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https://www.readbyqxmd.com/read/29160785/scleral-pits-in-choroideremia-implications-for-retinal-gene-therapy
#1
Abdullah A Al-Qahtani, Shakoor Ba-Ali, Talal Alabduljalil, Aaron S Coyner, Rachel C Patel, Richard G Weleber, Aniz Girach, Søren K Christensen, Michael Larsen, Mark E Pennesi, Paul Yang
PURPOSE: We report a novel finding on spectral domain optical coherence tomography in patients with choroideremia, which we describe as scleral pits (SCPs). METHODS: Cross-sectional observational case series of 36 patients with choroideremia, who underwent ophthalmic examination and multimodal imaging, including optical coherence tomography of the macula. Optical coherence tomography images were reviewed for SCP, which were defined as discrete tracts of hyporeflectivity that traverse the sclera with or without the involvement of Bruch membrane, retinal pigment epithelium, and retina...
November 16, 2017: Retina
https://www.readbyqxmd.com/read/29160781/choroidal-thickness-changes-in-acute-zonal-occult-outer-retinopathy
#2
Hiroki Maehara, Tetsuju Sekiryu, Yukinori Sugano, Ichiro Maruko
PURPOSE: To investigate the longitudinal morphologic choroidal changes in eyes with acute zonal occult outer retinopathy. METHODS: In this retrospective observational case series, we studied 10 patients (11 eyes) with unilateral acute zonal occult outer retinopathy at the first visit who were followed more than 12 months by enhanced depth optical coherence tomography. The retinal and choroidal thicknesses (CTs) were measured at six sites in the macula. RESULTS: The integrity of the ellipsoid zone was lost 1,500 μm and 3,000 μm nasally in all 11 eyes at the first visit...
November 16, 2017: Retina
https://www.readbyqxmd.com/read/29160545/benign-familial-fleck-retina-multimodal-imaging-including-optical-coherence-tomography-angiography
#3
Jose Mauricio Botto de Barros Garcia, David Leonardo Cruvinel Isaac, Tainara Sardeiro, Érika Aquino, Marcos Avila
This report presents multimodal imaging of a 27-year-old woman diagnosed with benign familial fleck retina (OMIM 228980), an uncommon disorder. Fundus photographs revealed retinal flecks that affected her post-equatorial retina but spared the macular area. Fundus autofluorescence and infrared imaging demonstrated a symmetrical pattern of yellow-white fleck lesions that affected both eyes. Her full-field electroretinogram and electrooculogram were normal. An optical coherence tomography B-scan was performed for both eyes, revealing increased thickness of the retinal pigmented epithelium leading to multiple small pigmented epithelium detachments...
September 2017: Arquivos Brasileiros de Oftalmologia
https://www.readbyqxmd.com/read/29157363/detecting-structural-progression-in-glaucoma-with-optical-coherence-tomography
#4
Andrew J Tatham, Felipe A Medeiros
Optical coherence tomography (OCT) is increasingly used to obtain objective measurements of the retinal nerve fiber layer (RNFL), optic nerve head, and macula for assessing glaucoma progression. Although OCT has been adopted widely in clinical practice, uncertainty remains concerning its optimal role. Questions include: What is the best structure to measure? What quantity of change is significant? Are structural changes relevant to the patient? How are longitudinal measurements affected by aging? How can changes resulting from aging be differentiated from true progression? How best should OCT be used alongside visual fields, and how often should OCT be performed? Recent studies have addressed some of these questions...
December 2017: Ophthalmology
https://www.readbyqxmd.com/read/29155694/paracentral-acute-middle-maculopathy-in-primary-congenital-glaucoma
#5
Yavuz K Aribas, Zeynep Aktas, Kemal Bayrakceken, Tuba Atalay, Sengul Ozdek
PURPOSE: To report a case of primary congenital glaucoma associated with paracentral acute middle maculopathy. METHODS: A case report. RESULTS: A 14-year-old girl with undiagnosed primary congenital glaucoma was referred for the evaluation of sudden vision loss a week after the initial symptoms. Visual acuity was counting fingers at 2 m in the right eye. Examination of her right eye revealed corneal stromal scar like Haab striae, splinter hemorrhage at the temporal border of the optic disk, perivenular hemorrhage, and fern-like white area at the macula...
