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https://www.readbyqxmd.com/read/28230770/vegfa-impacts-early-myocardium-development-in-zebrafish
#1
Diqi Zhu, Yabo Fang, Kun Gao, Jie Shen, Tao P Zhong, Fen Li
Vascular endothelial growth factor A (Vegfa) signaling regulates cardiovascular development. However, the cellular mechanisms of Vegfa signaling in early cardiogenesis remain poorly understood. The present study aimed to understand the differential functions and mechanisms of Vegfa signaling in cardiac development. A loss-of-function approach was utilized to study the effect of Vegfa signaling in cardiogenesis. Both morphants and mutants for vegfaa display defects in cardiac looping and chamber formation, especially the ventricle...
February 21, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28230187/silencing-salusin-%C3%AE-attenuates-cardiovascular-remodeling-and-hypertension-in-spontaneously-hypertensive-rats
#2
Xing-Sheng Ren, Li Ling, Bing Zhou, Ying Han, Ye-Bo Zhou, Qi Chen, Yue-Hua Li, Yu-Ming Kang, Guo-Qing Zhu
Salusin-β is a bioactive peptide involved in vascular smooth muscle cell proliferation, vascular fibrosis and hypertension. The present study was designed to determine the effects of silencing salusin-β on hypertension and cardiovascular remodeling in spontaneously hypertensive rats (SHR). Thirteen-week-old male SHR and normotensive Wistar-Kyoto rats (WKY) were subjected to intravenous injection of PBS, adenoviral vectors encoding salusin-β shRNA (Ad-Sal-shRNA) or a scramble shRNA. Salusin-β levels in plasma, myocardium and mesenteric artery were increased in SHR...
February 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28229910/optimized-energy-of-spectral-ct-for-infarct-imaging-experimental-validation-with-human-validation
#3
Veit Sandfort, Srikanth Palanisamy, Rolf Symons, Amir Pourmorteza, Mark A Ahlman, Kelly Rice, Tom Thomas, Cynthia Davies-Venn, Bernhard Krauss, Alan Kwan, Ankur Pandey, Stefan L Zimmerman, David A Bluemke
OBJECTIVES: Late contrast enhancement visualizes myocardial infarction, but the contrast to noise ratio (CNR) is low using conventional CT. The aim of this study was to determine if spectral CT can improve imaging of myocardial infarction. MATERIALS AND METHODS: A canine model of myocardial infarction was produced in 8 animals (90-min occlusion, reperfusion). Later, imaging was performed after contrast injection using CT at 90 kVp/150 kVpSn. The following reconstructions were evaluated: Single energy 90 kVp, mixed, iodine map, multiple monoenergetic conventional and monoenergetic noise optimized reconstructions...
February 11, 2017: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/28229640/effect-of-cerebrolysin-on-oxidative-stress-induced-apoptosis-in-an-experimental-rat-model-of-myocardial-ischemia
#4
V Boshra, A Atwa
Apoptosis plays a role in the process of tissue damage after myocardial infarction (MI). This study was designed to investigate the possible effect of cerebrolysin against apoptosis triggered by oxidative cell stress in myocardial ischemia induced by isoproterenol in rat. Rats were pretreated with cerebrolysin 5 mL/kg intraperitoneally for 7 days and intoxicated with isoproterenol (ISO, 85 mg/kg, sc) on the last 2 days. Hearts were excised and stained to detect the infarction size. Serum levels of cardiotoxicity indices as creatine kinase isoenzyme (CK-MB) and troponin I (cTnI) as well as the cardiac oxidative stress parameters as thiobarbituric acid reactive substances and superoxide dismutase were estimated...
September 2016: Physiol Int
https://www.readbyqxmd.com/read/28229425/optimal-environmental-stiffness-for-stem-cell-mediated-ischemic-myocardium-repair
#5
Honghai Liu, Christian Paul, Meifeng Xu
Cardiovascular diseases related to myocardial infarction (MI) contribute significantly to morbidity and mortality worldwide. The loss of cardiomyocytes during MI is a key factor in the impairment of cardiac-pump functions. Employing cell transplantation has shown great potential as a therapeutic approach in regenerating ischemic myocardium. Several studies have suggested that the therapeutic effects of stem cells vary based on the timing of cell administration. It has been clearly established that the myocardium post-infarction experiences a time-dependent stiffness change, and many studies have highlighted the importance of stiffness (elasticity) of microenvironment on modulating the fate and function of stem cells...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28229312/routine-18-f-fdg-pet-ct-does-not-detect-inflammation-in-the-left-atrium-in-patients-with-atrial-fibrillation
#6
Philipp S Lange, Nemanja Avramovic, Gerrit Frommeyer, Kristina Wasmer, Christian Pott, Lars Eckardt, Christian Wenning
Increasing evidence supports a role of inflammation in the development of atrial fibrillation (AF). However, direct evidence of persistent inflammatory activity in the atria of AF patients is scarce. In this study, we used 18-Fluor-Deoxyglucose positron emission tomography computed tomography ((18)F-FDG PET/CT) to determine atrial inflammation in patients with and without AF. Retrospectively, (18)F-FDG PET/CT scans were analyzed. 37 patients with a history of AF were compared to an age and sex matched control group with no history of AF...
