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https://www.readbyqxmd.com/read/28227675/investigating-an-alternative-ring-design-of-transducer-arrays-for-tumor-treating-fields-ttfields
#1
Mario Macedo, Cornelia Wenger, Ricardo Salvador, Sofia R Fernandes, Pedro C Miranda, Mario Macedo, Cornelia Wenger, Ricardo Salvador, Sofia R Fernandes, Pedro C Miranda, Sofia R Fernandes, Pedro C Miranda, Cornelia Wenger, Ricardo Salvador, Mario Macedo
Tumor treating fields (TTFields) is a therapy that inhibits cell proliferation and has been approved by the U.S Food and Drug Administration (FDA) for the treatment of Glioblastoma Multiforme. This anti-mitotic technique works non-invasively and regionally, and is associated with less toxicity and a better quality of life. Currently a device called Optune™ is clinically used which works with two perpendicular and alternating array pairs each consisting of 3×3 transducers. The aim of this study is to investigate a theoretical alternative array design which consists of two rings of 16 transducers and thus permits various field directions...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227673/colorimetric-determinations-of-lithium-levels-in-drop-volumes-of-human-plasma-for-monitoring-patients-with-bipolar-mood-disorder
#2
M Qassem, M Hickey, P A Kyriacou, M Qassem, M Hickey, P A Kyriacou, M Qassem, M Hickey, P A Kyriacou
Lithium preparations are considered the most reliable form of mood stabilizing medication for patients with Bipolar disorder. Nevertheless, lithium is a toxic element and its therapeutic range is extremely narrow, with levels of 0.61.0 mEq considered normal, whereas levels above 1.5 mEq are toxic. Thus unfortunately, many patients reach toxic levels that lead to unnecessary complications. It is believed that personal monitoring of blood lithium levels would benefit patients taking lithium medication. Therefore, our aim is to develop a personal lithium blood level analyzer for patients with bipolar mood disorder, and we report here our initial results of a colorimetric-based method used to test drop-volumes of human plasma that had been spiked with lithium...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226512/hyperthermia-by-electromagnetic-fields-to-enhanced-clinical-results-in-oncology
#3
Gerard C van Rhoon, Maarten M Paulides, Jeannette M L van Holthe, Martine Franckena, Gerard C van Rhoon, Maarten M Paulides, Jeannette M L van Holthe, Martine Franckena, Maarten M Paulides, Martine Franckena, Gerard C van Rhoon, Jeannette M L van Holthe
Confining treatment to the tumor to improve therapeutic outcome and reduce toxicity, is a hot issue in cancer research. Hyperthermia is recognized as a strong sensitizer for radiotherapy and chemotherapy enhancing tumor control without increasing toxicity. Today's electromagnetic hyperthermia systems heat large tissue volumes with limited ability to selectively heat the tumor. Fortunately, tremendous improvements in 3-dimensional electromagnetic & temperature modelling provide an exciting opportunity to design advanced multi-element electromagnetic applicator systems...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226457/forecasting-nanoparticle-toxicity-using-nonlinear-predictive-regressor-learning-systems
#4
N Toschi, S Ciulli, S Diciotti, A Duggento, M Guerrisi, A Magrini, L Campagnolo, A Pietroiusti, N Toschi, S Ciulli, S Diciotti, A Duggento, M Guerrisi, A Magrini, L Campagnolo, A Pietroiusti, M Guerrisi, S Ciulli, L Campagnolo, S Diciotti, A Magrini, A Pietroiusti, A Duggento, N Toschi
Nanoparticle (NP) toxicity is determined by a vast number of topological, sterical, physico-chemical as well as biological properties, rendering a priori evaluation of the effect of NP on biological tissue as arduous as it is necessary and urgent. We aimed at mining the HORIZON 2020 MODENA COST NP cytotoxicity database through nonlinear predictive regressor learning systems in order to assess the power of available NP descriptors and assay characteristics in predicting NP toxicity. Specifically, we assessed the results of cytotoxicity assays performed on 57 NP and trained two different nonlinear regressors (Support Vector Regressors [SVR] with polynomical kernels and Radial Basis Function [RBF] regressors) within a nested-cross validation scheme for parameter optimization to predict toxicity as quantified by EC25, EC50 and slope while using the regressional ReliefF algorithm (RReliefF) for feature selection...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226245/subconjunctival-injectable-dendrimer-dexamethasone-gel-for-the-treatment-of-corneal-inflammation
#5
Uri Soiberman, Siva P Kambhampati, Tony Wu, Manoj K Mishra, Yumin Oh, Rishi Sharma, Jiangxia Wang, Abdul Elah Al Towerki, Samuel Yiu, Walter J Stark, Rangaramanujam M Kannan
Corneal inflammation is often encountered as a key pathological event in many corneal diseases. Current treatments involve topical corticosteroids which require frequent instillations due to rapid tear turnover, causing side-effects such as corneal toxicity and elevated intraocular pressure (IOP). Hence, new interventions that can reduce side effects, dosing frequency, and increase patient compliance can be highly beneficial. In this study, we explore a subconjunctival injectable gel based on G4-PAMAM dendrimer and hyaluronic acid, cross-linked using thiol-ene click chemistry, incorporated with dendrimer dexamethasone (D-Dex) conjugates as a potential strategy for sustained delivery and enhanced bioavailability of corticosteroids...
