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Subthalamic nucleus

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https://www.readbyqxmd.com/read/29053865/beta-burst-dynamics-in-parkinson-s-disease-off-and-on-dopaminergic-medication
#1
Gerd Tinkhauser, Alek Pogosyan, Huiling Tan, Damian M Herz, Andrea A Kühn, Peter Brown
Exaggerated basal ganglia beta activity (13-35 Hz) is commonly found in patients with Parkinson's disease and can be suppressed by dopaminergic medication, with the degree of suppression being correlated with the improvement in motor symptoms. Importantly, beta activity is not continuously elevated, but fluctuates to give beta bursts. The percentage number of longer beta bursts in a given interval is positively correlated with clinical impairment in Parkinson's disease patients. Here we determine whether the characteristics of beta bursts are dependent on dopaminergic state...
October 10, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29053638/neuroprotective-surgical-strategies-in-parkinson-s-disease-role-of-preclinical-data
#2
REVIEW
Napoleon Torres, Jenny Molet, Cecile Moro, John Mitrofanis, Alim Louis Benabid
Although there have been many pharmacological agents considered to be neuroprotective therapy in Parkinson's disease (PD) patients, neurosurgical approaches aimed to neuroprotect or restore the degenerative nigrostriatal system have rarely been the focus of in depth reviews. Here, we explore the neuroprotective strategies involving invasive surgical approaches (NSI) using neurotoxic models 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 6-hydroxydopamine (6-OHDA), which have led to clinical trials. We focus on several NSI approaches, namely deep brain stimulation of the subthalamic nucleus, glial neurotrophic derived factor (GDNF) administration and cell grafting methods...
October 20, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29051496/evidence-for-a-task-dependent-switch-in-subthalamo-nigral-basal-ganglia-signaling
#3
Jay J Jantz, Masayuki Watanabe, Ron Levy, Douglas P Munoz
Basal ganglia (BG) can either facilitate or inhibit movement through excitatory and inhibitory pathways; however whether these opposing signals are dynamically regulated during healthy behavior is not known. Here, we present compelling neurophysiological evidence from three complimentary experiments in non-human primates, indicating task-specific changes in tonic BG pathway weightings during saccade behavior with different cognitive demands. First, simultaneous local field potential recording in the subthalamic nucleus (STN; BG input) and substantia nigra pars reticulata (SNr; BG output) reveals task-dependent shifts in subthalamo-nigral signals...
October 19, 2017: Nature Communications
https://www.readbyqxmd.com/read/29050378/reply-oscillatory-coupling-of-the-subthalamic-nucleus-in-obsessive-compulsive-disorder
#4
Ettore A Accolla, Andreas Horn, Maria Herrojo-Ruiz, Wolf-Julian Neumann, Andrea A Kühn
No abstract text is available yet for this article.
September 1, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29050377/oscillatory-coupling-of-the-subthalamic-nucleus-in-obsessive-compulsive-disorder
#5
Lars Wojtecki, Jan Hirschmann, Saskia Elben, Matthias Boschheidgen, Carlos Trenado, Jan Vesper, Alfons Schnitzler
No abstract text is available yet for this article.
September 1, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29048606/contact-location-and-neuropsychological-outcomes-in-subthalamic-deep-brain-stimulation
#6
Darlene P Floden, Caio M Matias, Connor A Wathen, Grace E Ozinga, Olivia Hogue, Andre G Machado
BACKGROUND: A host of influences contribute to cognitive and behavioral changes following deep brain stimulation. The location of the active cathode is likely an important variable but it has received little attention. OBJECTIVE: To determine whether active contact location relative to the subthalamic nucleus and other neighboring structures is related to nonmotor outcomes. METHODS: We identified a retrospective, cross-sectional sample of 46 patients who underwent subthalamic nucleus deep brain stimulation for treatment of idiopathic Parkinson's disease...
