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Healthcare associated infections

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https://www.readbyqxmd.com/read/28936375/hand-hygiene-practices-among-indian-medical-undergraduates-a-questionnaire-based-survey
#1
Pranav D Modi, Pooja Kumar, Rajavi Solanki, Janhavi Modi, Srinath Chandramani, Niharika Gill
Background and objectives To prevent the spread of infections in all healthcare settings, hand hygiene must be routinely practiced. Appropriate hand hygiene techniques can go a long way in reducing nosocomial infections, cross-transmission of microorganisms and the risk of occupational exposure to infectious diseases. World Health Organisation (WHO) has taken an incredible approach called "My Five Moments for Hand Hygiene" which defines the key moments when health-care workers should perform hand hygiene. We thus carried out a survey to assess knowledge of hand hygiene practices among undergraduate medical students...
July 12, 2017: Curēus
https://www.readbyqxmd.com/read/28935832/an-electronic-trigger-based-on-care-escalation-to-identify-preventable-adverse-events-in-hospitalised-patients
#2
Viraj Bhise, Dean F Sittig, Viralkumar Vaghani, Li Wei, Jessica Baldwin, Hardeep Singh
BACKGROUND: Methods to identify preventable adverse events typically have low yield and efficiency. We refined the methods of Institute of Healthcare Improvement's Global Trigger Tool (GTT) application and leveraged electronic health record (EHR) data to improve detection of preventable adverse events, including diagnostic errors. METHODS: We queried the EHR data repository of a large health system to identify an 'index hospitalization' associated with care escalation (defined as transfer to the intensive care unit (ICU) or initiation of rapid response team (RRT) within 15 days of admission) between March 2010 and August 2015...
September 21, 2017: BMJ Quality & Safety
https://www.readbyqxmd.com/read/28933204/healthcare-utilization-and-direct-costs-of-non-infectious-comorbidities-in-hiv-infected-patients-in-the-usa
#3
Joel Gallant, Priscilla Hsue, David Budd, Nicole Meyer
OBJECTIVE: To estimate the incremental healthcare utilization and costs associated with common non-infectious comorbid conditions among commercially and Medicaid-insured HIV-infected patients in the US. METHODS: US administrative claims were used to select adult HIV patients with chronic kidney disease (CKD), cardiovascular disease (CVD) events, or fracture/osteoporosis, three common comorbidities that have been associated with HIV and HIV treatment, between 01/012004 and 06/30/2013...
September 21, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28932346/insights-from-the-draft-genome-into-the-pathogenicity-of-a-clinical-isolate-of-elizabethkingia-meningoseptica-em3
#4
Shicheng Chen, Marty Soehnlen, Frances P Downes, Edward D Walker
Elizabethkingia meningoseptica is an emerging, healthcare-associated pathogen causing a high mortality rate in immunocompromised patients. We report the draft genome sequence of E. meningoseptica Em3, isolated from sputum from a patient with multiple underlying diseases. The genome has a length of 4,037,922 bp, a GC-content 36.4%, and 3673 predicted protein-coding sequences. Average nucleotide identity analysis (>95%) assigned the bacterium to the species E. meningoseptica. Genome analysis showed presence of the curli formation and assembly operon and a gene encoding hemagglutinins, indicating ability to form biofilm...
2017: Standards in Genomic Sciences
https://www.readbyqxmd.com/read/28930487/emerging-roles-of-inflammasomes-in-acute-pneumonia
#5
Sangeetha Ravi Kumar, Sagar Paudel, Laxman Ghimire, Scott Bergeron, Shanshan Cai, Rachel L Zemans, Gregory P Downey, Samithamby Jeyaseelan
Pneumonia is responsible for a substantial burden on healthcare worldwide and the single largest cause for death of infants globally. Pneumonia is caused by a variety of pathogenic microorganisms including bacteria, viruses and fungi. The lung has developed complex innate immune mechanisms to combat these infections while minimizing tissue damage. One essential mechanism that drives the initial innate immune response is sensing a broad spectrum of stimuli in the cytosol by inflammasomes. Inflammasomes are composed of NLR and non-NLR proteins, and activate caspase-1 that results in proinflammatory cytokine activation...
