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Prophylactic Cranial Irradiation

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https://www.readbyqxmd.com/read/28202905/risk-factors-for-brain-metastases-after-prophylactic-cranial-irradiation-in-small-cell-lung-cancer
#1
Haiyan Zeng, Peng Xie, Xue Meng, Shuanghu Yuan, Xindong Sun, Wanlong Li, Bingjie Fan, Xiaolin Li, Jinming Yu
Despite administration of prophylactic cranial irradiation (PCI), some small cell lung cancer (SCLC) patients still suffer from brain metastases (BM) with unknown risk factors. We conducted this study to identify patients with higher BM risk after PCI and improve their outcome. The characteristics and survival of all the SCLC patients underwent PCI in our institute from 2003 to 2014 were analyzed. Kaplan-Meier method was applied to estimate BM free survival (BMFS) and overall survival (OS). Cox regression analyses were performed to explore risk factors for BM...
February 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28182655/regional-analysis-of-volumes-and-reproducibilities-of-automatic-and-manual-hippocampal-segmentations
#2
Fabian Bartel, Hugo Vrenken, Fetsje Bijma, Frederik Barkhof, Marcel van Herk, Jan C de Munck
PURPOSE: Precise and reproducible hippocampus outlining is important to quantify hippocampal atrophy caused by neurodegenerative diseases and to spare the hippocampus in whole brain radiation therapy when performing prophylactic cranial irradiation or treating brain metastases. This study aimed to quantify systematic differences between methods by comparing regional volume and outline reproducibility of manual, FSL-FIRST and FreeSurfer hippocampus segmentations. MATERIALS AND METHODS: This study used a dataset from ADNI (Alzheimer's Disease Neuroimaging Initiative), including 20 healthy controls, 40 patients with mild cognitive impairment (MCI), and 20 patients with Alzheimer's disease (AD)...
2017: PloS One
https://www.readbyqxmd.com/read/28169879/long-term-results-of-the-risk-adapted-treatment-for-childhood-b-cell-acute-lymphoblastic-leukemia-report-from-the-japan-association-of-childhood-leukemia-study-all-97-trial
#3
Keizo Horibe, Keiko Yumura-Yagi, Tooru Kudoh, Shinichiro Nishimura, Megumi Oda, Makoto Yoshida, Yoshihiro Komada, Junichi Hara, Akio Tawa, Ikuya Usami, Akihiko Tanizawa, Koji Kato, Ryoji Kobayashi, Keitaro Matsuo, Hiroki Hori
PURPOSE: This study was conducted as the first clinical trial by Japan Association of Childhood Leukemia Study to improve the outcome of B-cell acute lymphoblastic leukemia and explore a less toxic reinduction block. PATIENTS AND METHODS: From 1997 to 2002, 563 patients with B-cell acute lymphoblastic leukemia aged 1 to 15 years were enrolled. The patients were assigned into 4 risk groups (standard, intermediate, high, or extremely high risk) and treated with regimens intensified according to the risk...
March 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/28154994/neutrophil-to-lymphocyte-ratio-predicts-outcome-in-limited-disease-small-cell-lung-cancer
#4
Lukas Käsmann, Louisa Bolm, Steven E Schild, Stefan Janssen, Dirk Rades
INTRODUCTION: Patients with limited disease small-cell lung cancer (SCLC) receive radiochemotherapy followed by prophylactic cranial irradiation. The prognosis of these patients remains poor with a median survival of 16-24 months. Systemic inflammation was suggested as an important prognostic factor for outcomes. This study investigated the impact of systemic inflammation measured with neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) at first diagnosis in patients with limited disease SCLC for outcomes...
February 2, 2017: Lung
https://www.readbyqxmd.com/read/28127669/neuron-specific-enolase-and-response-to-initial-therapy-are-important-prognostic-factors-in-patients-with-small-cell-lung-cancer
#5
M Zhou, Z Wang, Y Yao, H Zhou, M Liu, J Sun
PURPOSE: The prognostic factors for the survival of small cell lung cancer (SCLC) patients are still widely debated. The aim of this study was to identify the clinical features and prognostic factors in SCLC patients. METHODS: A retrospective study was conducted on SCLC patients who were treated in our hospital between July 2010 and July 2015. Comparison of overall survival (OS) was performed using the Kaplan-Meier method. Prognostic factors for OS were identified by multivariate Cox regression models...