October 18, 2017: Neurosurgery
https://www.readbyqxmd.com/read/29044874/information-processing-from-the-motor-cortices-to-the-subthalamic-nucleus-and-globus-pallidus-and-their-somatotopic-organizations-revealed-electrophysiologically-in-monkeys
#7
Hirokazu Iwamuro, Yoshihisa Tachibana, Yoshikazu Ugawa, Nobuhito Saito, Atsushi Nambu
To understand how the information derived from different motor cortical areas representing different body parts is organized in the basal ganglia, we examined the neuronal responses in the subthalamic nucleus (STN), and the external (GPe) and internal (GPi) segments of the globus pallidus, input, relay, and output nuclei, respectively, to stimulation of the orofacial, forelimb, and hindlimb regions of the primary motor cortex (MI) and supplementary motor area (SMA) in macaque monkeys under awake state. Most STN and GPe/GPi neurons responded exclusively to stimulation of either the MI or SMA, and one-fourth to one-third of neurons responded to both...
October 17, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/29038241/sensorimotor-processing-in-the-basal-ganglia-leads-to-transient-beta-oscillations-during-behavior
#8
Amin Mirzaei, Arvind Kumar, Daniel Leventhal, Nicolas Mallet, Ad Aertsen, Joshua Berke, Robert Schmidt
Brief epochs of beta oscillations have been implicated in sensorimotor control in the basal ganglia of task-performing healthy animals. However, which neural processes underlie their generation and how they are affected by sensorimotor processing remains unclear. To determine the mechanisms underlying transient beta oscillations in the local field potential (LFP), we combined computational modeling of the subthalamo-pallidal network for the generation of beta oscillations with realistic stimulation patterns derived from single unit data...
October 16, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29034586/avoiding-internal-capsule-stimulation-with-a-new-eight-channel-steering-deep-brain-stimulation-lead
#9
Kees J van Dijk, Rens Verhagen, Lo J Bour, Ciska Heida, Peter H Veltink
OBJECTIVE: Novel deep brain stimulation (DBS) lead designs are currently entering the market, which are hypothesized to provide a way to steer the stimulation field away from neural populations responsible for side effects and towards populations responsible for beneficial effects. The objective of this study is to assess the performances of a new eight channel steering-DBS lead and compare this with a conventional cylindrical contact (CC) lead. APPROACH: The two leads were evaluated in a finite element electric field model combined with multicompartment neuron and axon models, representing the internal capsule (IC) fibers and subthalamic nucleus (STN) cells...
October 15, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/29033800/stimulation-of-cortico-subthalamic-projections-amplifies-resting-motor-circuit-activity-and-leads-to-increased-locomotion-in-dopamine-depleted-mice
#10
Teresa H Sanders
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) improves motor function in patients with Parkinson's disease (PD). STN-DBS enables similar improved motor function, including increased movement speed (reduced bradykinesia), in the 6-OHDA dopamine-depletion mouse model of PD. Previous analyses of electrophysiological recordings from STN and motor cortex (M1) have explored signaling changes that correspond to PD and amelioration of PD symptoms. The most common results show an increase in beta frequency power during 'off' states and a reduction in beta during 'on' states...
2017: Frontiers in Integrative Neuroscience
https://www.readbyqxmd.com/read/29032347/vocalic-transitions-as-markers-of-speech-acoustic-changes-with-stn-dbs-in-parkinson-s-disease
#11
Vincent Martel-Sauvageau, Kris Tjaden
PURPOSE: Deep Brain Stimulation of the subthalamic nucleus (STN-DBS) effectively treats cardinal symptoms of idiopathic Parkinson's disease (PD) that cannot be satisfactorily managed with medication. Research is equivocal regarding speech changes associated with STN-DBS. This study investigated the impact of STN-DBS on vocalic transitions and the relationship to intelligibility. METHODS: Eight Quebec-French speakers with PD and eight healthy controls participated...