February 16, 2017: Biomaterials
https://www.readbyqxmd.com/read/28226195/global-transcriptional-response-of-human-liver-cells-to-ethanol-stress-of-different-strength-reveals-hormetic-behavior
#6
Wolfgang Schmidt-Heck, Eva C Wönne, Thomas Hiller, Uwe Menzel, Dirk Koczan, Georg Damm, Daniel Seehofer, Fanny Knöspel, Nora Freyer, Reinhard Guthke, Steven Dooley, Katrin Zeilinger
BACKGROUND: The liver is the major site for alcohol metabolism in the body and therefore, the primary target organ for ethanol-induced toxicity. In this study, we investigated the in vitro response of human liver cells to different ethanol concentrations in a perfused bioartificial liver device that mimics the complex architecture of the natural organ. METHODS: Primary human liver cells were cultured in the bioartificial liver device and treated for 24 hours with medium containing 150 mM (low), 300 mM (medium) or 600 mM (high) ethanol, while a control culture was kept untreated...
February 22, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28226013/suicide-attempts-by-exposure-to-toxic-agents-registered-in-a-toxicological-information-and-assistance-center-in-fortaleza-cear%C3%A3-brazil-2013
#7
Ana Paula Soares Gondim, Rachel Rabay Nogueira, João Gabriel Barbosa Lima, Rayra Aguiar Campos Lima, Polianna Lemos Moura Moreira Albuquerque, Maria do Socorro Batista Veras, Maria Augusta Drago Ferreira
Objective: to describe cases of suicide attempts by exposure to toxic agents registered by the Toxicological Information and Assistance Center in Fortaleza, Ceará, Brazil. Methods: this is a descriptive study using secondary data of the cases registered in 2013. Results: 410 cases were registered; 56.2% of the individuals were female and 79.7% were between 12 and 39 years old; most of them (86.4%) lived in urban areas and 67.2%, in Fortaleza; in 94...
January 2017: Epidemiologia e Servicos de Saude: Revista do Sistema Unico de Saude do Brasil
https://www.readbyqxmd.com/read/28225977/identifying-the-incidence-of-rash-stevens-johnson-syndrome-and-toxic-epidermal-necrolysis-in-patients-taking-lamotrigine-a-systematic-review-of-122-randomized-controlled-trials
#8
Romi Bloom, Kyle T Amber
Lamotrigine is an antiepileptic drug used for the treatment of epilepsy, bipolar disorder and numerous off-label uses. The development of rash significantly affects its use. The most concerning of these adverse reactions is Stevens-Johnson syndrome/toxic epidermal necrolysis. We performed a systematic review of randomized controlled trials using lamotrigine as a monotherapy to quantify the incidence of cutaneous reactions, particularly Stevens-Johnson syndrome/toxic epidermal necrolysis. Of a total of 4,364 papers regarding lamotrigine, 122 studies met our inclusion and exclusion criteria...
January 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28225918/the-aplication-of-cyanoacrilate-surgical-glue-on-skin-suture-in-rats
#9
João Ilgenfritz, Ricardo Dutra Aydos, Iandara Schettert Silva, Rondon Tosta Ramalho, João Ilgenfritz, Gerson Gattats Orro de Campos, Ricardo Kenithi Nakamura, Danilo M Zanello Guerisoli, Wilson de Barros Cantero
Purpose: To compare the use of a new cyanoacrylate-based surgical glue and suture with sepa-rate points in skin wounds closure. Methods: Thirty-six rats were subjected to a 4cm dorsal longitudinal incision. Twelve were sub-jected to simple suture with polyamide 6-0, 12 rats underwent wall synthesis using Dermabond(r) and 12 was performed cutaneous synthesis with N-2-Butyl-Cyanoacrylate. Twelve of each group was euthanized on the seventh postoperative day, their blood was taken to biochemical tests and a layer of skin and subcutaneous tissue surrounding the surgical scar was randomly divided in two segments, to the submission of tension tests and to histological study...