November 16, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/29152163/effect-of-aging-and-lifestyle-on-photoreceptors-and-retinal-pigment-epithelium-cross-sectional-study-in-a-healthy-danish-population
#6
Jacob Harris, Yousif Subhi, Torben L Sørensen
Photoreceptors and their supporting retinal pigment epithelium constitute the key functional parts of the retina. Here, a study was undertaken to show how aging and lifestyle factors affect the photoreceptor layer and the retinal pigment epithelium and Bruch's membrane complex (RPE-BM) in vivo in a healthy Danish population using spectral-domain optical coherence tomography. This was a cross-sectional study of healthy humans aged ≥50 years. All participants were interviewed for medical history and lifestyle factors...
2017: Pathobiology of Aging & Age related Diseases
https://www.readbyqxmd.com/read/29148528/why-the-macula
#7
REVIEW
A C Bird, D Bok
The regional susceptibility of the retina to diseases has been well known by clinicians for many years. It is surprising that the implications of these observations have not spawned major research efforts to characterise the structural and functional attributes of the outer retina in different regions of a foveate retina. Without such an effort, the understanding of the disease mechanisms in retinal dystrophies will remain limited and may hamper therapeutic efforts. That outer retinal disease is responsible for over 50% of blind registration in the western world underlines the importance of these considerations...
November 17, 2017: Eye
https://www.readbyqxmd.com/read/29148029/an-unusual-case-of-bilateral-pigmented-maculopathy-and-anterior-segment-dysgenesis
#8
Edward Bloch, Maria Pefkianaki, Jamil Hakim
PURPOSE: Pigmentary maculopathy can occur in the context of various inherited and acquired diseases. Anterior segment dysgenesis arises due to developmental anomalies and may be associated with systemic disease, as in Rieger syndrome. CASE REPORT: A 49-year-old woman presented with longstanding reduction in vision, evidence of anterior segment dysgenesis, and multiple discrete pigmented lesions throughout the macula bilaterally. Electroretinographic findings were consistent with severe macular dysfunction...
November 8, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/29142559/visual-and-anatomical-outcome-of-macular-hole-surgery-at-a-tertiary-healthcare-facility
#9
Komalta Kumari, Muhammad Ali Tahir, Alyscia Cheema
Objective: To assess visual and anatomical outcome of full thickness macular hole (FTMH) surgery with ILM peeling using brilliant blue G dye. Methods: Thirty patients who had clinically evident macular hole were selected. Pre-operative Optical Coherence Tomography (OCT) was done. In all cases vitrectomy was performed via 23guage 3 ports pars plana (3PPV) vitrectomy system and Brilliant blue G dye, 0.5ml dye was injected over macula which resulted in light blue stain of ILM and peeling was performed around hole in circular motion and after gas fluid exchange gas tamponade with SF6 was done...
September 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29137019/optical-coherence-tomography-angiography-in-patients-with-diabetic-retinopathy-treated-with-anti-vegf-intravitreal-injections-case-report
#10
Katarzyna Michalska-Małecka, Anna Heinke Knudsen
PURPOSE: To present optical coherence tomography angiography (OCTA) features in patients with diabetic retinopathy (DR) at the baseline and in response to treatment with anti-VEGF intravitreal injections. To investigate the role of OCTA in management of patients with DR. METHODS: Retrospective case series showing primary outcomes of 3 patients with DR and diabetic macular edema. Patients were injected intravitreally a loading phase of 3 monthly 2.0 mg aflibercept, followed by 2 injections bimonthly (5 injections in total)...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29135800/outcomes-of-pneumatic-retinopexy-performed-by-vitreoretinal-fellows
#11
Parisa Emami-Naeini, Vivian S Vuong, Steven Tran, Lawrence S Morse, Ala Moshiri, Susanna S Park, Glenn Yiu
PURPOSE: To evaluate the anatomical and visual outcomes of patients who underwent pneumatic retinopexy by vitreoretinal fellows. METHODS: We included 198 eyes (198 patients) that underwent pneumatic retinopexy by vitreoretinal fellows at a single academic institution between November 2002 and June 2016. Main outcomes were single-operation success and final anatomical success in retinal reattachment, as well as visual acuity at 3 months and 6 months after treatment...
