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https://www.readbyqxmd.com/read/29236379/alcohol-consumption-and-low-risk-drinking-guidelines-among-adults-a-cross-sectional-analysis-from-alberta-s-tomorrow-project
#1
Darren R Brenner, Tiffany R Haig, Abbey E Poirier, Alianu Akawung, Christine M Friedenreich, Paula J Robson
INTRODUCTION: Moderate to heavy alcohol consumption is a risk factor for all-cause mortality and cancer incidence. Although cross-sectional data are available through national surveys, data on alcohol consumption in Alberta from a large prospective cohort were not previously available. The goal of these analyses was to characterize the levels of alcohol consumption among adults from the Alberta's Tomorrow Project in the context of cancer prevention guidelines. Furthermore, we conducted analyses to examine the relationships between alcohol consumption and other high-risk or risk-related behaviours...
December 2017: Health Promotion and Chronic Disease Prevention in Canada
https://www.readbyqxmd.com/read/29236378/urinary-bisphenol-a-and-obesity-in-adults-results-from-the-canadian-health-measures-survey
#2
Minh T Do, Vicky C Chang, Michelle A Mendez, Margaret de Groh
INTRODUCTION: Exposure to bisphenol A (BPA) has been shown to affect lipid metabolism and promote weight gain in animal studies. Recent epidemiological studies also support a link between BPA and obesity in human populations, although many were limited to a single adiposity measure or have not considered potential confounding by dietary factors. The purpose of this study is to examine associations between urinary BPA and adiposity measures in a nationally representative sample of Canadian adults...
December 2017: Health Promotion and Chronic Disease Prevention in Canada
https://www.readbyqxmd.com/read/29236377/xpey-relational-environments-an-analytic-framework-for-conceptualizing-indigenous-health-equity
#3
Alexandra Kent, Charlotte Loppie, Jeannine Carriere, Marjorie MacDonald, Bernie Pauly
INTRODUCTION: Both health equity research and Indigenous health research are driven by the goal of promoting equitable health outcomes among marginalized and underserved populations. However, the two fields often operate independently, without collaboration. As a result, Indigenous populations are underrepresented in health equity research relative to the disproportionate burden of health inequities they experience. In this methodological article, we present Xpey' Relational Environments, an analytic framework that maps some of the barriers and facilitators to health equity for Indigenous peoples...
December 2017: Health Promotion and Chronic Disease Prevention in Canada
https://www.readbyqxmd.com/read/29236355/b-cell-specific-protein-fcrla-is-expressed-by-plasmacytoid-dendritic-cells-in-humans
#4
Evdokiya Reshetnikova, Sergey Guselnikov, Olga Volkova, Konstantin Baranov, Alexander Taranin, Ludmila Mechetina
BACKGROUND: Fc receptor-like A (FCRLA) is a unique member of a family of Fc receptor like-molecules that lacks a transmembrane region and is an ER-resident protein. In mice and humans, FCRLA has been known as a B cell specific protein. We report here that, in humans, FCRLA is also expressed in a subpopulation of plasmacytoid dendritic cells (pDCs). METHODS: Human peripheral blood mononuclear cells (PBMC), splenocytes, and tonsillar cells were stained for lineage markers followed by fixation/saponin permeabilization and intracellular staining for FCRLA, and then analyzed by flow cytometry with CD123 and CD303 used as pDC markers...
December 13, 2017: Cytometry. Part B, Clinical Cytometry
https://www.readbyqxmd.com/read/29236352/iccs-escca-consensus-guidelines-for-the-clinical-utility-of-testing-for-gpi-anchor-deficient-clones-in-paroxysmal-nocturnal-hemoglobinuria-pnh-and-other-bone-marrow-disorders-part-1
#5
Amy E Dezern, Michael J Borowitz
Paroxysmal nocturnal hemoglobinuria (PNH) arises as a consequence of the non-malignant clonal expansion of one or more hematopoietic stem cells with an acquired somatic mutation of the PIGA gene.(1) Progeny of affected stem cells are deficient in glycosyl phosphatidylinositol-anchored proteins (GPI-APs). This deficiency is readily detected by flow cytometry. Though this seems straightforward, the clinical utility of this testing requires that the ordering clinician understand not only the characteristics of the test, but also the biology of the underlying disease, and the clinical and laboratory manifestations in the individual patient...
