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Saeed Mehrzadi, Iman Fatemi, Ali Reza Malayeri, Ali Khodadadi, Fatemeh Mohammadi, Esrafil Mansouri, Mohammad Rashno, Mehdi Goudarzi
BACKGROUND: The aim of this study was to investigate the effect of ellagic acid (EA) on arsenic-induced renal and hepatic toxicity in rats. METHODS: A total number of 35 male Wistar rats were randomly divided into five experimental groups. Group 1 received normal saline (po). Group 2 received sodium arsenite (SA, 10 mg/kg, po) for 21 days. Group 3 received EA (30 mg/kg, po) for 14 days. Groups 4 and 5 received SA 7 days prior to EA (10 and 30 mg/kg respectively) treatment and continued up to 21 days simultaneous with SA administration...
February 5, 2018: Pharmacological Reports: PR
Jose Carlos Dayoub, Franco Cortese, Andreja Anžič, Tjaša Grum, João Pedro de Magalhães
Despite the considerable amount of data available on the effect of donor age upon the outcomes of organ transplantation, these still represent an underutilized resource in aging research. In this review, we have compiled relevant studies that analyze the effect of donor age in graft and patient survival following liver, kidney, pancreas, heart, lung and cornea transplantation, with the aim of deriving insights into possible differential aging rates between the different organs. Overall, older donor age is associated with worse outcomes for all the organs studied...
June 20, 2018: Experimental Gerontology
Qing Wang, Henglong Hu, Najib Isse Dirie, Yuchao Lu, Jiaqiao Zhang, Lei Cui, Baolong Qin, Yufeng Wang, Jianning Zhu, Yang Xun, Yunpeng Zhu, Yue Wu, Shaogang Wang
OBJECTIVE: To address whether matrix Gla protein (MGP) can inhibit mineralization in normal rat kidney tubular cells (NRK-52E) under high concentration of calcium. MATERIALS AND METHODS: NRK52E cells were treated with high concentration of calcium. The viability and apoptosis of cells were detected by cell counting kit-8 and flow cytology respectively. RT-PCR, Western blotting and immunofluorescence analysis were conducted to detect the expression of MGP. Cells were transfected with plasmid-MGP or siRNA-MGP for up- or down-regulation the expression of MGP respectively...
June 20, 2018: Urology
İlker Öngüç Aycan, Özlem Elpek, Bahar Akkaya, Ebru Kıraç, Hazal Tuzcu, Sabriye Kaya, Nesil Coşkunfırat, Mutay Aslan
The aim of this study was to investigate whether thymoquinone (TQ) could alleviate diclofenac (DCLF)-induced gastrointestinal and renal toxicity in rats. Diclofenac was administered via intramuscular injection twice daily for 5 days and TQ was given by gavage for the same period. Hematological and biochemical profiles were measured with autoanalyzers while reactive oxygen/nitrogen species (ROS/RNS) generation and total antioxidant capacity (TAC) were assayed by standard kits. Tissue injuries were evaluated by microscopy and histopathological scoring...
June 20, 2018: Food and Chemical Toxicology
Zuohui Zhao, Jiaju Lu, Hongyi Qu, Zunsong Wang, Qiang Liu, Xiaoqing Yang, Shuai Liu, Juntao Ge, Yue Xu, Na Li, Yijiao Yuan
The antioxidant enzyme manganese superoxide dismutase (MnSOD) is upregulated in renal cell carcinoma (RCC) and has been implicated in multiple stages of RCC tumorigenesis and progression. However, the prognostic significance of MnSOD in RCC has not been fully elucidated. This study aimed to investigate the expression profile of MnSOD in clear cell RCC (ccRCC) tissues and evaluate the clinical significance of this enzyme in ccRCC patients. MnSOD mRNA was assessed in 42 ccRCC and 33 normal kidney tissues by the Oncomine database, and its protein was detected in 145 ccRCC and 3 normal tissues by immunohistochemistry staining (IHC)...
June 20, 2018: Human Pathology
Osamu Ichii, Teppei Nakamura, Taro Horino, Akira Yabuki, Yaser Hosny Ali Elewa, Yasuhiro Kon
The distal tubule (DT) helps regulate blood pressure and electrolytes. We describe a novel, autosomal recessive, morpho-functional DT abnormality in inbred mice evident as columnar alternations and age-related cystic changes. This abnormality developed in both sexes of DBA/2Cr mice. Similar phenotypes were observed in A/J, C3H/He, DBA/1J, and FVB/N strains, but not in AKR/N, BALB/c, or C57BL/6N strains. In DBA/2Cr mice, abnormal DT localized to straight and convoluted segments and showed interleukin (IL)-36α/IL-1F6 DT injury marker expression...
June 20, 2018: American Journal of Pathology
Maycon I O Milanez, Érika E Nishi, Alex Y S Sato, Henrique A Futuro Neto, Cássia T Bergamaschi, Ruy R Campos
The role of spinal cord neurons in renal sympathoexcitation remains unclear in renovascular hypertension, represented by the 2-kidney, 1-clip (2K1C) model. Thus, we aimed to assess the influence of spinal glutamatergic and AT1 angiotensin II receptors on renal sympathetic nerve activity (rSNA) in 2K1C Wistar rats. Hypertension was induced by clipping the renal artery with a silver clip. After six weeks, a catheter (PE-10) was inserted into the subarachnoid space and advanced to the T10-11 vertebral level in urethane-anaesthetized rats...