November 10, 2017: Retina
https://www.readbyqxmd.com/read/29135799/peripapillary-pachychoroid-syndrome
#12
Nopasak Phasukkijwatana, K Bailey Freund, Rosa Dolz-Marco, Mayss Al-Sheikh, Pearse A Keane, Catherine A Egan, Sandeep Randhawa, Jay M Stewart, Qingyun Liu, Alex P Hunyor, Allan Kreiger, Aaron Nagiel, Robert Lalane, Mansour Rahimi, Won Ki Lee, Lee Merrill Jampol, David Sarraf
PURPOSE: To describe the features of peripapillary pachychoroid syndrome (PPS), a novel pachychoroid disease spectrum (PDS) entity. METHODS: Medical records of 31 eyes (16 patients) with choroidal thickening associated with intraretinal and/or subretinal fluid in the nasal macula extending from the disk were reviewed (patients with PPS). Choroidal thickness was compared with 2 age-matched cohorts: typical PDS (17 eyes with central serous chorioretinopathy or pachychoroid neovasculopathy) and 19 normal eyes...
November 10, 2017: Retina
https://www.readbyqxmd.com/read/29135703/a-case-of-relapsing-retinal-pigment-epithelial-detachment-in-peripapillary-pachychoroid-pigment-epitheliopathy
#13
Fuyan Zhang, Yuxing Qiu, Jay M Stewart
PURPOSE: To report the findings in a patient with peripapillary pachychoroid pigment epitheliopathy who demonstrated a retinal pigment epithelial detachment (PED) that was present at some times but not other times. METHODS: A review of 24 months of the clinical course and findings on multimodal imaging, including color fundus photography, fundus autofluorescence, spectral domain optical coherence tomography, and enhanced depth imaging optical coherence tomography...
November 10, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/29133665/a-rare-case-of-bilateral-tractional-retinal-detachment-following-snakebite
#14
Nicey Roy Thomas, Debmalya Das, Kumar Saurabh, Rupak Roy
A 13-year-old female presented with diminution of vision in both eyes for 3 months following snakebite. Best-corrected visual acuities were hand movement in both eyes. Fundoscopy showed vitreous hemorrhage, and B-scan ultrasonography revealed an underlying tractional retinal detachment (TRD) involving the macula in both eyes. Patient underwent 25-gauge pars plana vitrectomy in conjunction with belt buckling, endolaser, and silicone oil tamponade in the left eye. At 6 weeks postoperatively, best-corrected visual acuity of the left eye was noted to be 20/200 with settled TRD and attached retina...
November 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29131901/comparison-of-foveal-macular-and-peripapillary-intraretinal-thicknesses-between-autism-spectrum-disorder-and-neurotypical-subjects
#15
José Javier García-Medina, María García-Piñero, Mónica Del-Río-Vellosillo, Jesarán Fares-Valdivia, Ana Belén Ragel-Hernández, Salvador Martínez-Saura, María Dolores Cárcel-López, Vicente Zanon-Moreno, María Dolores Pinazo-Duran, María Paz Villegas-Pérez
Purpose: To compare thicknesses of intraretinal layers segmented by spectral-domain optical coherence tomography (SD-OCT) between autism spectrum disorder (ASD) and neurotypical (NT) individuals. Methods: We performed 2 scans on 108 eyes from 54 participants (27 high-functioning ASD and 27 age- and sex-matched NT subjects): macular fast volume and peripapillary retinal nerve fiber layer (pRNFL). Macula was automatically segmented. The mean foveal and macular thickness of nine different layers and the thickness of nine pRNFL sectors were considered...
