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https://www.readbyqxmd.com/read/29332249/correlation-of-flow-density-as-measured-using-optical-coherence-tomography-angiography-with-structural-and-functional-parameters-in-glaucoma-patients
#1
Maged Alnawaiseh, Larissa Lahme, Viktoria Müller, André Rosentreter, Nicole Eter
PURPOSE: To evaluate the correlation between flow density, as measured by optical coherence tomography angiography (OCTA), and structural and functional parameters in patients with open-angle glaucoma. METHODS: Thirty-four eyes of 34 patients with open-angle glaucoma and 35 eyes of 35 healthy subjects were prospectively included in this study. OCTA was performed using RTVue XR Avanti with AngioVue. The macula was imaged with a 3 × 3 mm scan and the optic nerve head (ONH) with a 4...
January 13, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29332122/quantitative-study-of-the-macular-microvasculature-in-human-donor-eyes
#2
Paula K Yu, Zaid Mammo, Chandrakumar Balaratnasingam, Dao-Yi Yu
Purpose: To precisely quantify the macular microvasculature density using microperfusion and labeling techniques in human donor eyes. Such information may be useful in understanding the role of the macular microvasculature in coping with the metabolic requirements of the neurons in this densely packed region, and provide a reference point for clinical studies using recently developed optical imaging techniques. Methods: The macular microvasculature was perfusion-labeled in 18 human donor eyes and optical stacks collected from regions superior, temporal, inferior, and nasal to the foveola using confocal microscopy...
January 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29332050/supplemental-retinal-carotenoids-enhance-memory-in-healthy-individuals-with-low-levels-of-macular-pigment-in-a-randomized-double-blind-placebo-controlled-clinical-trial
#3
Rebecca Power, Robert F Coen, Stephen Beatty, Riona Mulcahy, Rachel Moran, Jim Stack, Alan N Howard, John M Nolan
BACKGROUND: There is a biologically plausible rationale whereby the dietary carotenoids lutein (L), zeaxanthin (Z), and meso-zeaxanthin (MZ), which are collectively referred to as macular pigment (MP) in the central retina (macula), support the maintenance of cognition via their antioxidant and anti-inflammatory properties. OBJECTIVE: To investigate the impact of supplemental L, Z, and MZ on memory, executive function, and verbal fluency among healthy individuals with low MP levels...
2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29329138/relationship-of-macular-thickness-and-function-to-optical-microangiography-measurements-in-glaucoma
#4
Harsha L Rao, Mohammed Riyazuddin, Srilakshmi Dasari, Narendra K Puttaiah, Zia S Pradhan, Robert N Weinreb, Kaweh Mansouri, Carroll A B Webers
PURPOSE: To evaluate the relationship between macular optical microangiography (OMAG), ganglion cell-inner plexiform layer (GCIPL) thickness and visual sensitivity measurements of different macular sectors in primary open angle glaucoma (POAG). METHODS: In a cross-sectional study, 39 eyes of 26 POAG patients underwent OCT imaging and 10-2 visual field examination of the macula in the same session. Linear regression models were used to evaluate the relationships between OMAG, GCIPL thickness and visual sensitivity measurements in different macular sectors...
January 11, 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29329137/macular-and-multifocal-perg-and-fd-oct-in-pre-perimetric-and-hemifield-loss-glaucoma
#5
André Carvalho Kreuz, Carlos Gustavo de Moraes, Marcelo Hatanaka, Maria Kiyoko Oyamada, Mario L R Monteiro
PURPOSE: To evaluate the ability of macular and multifocal (mf) pattern electroretinogram (PERG) to differentiate pre-perimetric glaucoma (PG) and glaucoma with hemifield loss (GHL) from controls, to compare the discrimination ability of PERG and fourier-domain optical coherence tomography (fdOCT), and to assess the relationship between measurements. METHODS: Standard automated perimetry, [1] steady-state and transient PERG and mfPERG measurements were obtained from PG (n=14, 24 eyes), GHL (n=5, 7 eyes) and controls (n=19, 22 eyes)...
January 11, 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29327737/uphill-downhill-nystagmus
#6
M Gufoni
Differential diagnosis between peripheral and central spontaneous nystagmus can be difficult to classify (as peripheral or central) even on the basis of criteria recommended in the recent literature. The aim of this paper is to use the combination of spontaneous nystagmus and ocular tilt reaction to determine the site of origin of the disease that causes nystagmus. We propose to classify the nystagmus in: 1) "Uphill" nystagmus in which the nystagmus takes on an inclined plane and the direction of the fast phase is towards the hypertropic eye (this type of nystagmus is likely peripheral); 2) "Downhill" nystagmus when the nystagmus beats toward the hypotropic eye (this type of nystagmus is likely central); 3) "Flat" nystagmus when the plane on which nystagmus beats is perfectly horizontal: in this case, we cannot say anything about the site of lesion (it was only detected in 15% of cases)...