December 13, 2017: Cytometry. Part B, Clinical Cytometry
https://www.readbyqxmd.com/read/29236334/post-transfusional-changes-in-serum-hepcidin-and-iron-parameters-in-preterm-infants
#6
Fotini Stripeli, John Kapetanakis, Dimitris Gourgiotis, Antonis Drakatos, Maria Tsolia, Lydia Kossiva
BACKGROUND: Packed red blood cells (PRBCs) transfusions are common in preterm neonates. Hepcidin acts as a negative feedback iron regulator. Iron parameters such as immature reticulocyte fraction (IRF) and high light scatter reticulocytes (HLR) are used to clarify iron metabolism. Very little is known about the regulation of hepcidin in the preterms as most of reports evaluated the prohepcidin. The aim of the study was to evaluate serum hepcidin and established hematological parameters in preterms after the transfusion...
December 13, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/29236313/micrornas-and-exosomes-in-depression-potential-diagnostic-biomarkers
#7
Jahanshir Tavakolizadeh, Kambiz Roshanaei, Arash Salmaninejad, Reza Yari, Javid Sadri Nahand, Hoda Khoshdel Sarkarizi, Seyed Mojtaba Mousavi, Reza Salarinia, Majid Rahmati, Seyed Farshid Mousavi, Ryan Mokhtari, Hamed Mirzaei
Depression is known as one of important psychiatric disorders which could be associated with disability among various populations. Diagnostic and statistical manual of mental disorders, 4th edition (DSM-IV) and international statistical classification of diseases and related health problems (ICD-10) could be used as subjective diagnostic schemes for identification of mental disorders such as depression. Utilization of subjective diagnostic schemes are associated with limitations. Hence, it seems that employing of new diagnosis platforms is required...
December 13, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29236307/interleukin-4-induces-a-cd44high-cd49bhigh-pc3-subpopulation-with-tumor-initiating-characteristics
#8
Holger H H Erb, Fabian Guggenberger, Frédéric R Santer, Zoran Culig
Pro- and anti-inflammatory cytokines may influence proliferation, migration, invasion and other cellular events of prostate cancer (PCa) cells. The hyaluronan receptor CD44, which is regulated by Interleukin (IL)-4, is a prostate basal cell marker. CD44high /CD49bhigh expressing cells have been demonstrated to have tumor-initiating characteristics. Here, we aimed to analyze the effects of long-term IL-4 treatment on CD44/CD49b expression, migration, proliferation and clonogenic potential of basal-like PCa cells...
December 13, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29236294/acute-myeloid-leukemia-and-myelodysplastic-syndrome-after-adjuvant-chemotherapy-a-population-based-study-among-older-breast-cancer-patients
#9
Aron S Rosenstock, Jiangong Niu, Sharon H Giordano, Hui Zhao, Antonio C Wolff, Mariana Chavez-MacGregor
BACKGROUND: Chemotherapy for early breast cancer is associated with a small risk of developing myelodysplastic syndrome (MDS) and/or acute myeloid leukemia (AML). The aim of this study was to determine the risk of developing AML or MDS after modern adjuvant chemotherapy in older breast cancer patients and to further define the risk of individual chemotherapy regimens. METHODS: Patients diagnosed with stage I to III breast cancer from 2003 to 2009 were identified in the Surveillance, Epidemiology, and End Results-Medicare and Texas Cancer Registry-Medicare linked databases...
December 13, 2017: Cancer
https://www.readbyqxmd.com/read/29236281/preoperative-evaluation-and-intraoperative-protection-of-the-facial-nerve-in-congenital-aural-atresia
#10
Jie Li, Shouqin Zhao, Lin Yang, Yi Li, Xiaobo Ma, Danni Wang, Ran Ren, Ying Li
We conducted a prospective study to assess the value of high-resolution computed tomography (HRCT) in identifying facial nerve variations in patients with congenital aural atresia and to determine how they affect otologic reconstruction surgery. Our study population was made up of 65 patients (69 ears) aged 6 to 22 years (mean: 13.7) without regard to sex. They were classified into three groups according to their scores on the Jahrsdoerfer grading scale: 46 ears scored 8 or more, 18 had a score of 6 or 7, and 5 scored 5 or less...
