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https://www.readbyqxmd.com/read/28202206/retrospective-chart-analysis-of-concussion-discharge-instructions-in-the-emergency-department
#1
Allison D Lane, Matthew R Berkman, David Verbunker, Taylor Shekell, Michael Bouska, Lauren Barnett, Allie Keogh, Tomas Nuno, Uwe Stolz, Anna L Waterbrook
BACKGROUND: Recognition and diagnosis of concussion is increasing, but current research shows these patients are discharged from the emergency department (ED) with a wide variability of recommendations and instructions. OBJECTIVE: To assess the adequacy of documentation of discharge instructions given to patients discharged from the ED with concussions. METHODS: This was a quality-improvement study conducted at a University-based Level I trauma center...
February 12, 2017: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28193147/print-on-demand
#2
Sarah Webb
Advances in 3-D printing and biomaterials are helping to shape the field of regenerative medicine. Sarah Webb examines the latest developments.
February 1, 2017: BioTechniques
https://www.readbyqxmd.com/read/28185142/print-me-an-organ-ethical-and-regulatory-issues-emerging-from-3d-bioprinting-in-medicine
#3
Frederic Gilbert, Cathal D O'Connell, Tajanka Mladenovska, Susan Dodds
Recent developments of three-dimensional printing of biomaterials (3D bioprinting) in medicine have been portrayed as demonstrating the potential to transform some medical treatments, including providing new responses to organ damage or organ failure. However, beyond the hype and before 3D bioprinted organs are ready to be transplanted into humans, several important ethical concerns and regulatory questions need to be addressed. This article starts by raising general ethical concerns associated with the use of bioprinting in medicine, then it focuses on more particular ethical issues related to experimental testing on humans, and the lack of current international regulatory directives to guide these experiments...
February 9, 2017: Science and Engineering Ethics
https://www.readbyqxmd.com/read/28182019/a-modular-approach-to-the-design-fabrication-and-characterization-of-muscle-powered-biological-machines
#4
Ritu Raman, Caroline Cvetkovic, Rashid Bashir
Biological machines consisting of cells and biomaterials have the potential to dynamically sense, process, respond, and adapt to environmental signals in real time. As a first step toward the realization of such machines, which will require biological actuators that can generate force and perform mechanical work, we have developed a method of manufacturing modular skeletal muscle actuators that can generate up to 1.7 mN (3.2 kPa) of passive tension force and 300 μN (0.56 kPa) of active tension force in response to external stimulation...
March 2017: Nature Protocols
https://www.readbyqxmd.com/read/28151046/a-3-d-puzzle-approach-to-building-protein-dna-structures
#5
Deborah M Hinton
Despite recent advances in structural analysis, it is still challenging to obtain a high resolution structure for a complex of RNA polymerase, transcriptional factors, and DNA. However, using biochemical constraints, 3-D printed models of available structures, and computer modeling, one can build biologically relevant models of such supramolecular complexes.
February 2, 2017: Transcription
https://www.readbyqxmd.com/read/28142354/the-use-of-three-dimensional-printing-technology-in-orthopaedic-surgery
#6
Tak Man Wong, Jimmy Jin, Tak Wing Lau, Christian Fang, Chun Hoi Yan, Kelvin Yeung, Michael To, Frankie Leung
Three-dimensional (3-D) printing or additive manufacturing, an advanced technology that 3-D physical models are created, has been wildly applied in medical industries, including cardiothoracic surgery, cranio-maxillo-facial surgery and orthopaedic surgery. The physical models made by 3-D printing technology give surgeons a realistic impression of complex structures, allowing surgical planning and simulation before operations. In orthopaedic surgery, this technique is mainly applied in surgical planning especially revision and reconstructive surgeries, making patient-specific instruments or implants, and bone tissue engineering...
January 2017: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/28128293/improved-prediction-of-severe-thunderstorms-over-the-indian-monsoon-region-using-high-resolution-soil-moisture-and-temperature-initialization
#7
K K Osuri, R Nadimpalli, U C Mohanty, F Chen, M Rajeevan, D Niyogi
The hypothesis that realistic land conditions such as soil moisture/soil temperature (SM/ST) can significantly improve the modeling of mesoscale deep convection is tested over the Indian monsoon region (IMR). A high resolution (3 km foot print) SM/ST dataset prepared from a land data assimilation system, as part of a national monsoon mission project, showed close agreement with observations. Experiments are conducted with (LDAS) and without (CNTL) initialization of SM/ST dataset. Results highlight the significance of realistic land surface conditions on numerical prediction of initiation, movement and timing of severe thunderstorms as compared to that currently being initialized by climatological fields in CNTL run...