January 26, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28123595/research-progress-in-the-treatment-of-small-cell-lung-cancer
#6
Yan-Fang Qiu, Zhi-Gang Liu, Wen-Juan Yang, Yu Zhao, Jiao Tang, Wei-Zhi Tang, Yi Jin, Fang Li, Rui Zhong, Hui Wang
Small cell lung cancer (SCLC) accounts for approximately 10-15% of all lung cancers. No significant improvement has been made for patients with SCLC in the past several decades. The main progresses were the thoracic radiation and prophylactic cranial irradiation (PCI) that improved the patient survival rate. For patients with limited disease and good performance status (PS), concurrent chemoradiotherapy (CCRT) followed by PCI should be considered. For extensive disease, the combination of etoposide and platinum-based chemotherapy remains the standard treatment and consolidative thoracic radiotherapy is beneficial for patients who have a significant respond to initial chemotherapy...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28115108/prophylactic-cranial-irradiation-or-no-prophylactic-cranial-irradiation-after-adjuvant-chemotherapy-in-resected-small-cell-lung-cancer
#7
EDITORIAL
Cecile Le Pechoux
No abstract text is available yet for this article.
February 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/28109544/cost-effectiveness-of-prophylactic-cranial-irradiation-with-hippocampal-avoidance-in-limited-stage-small-cell-lung-cancer
#8
Xuanlu M Qu, Mark V Mishra, Glenn S Bauman, Ben Slotman, Minesh Mehta, Vinai Gondi, Alexander V Louie
BACKGROUND AND PURPOSE: Prophylactic cranial irradiation (PCI) in limited stage small cell lung cancer (LS-SCLC) prevents brain metastases and improves survival, with the potential for neurocognitive toxicity. RTOG0933 demonstrated that hippocampal avoidance (HA) during whole brain radiotherapy preserves neurocognition. This study's objective was to evaluate the cost-effectiveness of HA-PCI in LS-SCLC through decision analysis. MATERIALS AND METHODS: A Markov model was developed to simulate the clinical course of LS-SCLC who received HA-PCI or conventional PCI (C-PCI)...
January 18, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28073578/prophylactic-cranial-irradiation-after-definitive-chemoradiotherapy-for-limited-stage-small-cell-lung-cancer-do-all-patients-benefit
#9
Ahsan S Farooqi, Emma B Holliday, Pamela K Allen, Xiong Wei, James D Cox, Ritsuko Komaki
PURPOSE: Prophylactic cranial irradiation (PCI) can improve overall survival (OS) and suppress brain metastases (BM) in patients with limited-stage small cell lung cancer (LS-SCLC) after complete response to primary therapy. However, PCI can be toxic. We sought to identify characteristics of patients who may not benefit from PCI. METHODS: We identified 658 patients who received chemoradiotherapy at MD Anderson in 1986-2012; 364 received PCI and 294 did not. Median follow-up time was 21...
January 7, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28065620/treatment-response-and-prophylactic-cranial-irradiation-are-prognostic-factors-in-a-real-life-limited-disease-small-cell-lung-cancer-patient-cohort-comprehensively-staged-with-cranial-magnetic-resonance-imaging
#10
Chukwuka Eze, Olarn Roengvoraphoj, Maximilian Niyazi, Guido Hildebrandt, Rainer Fietkau, Claus Belka, Farkhad Manapov
INTRODUCTION: Prophylactic cranial irradiation (PCI) has proven to decrease the incidence of brain metastases (BMs), with a modest improvement in survival. PATIENTS AND METHODS: The impact of PCI was evaluated in 184 patients treated with chemoradiotherapy. PCI was applied to patients with disease with partial and complete response only when cranial magnetic resonance imaging before and after primary treatment revealed no BMs. Correlation between PCI and overall survival (OS), BM-free survival (BMFS), and time to progression (TTP) was analyzed to describe survival within subgroups...
