) technique, which can accurately map iron deposits in deep brain nuclei, promises precise targeting of the STN. OBJECTIVE: To demonstrate the use of QSM to target STN effectively by correlating with classical physiological-based targeting measures in a prospective study...
May 21, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/28529870/symptom-specific-amygdala-hyperactivity-modulates-motor-control-network-in-conversion-disorder
#6
Thomas Hassa, Alexandra Sebastian, Joachim Liepert, Cornelius Weiller, Roger Schmidt, Oliver Tüscher
Initial historical accounts as well as recent data suggest that emotion processing is dysfunctional in conversion disorder patients and that this alteration may be the pathomechanistic neurocognitive basis for symptoms in conversion disorder. However, to date evidence of direct interaction of altered negative emotion processing with motor control networks in conversion disorder is still lacking. To specifically study the neural correlates of emotion processing interacting with motor networks we used a task combining emotional and sensorimotor stimuli both separately as well as simultaneously during functional magnetic resonance imaging in a well characterized group of 13 conversion disorder patients with functional hemiparesis and 19 demographically matched healthy controls...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28529730/effect-of-low-versus-high-frequency-stimulation-on-freezing-of-gait-and-other-axial-symptoms-in-parkinson-patients-with-bilateral-stn-dbs-a-mini-review
#7
REVIEW
Tao Xie, Mahesh Padmanaban, Lisa Bloom, Ellen MacCracken, Breanna Bertacchi, Abraham Dachman, Peter Warnke
Some studies have shown that low frequency stimulation (LFS, most commonly 60 Hz), compared to high frequency stimulation (HFS, most commonly 130 Hz), has beneficial effects, short-term or even long-term, on improving freezing of gait (FOG) and other axial symptoms, including speech and swallowing function, in Parkinson disease (PD) patients with bilateral subthalamic nucleus deep brain stimulation (STN DBS). However, other studies failed to confirm this. It seems not clear what determines the difference in response to LFS...
2017: Translational Neurodegeneration
https://www.readbyqxmd.com/read/28526642/-asleep-deep-brain-stimulation-surgery-a-critical-review-of-the-literature
#8
REVIEW
Tsinsue Chen, Zaman Mirzadeh, Francisco A Ponce
OBJECTIVE: Although performing deep brain stimulation (DBS) with the patient under general anesthesia without microelectrode recording (MER) or intraoperative test stimulation (ITS) for movement disorders ("asleep" DBS) has become increasingly popular, its feasibility is based on the untested assumption that stereotactic accuracy correlates with positive clinical outcomes. To investigate outcomes after asleep DBS without MER or neurophysiological testing, we reviewed the medical literature on the topic...
May 16, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28511261/current-practice-and-the-future-of-deep-brain-stimulation-therapy-in-parkinson-s-disease
#9
Leonardo Almeida, Wissam Deeb, Chauncey Spears, Enrico Opri, Rene Molina, Daniel Martinez-Ramirez, Aysegul Gunduz, Christopher W Hess, Michael S Okun
Deep brain stimulation (DBS) is an effective therapy for Parkinson's disease patients experiencing motor fluctuations, medication-resistant tremor, and/or dyskinesia. Currently, the subthalamic nucleus and the globus pallidus internus are the two most widely used targets, with individual advantages and disadvantages influencing patient selection. Potential DBS patients are selected using the few existing guidelines and the available DBS literature, and many centers employ an interdisciplinary team review of the individual's risk-benefit profile...
April 2017: Seminars in Neurology
https://www.readbyqxmd.com/read/28511125/the-many-facets-of-motor-learning-and-their-relevance-for-parkinson-s-disease
#10
REVIEW
Lucio Marinelli, Angelo Quartarone, Mark Hallett, Giuseppe Frazzitta, Maria Felice Ghilardi
The final goal of motor learning, a complex process that includes both implicit and explicit (or declarative) components, is the optimization and automatization of motor skills. Motor learning involves different neural networks and neurotransmitters systems depending on the type of task and on the stage of learning. After the first phase of acquisition, a motor skill goes through consolidation (i.e., becoming resistant to interference) and retention, processes in which sleep and long-term potentiation seem to play important roles...
