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https://www.readbyqxmd.com/read/29145577/photodynamic-therapy-leads-to-time-dependent-regression-of-pathologic-corneal-lymph-angiogenesis-and-promotes-high-risk-corneal-allograft-survival
#1
Yanhong Hou, Viet Nhat Hung Le, Thomas Clahsen, Ann-Charlott Schneider, Felix Bock, Claus Cursiefen
Purpose: Pathologic corneal (lymph) angiogenesis is a known risk factor for immune-mediated allograft rejections after corneal transplantation. However, there is no established treatment to regress pre-existing pathological corneal blood and lymphatic vessels. This study assessed the possibility to regress both vessel types by photodynamic therapy (PDT) after intravenous (i.v.) verteporfin injection, the influence of timing of PDT after verteporfin injection, and the effect on graft survival in high-risk keratoplasty...
November 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29142592/advances-in-age-related-macular-degeneration-understanding-and-therapy
#2
Joan W Miller, Saghar Bagheri, Demetrios G Vavvas
While the development of anti-vascular endothelial growth factor (anti-VEGF) as a therapy for neovascular age-related macular degeneration (AMD) was a great success, the pathologic processes underlying dry AMD that eventually leads to photoreceptor dysfunction, death, and vision loss remain elusive to date, with a lack of effective therapies and increasing prevalence of the disease. There is an overwhelming need to improve the classification system of AMD, to increase our understanding of cell death mechanisms involved in both neovascular and non-neovascular AMD, and to develop better biomarkers and clinical endpoints to eventually be able to identify better therapeutic targets-especially early in the disease process...
2017: US Ophthalmic Review
https://www.readbyqxmd.com/read/29138977/-reasons-for-delayed-and-discontinued-therapy-in-age-related-macular-degeneration
#3
M W M Wintergerst, J Bouws, J Loss, B Heimes, D Pauleikhoff, F G Holz, R P Finger
BACKGROUND: Critical prerequisites for successful therapy of neovascular age-related macular degeneration (nvAMD) are an early initiation and continuous monitoring; however, delays in starting therapy and non-medically indicated discontinuation of therapy are frequent, which limits therapy efficacy and, thus, visual outcomes. OBJECTIVE: To identify the reasons for delay in therapy and non-medically indicated termination of therapy. MATERIAL AND METHODS: Patients who had started a new therapy (starters) and those who independently terminated therapy (dropouts) were interviewed by telephone with a specific, standardized questionnaire...
November 14, 2017: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/29138543/location-of-submacular-hemorrhage-as-a-predictor-of-visual-outcome-after-intravitreal-ranibizumab-for-age-related-macular-degeneration
#4
Dimitrios Karagiannis, Irini Chatziralli, Konstantinos Kaprinis, Ilias Georgalas, Efstratios Parikakis, Panagiotis Mitropoulos
Purpose: To evaluate the anatomical and functional outcomes in patients with submacular hemorrhage (SMH) due to age-related macular degeneration (AMD) treated with ranibizumab, and to evaluate the potential role of the SMH location in the final outcome after treatment. Methods: Participants in this study were 12 treatment-naïve patients with SMH due to neovascular AMD who were treated with intravitreal ranibizumab and had at least 12 months' follow-up. All patients underwent best-corrected visual acuity measurement and optical coherence tomography at baseline and at every visit posttreatment, while fluorescein angiography was done at baseline and at the discretion of the physician thereafter...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29137420/anti-angiogenic-and-anti-tumor-effects-of-metronomic-use-of-novel-liposomal-zoledronic-acid-depletes-tumor-associated-macrophages-in-triple-negative-breast-cancer
#5
Xin-Jun Cai, Zeng Wang, Jia-Wei Cao, Jian-Jun Ni, Ying-Ying Xu, Jun Yao, Hong Xu, Fang Liu, Gao-Yi Yang
Zoledronic acid (ZOL) has been used as an adjuvant therapy for breast cancer. It is suggested that ZOL might be associated with inhibition of macrophages, which in turn reduces tumor growth, metastasis and tumor angiogenesis. Moreover, metronomic therapy can inhibit tumor angiogenesis and tumor immune cells. Previously we developed ZOL based cationic liposomes that allowed a higher intratumor delivery of drug compared with free ZOL in vivo. Therefore, in this study, Asn-Gly-Arg (NGR) and PEG2000 were used as ligands to modify the surface of liposomes (NGR-PEG-LP-ZOL) in metronomic therapy to clear the tumor-associated macrophages (TAMs) and inhibit the formation of tumor angiogenesis, achieving the purpose of anti-tumor growth...