December 2017: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/29326854/macular-buckling-surgery-for-retinal-detachment-associated-with-macular-hole-in-high-myopia-eye
#7
Kenan Sönmez, Ali Keleş
A 68-year-old woman presented to our clinic with a 1-month history of central scotoma and visual loss in her right eye. The best corrected visual acuity (BCVA) was hand motion in her right eye. Fundus examination showed myopic chorioretinal degeneration in association with posterior staphyloma and the retina was slightly elevated throughout the macula. Optical coherence tomography (OCT) revealed retinal detachment involving the posterior pole with a macular hole and staphyloma. The patient underwent pars plana vitrectomy, internal limiting membrane peeling, macular buckling, and perfluoropropane gas tamponade...
December 2017: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/29326849/spectral-domain-optical-coherence-tomography-findings-in-carotid-artery-disease
#8
Akın Çakır, Eyüp Düzgün, Serkan Demir, Yavuz Çakır, Melih Hamdi Ünal
Objectives: To evaluate the effect of carotid artery disease on retinal morphology by means of spectral domain optical coherence tomography (SD-OCT). Materials and Methods: We examined 23 eyes with internal carotid artery (ICA) stenosis and 24 age- and gender-matched healthy eyes as a control group in this prospective, case-control study. Compherensive ophthalmic examination and SD-OCT scan were performed to all the patients. The average RNFL and macular thicknesses (MT) in the nine macular ETDRS areas were the major OCT measurements for our study...
December 2017: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/29315706/a-basis-for-customising-perimetric-locations-within-the-macula-in-glaucoma
#9
Muhammed S Alluwimi, William H Swanson, Victor E Malinovsky, Brett J King
PURPOSE: It has been recognised that the 24-2 grid used for perimetry may poorly sample the macula, which has been recently identified as a critical region for diagnosing and managing patients with glaucoma. We compared data derived from patients and controls to investigate the efficacy of a basis for customising perimetric locations within the macula, guided by en face images of retinal nerve fibre layer (RNFL) bundles. METHODS: We used SD-OCT en face montages (www...
January 8, 2018: Ophthalmic & Physiological Optics: the Journal of the British College of Ophthalmic Opticians (Optometrists)
https://www.readbyqxmd.com/read/29315126/recurrent-opening-and-closure-of-macular-hole-after-pars-plana-vitrectomy-for-rhegmatogenous-retinal-detachment
#10
Ece Ozdemir, Sengul Ozdek
PURPOSE: To report a case of full-thickness macular hole formation and closure twice after pars plana vitrectomy for macula-off rhegmatogenous retinal detachment. METHODS: Case report. RESULTS: A 45-year-old woman with a macula-off rhegmatogenous retinal detachment underwent uncomplicated pars plana vitrectomy with silicone oil tamponade, which was removed 3 months postoperatively. A full-thickness macular hole developed spontaneously 18 months after silicone oil removal, concurrently with the formation of epiretinal membrane and perifoveal cystoid changes...
January 5, 2018: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/29314673/purpuriforme-maculae-und-plaques-bei-einem-patienten-mit-myasthenia-gravis
#11
Marco A Chessa, Carlotta Gurioli, Emi Dika, Cosimo Misciali, Michela Crisci, Annalisa Patrizi
No abstract text is available yet for this article.
January 2018: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/29313132/-rpe-morphometry-in-geographic-atrophy-due-to-amd
#12
A Wagner, A Mohi, M Ranjbar, S Grisanti, M Rudolf
BACKGROUND: The geographic atrophy (GA) junctional zone includes changes in retinal pigment epithelium (RPE) and Bruch's membrane complex that are still difficult to interpret even with clinical high-resolution imaging technologies. We measured and evaluated degenerative RPE cell changes in histological sections of GA eyes. METHODS: In this study seven GA eyes were evaluated by light microscopy. In three eye sections, zones of typical RPE alterations were graded (0 = normal; 1 = irregular cells but intact layer; 2 = rounded, enlarged, and/or heaped cells; 3 = migrating cells in retina; 4 = RPE absent)...
January 8, 2018: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/29310964/early-patterns-of-macular-degeneration-in-abca4-associated-retinopathy
#13
Kamron N Khan, Melissa Kasilian, Omar A R Mahroo, Preena Tanna, Angelos Kalitzeos, Anthony G Robson, Kazushige Tsunoda, Takeshi Iwata, Anthony T Moore, Kaoru Fujinami, Michel Michaelides
PURPOSE: To describe the earliest features of ABCA4-associated retinopathy. DESIGN: Case series. PARTICIPANTS: Children with a clinical and molecular diagnosis of ABCA4-associated retinopathy without evidence of macular atrophy. METHODS: The retinal phenotype was characterized by color fundus photography, OCT, fundus autofluorescence (FAF) imaging, electroretinography, and in 2 patients, adaptive optics scanning laser ophthalmoscopy (AOSLO)...