June 20, 2018: Brain Research
Yan Wang, Wenjing An, Fei Zhang, Mengzhen Niu, Yu Liu, Ruizan Shi
The aim was to evaluate the effects and mechanisms of nebivolol on renal damage in Zucker diabetic fatty (ZDF) rats, in comparison with those of atenolol and captopril. Animals were divided into: control lean Zucker rats, ZDF rats, ZDF rats orally treated with nebivolol (10 mg/kg), atenolol (100 mg/kg) or captopril (40 mg/kg) for 6 months. Systolic blood pressure (SBP), blood glucose, kidney structure and function, plasma and kidney levels of nitric oxide (NO) and asymmetric dimethylarginine (ADMA), and oxidant status were evaluated...
June 23, 2018: Clinical and Experimental Pharmacology & Physiology
Brandon M Kistler, Jagdish Khubchandani, Gina Jakubowicz, Kenneth Wilund, Jacob Sosnoff
INTRODUCTION: Falls are among the leading causes of injury and death among adults aged 65 or older. People with chronic kidney disease (CKD) are at increased risk of falling and of having a serious injury from falls. However, information is limited about risk factors for falls and fall-related injuries among people with CKD. METHODS: We performed a secondary analysis of 157,753 adults (6.1% with CKD) aged 65 or older surveyed in the 2014 Behavioral Risk Factor Surveillance System...
June 21, 2018: Preventing Chronic Disease
Carrie A Schinstock, Ruth Sapir-Pichhadze, Maarten Naesens, Ibrahim Batal, Serena Bagnasco, Laurine Bow, Patricia Campbell, Marian C Clahsen-van Groningen, Matthew Cooper, Emanuele Cozzi, Darshana Dadhania, Fritz Diekmann, Klemens Budde, Fritz Lower, Babak J Orandi, Ajda T Rowshani, Lynn Cornell, Edward Kraus
The aim of this study was to determine how the Banff antibody-mediated rejection (ABMR) classification for kidney transplantation is interpreted in practice and impacts therapy. The Banff Antibody-Mediated Injury Workgroup electronically surveyed clinicians and pathologists worldwide regarding diagnosis and treatment for six case-based scenarios. The participants' (95 clinicians and 72 renal pathologists) assigned diagnoses were compared to the Banff intended diagnoses (reference standard). The assigned diagnoses and reference standard differed by 26...
June 23, 2018: American Journal of Transplantation
Sunjae Bae, Allan B Massie, Alvin G Thomas, Gahyun Bahn, Xun Luo, Kyle R Jackson, Shane E Ottmann, Daniel C Brennan, Niraj M Desai, Josef Coresh, Dorry L Segev, Jacqueline M Garonzik Wang
The impact of donor quality on post-kidney transplant (KT) survival may vary by candidate condition. Characterizing this variation would increase access to KT without sacrificing outcomes. We developed a tool to estimate post-KT survival for combinations of donor quality and candidate condition. We studied deceased-donor KT recipients (N=120,818) and waitlisted candidates (N=376,272) between 2005 and 2016 using the Scientific Registry of Transplant Recipients. Donor quality and candidate condition were measured using Kidney Donor Profile Index (KDPI) and Estimate Post-Transplant Survival (EPTS)...
June 23, 2018: American Journal of Transplantation
Diefei Liang, Zijiao Song, Weiwen Liang, Yan Li, Shanying Liu
AIMS: Metformin is a biguanide derivative widely used for the treatment of type 2 diabetes mellitus. Recent evidence implicates that this anti-hyperglycemic drug exerts renal protective effects, yet the mechanisms remain poorly understood. MCP-1 has been recognized as a key mediator of renal fibrosis in chronic kidney diseases including diabetic nephropathy. This study aimed to investigate the effects of metformin on TGF-β1-induced MCP-1 expression and the underlying mechanisms in rat renal tubular epithelial cells...
June 22, 2018: Nephrology
Sakina Razack, Hemanth Kumar Kandikattu, M P Venuprasad, Narayanappa Amruta, Farhath Khanum, Krishna Chuttani, Anil Kumar Mishra
Nardostachys jatamansi has profound applications against pharmacological interventions and is categorized as a hypno-sedative drug according to Ayurveda. In the present study probable mechanism of anxiolytic action of Nardostachys jatamansi extract (NJE) was studied using behavioral anxiolytic tests (Elevated plus maze, Open field test, Light dark box test, and Vogel's conflict test) in mice. Mice were treated orally with NJE (250 mg/kg) for 3, 7 and 14 days or diazepam (1 mg/kg) followed by behavioral assessment and estimation of monoamine neurotransmitters, GABA, and antioxidant enzymes...