April 9, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/28504352/optimizing-psychosocial-adjustment-after-deep-brain-stimulation-of-the-subthalamic-nucleus-in-parkinson-s-disease
#11
Suzette Shahmoon, Marjan Jahanshahi
No abstract text is available yet for this article.
May 15, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28504196/human-subthalamic-nucleus-automatic-auditory-change-detection-as-a-basis-for-action-selection
#12
Marcus Heldmann, Thomas F Münte, Lejla Paracka, Frederike Beyer, Norbert Brüggemann, Assel Saryyeva, Dirk Rasche, Joachim K Krauss, Volker M Tronnier
The subthalamic nucleus (STN) shapes motor behavior and is important for the initiation and termination of movements. Here we ask whether the STN takes aggregated sensory information into account, in order to exert this function. To this end, local field potentials (LFP) were recorded in eight patients suffering from Parkinson's disease and receiving deep-brain stimulation of the STN bilaterally. Bipolar recordings were obtained postoperatively from the externalized electrode leads. Patients were passively exposed to trains of auditory stimuli containing global deviants, local deviants or combined global/local deviants...
May 11, 2017: Neuroscience
https://www.readbyqxmd.com/read/28497554/shaking-up-the-debate-ensuring-the-ethical-use-of-dbs-intervention-criteria-for-mid-stage-parkinson-s-patients
#13
REVIEW
Marleen Eijkholt, Laura Y Cabrera, Adolfo Ramirez-Zamora, Julie G Pilitsis
OBJECTIVES: Deep brain stimulation (DBS) is a well-established treatment for the management of severe motor fluctuations in advanced Parkinson's disease (PD). Until recently, device regulation, medical, and insurance practices limited DBS to patients with advanced stages of PD. In February 2016 this changed, however, when the US Food and Drug Administration (FDA) granted formal approval for the use of brain stimulator in mid-stage PD patients. In this article, we examine whether DBS in mid-stage PD can be ethically justified beyond the FDA approval...
May 11, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/28494345/weight-gain-after-stn-dbs-the-role-of-reward-sensitivity-and-impulsivity
#14
Marilena Aiello, Roberto Eleopra, Francesco Foroni, Sara Rinaldo, Raffaella I Rumiati
Weight gain has been reported after deep brain stimulation of the subthalamic nucleus (STN-DBS), a widely used treatment for Parkinson's disease (PD). This nucleus has been repeatedly found to be linked both to reward and to inhibitory control, two key aspects in the control of food intake. In this study, we assessed whether weight gain experienced by patients with PD after STN-DBS, might be due to an alteration of reward and inhibitory functions. Eighteen patients with PD were compared to eighteen healthy controls and tested three times: before surgery, in ON medication and after surgery, respectively five days after the implantation in ON medication/OFF stimulation and at least three months after surgery in ON medication/ON stimulation...
April 21, 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/28493348/effect-of-eye-opening-on-single-unit-activity-and-local-field-potentials-in-the-subthalamic-nucleus
#15
Arun Chockalingam, Abigail Belasen, Nita Chen, Adolfo Ramirez-Zamora, Youngwon Youn, Paul Feustel, Meghan E Wilock, Damian S Shin, Julie G Pilitsis
BACKGROUND: Subthalamic nucleus deep brain stimulation (STN DBS) is an established treatment in Parkinson's disease (PD). We investigate the effect of eye opening on neuronal activity and local field potentials (LFPs) in the STN. METHODS: We prospectively enrolled 25 PD patients undergoing STN DBS in our institution. During DBS, single-unit activity (SUA) and LFPs were measured when eyes were open and closed. As movement is known to result in changes in LFPs, we tested response to eye opening in the presence and absence of movement...