September 20, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28930010/disease-burden-of-clostridium-difficile-infections-in-adults-hong-kong-china-2006-2014
#6
Jeffery Ho, Rudin Z W Dai, Thomas N Y Kwong, Xiansong Wang, Lin Zhang, Margaret Ip, Raphael Chan, Peter M K Hawkey, Kelvin L Y Lam, Martin C S Wong, Gary Tse, Matthew T V Chan, Francis K L Chan, Jun Yu, Siew C Ng, Nelson Lee, Justin C Y Wu, Joseph J Y Sung, William K K Wu, Sunny H Wong
Cross-sectional studies suggest an increasing trend in incidence and relatively low recurrence rates of Clostridium difficile infections in Asia than in Europe and North America. The temporal trend of C. difficile infection in Asia is not completely understood. We conducted a territory-wide population-based observational study to investigate the burden and clinical outcomes in Hong Kong, China, over a 9-year period. A total of 15,753 cases were identified, including 14,402 (91.4%) healthcare-associated cases and 817 (5...
October 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28924472/the-effect-of-antibiotic-use-on-prevalence-of-nosocomial-vancomycin-resistant-enterococci-an-ecologic-study
#7
Cornelius Remschmidt, Michael Behnke, Axel Kola, Luis A Peña Diaz, Anna M Rohde, Petra Gastmeier, Frank Schwab
BACKGROUND: Vancomycin-resistant enterococci (VRE) are among the most common antimicrobial-resistant pathogens causing nosocomial infections. Although antibiotic use has been identified as a risk factor for VRE, it remains unclear which antimicrobial agents particularly facilitate VRE selection. Here, we assessed whether use of specific antimicrobial agents is independently associated with healthcare-associated (HA) VRE rates in a university hospital setting in Berlin, Germany. METHODS: We conducted the study between January 2014 and December 2015 at the Charité-university hospital of Berlin, Germany...
2017: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/28923034/an-implementation-science-protocol-of-the-women-s-health-coop-in-healthcare-settings-in-cape-town-south-africa-a-stepped-wedge-design
#8
Wendee M Wechsberg, Jacqueline W Ndirangu, Ilene S Speizer, William A Zule, Winnifred Gumula, Courtney Peasant, Felicia A Browne, Laura Dunlap
BACKGROUND: HIV persists as a public health emergency in South Africa, especially among women of childbearing age. In response to the HIV epidemic, the Joint United Nations Programme on HIV/AIDS has put forth the 90-90-90 global goals to achieve an AIDS-free generation by 2020. This goal aspires to have 90% of people living with HIV diagnosed; 90% of those who test positive on sustained antiretroviral therapy (ART); and 90% of those on ART be virally suppressed. Ensuring access to ART is an important first step in reducing HIV incidence, especially among vulnerable populations such as women who use substances and bear the burden of HIV in South Africa...
September 18, 2017: BMC Women's Health
https://www.readbyqxmd.com/read/28921804/early-blood-stream-infection-following-allogeneic-hematopoietic-stem-cell-transplantation-is-a-risk-factor-for-acute-grade-iii-iv-gvhd-in-children-and-adolescents
#9
Hirozumi Sano, Joseph A Hilinski, Muna Qayed, Kristy Applegate, Joanna G Newton, Benjamin Watkins, Kuang-Yueh Chiang, John Horan
BACKGROUND: Graft-versus-host disease (GVHD) remains a major cause of mortality and morbidity in allogeneic hematopoietic stem cell transplantation (HSCT). In adults, early blood stream infection (BSI) and acute GVHD (AGVHD) have been reported to be related. The impact of BSI on risk for AGVHD, however, has not been assessed in pediatric patients. PROCEDURE: We conducted a retrospective analysis to test the hypothesis that early BSI (before day +30) predisposes allogeneic pediatric transplant patients to severe AGVHD...