October 7, 2017: Journal of Communication Disorders
https://www.readbyqxmd.com/read/29020291/reward-sensitivity-and-waiting-impulsivity-shift-towards-reward-valuation-away-from-action-control
#12
Daisy J Mechelmans, Daniela Strelchuk, Nuria Donamayor-Alonso, Paula Banca, Trevor W Robbins, Kwangyeol Baek, Valerie Voon
Background: Impulsivity and reward expectancy are commonly inter-related. Waiting impulsivity, measured using the rodent 5-Choice Serial Reaction Time (5-CSRT) task, predicts compulsive cocaine seeking and sign (or cue) tracking. Here we assess human waiting impulsivity using a novel translational task, the 4-CSRT, and the relationship with reward cues. Methods: Healthy volunteers (n=29) performed the monetary incentive delay task as a functional MRI study where subjects observe a cue predicting reward (cue) and wait to respond for high (£5), low (£1) or no reward...
August 8, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28991693/magnetic-resonance-and-computed-tomography-image-fusion-technology-in-patients-with-parkinson-s-disease-after-deep-brain-stimulation
#13
Jun Xia, Pin He, Xiaodong Cai, Doudou Zhang, Ni Xie
Electrode position after deep brain stimulation (DBS) for Parkinson's disease (PD) needs to be confirmed, but there are concerns about the risk of postoperative magnetic resonance imaging (MRI) after DBS. These issues could be avoided by fusion images obtained from preoperative MRI and postoperative computed tomography (CT). This study aimed to investigate image fusion technology for displaying the position of the electrodes compared with postoperative MRI. This was a retrospective study of 32 patients with PD treated with bilateral subthalamic nucleus (STN) DBS between April 2015 and March 2016...
October 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28988390/topographic-distribution-of-brain-iron-deposition-and-small-cerebrovascular-lesions-in-amyotrophic-lateral-sclerosis-and-in-frontotemporal-lobar-degeneration-a-post-mortem-7-0-tesla-magnetic-resonance-imaging-study-with-neuropathological-correlates
#14
Jacques De Reuck, David Devos, Caroline Moreau, Florent Auger, Nicolas Durieux, Vincent Deramecourt, Florence Pasquier, Claude-Alain Maurage, Charlotte Cordonnier, Didier Leys, Regis Bordet
Amyotrophic lateral sclerosis (ALS) is associated with frontotemporal lobar degeneration (FTLD) in 15% of the cases. A neuropathological continuity between ALS and FTLD-TDP is suspected. The present post-mortem 7.0-tesla magnetic resonance imaging (MRI) study compares the topographic distribution of iron (Fe) deposition and the incidence of small cerebrovascular lesions in ALS and in FTLD brains. Seventy-eight post-mortem brains underwent 7.0-tesla MRI. The patients consisted of 12 with ALS, 38 with FTLD, and 28 controls...
October 7, 2017: Acta Neurologica Belgica
https://www.readbyqxmd.com/read/28986718/frontal-lobe-connectivity-and-network-community-characteristics-are%C3%A2-associated-with-the-outcome-of-subthalamic-nucleus-deep-brain-stimulation-in-patients-with-parkinson-s-disease
#15
Nabin Koirala, Vinzenz Fleischer, Martin Glaser, Kirsten E Zeuner, Günther Deuschl, Jens Volkmann, Muthuraman Muthuraman, Sergiu Groppa
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is nowadays an evidence-based state of the art therapy option for motor and non-motor symptoms in patients with Parkinson's disease (PD). However, the exact anatomical regions of the cerebral network that are targeted by STN-DBS have not been precisely described and no definitive pre-intervention predictors of the clinical response exist. In this study, we test the hypothesis that the clinical effectiveness of STN-DBS depends on the connectivity profile of the targeted brain networks...
October 6, 2017: Brain Topography
https://www.readbyqxmd.com/read/28985717/identification-of-vps35-p-d620n-mutation-related-parkinson-s-disease-in-a-taiwanese-family-with-successful-bilateral-subthalamic-nucleus-deep-brain-stimulation-a-case-report-and-literature-review
#16
Ying-Fa Chen, Yung-Yee Chang, Min-Yu Lan, Pei-Lung Chen, Chin-Hsien Lin
BACKGROUND: Vacuolar protein sorting 35 (VPS35) was recently reported to be a genetic cause for late-onset autosomal dominant Parkinson's disease (PD). However, VPS35 mutations are rarely reported in Asian populations. Herein, we report the first Taiwanese family with the pathogenic VPS35 p.D620N mutation, including one patient treated successfully with subthalamic nucleus deep brain stimulation (STN-DBS). CASE PRESENTATION: A 61-year-old woman presented with progressive left hand resting tremor at the age of 42...