May 10, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/28492384/effect-of-dexmedetomidine-and-propofol-on-basal-ganglia-activity-in-parkinson-disease-a-controlled-clinical-trial
#16
Antonio Martinez-Simon, Manuel Alegre, Cristina Honorato-Cia, Jorge M Nuñez-Cordoba, Elena Cacho-Asenjo, Iñaki F Trocóniz, Mar Carmona-Abellán, Miguel Valencia, Jorge Guridi
BACKGROUND: Deep brain stimulation electrodes can record oscillatory activity from deep brain structures, known as local field potentials. The authors' objective was to evaluate and quantify the effects of dexmedetomidine (0.2 μg·kg·h) on local field potentials in patients with Parkinson disease undergoing deep brain stimulation surgery compared with control recording (primary outcome), as well as the effect of propofol at different estimated peak effect site concentrations (0.5, 1...
April 7, 2017: Anesthesiology
https://www.readbyqxmd.com/read/28491942/a-dataset-of-multi-contrast-population-averaged-brain-mri-atlases-of-a-parkinson-s-disease-cohort
#17
Yiming Xiao, Vladimir Fonov, M Mallar Chakravarty, Silvain Beriault, Fahd Al Subaie, Abbas Sadikot, G Bruce Pike, Gilles Bertrand, D Louis Collins
Parkinson׳s disease (PD) is a neurodegenerative disease that primarily affects the motor functions of the patients. Research and surgical treatment of PD (e.g., deep brain stimulation) often require human brain atlases for structural identification or as references for anatomical normalization. However, two pitfalls exist for many current atlases used for PD. First, most atlases do not represent the disease-specific anatomy as they are based on healthy young subjects. Second, subcortical structures, such as the subthalamic nucleus (STN) used in deep brain stimulation procedures, are often not well visualized...
June 2017: Data in Brief
https://www.readbyqxmd.com/read/28489140/different-outcomes-of-phonemic-verbal-fluency-in-parkinson-s-disease-patients-with-subthalamic-nucleus-deep-brain-stimulation
#18
Aline Juliane Romann, Bárbara Costa Beber, Maira Rozenfeld Olchik, Carlos R M Rieder
Subthalamic nucleus deep brain stimulation (STN-DBS) is a surgical technique to treat motor symptoms in patients with Parkinson's disease (PD). Studies have shown that STN-DBS may cause a decline in verbal fluency performance. We aimed to verify the effects of STN-DBS on the performance of phonemic verbal fluency in Brazilian PD patients. Sixteen participants were evaluated on the Unified Parkinson's Disease Rating Scale - Part III and for phonemic fluency ("FAS" version) in the conditions of on- and off-stimulation...
April 2017: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/28480753/bibliometric-profile-of-deep-brain-stimulation
#19
Kejia Hu, Ziev B Moses, Wendong Xu, Ziv Williams
OBJECTIVE: We aimed to identify and analyze the characteristics of the 100 most highly-cited papers in the research field of deep brain stimulation (DBS). METHODS: The Web of Science was searched for highly-cited papers related to DBS research. The number of citations, countries, institutions of origin, year of publication, and research area were noted and analyzed. RESULTS: The 100 most highly-cited articles had a mean of 304.15 citations...
May 8, 2017: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/28480524/stratifying-parkinson-s-patients-with-stn-dbs-into-high-frequency-or-60-hz-frequency-modulation-using-a-computational-model
#20
Anahita Khojandi, Oleg Shylo, Lucia Mannini, Brian H Kopell, Ritesh A Ramdhani
OBJECTIVE: High frequency stimulation (HFS) of the subthalamic nucleus (STN) is a well-established therapy for Parkinson's disease (PD), particularly the cardinal motor symptoms and levodopa induced motor complications. Recent studies have suggested the possible role of 60 Hz stimulation in STN-deep brain stimulation (DBS) for patients with gait disorder. The objective of this study was to develop a computational model, which stratifies patients a priori based on symptomatology into different frequency settings (i...
May 8, 2017: Neuromodulation: Journal of the International Neuromodulation Society
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