January 5, 2018: Ophthalmology
https://www.readbyqxmd.com/read/29304270/a-new-oct-finding-in-purtscher-like-retinopathy
#14
Sevil Ari Yaylali, Nedim Bromand, Guler Kilic
The authors report a new spectral-domain optical coherence tomography (SD-OCT) appearance observed in two patients with Purtscher-like retinopathy. In this prospective case series of three eyes of two patients with Purtscher-like retinopathy, the patients were assessed with biomicroscopy, fluorescein angiography (FA), and SD-OCT. The last examinations of the patients were performed at 3 months and 12 months, respectively. Both patients presented with decreased visual acuity. Fundus examination revealed a whitish-appearing parafoveal retina and scattered cotton-wool spots in the posterior retina...
January 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/29303870/the-association-between-macula-and-onh-optical-coherence-tomography-angiography-oct-a-vessel-densities-in-glaucoma-glaucoma-suspect-and-healthy-eyes
#15
Patricia Isabel C Manalastas, Linda M Zangwill, Fabio B Daga, Mark A Christopher, Luke J Saunders, Takuhei Shoji, Tadamichi Akagi, Rafaella C Penteado, Adeleh Yarmohammadi, Min Hee Suh, Felipe A Medeiros, Robert N Weinreb
PURPOSE: To evaluate strength of associations between Optical Coherence Tomography-Angiography (OCT-A) vessel density (VD) measurements in the macula and peripapillary region of the optic nerve head (ONH) with standard structural OCT thickness measures. METHODS: This cross-sectional study included 333 eyes of 219 primary open angle glaucoma patients, 41 glaucoma suspects, and 73 healthy participants from the Diagnostics Innovations in Glaucoma Study (DIGS) with good quality OCT-A images...
January 4, 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29300765/optical-coherence-tomography-for-glaucoma-diagnosis-an-evidence-based-meta-analysis
#16
Vinay Kansal, James J Armstrong, Robert Pintwala, Cindy Hutnik
PURPOSE: Early detection, monitoring and understanding of changes in the retina are central to the diagnosis of glaucomatous optic neuropathy, and vital to reduce visual loss from this progressive condition. The main objective of this investigation was to compare glaucoma diagnostic accuracy of commercially available optical coherence tomography (OCT) devices (Zeiss Stratus, Zeiss Cirrus, Heidelberg Spectralis and Optovue RTVue, and Topcon 3D-OCT). PATIENTS: 16,104 glaucomatous and 11,543 normal eyes reported in 150 studies...
2018: PloS One
https://www.readbyqxmd.com/read/29299741/functional-and-structural-outcomes-of-ilm-peeling-in-uncomplicated-macula-off-rrd-using-microperimetry-en-face-oct
#17
Mohamed Gaber Ahmed Mohamed Eissa, Mohamad Amr Salah Eddin Abdelhakim, Tamer Ahmed Macky, Mohamed Mahmoud Khafagy, Hassan Aly Mortada
PURPOSE: To investigate functional and structural outcomes of internal limiting membrane (ILM) peeling during primary vitrectomy for uncomplicated macula-off rhegmatogenous retinal detachment (RRD). METHODS: In this prospective interventional randomized comparative study, 43 eyes (43 patients) were randomly divided into group A (20), and group B (23), with and without ILM peeling respectively. Patients were evaluated clinically, and by spectral-domain optical coherence tomography (SD-OCT) and microperimetry (MP) following silicone oil removal...
January 3, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29283145/optical-coherence-tomography-angiography-features-of-bilateral-retinopathy-associated-with-chikungunya-fever
#18
Aniruddha Agarwal, Tripti Choudhary, Vishali Gupta
A 66-year-old male patient presented with decreased vision in both eyes following episode of Chikungunya fever. Examination revealed bilateral retinal lesions with stippled pigmentary changes at the level of the choriocapillaris, involving the macula in the left eye. The retinopathy consisted of outer retinal disruption and retinochoroidal flow abnormalities detected using with additional imaging, including spectral-domain optical coherence tomography (OCT), autofluorescence, and OCT angiography (OCTA). The index case report describes unique OCTA findings in both eyes of an elderly male secondary to Chikungunya fever...
January 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29283118/optical-coherence-tomography-a-guide-to-interpretation-of-common-macular-diseases
#19
REVIEW
Muna Bhende, Sharan Shetty, Mohana Kuppuswamy Parthasarathy, S Ramya
Optical coherence tomography is a quick, non invasive and reproducible imaging tool for macular lesions and has become an essential part of retina practice. This review address the common protocols for imaging the macula, basics of image interpretation, features of common macular disorders with clues to differentiate mimickers and an introduction to choroidal imaging . It includes case examples and also a practical algorithm for interpretation.
January 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29282883/measuring-polarization-changes-in-the-human-outer-retina-with-polarization-sensitive-optical-coherence-tomography
#20
Barry Cense, Donald T Miller, Brett J King, Thomas Theelen, Ann E Elsner
Morphological changes in the outer retina such as drusen are established biomarkers to diagnose age-related macular degeneration. However earlier diagnosis might be possible by taking advantage of more subtle changes that accompany tissues that bear polarization-altering properties. To test this hypothesis, we developed a method based on polarization-sensitive optical coherence tomography with which volumetric data sets of the macula were obtained from 10 young (<25 yr) and 10 older (>54 yr) subjects...
December 28, 2017: Journal of Biophotonics
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