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Peptic ulcer disease

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https://www.readbyqxmd.com/read/29138097/gastric-microbiota-an-emerging-player-in-helicobacter-pylori-induced-gastric-malignancies
#1
J Luis Espinoza, Ayumi Matsumoto, Hirokazu Tanaka, Itaru Matsumura
The complex diversity of nonpathogenic microbes that colonize the human body, known as microbiota, exert considerable effects on physiological homeostasis, and immune regulation. Helicobacter pylori (H. pylori) is a bacterium that frequently colonizes human stomach and is a major pathogenic agent for peptic ulcer diseases, gastric cancer, and mucosa-associated lymphoid tissue (MALT) lymphoma. Due to its acidic pH and peristaltic movements, the stomach has been considered a hostile environment for most microorganisms, however various commensal microorganisms are capable of colonizing the stomach to form a stomach niche...
November 11, 2017: Cancer Letters
https://www.readbyqxmd.com/read/29121447/in-vitro-in-silico-elucidation-of-antiurease-activity-kinetic-mechanism-and-cox-2-inhibitory-efficacy-of-coagulansin-a-of-withania-coagulans
#2
Abdul Rehman Phull, Mubshir Hassan, Qamar Abbas, Hussain Raza, Ihsan Ul Haq, Sung Yum Seo, Song Ja Kim
Urease enzyme plays a crucial role in the survival of Helicobacter pylori that contributes to different diseases, including peptic ulcer. Coagulansin-A is the steroidal lactone found in plants of solanaceae family such Withania coagulans. The current study was carried out to examine the in vitro urease, COX-2 inhibitory activity and effect on type II collagen expression of coagulansin-A. Moreover, we investigated cytotoxic effects on rabbit articular chondrocytes through MTT assay. COX-2 and type II collagen expressions were determined through a western blotting...
November 9, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/29117862/successful-medical-management-of-acute-mesenteric-ischemia-due-to-superior-mesenteric-and-portal-vein-thrombosis-in-a-27-year-old-man-with-protein-s-deficiency-a-case-report
#3
N P Osti, D N Sah, R S Bhandari
BACKGROUND: Acute mesenteric ischemia poses a diagnostic challenge due to nonspecific clinical clues and lack of awareness owing to its rarity. Ischemia due to mesenteric venous thrombosis has a good prognosis compared to arterial cause and can be managed conservatively with early diagnosis. The portomesenteric venous system is an unusual site of thrombosis in patients with protein S deficiency, and its thrombosis is an uncommon cause of acute mesenteric ischemia. CASE PRESENTATION: We present a case of a 27-year-old Mongolian man who presented with acute abdominal pain increasing in severity, and refractory to repeated attempts at treatment with a misdiagnosis of acute peptic ulcer disease...
November 9, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29114188/chronic-disease-prevalence-among-elderly-saudi-men
#4
Nazmus Saquib, Juliann Saquib, Abdulrahman Alhadlag, Mohamad Anas Albakour, Bader Aljumah, Mohammed Sughayyir, Ziad Alhomidan, Omar Alminderej, Mohamed Aljaser, Abdulrahman Al-Mazrou
Objective: Saudi demographic composition has changed because of increased life expectancy and decreased fertility rates. Little data are available about health conditions among older adults in Saudi Arabia, who are expected to represent 20% of the population by 2050. The study aim was to assess the prevalence and risk factors for chronic conditions among older Saudi men. Methods: The sample pertained to 400 men (age ≥55 years) from Buraidah, Al-Qassim. Research assistants recruited participants in all the mosques from the randomly selected neighborhoods (16 of 95)...
November 2017: International Journal of Health Sciences
https://www.readbyqxmd.com/read/29113359/hepatointestinal-complications-in-polycystic-kidney-disease
#5
Shih-Ting Huang, Ya-Wen Chuang, Tung-Min Yu, Cheng-Li Lin, Long-Bin Jeng
Background: The objective of this study was to determine the incidence of major hepatointestinal complications in patients with polycystic kidney disease (PKD). Methods: We analyzed the Taiwan National Health Insurance claims data (2000-2010) of 6031 patients with PKD and 23,976 non-PKD hospitalized controls. The control cohort was propensity score matched with the PKD cohort at a 1:4 ratio. All patients were followed up from the index date to the first inpatient diagnosis of hepatointestinal complications, death, or 31 December, 2011...