June 22, 2018: Metabolic Brain Disease
Josep Darbà, Meritxell Ascanio
BACKGROUND: Iron deficiency is a frequent complication of chronic kidney disease (CKD) that is associated with a decrease in the quality of life of patients and an increase in the risk of other clinical complications. Iron therapy represents one of the fundamentals of patients with CKD. Sucrosomial® oral iron allows Fisiogen Ferro Forte® to be used in all patients who are intolerant to treatment by the oral route of administration, or who present with malabsorption of conventional oral iron preparations...
June 22, 2018: Clinical Drug Investigation
Adrienne Lenhart, Salwa Hussain, Reena Salgia
BACKGROUND: Acute kidney injury in the setting of alcoholic liver disease portends a poor prognosis without liver transplant. AIMS: Using a tertiary care population, we aimed to evaluate the outcomes of renal replacement therapy in patients with alcoholic liver disease and acute kidney injury with < 6 months sobriety. METHODS: A retrospective review of hospitalized patients with alcoholic hepatitis/acute on chronic alcoholic cirrhosis and hepatorenal syndrome or acute tubular necrosis was performed...
June 22, 2018: Digestive Diseases and Sciences
Naoto Tominaga, Keisuke Kida, Takayuki Inomata, Naoki Sato, Tohru Izumi, Yoshihiro J Akashi, Yugo Shibagaki
BACKGROUND: Tolvaptan (TLV) is known to increase electrolyte-free water clearance. However, TLV actions on renal electrolytes including urine sodium (uNa) excretion and its consequences are less well understood. This subanalysis investigated the effect of add-on TLV compared to increased furosemide (FUR) on both electrolyte-free water and electrolyte clearance in patients with congestive heart failure (CHF) complicated by advanced chronic kidney disease (CKD). METHODS: The Kanagawa Aquaresis Investigators Trial of TLV on HF Patients with Renal Impairment (K-STAR) was a multicenter, open-labeled, randomized, and controlled prospective clinical study...
June 22, 2018: Clinical and Experimental Nephrology
Carla P Carlos, Analice A Silva, Cristiane D Gil, Sonia M Oliani
Galectin-1 protein (GAL-1) has important anti-inflammatory properties, but related pharmacologic approaches to effectively treat or prevent renal ischaemia and reperfusion injury are highly limited. Here, we investigated the effect of GAL-1 in a renal ischaemia-reperfusion injury rat model and an in vitro hypoxia-reoxygenation model with a proximal renal tubular epithelial cell line. In vivo, pretreatment with GAL-1 attenuated the renal parameters changed by ischaemia-reperfusion/hypoxia-reoxygenation, with recovery of renal function, protecting against influx of leukocytes, cell death and oxidative stress...
June 22, 2018: Scientific Reports
Saulius Vainauskas, Charlotte H Kirk, Laudine Petralia, Ellen P Guthrie, Elizabeth McLeod, Alicia Bielik, Alex Luebbers, Jeremy M Foster, Cornelis H Hokke, Pauline M Rudd, Xiaofeng Shi, Christopher H Taron
Exoglycosidases are often used for detailed characterization of glycan structures. Bovine kidney α-fucosidase is commonly used to determine the presence of core α1-6 fucose on N-glycans, an important modification of glycoproteins. Recently, several studies have reported that removal of core α1-6-linked fucose from N-glycans labeled with the reactive N-hydroxysuccinimide carbamate fluorescent labels 6-aminoquinolyl-N-hydroxysuccinimidylcarbamate (AQC) and RapiFluor-MS is severely impeded. We report here the cloning, expression and biochemical characterization of an α-fucosidase from Omnitrophica bacterium (termed fucosidase O)...
June 22, 2018: Scientific Reports
Simon Müller, Sonja Djudjaj, Janina Lange, Mihail Iacovescu, Margarete Goppelt-Struebe, Peter Boor
Acute kidney injury (AKI) is a common and potentially lethal complication in the hospitalized patients, with hypoxic injury being as a major cause. The loss of renal tubular epithelial cells (TEC), one of the AKI hallmarks, is potentially followed by tubular regeneration process orchestrated by the remaining uninjured TECs that undergo proliferation and migration. In this study, we used human primary TEC to investigate the initiation of tubular cell migration and associated cytoskeletal alterations in response to pharmacological HIF stabilization which resembles the pathophysiology of hypoxia...
June 22, 2018: Scientific Reports
Tom N Lea-Henry, Jane E Carland, Sophie L Stocker, Jacob Sevastos, Darren M Roberts
Kidney disease is an increasingly common comorbidity that alters the pharmacokinetics of many drugs. Prescribing to patients with kidney disease requires knowledge about the drug, the extent of the patient's altered physiology, and pharmacokinetic principles that influence the design of dosing regimens. There are multiple physiologic effects of impaired kidney function, and the extent to which they occur in an individual at any given time can be difficult to define. Although some guidelines are available for dosing in kidney disease, they may be on the basis of limited data or not widely applicable, and therefore, an understanding of pharmacokinetic principles and how to apply them is important to the practicing clinician...
June 22, 2018: Clinical Journal of the American Society of Nephrology: CJASN
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