December 2017: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/29236278/head-and-neck-surgical-reconstruction-in-operation-iraqi-freedom-and-operation-enduring-freedom-afghanistan-a-systematic-review
#11
Samantha J Mikals, Joshua M Jabaut, Art A Ambrosio
Historically, head and neck injuries constituted 16 to 20% of all nonfatal combat injuries. However, advances in body and vehicle armor in the context of the use of ambushes and improvised explosive devices by enemy combatants have resulted in fewer fatalities from head and neck wounds, and thus the incidence of nonfatal head and neck injuries has risen to as high as 52%. Despite this increase, data regarding specific injury distributions, surgical cases, and approaches to repair are lacking in the current literature...
December 2017: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/29236274/outcomes-of-adenotonsillectomy-in-severe-pediatric-obstructive-sleep-apnea
#12
Karim El-Kersh, Rodrigo Cavallazzi, Egambaram Senthilvel
We conducted a retrospective chart review to examine the efficacy of adenotonsillectomy for the treatment of severe obstructive sleep apnea (OSA) in children. Our study population was made up of 85 patients-58 boys and 27 girls, aged 1 to 17 years (mean: 6.9 ± 4.4)-with severe OSA who had undergone adenotonsillectomy and pre- and postoperative attended polysomnography (PSG) over a 4-year period. Severe OSA was defined as an apnea-hypopnea index (AHI) of >10 events per hour of sleep. Patients who had an underlying genetic or craniofacial anomaly were excluded...
December 2017: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/29236250/measuring-mrna-decay-in-budding-yeast-using-single-molecule-fish
#13
Tatjana Trcek, Samir Rahman, Daniel Zenklusen
Cellular mRNA levels are determined by the rates of mRNA synthesis and mRNA decay. Typically, mRNA degradation kinetics are measured on a population of cells that are either chemically treated or genetically engineered to inhibit transcription. However, these manipulations can affect the mRNA decay process itself by inhibiting regulatory mechanisms that govern mRNA degradation, especially if they occur on short time-scales. Recently, single molecule fluorescent in situ hybridization (smFISH) approaches have been implemented to quantify mRNA decay rates in single, unperturbed cells...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29236248/determining-mrna-decay-rates-using-rna-approach-to-equilibrium-sequencing-rate-seq
#14
Farah Abdul-Rahman, David Gresham
RATE-seq is a 4-thiouracil (4-tU)-based method that enables the in vivo measurement of transcriptome-wide RNA degradation rates. 4-tU is an analog of uracil that is rapidly incorporated into newly synthesized RNA and facilitates the conjugation of a biotinylated molecule containing a reactive thiol group. The biotinylated RNA can then be fractionated from the unlabeled RNA with streptavidin magnetic beads. By adding 4-tU to a culture of cells growing in steady-state conditions, fractionating the labeled population of RNA at multiple time points following 4-tU addition, and quantifying the abundance of newly transcribed RNAs using RNAseq, it is possible to estimate the degradation rates of all transcripts in a single experiment...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29236239/abdominal-aorta-and-pelvic-artery-calcifications-on-plain-radiographs-may-predict-mortality-in-chronic-kidney-disease-hemodialysis-and-renal-transplantation
#15
Sinee Disthabanchong, Kotcharat Vipattawat, Bunyong Phakdeekitcharoen, Chagriya Kitiyakara, Vasant Sumethkul
PURPOSE: Vascular calcification is common in chronic kidney disease (CKD) and predicts poor patient outcomes. While computed tomography is the gold standard for evaluation of vascular calcification, plain radiograph offers a simpler and less costly alternative. The calcification of abdominal aorta, iliac and femoral arteries has been evaluated by plain radiograph, but the data on their outcome predictabilities are still limited. The present study investigated the role of abdominal aortic calcification (AAC) and pelvic arterial calcification (PAC) in predicting overall morality in non-dialysis CKD stages 2-5 (CKD 2-5), maintenance hemodialysis (HD) and long-term kidney transplant (KT) patients...