October 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/29107979/helicobacter-pylori-bab-characterization-in-clinical-isolates-from-bhutan-myanmar-nepal-and-bangladesh
#6
Shamshul Ansari, Evariste Tshibangu Kabamba, Pradeep Krishna Shrestha, Hafeza Aftab, Thein Myint, Lotay Tshering, Rabi Prakash Sharma, Nwe Ni, Than Than Aye, Phawinee Subsomwong, Tomohisa Uchida, Thawee Ratanachu-Ek, Ratha-Korn Vilaichone, Varocha Mahachai, Takashi Matsumoto, Junko Akada, Yoshio Yamaoka
BACKGROUND: Helicobacter pylori BabA is an important outer membrane protein that involves in the attachment to the gastric mucosa and enhances the virulence property of the bacterium. This study was aimed to characterize the bab genotypes, to evaluate its association with cagA, vacA and clinical diseases as well as degree of gastric inflammation. METHODS: H. pylori isolates from four countries were subjected for the characterization of bab. The locus specific forward and bab specific reverse primers were used to get the specific products by PCR, which could distinguish the three locus (A, B and C)...
2017: PloS One
https://www.readbyqxmd.com/read/29107816/long-term-follow-up-of-the-incidence-of-helicobacter-pylori
#7
Marion Rowland, Marguerite Clyne, Leslie Daly, Humphrey O'Connor, Billy Bourke, Gerard Bury, Tom O' Dowd, Lucy Connolly, James Ryan, Stephen Shovlin, Brendan Dolan, Brendan Drumm
OBJECTIVES: Helicobacter pylori (H. pylori) causes peptic ulcer disease and gastric cancer. Understanding the incidence of H. pylori could help guide research on potential infection prevention strategies. Previous studies indicate infection occurs in young children, but the risk of infection in older children and adolescents is unclear. Our hypothesis was that H. pylori infection is rare in adolescence or adulthood. Our aim was to determine the incidence of H. pylori over a prolonged follow-up in a cohort of 626 non-infected individuals...
October 28, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29101296/stopping-antithrombotic-therapy-after-acute-upper-gastrointestinal-bleeding-is-associated-with-reduced-survival
#8
Keith Siau, Jack L Hannah, James Hodson, Monika Widlak, Neeraj Bhala, Tariq H Iqbal
INTRODUCTION: Antithrombotic drugs are often stopped following acute upper gastrointestinal bleeding (AUGIB) and frequently not restarted. The practice of antithrombotic discontinuation on discharge and its impact on outcomes are unclear. OBJECTIVE: To assess whether restarting antithrombotic therapy, prior to hospital discharge for AUGIB, affected clinical outcomes. DESIGN: Retrospective cohort study. SETTING: University hospital between May 2013 and November 2014, with median follow-up of 259 days...
November 3, 2017: Postgraduate Medical Journal
https://www.readbyqxmd.com/read/29066874/optimization-of-drug-therapy-in-elderly-individuals-admitted-to-a-geriatric-unit
#9
Antoine Piau, Yoann Huet, Adeline Gallini, Laurine Andre, Bruno Vellas, Fati Nourhashemi
BACKGROUND: A substantial share of adverse drug events involves inappropriate prescribing (IP). Specialized geriatric units are supposed to pay particular attention to prescribing appropriateness and to promoting a higher prescribing quality. OBJECTIVE: The objective of this study was to evaluate the reality of such assessment and optimization in real life (usual care) in a population of elderly individuals admitted to a geriatric unit. METHOD: This is an observational study including all older patients admitted to an acute geriatric unit over a 6-month period...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29064799/gastroesophageal-reflux-disease-the-results-of-videolaparoscopic-fundoplication-at-five-years-after-surgery
#10
Andriy R Stasyshyn
INTRODUCTION: GERD reduces social activity and significantly affects the quality of life (QOL) of patients and the risk of complications (cancer of the esophagus, esophageal-gastric bleeding, strictures, perforation) is one of the most pressing problems of medicine of XXI century. The aim of the research is to evaluate the results of videolaparoscopic fundoplication at five years after surgery in patients with gastroesophageal reflux disease. MATERIAL AND METHODS: We studied results of videolaparoscopic antireflux surgery (VLAS) during 2009-2016 years in Department of Surgery and Endoscopy Faculty of postgraduate medical education Lviv National Medical University...