February 22, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28228941/renal-ischemia-reperfusion-induced-cardiac-hypertrophy-in-mice-cardiac-morphological-and-morphometric-characterization
#7
Rogério Cirino-Silva, Fernanda V Kmit, Mayra Trentin-Sonoda, Karina K Nakama, Karine Panico, Juliana M Alvim, Thiago R Dreyer, Herculano Martinho-Silva, Marcela S Carneiro-Ramos
BACKGROUND: Tissue remodeling is usually dependent on the deposition of extracellular matrix that may result in tissue stiffness and impaired myocardium contraction. OBJECTIVES: We had previously demonstrated that renal ischemia/reperfusion (I/R) is able to induce development of cardiac hypertrophy in mice. Therefore, we aimed to characterize renal I/R-induced cardiac hypertrophy. DESIGN: C57BL/6 J mice were subjected to 60 minutes' unilateral renal pedicle occlusion, followed by reperfusion (I/R) for 5, 8, 12 or 15 days...
January 2017: JRSM Cardiovascular Disease
https://www.readbyqxmd.com/read/28227762/single-shot-turbo-spin-echo-acquisition-for-in-vivo-cardiac-diffusion-mri
#8
Masoud Edalati, Gregory R Lee, Hui Wang, Michael D Taylor, Yu Y Li, Masoud Edalati, Gregory R Lee, Hui Wang, Michael D Taylor, Yu Y Li, Masoud Edalati, Gregory R Lee, Michael D Taylor, Hui Wang, Yu Y Li
Diffusion MRI offers the ability to noninvasively characterize the microstructure of myocardium tissue and detect disease related pathology in cardiovascular examination. This study investigates the feasibility of in vivo cardiac diffusion MRI under free-breathing condition. A high-speed imaging technique, correlation imaging, is used to enable single-shot turbo spin echo for free-breathing cardiac data acquisition. The obtained in vivo cardiac diffusion-weighted images illustrate robust image quality and minor geometry distortions...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227429/characterization-of-normal-and-scarred-myocardium-based-on-texture-analysis-of-cardiac-computed-tomography-images
#9
S Antunes, A Esposito, A Palmisanov, C Colantoni, F de Cobelli, A Del Maschio, S Antunes, A Esposito, A Palmisanov, C Colantoni, F de Cobelli, A Del Maschio, A Del Maschio, C Colantoni, F De Cobelli, A Esposito, S Antunes
An accurate detection of myocardial scar using Cardiac CT may have a strong clinical impact; however, the main drawback is the insufficient contrast to noise ratio of delayed iodine enhanced (DIE) CT images, which makes its accurate segmentation (manual as well as automatic) difficult. In this work, we investigate texture parameters applied on the different scans in order to obtain the scans and features that best differentiates normal from scarred myocardium. The experiments on 7 cases of myocarditis show the accuracy of the parameter energy in all scans, as well as the good performance of the angiographic scan (having higher spatial resolution) with different parameters for the segmentation propose...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227343/application-of-a-new-robust-ecg-t-wave-delineation-algorithm-for-the-evaluation-of-the-autonomic-innervation-of-the-myocardium
#10
Matteo Cesari, Jesper Mehlsen, Anne-Birgitte Mehlsen, Helge Bjarup Dissing Sorensen, Matteo Cesari, Jesper Mehlsen, Anne-Birgitte Mehlsen, Helge Bjarup Dissing Sorensen, Jesper Mehlsen, Helge Bjarup Dissing Sorensen, Matteo Cesari, Anne-Birgitte Mehlsen
T-wave amplitude (TWA) is a well know index of the autonomic innervation of the myocardium. However, until now it has been evaluated only manually or with simple and inefficient algorithms. In this paper, we developed a new robust single-lead electrocardiogram (ECG) T-wave delineation algorithm that is able to detect the T-wave with a wavelet based method and automatically calculate the TWA. We evaluated the algorithm on the QT database, achieving a sensitivity of 99.92% for the T wave peak and 99.38% for the T wave end...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226918/gyrocardiography-a-new-non-invasive-approach-in-the-study-of-mechanical-motions-of-the-heart-concept-method-and-initial-observations