January 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28114439/conflict-of-interest-in-seminal-hepatitis-c-virus-and-cholesterol-management-guidelines
#8
Akilah A Jefferson, Steven D Pearson
Importance: Little is known regarding whether Institute of Medicine (IOM) standards for managing conflicts of interest (COI) have been met in the development of recent important clinical guidelines. Objective: To evaluate adherence to the IOM standards for limits on commercial COI, guideline development, and evaluation of evidence by the 2013 American College of Cardiology and American Heart Association cholesterol management guideline and the 2014 American Association for the Study of Liver Diseases and Infectious Diseases Society of America hepatitis C virus management guideline...
January 17, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28113194/development-of-novel-3-d-printed-scaffolds-with-core-shell-nanoparticles-for-nerve-regeneration
#9
Se-Jun Lee, Wei Zhu, Lanier Heyburn, Margaret Nowicki, Brent Harris, Lijie Grace Zhang
A traumatic injury of peripheral nerves is serious clinical problem that may lead to major loss of nerve function, affecting quality of patient's life. Currently, nerve autograft is widely used to reconstruct the nerve gap. However, such surgical procedure suffers from many disadvantages including donor site morbidity and limited availability. In order to address these issues, neural tissue engineering has focused on the development of synthetic nerve scaffolds to support bridging a larger gap and improving nerve generation...
February 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28105891/friction-of-sodium-alginate-hydrogel-scaffold-fabricated-by-3-d-printing
#10
Qian Yang, Jian Li, Heng Xu, Shijun Long, Xuefeng Li
A rapid prototyping technology, formed by three-dimensional (3-D) printing and then crosslinked by spraying Ca(2+) solution, is developed to fabricate a sodium alginate (SA) hydrogel scaffold. The porosity, swelling ratio, and compression modulus of the scaffold are investigated. A friction mechanism is developed by studying the reproducible friction behavior. Our results show that the scaffold can have 3-D structure with a porosity of 52%. The degree of swelling of the SA hydrogel scaffold is 8.5, which is nearly the same as bulk SA hydrogel...
January 20, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28103068/suicide-deaths-with-opioid-poisoning-in-the-united-states-1999-2014
#11
Jennifer Brennan Braden, Mark J Edlund, Mark D Sullivan
OBJECTIVES: To describe trends in suicides with opioid poisoning noted as a contributing cause of death. METHODS: Using National Vital Statistics data (1999-2014), we calculated age-adjusted rates of suicide with opioid poisoning (International Classification of Diseases, Tenth Revision codes T40.0-T40.4) per 100 000 population per year and annual percentage change (APC) in rates. We used Joinpoint regression to examine trends in suicide rates and proportion of suicides involving opioids...
March 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28094997/combined-inkjet-printing-and-infra-red-sintering-of-silver-nanoparticles-using-a-swathe-by-swathe-and-layer-by-layer-approach-for-3-dimensional-structures
#12
Jayasheelan Vaithilingam, Marco Simonelli, Ehab Saleh, Nicola Senin, Ricky D Wildman, Richard J M Hague, Richard K Leach, Christopher J Tuck
Despite the advancement of additive manufacturing/3-dimensional (3D) printing, single-step fabrication of multifunctional parts using AM is limited. With the view of enabling multifunctional AM (MFAM), in this study, sintering of metal nanoparticles was performed to obtain conductivity for continuous line inkjet printing of electronics. This was achieved using a bespoke three dimensional (3D) inkjet-printing machine, JETx®, capable of printing a range of materials and utilizing different post processing procedures to print multi-layered 3D structures in a single manufacturing step...
January 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28079120/in-situ-imaging-of-microstructure-formation-in-electronic-interconnections
#13
M A A Mohd Salleh, C M Gourlay, J W Xian, S A Belyakov, H Yasuda, S D McDonald, K Nogita
The development of microstructure during melting, reactive wetting and solidification of solder pastes on Cu-plated printed circuit boards has been studied by synchrotron radiography. Using Sn-3.0Ag-0.5Cu/Cu and Sn-0.7Cu/Cu as examples, we show that the interfacial Cu6Sn5 layer is present within 0.05 s of wetting, and explore the kinetics of flux void formation at the interface between the liquid and the Cu6Sn5 layer. Quantification of the nucleation locations and anisotropic growth kinetics of primary Cu6Sn5 crystals reveals a competition between the nucleation of Cu6Sn5 in the liquid versus growth of Cu6Sn5 from the existing Cu6Sn5 layer...
January 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28072573/design-and-application-of-a-structured-phantom-for-detection-performance-comparison-between-breast-tomosynthesis-and-digital-mammography
#14
L Cockmartin, N W Marshall, G Zhang, K Lemmens, E Shaheen, C Van Ongeval, E Fredenberg, D R Dance, E Salvagnini, K Michielsen, H Bosmans
This paper introduces and applies a structured phantom with inserted target objects for the comparison of detection performance of digital breast tomosynthesis (DBT) against 2D full field digital mammography (FFDM). The phantom consists of a 48 mm thick breast-shaped polymethyl methacrylate (PMMA) container filled with water and PMMA spheres of different diameters. Three-dimensionally (3D) printed spiculated masses (diameter range: 3.8-9.7 mm) and non-spiculated masses (1.6-6.2 mm) along with microcalcifications (90-250 µm) were inserted as targets...