2017: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29062455/laparoscopic-pyloroplasty-for-perforated-peptic-ulcer
#11
Edvard Grišin, Saulius Mikalauskas, Tomas Poškus, Valdemaras Jotautas, Kęstutis Strupas
Peptic ulcer is a common disease affecting millions of people every year. Despite improved understanding and treatment of the disease, the number of patients admitted with duodenal peptic ulcer perforation has not decreased. Deaths from peptic ulcer disease overcome other common emergency situations. Laparoscopic repair of the perforated peptic ulcer (PPU) is the gold standard approach for simple perforation. However, in patients with large perforated chronic ulcers laparotomy with pyloroplasty is the standard treatment...
September 2017: Wideochirurgia i Inne Techniki Mało Inwazyjne, Videosurgery and Other Miniinvasive Techniques
https://www.readbyqxmd.com/read/29062238/structural-and-functional-characterization-of-the-helicobacter-pylori-cytidine-5-monophosphate-pseudaminic-acid-synthase-psef-molecular-insight-into-substrate-recognition-and-catalysis-mechanism
#12
Syeda Umme Habiba Wahid
The bacterium Helicobacter pylori is a human gastric pathogen that can cause a wide range of diseases, including chronic gastritis, peptic ulcer and gastric carcinoma. It is classified as a definitive (class I) human carcinogen by the International Agency for Research on Cancer. Flagella-mediated motility is essential for H. pylori to initiate colonization and for the development of infection in human beings. Glycosylation of the H. pylori flagellum with pseudaminic acid (Pse; 5,7-diacetamido-3,5,7,9-tetradeoxy-l-glycero-l-manno-nonulosonic acid) is essential for flagella assembly and function...
2017: Advances and Applications in Bioinformatics and Chemistry: AABC
https://www.readbyqxmd.com/read/29055500/long-term-systemic-corticosteroid-exposure-a-systematic-literature-review
#13
REVIEW
J Bradford Rice, Alan G White, Lauren M Scarpati, George Wan, Winnie W Nelson
PURPOSE: While corticosteroids are relatively inexpensive and commonly used as treatment for a variety of conditions, long-term use is known to be associated with certain toxicities. Prior systematic reviews have revealed an increased risk for costly adverse events (AEs), including bone fracture, infection, and gastrointestinal bleeding. The objective of this study was to conduct a systematic literature review of recent publications on the burden of long-term corticosteroid exposure, specifically, to summarize the AEs and economic impact of long-term corticosteroid use and to reveal data gaps for additional research...
October 18, 2017: Clinical Therapeutics
https://www.readbyqxmd.com/read/29048469/resilience-to-stress-and-risk-of-gastrointestinal-infections
#14
Carren Melinder, Ayako Hiyoshi, Teresa Kasiga, Jonas Halfvarson, Katja Fall, Scott Montgomery
Background: Exposure to psychological stress can elicit a physiological response that may influence characteristics of the gastrointestinal mucosa, including increased intestinal permeability, in turn possibly increasing susceptibility to gastrointestinal infections. We investigated whether low stress resilience in adolescence is associated with an 'increased' risk of gastrointestinal infections in subsequent adulthood. Methods: Data were provided by Swedish registers for a cohort of 237 577 men who underwent military conscription assessment in late adolescence (1969-76)...
October 18, 2017: European Journal of Public Health
https://www.readbyqxmd.com/read/29032119/a-systematic-review-of-safety-and-efficacy-of-systemic-corticosteroids-in-atopic-dermatitis
#15
Sherry Yu, Aaron M Drucker, Mark Lebwohl, Jonathan I Silverberg
BACKGROUND: Systemic corticosteroids are often used to treat atopic dermatitis (AD). However, few studies assessed the safety and efficacy of systemic corticosteroids in AD. OBJECTIVE: To systematically review the literature on efficacy and safety of systemic corticosteroid use (oral, intramuscular, intravenous) in AD. METHODS: PubMed, Embase, Medline, Scopus, Web of Science, and Cochrane Library were searched. We included systematic reviews, guidelines and treatment reviews of systemic corticosteroid use among patients of all ages with a diagnosis of AD (52 reviews and 12 studies)...