January 2017: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/28225913/ultrasound-as-a-safe-and-reliable-guidance-for-subarachnoid-puncture-in-rabbits
#10
Ivan Dias Fernandes Pereira, Roberto Bezerra Vital, Ronaldo Silva, Felipe Gilberto Valerini, Vania Maria de Vasconcelos Machado, Mariangela Esrher Marques, Helio Miot, Lais Helena Navarro, Eliana Marisa Ganem
Purpose: To evaluate a model for studying the toxicity in nervous tissue and meninges using ultrasound to guide needle insertion into the subarachnoid space of rabbits, with the objective of avoiding injuries triggered by the puncture and by intraneural injection of solutions. Methods: Forty-five adult female rabbits were divided into 3 groups (G): G1 underwent subarachnoid puncture, G2 underwent subarachnoid injection of saline solution and G3 underwent subarachnoid injection of 0...
January 2017: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/28225650/nicaraven-a-potential-radioprotective-agent-has-very-limited-effects-on-the-survival-of-cancer-cells-and-the-growth-of-established-tumors
#11
Chen Yan, Lan Luo, Yoshishige Urata, Shinji Goto, Chang-Ying Guo, Tao-Sheng Li
Radiotherapy is one of the major treatment modalities for the management of various cancers, however, it is limited by the severe side effects and complications experienced by some patients. Nicaraven, a chemically synthesized hydroxyl radical-specific scavenger, has been shown to protect normal tissues from radiation-induced injury. We investigated the role of nicaraven in cancer cells and tumor growth. While nicaraven did not significantly change the colony-forming abilities and DNA damage levels in several cancer cell lines after irradiation, it significantly protected mouse bone marrow-derived hematopoietic stem cells from radiation injury...
February 22, 2017: Radiation Research
https://www.readbyqxmd.com/read/28225579/intravoxel-incoherent-motion-mri-assessment-of-chemoradiation-induced-pelvic-bone-marrow-changes-in-cervical-cancer-and-correlation-with-hematological-toxicity
#12
Elaine Yuen Phin Lee, Jose Angelo Udal Perucho, Vince Vardhanabhuti, Jian He, Steven Wai Kwan Siu, Siew Fei Ngu, Nina A Mayr, William T C Yuh, Queenie Chan, Pek-Lan Khong
PURPOSE: To investigate bone marrow changes after chemoradiation (CRT) using intravoxel incoherent motion magnetic resonance imaging (IVIM-MRI) and correlate imaging changes with hematological toxicity (HT) in patients with locally advanced cervical cancer. MATERIALS AND METHODS: Thirty-nine patients with newly diagnosed cervical cancer were prospectively recruited for two sequential 3.0T IVIM-MRI studies: before treatment (MRI-1) and 3-4 weeks after standardized CRT (MRI-2)...
February 22, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28225501/the-effect-of-induction-chemotherapy-in-patients-with-locally-advanced-nonsmall-cell-lung-cancer-who-received-chemoradiotherapy-a-systematic-review-and-meta-analysis
#13
Hui Luo, Xinshuang Yu, Ning Liang, Jian Xie, Guodong Deng, Qiqi Liu, Jingxin Zhang, Jiandong Zhang, Hong Ge
BACKGROUND: The efficacy and toxicity of induction chemotherapy followed by concurrent chemoradiotherapy (CCRT) in patients with locally advanced nonsmall cell lung cancer (NSCLC) is unclear, we performed a systematic review and meta-analysis of published papers to quantitatively evaluate the potential benefit of induction chemotherapy. METHODS: Eligible studies of induction chemotherapy and chemoradiotherapy were retrieved through extensive searches of the PubMed, Science Direct, Embase, and Cochrane library databases from 1994 to 2015...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28225490/clinical-characteristics-and-outcome-of-spanish-patients-with-anca-associated-vasculitides-impact-of-the-vasculitis-type-anca-specificity-and-treatment-on-mortality-and-morbidity
#14
Roser Solans-Laqué, Guadalupe Fraile, Monica Rodriguez-Carballeira, Luis Caminal, Maria J Castillo, Ferran Martínez-Valle, Luis Sáez, Juan J Rios, Xavier Solanich, Joaquim Oristrell, Francisco Pasquau, Eva Fonseca, Monica Zamora, Jose L Callejas, Begoña Frutos, Monica Abdilla, Patricia Fanlo, Isabel García-Sánchez, Miguel López-Dupla, Bernardo Sopeña, Almudena Pérez-Iglesias, Josep A Bosch
The aim of this study was to describe the clinical characteristics of ANCA-associated vasculitides (AAV) at presentation, in a wide cohort of Spanish patients, and to analyze the impact of the vasculitis type, ANCA specificity, prognostic factors, and treatments administered at diagnosis, in the outcome.A total of 450 patients diagnosed between January 1990 and January 2014 in 20 Hospitals from Spain were included. Altogether, 40.9% had granulomatosis with polyangiitis (GPA), 37.1% microscopic polyangiitis (MPA), and 22% eosinophilic granulomatosis with polyangiitis (EGPA)...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28225482/a-case-report-of-posterior-reversible-encephalopathy-syndrome-in-a-patient-receiving-gemcitabine-and-cisplatin