November 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29131696/risk-factors-for-discontinuation-of-treatment-for-neovascular-age-related-macular-degeneration
#16
Inger Westborg, Aldana Rosso
PURPOSE: To investigate risk factors for treatment discontinuation for neovascular age-related macular degeneration (nAMD). METHODS: Data from the Swedish Macula Register and the Skåne Healthcare Register are reported on the treatment received by 932 nAMD patients diagnosed 2013-2015. Treatment discontinuation is defined as having a termination visit or lacking a control or treatment visit during the period of 10-14 months after the diagnostic visit. The risk of treatment discontinuation during the first year is estimated using a Poisson model and a classification tree...
November 13, 2017: Ophthalmic Epidemiology
https://www.readbyqxmd.com/read/29126927/mechanisms-of-macular-edema-beyond-the-surface
#17
REVIEW
Alejandra Daruich, Alexandre Matet, Alexandre Moulin, Laura Kowalczuk, Michaël Nicolas, Alexandre Sellam, Pierre-Raphaël Rothschild, Samy Omri, Emmanuelle Gélizé, Laurent Jonet, Kimberley Delaunay, Yvonne De Kozak, Marianne Berdugo, Min Zhao, Patricia Crisanti, Francine Behar-Cohen
Macular edema consists of intra- or subretinal fluid accumulation in the macular region. It occurs during the course of numerous retinal disorders and can cause severe impairment of central vision. Major causes of macular edema include diabetes, branch and central retinal vein occlusion, choroidal neovascularization, posterior uveitis, postoperative inflammation and central serous chorioretinopathy. The healthy retina is maintained in a relatively dehydrated, transparent state compatible with optimal light transmission by multiple active and passive systems...
November 7, 2017: Progress in Retinal and Eye Research
https://www.readbyqxmd.com/read/29126757/quantifying-the-rate-of-ellipsoid-zone-loss-in-stargardt-disease
#18
Cindy X Cai, Jacob G Light, James T Handa
PURPOSE: To determine a reliable method of using the ellipsoid zone (EZ) on optical coherence tomography (OCT) to track disease progression in Stardgardt disease (STGD). DESIGN: retrospective reliability study METHODS: STGD patients with genetically confirmed ABCA4 gene mutations seen at the Wilmer Eye Institute with follow-up visits separated by at least 12 months were identified. Spectral domain optical coherence tomography (SD-OCT) macula volume scans centered at the fovea and fundus autofluorescence (FAF) images were obtained...
November 7, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29125147/retinal-layers-thickness-changes-following-epiretinal-membrane-surgery
#19
I Hecht, I Yeshurun, E Bartov, A Bar, Z Burgansky-Eliash, A Achiron
PurposeTo evaluate the time course of changes in the thickness of retinal layers after epiretinal membrane (ERM) removal surgery.MethodsA retrospective cohort study of patients following surgery for idiopathic ERM. We used new specialized image analysis software to create a thickness map of each retinal layer and analyzed changes during one year follow-up. Healthy fellow eyes were used as negative controls and the retina prior to surgery as positive control.ResultsTwenty-one patients were included with a mean age of 68±13 years...
November 10, 2017: Eye
https://www.readbyqxmd.com/read/29123029/phenotypic-dissection-of-the-mouse-ren-1-d-knockout-by-complementation-with-human-renin
#20
Charlotte Buckley, Robert J Nelson, Linda J Mullins, Matthew Gf Sharp, Stewart Fleming, Christopher J Kenyon, Sabrina Semprini, Dominik Steppan, Janos Peti-Peterdi, Armin Kurtz, Helen Christian, John J Mullins
Normal renin synthesis and secretion is important for the maintenance of juxtaglomerular apparatus architecture. Mice lacking a functional Ren-1(d) gene are devoid of renal juxtaglomerular cell granules and exhibit an altered macula densa morphology. Due to the species-specificity of renin activity, transgenic mice are ideal models for experimentally investigating and manipulating expression patterns of the human renin gene in a native cellular environment without confounding Renin-angiotensin-system interactions...
November 9, 2017: Journal of Biological Chemistry
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