November 21, 2016: Clinical Lung Cancer
https://www.readbyqxmd.com/read/28027850/nine-year-experience-prophylactic-cranial-irradiation-in-extensive-disease-small-cell-lung%C3%A2-cancer
#11
Denise Bernhardt, Sebastian Adeberg, Farastuk Bozorgmehr, Nils Opfermann, Juliane Hoerner-Rieber, Michael C Repka, Jutta Kappes, Michael Thomas, Helge Bischoff, Felix Herth, Claus Peter Heußel, Jürgen Debus, Martin Steins, Stefan Rieken
BACKGROUND: In 2007, the European Organization for Research and Treatment of Cancer (EORTC) study (ClinicalTrials.gov identifier, NCT00016211) demonstrated a beneficial effect on overall survival (OS) with the use of prophylactic cranial irradiation (PCI) for extensive disease (ED) small-cell lung cancer (SCLC). Nevertheless, debate is ongoing regarding the role of PCI, because the patients in that trial did not undergo magnetic resonance imaging (MRI) of the brain before treatment. Also, a recent Japanese randomized trial showed a detrimental effect of PCI on OS in patients with negative pretreatment brain MRI findings...
December 2, 2016: Clinical Lung Cancer
https://www.readbyqxmd.com/read/28011047/multi-institutional-experience-of-stereotactic-ablative-radiation-therapy-for-stage-i-small-cell-lung-cancer
#12
Vivek Verma, Charles B Simone, Pamela K Allen, Sameer R Gajjar, Chirag Shah, Weining Zhen, Matthew M Harkenrider, Christopher L Hallemeier, Salma K Jabbour, Chance L Matthiesen, Steve E Braunstein, Percy Lee, Thomas J Dilling, Bryan G Allen, Elizabeth M Nichols, Albert Attia, Jing Zeng, Tithi Biswas, Peter Paximadis, Fen Wang, Joshua M Walker, John M Stahl, Megan E Daly, Roy H Decker, Russell K Hales, Henning Willers, Gregory M M Videtic, Minesh P Mehta, Steven H Lin
PURPOSE: For inoperable stage I (T1-T2N0) small cell lung cancer (SCLC), national guidelines recommend chemotherapy with or without conventionally fractionated radiation therapy. The present multi-institutional cohort study investigated the role of stereotactic ablative radiation therapy (SABR) for this population. METHODS AND MATERIALS: The clinical and treatment characteristics, toxicities, outcomes, and patterns of failure were assessed in patients with histologically confirmed stage T1-T2N0M0 SCLC...
February 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27981260/once-daily-high-dose-radiation-%C3%A2-60-gy-treatment-in-limited-stage-small-cell-lung-cancer
#13
Amir Zahra, Tangel Chang, Taher Abu Hejleh, Muhammad Furqan, Gerald H Clamon, Sudershan K Bhatia, John M Watkins, Sarah L Mott, Logan L Ahmann, Kellie L Bodeker, Douglas R Spitz, John M Buatti, Bryan G Allen
BACKGROUND: To investigate outcomes and prognostic factors in patients treated with once daily high-dose (≥60 Gy) radiation therapy (HDRT) and concurrent platinum-based chemotherapy in limited stage small cell lung cancer (LS-SCLC). While we await current phase III trials to determine optimal radiation dose fractionation schemes in LS-SCLC, we report our experience in LS-SCLC with once daily HDRT. We hypothesized that HDRT would achieve similar efficacy and tolerability as twice daily therapy...
November 2016: J Oncol Transl Res
https://www.readbyqxmd.com/read/27978874/-concurrent-chemoradiotherapy-with-original-chemotherapy-regimens-may-not-be-suitable-for-patients-who-failed-to-respond-to-induction-chemotherapy%C3%A2-in-limited-stage-small-cell-lung-cancer
#14
Daquan Wang, Liming Xu, Lujun Zhao, Wencheng Zhang, Qingsong Pang, Ningbo Liu, Xi Chen, Xiuli Chen, Zhiyong Yuan, Ping Wang
BACKGROUND: The group of small cell lung cancer (SCLC) are usually highly sensitive to chemotherapy, and less than 15% of them are resistant to drugs. We respectively evaluate the correlation of the sequence and timing of radiotherapy with progression-free survival (PFS) and overall survival (OS) in patients with limited-stage SCLC (LS-SCLC), and to figure out whether concurrent chemoradiotherapy is superior to sequent chemoradiotherapy. METHODS: Sixty-seven patients diagnosed with LS-SCLC from January 2009 to June 2014 failed to respond to induction chemotherapy...
December 20, 2016: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/27969462/mini01-15-prophylactic-cranial-irradiation-pci-for%C3%A2-limited-small-cell-lung-cancer-lsclc-an-iaslc-physician-survey-topic-radiation-oncology
#15
Laurie E Gaspar, Françoise Mornex, Feng-Ming Spring Kong, Fred Hirsch
No abstract text is available yet for this article.