#15
Hannah Cherniawsky, Neesha Merchant, Micheal Sawyer, Maria Ho
RATIONALE: Posterior reversible encephalopathy syndrome (PRES) is a subacute syndrome causing characteristic neurologic and radiologic findings. PRES is predominantly caused by malignant hypertension though it has been associated with immunosuppressive treatments such as chemotherapy. PATIENT CONCERNS: We describe a case of a 58 year old female who developed fluctuant level of consciousness, agitation. DIAGNOSIS: MRI findings were in keeping with posterior reversible encephalopathy syndrome following cycle 6 of palliative gemcitabine and cisplatin therapy for metastatic cholangiocarcinoma...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28225458/prognostic-factors-and-outcome-of-patients-with-hematological-malignancies-in-phase-i-trials-the-gustave-roussy-scoring-system
#16
Lina Benajiba, Jean-Marie Michot, Capucine Baldini, Laura Faivre, Andrea Varga, Rastilav Balheda, Anas Gazzah, Ecaterina Ileana, Sophie Postel-Vinay, Christophe Massard, Stéphane de Botton, Jean-Charles Soria, Vincent Ribrag
Despite considerable progress in hematological malignancies (HM) biology during the last decades, translation into clinical benefit remains a major challenge. To improve patient selection and identify patients most likely to benefit from phase I trials, we designed and validated, in an independent cohort, a simple prognostic score. Treatment outcome, toxicity, and survival data from 82 consecutive patients enrolled in 14 phase I trials were reviewed (January 2008-February 2012). We validated these results on a prospectively collected cohort (17 phase I trials, February 2012-May 2014, 88 patients)...
February 20, 2017: Anti-cancer Drugs
https://www.readbyqxmd.com/read/28225445/adjuvant-radiotherapy-versus-wait-and-see-strategy-for-pathologic-t3-or-margin-positive-prostate-cancer-a-meta-analysis
#17
M Parvez Shaikh, Fiori Alite, Meng-Jia Wu, Abhishek A Solanki, Matthew M Harkenrider
OBJECTIVE: To conduct a meta-analysis of the randomized controlled trials (RCTs) comparing adjuvant radiotherapy (ART) to wait-and-see (WS) strategy in pathologic T3 or margin-positive prostate cancer. METHODS: A comprehensive EMBASE, MEDLINE, http://www.clinicaltrails.gov, and Cochrane Library search for RCTs of ART versus WS was done. Results were synthesized for metastasis-free, biochemical progression-free, clinical progression-free, hormone-free, and overall survival as well as gastrointestinal (GI) and genitourinary (GU) toxicities...
February 20, 2017: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28225444/third-line-salvage-chemotherapy-for-recurrent-carcinoma-of-the-cervix-is-associated-with-minimal-response-rate-and-high-toxicity
#18
Dustin B Manders, Siobhan M Kehoe, David S Miller, Jayanthi S Lea, Debra L Richardson
BACKGROUND: Metastatic and recurrent cervical cancer is rarely a curable disease. Systemic chemotherapy is typically recommended for treatment based on clinical trials in the first-line or second-line setting. Rare patients who progress through 2 salvage regimens will have the performance status, medical ability, and desire to continue cytotoxic therapy. For these patients, there are no data to provide effective counseling regarding expected response rates (RRs) and toxicities. We sought to review our experience with this patient population...
February 20, 2017: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28225374/characterizing-the-toxicity-and-dose-effect-profile-of-tramadol-ingestions-in-children
#19
Gina L Stassinos, Lawrence Gonzales, Wendy Klein-Schwartz
OBJECTIVES: Tramadol can cause life-threatening toxicity in overdose; however, data on its toxicity in children are lacking. This study investigates toxicity associated with tramadol ingestions in children. The hypothesis is that children will experience dose-related central nervous system and respiratory depression and seizures. METHODS: A retrospective evaluation of cases from the National Poison Center Data System between January 1, 2000, and December 31, 2013, was performed...
February 21, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/28225264/fatty-acid-comprising-lysine-conjugates-anti-mrsa-agents-that-display-in-vivo-efficacy-by-disrupting-biofilms-with-no-resistance-development
#20
Mohini Mohan Konai, Jayanta Haldar
Methicillin-resistant Staphylococcus aureus (MRSA) have developed resistance to antibiotics of last resort such as vancomycin, linezolid and daptomycin. Additionally, their biofilm forming capability has set an alarming situation in the treatment of bacterial infections. Herein we report the potency of fatty acid comprising lysine conjugates as novel anti-MRSA agents, which were not only capable of killing growing planktonic MRSA at low concentration (MIC = 3.1-6.3 µg/mL), but also displayed potent activity against non-dividing stationary phase cells...
February 22, 2017: Bioconjugate Chemistry
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