October 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/29137139/deduction-of-novel-genes-potentially-involved-in-osteoblasts-of-rheumatoid-arthritis-using-next-generation-sequencing-and-bioinformatic-approaches
#6
Yi-Jen Chen, Wei-An Chang, Ya-Ling Hsu, Chia-Hsin Chen, Po-Lin Kuo
The role of osteoblasts in peri-articular bone loss and bone erosion in rheumatoid arthritis (RA) has gained much attention, and microRNAs are hypothesized to play critical roles in the regulation of osteoblast function in RA. The aim of this study is to explore novel microRNAs differentially expressed in RA osteoblasts and to identify genes potentially involved in the dysregulated bone homeostasis in RA. RNAs were extracted from cultured normal and RA osteoblasts for sequencing. Using the next generation sequencing and bioinformatics approaches, we identified 35 differentially expressed microRNAs and 13 differentially expressed genes with potential microRNA-mRNA interactions in RA osteoblasts...
November 11, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29135888/exit-strategy-in-a-treat-and-extend-regimen-for-exudative-age-related-macular-degeneration
#7
Petra Arendt, Siqing Yu, Marion R Munk, Andreas Ebneter, Sebastian Wolf, Martin S Zinkernagel
PURPOSE: To evaluate the outcome of an exit strategy in a treat-and-extend regimen for neovascular age-related macular degeneration. METHODS: Five hundred and ninety-eight eyes of 488 patients with neovascular age-related macular degeneration receiving intravitreal anti-vascular endothelial growth factor injections according to a treat-and-extend regimen were included in this retrospective study. A treat-and-extend regimen with either interval extension by 2 weeks or shortening by 1 week was used...
November 9, 2017: Retina
https://www.readbyqxmd.com/read/29135803/vascular-abnormalities-in-diabetic-retinopathy-assessed-with-swept-source-optical-coherence-tomography-angiography-widefield-imaging
#8
Karen B Schaal, Marion R Munk, Iris Wyssmueller, Lieselotte E Berger, Martin S Zinkernagel, Sebastian Wolf
PURPOSE: To detect vascular abnormalities in diabetic retinopathy using swept-source optical coherence tomography angiography (SS-OCTA) widefield images, and to compare the findings with color fundus photographs (CFPs) using Early Treatment Diabetic Retinopathy Study severity grading. METHODS: 3 mm × 3 mm and 12 mm × 12 mm scans were acquired to cover 70° to 80° of the posterior pole using a 100-kHz SS-OCTA instrument. Two masked graders assessed the presence of vascular abnormalities on SS-OCTA and the Early Treatment Diabetic Retinopathy Study level on CFP...
November 10, 2017: Retina
https://www.readbyqxmd.com/read/29135605/novel-method-to-detect-corneal-lymphatic-vessels-in-vivo-by-intrastromal-injection-of-fluorescein
#9
Viet Nhat Hung Le, Yanhong Hou, Jens Horstmann, Felix Bock, Claus Cursiefen
PURPOSE: Corneal lymphatic vessels are clinically invisible because of their thin walls and clear lymph fluid. There is no easy and established method for in vivo imaging of corneal lymphatic vessels so far. In this study, we present a novel approach to visualize corneal lymphatic vessels in vivo by injecting intrastromal fluorescein sodium. METHODS: Six- to eight-week-old female BALB/c mice were used in the mouse model of suture-induced corneal neovascularization...
November 9, 2017: Cornea
https://www.readbyqxmd.com/read/29135355/changes-in-ocular-hemodynamics-after-carotid-artery-angioplasty-and-stenting-caas-in-patients-with-different-severity-of-ocular-ischemic-syndrome
#10
Feiyan Ma, Jing Su, Qingli Shang, Jingxue Ma, Tongdi Zhang, Xin Wang, Honglei Ma, Jianghua Yu
PURPOSE: To evaluate the effects of carotid artery angioplasty and stenting (CAAS) on patients who were diagnosed with ocular ischemic syndrome (OIS). METHODS: Sixty-four eyes of 64 OIS patients with ipsilateral internal carotid artery stenosis ≥70% were included in the study. The study eyes were divided into two groups according to the presence of iris neovascularization: NVI-absent group and NVI-present group, with 32 eyes, respectively. All patients received ocular treatment modality according to the presence of non-perfusion area (pan-retinal photocoagulation) and intraocular pressure (medical treatment included timolol maleate eye drops combined with brinzolamide eye drop; trabeculectomy and cyclophotocoagulation)...