November 2016: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/27907849/association-between-dehydroepiandrosterone-sulfate-and-attention-in-long-term-survivors-of-childhood-acute-lymphoblastic-leukemia-treated-with-only-chemotherapy
#16
Yin Ting Cheung, Wassim Chemaitilly, Daniel A Mulrooney, Tara M Brinkman, Wei Liu, Pia Banerjee, Deokumar Srivastava, Ching-Hon Pui, Leslie L Robison, Melissa M Hudson, Kevin R Krull
Long-term survivors of childhood acute lymphoblastic leukemia (ALL) are at risk for neurocognitive impairment, as well as compromised hypothalamic-pituitary-adrenal (HPA) function. Dehydroepiandrosterone-sulfate (DHEAS) is an adrenal androgen commonly used as a marker of HPA function. In the general population, a low level of DHEAS has been associated with poorer cognition. At ≥2years post-treatment, we examined the association of DHEAS with attention outcomes in 35 male and 34 female long-term survivors of childhood ALL (mean[standard deviation] age at evaluation 14...
February 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/27853828/prognostic-role-of-patient-gender-in-limited-disease-small-cell-lung-cancer-treated-with-chemoradiotherapy
#17
Olarn Roengvoraphoj, Chukwuka Eze, Maximilian Niyazi, Minglun Li, Guido Hildebrandt, Rainer Fietkau, Claus Belka, Farkhad Manapov
BACKGROUND: Previous studies have demonstrated that female gender could be a prognostic factor in limited-disease (LD) small-cell lung cancer (SCLC), but the correlation between patient gender and survival parameters remains unclear. PATIENTS AND METHODS: Data from 179 LD SCLC patients treated with definitive chemoradiotherapy (CRT) were reviewed. Influence of patient gender on time to progression (TTP), local control (LC), brain metastasis-free (BMFS), distant metastasis-free (DMFS) and overall survival (OS) was analysed...
February 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/27794411/outcome-in-patients-with-small-cell-lung-cancer-re-irradiated-for-brain-metastases-after-prior-prophylactic-cranial-irradiation
#18
Denise Bernhardt, Farastuk Bozorgmehr, Sebastian Adeberg, Nils Opfermann, Damian von Eiff, Juliane Rieber, Jutta Kappes, Robert Foerster, Laila König, Michael Thomas, Jürgen Debus, Martin Steins, Stefan Rieken
OBJECTIVES: Patients with brain metastases from small-cell lung cancer (SCLC) who underwent prior prophylactic cranial irradiation (PCI) are often treated with a second course of whole brain radiation therapy (Re-WBRT) or stereotactic radiosurgery (SRS) for purposes of palliation in symptomatic patients, hope for increased life expectancy or even as an alternative to untolerated steroids. Up to date there is only limited data available regarding the effect of this treatment. This study examines outcomes in patients in a single institution who underwent cerebral re-irradiation after prior PCI...
November 2016: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/27790279/the-younger-patients-have-more-better-prognosis-in-limited-disease-small-cell-lung-cancer
#19
Hye-Jin Kim, Chang-Min Choi, Seul-Gi Kim
BACKGROUND: Factors associated with the prognosis of patients with small cell lung cancer (SCLC) is relatively unknown, than of those with non-small cell lung cancer. This study was undertaken to identify the prognostic factors of SCLC. METHODS: The medical records of 333 patients diagnosed with SCLC at tertiary hospital from January 1, 2008, to December 31, 2012 were retrospectively reviewed. Patients were categorized by age (≤65 years vs. >65 years) and by extent of disease (limited disease [LD] vs extensive disease [ED])...
October 2016: Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/27785518/analysis-of-risk-factors-for-pulmonary-complications-in-patients-with-limited-stage-small-cell-lung-cancer-a-single-centre-retrospective-study
#20
Beata Sas-Korczyńska, Elżbieta Łuczyńska, Wojciech Kamzol, Andrzej Sokołowski
INTRODUCTION: The most effective therapy in patients with limited-stage small cell lung cancer (LS SCLC) seems to be chemotherapy (using platinum-based regimens) and thoracic radiotherapy (TRT), which is followed by prophylactic cranial irradiation. MATERIALS AND METHODS: The analysed group comprised 217 patients who received combined treatment for LS SCLC, i.e. chemotherapy (according to cisplatin and etoposide schedule) and TRT (concurrent in 101 and sequential in 116 patients)...
February 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
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