October 6, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28985419/subthalamic-nucleus-stimulation-impairs-emotional-conflict-adaptation-in-parkinson-s-disease
#17
Friederike Irmen, Julius Huebl, Henning Schroll, Christof Brücke, Gerd-Helge Schneider, Fred H Hamker, Andrea A Kühn
The subthalamic nucleus (STN) occupies a strategic position in the motor network, slowing down responses in situations with conflicting perceptual input. Recent evidence suggests a role of the STN in emotion processing through strong connections with emotion recognition structures. As deep brain stimulation (DBS) of the STN in patients with Parkinson's disease (PD) inhibits monitoring of perceptual and value-based conflict, STN DBS may also interfere with emotional conflict processing. To assess a possible interference of STN DBS with emotional conflict processing, we used an emotional Stroop paradigm...
July 11, 2017: Social Cognitive and Affective Neuroscience
https://www.readbyqxmd.com/read/28983444/vibrotactile-coordinated-reset-stimulation-for-the-treatment-of-neurological-diseases-concepts-and-device-specifications
#18
Peter A Tass
Coordinated reset stimulation (CRS) consists of spatiotemporal sequences of stimuli delivered to different sites in the brain. Computationally, it was shown that by achieving an unlearning of abnormal synaptic connectivity, CRS can cause a long-lasting reduction of pathological synchronization, a hallmark feature of Parkinson's disease and other brain disorders. Pre-clinical and proof of concept clinical studies in parkinsonian monkeys and patients showed that CRS applied through deep brain stimulation electrodes implanted in the subthalamic nucleus resulted in cumulative and long-lasting therapeutic effects along with a reduction of beta band oscillations...
August 2, 2017: Curēus
https://www.readbyqxmd.com/read/28982612/brain-regional-iron-contents-in-progressive-supranuclear-palsy
#19
Seung Ha Lee, Chul Hyoung Lyoo, Sung Jun Ahn, Juha O Rinne, Myung Sik Lee
INTRODUCTION: To determine motor-related brain regions in which iron contents correlate with the degree of motor deficits of progressive supranuclear palsy (PSP). METHODS: Twenty-four patients with probable PSP and 20 controls were included. Using a 3.0T magnetic resonance imaging scanner, R2* values were measured in the putamen, globus pallidus (GP), substantia nigra (SN), subthalamic nucleus, and dentate nucleus. After adjustment for disease duration and age at examination, correlations between regional brain R2* values and Unified Parkinson Disease Rating Scale (UPDRS) total motor scores or subscores for bradykinesia, rigidity, tremor, or axial motor deficits were investigated...
September 28, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28982098/the-relationship-of-electrophysiologic-subthalamic-nucleus-length-as-a-predictor-of-outcomes-in-deep-brain-stimulation-for-parkinson-disease
#20
Mahesh B Shenai, Daxa M Patel, Andrew Romeo, J Dylan Whisenhunt, Harrison C Walker, Stephanie Guthrie, Barton L Guthrie
BACKGROUND: Intraoperative measurement of subthalamic nucleus (STN) width through microelectrode recording (MER) is a common proxy for optimal electrode location during deep brain stimulation (DBS) surgery for Parkinson disease. We assessed whether the MER-determined STN width is a predictor of postoperative Unified Parkinson Disease Rating Scale (UPDRS) improvement. METHODS: Records were reviewed for patients who underwent single-sided STN DBS placement for Parkinson disease between 2005 and 2010 at the UAB Medical Center...
October 6, 2017: Stereotactic and Functional Neurosurgery
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