November 14, 2017: Current Eye Research
https://www.readbyqxmd.com/read/29133977/5-aza-2-deoxycytidine-protects-against-emphysema-in-mice-via-suppressing-p16-ink4a-expression-in-lung-tissue
#11
Zhi-Hui He, Yan Chen, Ping Chen, Sheng-Dong He, Hui-Hui Zeng, Ji-Ru Ye, Da Liu, Jun Cao
Background: There is a growing realization that COPD, or at least emphysema, involves several processes presenting in aging and cellular senescence. Endothelial progenitor cells (EPCs) contribute to neovascularization and play an important role in the development of COPD. The gene for p16(Ink4a) is a major dominant senescence one. The aim of the present study was to observe changes in lung function, histomorphology of lung tissue, and expression of p16(Ink4a) in lung tissue and bone marrow-derived EPCs in emphysematous mice induced by cigarette-smoke extract (CSE), and further to search for a potential candidate agent protecting against emphysema induced by CSE...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29133644/stenotrophomonas-maltophilia-an-emerging-entity-for-cluster-endophthalmitis
#12
Sarita Beri, Anurag Shandil, Rajiv Garg
PURPOSE: This was a study of acute cluster endophthalmitis along with clinical features, culture results, and visual outcomes of 10 eyes of 10 patients after intravitreal injection of Avastin (bevacizumab) in one sitting from a single vial. METHODS: Retrospective review of intravitreal injection of 1.25 mg/0.05 ml bevacizumab that was given to 10 eyes of 10 patients on the same day from a freshly opened vial. All patients manifested with endophthalmitis the next day...
November 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29133637/the-inhibitory-effect-of-different-concentrations-of-kh902-eye-drops-on-corneal-neovascularization-induced-by-alkali-burn
#13
Yan Wu, Chunyan Xue, Yan Lu, Zhenping Huang
PURPOSE: The aim of this study was to evaluate the inhibitory effect of different concentrations of KH902 eye drops on rabbit corneal neovascularization (CNV) induced by alkali burn. METHODS: Forty-eight adult rabbits were randomized into four groups after alkali burning: Group A (2.5 mg/ml), Group B (5 mg/ml), and Group C (10 mg/ml) by different concentrations of KH902 eye drops and Group D by saline solution as control with three times a day for 2 weeks. At days 7, 14, and 28, the anterior segment photographs, confocal microscopy, and histopathology were performed to evaluate corneal opacity, neovascularization, inflammatory cell density, vessel size, and edema...
November 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29133037/the-novel-4-phenyl-2-phenoxyacetamide-thiazoles-modulates-the-tumor-hypoxia-leading-to-the-crackdown-of-neoangiogenesis-and-evoking-the-cell-death
#14
Yasser Hussein Eissa Mohammed, Vikas H Malojirao, Prabhu Thirusangu, Mohammed Al-Ghorbani, B T Prabhakar, Shaukath Ara Khanum
Tumor microenvironment is a complex multistep event which involves several hallmarks that transform the normal cell into cancerous cell. Designing the novel antagonistic molecule to reverse the tumor microenvironment with specific target is essential in modern biological studies. The novel 4-phenyl-2-phenoxyacetamide thiazole analogues 8a-ab were synthesized in multistep process, then screened and assessed for cytotoxic and anti-proliferative effects in vitro against multiple cancer cells of different origin such as MCF-7, A549, EAC and DLA cells which revealed that compound 8f with fluoro and methyl substitute has potential cytotoxic efficacy with an average IC50 value of ˜ 13 μM...
November 4, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29132470/-effects-of-bone-marrow-mesenchymal-stem-cell-transplantation-on-retinal-neovascularization-in-neonatal-rats-with-oxygen-induced-retinopathy
#15
Qing-Jie Mu, Yue-Hua Zhao, Dan-Dan Cheng, Hai-Yu Wang, Lan-Fen Chen, Yan-Song Zhao, Xiao-Li Wang
OBJECTIVE: To explore the effects of rat bone mesenchymal stem cell (BMSC) transplantation on retinal neovascularization, and to observe the changes of hypoxia-inducible factor-1 alpha (HIF-1α) and vascular endothelial growth factors (VEGF) in rats with oxygen-induced retinopathy (OIR). METHODS: Seventy-two seven-day-old Sprague-Dawley rats were randomly divided into three groups: normal control (CON), model (OIR) and BMSC transplantation. In the BMSC transplantation group, BMSCs were transplanted 5 days after oxygen conditioning...