#11
Mojtaba Jafari Tadi, Eero Lehtonen, Mikko Pankaala, Antti Saraste, Tuija Vasankari, Mika Teras, Tero Koivisto, Mojtaba Jafari Tadi, Eero Lehtonen, Mikko Pankaala, Antti Saraste, Tuija Vasankari, Mika Teras, Tero Koivisto, Eero Lehtonen, Mojtaba Jafari Tadi, Mika Teras, Antti Saraste, Tuija Vasankari, Mikko Pankaala, Tero Koivisto
The pumping action of the heart is performed by contraction of the myocardium fibers. We present a non-invasive technique named gyrocardiography (GCG) that comprises a sensor of angular motion, gyroscope, configured to obtain three-dimensional angular velocity signals. A tri-axial micro electromechanical (MEMS) gyroscope sensor was attached to the surface of the chest to obtain gyrocardiogram. Color-coded Doppler tissue imaging (DTI) was recorded simultaneously and synchronized with the GCG in an off-line analysis...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28225836/analysis-of-immune-cell-populations-in-atrial-myocardium-of-patients-with-atrial-fibrillation-or-sinus-rhythm
#12
Natalia Smorodinova, Martin Bláha, Vojtěch Melenovský, Karolína Rozsívalová, Jaromír Přidal, Mária Ďurišová, Jan Pirk, Josef Kautzner, Tomáš Kučera
BACKGROUND: Atrial fibrillation (AF) is the most common arrhythmia and despite obvious clinical importance remains its pathogenesis only partially explained. A relation between inflammation and AF has been suggested by findings of increased inflammatory markers in AF patients. OBJECTIVE: The goal of this study was to characterize morphologically and functionally CD45-positive inflammatory cell populations in atrial myocardium of patients with AF as compared to sinus rhythm (SR)...
2017: PloS One
https://www.readbyqxmd.com/read/28225063/targeted-inhibition-of-focal-adhesion-kinase-attenuates-cardiac-fibrosis-and-preserves-heart-function-in-adverse-cardiac-remodeling
#13
Jie Zhang, Guangpu Fan, Hui Zhao, Zhiwei Wang, Fei Li, Peide Zhang, Jing Zhang, Xu Wang, Wei Wang
Cardiac fibrosis in post-myocardial infarction (MI), seen in both infarcted and non-infarcted myocardium, is beneficial to the recovery of heart function. But progressively pathological fibrosis impairs ventricular function and leads to poor prognosis. FAK has recently received attention as a potential mediator of fibrosis, our previous study reported that pharmacological inhibition of FAK can attenuate cardiac fibrosis in post MI models. However, the long-term effects on cardiac function and adverse cardiac remodelling were not clearly investigated...
February 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28224816/protective-effect-of-curcumin-against-myocardium-injury-in-ischemia-reperfusion-rats
#14
HuaJin Liu, ChangHua Wang, Zengyong Qiao, Yawei Xu
CONTEXT: Curcumin has long been used as a condiment and a traditional medicine worldwide. OBJECTIVE: The current study investigates the possible protective effect of curcumin on heart function in myocardium ischemia-reperfusion (MIR) rats. MATERIALS AND METHODS: We fed Sprague-Dawley (SD) rats (10 in each group) either curcumin (10, 20 or 30 mg/kg/d) or saline. Twenty days later, the rats were subjected to myocardial injuries by ligating the left anterior descending coronary artery (60 min), and subsequently, the heart (3 h) reperfused by releasing the ligation...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28223053/diabetes-upregulation-of-cyclooxygenase-2%C3%A2-contributes-to-altered-coronary-reactivity-after-cardiac-surgery
#15
Jun Feng, Kelsey Anderson, Arun K Singh, Afshin Ehsan, Hunter Mitchell, Yuhong Liu, Frank W Sellke
BACKGROUND: We hypothesized that upregulation of inducible cyclooxygenase 2 (COX-2) contributes to altered coronary arteriolar reactivity early after cardioplegic arrest and cardiopulmonary bypass (CP/CPB) in patients with diabetes mellitus who are undergoing cardiac surgery. METHODS: The right atrial tissue samples of nondiabetes (ND), controlled diabetes (CDM), and uncontrolled diabetes (UDM) patients undergoing cardiac surgery were harvested before and after CP/CPB...