January 10, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28059780/separation-control-over-a-grooved-surface-inspired-by-dolphin-skin
#15
Amy W Lang, Emily M Jones, Farhana Afroz
Over many decades the biological surfaces of aquatic swimmers have been studied for their potential as drag reducing surfaces. The hydrodynamic benefit of riblets, or grooves embedded parallel to the flow which appear on surfaces such as shark skin, have been well documented. However the skin of dolphins is embedded with sinusoidal grooves that run perpendicular or transverse to the flow over their bodies. It is theorized that the transverse grooves present on dolphin skin trap vortices between them, creating a partial slip condition over the surface and inducing turbulence augmentation in the boundary layer, thus acting as a potential mechanism to reduce flow separation and thus pressure drag...
February 10, 2017: Bioinspiration & Biomimetics
https://www.readbyqxmd.com/read/28056140/benefits-and-limitations-of-entry-level-3-dimensional-printing-of-maxillofacial-skeletal-models
#16
Alex T Legocki, Andrew Duffy-Peter, Andrew R Scott
Importance: A protocol for creating exceptionally low-cost 3-dimensional (3-D) maxillofacial skeletal models does not require proficiency with computer software or intensive labor. Small and less affluent centers can produce models with little loss in accuracy and clinical utility. Objectives: To highlight the feasibility and methods of introducing in-house, entry-level additive manufacturing (3-D printing) technology to otolaryngologic craniofacial reconstruction and to describe its clinical applications and limitations, including a comparison with available vendor models...
January 5, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28049583/purification-of-semiconducting-single-walled-carbon-nanotubes-by-spiral-counter-current-chromatography
#17
Martha Knight, Rodrigo Lazo-Portugal, Saeyoung Nate Ahn, Steingrimur Stefansson
Over the last decade man-made carbon nanostructures have shown great promise in electronic applications, but they are produced as very heterogeneous mixtures with different properties so the achievement of a significant commercial application has been elusive. The dimensions of single-wall carbon nanotubes are generally a nanometer wide, up to hundreds of microns long and the carbon nanotubes have anisotropic structures. They are processed to have shorter lengths but they need to be sorted by diameter and chirality...
February 3, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28047923/tu-h-brc-08-use-and-validation-of-flexible-3d-printed-tissue-compensators-for-post-mastectomy-radiation-therapy
#18
D Craft, W Woodward, J Kanke, S Kry, M Salehpour, R Howell
PURPOSE: Patient-specific tissue equivalent compensators can be used for post-mastectomy radiation therapy (PMRT) to achieve homogenous dose distributions with single-field treatments. However, current fabrication methods are time consuming and expensive. 3D-printing technology could overcome these limitations. The purposes of this study were to [1] evaluate materials for 3D-printed compensators [2] design and print a compensator to achieve a uniform thickness to a clinical target volume (CTV), and [3] demonstrate that a single-field electron compensator plan is a clinically feasible treatment option for PMRT...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046821/su-g-201-07-dosimetric-verification-of-a-3d-printed-hdr-skin-brachytherapy-applicator
#19
K Rasmussen, A Baumgarten, D Stanley, C Pelletier, M Corbett, J Jung, Y Feng, Z Huang, A Ju, T Eng, N Kirby, A Gutierrez, S Stathakis, N Papanikolaou
PURPOSE: The use of radiation as a treatment modality for skin cancer has increased significantly over the last decade with standardized applicators. Utilizing 3D printing, the ability to make applicators specifically designed for each patient's anatomy has become economically feasible. With this in mind it was the aim of this study to determine the dosimetric accuracy of a 3-D printed HDR brachytherapy applicator for the skin. METHODS: A CT reference image was used to generate a custom applicator based on an anthropomorphic head and neck phantom...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046350/we-de-bra-04-a-cost-effective-pixelated-epid-scintillator-for-enhanced-contrast-and-dqe
#20
J Rottmann, M Myronakis, Y Hu, D Shedlock, A Wang, D Humber, D Morf, R Fueglistaller, J Star-Lack, R Berbeco
PURPOSE: Beams-eye-view imaging applications such as real-time soft-tissue motion estimation and MV-CBCT are hindered by the inherently low image contrast of electronic portal imaging devices (EPID) currently in clinical use. We investigate a cost effective scintillating glass that provides substantially increased detective quantum efficiency (DQE) and contrast to noise ratio (CNR). METHODS: A pixelated scintillator prototype was built from LKH-5 glass. The array is 12mm thick; 42...
June 2016: Medical Physics
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