November 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/29131696/risk-factors-for-discontinuation-of-treatment-for-neovascular-age-related-macular-degeneration
#16
Inger Westborg, Aldana Rosso
PURPOSE: To investigate risk factors for treatment discontinuation for neovascular age-related macular degeneration (nAMD). METHODS: Data from the Swedish Macula Register and the Skåne Healthcare Register are reported on the treatment received by 932 nAMD patients diagnosed 2013-2015. Treatment discontinuation is defined as having a termination visit or lacking a control or treatment visit during the period of 10-14 months after the diagnostic visit. The risk of treatment discontinuation during the first year is estimated using a Poisson model and a classification tree...
November 13, 2017: Ophthalmic Epidemiology
https://www.readbyqxmd.com/read/29131497/development-of-endothelial-cell-networks-in-3d-tissues-by-combination-of-melt-electrospinning-writing-with-cell-accumulation-technology
#17
Sarah Bertlein, Daichi Hikimoto, Gernot Hochleitner, Julia Hümmer, Tomasz Jungst, Michiya Matsusaki, Mitsuru Akashi, Jürgen Groll
A remaining challenge in tissue engineering approaches is the in vitro vascularization of engineered constructs or tissues. Current approaches in engineered vascularized constructs are often limited in the control of initial vascular network geometry, which is crucial to ensure full functionality of these constructs with regard to cell survival, metabolic activity, and potential differentiation ability. Herein, the combination of 3D-printed poly-ε-caprolactone scaffolds via melt electrospinning writing with the cell-accumulation technique to enable the formation and control of capillary-like network structures is reported...
November 13, 2017: Small
https://www.readbyqxmd.com/read/29131493/gaming-to-improve-vision-21-st-century-self-monitoring-for-patients-with-age-related-macular-degeneration
#18
Hessom Razavi, Elizabeth Baglin, Pyrawy Sharangan, Emily Caruso, Nicole Tindill, Susan Griffin, Robyn Guymer
IMPORTANCE: Improved vision self-monitoring tools are required for people at risk of neovascular complications from age related macular degeneration (AMD). BACKGROUND: To report the self-monitoring habits of participants with intermediate AMD using the Amsler grid chart, and the use of personal electronic devices and gameplay in this over 50 year old cohort. DESIGN: Single-centre descriptive study carried out at the Centre for Eye Research (CERA), Melbourne, Australia...
November 13, 2017: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/29130626/age-related-macular-degeneration-using-morphological-predictors-to-modify-current-treatment-protocols
#19
REVIEW
Mohammed Ashraf, Ahmed Souka, Ron A Adelman
To assess predictors of treatment response in neovascular age-related macular degeneration (AMD) in an attempt to develop a patient-centric treatment algorithm. We conducted a systematic search using PubMed, EMBASE and Web of Science for prognostic indicators/predictive factors with the key words: 'age related macular degeneration', 'neovascular AMD', 'choroidal neovascular membrane (CNV)', 'anti-vascular endothelial growth factor (anti-VEGF)', 'aflibercept', 'ranibizumab', 'bevacizumab', 'randomized clinical trials', 'post-hoc', 'prognostic', 'predictive', 'response' 'injection frequency, 'treat and extend (TAE), 'pro re nata (PRN)', 'bi-monthly' and 'quarterly'...
November 11, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29129600/mabp1-targeting-interleukin-1alpha-for-moderate-to-severe-hidradenitis-suppurativa-not-eligible-for-adalimumab-a-randomized-study
#20
Theodora Kanni, Maria Argyropoulou, Themistoklis Spyridopoulos, Aikaterini Pistiki, Michael Stecher, Charles A Dinarello, John Simard, Evangelos J Giamarellos-Bourboulis
BACKGROUND: Patients with moderate to severe hidradenitis suppurativa (HS) failing adalimumab therapy, or those ineligible to receive it, remain a population with an unmet need. METHODS: 20 patients not eligible for adalimumab were randomized to receive 12 weeks blind treatment with placebo or MABp1, a true human antibody targeting interleukin (IL)-1alpha. HS clinical response score at week 12 was the primary endpoint. RESULTS: The primary endpoint was met in 10% and 60% of placebo- and MABp1-treated patients respectively (odds ratio 13...
November 9, 2017: Journal of Investigative Dermatology
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