February 18, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28222157/dexmedetomidine-preconditioning-may-attenuate-myocardial-ischemia-reperfusion-injury-by-down-regulating-the-hmgb1-tlr4-myd88-nf-%C3%B0%C2%BAb-signaling-pathway
#16
Jing-Jing Zhang, Ke Peng, Juan Zhang, Xiao-Wen Meng, Fu-Hai Ji
AIMS: To investigate whether dexmedetomidine (DEX) preconditioning could alleviate the inflammation caused by myocardial ischemia/reperfusion (I/R) injury by reducing HMGB1-TLR4-MyD88-NF-кB signaling. METHODS: Seventy rats were randomly assigned into five groups: sham group, myocardial I/R group (I/R), DEX+I/R group (DEX), DEX+yohimbine+I/R group (DEX/YOH), and yohimbine+I/R group (YOH). Animals were subjected to 30 min of ischemia induced by occluding the left anterior descending artery followed by 120 min of reperfusion...
2017: PloS One
https://www.readbyqxmd.com/read/28219936/cardioprotection-of-ischemic-preconditioning-in-rats-involves-upregulating-adiponectin
#17
Hui Wang, Wenjing Wu, Jun Duan, Ming Ma, Wei Kong, Yuannan Ke, Gang Li, Jingang Zheng
It has been reported that ischemic preconditioning (IPC) and adiponectin (APN) are cardioprotective in many cardiovascular disorders. However, whether APN mediates the effect of IPC on myocardial injury has not been elucidated. This study was conducted to investigate whether IPC affects myocardial ischemic injury by increasing APN expression. Male adult rats with cardiac knockdowns of APN and its receptors via intramyocardial small-interfering RNA injection were subjected to IPC and then myocardial infarction (MI) at 24 h post-IPC...
February 20, 2017: Journal of Molecular Endocrinology
https://www.readbyqxmd.com/read/28219711/oxidative-stress-inactivates-ecto-5-nucleotidase-by-inhibiting-protein-kinase-c-in-rat-hearts-in-vivo
#18
Toshio Obata, Michiko Nakashima
Examined in the present study, allopurinol are xanthine oxidase inhibitors for use in rat hearts in vivo dialysis technology and ventricular myocardial intersitial adenosine production can increase. The microdialysis probe was implanted in the left ventricular myocardium of anesthetized rat hearts and the tissue in the vicinity of the dialysis was perfused with Tyrode's solution containing adenosine 5'-monophosphate (AMP) through the dialysis probe at a rate of 1.0ml/min to assess the activity of ecto-5'-nucleotidase...
February 17, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28219578/valved-conduit-attached-to-left-ventricular-outflow-tract-for-valve-detachment-in-beh%C3%A3-et-s-disease
#19
Liang-Wan Chen, Xi-Jie Wu, Hua Cao, Xiao-Fu Dai
Standard aortic valve replacement for aortic regurgitation caused by Behçet's disease is frequently complicated by postoperative recurrent prosthetic valve detachment. To prevent this, we have developed a modified Bentall procedure, in which the valved conduit is proximally attached to the left ventricular outflow tract instead of to the fragile annulus, based on the fact that the left ventricular outflow tract myocardium is rarely involved in Behçet's disease. This modified Bentall procedure was performed in 5 Behçet's disease patients with prosthetic valve detachment after primary aortic valve replacement, and satisfactory results were achieved...
March 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28219198/-effects-and-mechanisms-of-ursodeoxycholic-acid-on-isoprenaline-induced-myocardial-fibrosis-in-mice
#20
X Li, K Q Han, Y N Shi, S Z Men, S Li, M H Sun, H Dong, J J Lu, L J Ma, M Zhao, D Li, W Liu
Objective: To investigate the effects and possible mechanisms of ursodeoxycholic acid (UDCA) on myocardial fibrosis in mice. Method: To observe the expression of transforming growth factor(TGF) -β1, CTGF, MMPs and the degree of myocardial fibrosis, 61 male Kunming mice were randomly divided into normal group, low dose UDCA group, high dose of UDCA group, spironolactone group, and the control group.Isoproterenol (ISO) injection was given subcutaneously (30 d) to make the model of myocardial fibrosis.Corresponding anti-fibrosis drugs (UDCA or spironolactone) were given by gavage...
February 7, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
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