December 13, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/29236228/population-pharmacokinetic-pharmacodynamic-modeling-of-ropivacaine-in-spinal-anesthesia
#16
Zoubir Djerada, Catherine Feliu, Yoann Cazaubon, Faouzi Smati, Philippe Gomis, Dominique Guerrot, Beny Charbit, Olivier Fernandes, Jean-Marc Malinovsky
BACKGROUND: Ropivacaine is frequently used in spinal anesthesia but the relationship between plasma concentrations and sensory block level remains unknown. OBJECTIVE: The aim of this study was to assess the relationship between plasma ropivacaine concentrations and effects during spinal anesthesia. METHODS: Sixty patients aged between 18 and 82 years were included in this study after providing written informed consent. Patients were randomly assigned to receive intrathecal administration of ropivacaine 15, 20 or 25 mg...
December 13, 2017: Clinical Pharmacokinetics
https://www.readbyqxmd.com/read/29236222/an-indirect-comparison-of-changes-in-the-impact-of-weight-on-quality-of-life-among-subjects-with-type-2-diabetes-treated-with-antihyperglycemic-agents-in-dual-therapy-with-metformin
#17
Shana B Traina, April Slee, Suzy Van Sanden, Joris Diels
INTRODUCTION: It is important to capture the patient experience with a diabetes treatment in clinical trials; however, use of instruments to assess patient-reported outcomes (PROs) in diabetes trials is inconsistent and results may not be reported alongside primary efficacy data. In lieu of head-to-head data, indirect comparisons can be used to compare competing interventions. In this study, we used indirect comparison methods to assess differences in PRO score changes between canagliflozin and other antihyperglycemic agents as add-on to metformin...
December 13, 2017: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/29236221/dpp-4-inhibitor-induced-rheumatoid-arthritis-among-diabetics-a-nested-case-control-study
#18
Niranjan Kathe, Anuj Shah, Qayyim Said, Jacob T Painter
INTRODUCTION: The risk of rheumatoid arthritis (RA) associated with dipeptidyl peptidase-4 inhibitor (DPP-4i) use is unclear. This study assesses the RA risk associated with DPP-4i use among a diabetic cohort initiating second-line therapy. METHODS: This was a nested case-control study, using the adult diabetic population starting second-line antidiabetic therapy from IMS LifeLink Plus® database (2006-2015). Cases were those with two or more RA diagnosis, at least one prescription, and 180 days enrollment prior to the event date (earliest of the two: first RA diagnosis, first RA prescription)...
December 13, 2017: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/29236217/the-association-between-medical-diagnosis-and-caregiver-burden-a-cross-sectional-study-of-recipients-of-informal-support-and-caregivers-from-the-general-population-study-good-aging-in-sk%C3%A3-ne-sweden
#19
Sölve Elmståhl, Beth Dahlrup, Henrik Ekström, Eva Nordell
BACKGROUND: Different kinds of chronic diseases might imply different dimensions of caregiver burden, not previously described among the caregivers to recipients from the general elder population. AIM: The main objective was to examine differences in burden between the 343 caregivers to persons with different diagnoses. METHODS: A group of elderly recipients of informal care (n = 343) from the general population study 'Good Aging in Skåne' (GÅS) Sweden, were divided into five diagnostic groups: dementia (n = 90), heart and lung diseases (n = 48), stroke (n = 62), fractures (n = 66), depression (n = 40) and the group "other", consisting of different diagnoses (n = 37) according to ICD-10...
December 13, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/29236204/the-burden-of-pure-anisometropic-amblyopia-a-cross-sectional-study-on-2800-iranians
#20
Siamak Akbarzadeh, Reihaneh Vahabi, Nooshin Bazzazi, Ghodratollah Roshanaei, Samira Heydarian, Daniel F Fouladi
PURPOSE: To assess the proportion of pure anisometropic amblyopia in a sample Iranian (white) population. METHODS: A total of 2800 consecutive individuals who presented at a referral eye clinic for any reason were examined for the presence of pure anisometropic amblyopia. Anisometropia was reported when a spherical equivalent refraction difference of at least 1.0 D with or without a cylinder refraction difference of at least 1.0 D was present between the two eyes...
December 13, 2017: International Ophthalmology
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