October 12, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29026467/chromogranin-a-as-a-biochemical-marker-for-neuroendocrine-tumors-a-single-center-experience-at-royal-hospital-oman
#16
Elham S Al-Risi, Fatma S Al-Essry, Waad-Allah S Mula-Abed
OBJECTIVES: To evaluate the significance of serum chromogranin A (CgA) status in patients with and without different neuroendocrine tumors (NETs) by conducting a retrospective assessment of the diagnostic utility and limitations of CgA as a biomarker for NETs in a tertiary care hospital in Oman. METHODS: We conducted a retrospective analysis of CgA requests referred to the Clinical Biochemistry Laboratory, Royal Hospital, Oman over a 24-month period (April 2012 to March 2014)...
September 2017: Oman Medical Journal
https://www.readbyqxmd.com/read/28993832/-diagnostics-and-treatment-of-primary-hyperparathyroidism
#17
C Nies
Primary hyperparathyroidism is a disease that occurs more frequently than generally thought and is often overlooked. Classical symptoms are bone pain and osteoporosis, renal calculi and peptic ulcers. Many patients are asymptomatic or have unspecific complaints. It is easy to establish the biochemical diagnosis based on calcium and parathormone (PTH) levels and 24-h urine calcium excretion. The most sensitive localization procedures for parathyroid adenomas are sonography and Tc-99(m)-MIBI scintigraphy. The indication for surgery is undisputed in symptomatic patients; however, there is controversy concerning patients without classical symptoms...
October 9, 2017: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/28992891/patterns-of-medical-utilization-before-the-first-hospitalization-for-women-with-anorexia-nervosa-in-taiwan
#18
Yen-Ni Hung, Chian-Jue Kuo, Shu-Yu Yang, Ming-Chyi Huang, Ying-Yeh Chen, Shih-Ku Lin, Kuan-Yu Chen
OBJECTIVE: The aim of this paper was to analyze medical utilization patterns of female patients with anorexia nervosa before their first inpatient care visit for anorexia nervosa using the National Health Insurance Research Database (NHIRD) of Taiwan. METHOD: We selected female anorexia nervosa patients (n=239) and control participants hospitalized for peptic ulcers (n=478) or appendectomy (n=478) who were matched by age and incident year from two subsets of the NHIRD...
November 2017: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/28988020/management-of-mediastinal-parathyroid-adenoma-via-minimally-invasive-thoracoscopic-surgery-case-report
#19
Saulat Hasnain Fatimi, Hina Inam, Farida Karim Chagan, Usama Khalid Choudry
INTRODUCTION: The most common cause of chronic hypercalcemia is primary hyperparathyroidism (PHPT). However, owing to the diverse presentation of hypercalcemia, the diagnosis often goes unnoticed culminating as a continuum of recurrence of symptoms. Nephrolithiasis, decreased bone mineral density and peptic ulcer disease are the main clinical sequelae. Among the causes of PHPT 80% are caused by parathyroid adenomas (PA). However, only rarely, these adenomas are found ectopically. PRESENTATION OF CASE: We present the case of a 66-year-old female with a history of recurrent renal stones and peptic ulcer disease...
2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28984645/advances-in-the-endoscopic-management-of-gastric-outflow-disorders
#20
Andrew C Storm, Marvin Ryou
PURPOSE OF REVIEW: Disorders of gastric outflow and outlet obstruction include a variety of benign and malignant disorders such as peptic strictures, foreign bodies, gastroparesis, and cancers of the stomach, duodenum, and pancreas. Historically, a majority of patients presenting with gastric outlet obstruction (GOO) were to the result of peptic ulcers and surgical management of peptic ulcer complications was a mainstay of general surgical training. Invasive surgery is being performed less frequently today due to realization of the role of Helicobacter pylori in peptic ulcer disease and the introduction of novel endoscopic techniques for management of GOO...
November 2017: Current Opinion in Gastroenterology
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