September 17, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28918461/ethnic-differences-in-maternal-near-miss
#10
Karayna Gil Fernandes, Renato Teixeira Souza, Maria Carmo Leal, Erly C Moura, Leonor M Santos, Jose Guilherme Cecatti
PURPOSE: To evaluate the association between ethnic differences and the occurrence of maternal near miss (MNM) in the Amazon and Northeast regions of Brazil. METHODS: This is a secondary analysis of a national cross-sectional study focused on the assessment of care to pregnancy, childbirth, and infants under 1 year of age. Ethnicity was classified as white, black or indigenous. Ethnic distribution by state and region, the proportion of severe maternal complications and related procedures, and the prevalence of MNM and its criteria were calculated for the ethnic groups...
September 16, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28917436/comparison-of-the-loop-technique-with-incision-and-drainage-for-soft-tissue-abscesses-a-systematic-review-and-meta-analysis
#11
REVIEW
Michael Gottlieb, Gary D Peksa
INTRODUCTION: Skin and soft tissue infections are a common presentation to the emergency department. Traditional management of abscesses involves a linear incision through the center of the abscess with packing placed. The loop drainage technique (LDT) is an alternate approach that may reduce pain and scarring, as well as decrease the number of follow up visits needed. This systematic review and meta-analysis aimed to compare the efficacy of the LDT with conventional incision and drainage (CID) in the treatment of soft tissue abscesses...
September 10, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28916877/bile-duct-injury-and-morbidity-following-cholecystectomy-a-need-for-improvement
#12
Meredith Barrett, Horacio J Asbun, Hung-Lung Chien, L Michael Brunt, Dana A Telem
BACKGROUND: Bile duct injury (BDI) remains the most dreaded complication following cholecystectomy with serious repercussions for the surgeon, patient and entire healthcare system. In the absence of registries, the true incidence of BDI in the United States remains unknown. We aim to identify the incidence of BDI requiring operative intervention and overall complications after cholecystectomy. METHODS: Utilizing the Truven Marketscan(®) research database, 554,806 patients who underwent cholecystectomy in calendar years 2011-2014 were identified using ICD-9 procedure and diagnosis codes...
September 15, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28914275/national-trends-2007-2013-of-clostridium-difficile-infection-in-patients-with-septic-shock-impact-on-outcome
#13
Kshitij Chatterjee, Abhinav Goyal, Aditya Chada, Krishna Siva Kakkera, Howard L Corwin
BACKGROUND: Clostridium difficile is the most common infectious cause of healthcare-associated diarrhea and is associated with worse outcomes and higher cost. Patients with septic shock (SS) are at increased risk of acquiring C. difficile infections (CDIs) during hospitalization, but little data are available on CDI complicating SS. OBJECTIVE: Prevalence of CDI in SS between 2007-2013 and impact of CDI on outcomes in SS. METHODS: Outcomes were prevalence of CDI in SS, effect on mortality, length of stay (LOS), and 30-day readmission...
September 2017: Journal of Hospital Medicine: An Official Publication of the Society of Hospital Medicine
https://www.readbyqxmd.com/read/28914209/knee-ligament-injury-and-the-clinical-application-of-tissue-engineering-techniques-a-systematic-review
#14
Thomas Riley, Reza Mafi, Pouya Mafi, Wasim Khan
Background The incidence of knee ligament injury is increasing and represents a significant cost to healthcare providers. Current interventions include tissue grafts, suture repair and non-surgical management. These techniques have demonstrated good patient outcomes but have been associated graft rejection, infection, long term immobilization and reduced joint function. The limitations of traditional management strategies have prompted research into tissue engineering of knee ligaments. Objective This paper aims to evaluate whether tissue engineering of knee ligaments offers a viable alternative in the clinical management of knee ligament injuries...
September 15, 2017: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28914066/-herpes-simplex-virus-infection-an-overview-of-the-problem-pharmacologic-therapy-and-dietary-measures
#15
Sherif T S Hassan, Miroslava Šudomová, Radka Masarčíková
Treatment of infectious diseases remains one of the principal research target for many researchers and healthcare providers worldwide. Herpes simplex virus 1 (HSV-1) and herpes simplex virus 2 (HSV-2) are common human pathogens with an estimated 60-95% of the adult population infected by at least one of them. The worldwide disease burden of HSV is substantial, and acyclovir and related nucleoside analogues (viral DNA polymerase inhibitors) as therapies have led to significantly increased treatment efficacy of HSV infections...
2017: Ceská a Slovenská Farmacie
https://www.readbyqxmd.com/read/28911645/antibiofilm-activity-of-cashew-juice-pulp-against-staphylococcus-aureus-high-performance-liquid-chromatography-diode-array-detection-and-gas-chromatography-mass-spectrometry-analyses-and-interference-on-antimicrobial-drugs
#16
Marcus V Dias-Souza, Renan M Dos Santos, Ezequias P de Siqueira, Pedro H Ferreira-Marçal
The epidemiology of Staphylococcus aureus infections has evolved in recent years, as this species is a major Gram-positive pathogen associated with healthcare services. The antimicrobial resistance of this species raises an urgent need for new treatment strategies. Fruits play important nutritional and economic roles in society, but their biological and pharmacological features are poorly explored when compared to nonedible parts of plants such as barks and leaves. In this study, we show that the cashew apple juice [cashew juice pulp (CJP)] extract is active against the planktonic cells of S...
July 2017: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/28911130/on-the-ferries-the-unmet-health-care-needs-of-transiting-refugees-in-greece
#17
Clare K Shortall, Rosanna Glazik, Alvin Sornum, Ceri Pritchard
Background: In 2015, over 850 000 refugees, asylum seekers and migrants arrived in Greece. In response to an overwhelming need for access to healthcare for them, Doctors of the World established the Refugee Ferry Project, which comprised of a clinic providing primary health care, and integrated mental health and psychosocial support on board a commercial ferry. Methods: Of the 1405 service users, 87.5% (1229/1405) originated from Syria, Afghanistan and Iraq. The majority were women 801/1405 (57%) and children 511/1405 (36%), including 50 pregnant women and 19 unaccompanied minors...
September 1, 2017: International Health
https://www.readbyqxmd.com/read/28906399/characteristics-of-infection-and-its-impact-on-short-term-outcome-in-patients-with-acute-on-chronic-liver-failure
#18
Junjun Cai, Mengchen Zhang, Tao Han, Hui-Qing Jiang
Bacterial infections are an important cause of mortality in liver failure. However, the type of infection, predictors of infection, and their impact on outcomes in patients with acute-on-chronic liver failure (ACLF) are limited.A total of 389 patients with ACLF were admitted in this retrospective, corhort study. Once admitted, clinical data including first infection site, type (community-acquired, healthcare-associated, or nosocomial), and second infection occurrence during hospitalization were collected. The outcome was mortality within 90 days...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28906133/an-online-calculator-to-estimate-the-impact-of-changes-in-breastfeeding-rates-on-population-health-and-costs
#19
Alison M Stuebe, Briana J Jegier, Eleanor Bimla Schwarz, Brittany D Green, Arnold G Reinhold, Tarah T Colaizy, Debra L Bogen, Andrew J Schaefer, Jamus T Jegier, Noah S Green, Melissa C Bartick
OBJECTIVE: We sought to determine the impact of changes in breastfeeding rates on population health. MATERIALS AND METHODS: We used a Monte Carlo simulation model to estimate the population-level changes in disease burden associated with marginal changes in rates of any breastfeeding at each month from birth to 12 months of life, and in rates of exclusive breastfeeding from birth to 6 months of life. We used these marginal estimates to construct an interactive online calculator (available at www...
September 14, 2017: Breastfeeding Medicine: the Official Journal of the Academy of Breastfeeding Medicine
https://www.readbyqxmd.com/read/28905331/antibiotic-distribution-into-cerebrospinal-fluid-can-dosing-safely-account-for-drug-and-disease-factors-in-the-treatment-of-ventriculostomy-associated-infections
#20
Nilesh Kumta, Jason A Roberts, Jeffrey Lipman, Menino Osbert Cotta
Ventriculostomy-associated infections, or ventriculitis, in critically ill patients are associated with considerable morbidity. Efficacious antibiotic dosing for the treatment of these infections may be complicated by altered antibiotic concentrations in the cerebrospinal fluid due to variable meningeal inflammation and antibiotic properties. Therefore, doses used to treat infections with a higher degree of meningeal inflammation (such as meningitis) may often fail to achieve equivalent exposures in patients with ventriculostomy-associated infections such as ventriculitis...
September 13, 2017: Clinical Pharmacokinetics
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